PIK3C2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.15306287
2axon ensheathment in central nervous system (GO:0032291)7.15306287
3negative regulation of protein localization to cell surface (GO:2000009)4.45902638
4long-chain fatty acid biosynthetic process (GO:0042759)4.35917560
5presynaptic membrane organization (GO:0097090)4.33618753
6presynaptic membrane assembly (GO:0097105)4.07087282
7cerebral cortex radially oriented cell migration (GO:0021799)4.07056491
8ensheathment of neurons (GO:0007272)3.94895953
9axon ensheathment (GO:0008366)3.94895953
10myelination (GO:0042552)3.93954385
11bundle of His cell to Purkinje myocyte communication (GO:0086069)3.83322846
12limb bud formation (GO:0060174)3.59648545
13oligodendrocyte differentiation (GO:0048709)3.54802676
14desmosome organization (GO:0002934)3.43584914
15myelin maintenance (GO:0043217)3.42190221
16histone H3-K36 demethylation (GO:0070544)3.34265381
17negative regulation of execution phase of apoptosis (GO:1900118)3.30924377
18cyclic nucleotide catabolic process (GO:0009214)3.28276560
19skeletal muscle adaptation (GO:0043501)3.26200539
20peptidyl-tyrosine autophosphorylation (GO:0038083)3.25392840
21negative regulation of neurotransmitter transport (GO:0051589)3.23821248
22establishment of skin barrier (GO:0061436)3.22645317
23striated muscle atrophy (GO:0014891)3.22354381
24regulation of water loss via skin (GO:0033561)3.21647404
25eye photoreceptor cell differentiation (GO:0001754)3.20195455
26photoreceptor cell differentiation (GO:0046530)3.20195455
27negative regulation of neurotransmitter secretion (GO:0046929)3.17930110
28heart valve formation (GO:0003188)3.16389356
29fatty acid elongation (GO:0030497)3.15044654
30citrulline metabolic process (GO:0000052)3.13314655
31glomerular filtration (GO:0003094)3.11344509
32atrial cardiac muscle cell action potential (GO:0086014)3.10179296
33positive regulation of action potential (GO:0045760)3.07853015
34cell migration in hindbrain (GO:0021535)3.03635195
35regulation of pigment cell differentiation (GO:0050932)3.00416710
36endothelium development (GO:0003158)3.00005401
37auditory receptor cell differentiation (GO:0042491)2.99767115
38cytoplasmic mRNA processing body assembly (GO:0033962)2.98660207
39dendritic spine morphogenesis (GO:0060997)2.95987466
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.94150897
41regulation of NFAT protein import into nucleus (GO:0051532)2.91650424
42cellular response to monoamine stimulus (GO:0071868)2.88684191
43cellular response to catecholamine stimulus (GO:0071870)2.88684191
44neuron cell-cell adhesion (GO:0007158)2.88531836
45negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87334911
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.87255165
47glycerophospholipid catabolic process (GO:0046475)2.84312205
48urea cycle (GO:0000050)2.84009563
49response to monoamine (GO:0071867)2.83858428
50response to catecholamine (GO:0071869)2.83858428
51myelination in peripheral nervous system (GO:0022011)2.83269547
52peripheral nervous system axon ensheathment (GO:0032292)2.83269547
53regulation of actin filament-based movement (GO:1903115)2.82048649
54organ growth (GO:0035265)2.79645603
55cAMP catabolic process (GO:0006198)2.78726615
56positive regulation of gene expression, epigenetic (GO:0045815)2.78491811
57negative regulation of myoblast differentiation (GO:0045662)2.78456599
58citrulline biosynthetic process (GO:0019240)2.78363741
59ear development (GO:0043583)2.78143736
60regulation of collateral sprouting (GO:0048670)2.77168306
61oocyte development (GO:0048599)2.77064430
62central nervous system projection neuron axonogenesis (GO:0021952)2.76958373
63histone H3-K4 methylation (GO:0051568)2.76669942
64establishment of nucleus localization (GO:0040023)2.75748885
65neuron remodeling (GO:0016322)2.75651728
66dendritic spine organization (GO:0097061)2.72148864
67cellular response to epinephrine stimulus (GO:0071872)2.71682592
68forebrain neuron differentiation (GO:0021879)2.69957688
69neuronal ion channel clustering (GO:0045161)2.69276557
70creatine metabolic process (GO:0006600)2.68484962
71cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68393866
72transmission of nerve impulse (GO:0019226)2.67780944
73apical protein localization (GO:0045176)2.65644872
74embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65527035
75positive regulation of Rap GTPase activity (GO:0032854)2.64868625
76regulation of somitogenesis (GO:0014807)2.64661435
77myofibril assembly (GO:0030239)2.63964264
78carnitine shuttle (GO:0006853)2.63855776
79regulation of fatty acid beta-oxidation (GO:0031998)2.62222379
80myoblast fusion (GO:0007520)2.62048153
81gap junction assembly (GO:0016264)2.61925505
82sarcomere organization (GO:0045214)2.61532027
83response to inactivity (GO:0014854)2.61364776
84muscle atrophy (GO:0014889)2.59383171
85layer formation in cerebral cortex (GO:0021819)2.58940527
86response to epinephrine (GO:0071871)2.58393085
87regulation of cardiac muscle cell contraction (GO:0086004)2.58358350
88urea metabolic process (GO:0019627)2.58045732
89adult heart development (GO:0007512)2.57837593
90neuron recognition (GO:0008038)2.57776368
91atrioventricular valve morphogenesis (GO:0003181)2.57762509
92embryonic camera-type eye morphogenesis (GO:0048596)2.54811983
93myotube differentiation (GO:0014902)2.53225892
94lateral sprouting from an epithelium (GO:0060601)2.52854200
95histone H3-K9 modification (GO:0061647)2.52653115
96renal filtration (GO:0097205)2.52641949
97membrane tubulation (GO:0097320)2.51901160
98response to redox state (GO:0051775)2.50502383
99histone lysine demethylation (GO:0070076)2.49884364
100cardiac myofibril assembly (GO:0055003)2.49317644
101glomerulus development (GO:0032835)2.48586642
102central nervous system neuron axonogenesis (GO:0021955)2.48089199
103negative regulation of Rho protein signal transduction (GO:0035024)2.48044213
104multicellular organismal water homeostasis (GO:0050891)2.47920345
105asymmetric protein localization (GO:0008105)2.47201429
106intestinal epithelial cell development (GO:0060576)2.46229730
