PIK3AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact6.32412259
2modulation by symbiont of host immune response (GO:0052553)6.32412259
3positive regulation by symbiont of host defense response (GO:0052509)6.32412259
4modulation by symbiont of host defense response (GO:0052031)6.32412259
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.32412259
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.32412259
7regulation of interferon-beta biosynthetic process (GO:0045357)5.36183104
8macrophage activation involved in immune response (GO:0002281)4.78363889
9positive regulation of interferon-alpha production (GO:0032727)4.64081061
10positive regulation of gamma-delta T cell activation (GO:0046645)4.58157548
11regulation of interferon-alpha production (GO:0032647)4.47244004
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39067867
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33906111
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.33906111
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.33687700
16antigen processing and presentation of endogenous antigen (GO:0019883)4.26698665
17response to host immune response (GO:0052572)4.13104388
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.13104388
19detection of other organism (GO:0098543)4.11811175
20positive regulation of B cell differentiation (GO:0045579)4.02654557
21immunoglobulin mediated immune response (GO:0016064)4.01821980
22neutrophil activation involved in immune response (GO:0002283)3.96652480
23response to peptidoglycan (GO:0032494)3.95814866
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83086410
25response to host (GO:0075136)3.83086410
26response to host defenses (GO:0052200)3.83086410
27detection of bacterium (GO:0016045)3.81153314
28regulation of B cell receptor signaling pathway (GO:0050855)3.80700798
29detection of external biotic stimulus (GO:0098581)3.74103656
30respiratory burst (GO:0045730)3.72449345
31microglial cell activation (GO:0001774)3.62834500
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51353650
33T-helper 1 type immune response (GO:0042088)3.45050718
34B cell receptor signaling pathway (GO:0050853)3.36857429
35response to protozoan (GO:0001562)3.35767413
36regulation of cholesterol storage (GO:0010885)3.34622954
37detection of biotic stimulus (GO:0009595)3.33985296
38regulation of B cell differentiation (GO:0045577)3.30742871
39negative regulation of T cell mediated immunity (GO:0002710)3.30630461
40positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.30354848
41cellular extravasation (GO:0045123)3.30114516
42positive regulation of antigen processing and presentation (GO:0002579)3.29912220
43macrophage activation (GO:0042116)3.28139523
44positive regulation of interferon-beta production (GO:0032728)3.26569924
45regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23541527
46regulation of gamma-delta T cell activation (GO:0046643)3.21772760
47response to muramyl dipeptide (GO:0032495)3.19926975
48myeloid cell activation involved in immune response (GO:0002275)3.17841971
49I-kappaB phosphorylation (GO:0007252)3.17536887
50positive regulation of type 2 immune response (GO:0002830)3.11563670
51regulation of gamma-delta T cell differentiation (GO:0045586)3.11269452
52negative regulation of lymphocyte mediated immunity (GO:0002707)3.10890085
53regulation of interleukin-8 biosynthetic process (GO:0045414)3.10887487
54low-density lipoprotein particle clearance (GO:0034383)3.10682529
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06081737
56positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.05850106
57regulation of mast cell activation (GO:0033003)3.03911169
58production of molecular mediator involved in inflammatory response (GO:0002532)3.03491740
59granulocyte activation (GO:0036230)3.02592049
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01018900
61negative regulation of cell killing (GO:0031342)3.01018900
62cellular response to ethanol (GO:0071361)3.00975034
63neutrophil activation (GO:0042119)3.00702495
64positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.99661703
65positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.97825273
66response to type I interferon (GO:0034340)2.97588822
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95398500
68type I interferon signaling pathway (GO:0060337)2.95321192
69cellular response to type I interferon (GO:0071357)2.95321192
70positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.94825486
71regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94336971
72plasma lipoprotein particle clearance (GO:0034381)2.94142237
73regulation of T-helper 1 cell differentiation (GO:0045625)2.94034160
