PIK3C2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.06902465
2paraxial mesoderm development (GO:0048339)4.68536331
3pre-miRNA processing (GO:0031054)4.59205686
4cell adhesion mediated by integrin (GO:0033627)4.11147747
5pore complex assembly (GO:0046931)3.92388201
6mitotic sister chromatid cohesion (GO:0007064)3.83703579
7retina vasculature morphogenesis in camera-type eye (GO:0061299)3.69554848
8notochord development (GO:0030903)3.42986623
9regulation of transforming growth factor beta2 production (GO:0032909)3.42724594
10mesodermal cell differentiation (GO:0048333)3.38049267
11anterior/posterior axis specification, embryo (GO:0008595)3.17550800
12negative regulation of DNA repair (GO:0045738)3.10637998
13regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.10451665
14regulation of centriole replication (GO:0046599)3.10231036
15bundle of His cell to Purkinje myocyte communication (GO:0086069)3.09091175
16embryonic foregut morphogenesis (GO:0048617)3.05702631
17artery development (GO:0060840)3.01628182
18response to lipoprotein particle (GO:0055094)2.91212195
19regulation of RNA export from nucleus (GO:0046831)2.90160816
20asymmetric protein localization (GO:0008105)2.86408496
21iron ion import (GO:0097286)2.85629044
22regulation of gene silencing by miRNA (GO:0060964)2.85626159
23regulation of gene silencing by RNA (GO:0060966)2.85626159
24regulation of posttranscriptional gene silencing (GO:0060147)2.85626159
25glomerular visceral epithelial cell development (GO:0072015)2.85185999
26positive regulation of catenin import into nucleus (GO:0035413)2.80924836
27wound healing, spreading of epidermal cells (GO:0035313)2.75232859
28cytoplasmic mRNA processing body assembly (GO:0033962)2.74872998
29positive regulation of osteoblast proliferation (GO:0033690)2.72077734
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.69042793
31regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.67491664
32lymphangiogenesis (GO:0001946)2.67311806
33embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65193739
34positive regulation of SMAD protein import into nucleus (GO:0060391)2.64508189
35renal filtration (GO:0097205)2.64178774
36cellular response to vitamin D (GO:0071305)2.64153110
37gastrulation with mouth forming second (GO:0001702)2.63617312
38wound healing, spreading of cells (GO:0044319)2.63516538
39dorsal/ventral axis specification (GO:0009950)2.62989729
40regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62399692
41protein localization to endosome (GO:0036010)2.60703975
42growth hormone receptor signaling pathway (GO:0060396)2.59436925
43protein localization to kinetochore (GO:0034501)2.58697623
44regulation of protein polyubiquitination (GO:1902914)2.58656723
45prostate gland growth (GO:0060736)2.58023149
46hippo signaling (GO:0035329)2.54898094
47substrate-dependent cell migration (GO:0006929)2.54759268
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.54504995
49regulation of translation, ncRNA-mediated (GO:0045974)2.54504995
50negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54504995
51chondrocyte proliferation (GO:0035988)2.53880572
52insulin-like growth factor receptor signaling pathway (GO:0048009)2.53318969
53COPII vesicle coating (GO:0048208)2.53278585
54response to hepatocyte growth factor (GO:0035728)2.52280751
55cellular response to hepatocyte growth factor stimulus (GO:0035729)2.52280751
56NLS-bearing protein import into nucleus (GO:0006607)2.52136020
57axon ensheathment in central nervous system (GO:0032291)2.51994744
58central nervous system myelination (GO:0022010)2.51994744
59* platelet-derived growth factor receptor signaling pathway (GO:0048008)2.48610943
60histone-serine phosphorylation (GO:0035404)2.48004640
61negative regulation of neurotransmitter secretion (GO:0046929)2.46348796
62positive regulation of hormone biosynthetic process (GO:0046886)2.45733547
63regulation of cardioblast differentiation (GO:0051890)2.45455138
64import into cell (GO:0098657)2.42537324
65regulation of osteoblast proliferation (GO:0033688)2.41985077
66collagen fibril organization (GO:0030199)2.39272805
67radial glial cell differentiation (GO:0060019)2.39221785
68monoubiquitinated protein deubiquitination (GO:0035520)2.39188950
69regulation of centrosome duplication (GO:0010824)2.39022375
70regulation of centrosome cycle (GO:0046605)2.38309201
71glomerular epithelial cell development (GO:0072310)2.38161194
72regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36716974
73protein localization to chromosome, centromeric region (GO:0071459)2.36684250
74apoptotic cell clearance (GO:0043277)2.36200994
75endothelial cell morphogenesis (GO:0001886)2.35875718
76cellular response to vitamin (GO:0071295)2.35642411
77regulation of hippo signaling (GO:0035330)2.35443120
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35285729
79ER overload response (GO:0006983)2.35071329
80gland morphogenesis (GO:0022612)2.34887850
81positive regulation of cellular amide metabolic process (GO:0034250)2.34864129
82gap junction assembly (GO:0016264)2.34365471
83positive regulation of actin filament depolymerization (GO:0030836)2.34126741
84regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.34004705
85positive regulation of p38MAPK cascade (GO:1900745)2.33163708
86apical protein localization (GO:0045176)2.32789734
87regulation of sister chromatid cohesion (GO:0007063)2.32681103
88genitalia morphogenesis (GO:0035112)2.32531156
89positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.32503649
90negative regulation of keratinocyte proliferation (GO:0010839)2.32102344
91hemidesmosome assembly (GO:0031581)2.32062756
92negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.30799378
93positive regulation of smooth muscle cell migration (GO:0014911)2.27450718
94eye photoreceptor cell differentiation (GO:0001754)2.25751507
