PIK3C2G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.73612075
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.73612075
3L-phenylalanine metabolic process (GO:0006558)7.31967323
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.31967323
5aromatic amino acid family catabolic process (GO:0009074)6.57783864
6exogenous drug catabolic process (GO:0042738)6.47006525
7epoxygenase P450 pathway (GO:0019373)5.77008414
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.71296254
9tryptophan catabolic process (GO:0006569)5.66415089
10indole-containing compound catabolic process (GO:0042436)5.66415089
11indolalkylamine catabolic process (GO:0046218)5.66415089
12bile acid biosynthetic process (GO:0006699)5.52435098
13kynurenine metabolic process (GO:0070189)5.48100260
14tryptophan metabolic process (GO:0006568)5.40240488
15glyoxylate metabolic process (GO:0046487)5.37287555
16alpha-linolenic acid metabolic process (GO:0036109)5.28275264
17omega-hydroxylase P450 pathway (GO:0097267)5.23891751
18protein carboxylation (GO:0018214)5.12626402
19peptidyl-glutamic acid carboxylation (GO:0017187)5.12626402
20high-density lipoprotein particle remodeling (GO:0034375)5.10955014
21cysteine metabolic process (GO:0006534)5.05701324
22urea cycle (GO:0000050)5.01097731
23urea metabolic process (GO:0019627)5.01097731
24bile acid metabolic process (GO:0008206)4.86941081
25negative regulation of fibrinolysis (GO:0051918)4.86703593
26sulfur amino acid catabolic process (GO:0000098)4.85920162
27complement activation, alternative pathway (GO:0006957)4.85232285
28aromatic amino acid family metabolic process (GO:0009072)4.79802160
29regulation of fibrinolysis (GO:0051917)4.79083227
30regulation of protein activation cascade (GO:2000257)4.76866301
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69645875
32drug metabolic process (GO:0017144)4.61775672
33nitrogen cycle metabolic process (GO:0071941)4.61248729
34serine family amino acid catabolic process (GO:0009071)4.59794537
35homocysteine metabolic process (GO:0050667)4.57525477
36reverse cholesterol transport (GO:0043691)4.51211858
37tyrosine metabolic process (GO:0006570)4.50291304
38regulation of complement activation (GO:0030449)4.42943344
39oxidative demethylation (GO:0070989)4.42204187
40acylglycerol homeostasis (GO:0055090)4.40412025
41triglyceride homeostasis (GO:0070328)4.40412025
42regulation of cholesterol esterification (GO:0010872)4.39266489
43protein-lipid complex remodeling (GO:0034368)4.38102915
44macromolecular complex remodeling (GO:0034367)4.38102915
45plasma lipoprotein particle remodeling (GO:0034369)4.38102915
46phospholipid efflux (GO:0033700)4.37067372
47alpha-amino acid catabolic process (GO:1901606)4.28359471
48regulation of triglyceride catabolic process (GO:0010896)4.27303113
49desmosome organization (GO:0002934)4.25346617
50amino-acid betaine metabolic process (GO:0006577)4.24936131
51positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.24598021
52cellular ketone body metabolic process (GO:0046950)4.17356324
53bile acid and bile salt transport (GO:0015721)4.17029346
54negative regulation of cholesterol transport (GO:0032375)4.14371129
55negative regulation of sterol transport (GO:0032372)4.14371129
56indolalkylamine metabolic process (GO:0006586)4.13982600
57lysine catabolic process (GO:0006554)4.10874347
58lysine metabolic process (GO:0006553)4.10874347
59cholesterol efflux (GO:0033344)4.07329122
60negative regulation of protein activation cascade (GO:2000258)4.04546973
61imidazole-containing compound metabolic process (GO:0052803)4.03635479
62flavonoid metabolic process (GO:0009812)4.02854563
63cellular amino acid catabolic process (GO:0009063)3.98264402
64phenylpropanoid metabolic process (GO:0009698)3.97612508
65plasma lipoprotein particle clearance (GO:0034381)3.96158994
66cellular biogenic amine catabolic process (GO:0042402)3.93815177
67amine catabolic process (GO:0009310)3.93815177
68benzene-containing compound metabolic process (GO:0042537)3.91031708
69coenzyme catabolic process (GO:0009109)3.89320002
70intestinal cholesterol absorption (GO:0030299)3.88033391
71cellular glucuronidation (GO:0052695)3.86534897
72cellular modified amino acid catabolic process (GO:0042219)3.84905181
73glutamate metabolic process (GO:0006536)3.79990206
74establishment of skin barrier (GO:0061436)3.78573298
75plasma lipoprotein particle assembly (GO:0034377)3.77549184
76short-chain fatty acid metabolic process (GO:0046459)3.75602916
77ethanol oxidation (GO:0006069)3.72982774
78glycine metabolic process (GO:0006544)3.71173329
79negative regulation of lipase activity (GO:0060192)3.67029643
80very-low-density lipoprotein particle assembly (GO:0034379)3.66531048
81protein-lipid complex assembly (GO:0065005)3.66093543
82drug transmembrane transport (GO:0006855)3.64927182
83aldehyde catabolic process (GO:0046185)3.63116813
84low-density lipoprotein particle remodeling (GO:0034374)3.62339842
85regulation of bile acid biosynthetic process (GO:0070857)3.62089109
86fibrinolysis (GO:0042730)3.60962116
87drug catabolic process (GO:0042737)3.60700316