74regulation of T-helper 2 cell differentiation (GO:0045628)2.91761479
75positive thymic T cell selection (GO:0045059)2.91622275
76myeloid dendritic cell activation (GO:0001773)2.89340464
77protein carboxylation (GO:0018214)2.87766071
78peptidyl-glutamic acid carboxylation (GO:0017187)2.87766071
79B cell mediated immunity (GO:0019724)2.87714045
80negative regulation of interleukin-17 production (GO:0032700)2.87217226
81positive regulation of cellular amide metabolic process (GO:0034250)2.86927615
82regulation of leukocyte degranulation (GO:0043300)2.86515670
83regulation of interleukin-12 production (GO:0032655)2.86371966
84pinocytosis (GO:0006907)2.86256362
85negative regulation of leukocyte mediated immunity (GO:0002704)2.85734038
86triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.84098095
87regulation of superoxide anion generation (GO:0032928)2.81666196
88myeloid dendritic cell differentiation (GO:0043011)2.81409579
89regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.80525414
90cellular response to interferon-gamma (GO:0071346)2.79785932
91interferon-gamma-mediated signaling pathway (GO:0060333)2.79697051
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.79653023
93germinal center formation (GO:0002467)2.79131738
94myeloid leukocyte activation (GO:0002274)2.77120912
95negative regulation of interleukin-12 production (GO:0032695)2.76247130
96regulation of tolerance induction (GO:0002643)2.74992182
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.74356499
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74223945
99natural killer cell mediated cytotoxicity (GO:0042267)2.73472299
100natural killer cell mediated immunity (GO:0002228)2.73472299
101regulation of mast cell degranulation (GO:0043304)2.70708351
102neutrophil mediated immunity (GO:0002446)2.70191479
103regulation of T cell tolerance induction (GO:0002664)2.69962131
104regulation of antigen processing and presentation (GO:0002577)2.69606486
105negative regulation of lipid storage (GO:0010888)2.68351408
106defense response to protozoan (GO:0042832)2.67923606
107positive regulation of chemokine biosynthetic process (GO:0045080)2.66817088
108complement activation, alternative pathway (GO:0006957)2.63722804
109regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.63142043
110phospholipid homeostasis (GO:0055091)2.61805827
111leukocyte aggregation (GO:0070486)2.61744572
112NIK/NF-kappaB signaling (GO:0038061)2.61351097
113positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59804613
114JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59516903
115positive regulation of mast cell activation (GO:0033005)2.58583503
116detection of molecule of bacterial origin (GO:0032490)2.58205474
117fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.57212303
118positive regulation of humoral immune response (GO:0002922)2.53998483
119apoptotic cell clearance (GO:0043277)2.53769610
120hydrogen peroxide biosynthetic process (GO:0050665)2.53654357
121negative regulation of cytokine production involved in immune response (GO:0002719)2.53620538
122regulation of interferon-beta production (GO:0032648)2.52997530
123tolerance induction (GO:0002507)2.52132594
124T cell migration (GO:0072678)2.51971015
125negative regulation of interleukin-6 production (GO:0032715)2.51300492
126regulation of mast cell activation involved in immune response (GO:0033006)2.50611178
127urea metabolic process (GO:0019627)2.50547770
128urea cycle (GO:0000050)2.50547770
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45641747
130positive regulation of mast cell activation involved in immune response (GO:0033008)2.45129683
131positive regulation of mast cell degranulation (GO:0043306)2.45129683
132mature B cell differentiation (GO:0002335)2.44968584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.97145330
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.15059395
3* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.99640189
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.83605323
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.67831553
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.32743214
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29145007
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.28437890
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.12147612
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10764798
11* RXR_22158963_ChIP-Seq_LIVER_Mouse3.03099333
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.90750085
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.86576208
14* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.84586312
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83434079
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82353615