95photoreceptor cell differentiation (GO:0046530)2.25751507
96protein localization to cell surface (GO:0034394)2.25715802
97lymph vessel development (GO:0001945)2.25240114
98cell migration involved in gastrulation (GO:0042074)2.24549768
99exocrine pancreas development (GO:0031017)2.23613943
100adhesion of symbiont to host cell (GO:0044650)2.23497617
101virion attachment to host cell (GO:0019062)2.23497617
102vascular endothelial growth factor signaling pathway (GO:0038084)2.23159156
103cell migration involved in sprouting angiogenesis (GO:0002042)2.23128316
104lung-associated mesenchyme development (GO:0060484)2.23086740
105ectodermal placode formation (GO:0060788)2.22859634
106lung alveolus development (GO:0048286)2.22853479
107cellular response to growth hormone stimulus (GO:0071378)2.22621676
108positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.22392702
109hepatocyte apoptotic process (GO:0097284)2.22304539
110myelin maintenance (GO:0043217)2.21587097
111UDP-N-acetylglucosamine metabolic process (GO:0006047)2.20778702
112regulation of cell fate specification (GO:0042659)2.20494083
113microtubule anchoring (GO:0034453)2.20468224
114positive regulation of protein localization to plasma membrane (GO:1903078)2.19495119
115lung lobe morphogenesis (GO:0060463)2.18733404
116anterior/posterior axis specification (GO:0009948)2.18430120
117regulation of nucleobase-containing compound transport (GO:0032239)2.18427000
118embryonic axis specification (GO:0000578)2.17627422
119interkinetic nuclear migration (GO:0022027)2.17594195
120tight junction assembly (GO:0070830)2.17243811
121mammary gland development (GO:0030879)2.17148822
122negative regulation of protein localization to plasma membrane (GO:1903077)2.16592035
123ncRNA catabolic process (GO:0034661)2.16423540
124ganglion development (GO:0061548)2.15625659
125regulation of establishment of cell polarity (GO:2000114)2.15476100
126establishment of apical/basal cell polarity (GO:0035089)2.15186740
127Sertoli cell development (GO:0060009)2.15062349
128regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.14503083
129peptidyl-tyrosine autophosphorylation (GO:0038083)2.14483407
130establishment of epithelial cell polarity (GO:0090162)2.14442545
131macroautophagy (GO:0016236)2.14223397
132non-recombinational repair (GO:0000726)2.14103674
133double-strand break repair via nonhomologous end joining (GO:0006303)2.14103674
134I-kappaB phosphorylation (GO:0007252)2.14032844
135extracellular matrix assembly (GO:0085029)2.14007567
136chondrocyte development (GO:0002063)2.13339730
137nuclear pore complex assembly (GO:0051292)2.13282703
138regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.13081033
139positive regulation of mesenchymal cell proliferation (GO:0002053)2.13006619
140negative regulation of anoikis (GO:2000811)2.11955565
141cellular response to cholesterol (GO:0071397)2.10960809
142renal system development (GO:0072001)2.10425632
143regulation of histone H3-K9 methylation (GO:0051570)2.10329958
144substrate adhesion-dependent cell spreading (GO:0034446)2.09740813
145regulation of steroid hormone biosynthetic process (GO:0090030)2.09193891
146negative regulation of fibroblast apoptotic process (GO:2000270)2.09070802
147positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.08471910
148positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.08471910
149positive regulation of mitotic sister chromatid separation (GO:1901970)2.08471910
150lung vasculature development (GO:0060426)2.08370688
151cell surface receptor signaling pathway involved in heart development (GO:0061311)2.08301376
152intestinal epithelial cell development (GO:0060576)2.07558302
153metaphase plate congression (GO:0051310)2.07497122
154morphogenesis of an epithelial sheet (GO:0002011)2.06810925
155early endosome to late endosome transport (GO:0045022)2.06351759
156positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.06196916
157protein targeting to Golgi (GO:0000042)2.05236474
158positive regulation of cell cycle checkpoint (GO:1901978)2.04956234
159regulation of establishment or maintenance of cell polarity (GO:0032878)2.04947539
160prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.04683194
161positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.04583443
162mesenchymal-epithelial cell signaling (GO:0060638)2.04383282
163polarized epithelial cell differentiation (GO:0030859)2.04211018
164establishment of protein localization to Golgi (GO:0072600)2.04007029
165glomerular filtration (GO:0003094)2.03900761
166acrosome assembly (GO:0001675)2.03141607
167sister chromatid segregation (GO:0000819)2.02983090
168mesenchymal cell differentiation (GO:0048762)2.02767935
169biotin metabolic process (GO:0006768)2.02753952
170sister chromatid cohesion (GO:0007062)2.02535544
171lung epithelium development (GO:0060428)2.01607204
172regulation of DNA endoreduplication (GO:0032875)2.01552315
173somite rostral/caudal axis specification (GO:0032525)2.01277349
174regulation of establishment of protein localization to plasma membrane (GO:0090003)2.00345012
175negative regulation of chondrocyte differentiation (GO:0032331)2.00105525
176desmosome organization (GO:0002934)2.00084398
177embryonic pattern specification (GO:0009880)1.99421869
178hyperosmotic salinity response (GO:0042538)1.97071594
179primitive streak formation (GO:0090009)1.97051952
180regulation of DNA methylation (GO:0044030)1.96926384
181mitotic metaphase plate congression (GO:0007080)1.96881851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.74683202
2E2F7_22180533_ChIP-Seq_HELA_Human3.24074581
3CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.03051015
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65682603
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.61873799
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.59889278