88serine family amino acid metabolic process (GO:0009069)3.60452845
89regulation of cholesterol homeostasis (GO:2000188)3.59773785
90ketone body metabolic process (GO:1902224)3.59008268
91organic acid catabolic process (GO:0016054)3.57556290
92carboxylic acid catabolic process (GO:0046395)3.57556290
93dicarboxylic acid biosynthetic process (GO:0043650)3.53972344
94negative regulation of blood coagulation (GO:0030195)3.52587915
95negative regulation of hemostasis (GO:1900047)3.52587915
96heme transport (GO:0015886)3.52068594
97phospholipid homeostasis (GO:0055091)3.52059089
98glucuronate metabolic process (GO:0019585)3.51773869
99uronic acid metabolic process (GO:0006063)3.51773869
100negative regulation of digestive system process (GO:0060457)3.50714591
101cholesterol homeostasis (GO:0042632)3.50104922
102blood coagulation, intrinsic pathway (GO:0007597)3.48462694
103positive regulation of triglyceride lipase activity (GO:0061365)3.48082749
104positive regulation of lipoprotein lipase activity (GO:0051006)3.48082749
105sterol homeostasis (GO:0055092)3.43788758
106negative regulation of fatty acid biosynthetic process (GO:0045717)3.43287699
107positive regulation of lipid catabolic process (GO:0050996)3.42960800
108fatty acid oxidation (GO:0019395)3.41798784
109monocarboxylic acid catabolic process (GO:0072329)3.39987954
110fatty acid beta-oxidation (GO:0006635)3.39752601
111plasma lipoprotein particle organization (GO:0071827)3.39060209
112protein activation cascade (GO:0072376)3.38867433
113linoleic acid metabolic process (GO:0043651)3.37148837
114negative regulation of wound healing (GO:0061045)3.36947832
115hemidesmosome assembly (GO:0031581)3.35782854
116arginine metabolic process (GO:0006525)3.35078542
117alkaloid metabolic process (GO:0009820)3.34979998
118lipid oxidation (GO:0034440)3.34379416
119protein-lipid complex subunit organization (GO:0071825)3.33872953
120complement activation, classical pathway (GO:0006958)3.32836027
121cytolysis (GO:0019835)3.31883163
122S-adenosylmethionine metabolic process (GO:0046500)3.30860871
123regulation of water loss via skin (GO:0033561)3.30475232
124lipoprotein metabolic process (GO:0042157)3.27127770
125hormone catabolic process (GO:0042447)3.26658893
126negative regulation of coagulation (GO:0050819)3.22730592
127bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21140985
128negative regulation of complement activation (GO:0045916)3.19999665
129regulation of humoral immune response (GO:0002920)3.16691197
130regulation of lipoprotein metabolic process (GO:0050746)3.13126637
131complement activation (GO:0006956)3.06374192
132polyketide metabolic process (GO:0030638)3.02382154
133doxorubicin metabolic process (GO:0044598)3.02382154
134daunorubicin metabolic process (GO:0044597)3.02382154
135xenobiotic catabolic process (GO:0042178)2.96484169
136aminoglycoside antibiotic metabolic process (GO:0030647)2.95239011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.55323399
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.45588381
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.42951850
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.01461034
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.78628947
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74126719
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.92739614
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.66718544
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.41293691
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39583423
11GBX2_23144817_ChIP-Seq_PC3_Human2.17447190
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5284909
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88819306
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.87361851
15GATA1_22025678_ChIP-Seq_K562_Human1.86155469
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85462622
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85452313
18VDR_22108803_ChIP-Seq_LS180_Human1.80929536
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79473903
20TAF15_26573619_Chip-Seq_HEK293_Human1.74284223
21AHR_22903824_ChIP-Seq_MCF-7_Human1.72378509
22HTT_18923047_ChIP-ChIP_STHdh_Human1.71690300
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.69607612
24IGF1R_20145208_ChIP-Seq_DFB_Human1.67668589
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.66409822
26* ARNT_22903824_ChIP-Seq_MCF-7_Human1.60222585
27CJUN_26792858_Chip-Seq_BT549_Human1.53297764
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53297244
29* TP63_23658742_ChIP-Seq_EP156T_Human1.52920153
30TP53_18474530_ChIP-ChIP_U2OS_Human1.49181005
31* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46791331
32* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44705419
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44315804
34ER_23166858_ChIP-Seq_MCF-7_Human1.44199486
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43683068
36SMAD4_21799915_ChIP-Seq_A2780_Human1.43593009
37* STAT3_23295773_ChIP-Seq_U87_Human1.40390606
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37894326