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71312053
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70366539
19* LXR_22158963_ChIP-Seq_LIVER_Mouse2.51430081
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50644185
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.45402711
22* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.35485775
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28563759
24VDR_21846776_ChIP-Seq_THP-1_Human2.25402588
25* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23820338
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18480864
27SCL_19346495_ChIP-Seq_HPC-7_Human2.15903490
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12854169
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98006370
30* MYC_22102868_ChIP-Seq_BL_Human1.94927983
31* VDR_24763502_ChIP-Seq_THP-1_Human1.91380772
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.90750091
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89870761
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88999971
35* SPI1_23547873_ChIP-Seq_NB4_Human1.88828050
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87954191
37RUNX_20019798_ChIP-Seq_JUKART_Human1.87087874
38MAF_26560356_Chip-Seq_TH1_Human1.86954986
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82265613
40SPI1_23127762_ChIP-Seq_K562_Human1.80372896
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78769398
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74325895
43MYB_26560356_Chip-Seq_TH2_Human1.72748395
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.72630842
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68403903
46MYB_26560356_Chip-Seq_TH1_Human1.66221570
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62596223
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61373297
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60014525
50TCF7_22412390_ChIP-Seq_EML_Mouse1.55536436
51PU_27001747_Chip-Seq_BMDM_Mouse1.54228112
52UTX_26944678_Chip-Seq_JUKART_Human1.51130735
53CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50740558
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49384361
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48612590
56* GATA1_22025678_ChIP-Seq_K562_Human1.45168337
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41706629
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39129100
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.35268565
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34033188
61VDR_24787735_ChIP-Seq_THP-1_Human1.32388148
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30769699
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29741580
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.28796268
65* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28693920
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26640956
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25193899
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.17054124
69* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15662697
70GATA3_27048872_Chip-Seq_THYMUS_Human1.14769125
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14689321
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10492691
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09832966
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09439720
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09233324
76KDM2B_26808549_Chip-Seq_DND41_Human1.09220574
77MAF_26560356_Chip-Seq_TH2_Human1.08755127
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08562284
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.08459221
80* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06673018
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05856211
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04881428
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03292806
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02812227
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02657191
86GATA1_19941826_ChIP-Seq_K562_Human1.00421592
87GATA3_26560356_Chip-Seq_TH2_Human0.99612454
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98037480
89LXR_22292898_ChIP-Seq_THP-1_Human0.98009789
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97124955
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95753554
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94597511
93STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94073642
94* GATA2_19941826_ChIP-Seq_K562_Human0.93685533
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91535401
96* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91344768
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87840872