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.55175245
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50745739
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.47664591
10AR_21909140_ChIP-Seq_LNCAP_Human2.46059782
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.27577962
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21613063
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14975479
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.14969738
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09288708
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00412003
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96654738
18NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.95622759
19NRF2_20460467_ChIP-Seq_MEFs_Mouse1.95622759
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.89097451
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.88331361
22CJUN_26792858_Chip-Seq_BT549_Human1.85185724
23TP53_16413492_ChIP-PET_HCT116_Human1.85083706
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.84659887
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.83516162
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.82553716
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79236234
28TAF15_26573619_Chip-Seq_HEK293_Human1.75680943
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74127694
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69022920
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.68901936
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.68804467
33TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.68046303
34* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.66689789
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.65716806
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64155982
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63871904
38SALL4_18804426_ChIP-ChIP_XEN_Mouse1.58433009
39GBX2_23144817_ChIP-Seq_PC3_Human1.58038367
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57533433
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.49185164
42IGF1R_20145208_ChIP-Seq_DFB_Human1.49069171
43AHR_22903824_ChIP-Seq_MCF-7_Human1.47758559
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.47423344
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46486452
46* GATA2_21666600_ChIP-Seq_HMVEC_Human1.45298458
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44697152
48TBX3_20139965_ChIP-Seq_ESCs_Mouse1.43741098
49TBX3_20139965_ChIP-Seq_MESCs_Mouse1.43606790
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43424717
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.42617556
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41453147
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41453147
54FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40703951
55* BRD4_25478319_ChIP-Seq_HGPS_Human1.39684743
56SOX2_20726797_ChIP-Seq_SW620_Human1.38260161
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35214431
58TP53_18474530_ChIP-ChIP_U2OS_Human1.34963008
59YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29494931
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28870778
61CLOCK_20551151_ChIP-Seq_293T_Human1.27583704
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.26906941
63TP63_23658742_ChIP-Seq_EP156T_Human1.26705280
64* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26555421
65* STAT3_23295773_ChIP-Seq_U87_Human1.26146350
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25393299
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24142840
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.23190036
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.22947295
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22221257
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22119101
72* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21774757
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17034624
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17034624
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17034624
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16975085
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16970075
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16447171
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16084486
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15180504
81ER_23166858_ChIP-Seq_MCF-7_Human1.14625148
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.13408252
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13341774
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13197332
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13183293
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13165964
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13066095
88FUS_26573619_Chip-Seq_HEK293_Human1.12994623
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12198841
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11791192
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11650269
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11070345
93* CDX2_22108803_ChIP-Seq_LS180_Human1.10182972
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09662963
95RXR_22108803_ChIP-Seq_LS180_Human1.09228291
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08890672
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.08574305
98* GATA4_25053715_ChIP-Seq_YYC3_Human1.08509372
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08009754
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08009754
101P300_19829295_ChIP-Seq_ESCs_Human1.07398145
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07390661
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06553510
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06488011
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.06294838
106EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06171853
107SOX9_26525672_Chip-Seq_HEART_Mouse1.05862187
108ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05741475
109* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05479566
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05296862
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05150626
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04645953
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04320938
114AR_21572438_ChIP-Seq_LNCaP_Human1.04272396
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.02909959
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02852037
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.01537973
118* SMAD4_21799915_ChIP-Seq_A2780_Human1.01247145
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.00936574
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00814997
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99634118
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99633059
123EWS_26573619_Chip-Seq_HEK293_Human0.99233536
124VDR_22108803_ChIP-Seq_LS180_Human0.99170342
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99116477
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.98959607
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98476693
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97945030
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97853812
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97837591
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97790902
132CBP_20019798_ChIP-Seq_JUKART_Human0.97790902
133AR_25329375_ChIP-Seq_VCAP_Human0.97667985
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97508272
135RUNX2_22187159_ChIP-Seq_PCA_Human0.97269861
136* TCF4_23295773_ChIP-Seq_U87_Human0.97062463
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.96760749
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.95682095
139TCF4_22108803_ChIP-Seq_LS180_Human0.95459054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.57620400
2MP0010234_abnormal_vibrissa_follicle3.35912881
3MP0008057_abnormal_DNA_replication3.35544271
4MP0010678_abnormal_skin_adnexa2.94029983
5MP0003300_gastrointestinal_ulcer2.86955885
6MP0004272_abnormal_basement_membrane2.79936347
7MP0009384_cardiac_valve_regurgitation2.50522851
8MP0000569_abnormal_digit_pigmentation2.44228458
9MP0003252_abnormal_bile_duct2.43745442
10MP0000383_abnormal_hair_follicle2.36515914
11MP0005275_abnormal_skin_tensile2.16000112
12MP0005171_absent_coat_pigmentation2.05087166
13MP0003950_abnormal_plasma_membrane2.02797616
14MP0009780_abnormal_chondrocyte_physiolo2.01346390
15MP0003045_fibrosis1.96313216
16MP0005503_abnormal_tendon_morphology1.95905921
17MP0000537_abnormal_urethra_morphology1.87782435
18MP0002877_abnormal_melanocyte_morpholog1.86937312
19MP0006054_spinal_hemorrhage1.86079252
20MP0005248_abnormal_Harderian_gland1.85714896
21MP0003705_abnormal_hypodermis_morpholog1.81568260
22MP0001958_emphysema1.75661723
23MP0003937_abnormal_limbs/digits/tail_de1.72000952
24MP0010030_abnormal_orbit_morphology1.70126610
25MP0003091_abnormal_cell_migration1.66955159
26MP0005257_abnormal_intraocular_pressure1.66219758
27MP0005408_hypopigmentation1.66101470
28MP0002295_abnormal_pulmonary_circulatio1.63673648
29MP0004957_abnormal_blastocyst_morpholog1.63350910
30MP0002084_abnormal_developmental_patter1.61569528
31MP0001299_abnormal_eye_distance/1.61538148
32MP0000462_abnormal_digestive_system1.60864213
33MP0001879_abnormal_lymphatic_vessel1.59482081
34MP0005623_abnormal_meninges_morphology1.57169475
35MP0002928_abnormal_bile_duct1.56749076
36MP0002009_preneoplasia1.54416483
37MP0002896_abnormal_bone_mineralization1.49881700
38MP0010352_gastrointestinal_tract_polyps1.48340750
39MP0003567_abnormal_fetal_cardiomyocyte1.47567483
40MP0001661_extended_life_span1.46271517
41MP0003718_maternal_effect1.44976077
42MP0001672_abnormal_embryogenesis/_devel1.42130081
43MP0005380_embryogenesis_phenotype1.42130081
44MP0002060_abnormal_skin_morphology1.40326634
45MP0010368_abnormal_lymphatic_system1.39184220
46MP0001346_abnormal_lacrimal_gland1.38338435
47MP0003984_embryonic_growth_retardation1.37156242
48MP0003566_abnormal_cell_adhesion1.35626860
49MP0002088_abnormal_embryonic_growth/wei1.34994268
50MP0000579_abnormal_nail_morphology1.34455030
51MP0001286_abnormal_eye_development1.33891755
52MP0002168_other_aberrant_phenotype1.33308085
53MP0004264_abnormal_extraembryonic_tissu1.31886604
54MP0001730_embryonic_growth_arrest1.28826061
55MP0002233_abnormal_nose_morphology1.28778934
56MP0003279_aneurysm1.27580252
57MP0003453_abnormal_keratinocyte_physiol1.27105425
58MP0002138_abnormal_hepatobiliary_system1.25329645
59MP0002085_abnormal_embryonic_tissue1.24927005
60MP0000427_abnormal_hair_cycle1.24846670
61MP0009703_decreased_birth_body1.24751110
62MP0002098_abnormal_vibrissa_morphology1.23999808
63MP0005220_abnormal_exocrine_pancreas1.23794549
64MP0003119_abnormal_digestive_system1.22292229
65MP0009672_abnormal_birth_weight1.21701754
66MP0000516_abnormal_urinary_system1.20034014
67MP0005367_renal/urinary_system_phenotyp1.20034014
68MP0005409_darkened_coat_color1.18188889
69MP0002086_abnormal_extraembryonic_tissu1.18104390
70MP0010094_abnormal_chromosome_stability1.16322770
71MP0005076_abnormal_cell_differentiation1.13548530
72MP0000767_abnormal_smooth_muscle1.13409186
73MP0004197_abnormal_fetal_growth/weight/1.12793586
74MP0002092_abnormal_eye_morphology1.12066044
75MP0004185_abnormal_adipocyte_glucose1.11987444
76MP0002697_abnormal_eye_size1.11040903
77MP0000733_abnormal_muscle_development1.10780166
78MP0001666_abnormal_nutrient_absorption1.09824400
79MP0008932_abnormal_embryonic_tissue1.09533725
80MP0005508_abnormal_skeleton_morphology1.09417546
81MP0000762_abnormal_tongue_morphology1.09040885