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.35986783
40HNF4A_19822575_ChIP-Seq_HepG2_Human1.34743620
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34245754
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33341700
43* P300_19829295_ChIP-Seq_ESCs_Human1.33090631
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32344601
45CBP_20019798_ChIP-Seq_JUKART_Human1.30599819
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30599819
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.30276267
48AR_25329375_ChIP-Seq_VCAP_Human1.28312976
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.27491428
50TCF4_22108803_ChIP-Seq_LS180_Human1.26316310
51GATA4_25053715_ChIP-Seq_YYC3_Human1.26210704
52AR_21572438_ChIP-Seq_LNCaP_Human1.26024376
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.25322481
54* TCF4_23295773_ChIP-Seq_U87_Human1.24650319
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23272861
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22660389
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21844639
58TP53_16413492_ChIP-PET_HCT116_Human1.20107635
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19074934
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.17339426
61* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15443332
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15105382
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14364192
64FUS_26573619_Chip-Seq_HEK293_Human1.13202539
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11460076
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.10109032
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.09057600
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08863845
69CLOCK_20551151_ChIP-Seq_293T_Human1.07298419
70RXR_22108803_ChIP-Seq_LS180_Human1.07029016
71RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06808210
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06486234
73SMAD4_21741376_ChIP-Seq_HESCs_Human1.06232472
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05092424
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.05064156
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05014338
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04832130
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.04550614
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04118180
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03113518
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02666914
82IRF8_22096565_ChIP-ChIP_GC-B_Human1.01858353
83RUNX2_22187159_ChIP-Seq_PCA_Human1.00770012
84HNFA_21074721_ChIP-Seq_CACO-2_Human1.00454757
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00445374
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96626113
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95811033
88FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95306390
89FOXA1_25552417_ChIP-Seq_VCAP_Human0.94213895
90PIAS1_25552417_ChIP-Seq_VCAP_Human0.93160238
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92501011
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92084219
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91866788
94* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87282681
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.86398919
96BCAT_22108803_ChIP-Seq_LS180_Human0.84046868
97SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82077770
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82072350
99AR_20517297_ChIP-Seq_VCAP_Human0.80447965
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78874745
101SOX2_20726797_ChIP-Seq_SW620_Human0.78666752
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74281415
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74189272
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74189272
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73370585
106BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72400059
107PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71966608
108EZH2_27294783_Chip-Seq_NPCs_Mouse0.71905667
109PCGF2_27294783_Chip-Seq_NPCs_Mouse0.67412704
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.67100325
111STAT1_17558387_ChIP-Seq_HELA_Human0.66370517
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65772585
113NFE2_27457419_Chip-Seq_LIVER_Mouse0.65578974
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.64955212
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64844886
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.64814079
117FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.63574270
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63425859
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63237060
120RARA_24833708_ChIP-Seq_LIVER_Mouse0.63151663
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.62030488
122RARB_24833708_ChIP-Seq_LIVER_Mouse0.60632469
123SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.60036358
124PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.59475331
125P53_21459846_ChIP-Seq_SAOS-2_Human0.59202090
126AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59116342