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.86989495
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84916005
100ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83348534
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82528657
102* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81926892
103CLOCK_20551151_ChIP-Seq_293T_Human0.81286806
104* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79190559
105* SMRT_27268052_Chip-Seq_Bcells_Human0.78994529
106TFEB_21752829_ChIP-Seq_HELA_Human0.77922681
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76928606
108SPI1_20517297_ChIP-Seq_HL60_Human0.75658916
109* FOXA2_19822575_ChIP-Seq_HepG2_Human0.75508940
110FOXM1_23109430_ChIP-Seq_U2OS_Human0.75043000
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75017974
112GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74176302
113BCL6_27268052_Chip-Seq_Bcells_Human0.72899821
114TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71820657
115NCOR1_26117541_ChIP-Seq_K562_Human0.71657600
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70153672

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.68021650
2MP0003303_peritoneal_inflammation3.51624172
3MP0009840_abnormal_foam_cell3.23930308
4MP0003436_decreased_susceptibility_to3.08053595
5MP0005058_abnormal_lysosome_morphology2.87095386
6MP0002139_abnormal_hepatobiliary_system2.84028435
7MP0001790_abnormal_immune_system2.74537182
8MP0005387_immune_system_phenotype2.74537182
9MP0003191_abnormal_cellular_cholesterol2.65926610
10MP0009785_altered_susceptibility_to2.61778509
11MP0002419_abnormal_innate_immunity2.60515840
12* MP0001800_abnormal_humoral_immune2.59879445
13MP0006082_CNS_inflammation2.55166276
14MP0005000_abnormal_immune_tolerance2.47651768
15MP0000685_abnormal_immune_system2.45199273
16MP0005360_urolithiasis2.43520765
17* MP0002452_abnormal_antigen_presenting2.37800085
18MP0003300_gastrointestinal_ulcer2.36534845
19MP0005025_abnormal_response_to2.35230505
20MP0003172_abnormal_lysosome_physiology2.26052950
21* MP0002723_abnormal_immune_serum2.19517486
22MP0005464_abnormal_platelet_physiology2.19221719
23MP0004510_myositis2.17930720
24MP0005671_abnormal_response_to2.09636640
25MP0005083_abnormal_biliary_tract2.02326318
26MP0005365_abnormal_bile_salt1.97013357
27MP0002148_abnormal_hypersensitivity_rea1.94454844
28* MP0002420_abnormal_adaptive_immunity1.93195601
29* MP0001819_abnormal_immune_cell1.93050736
30MP0004947_skin_inflammation1.88017877
31MP0003724_increased_susceptibility_to1.79017518
32MP0005085_abnormal_gallbladder_physiolo1.75586589
33MP0001845_abnormal_inflammatory_respons1.72473230
34MP0008469_abnormal_protein_level1.71096613
35MP0009278_abnormal_bone_marrow1.71022153
36MP0000604_amyloidosis1.69771562
37MP0002138_abnormal_hepatobiliary_system1.69256230
38MP0001533_abnormal_skeleton_physiology1.65905604
39MP0002405_respiratory_system_inflammati1.62630417
40MP0000569_abnormal_digit_pigmentation1.56221609
41MP0008875_abnormal_xenobiotic_pharmacok1.54759565
42* MP0000716_abnormal_immune_system1.51947500
43* MP0000689_abnormal_spleen_morphology1.50353262
44MP0003183_abnormal_peptide_metabolism1.49789419
45MP0001853_heart_inflammation1.48635944
46* MP0002398_abnormal_bone_marrow1.48338791
47MP0009764_decreased_sensitivity_to1.48241950
48MP0003252_abnormal_bile_duct1.46451452
49MP0008260_abnormal_autophagy1.44555809
50MP0010329_abnormal_lipoprotein_level1.41909096
51MP0010155_abnormal_intestine_physiology1.41529308
52MP0000609_abnormal_liver_physiology1.38952044
53MP0002166_altered_tumor_susceptibility1.36136395
54* MP0002722_abnormal_immune_system1.25592324
55MP0003075_altered_response_to1.25339187
56* MP0002429_abnormal_blood_cell1.24725285
57MP0003690_abnormal_glial_cell1.21696601
58MP0003828_pulmonary_edema1.21404265
59MP0003448_altered_tumor_morphology1.21121441
60MP0001873_stomach_inflammation1.19789177
61MP0003656_abnormal_erythrocyte_physiolo1.17601949
62MP0009763_increased_sensitivity_to1.17506329
63MP0004883_abnormal_blood_vessel1.15981625
64MP0000343_altered_response_to1.15815241
65MP0005397_hematopoietic_system_phenotyp1.14998466
66MP0001545_abnormal_hematopoietic_system1.14998466
67MP0010307_abnormal_tumor_latency1.12690654
68MP0002132_abnormal_respiratory_system1.12567969
69MP0005310_abnormal_salivary_gland1.10067999
70MP0003705_abnormal_hypodermis_morpholog1.06675810
71MP0005076_abnormal_cell_differentiation1.05743497
72MP0005166_decreased_susceptibility_to1.05370155
73MP0000465_gastrointestinal_hemorrhage1.04266806
74MP0002006_tumorigenesis1.03632831
75MP0008004_abnormal_stomach_pH1.03570288
76MP0009333_abnormal_splenocyte_physiolog1.02674057
77MP0005167_abnormal_blood-brain_barrier1.01250935