82MP0003941_abnormal_skin_development1.08620679
83MP0001697_abnormal_embryo_size1.07897539
84MP0003385_abnormal_body_wall1.07337623
85MP0000566_synostosis1.06910308
86MP0000432_abnormal_head_morphology1.06196035
87MP0005187_abnormal_penis_morphology1.05925479
88MP0000627_abnormal_mammary_gland1.04669296
89MP0010307_abnormal_tumor_latency1.04222888
90MP0003868_abnormal_feces_composition1.02547609
91MP0003890_abnormal_embryonic-extraembry1.02057216
92MP0003195_calcinosis1.01514916
93MP0003935_abnormal_craniofacial_develop1.01228089
94MP0008877_abnormal_DNA_methylation1.00302322
95MP0004084_abnormal_cardiac_muscle1.00280762
96MP0003693_abnormal_embryo_hatching1.00187244
97MP0003077_abnormal_cell_cycle0.98790680
98MP0003690_abnormal_glial_cell0.98195817
99MP0005365_abnormal_bile_salt0.98162330
100MP0001915_intracranial_hemorrhage0.97948831
101MP0001177_atelectasis0.97400526
102MP0005023_abnormal_wound_healing0.97028319
103MP0004134_abnormal_chest_morphology0.94552676
104MP0005360_urolithiasis0.93951029
105MP0005388_respiratory_system_phenotype0.92780746
106MP0002133_abnormal_respiratory_system0.92780746
107MP0000920_abnormal_myelination0.92366113
108MP0006292_abnormal_olfactory_placode0.92081260
109MP0003115_abnormal_respiratory_system0.90454615
110MP0009053_abnormal_anal_canal0.90123183
111MP0002115_abnormal_skeleton_extremities0.88769535
112MP0002111_abnormal_tail_morphology0.88768003
113MP0000428_abnormal_craniofacial_morphol0.88351319
114MP0000613_abnormal_salivary_gland0.88288054
115MP0003755_abnormal_palate_morphology0.88109947
116MP0000647_abnormal_sebaceous_gland0.87366020
117MP0003861_abnormal_nervous_system0.87231259
118MP0009250_abnormal_appendicular_skeleto0.86880565
119MP0002254_reproductive_system_inflammat0.86269998
120MP0002938_white_spotting0.84878539
121MP0002166_altered_tumor_susceptibility0.83850382
122MP0003942_abnormal_urinary_system0.83474503
123MP0000534_abnormal_ureter_morphology0.83202427
124MP0003111_abnormal_nucleus_morphology0.83058689
125MP0000163_abnormal_cartilage_morphology0.82911139
126MP0005391_vision/eye_phenotype0.82198725
127MP0003936_abnormal_reproductive_system0.81428184
128MP0002177_abnormal_outer_ear0.81085412
129MP0000377_abnormal_hair_follicle0.80846672
130MP0003136_yellow_coat_color0.80813236
131MP0005395_other_phenotype0.79562888
132MP0009697_abnormal_copulation0.79526145
133MP0001293_anophthalmia0.79248725
134MP0004233_abnormal_muscle_weight0.78919676
135MP0002925_abnormal_cardiovascular_devel0.78843826
136MP0005084_abnormal_gallbladder_morpholo0.78148412
137MP0002080_prenatal_lethality0.77196220
138MP0003283_abnormal_digestive_organ0.77165433
139MP0001881_abnormal_mammary_gland0.76802284
140MP0002139_abnormal_hepatobiliary_system0.74691136
141MP0000003_abnormal_adipose_tissue0.74140703
142MP0002796_impaired_skin_barrier0.74080269
143MP0003122_maternal_imprinting0.73742017
144MP0000778_abnormal_nervous_system0.71547956
145MP0002234_abnormal_pharynx_morphology0.71385252
146MP0003121_genomic_imprinting0.70830171
147MP0003943_abnormal_hepatobiliary_system0.70229846
148MP0005197_abnormal_uvea_morphology0.70207330
149MP0002109_abnormal_limb_morphology0.68379933

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)3.53553700
2Aortic dissection (HP:0002647)2.89467514
3Atrophic scars (HP:0001075)2.85018011
4Subacute progressive viral hepatitis (HP:0006572)2.82479794
5Arterial tortuosity (HP:0005116)2.78798174
6Vascular tortuosity (HP:0004948)2.73794649
7Aortic aneurysm (HP:0004942)2.72766645
8Hematochezia (HP:0002573)2.72736238
9Osteolytic defects of the hand bones (HP:0009699)2.63667934
10Osteolytic defects of the phalanges of the hand (HP:0009771)2.63667934
11Abnormality of the nasal septum (HP:0000419)2.59228672
12Chromsome breakage (HP:0040012)2.58757773
13Tibial bowing (HP:0002982)2.56591842
14Hypoplasia of the iris (HP:0007676)2.52811748
15Nephroblastoma (Wilms tumor) (HP:0002667)2.50644636
16Hypoplastic labia majora (HP:0000059)2.43748018
17Embryonal renal neoplasm (HP:0011794)2.43730534
18Hepatoblastoma (HP:0002884)2.40315523
19Shallow orbits (HP:0000586)2.39964545
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39264429
21Cerebral aneurysm (HP:0004944)2.37819437
22Volvulus (HP:0002580)2.33449510
23Right ventricular cardiomyopathy (HP:0011663)2.27867909
24Thyroid carcinoma (HP:0002890)2.24967454
25Focal segmental glomerulosclerosis (HP:0000097)2.24575775
26Hypoplastic ischia (HP:0003175)2.24185201
27Abnormality of the ischium (HP:0003174)2.22526757
28Bifid tongue (HP:0010297)2.18521814
29Hypoglycemic seizures (HP:0002173)2.16484868
30Short nail (HP:0001799)2.16401552
31Femoral bowing (HP:0002980)2.15979213
32Bell-shaped thorax (HP:0001591)2.13866561
33Abnormality of the labia majora (HP:0012881)2.11167321
34Malignant gastrointestinal tract tumors (HP:0006749)2.07773015
35Gastrointestinal carcinoma (HP:0002672)2.07773015
36Infantile muscular hypotonia (HP:0008947)2.05952676
37Micronodular cirrhosis (HP:0001413)2.04752846
38Heterotopia (HP:0002282)2.03383884
39Conjugated hyperbilirubinemia (HP:0002908)2.03063348
40Thick nail (HP:0001805)2.02545125
41Biliary tract neoplasm (HP:0100574)2.00493439
42Cutaneous finger syndactyly (HP:0010554)1.99126875
43Soft skin (HP:0000977)1.98391879
44Mitral valve prolapse (HP:0001634)1.97909436
45Flat acetabular roof (HP:0003180)1.95821684
46Aneurysm (HP:0002617)1.94836704
47Colon cancer (HP:0003003)1.94264650
48Supernumerary spleens (HP:0009799)1.94203064
49Abnormal lung lobation (HP:0002101)1.92410134
50Alopecia of scalp (HP:0002293)1.92355253
51Ulnar bowing (HP:0003031)1.92054707
52Myocardial infarction (HP:0001658)1.91967035
53Thin bony cortex (HP:0002753)1.91711918
54Submucous cleft hard palate (HP:0000176)1.90686119
55Coronal craniosynostosis (HP:0004440)1.90429787
56Abnormal foot bone ossification (HP:0010675)1.89883088