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58234346
128TRIM28_21343339_ChIP-Seq_HEK293_Human0.58067631
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.57460882
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.57319315
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56497319
132OCT4_21477851_ChIP-Seq_ESCs_Mouse0.56426823
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.55394665
134CRX_20693478_ChIP-Seq_RETINA_Mouse0.55198724
135* GATA6_25053715_ChIP-Seq_YYC3_Human0.54654106
136* CBP_21632823_ChIP-Seq_H3396_Human0.54559641
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.54482600
138ESET_19884257_ChIP-Seq_ESCs_Mouse0.52524767
139CDX2_22108803_ChIP-Seq_LS180_Human0.52401285
140CEBPB_22108803_ChIP-Seq_LS180_Human0.51173471
141* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.51118950
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.50472164
143RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50175693
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.49934919
145RARG_19884340_ChIP-ChIP_MEFs_Mouse0.49680987
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.49404659
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48085932
148SMAD1_18555785_Chip-Seq_ESCs_Mouse0.47985772
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46891469
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.46583200
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.44645296
152PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44633096
153ESRRB_18555785_Chip-Seq_ESCs_Mouse0.44566781
154MYC_19915707_ChIP-ChIP_AK7_Human0.44126695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81721245
2MP0005360_urolithiasis6.70054477
3MP0005365_abnormal_bile_salt6.33825179
4MP0005085_abnormal_gallbladder_physiolo6.01001663
5MP0008875_abnormal_xenobiotic_pharmacok4.36566045
6MP0003195_calcinosis4.16341839
7MP0003252_abnormal_bile_duct3.80967720
8MP0003806_abnormal_nucleotide_metabolis3.72914882
9MP0010329_abnormal_lipoprotein_level3.22409632
10MP0005083_abnormal_biliary_tract3.21837859
11MP0005275_abnormal_skin_tensile3.17170320
12MP0008004_abnormal_stomach_pH3.12091227
13MP0001666_abnormal_nutrient_absorption2.89195605
14MP0002138_abnormal_hepatobiliary_system2.74315930
15MP0005332_abnormal_amino_acid2.65642080
16MP0004019_abnormal_vitamin_homeostasis2.56427040
17MP0009840_abnormal_foam_cell2.51402412
18MP0003941_abnormal_skin_development2.25197968
19MP0000566_synostosis2.13575629
20MP0002118_abnormal_lipid_homeostasis2.00485411
21MP0003868_abnormal_feces_composition1.93251701
22MP0000609_abnormal_liver_physiology1.91012251
23MP0001764_abnormal_homeostasis1.76856181
24MP0005220_abnormal_exocrine_pancreas1.75533378
25MP0003191_abnormal_cellular_cholesterol1.75480178
26MP0010678_abnormal_skin_adnexa1.73665052
27MP0000383_abnormal_hair_follicle1.73467398
28MP0005084_abnormal_gallbladder_morpholo1.64242097
29MP0000013_abnormal_adipose_tissue1.56342430
30MP0005319_abnormal_enzyme/_coenzyme1.54506892
31MP0009643_abnormal_urine_homeostasis1.52481426
32MP0005451_abnormal_body_composition1.49794741
33MP0004272_abnormal_basement_membrane1.40952105
34MP0009697_abnormal_copulation1.34481835
35MP0005636_abnormal_mineral_homeostasis1.33841049
36MP0002098_abnormal_vibrissa_morphology1.33709366
37MP0005584_abnormal_enzyme/coenzyme_acti1.25744091
38MP0005377_hearing/vestibular/ear_phenot1.25573047
39MP0003878_abnormal_ear_physiology1.25573047
40MP0002078_abnormal_glucose_homeostasis1.18969985
41MP0005379_endocrine/exocrine_gland_phen1.17009091
42MP0005408_hypopigmentation1.16559063
43MP0005647_abnormal_sex_gland1.16557714
44MP0005501_abnormal_skin_physiology1.16195073
45MP0003045_fibrosis1.12892938
46MP0002282_abnormal_trachea_morphology1.07950014
47MP0003183_abnormal_peptide_metabolism1.07830261
48MP0001216_abnormal_epidermal_layer1.07754559
49MP0002254_reproductive_system_inflammat1.07261433
50MP0001944_abnormal_pancreas_morphology1.06333569
51MP0001756_abnormal_urination1.06261947
52MP0003950_abnormal_plasma_membrane1.05869616
53MP0003186_abnormal_redox_activity1.00284757
54MP0000377_abnormal_hair_follicle0.98893257
55MP0001661_extended_life_span0.97558321
56MP0000598_abnormal_liver_morphology0.94873200
57MP0003959_abnormal_lean_body0.93401824
58MP0010368_abnormal_lymphatic_system0.93368086
59MP0000639_abnormal_adrenal_gland0.92617490
60MP0002909_abnormal_adrenal_gland0.92305206
61MP0000467_abnormal_esophagus_morphology0.89387387
62MP0002928_abnormal_bile_duct0.88678263
63MP0009642_abnormal_blood_homeostasis0.88035401
64MP0001765_abnormal_ion_homeostasis0.86798439
65MP0002837_dystrophic_cardiac_calcinosis0.86197027
66MP0000003_abnormal_adipose_tissue0.85383971
67MP0005410_abnormal_fertilization0.84650202
68MP0002693_abnormal_pancreas_physiology0.84625610
69MP0004043_abnormal_pH_regulation0.83701886
70MP0002876_abnormal_thyroid_physiology0.83475214
71MP0003453_abnormal_keratinocyte_physiol0.80859705
72MP0005334_abnormal_fat_pad0.80365486
73MP0009764_decreased_sensitivity_to0.79924047
74MP0001501_abnormal_sleep_pattern0.79096263