107nerve growth factor signaling pathway (GO:0038180)2.46182902
108adult walking behavior (GO:0007628)2.45985699
109auditory behavior (GO:0031223)2.44405871
110keratinization (GO:0031424)2.44165596
111positive regulation of CREB transcription factor activity (GO:0032793)2.43254369
112glucocorticoid biosynthetic process (GO:0006704)2.43205888
113L-amino acid import (GO:0043092)2.42868039
114histone H3-K9 methylation (GO:0051567)2.42805897
115pre-miRNA processing (GO:0031054)2.42346457
116regulation of skeletal muscle contraction (GO:0014819)2.40374260
117membrane assembly (GO:0071709)2.39831304
118insulin-like growth factor receptor signaling pathway (GO:0048009)2.39805318
119vocalization behavior (GO:0071625)2.39732421
120syncytium formation by plasma membrane fusion (GO:0000768)2.38318684
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38310734
122positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.38228073
123establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.38141874
124regulation of Cdc42 GTPase activity (GO:0043088)2.37494733
125multicellular organismal signaling (GO:0035637)2.37081093
126skeletal muscle contraction (GO:0003009)2.36984774
127establishment of mitochondrion localization (GO:0051654)2.36346695
128cell differentiation involved in metanephros development (GO:0072202)2.35997011
129regulation of relaxation of muscle (GO:1901077)2.35506987
130response to food (GO:0032094)2.35470141
131histone lysine methylation (GO:0034968)2.35310491
132hair cell differentiation (GO:0035315)2.35119554
133nucleus localization (GO:0051647)2.34812782
134axonal fasciculation (GO:0007413)2.34678655
135Rap protein signal transduction (GO:0032486)2.33795605
136histone demethylation (GO:0016577)2.33041914
137mechanosensory behavior (GO:0007638)2.32648009
138regulation of dendritic spine morphogenesis (GO:0061001)2.32192451
139retina layer formation (GO:0010842)2.31688503
140cell proliferation in forebrain (GO:0021846)2.31124440
141surfactant homeostasis (GO:0043129)2.30585137
142regulation of dendritic spine development (GO:0060998)2.29147696
143positive regulation of respiratory burst (GO:0060267)2.28623641
144stress granule assembly (GO:0034063)2.28550053
145positive regulation of keratinocyte differentiation (GO:0045618)2.27976862
146negative regulation of glial cell proliferation (GO:0060253)2.27837613
147astrocyte development (GO:0014002)2.27553867
148positive regulation of fatty acid beta-oxidation (GO:0032000)2.27523965
149morphogenesis of an epithelial sheet (GO:0002011)2.27048430
150semaphorin-plexin signaling pathway (GO:0071526)2.27021435
151nucleobase catabolic process (GO:0046113)2.25930658
152regulation of membrane repolarization (GO:0060306)2.25588660
153postsynaptic membrane organization (GO:0001941)2.25257654
154cell communication involved in cardiac conduction (GO:0086065)2.24117425
155regulation of cholesterol homeostasis (GO:2000188)2.23672833
156regulation of establishment or maintenance of cell polarity (GO:0032878)2.23249912
157regulation of striated muscle contraction (GO:0006942)2.23204287
158positive regulation of histone deacetylation (GO:0031065)2.23195570
159regulation of endothelial cell chemotaxis (GO:2001026)2.22942544
160vascular endothelial growth factor signaling pathway (GO:0038084)2.22795852
161regulation of Rap GTPase activity (GO:0032317)2.22239930
162endothelial cell differentiation (GO:0045446)2.22133100
163spinal cord development (GO:0021510)2.21913909
164regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.21902162
165peptidyl-lysine dimethylation (GO:0018027)2.21574655
166cardiac chamber formation (GO:0003207)2.21169250
167cytoskeletal anchoring at plasma membrane (GO:0007016)2.20831385
168peptidyl-lysine trimethylation (GO:0018023)2.18514053
169cerebral cortex cell migration (GO:0021795)2.18503023
170positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.18473253
171fatty acid transmembrane transport (GO:1902001)2.18405046
172pyrimidine nucleobase catabolic process (GO:0006208)2.18096688
173histone H3-K4 trimethylation (GO:0080182)2.18087531
174positive regulation by host of viral transcription (GO:0043923)2.17748238
175retina vasculature morphogenesis in camera-type eye (GO:0061299)2.17606384
176lymph vessel development (GO:0001945)2.17061126
177regulation of synapse maturation (GO:0090128)2.16989530
178regulation of histone H3-K27 methylation (GO:0061085)2.16983071
179actomyosin structure organization (GO:0031032)2.16928490
180regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.16076239
181negative regulation of axonogenesis (GO:0050771)2.16072459
182peptidyl-lysine methylation (GO:0018022)2.15786080
183regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.15693020
184labyrinthine layer development (GO:0060711)2.15466693
185microtubule polymerization or depolymerization (GO:0031109)2.15404560
186negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.14763511
187negative regulation of translation, ncRNA-mediated (GO:0040033)2.14763511
188regulation of translation, ncRNA-mediated (GO:0045974)2.14763511
189regulation of ARF protein signal transduction (GO:0032012)2.13972240
190keratinocyte development (GO:0003334)2.13051607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44975695
2GBX2_23144817_ChIP-Seq_PC3_Human3.26036629
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.17639982
4* TFAP2C_20629094_ChIP-Seq_MCF-7_Human3.07092756
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56900461
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50548589
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42673423
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42038570
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.42036026
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41984332
11AR_21572438_ChIP-Seq_LNCaP_Human2.39946106
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.35491784
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32474415
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32474415
15* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.26542655
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.25942049