57Symptomatic seizures (HP:0011145)1.89069447
58Limited hip movement (HP:0008800)1.88334873
59Abdominal distention (HP:0003270)1.88149004
60Intrahepatic cholestasis (HP:0001406)1.87717785
61Aplasia involving bones of the extremities (HP:0009825)1.87714106
62Aplasia involving bones of the upper limbs (HP:0009823)1.87714106
63Aplasia of the phalanges of the hand (HP:0009802)1.87714106
64Abnormality of the astrocytes (HP:0100707)1.87564997
65Astrocytoma (HP:0009592)1.87564997
66Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86889394
67Abnormal pancreas size (HP:0012094)1.86368574
68Skull defect (HP:0001362)1.86361132
69Cortical dysplasia (HP:0002539)1.86064461
70Esophageal varix (HP:0002040)1.85902730
71Cone-rod dystrophy (HP:0000548)1.85815316
72Preaxial foot polydactyly (HP:0001841)1.85020625
73Rhabdomyosarcoma (HP:0002859)1.84585019
74Macroorchidism (HP:0000053)1.83625759
75Wormian bones (HP:0002645)1.82600918
76Short 4th metacarpal (HP:0010044)1.82163813
77Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82163813
78Hyperglycemia (HP:0003074)1.81013790
79Abnormal biliary tract morphology (HP:0012440)1.80562237
80Abnormality of the distal phalanx of the thumb (HP:0009617)1.79979123
81Protrusio acetabuli (HP:0003179)1.79379807
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.78881936
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78881936
84Stenosis of the external auditory canal (HP:0000402)1.78003241
85Omphalocele (HP:0001539)1.77985906
86Cutaneous syndactyly (HP:0012725)1.76588314
87Pulmonic stenosis (HP:0001642)1.76424060
88Abnormal vertebral ossification (HP:0100569)1.76132671
89Increased nuchal translucency (HP:0010880)1.74666222
90Glomerulosclerosis (HP:0000096)1.73434645
91Papillary thyroid carcinoma (HP:0002895)1.72890210
92Peritonitis (HP:0002586)1.72693700
93Buphthalmos (HP:0000557)1.72386555
94Coarse hair (HP:0002208)1.72296756
95Abnormality of chromosome stability (HP:0003220)1.72108572
96Leiomyosarcoma (HP:0100243)1.71128822
97Uterine leiomyosarcoma (HP:0002891)1.71128822
98Intestinal atresia (HP:0011100)1.71019272
99Missing ribs (HP:0000921)1.70934502
100Abnormality of incisor morphology (HP:0011063)1.70800015
101Turricephaly (HP:0000262)1.70712997
102Cupped ear (HP:0000378)1.70558513
103Transitional cell carcinoma of the bladder (HP:0006740)1.69583745
104Dilatation of the ascending aorta (HP:0005111)1.69462276
105Stomach cancer (HP:0012126)1.68970002
106Hyperinsulinemic hypoglycemia (HP:0000825)1.68697107
107Glioma (HP:0009733)1.68067838
108Absent radius (HP:0003974)1.67639996
109Curly hair (HP:0002212)1.67587663
110Capillary hemangiomas (HP:0005306)1.67517817
111Broad ribs (HP:0000885)1.67128499
112Vertebral arch anomaly (HP:0008438)1.66585536
113Limited elbow extension (HP:0001377)1.66331257
114Mesomelia (HP:0003027)1.66004913
115Aortic regurgitation (HP:0001659)1.65763213
116Fragile skin (HP:0001030)1.64464458
117Hip dysplasia (HP:0001385)1.64450778
118Medulloblastoma (HP:0002885)1.63973321
119Spondylolisthesis (HP:0003302)1.63623012
120Prostate neoplasm (HP:0100787)1.63015242
121Abnormal hand bone ossification (HP:0010660)1.62918286
122Abnormality of dentin (HP:0010299)1.62878263
123Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62824541
124Follicular hyperkeratosis (HP:0007502)1.62744732
125Neoplasm of the oral cavity (HP:0100649)1.62576187
126Tracheal stenosis (HP:0002777)1.62123964
127Overgrowth (HP:0001548)1.62044648
128Absent frontal sinuses (HP:0002688)1.61992703
129Termporal pattern (HP:0011008)1.61331756
130Insidious onset (HP:0003587)1.61331756
131Ependymoma (HP:0002888)1.60907649
132Ankyloglossia (HP:0010296)1.60448134
133Neoplasm of the small intestine (HP:0100833)1.60435344
134Hypopigmentation of the fundus (HP:0007894)1.60362064
135Pancreatic islet-cell hyperplasia (HP:0004510)1.59868562
136Anteriorly placed anus (HP:0001545)1.59682969
137Tubular atrophy (HP:0000092)1.58650612
138Mixed hearing impairment (HP:0000410)1.58366912
139Bladder carcinoma (HP:0002862)1.58361059
140Bladder neoplasm (HP:0009725)1.58361059
141Abnormality of the fibula (HP:0002991)1.58025799
142Hypoplasia of dental enamel (HP:0006297)1.57724881
143Myelomeningocele (HP:0002475)1.57696594
144Midline defect of the nose (HP:0004122)1.56977556
145Aqueductal stenosis (HP:0002410)1.56323207
146Proximal tubulopathy (HP:0000114)1.56318823
147Broad face (HP:0000283)1.56109701
148Cardiovascular calcification (HP:0011915)1.56096847
149Labial hypoplasia (HP:0000066)1.55976160
150Anal stenosis (HP:0002025)1.55906299
151Cervical subluxation (HP:0003308)1.55729076
152Absent eyelashes (HP:0000561)1.54989343
153Absent eyebrow (HP:0002223)1.54904359
154Abnormal ossification of hand bones (HP:0005921)1.54436678
155Abnormality of the middle phalanges of the toes (HP:0010183)1.54202978
156Advanced eruption of teeth (HP:0006288)1.54006125
157Facial cleft (HP:0002006)1.53706825
158Short middle phalanx of finger (HP:0005819)1.53285098
159Milia (HP:0001056)1.53164038
160Aplasia/Hypoplasia of the sternum (HP:0006714)1.52621487
161Xerostomia (HP:0000217)1.52537325
162Abnormality of the right ventricle (HP:0001707)1.52327838
163Narrow palate (HP:0000189)1.52264922
164Broad metatarsal (HP:0001783)1.52141028
165Acute myeloid leukemia (HP:0004808)1.50678643
166Aplasia/Hypoplasia of the tibia (HP:0005772)1.50493495
167Uterine neoplasm (HP:0010784)1.50097662
168Hip contracture (HP:0003273)1.49639368
169Aplasia involving forearm bones (HP:0009822)1.49050659
170Absent forearm bone (HP:0003953)1.49050659
171Gastrointestinal atresia (HP:0002589)1.47592514
172Short humerus (HP:0005792)1.47082500
173Deep philtrum (HP:0002002)1.46148531
174Knee flexion contracture (HP:0006380)1.45249233
175Abnormal auditory evoked potentials (HP:0006958)1.45181799
176Ectopic kidney (HP:0000086)1.44996788
177Neoplasm of striated muscle (HP:0009728)1.44686844
178Abnormality of the antihelix (HP:0009738)1.44059792
179Overlapping toe (HP:0001845)1.43186158
180Abnormality of the epiphyses of the hand (HP:0005924)1.42560211
181Abnormality of chromosome segregation (HP:0002916)1.42439916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.41843163
2FRK4.19529660
3EPHA23.39214119
4INSRR2.76762060
5NUAK12.76414285
6STK392.75212339
7FGFR22.69791474
8MET2.41129338
9EPHB12.39011157
10TTK2.20056387
11PNCK2.06364965
12STK31.97765921
13BRSK21.97507129
14MST41.87892688
15PDGFRA1.87450071
16LATS21.83190634
17BCR1.74580520
18DDR21.67599089
19CAMK1D1.63148272
20SIK11.63103649
21TTN1.62097077
22TSSK61.60607447
23MKNK21.58130435
24CDK121.52670016
25CAMK1G1.51465250
26FER1.50374050
27WNK31.47589257
28NEK91.46424244
29PDGFRB1.45250924
30PTK21.44301081
31PTK61.43423198
32PLK41.42235594
33OXSR11.41660518
34CDC71.41480523
35MKNK11.41434197
36TAF11.41054401
37TGFBR21.36786062
38STK241.36517067
39CASK1.34908353
40TAOK31.31727502
41CSNK1A1L1.30919737
42TNIK1.30085713
43TRPM71.29441456
44ZAK1.28771305
45ERBB41.28654824
46EIF2AK31.24425994
47WNK11.24053353
48PLK31.24047964
49ACVR1B1.20313193
50EPHA31.16860459
51FGFR31.16250778
52MAP3K91.14932308
53PIK3CA1.13783712
54MAP3K21.13473878
55SRPK11.12949703
56PAK31.11472140
57MAP3K141.08945065
58MAP3K41.08039221
59WEE11.06825873
60PBK1.04007911
61RIPK11.01940056
62AKT31.01104255
63EEF2K0.96198634
64STK38L0.93894829
65NEK10.89867062
66JAK10.89469332
67TIE10.89059009
68MST1R0.88810483
69MELK0.88647588
70STK100.88561334
71WNK40.88537394
72NEK60.87614176
73PKN10.87539478
74BMPR1B0.86154421
75CSNK1G10.84239362
76FGFR40.83218775
77CDK60.78108540
78BRD40.77772016
79GSK3A0.77640599
80TGFBR10.77177457
81INSR0.76646624
82YES10.76367621
83MTOR0.76232135
84PLK20.74072957
85FGFR10.73027414
86ERBB20.70688991
87TYRO30.68514442
88FGR0.67872472
89PAK20.67783330
90STK380.67493359
91PLK10.66578361
92MAP3K100.65342658
93MAPK150.65073216
94FLT30.63372202
95ERBB30.63361293
96PRKCE0.61538033
97PRKAA20.60512575
98IGF1R0.60402879
99MARK30.58402626
100EPHB20.58239883
101TRIM280.57009857
102CSNK1E0.56727511
103SGK4940.56362264
104SGK2230.56362264
105CHEK20.56343447
106CSK0.55521872
107CHEK10.54908762
108BMX0.54521998
109NEK20.54141562
110DMPK0.53509200
111CDK90.53324602
112CHUK0.53304096
113ABL10.51431530
114NTRK10.51112085
115PRKD10.50378017
116KSR10.49630637
117* CDK10.48621315
118ITK0.48504680
119AURKB0.46855040
120PIK3CG0.45911845
121EGFR0.44969457
122SGK30.44204946
123CDK30.43714028
124PRKCQ0.43593387
125IRAK30.43501191
126SGK20.43434311
127DYRK1B0.42867695
128ATR0.42547323
129NLK0.42354321
130CSNK1G30.42174006
131HIPK20.42140838
132CSNK1G20.40547050
133CSNK1D0.39552493
134MAPK100.39249501
135PRKAA10.38917155
136SGK10.37519257
137RPS6KB10.37131560
138PRKCH0.36210173
139ROCK10.35696827
140CAMK2B0.35338118
141CAMK2D0.35137395
142SCYL20.34712561
143MAP2K20.33877345
144ATM0.30735478

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.52919288
2Steroid biosynthesis_Homo sapiens_hsa001002.50961265
3ECM-receptor interaction_Homo sapiens_hsa045122.26394632
4Non-homologous end-joining_Homo sapiens_hsa034502.07818384
5Adherens junction_Homo sapiens_hsa045202.06779844
6Sulfur metabolism_Homo sapiens_hsa009202.04519344
7Focal adhesion_Homo sapiens_hsa045101.69748724
8Cell cycle_Homo sapiens_hsa041101.68961271
9Small cell lung cancer_Homo sapiens_hsa052221.61965867
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58755869
11Vitamin B6 metabolism_Homo sapiens_hsa007501.56933518
12Vitamin digestion and absorption_Homo sapiens_hsa049771.51407350
13Propanoate metabolism_Homo sapiens_hsa006401.47955336
14Mineral absorption_Homo sapiens_hsa049781.47134974
15Basal transcription factors_Homo sapiens_hsa030221.46895850
16RNA transport_Homo sapiens_hsa030131.46817951
17Circadian rhythm_Homo sapiens_hsa047101.44254852
18Prostate cancer_Homo sapiens_hsa052151.43371140
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43067121
20Thyroid cancer_Homo sapiens_hsa052161.40225493
21Proteoglycans in cancer_Homo sapiens_hsa052051.38962398
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35123424
23MicroRNAs in cancer_Homo sapiens_hsa052061.32343926
24mRNA surveillance pathway_Homo sapiens_hsa030151.32290614
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29498432
26TGF-beta signaling pathway_Homo sapiens_hsa043501.29458063
27Sphingolipid metabolism_Homo sapiens_hsa006001.28313711
28Tight junction_Homo sapiens_hsa045301.27425045
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26075957
30Nitrogen metabolism_Homo sapiens_hsa009101.24516595
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.24464540
32Protein digestion and absorption_Homo sapiens_hsa049741.22385426
33Dorso-ventral axis formation_Homo sapiens_hsa043201.20060107
34Complement and coagulation cascades_Homo sapiens_hsa046101.19998405
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15836914
36Lysine degradation_Homo sapiens_hsa003101.15066898
37Hippo signaling pathway_Homo sapiens_hsa043901.14419579
38Amoebiasis_Homo sapiens_hsa051461.11882603
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.10347228
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10093929
41Ether lipid metabolism_Homo sapiens_hsa005651.10032046
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09265988
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08994427
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08451212
45Malaria_Homo sapiens_hsa051441.07800681
46Histidine metabolism_Homo sapiens_hsa003401.07770024
47Fanconi anemia pathway_Homo sapiens_hsa034601.07527685
48Basal cell carcinoma_Homo sapiens_hsa052171.04278987
49Mismatch repair_Homo sapiens_hsa034301.02713479
50RNA degradation_Homo sapiens_hsa030181.01629788
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00440934
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.96026485