75MP0009763_increased_sensitivity_to0.78942274
76MP0010771_integument_phenotype0.78162902
77MP0008469_abnormal_protein_level0.76059769
78MP0004782_abnormal_surfactant_physiolog0.75119336
79MP0005645_abnormal_hypothalamus_physiol0.74893789
80MP0003953_abnormal_hormone_level0.74716614
81MP0004264_abnormal_extraembryonic_tissu0.73727749
82MP0003011_delayed_dark_adaptation0.73592910
83MP0006036_abnormal_mitochondrial_physio0.72369394
84MP0005023_abnormal_wound_healing0.71740589
85MP0005535_abnormal_body_temperature0.69981440
86MP0005670_abnormal_white_adipose0.69709742
87MP0000647_abnormal_sebaceous_gland0.68666151
88MP0005448_abnormal_energy_balance0.68356115
89MP0005409_darkened_coat_color0.68209964
90MP0000470_abnormal_stomach_morphology0.67950802
91MP0010234_abnormal_vibrissa_follicle0.66946236
92MP0000462_abnormal_digestive_system0.65759084
93MP0003718_maternal_effect0.64167728
94MP0005376_homeostasis/metabolism_phenot0.64077206
95MP0003879_abnormal_hair_cell0.62970063
96MP0002971_abnormal_brown_adipose0.62911620
97MP0000604_amyloidosis0.62368852
98MP0009765_abnormal_xenobiotic_induced0.62025532
99MP0002136_abnormal_kidney_physiology0.61402583
100MP0001664_abnormal_digestion0.61121872
101MP0005187_abnormal_penis_morphology0.60653639
102MP0008057_abnormal_DNA_replication0.60186121
103MP0010386_abnormal_urinary_bladder0.59948725
104MP0005248_abnormal_Harderian_gland0.59840864
105MP0009384_cardiac_valve_regurgitation0.59110745
106MP0003705_abnormal_hypodermis_morpholog0.59033261
107MP0004130_abnormal_muscle_cell0.58991899
108MP0003638_abnormal_response/metabolism_0.58603078
109MP0005551_abnormal_eye_electrophysiolog0.58309251
110MP0000538_abnormal_urinary_bladder0.56164729
111MP0000367_abnormal_coat/_hair0.55977572
112MP0003300_gastrointestinal_ulcer0.55718417
113MP0000230_abnormal_systemic_arterial0.54691962
114MP0003656_abnormal_erythrocyte_physiolo0.54495925
115MP0010352_gastrointestinal_tract_polyps0.54045986
116MP0000613_abnormal_salivary_gland0.52949394
117MP0005375_adipose_tissue_phenotype0.52379188
118MP0002796_impaired_skin_barrier0.51925023
119MP0002168_other_aberrant_phenotype0.51426365
120MP0001958_emphysema0.51062355
121MP0001984_abnormal_olfaction0.49443750
122MP0004381_abnormal_hair_follicle0.49259651
123MP0001881_abnormal_mammary_gland0.49143716
124MP0005395_other_phenotype0.48193622
125MP0009931_abnormal_skin_appearance0.48190724
126MP0003566_abnormal_cell_adhesion0.46718839
127MP0005266_abnormal_metabolism0.44934985
128MP0005058_abnormal_lysosome_morphology0.44148317
129MP0001485_abnormal_pinna_reflex0.41920741
130MP0001851_eye_inflammation0.40966806
131MP0003724_increased_susceptibility_to0.40241128
132MP0000762_abnormal_tongue_morphology0.39939085
133MP0008438_abnormal_cutaneous_collagen0.39667042
134MP0002060_abnormal_skin_morphology0.39099248
135MP0003690_abnormal_glial_cell0.37539211
136MP0000427_abnormal_hair_cycle0.37496751
137MP0005666_abnormal_adipose_tissue0.36411359
138MP0009053_abnormal_anal_canal0.34631301
139MP0006035_abnormal_mitochondrial_morpho0.34606880
140MP0000579_abnormal_nail_morphology0.34058544
141MP0002877_abnormal_melanocyte_morpholog0.34031586
142MP0002896_abnormal_bone_mineralization0.33925203
143MP0009780_abnormal_chondrocyte_physiolo0.32903342

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.31920562
2Intrahepatic cholestasis (HP:0001406)7.07051232
3Deep venous thrombosis (HP:0002625)6.15021618
4Prolonged partial thromboplastin time (HP:0003645)6.04766702
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.91105101
6Xanthomatosis (HP:0000991)5.68312001
7Hypobetalipoproteinemia (HP:0003563)5.59845464
8Hypoglycemic coma (HP:0001325)5.43472394
9Ketosis (HP:0001946)4.70645164
10Hyperlipoproteinemia (HP:0010980)4.68141156
11Complement deficiency (HP:0004431)4.61644855
12Conjugated hyperbilirubinemia (HP:0002908)4.54660830
13Joint hemorrhage (HP:0005261)4.48865917
14Hypoglycemic seizures (HP:0002173)4.39332161
15Abnormality of the common coagulation pathway (HP:0010990)4.36884006
16Epidermoid cyst (HP:0200040)4.23131515
17Ketoacidosis (HP:0001993)4.21228363
18Fat malabsorption (HP:0002630)4.18286183
19Hyperglycinemia (HP:0002154)4.17274019
20Abnormality of the intrinsic pathway (HP:0010989)4.15673577
21Hypolipoproteinemia (HP:0010981)4.11953165
22Hyperinsulinemic hypoglycemia (HP:0000825)4.07162229
23Hyperammonemia (HP:0001987)3.99078361
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78362152
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.72038480
26Symptomatic seizures (HP:0011145)3.70273086
27Hyperglycinuria (HP:0003108)3.66446909
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63699110
29Abnormality of methionine metabolism (HP:0010901)3.62705026
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.59443647
31Abnormality of serine family amino acid metabolism (HP:0010894)3.57901075
32Abnormality of glycine metabolism (HP:0010895)3.57901075
33Hypoalphalipoproteinemia (HP:0003233)3.48277266
34Hypercholesterolemia (HP:0003124)3.34500652
35Abnormality of complement system (HP:0005339)3.25382234
36Late onset (HP:0003584)3.24273479