17* MYC_22102868_ChIP-Seq_BL_Human2.20609854
18RUNX1_27514584_Chip-Seq_MCF-7_Human2.08899776
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07615446
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.06180522
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04508409
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99721327
23* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99695982
24* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.98729879
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.98615006
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.98520270
27* KDM2B_26808549_Chip-Seq_DND41_Human1.96778790
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.96705925
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94270431
30* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93792841
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93401816
32TCF7_22412390_ChIP-Seq_EML_Mouse1.91342356
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.87824584
34TAF15_26573619_Chip-Seq_HEK293_Human1.86470448
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83827471
36DROSHA_22980978_ChIP-Seq_HELA_Human1.81909836
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81772155
38* KDM2B_26808549_Chip-Seq_K562_Human1.81579392
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80587337
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73848377
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71146074
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69957648
43* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.68862360
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68568982
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64827886
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64121722
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63114499
48RACK7_27058665_Chip-Seq_MCF-7_Human1.62548445
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61185945
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60724040
51* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60295218
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.58298216
53* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57354904
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56183980
55SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55382829
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54871105
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53848354
58* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.52243623
59* AHR_22903824_ChIP-Seq_MCF-7_Human1.52030009
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.51912700
61* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51362125
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51309619
63RNF2_27304074_Chip-Seq_NSC_Mouse1.50889767
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46528324
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.45343989
66CTCF_27219007_Chip-Seq_Bcells_Human1.44233094
67P300_19829295_ChIP-Seq_ESCs_Human1.42843347
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.42401383
69VDR_22108803_ChIP-Seq_LS180_Human1.41401141
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40180788
71* ARNT_22903824_ChIP-Seq_MCF-7_Human1.38107524
72* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36811357
73* SMAD4_21799915_ChIP-Seq_A2780_Human1.36415248
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.34715582
75RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34136694
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33925735
77* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33061382
78NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32283751
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.29789236
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29099913
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28579275
82STAT3_23295773_ChIP-Seq_U87_Human1.27837939
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27779093
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25470905
85ER_23166858_ChIP-Seq_MCF-7_Human1.25035564
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24822145
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22722756
88SMC4_20622854_ChIP-Seq_HELA_Human1.22418739
89LXR_22292898_ChIP-Seq_THP-1_Human1.22418544
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22186298
91* CREB1_26743006_Chip-Seq_LNCaP_Human1.21585723
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21177658
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.20733392
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19479446
95GATA6_25053715_ChIP-Seq_YYC3_Human1.18046207
96* NANOG_18555785_Chip-Seq_ESCs_Mouse1.17324446
97E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16852558
98TCF4_23295773_ChIP-Seq_U87_Human1.15995173
99WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15418746
100TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15410390
101* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15365119
102RXR_22108803_ChIP-Seq_LS180_Human1.15044660
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14479693
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14479693
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14017438
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13579796
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12369010
108* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12216193
109RARB_27405468_Chip-Seq_BRAIN_Mouse1.11708209
110* E2F1_18555785_Chip-Seq_ESCs_Mouse1.11540274
111RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11064694
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11018776
113* KLF5_25053715_ChIP-Seq_YYC3_Human1.10981508
114POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10792659
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10434282
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09585669
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09360493
118* FOXA2_19822575_ChIP-Seq_HepG2_Human1.08687942
119* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07929562
120* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07591430
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07566223
122* TBX20_22080862_ChIP-Seq_HEART_Mouse1.07338292
123* TBX20_22328084_ChIP-Seq_HEART_Mouse1.07338292
124PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07152792
125TBL1_22424771_ChIP-Seq_293T_Human1.06720978
126* RING1B_27294783_Chip-Seq_ESCs_Mouse1.06677638
127CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06563431
128* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06394384
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05335680
130ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04912515
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04826188
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.04525517
133ISL1_27105846_Chip-Seq_CPCs_Mouse1.03861646
134* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03338541
135* CMYC_18555785_Chip-Seq_ESCs_Mouse1.03187666
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02465335
137FLI1_27457419_Chip-Seq_LIVER_Mouse1.02232002
138REST_21632747_ChIP-Seq_MESCs_Mouse1.01821255
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01782141
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01693896
141CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01662254
142* AR_19668381_ChIP-Seq_PC3_Human1.01605239
143DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01386844
144* P53_22387025_ChIP-Seq_ESCs_Mouse1.01291488
145* P300_18555785_Chip-Seq_ESCs_Mouse1.00529867
146RUNX2_22187159_ChIP-Seq_PCA_Human1.00153146
147* NFE2_27457419_Chip-Seq_LIVER_Mouse0.99909489
148* TCF4_18268006_ChIP-ChIP_LS174T_Human0.99782395
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99622358
150TP63_22573176_ChIP-Seq_HFKS_Human0.99463337
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99021977
152* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98674247
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98334543
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98077801
155NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97783924
156WDR5_24793694_ChIP-Seq_LNCAP_Human0.97677153
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97622043
158GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97313206
159FUS_26573619_Chip-Seq_HEK293_Human0.97122566
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96984322
161* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96517050
162ZNF263_19887448_ChIP-Seq_K562_Human0.95621576
163KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93715891
164* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90948772
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90826358
166NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89520194
167OCT4_19829295_ChIP-Seq_ESCs_Human0.88607080

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.63610529
2MP0002796_impaired_skin_barrier3.25723385
3MP0005409_darkened_coat_color3.04210538
4MP0003880_abnormal_central_pattern2.98292919
5MP0002009_preneoplasia2.97114532
6MP0000566_synostosis2.86612673
7MP0003136_yellow_coat_color2.75460212
8MP0001486_abnormal_startle_reflex2.69439438
9MP0000920_abnormal_myelination2.58184641
10MP0000778_abnormal_nervous_system2.44554178
11MP0008789_abnormal_olfactory_epithelium2.41499085
12MP0005394_taste/olfaction_phenotype2.39185097
13MP0005499_abnormal_olfactory_system2.39185097
14MP0004264_abnormal_extraembryonic_tissu2.38699604
15MP0003950_abnormal_plasma_membrane2.31320169
16MP0004381_abnormal_hair_follicle2.28280293
17MP0005171_absent_coat_pigmentation2.24110023
18MP0004885_abnormal_endolymph2.17318226
19MP0004742_abnormal_vestibular_system2.15225927
20MP0010368_abnormal_lymphatic_system2.14084541
21MP0002822_catalepsy2.09703660
22MP0006292_abnormal_olfactory_placode2.07519548
23MP0004270_analgesia2.06521327
24MP0002098_abnormal_vibrissa_morphology2.00920958
25MP0005451_abnormal_body_composition1.99960128
26MP0001529_abnormal_vocalization1.96472481
27MP0004859_abnormal_synaptic_plasticity1.93315724
28MP0003787_abnormal_imprinting1.92164283
29MP0002272_abnormal_nervous_system1.91050129
30MP0000537_abnormal_urethra_morphology1.90077784
31MP0004782_abnormal_surfactant_physiolog1.88695136
32MP0005076_abnormal_cell_differentiation1.85588601
33MP0009745_abnormal_behavioral_response1.83588653
34MP0001485_abnormal_pinna_reflex1.80349457
35MP0001188_hyperpigmentation1.80136290
36MP0000003_abnormal_adipose_tissue1.79105704
37MP0005501_abnormal_skin_physiology1.76996206
38MP0005645_abnormal_hypothalamus_physiol1.75760448
39MP0004145_abnormal_muscle_electrophysio1.75591906
40MP0000751_myopathy1.72068177
41MP0004036_abnormal_muscle_relaxation1.67867199
42MP0004215_abnormal_myocardial_fiber1.65769499
43MP0005670_abnormal_white_adipose1.62965472
44MP0005423_abnormal_somatic_nervous1.62510755
45MP0009672_abnormal_birth_weight1.62064282
46MP0001905_abnormal_dopamine_level1.60520652
47MP0003635_abnormal_synaptic_transmissio1.59055236
48MP0000013_abnormal_adipose_tissue1.55505342
49MP0002064_seizures1.55374363
50MP0003137_abnormal_impulse_conducting1.52172126
51MP0000377_abnormal_hair_follicle1.48561519
52MP0004084_abnormal_cardiac_muscle1.46743075
53MP0002138_abnormal_hepatobiliary_system1.45105431
54MP0002572_abnormal_emotion/affect_behav1.44883073
55MP0005646_abnormal_pituitary_gland1.44401806
56MP0003690_abnormal_glial_cell1.42414496
57MP0002837_dystrophic_cardiac_calcinosis1.41643103
58MP0002063_abnormal_learning/memory/cond1.41324853
59MP0004142_abnormal_muscle_tone1.40652420
60MP0004085_abnormal_heartbeat1.37221308
61MP0004130_abnormal_muscle_cell1.36351711
62MP0001984_abnormal_olfaction1.35282747
63MP0005375_adipose_tissue_phenotype1.33178096
64MP0008569_lethality_at_weaning1.31503448
65MP0003763_abnormal_thymus_physiology1.29499086
66MP0009046_muscle_twitch1.28594542
67MP0004858_abnormal_nervous_system1.27491737
68MP0010678_abnormal_skin_adnexa1.23586688
69MP0003938_abnormal_ear_development1.23312738
70MP0002067_abnormal_sensory_capabilities1.21637712
71MP0001963_abnormal_hearing_physiology1.21556093
72MP0000383_abnormal_hair_follicle1.21454819
73MP0002557_abnormal_social/conspecific_i1.21383916
74MP0000026_abnormal_inner_ear1.20114913
75MP0000465_gastrointestinal_hemorrhage1.18589229
76MP0005248_abnormal_Harderian_gland1.18342852
77MP0004484_altered_response_of1.17607651
78MP0002734_abnormal_mechanical_nocicepti1.16868989
79MP0009115_abnormal_fat_cell1.16636133
80MP0006138_congestive_heart_failure1.16595485
81MP0003123_paternal_imprinting1.15581112
82MP0005666_abnormal_adipose_tissue1.13923946
83MP0000749_muscle_degeneration1.13832117
84MP0008057_abnormal_DNA_replication1.12520111
85MP0003646_muscle_fatigue1.10665865
86MP0002233_abnormal_nose_morphology1.09878111
87MP0010630_abnormal_cardiac_muscle1.09261407
88MP0005620_abnormal_muscle_contractility1.08977828
89MP0002972_abnormal_cardiac_muscle1.08685250
90MP0001879_abnormal_lymphatic_vessel1.07685555
91MP0004134_abnormal_chest_morphology1.07520456
92MP0000631_abnormal_neuroendocrine_gland1.07461590
93MP0004087_abnormal_muscle_fiber1.07204173
94MP0002882_abnormal_neuron_morphology1.05621451
95MP0005386_behavior/neurological_phenoty1.05258722
96MP0004924_abnormal_behavior1.05258722
97MP0002166_altered_tumor_susceptibility1.04474843
98MP0001440_abnormal_grooming_behavior1.02866514
99MP0009703_decreased_birth_body1.02846586
100MP0004233_abnormal_muscle_weight1.01661072
101MP0010352_gastrointestinal_tract_polyps1.01006984
102MP0001873_stomach_inflammation1.00815754
103MP0004185_abnormal_adipocyte_glucose1.00807126
104MP0002752_abnormal_somatic_nervous1.00596964
105MP0005330_cardiomyopathy0.98794079
106MP0003937_abnormal_limbs/digits/tail_de0.98727606
107MP0003183_abnormal_peptide_metabolism0.98399397
108MP0001502_abnormal_circadian_rhythm0.97671562
109MP0002249_abnormal_larynx_morphology0.97056233
110MP0000427_abnormal_hair_cycle0.96834011
111MP0000955_abnormal_spinal_cord0.95464120
112MP0002108_abnormal_muscle_morphology0.95299777
113MP0000579_abnormal_nail_morphology0.94534036
114MP0003705_abnormal_hypodermis_morpholog0.94427847
115MP0002229_neurodegeneration0.94100798
116MP0002184_abnormal_innervation0.93945195
117MP0008995_early_reproductive_senescence0.93738385
118MP0002971_abnormal_brown_adipose0.92664638
119MP0001177_atelectasis0.90826091
120MP0000762_abnormal_tongue_morphology0.89816420
121MP0001849_ear_inflammation0.89447539
122MP0000733_abnormal_muscle_development0.89178090
123MP0000049_abnormal_middle_ear0.88900560
124MP0001664_abnormal_digestion0.88682751
125MP0002127_abnormal_cardiovascular_syste0.87538092
126MP0000372_irregular_coat_pigmentation0.87477170
127MP0002066_abnormal_motor_capabilities/c0.87414805
128MP0003385_abnormal_body_wall0.86985446
129MP0003861_abnormal_nervous_system0.85843323
130MP0000462_abnormal_digestive_system0.85628539
131MP0003121_genomic_imprinting0.84382301
132MP0002106_abnormal_muscle_physiology0.83189360
133MP0000477_abnormal_intestine_morphology0.82720916
134MP0003634_abnormal_glial_cell0.82346943
135MP0003453_abnormal_keratinocyte_physiol0.81325529
136MP0004147_increased_porphyrin_level0.80149303
137MP0002102_abnormal_ear_morphology0.80066483
138MP0001346_abnormal_lacrimal_gland0.79867232
139MP0002152_abnormal_brain_morphology0.79850643
140MP0003948_abnormal_gas_homeostasis0.79568314
141MP0003828_pulmonary_edema0.78069799
142MP0009250_abnormal_appendicular_skeleto0.78022422
143MP0001216_abnormal_epidermal_layer0.77421842
144MP0002970_abnormal_white_adipose0.77371044
145MP0003631_nervous_system_phenotype0.77206493
146MP0005167_abnormal_blood-brain_barrier0.77028869
147MP0002088_abnormal_embryonic_growth/wei0.76538570
148MP0003984_embryonic_growth_retardation0.75969760
149MP0003122_maternal_imprinting0.75861414
150MP0005369_muscle_phenotype0.75645177
151MP0000467_abnormal_esophagus_morphology0.75034558
152MP0002089_abnormal_postnatal_growth/wei0.74703789
153MP0004043_abnormal_pH_regulation0.73683978
154MP0002876_abnormal_thyroid_physiology0.73630063
155MP0002277_abnormal_respiratory_mucosa0.73063539
156MP0003632_abnormal_nervous_system0.71903676
157MP0001784_abnormal_fluid_regulation0.71240984
158MP0003868_abnormal_feces_composition0.70392155
159MP0008961_abnormal_basal_metabolism0.69143283
160MP0010030_abnormal_orbit_morphology0.68006451
161MP0000759_abnormal_skeletal_muscle0.67732478
162MP0010770_preweaning_lethality0.67577803
163MP0002082_postnatal_lethality0.67577803
164MP0002081_perinatal_lethality0.67209447
165MP0010769_abnormal_survival0.66024101
166MP0009931_abnormal_skin_appearance0.65931179

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.27784645
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.27784645
3Abnormality of the corticospinal tract (HP:0002492)3.76545071
4Atrial fibrillation (HP:0005110)3.53861344
5Broad-based gait (HP:0002136)3.36183096
6Abnormal auditory evoked potentials (HP:0006958)3.22386395
7Muscle fiber splitting (HP:0003555)3.21382714
8Primary atrial arrhythmia (HP:0001692)3.19668438
9Prolonged QT interval (HP:0001657)3.18857943
10Onion bulb formation (HP:0003383)3.16123130
11Muscle hypertrophy of the lower extremities (HP:0008968)3.14321060
12Abnormality of the fingertips (HP:0001211)3.07510452
13Lip pit (HP:0100267)3.02173170
14Supraventricular tachycardia (HP:0004755)2.98153693
15Sudden death (HP:0001699)2.97947113
16Focal motor seizures (HP:0011153)2.95883512
17Alacrima (HP:0000522)2.95239176
18Obstructive sleep apnea (HP:0002870)2.93010765
19Germ cell neoplasia (HP:0100728)2.92478067
20Absent septum pellucidum (HP:0001331)2.89956683
21Calf muscle hypertrophy (HP:0008981)2.89750914
22Supraventricular arrhythmia (HP:0005115)2.89599881
23Broad face (HP:0000283)2.88242299
24Depressed nasal tip (HP:0000437)2.81206437
25Syncope (HP:0001279)2.80733112
26Neoplasm of the adrenal cortex (HP:0100641)2.79631789
27Agammaglobulinemia (HP:0004432)2.71228365
28Right ventricular cardiomyopathy (HP:0011663)2.70582953
29Curly hair (HP:0002212)2.68288518
30Septo-optic dysplasia (HP:0100842)2.66720633
31Peripheral hypomyelination (HP:0007182)2.66145638
32Abnormality of the septum pellucidum (HP:0007375)2.64435593
33Hyperkalemia (HP:0002153)2.59759908
34Ventricular tachycardia (HP:0004756)2.54923706
35Gastrointestinal stroma tumor (HP:0100723)2.52093176