53Renal cell carcinoma_Homo sapiens_hsa052110.94586902
54Oocyte meiosis_Homo sapiens_hsa041140.93705786
55p53 signaling pathway_Homo sapiens_hsa041150.92696609
56Fatty acid biosynthesis_Homo sapiens_hsa000610.91369972
57Pancreatic cancer_Homo sapiens_hsa052120.90677731
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90507402
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.89428858
60Ovarian steroidogenesis_Homo sapiens_hsa049130.89341922
61Systemic lupus erythematosus_Homo sapiens_hsa053220.88249979
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87022233
63Nucleotide excision repair_Homo sapiens_hsa034200.86918564
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86606507
65ABC transporters_Homo sapiens_hsa020100.86117677
66* Inositol phosphate metabolism_Homo sapiens_hsa005620.85241636
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84606369
68Axon guidance_Homo sapiens_hsa043600.84188295
69Melanoma_Homo sapiens_hsa052180.82977597
70Staphylococcus aureus infection_Homo sapiens_hsa051500.82684095
71One carbon pool by folate_Homo sapiens_hsa006700.81900618
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81822472
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81789222
74Colorectal cancer_Homo sapiens_hsa052100.81368394
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80873673
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78868151
77Type II diabetes mellitus_Homo sapiens_hsa049300.78081780
78TNF signaling pathway_Homo sapiens_hsa046680.77410243
79Protein export_Homo sapiens_hsa030600.77394693
80Toxoplasmosis_Homo sapiens_hsa051450.74771239
81Arginine biosynthesis_Homo sapiens_hsa002200.73117266
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.72639563
83Melanogenesis_Homo sapiens_hsa049160.72137661
84Pathways in cancer_Homo sapiens_hsa052000.72047207
85Fatty acid elongation_Homo sapiens_hsa000620.71472573
86Fat digestion and absorption_Homo sapiens_hsa049750.70618819
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69572202
88Hematopoietic cell lineage_Homo sapiens_hsa046400.69368520
89Renin-angiotensin system_Homo sapiens_hsa046140.69061432
90Pyruvate metabolism_Homo sapiens_hsa006200.68417918
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67033947
92Hedgehog signaling pathway_Homo sapiens_hsa043400.66791768
93Caffeine metabolism_Homo sapiens_hsa002320.65617875
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65406421
95FoxO signaling pathway_Homo sapiens_hsa040680.64630396
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64452873
97Gap junction_Homo sapiens_hsa045400.63874698
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63698921
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63568599
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63307951
101Rap1 signaling pathway_Homo sapiens_hsa040150.63011661
102Insulin resistance_Homo sapiens_hsa049310.62921802
103Chronic myeloid leukemia_Homo sapiens_hsa052200.62912396
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62645537
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62197674
106Hepatitis C_Homo sapiens_hsa051600.61234202
107Glucagon signaling pathway_Homo sapiens_hsa049220.60789320
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60245366
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60087532
110PPAR signaling pathway_Homo sapiens_hsa033200.60012541
111ErbB signaling pathway_Homo sapiens_hsa040120.59092922
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58777899
113* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58564412
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57603347
115Endometrial cancer_Homo sapiens_hsa052130.57364456
116Long-term depression_Homo sapiens_hsa047300.57133103
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.56731528
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56048417
119Ras signaling pathway_Homo sapiens_hsa040140.55830293
120Lysosome_Homo sapiens_hsa041420.55504850
121Phagosome_Homo sapiens_hsa041450.55339055
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55264042
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54608735
124Bladder cancer_Homo sapiens_hsa052190.54174566
125Thyroid hormone synthesis_Homo sapiens_hsa049180.53063866
126Tryptophan metabolism_Homo sapiens_hsa003800.53000610
127Selenocompound metabolism_Homo sapiens_hsa004500.52223583
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52068876
129Bile secretion_Homo sapiens_hsa049760.50858576
130Choline metabolism in cancer_Homo sapiens_hsa052310.50794756
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50386758
132mTOR signaling pathway_Homo sapiens_hsa041500.49789531
133AMPK signaling pathway_Homo sapiens_hsa041520.49738544
134Fatty acid degradation_Homo sapiens_hsa000710.49399106
135Pancreatic secretion_Homo sapiens_hsa049720.48703500
136Glioma_Homo sapiens_hsa052140.48455772
137Insulin signaling pathway_Homo sapiens_hsa049100.48323906
138Wnt signaling pathway_Homo sapiens_hsa043100.48070455
139Glutamatergic synapse_Homo sapiens_hsa047240.48024456
140Viral carcinogenesis_Homo sapiens_hsa052030.47189366
141Retinol metabolism_Homo sapiens_hsa008300.47128973
142Fatty acid metabolism_Homo sapiens_hsa012120.46787766
143Chemical carcinogenesis_Homo sapiens_hsa052040.46624442
144beta-Alanine metabolism_Homo sapiens_hsa004100.46107309
145Platelet activation_Homo sapiens_hsa046110.45586761
146Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45556104
147Salmonella infection_Homo sapiens_hsa051320.45459555
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44629855
149Viral myocarditis_Homo sapiens_hsa054160.44356381
150Rheumatoid arthritis_Homo sapiens_hsa053230.43696854
151Dilated cardiomyopathy_Homo sapiens_hsa054140.43614550
152Linoleic acid metabolism_Homo sapiens_hsa005910.42950794

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