37Hyperglycemia (HP:0003074)3.23131058
38Abnormality of pyrimidine metabolism (HP:0004353)3.18297429
39Skin nodule (HP:0200036)3.17603853
40Hyperbilirubinemia (HP:0002904)3.16982552
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15495215
42Abnormality of fatty-acid metabolism (HP:0004359)3.12474588
43Potter facies (HP:0002009)3.09822011
44Facial shape deformation (HP:0011334)3.09822011
45Plantar hyperkeratosis (HP:0007556)3.09208872
46Fair hair (HP:0002286)3.08460484
47Nephritis (HP:0000123)2.93888152
48Abnormality of nail color (HP:0100643)2.92463357
49Steatorrhea (HP:0002570)2.92010889
50Abnormality of the axillary hair (HP:0100134)2.91623995
51Abnormality of secondary sexual hair (HP:0009888)2.91623995
52Onycholysis (HP:0001806)2.88630075
53Alopecia of scalp (HP:0002293)2.86883744
54Abnormality of nucleobase metabolism (HP:0010932)2.86399342
55Gout (HP:0001997)2.81566313
56Palmoplantar hyperkeratosis (HP:0000972)2.78753116
57Abnormality of purine metabolism (HP:0004352)2.70450298
58Delayed CNS myelination (HP:0002188)2.67065118
59Palmar hyperkeratosis (HP:0010765)2.66719705
60Proximal tubulopathy (HP:0000114)2.66058258
61Right ventricular cardiomyopathy (HP:0011663)2.65890177
62Hypotrichosis (HP:0001006)2.64744823
63Abnormality of serum amino acid levels (HP:0003112)2.64407116
64Metabolic acidosis (HP:0001942)2.59624243
65Abnormality of endocrine pancreas physiology (HP:0012093)2.57557454
66Abnormality of the pancreatic islet cells (HP:0006476)2.57557454
67Hepatocellular carcinoma (HP:0001402)2.54816465
68Milia (HP:0001056)2.53428700
69Vascular calcification (HP:0004934)2.50458377
70Pancreatic islet-cell hyperplasia (HP:0004510)2.50437531
71Abnormality of vitamin metabolism (HP:0100508)2.48289149
72Hypoplastic labia majora (HP:0000059)2.46661713
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.44962897
74Dicarboxylic aciduria (HP:0003215)2.44962897
75Myocardial infarction (HP:0001658)2.44934315
76Generalized aminoaciduria (HP:0002909)2.43709346
77Abnormality of the nasal septum (HP:0000419)2.42520755
78Acanthocytosis (HP:0001927)2.42206870
79Lethargy (HP:0001254)2.41611474
80Osteomalacia (HP:0002749)2.40811746
81Rickets (HP:0002748)2.38377752
82Lip pit (HP:0100267)2.37560424
83Mitral stenosis (HP:0001718)2.36741129
84Sensorimotor neuropathy (HP:0007141)2.32548939
85Enlarged kidneys (HP:0000105)2.31717174
86Pancreatitis (HP:0001733)2.29452736
87Hydroxyprolinuria (HP:0003080)2.26521242
88Abnormality of proline metabolism (HP:0010907)2.26521242
89Spontaneous abortion (HP:0005268)2.26306322
90Irritability (HP:0000737)2.25004756
91Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24349526
92Hypochromic microcytic anemia (HP:0004840)2.22817963
93Renal cortical cysts (HP:0000803)2.20821932
94Abnormal hair laboratory examination (HP:0003328)2.19237425
95Generalized hypopigmentation of hair (HP:0011358)2.18555236
96Cerebral edema (HP:0002181)2.18530685
97Cardiovascular calcification (HP:0011915)2.17192717
98Hypothermia (HP:0002045)2.15794446
99Abnormality of the labia majora (HP:0012881)2.14639769
100Systemic lupus erythematosus (HP:0002725)2.13455100
101Glomerulonephritis (HP:0000099)2.13003203
102Fragile nails (HP:0001808)2.11772385
103Pigmentary retinal degeneration (HP:0001146)2.07702329
104Glycosuria (HP:0003076)2.06600956
105Abnormality of urine glucose concentration (HP:0011016)2.06600956
106Menorrhagia (HP:0000132)2.06567537
107Woolly hair (HP:0002224)2.03841778
108Amelogenesis imperfecta (HP:0000705)2.03300387
109Abnormal gallbladder morphology (HP:0012437)2.03179408
110Retinal atrophy (HP:0001105)2.01772783
111Esophageal varix (HP:0002040)2.00864036
112Chronic hepatic failure (HP:0100626)2.00024085
113Neonatal onset (HP:0003623)1.98208789
114Brushfield spots (HP:0001088)1.98023592
115Pili torti (HP:0003777)1.96915289
116Malnutrition (HP:0004395)1.96290932
117Dry hair (HP:0011359)1.96157513
118Abnormality of calcium-phosphate metabolism (HP:0100530)1.95312675
119Vomiting (HP:0002013)1.94994176
120Congenital ichthyosiform erythroderma (HP:0007431)1.94493054
121Thick nail (HP:0001805)1.92869564
122Abnormality of the vitamin B12 metabolism (HP:0004341)1.92572442
123Hypophosphatemia (HP:0002148)1.91302884
124Abnormal enzyme/coenzyme activity (HP:0012379)1.90915549
125Recurrent gram-negative bacterial infections (HP:0005420)1.90481414
126Atrophic scars (HP:0001075)1.89851305
127Hypoplasia of dental enamel (HP:0006297)1.87311565
128Alkalosis (HP:0001948)1.87148105
129Abnormality of vitamin B metabolism (HP:0004340)1.86598986
130Opisthotonus (HP:0002179)1.85133657
131Corneal erosion (HP:0200020)1.84473750
132Dehydration (HP:0001944)1.83991118
133Hypophosphatemic rickets (HP:0004912)1.83227560
134Gingival bleeding (HP:0000225)1.83225458
135Bifid scrotum (HP:0000048)1.82251719
136Hyperphosphaturia (HP:0003109)1.76491053
137Elevated alkaline phosphatase (HP:0003155)1.74604764
138Elevated hepatic transaminases (HP:0002910)1.74066727
139Amyloidosis (HP:0011034)1.73923754
140Spastic diplegia (HP:0001264)1.73651929
141Abnormality of alkaline phosphatase activity (HP:0004379)1.71410639