36Visceral angiomatosis (HP:0100761)2.49767763
37Decreased lacrimation (HP:0000633)2.49013876
38Macroorchidism (HP:0000053)2.45982892
39Hyporeflexia of lower limbs (HP:0002600)2.45142190
40Duplicated collecting system (HP:0000081)2.45074412
41Hyperventilation (HP:0002883)2.44078333
42Hyperacusis (HP:0010780)2.40520311
43Thickened helices (HP:0000391)2.38865332
44Increased IgE level (HP:0003212)2.35926436
45Sensory axonal neuropathy (HP:0003390)2.35307228
46Abnormality of the renal collecting system (HP:0004742)2.34007587
47Spastic gait (HP:0002064)2.31506772
48Stomach cancer (HP:0012126)2.30882109
49Abnormality of the calf musculature (HP:0001430)2.30820975
50Termporal pattern (HP:0011008)2.27797565
51Insidious onset (HP:0003587)2.27797565
52Abnormality of the foot musculature (HP:0001436)2.25297097
53Foot dorsiflexor weakness (HP:0009027)2.24683610
54Hepatoblastoma (HP:0002884)2.20307778
55Neoplasm of the heart (HP:0100544)2.20236483
56Truncal obesity (HP:0001956)2.19964503
57Split foot (HP:0001839)2.17823414
58Absent speech (HP:0001344)2.17561114
59Enlarged penis (HP:0000040)2.15919690
60EMG: neuropathic changes (HP:0003445)2.15310658
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.14437014
62Short 4th metacarpal (HP:0010044)2.14437014
63Abnormality of the ischium (HP:0003174)2.14418380
64Malnutrition (HP:0004395)2.13835307
65Pulmonary artery stenosis (HP:0004415)2.12268390
66Sleep apnea (HP:0010535)2.10541152
67Abnormality of the aortic arch (HP:0012303)2.10362863
68Midline defect of the nose (HP:0004122)2.09966439
69Hemangiomatosis (HP:0007461)2.09153982
70Bowel incontinence (HP:0002607)2.07265223
71Hamartoma (HP:0010566)2.07237749
72Difficulty running (HP:0009046)2.06914346
73Lower limb muscle weakness (HP:0007340)2.06470008
74Lymphangioma (HP:0100764)2.05460522
75Anal stenosis (HP:0002025)2.04599731
76Bronchomalacia (HP:0002780)2.04491086
77Subaortic stenosis (HP:0001682)2.03836005
78Abnormality of the left ventricular outflow tract (HP:0011103)2.03836005
79Febrile seizures (HP:0002373)2.03353618
80Dysmetria (HP:0001310)2.01668500
81High anterior hairline (HP:0009890)2.01473175
82Neonatal hypoglycemia (HP:0001998)2.00737290
83Abnormal EKG (HP:0003115)2.00475705
84Aqueductal stenosis (HP:0002410)2.00344831
85Parakeratosis (HP:0001036)1.99814643
86Cupped ear (HP:0000378)1.99501404
87Neurofibrillary tangles (HP:0002185)1.99425294
88Decreased circulating renin level (HP:0003351)1.99413556
89Scanning speech (HP:0002168)1.98692814
90Decreased motor nerve conduction velocity (HP:0003431)1.98675223
91EMG: myopathic abnormalities (HP:0003458)1.98588723
92Optic nerve hypoplasia (HP:0000609)1.94909167
93Distal lower limb amyotrophy (HP:0008944)1.94588872
94White forelock (HP:0002211)1.94248865
95Abnormality of the distal phalanx of the thumb (HP:0009617)1.92027350
96Ankle clonus (HP:0011448)1.91186610
97Heterotopia (HP:0002282)1.91179513
98Aplasia involving bones of the extremities (HP:0009825)1.90913680
99Aplasia involving bones of the upper limbs (HP:0009823)1.90913680
100Aplasia of the phalanges of the hand (HP:0009802)1.90913680
101Steppage gait (HP:0003376)1.90777771
102Periauricular skin pits (HP:0100277)1.90577338
103Preauricular pit (HP:0004467)1.90577338
104Abnormal large intestine physiology (HP:0012700)1.90349923
105Urethral obstruction (HP:0000796)1.88971028
106Anteriorly placed anus (HP:0001545)1.88552428
107Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88053269
108Trigonocephaly (HP:0000243)1.86525959
109Centrally nucleated skeletal muscle fibers (HP:0003687)1.85546796
110Morphological abnormality of the inner ear (HP:0011390)1.84756387
111Metabolic alkalosis (HP:0200114)1.84169098
112Oligodontia (HP:0000677)1.83197399
113Hemorrhage of the eye (HP:0011885)1.83148727
114Lipoatrophy (HP:0100578)1.82246046
115Laryngomalacia (HP:0001601)1.81929367
116Akinesia (HP:0002304)1.80990679
117Long clavicles (HP:0000890)1.80931837
118Esophageal atresia (HP:0002032)1.80020104
119Abnormality of incisor morphology (HP:0011063)1.79286152
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.78327958
121Spina bifida occulta (HP:0003298)1.78088403
122Muscle fiber inclusion bodies (HP:0100299)1.76692822
123Myokymia (HP:0002411)1.75268101
124Urinary bladder sphincter dysfunction (HP:0002839)1.74169824
125Precocious puberty (HP:0000826)1.74133727
126Nonprogressive disorder (HP:0003680)1.74003971
127Partial agenesis of the corpus callosum (HP:0001338)1.73945788
128Distal arthrogryposis (HP:0005684)1.72613294
129Sparse lateral eyebrow (HP:0005338)1.72501130
130Duplication of thumb phalanx (HP:0009942)1.71908093
131Hyperactive renin-angiotensin system (HP:0000841)1.71784999
132Abnormality of small intestinal villus morphology (HP:0011472)1.71731642
133Villous atrophy (HP:0011473)1.71731642
134Limited hip movement (HP:0008800)1.71488343
135Patchy hypopigmentation of hair (HP:0011365)1.70769335
136Fetal akinesia sequence (HP:0001989)1.70596874
137Dysphonia (HP:0001618)1.69854992
138Tented upper lip vermilion (HP:0010804)1.69691806
139Chin dimple (HP:0010751)1.69197414
140Exercise-induced myalgia (HP:0003738)1.68482784
141Cerebral aneurysm (HP:0004944)1.68064131
142Areflexia of lower limbs (HP:0002522)1.67442490
143Focal seizures (HP:0007359)1.67415180
144Aplasia cutis congenita (HP:0001057)1.67401346
145Hypoplastic left heart (HP:0004383)1.67182812
146Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67068462
147Dysmetric saccades (HP:0000641)1.66910291
148Bradycardia (HP:0001662)1.65606091
149Shawl scrotum (HP:0000049)1.65578438
150Abnormal pancreas size (HP:0012094)1.65448377
151Cerebral hypomyelination (HP:0006808)1.64800305
152Glioma (HP:0009733)1.64696152
153Abnormality of renin-angiotensin system (HP:0000847)1.64627034
154Abnormality of glutamine family amino acid metabolism (HP:0010902)1.64394837
155External ophthalmoplegia (HP:0000544)1.64183454
156Thin bony cortex (HP:0002753)1.64063887
157Oligodactyly (HP:0012165)1.64028776
158Abnormality of the salivary glands (HP:0010286)1.63837792
159Advanced eruption of teeth (HP:0006288)1.63634487
160Micronodular cirrhosis (HP:0001413)1.63259862