78MP0001666_abnormal_nutrient_absorption1.01184415
79MP0005319_abnormal_enzyme/_coenzyme0.98290529
80MP0002998_abnormal_bone_remodeling0.97761989
81MP0003866_abnormal_defecation0.94937020
82MP0000598_abnormal_liver_morphology0.94462598
83MP0003566_abnormal_cell_adhesion0.94433329
84MP0002396_abnormal_hematopoietic_system0.91924053
85MP0002933_joint_inflammation0.91562023
86MP0001851_eye_inflammation0.90532988
87MP0002118_abnormal_lipid_homeostasis0.87938151
88MP0002254_reproductive_system_inflammat0.85602205
89MP0005174_abnormal_tail_pigmentation0.84186167
90MP0005584_abnormal_enzyme/coenzyme_acti0.83866252
91MP0000858_altered_metastatic_potential0.83604268
92MP0003091_abnormal_cell_migration0.83193383
93MP0004808_abnormal_hematopoietic_stem0.81858403
94MP0003453_abnormal_keratinocyte_physiol0.81675497
95MP0003195_calcinosis0.81545254
96MP0002332_abnormal_exercise_endurance0.79803513
97MP0005451_abnormal_body_composition0.79717263
98MP0002877_abnormal_melanocyte_morpholog0.79708687
99MP0003763_abnormal_thymus_physiology0.79663740
100MP0002136_abnormal_kidney_physiology0.79120242
101MP0002928_abnormal_bile_duct0.78821683
102MP0001663_abnormal_digestive_system0.78756855
103MP0009765_abnormal_xenobiotic_induced0.77752904
104MP0005332_abnormal_amino_acid0.74716202
105MP0000249_abnormal_blood_vessel0.74693092
106MP0003806_abnormal_nucleotide_metabolis0.74110820
107MP0005023_abnormal_wound_healing0.71844807
108MP0009643_abnormal_urine_homeostasis0.70329385
109MP0000703_abnormal_thymus_morphology0.68928024
110MP0003045_fibrosis0.67849242
111MP0005164_abnormal_response_to0.65884930
112MP0005075_abnormal_melanosome_morpholog0.65089835
113MP0000371_diluted_coat_color0.64952786
114MP0008873_increased_physiological_sensi0.64792625
115MP0008874_decreased_physiological_sensi0.64030903
116MP0000015_abnormal_ear_pigmentation0.63204107
117MP0005390_skeleton_phenotype0.63046327
118MP0000920_abnormal_myelination0.62710347
119MP0004381_abnormal_hair_follicle0.62474450
120MP0003795_abnormal_bone_structure0.61401104
121MP0006054_spinal_hemorrhage0.60898676
122MP0003221_abnormal_cardiomyocyte_apopto0.59069701

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.29948907
2Recurrent bacterial skin infections (HP:0005406)5.06999726
3Recurrent gram-negative bacterial infections (HP:0005420)4.93755408
4Eczematoid dermatitis (HP:0000976)4.74059140
5Systemic lupus erythematosus (HP:0002725)4.41943862
6Increased cerebral lipofuscin (HP:0011813)4.11288676
7Vacuolated lymphocytes (HP:0001922)3.87643171
8T lymphocytopenia (HP:0005403)3.78617735
9Abnormality of macrophages (HP:0004311)3.75614758
10Complement deficiency (HP:0004431)3.68231096
11Myocardial infarction (HP:0001658)3.62513980
12Increased neuronal autofluorescent lipopigment (HP:0002074)3.49829901
13Abnormality of T cell number (HP:0011839)3.49583525
14Glomerulonephritis (HP:0000099)3.47787365
15Cellulitis (HP:0100658)3.41468846
16Joint hemorrhage (HP:0005261)3.40771210
17Recurrent skin infections (HP:0001581)3.40575909
18Mediastinal lymphadenopathy (HP:0100721)3.30998402
19Colitis (HP:0002583)3.30500401
20Keratoconjunctivitis sicca (HP:0001097)3.30431900
21Recurrent viral infections (HP:0004429)3.26176843
22Elevated erythrocyte sedimentation rate (HP:0003565)3.24729758
23Myositis (HP:0100614)3.23742665
24Panhypogammaglobulinemia (HP:0003139)3.23375030
25Autoimmune thrombocytopenia (HP:0001973)3.21538728
26Gastrointestinal infarctions (HP:0005244)3.19947873
27Encephalitis (HP:0002383)3.17261175
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.14443736
29Recurrent fungal infections (HP:0002841)3.14186046
30Deep venous thrombosis (HP:0002625)3.13330795
31Abnormality of complement system (HP:0005339)3.04633593
32Vasculitis (HP:0002633)3.04086116
33Keratoconjunctivitis (HP:0001096)3.03123367
34Dysostosis multiplex (HP:0000943)3.02218379
35Orchitis (HP:0100796)3.01195608
36Hemoptysis (HP:0002105)2.95092373
37Chronic otitis media (HP:0000389)2.88795643
38Xanthomatosis (HP:0000991)2.88782060
39Inflammation of the large intestine (HP:0002037)2.87206065
40Agammaglobulinemia (HP:0004432)2.84817249
41Gingivitis (HP:0000230)2.84164890
42Gingival bleeding (HP:0000225)2.81656406
43Meningitis (HP:0001287)2.79614335
44Periodontitis (HP:0000704)2.78378534
45Stomatitis (HP:0010280)2.76139198
46Abnormality of B cell number (HP:0010975)2.75923417
47Osteomyelitis (HP:0002754)2.75581578
48Gastrointestinal inflammation (HP:0004386)2.75323072
49B lymphocytopenia (HP:0010976)2.72323587
50Mucopolysacchariduria (HP:0008155)2.66794722
51Urinary glycosaminoglycan excretion (HP:0003541)2.66794722
52Abnormality of liposaccharide metabolism (HP:0010968)2.66324175
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.66324175