142Erythroderma (HP:0001019)1.70932354
143Widely patent fontanelles and sutures (HP:0004492)1.69531307
144Blue irides (HP:0000635)1.67981968
145Absent eyelashes (HP:0000561)1.67281966
146Hyperactive renin-angiotensin system (HP:0000841)1.66301336
147Joint swelling (HP:0001386)1.65529646
148Abnormality of renal excretion (HP:0011036)1.64633551
149Megaloblastic anemia (HP:0001889)1.57339097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.72749541
2BCKDK4.90555135
3TAOK34.88805119
4INSRR4.75224127
5WNK34.40771497
6FRK3.94114773
7ERN13.25005010
8SIK13.16055205
9MUSK3.11327355
10FGFR42.83249041
11OXSR12.59014331
12ERBB42.48524990
13WNK42.41416316
14STK392.37593383
15MYLK2.33792268
16MAP3K92.27064686
17MST1R2.22857308
18STK242.02544374
19NLK1.93998155
20MAP3K121.92227263
21FLT31.62611981
22TGFBR11.60021600
23PTK61.58336842
24TRPM71.49538430
25LATS11.41532105
26STK38L1.36503900
27MAP3K61.32545104
28BMPR1B1.30527080
29BRSK21.29329699
30MST41.23267162
31NUAK11.20082728
32NTRK31.19399794
33EPHA21.18162265
34MAPK111.16064127
35MAP3K21.16006429
36EPHA31.15933227
37IRAK31.15236275
38TAF11.14202634
39DYRK1B1.04398017
40STK31.02423370
41EEF2K1.01112269
42MAP3K30.96446136
43MAP2K40.95866038
44TRIM280.93875942
45PRKAA20.92931052
46MAP3K40.92768416
47DAPK20.89942808
48MAP3K10.89858766
49PRKD30.89399124
50MET0.88831145
51EIF2AK30.88399738
52JAK20.87620280
53NEK60.85524242
54FGFR20.85197641
55PAK30.83007220
56NEK90.81916026
57TYK20.81285591
58PTK20.80132540
59TNIK0.79192324
60FGFR10.77642803
61TRIB30.77322818
62CASK0.77235273
63ERBB30.76749895
64LMTK20.75657790
65BRD40.73952627
66STK380.73474247
67IRAK10.73117536
68HIPK20.72853771
69MAPKAPK50.71939530
70MAP3K70.71112480
71PRKAA10.68854994
72GRK10.68754648
73PLK40.67324359
74FER0.67288320
75GSK3A0.66721726
76CSK0.63820683
77JAK10.63574422
78ERBB20.63055850
79RIPK10.62458844
80ACVR1B0.59860555
81PDK20.59661799
82TGFBR20.57560612
83ADRBK10.57336800
84UHMK10.57003006
85MAP2K60.56642385
86PRKACG0.52866892
87EPHB10.52849937
88RET0.52640588
89MAP3K130.52456471
90CAMK1D0.51661565
91PKN20.50446366
92MAP3K140.49504230
93CDK60.49340945
94MAP2K20.48076441
95SGK20.47724268
96MAP2K70.47039855
97ABL20.45786910
98LATS20.45320395
99PRKCZ0.45139123
100AKT30.44793331
101MELK0.44607602
102PINK10.44105087
103GRK70.43207837
104MAP2K10.42395208
105CDK30.41864271
106CAMK1G0.41550265
107CSNK1G20.40732817
108WNK10.40187298
109SGK30.39999478
110CDK90.39479356
111CAMK2G0.38605559
112MAP3K110.38367983
113MAPK70.38178698
114ADRBK20.37578661
115IGF1R0.37501201
116SGK2230.36257670
117SGK4940.36257670
118CSNK1D0.36120946
119ROCK10.36050448
120MAPK40.35913312
121PIK3CA0.34560752
122MTOR0.34372567
123PRKCQ0.33840846
124PBK0.32491162
125BCR0.32475251
126DMPK0.31383754
127TIE10.30145821
128DDR20.29983130
129PRKCG0.29531792
130PDGFRA0.29406558
131RPS6KB20.29069735
132MARK10.28923389
133KDR0.28425403
134PDGFRB0.28339301
135PRKCA0.27696652
136PRKCH0.27289720
137MAP2K30.27094257
138PRKCE0.26428401
139PDPK10.23873399
140KSR20.23863093
141PRKACA0.23511037
142MAPKAPK30.21457632
143PRKD10.20410765
144PRKG20.19561576
145FGFR30.19160932
146NTRK10.18687432
147CHUK0.18580904
148RPS6KB10.17246156
149CSNK1G10.17206370
150ITK0.15935688

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30165864
2Nitrogen metabolism_Homo sapiens_hsa009103.45152419
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24674491
4Arginine biosynthesis_Homo sapiens_hsa002202.75908642
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71556108
6Tryptophan metabolism_Homo sapiens_hsa003802.70460766
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.70329508
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57654810
9Complement and coagulation cascades_Homo sapiens_hsa046102.56402112
10Fatty acid degradation_Homo sapiens_hsa000712.53735050
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52851709
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37852725
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.28002748
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22770044
15Butanoate metabolism_Homo sapiens_hsa006502.19808472
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16531622
17Peroxisome_Homo sapiens_hsa041462.13477048
18Propanoate metabolism_Homo sapiens_hsa006402.06482099
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.99084826
20Histidine metabolism_Homo sapiens_hsa003401.98804575
21Chemical carcinogenesis_Homo sapiens_hsa052041.89531936
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87277765
23Fatty acid metabolism_Homo sapiens_hsa012121.83839180
24beta-Alanine metabolism_Homo sapiens_hsa004101.80510300
25PPAR signaling pathway_Homo sapiens_hsa033201.76623271
26Sulfur metabolism_Homo sapiens_hsa009201.70931882
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.69084753
28Retinol metabolism_Homo sapiens_hsa008301.65322839
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62551498
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58753894
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55127547
32Selenocompound metabolism_Homo sapiens_hsa004501.54850715