161Myopathic facies (HP:0002058)1.62521142
162Dilated cardiomyopathy (HP:0001644)1.62499362
163Xerostomia (HP:0000217)1.62368945
164Flat acetabular roof (HP:0003180)1.61878005
165Ectopic kidney (HP:0000086)1.61404606
166Sandal gap (HP:0001852)1.61071841
167Hypoplasia of the iris (HP:0007676)1.60333436
168Nemaline bodies (HP:0003798)1.59846929
169Abnormal hair whorl (HP:0010721)1.58793712
170Cutaneous finger syndactyly (HP:0010554)1.58378394
171Premature skin wrinkling (HP:0100678)1.58174389
172Abnormality of the nasal septum (HP:0000419)1.57966359
173Hypercortisolism (HP:0001578)1.57878231
174Slow-growing hair (HP:0002217)1.56854784
175Abnormality of hair growth rate (HP:0011363)1.56854784
176Impaired social interactions (HP:0000735)1.56645396
177Abnormal social behavior (HP:0012433)1.56645396
178Long eyelashes (HP:0000527)1.56359696
179Skull defect (HP:0001362)1.55459580
180Asymmetry of the thorax (HP:0001555)1.55291676
181Abnormality of the gastric mucosa (HP:0004295)1.55195560
182Sporadic (HP:0003745)1.55172759
183Hamartoma of the eye (HP:0010568)1.54957315
184Down-sloping shoulders (HP:0200021)1.53340633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.30967916
2MAP3K104.07868640
3CASK3.50049993
4STK393.43048403
5EEF2K3.33826777
6ICK2.75758369
7TRIB32.69705235
8CDK122.68226921
9PKN12.43521994
10SIK12.42370524
11OXSR12.34722282
12MUSK2.33133719
13SMG12.29315218
14MST1R2.09761173
15TIE12.09540849
16RIPK11.97791854
17SGK4941.89377643
18SGK2231.89377643
19EPHA41.89352537
20FGFR41.76480333
21NEK61.75517989
22YES11.72522254
23TNIK1.67240286
24EPHB11.67204166
25BCR1.61876122
26OBSCN1.60130503
27MAPK131.58247902
28BMPR21.56052327
29UHMK11.56025247
30CLK11.55380712
31EPHA21.54462183
32BRD41.54454013
33PHKG11.53240986
34PHKG21.53240986
35TYRO31.51340640
36CSNK1A1L1.51146429
37RPS6KB21.43956745
38EPHA31.43142901
39MARK11.42181147
40GRK11.39038067
41FGFR31.38340463
42AKT31.38122956
43FGFR21.37690050
44WNK11.33751110
45DMPK1.33298760
46INSRR1.31541339
47NUAK11.30418015
48MARK21.29362676
49LATS11.29084376
50MKNK21.27616219
51MTOR1.25092487
52PKN21.21145763
53ROCK21.18213998
54DYRK21.17776581
55CAMK1G1.17125889
56SGK21.15794900
57FER1.13757216
58ERN11.13087952
59SIK31.12165856
60CAMK2B1.12101363
61CSNK1G31.11773122
62MAP2K21.11609045
63PRKD31.11138842
64PDK21.05035129
65PRKD11.03535550
66CAMK2D1.02834907
67CSNK1G11.01295417
68FGR0.98929195
69BMPR1B0.98001016
70TNK20.95962648
71PRKCE0.94063892
72CAMK2A0.92086085
73ADRBK20.91276557
74MAPKAPK50.90146393
75CDC42BPA0.90073739
76MKNK10.89611281
77SGK30.88492850
78PRKAA10.88057202
79EPHB20.87576958
80KDR0.86095574
81NTRK20.85582021
82FRK0.85416119
83CSNK1G20.84382857
84MAPK70.83997771
85PRKCQ0.83417836
86NLK0.82603943
87RPS6KA20.82045158
88MAPK110.80233620
89DYRK1B0.80164801
90MST40.80067309
91ERBB30.79724338
92CDK190.78936232
93CDK50.78115141
94PAK30.78037169
95MAPKAPK30.77674171
96SIK20.76691174
97PTK60.75116237
98PIK3CA0.75043759
99DYRK1A0.74981829
100PRKCH0.74345573
101MYLK0.72828645
102CAMK1D0.70940305
103MAP4K10.69499144
104RPS6KB10.65858192
105CHUK0.64756902
106PRKD20.64518906
107ZAK0.64072595
108PRKCZ0.60854559
109TRPM70.59142453
110MAPK80.58980384
111HIPK20.58611702
112ACVR1B0.58413864
113SGK10.58155546
114BLK0.57785484
115CAMK10.57651992
116ROCK10.57599473
117CAMKK10.57039245
118MAPK120.54601376
119LMTK20.53252948
120CAMK2G0.53029651
121MAPK40.53022698
122CDK90.51179695
123CAMK40.50531012
124PRKG10.50409364
125MAP3K70.49737825
126TTN0.49577427
127CSF1R0.49471579
128MAP2K70.49311184
129CSNK1D0.49014031
130CDK30.48917793
131WNK40.48697358
132TAF10.48247607
133PAK60.48116000
134GSK3B0.47830243
135ERBB20.47621565
136CSNK1A10.47402942
137NTRK30.46844852
138MAPK100.46169651
139PRKAA20.45892555
140FES0.45173092
141STK240.45081925
142MET0.43402042
143FYN0.43111278
144PASK0.42441234
145MAP2K10.41908220
146PRKACA0.41623536
147GRK70.39894279
148PINK10.39151262
149STK110.37592900
150PDGFRB0.36257626
151RPS6KL10.36156354
152RPS6KC10.36156354
153MAPK90.35133449

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.75378137
2Fatty acid elongation_Homo sapiens_hsa000622.50034079
3Axon guidance_Homo sapiens_hsa043602.31624999
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.21731802
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18433785
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09435591
7Morphine addiction_Homo sapiens_hsa050322.01959851
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00208028
9Glutamatergic synapse_Homo sapiens_hsa047241.98074213
10Nicotine addiction_Homo sapiens_hsa050331.97376873
11Arginine biosynthesis_Homo sapiens_hsa002201.86089554
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84349332
13Ether lipid metabolism_Homo sapiens_hsa005651.75011989
14Circadian entrainment_Homo sapiens_hsa047131.68848890
15Endometrial cancer_Homo sapiens_hsa052131.67515476
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67104439
17Dilated cardiomyopathy_Homo sapiens_hsa054141.65296687
18GABAergic synapse_Homo sapiens_hsa047271.64101195
19Serotonergic synapse_Homo sapiens_hsa047261.63485018
20Olfactory transduction_Homo sapiens_hsa047401.63251903
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.61400842
22Thyroid hormone signaling pathway_Homo sapiens_hsa049191.59756838
23Taste transduction_Homo sapiens_hsa047421.57186477
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.47499374
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44689678
26Tight junction_Homo sapiens_hsa045301.43605920
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43129145
28Gastric acid secretion_Homo sapiens_hsa049711.39182678
29Salivary secretion_Homo sapiens_hsa049701.39021933
30Cardiac muscle contraction_Homo sapiens_hsa042601.36152475
31Phototransduction_Homo sapiens_hsa047441.35110848
32Sulfur metabolism_Homo sapiens_hsa009201.34614509
33Glucagon signaling pathway_Homo sapiens_hsa049221.34350951
34AMPK signaling pathway_Homo sapiens_hsa041521.34040431
35Steroid biosynthesis_Homo sapiens_hsa001001.33601404
36Insulin resistance_Homo sapiens_hsa049311.32967833
37Longevity regulating pathway - mammal_Homo sapiens_hsa042111.32907754
38B cell receptor signaling pathway_Homo sapiens_hsa046621.32449894
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31581426
40Insulin signaling pathway_Homo sapiens_hsa049101.30247689
41Cocaine addiction_Homo sapiens_hsa050301.28942973
42Cholinergic synapse_Homo sapiens_hsa047251.28013870
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25324675
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24283798
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23783758
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.23521713
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22602704
48Thyroid cancer_Homo sapiens_hsa052161.21115136
49Bile secretion_Homo sapiens_hsa049761.21071664
50Calcium signaling pathway_Homo sapiens_hsa040201.20413360
51Ovarian steroidogenesis_Homo sapiens_hsa049131.18698643
52Renin secretion_Homo sapiens_hsa049241.18010290
53Circadian rhythm_Homo sapiens_hsa047101.16947926
54mTOR signaling pathway_Homo sapiens_hsa041501.14992851
55Long-term depression_Homo sapiens_hsa047301.14732551
56Dorso-ventral axis formation_Homo sapiens_hsa043201.14717858
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.13108628
58Colorectal cancer_Homo sapiens_hsa052101.13090094
59VEGF signaling pathway_Homo sapiens_hsa043701.11676978
60Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11647871
61Wnt signaling pathway_Homo sapiens_hsa043101.10604796
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09984879
63Gap junction_Homo sapiens_hsa045401.09726276
64Notch signaling pathway_Homo sapiens_hsa043301.09198323
65Oxytocin signaling pathway_Homo sapiens_hsa049211.06840483
66Dopaminergic synapse_Homo sapiens_hsa047281.03858014
67cAMP signaling pathway_Homo sapiens_hsa040241.03512828
68Primary immunodeficiency_Homo sapiens_hsa053401.03460899
69Glycerophospholipid metabolism_Homo sapiens_hsa005641.02359033
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01649976
71Estrogen signaling pathway_Homo sapiens_hsa049151.01648429
72Ras signaling pathway_Homo sapiens_hsa040141.00015160
73Renal cell carcinoma_Homo sapiens_hsa052110.98893721
74Basal cell carcinoma_Homo sapiens_hsa052170.96161391
75ABC transporters_Homo sapiens_hsa020100.95542563
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94870539
77Amphetamine addiction_Homo sapiens_hsa050310.94677468
78ErbB signaling pathway_Homo sapiens_hsa040120.93555616
79Chronic myeloid leukemia_Homo sapiens_hsa052200.91794833
80FoxO signaling pathway_Homo sapiens_hsa040680.90431991
81Mineral absorption_Homo sapiens_hsa049780.88974041
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88446401
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.88142601
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88005462
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87656697
86Long-term potentiation_Homo sapiens_hsa047200.87471478
87Acute myeloid leukemia_Homo sapiens_hsa052210.85138150
88MAPK signaling pathway_Homo sapiens_hsa040100.85078277
89Sphingolipid metabolism_Homo sapiens_hsa006000.83810812
90Melanogenesis_Homo sapiens_hsa049160.83397475
91* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83206177
92Non-small cell lung cancer_Homo sapiens_hsa052230.81950915
93Pancreatic secretion_Homo sapiens_hsa049720.79452189
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78820885
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78498169
96Nitrogen metabolism_Homo sapiens_hsa009100.78432553
97Rap1 signaling pathway_Homo sapiens_hsa040150.77565844
98Linoleic acid metabolism_Homo sapiens_hsa005910.77385235
99GnRH signaling pathway_Homo sapiens_hsa049120.76120361
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.73848540
101Thyroid hormone synthesis_Homo sapiens_hsa049180.73581830
102Glioma_Homo sapiens_hsa052140.72373264
103Fat digestion and absorption_Homo sapiens_hsa049750.70614918
104Glycerolipid metabolism_Homo sapiens_hsa005610.70551655
105Insulin secretion_Homo sapiens_hsa049110.70075588
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69042307
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66380699
108MicroRNAs in cancer_Homo sapiens_hsa052060.66022204
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.65143204
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64359962
111PPAR signaling pathway_Homo sapiens_hsa033200.63999511
112Choline metabolism in cancer_Homo sapiens_hsa052310.63792988
113Prolactin signaling pathway_Homo sapiens_hsa049170.62826021
114Alzheimers disease_Homo sapiens_hsa050100.61435043
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.59557386
116Type II diabetes mellitus_Homo sapiens_hsa049300.59261989
117Histidine metabolism_Homo sapiens_hsa003400.58765107
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58407138
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58134559
120Hedgehog signaling pathway_Homo sapiens_hsa043400.55426591
121Chemokine signaling pathway_Homo sapiens_hsa040620.54568415
122Arachidonic acid metabolism_Homo sapiens_hsa005900.49643656
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.49401090
124Vitamin digestion and absorption_Homo sapiens_hsa049770.49238054
125Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48867892
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48721099
127Pathways in cancer_Homo sapiens_hsa052000.48315037
128Autoimmune thyroid disease_Homo sapiens_hsa053200.46463340
129Hematopoietic cell lineage_Homo sapiens_hsa046400.45863824
130African trypanosomiasis_Homo sapiens_hsa051430.44305672
131Lysine degradation_Homo sapiens_hsa003100.42948782
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.42730205
133Prostate cancer_Homo sapiens_hsa052150.42194396
134Adherens junction_Homo sapiens_hsa045200.42117444
135* Inositol phosphate metabolism_Homo sapiens_hsa005620.42006942
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40957834
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40345405
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.39227501
139Oxidative phosphorylation_Homo sapiens_hsa001900.38629569
140Hippo signaling pathway_Homo sapiens_hsa043900.38312351

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