54Abnormality of glycolipid metabolism (HP:0010969)2.66324175
55Amyloidosis (HP:0011034)2.64343637
56Retrobulbar optic neuritis (HP:0100654)2.63287952
57Optic neuritis (HP:0100653)2.63287952
58Hematochezia (HP:0002573)2.61765283
59Abnormality of T cells (HP:0002843)2.61391869
60Chronic obstructive pulmonary disease (HP:0006510)2.60838820
61Obstructive lung disease (HP:0006536)2.60838820
62Axonal loss (HP:0003447)2.58681995
63Pustule (HP:0200039)2.57833094
64Abnormality of polysaccharide metabolism (HP:0011012)2.57747528
65Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57747528
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57747528
67Spontaneous hematomas (HP:0007420)2.55392440
68Interstitial pulmonary disease (HP:0006530)2.54103444
69Urticaria (HP:0001025)2.53423612
70Loss of speech (HP:0002371)2.52946440
71Mitral stenosis (HP:0001718)2.51947289
72Gangrene (HP:0100758)2.51520648
73Chest pain (HP:0100749)2.46053877
74Increased IgE level (HP:0003212)2.44211154
75Gastrointestinal stroma tumor (HP:0100723)2.43513784
76Granulocytopenia (HP:0001913)2.41939482
77Abnormality of the common coagulation pathway (HP:0010990)2.41084778
78Prolonged partial thromboplastin time (HP:0003645)2.40782142
79Purpura (HP:0000979)2.38765309
80Nephritis (HP:0000123)2.37140979
81Recurrent bronchitis (HP:0002837)2.37062453
82Arterial thrombosis (HP:0004420)2.36474363
83Abnormality of aromatic amino acid family metabolism (HP:0004338)2.36327969
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35865933
85Hyperlipoproteinemia (HP:0010980)2.35568550
86Intrahepatic cholestasis (HP:0001406)2.35045690
87Hypercholesterolemia (HP:0003124)2.33140005
88Eosinophilia (HP:0001880)2.32947729
89Disinhibition (HP:0000734)2.32571570
90Increased IgM level (HP:0003496)2.31499551
91Sepsis (HP:0100806)2.28581510
92IgM deficiency (HP:0002850)2.28532238
93Abnormality of the pleura (HP:0002103)2.27731540
94Prolonged bleeding time (HP:0003010)2.26366886
95Anorexia (HP:0002039)2.26348766
96Combined immunodeficiency (HP:0005387)2.25443469
97Autoimmune hemolytic anemia (HP:0001890)2.25039968
98Recurrent cutaneous fungal infections (HP:0011370)2.24829689
99Chronic mucocutaneous candidiasis (HP:0002728)2.24829689
100Epistaxis (HP:0000421)2.23082498
101Pulmonary infiltrates (HP:0002113)2.21945437
102Esophageal varix (HP:0002040)2.20489276
103Nasal polyposis (HP:0100582)2.15398444
104Petechiae (HP:0000967)2.15299920
105Prostate neoplasm (HP:0100787)2.15280881
106Severe combined immunodeficiency (HP:0004430)2.14057294
107Lymphopenia (HP:0001888)2.12695010
108Abnormality of the prostate (HP:0008775)2.12531326
109Upper motor neuron abnormality (HP:0002127)2.12059194
110Leukocytosis (HP:0001974)2.10952989
111Pulmonary embolism (HP:0002204)2.10802227
112Recurrent pneumonia (HP:0006532)2.10310406
113Polyneuropathy (HP:0001271)2.09979850
114Tetraparesis (HP:0002273)2.08642248
115Restrictive lung disease (HP:0002091)2.08403934
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05510503
117Papilloma (HP:0012740)2.05315895
118Verrucae (HP:0200043)2.05315895
119Impaired platelet aggregation (HP:0003540)2.04401390
120Abnormal platelet function (HP:0011869)2.04401390
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03535557
122Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03213757
123Abnormality of iron homeostasis (HP:0011031)2.03106664
124Increased serum ferritin (HP:0003281)2.02826517
125Thoracic kyphosis (HP:0002942)2.02100418
126Abnormality of eosinophils (HP:0001879)2.01667630
127Thyroiditis (HP:0100646)2.00669568
128Abnormality of cells of the lymphoid lineage (HP:0012140)1.99819965
129Abnormality of the nasal mucosa (HP:0000433)1.98507149
130Hepatosplenomegaly (HP:0001433)1.98212747
131Recurrent lower respiratory tract infections (HP:0002783)1.98137430
132Hypergammaglobulinemia (HP:0010702)1.97332761
133Menorrhagia (HP:0000132)1.97160040
134Viral hepatitis (HP:0006562)1.97065791
135Emphysema (HP:0002097)1.97016899
136Thrombophlebitis (HP:0004418)1.92423117
137Pathologic fracture (HP:0002756)1.91997487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.06301833
2ERN13.98952807
3TYK23.25167798
4TBK13.07185883
5MAP3K142.96566360
6MAP3K102.86030485
7BLK2.81547490
8RIPK42.67261959
9IRAK32.57494227
10KIT2.56987996
11PRPF4B2.44586781
12CSF1R2.33110304
13IRAK42.27954261
14IKBKE2.20079011
15JAK12.03214588
16TGFBR22.01175328
17TAOK31.91406871
18BMPR21.90727493
19TRIB31.75467356
20CSK1.75307345
21STK101.74660896
22GRK61.65181731
23JAK31.65112772
24FGFR41.63394234
25IKBKB1.63378596
26ZAP701.63047788
27SYK1.62583586
28EPHB11.58515579
29BTK1.54377131
30FES1.50149670
31PKN21.46937903
32MAP3K131.46259494
33PIK3CG1.43171853
34HCK1.40165053
35SIK21.39782037
36CAMK1D1.27819461
37PTK61.25426526
38TAOK21.20470729
39SIK11.20316190
40LYN1.17394168
41IRAK11.16798296
42MAP2K31.16214095
43TAOK11.16005659
44FGR1.13844805
45CHUK1.13276276
46TNK21.12469678
47JAK21.12320306
48LCK1.10834428
49TXK1.10596825
50MATK1.08839983
51NEK91.08636183
52LRRK21.03928501
53MAP3K11.00763221
54CDC42BPA0.95760777
55IRAK20.94886470
56CDK120.91681716
57PIM10.88885094
58CAMK1G0.87401743
59RPS6KA40.85531648
60FGFR30.85477526
61ITK0.83849705
62TTN0.83458785
63FLT30.82532113
64MARK30.81313074
65CDK60.74612106
66TEC0.73235706
67CLK10.73068420
68NME20.72287361
69EGFR0.70465199
70RIPK10.68311579
71MAPK40.67242485
72ACVR1B0.67011685
73YES10.64494870
74EEF2K0.63306436
75MAP3K30.61671111
76KSR20.60737706
77CAMKK20.60533917
78BCKDK0.59481719
79TRPM70.58865487
80STK40.56379663
81MAPK110.55078775
82MOS0.54207466
83CDK40.52011400
84MAP3K110.51689024
85DDR20.50777941
86* ABL10.48419592
87PRKCQ0.46895043
88HIPK20.46823973
89MARK20.46653044
90BMX0.45339764
91PAK40.43953579
92PDK10.43922461
93MAP3K60.42293316
94PRKCD0.41335275
95SCYL20.40863458
96RPS6KA60.40108320
97EPHA30.39376697
98FYN0.39202101
99MAP3K50.39021581
100ABL20.37306524
101PIM20.36272064
102MAPK120.35171056
103PDPK10.35042010
104MAP3K80.34606572
105DYRK1B0.34293527
106KDR0.34239660
107PRKCH0.34126318
108MAP3K20.33786491
109SGK30.33504294
110STK240.32584650
111MAPKAPK20.32240374
112SIK30.31910601
113CDK190.31696433
114SMG10.31689175
115MAPK70.31651827
116RPS6KC10.30668537
117RPS6KL10.30668537
118ALK0.30187937
119MAP2K60.29731982
120SGK20.28624678
121CDK90.28235453
122ADRBK20.27466887
123NLK0.27285536
124TESK20.27170177
125INSR0.26430598
126PRKD20.26061623
127NEK20.26029875
128GSK3A0.25928097
129GRK70.25601943

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.88351516
2Leishmaniasis_Homo sapiens_hsa051402.74520106
3Autoimmune thyroid disease_Homo sapiens_hsa053202.61707144
4* B cell receptor signaling pathway_Homo sapiens_hsa046622.49585283
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.48448197
6Complement and coagulation cascades_Homo sapiens_hsa046102.45825559
7Osteoclast differentiation_Homo sapiens_hsa043802.38819477
8Type I diabetes mellitus_Homo sapiens_hsa049402.27090045
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20881169
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.15346515
11Caffeine metabolism_Homo sapiens_hsa002322.03217378
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.00991272
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94404555
14Lysosome_Homo sapiens_hsa041421.86481214
15Pertussis_Homo sapiens_hsa051331.80727479
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73045327
17Tuberculosis_Homo sapiens_hsa051521.72827511
18Nitrogen metabolism_Homo sapiens_hsa009101.71406685
19Malaria_Homo sapiens_hsa051441.70016477
20Measles_Homo sapiens_hsa051621.61679778
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59948379
22Primary immunodeficiency_Homo sapiens_hsa053401.58829476
23Legionellosis_Homo sapiens_hsa051341.58429718
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.56606054
25Arginine biosynthesis_Homo sapiens_hsa002201.50943917
26Antigen processing and presentation_Homo sapiens_hsa046121.49239951
27Influenza A_Homo sapiens_hsa051641.48620818
28Other glycan degradation_Homo sapiens_hsa005111.46858911
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45034129
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44589218
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38759134
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34229657
33Toxoplasmosis_Homo sapiens_hsa051451.33801381
34TNF signaling pathway_Homo sapiens_hsa046681.28563674
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.27899634
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24114418
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22934340
38Hematopoietic cell lineage_Homo sapiens_hsa046401.20721657
39Apoptosis_Homo sapiens_hsa042101.14877601
40Graft-versus-host disease_Homo sapiens_hsa053321.08558091
41ABC transporters_Homo sapiens_hsa020101.05269622
42Hepatitis C_Homo sapiens_hsa051601.03768043
43Herpes simplex infection_Homo sapiens_hsa051681.02873608
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02552426
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02496879
46Tryptophan metabolism_Homo sapiens_hsa003801.00979536
47PPAR signaling pathway_Homo sapiens_hsa033200.99887984
48Allograft rejection_Homo sapiens_hsa053300.97560433
49African trypanosomiasis_Homo sapiens_hsa051430.94754152
50Shigellosis_Homo sapiens_hsa051310.94666768
51Chemokine signaling pathway_Homo sapiens_hsa040620.94650379
52Phagosome_Homo sapiens_hsa041450.94297675
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.93670739
54Hepatitis B_Homo sapiens_hsa051610.92811004
55Acute myeloid leukemia_Homo sapiens_hsa052210.89076742
56Fatty acid degradation_Homo sapiens_hsa000710.87806221
57Histidine metabolism_Homo sapiens_hsa003400.85920255
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84972757
59Rheumatoid arthritis_Homo sapiens_hsa053230.84671503
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.84149389
61Salmonella infection_Homo sapiens_hsa051320.83314934
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82594593
63Chronic myeloid leukemia_Homo sapiens_hsa052200.81814499
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.81715147
65T cell receptor signaling pathway_Homo sapiens_hsa046600.81153425
66Peroxisome_Homo sapiens_hsa041460.81008881
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80625802
68Asthma_Homo sapiens_hsa053100.79558442
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78305218
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76091133
71Pancreatic cancer_Homo sapiens_hsa052120.75621826
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.75025062
73Epstein-Barr virus infection_Homo sapiens_hsa051690.74615851
74Systemic lupus erythematosus_Homo sapiens_hsa053220.68957454
75Insulin resistance_Homo sapiens_hsa049310.68236444
76Selenocompound metabolism_Homo sapiens_hsa004500.65750242
77Chemical carcinogenesis_Homo sapiens_hsa052040.62648631
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61026025
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60629471
80Amoebiasis_Homo sapiens_hsa051460.60224666
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59970391
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59657116
83Starch and sucrose metabolism_Homo sapiens_hsa005000.58150198
84VEGF signaling pathway_Homo sapiens_hsa043700.56548295
85Lysine degradation_Homo sapiens_hsa003100.55646962
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55434882
87Platelet activation_Homo sapiens_hsa046110.54997477
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.54371015
89beta-Alanine metabolism_Homo sapiens_hsa004100.53909900
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53703967
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.51862068
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51748048
93Prion diseases_Homo sapiens_hsa050200.51722753
94Viral carcinogenesis_Homo sapiens_hsa052030.50264244
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49370515
96Renal cell carcinoma_Homo sapiens_hsa052110.48427257
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48320934
98HTLV-I infection_Homo sapiens_hsa051660.47732550
99Bile secretion_Homo sapiens_hsa049760.47694771
100Fat digestion and absorption_Homo sapiens_hsa049750.46045219
101Type II diabetes mellitus_Homo sapiens_hsa049300.45135922
102HIF-1 signaling pathway_Homo sapiens_hsa040660.44104723
103Viral myocarditis_Homo sapiens_hsa054160.43445615
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43314782
105Non-small cell lung cancer_Homo sapiens_hsa052230.43093886
106Prolactin signaling pathway_Homo sapiens_hsa049170.42866807
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42767365
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42593238
109Dorso-ventral axis formation_Homo sapiens_hsa043200.42267088
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41961129
111Pentose phosphate pathway_Homo sapiens_hsa000300.40364865
112Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40350945
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.39339205
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39087897
115Retinol metabolism_Homo sapiens_hsa008300.38454941
116Glycerolipid metabolism_Homo sapiens_hsa005610.38317488
117FoxO signaling pathway_Homo sapiens_hsa040680.38026738
118Phenylalanine metabolism_Homo sapiens_hsa003600.37705802
119Bladder cancer_Homo sapiens_hsa052190.33795295
120mTOR signaling pathway_Homo sapiens_hsa041500.31274454
121Notch signaling pathway_Homo sapiens_hsa043300.28601105
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.27038988
123Collecting duct acid secretion_Homo sapiens_hsa049660.26808243
124Endocytosis_Homo sapiens_hsa041440.23639024
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22320413
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22290946
127GnRH signaling pathway_Homo sapiens_hsa049120.22010252
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.19042603
129Prostate cancer_Homo sapiens_hsa052150.17570746
130MAPK signaling pathway_Homo sapiens_hsa040100.17498704
131Sphingolipid metabolism_Homo sapiens_hsa006000.15265608
132Endometrial cancer_Homo sapiens_hsa052130.14662466
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.12863253

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