33Phenylalanine metabolism_Homo sapiens_hsa003601.53914312
34ABC transporters_Homo sapiens_hsa020101.52997459
35Caffeine metabolism_Homo sapiens_hsa002321.52532385
36Staphylococcus aureus infection_Homo sapiens_hsa051501.50647975
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46467445
38Folate biosynthesis_Homo sapiens_hsa007901.46100089
39Fatty acid elongation_Homo sapiens_hsa000621.46024550
40Bile secretion_Homo sapiens_hsa049761.43257941
41Tyrosine metabolism_Homo sapiens_hsa003501.42499194
42Fat digestion and absorption_Homo sapiens_hsa049751.40105543
43Starch and sucrose metabolism_Homo sapiens_hsa005001.38430820
44Steroid biosynthesis_Homo sapiens_hsa001001.35877134
45Pyruvate metabolism_Homo sapiens_hsa006201.30177450
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03119976
47Vitamin digestion and absorption_Homo sapiens_hsa049770.97263508
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.96527150
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96370725
50Sphingolipid metabolism_Homo sapiens_hsa006000.89771746
51Arginine and proline metabolism_Homo sapiens_hsa003300.89248396
52Carbon metabolism_Homo sapiens_hsa012000.89109069
53Lysine degradation_Homo sapiens_hsa003100.87067892
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.86498984
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82428260
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82005851
57Biosynthesis of amino acids_Homo sapiens_hsa012300.81323231
58Mineral absorption_Homo sapiens_hsa049780.73461442
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72732026
60Sulfur relay system_Homo sapiens_hsa041220.66865022
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66208320
62Vitamin B6 metabolism_Homo sapiens_hsa007500.65806465
63Glutathione metabolism_Homo sapiens_hsa004800.65286420
64Glycerolipid metabolism_Homo sapiens_hsa005610.63361091
65One carbon pool by folate_Homo sapiens_hsa006700.62649954
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58943558
67ECM-receptor interaction_Homo sapiens_hsa045120.56833264
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53559401
69Linoleic acid metabolism_Homo sapiens_hsa005910.49757480
70* Metabolic pathways_Homo sapiens_hsa011000.48184086
71Protein export_Homo sapiens_hsa030600.45780200
72Fatty acid biosynthesis_Homo sapiens_hsa000610.38969765
73Prion diseases_Homo sapiens_hsa050200.37240763
74Serotonergic synapse_Homo sapiens_hsa047260.35592852
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.35303348
76Pentose phosphate pathway_Homo sapiens_hsa000300.34273764
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31794265
78Glucagon signaling pathway_Homo sapiens_hsa049220.31435767
79Ovarian steroidogenesis_Homo sapiens_hsa049130.30278008
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30156947
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26187097
82Insulin resistance_Homo sapiens_hsa049310.24831483
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24066164
84Galactose metabolism_Homo sapiens_hsa000520.23426274
85Dorso-ventral axis formation_Homo sapiens_hsa043200.23097801
86Phototransduction_Homo sapiens_hsa047440.21987101
87Collecting duct acid secretion_Homo sapiens_hsa049660.20752690
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.19014798
89Fructose and mannose metabolism_Homo sapiens_hsa000510.18260039
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.16993352
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.16025256
92Gastric acid secretion_Homo sapiens_hsa049710.13440151
93Tight junction_Homo sapiens_hsa045300.11923488
94Amoebiasis_Homo sapiens_hsa051460.11444413
95Regulation of autophagy_Homo sapiens_hsa041400.11315516
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.10942417
97Insulin secretion_Homo sapiens_hsa049110.09487926
98Protein digestion and absorption_Homo sapiens_hsa049740.08894320
99Other glycan degradation_Homo sapiens_hsa005110.08570780
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07817488
101Arachidonic acid metabolism_Homo sapiens_hsa005900.07756288
102Renin secretion_Homo sapiens_hsa049240.06269265
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.06193543
104Focal adhesion_Homo sapiens_hsa045100.05258054
105Adherens junction_Homo sapiens_hsa045200.04579227
106Salivary secretion_Homo sapiens_hsa049700.04554912
107AMPK signaling pathway_Homo sapiens_hsa041520.04180611
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04113406
109Thyroid hormone synthesis_Homo sapiens_hsa049180.03079826
110Lysosome_Homo sapiens_hsa04142-0.0559450
111Insulin signaling pathway_Homo sapiens_hsa04910-0.0494199
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0488927
113Circadian rhythm_Homo sapiens_hsa04710-0.0344439
114Ether lipid metabolism_Homo sapiens_hsa00565-0.0335736
115Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0198883
116Type II diabetes mellitus_Homo sapiens_hsa04930-0.0178807
117Pancreatic secretion_Homo sapiens_hsa04972-0.0168003
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0139226

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »