PIK3C3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of mast cell activation (GO:0033004)4.48754067
2synaptic vesicle docking involved in exocytosis (GO:0016081)4.18103401
3protein polyglutamylation (GO:0018095)4.07808170
4artery development (GO:0060840)3.93733819
5behavioral response to nicotine (GO:0035095)3.92388182
6monoubiquitinated protein deubiquitination (GO:0035520)3.87659503
7synaptic vesicle exocytosis (GO:0016079)3.87457238
8establishment of protein localization to Golgi (GO:0072600)3.86078177
9negative regulation of cell killing (GO:0031342)3.76884563
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.76884563
11regulation of synaptic vesicle exocytosis (GO:2000300)3.69523233
12negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.62081473
13regulation of B cell receptor signaling pathway (GO:0050855)3.57947192
14vesicle docking involved in exocytosis (GO:0006904)3.54245674
15negative regulation of leukocyte chemotaxis (GO:0002689)3.51648755
16gamma-aminobutyric acid transport (GO:0015812)3.49443242
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.49138454
18fucose catabolic process (GO:0019317)3.46427212
19L-fucose metabolic process (GO:0042354)3.46427212
20L-fucose catabolic process (GO:0042355)3.46427212
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.44371008
22detection of light stimulus involved in visual perception (GO:0050908)3.43655487
23detection of light stimulus involved in sensory perception (GO:0050962)3.43655487
24reflex (GO:0060004)3.38843140
25neuronal action potential propagation (GO:0019227)3.36450129
26positive regulation of B cell differentiation (GO:0045579)3.33053350
27mast cell activation involved in immune response (GO:0002279)3.31539383
28mast cell degranulation (GO:0043303)3.31539383
29protein targeting to Golgi (GO:0000042)3.29503692
30glutamate secretion (GO:0014047)3.27126193
31regulation of synaptic vesicle transport (GO:1902803)3.24289116
32cerebral cortex radially oriented cell migration (GO:0021799)3.24226640
33pyrimidine nucleobase catabolic process (GO:0006208)3.23128261
34negative regulation of dendrite morphogenesis (GO:0050774)3.22983913
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.22442629
36sulfation (GO:0051923)3.21564254
37cellular response to sterol (GO:0036315)3.17681726
38neural tube formation (GO:0001841)3.10542351
39retrograde transport, vesicle recycling within Golgi (GO:0000301)3.08622967
40protein localization to Golgi apparatus (GO:0034067)3.07702761
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.07268963
42primary amino compound metabolic process (GO:1901160)3.03268334
43B cell receptor signaling pathway (GO:0050853)3.02648562
44sequestering of actin monomers (GO:0042989)3.01395184
45adaptation of signaling pathway (GO:0023058)2.97342203
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97287181
47cerebellar granule cell differentiation (GO:0021707)2.96965754
48vesicle docking (GO:0048278)2.96125708
49axoneme assembly (GO:0035082)2.94395713
50regulation of neurotransmitter uptake (GO:0051580)2.93765060
51synaptic vesicle maturation (GO:0016188)2.92230266
52response to misfolded protein (GO:0051788)2.92035832
53proline transport (GO:0015824)2.91333891
54epithelial cilium movement (GO:0003351)2.87711124
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.85617959
56regulation of pigment cell differentiation (GO:0050932)2.85231889
57lysosome localization (GO:0032418)2.85062932
58cilium or flagellum-dependent cell motility (GO:0001539)2.84751254
59antigen processing and presentation via MHC class Ib (GO:0002475)2.84091932
60positive regulation of developmental pigmentation (GO:0048087)2.84021417
61barbed-end actin filament capping (GO:0051016)2.83787841
62glycosphingolipid biosynthetic process (GO:0006688)2.83278062
63negative regulation of dendrite development (GO:2000171)2.82943288
64indolalkylamine metabolic process (GO:0006586)2.81153203
65positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79587093
66gamma-aminobutyric acid signaling pathway (GO:0007214)2.79285448
67negative regulation of sodium ion transport (GO:0010766)2.78803578
68cerebellar Purkinje cell differentiation (GO:0021702)2.78149291
69positive regulation of gamma-delta T cell activation (GO:0046645)2.77611339
70transferrin transport (GO:0033572)2.77477646
71negative regulation of exocytosis (GO:0045920)2.77168463
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.74220427
73neuronal action potential (GO:0019228)2.73583633
74behavioral response to ethanol (GO:0048149)2.72923887
75positive regulation of macroautophagy (GO:0016239)2.72530113
76platelet dense granule organization (GO:0060155)2.72413616
77negative regulation of systemic arterial blood pressure (GO:0003085)2.71857281
78mast cell activation (GO:0045576)2.70470825
79photoreceptor cell maintenance (GO:0045494)2.69048142
80membrane depolarization during action potential (GO:0086010)2.68824174
81prenylation (GO:0097354)2.68214564
82protein prenylation (GO:0018342)2.68214564
83protein localization to synapse (GO:0035418)2.67761840
84histamine secretion (GO:0001821)2.67239518
85neuron-neuron synaptic transmission (GO:0007270)2.67097876
86G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66912549
87indole-containing compound catabolic process (GO:0042436)2.65459330
88indolalkylamine catabolic process (GO:0046218)2.65459330
89tryptophan catabolic process (GO:0006569)2.65459330
90nucleobase catabolic process (GO:0046113)2.64226103
91transmission of nerve impulse (GO:0019226)2.63883557
92positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.63726333
93interkinetic nuclear migration (GO:0022027)2.62214358
94regulation of glutamate receptor signaling pathway (GO:1900449)2.62025302
95protein K11-linked deubiquitination (GO:0035871)2.60869830
96mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.60864681
97positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.60864681
98cilium movement (GO:0003341)2.60278129
99serotonin metabolic process (GO:0042428)2.59868157
100indole-containing compound metabolic process (GO:0042430)2.59801439
101regulation of establishment of cell polarity (GO:2000114)2.59754924
102retinal cone cell development (GO:0046549)2.59573004
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59487837
104inner ear receptor stereocilium organization (GO:0060122)2.58136810
105regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.58007123
106regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.58007123
107ATP hydrolysis coupled proton transport (GO:0015991)2.57973421
108energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.57973421
109synaptic transmission, glutamatergic (GO:0035249)2.57849935
110glucocorticoid receptor signaling pathway (GO:0042921)2.57039030
111positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56666848
112negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.53625474
113negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52520862
114positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.52134921
115negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50460078
116RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50248767
117actin filament capping (GO:0051693)2.50226588
118regulation of B cell differentiation (GO:0045577)2.50210008
119cAMP catabolic process (GO:0006198)2.48286214
120rhodopsin mediated signaling pathway (GO:0016056)2.48164731
121protein localization to cilium (GO:0061512)2.47025471
122negative regulation of neurotransmitter transport (GO:0051589)2.46837342
123ferric iron transport (GO:0015682)2.46740679
124trivalent inorganic cation transport (GO:0072512)2.46740679
125regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46692136
126regulation of Rap GTPase activity (GO:0032317)2.46626853
127cytokine production involved in immune response (GO:0002367)2.46619645
128response to pheromone (GO:0019236)2.45082312
129cellular response to cholesterol (GO:0071397)2.44821099
130cellular biogenic amine catabolic process (GO:0042402)2.43138554
131amine catabolic process (GO:0009310)2.43138554
132neurotransmitter secretion (GO:0007269)2.42626743
133positive regulation of cardiac muscle cell differentiation (GO:2000727)2.42224863
134auditory behavior (GO:0031223)2.42076840
135response to sterol (GO:0036314)2.41978289
136negative regulation of translation, ncRNA-mediated (GO:0040033)2.41787383
137regulation of translation, ncRNA-mediated (GO:0045974)2.41787383
138negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.41787383
139ribonucleoprotein complex disassembly (GO:0032988)2.41662791
140presynaptic membrane organization (GO:0097090)2.41652039
141central nervous system neuron axonogenesis (GO:0021955)2.41430916
142positive regulation of histone H3-K4 methylation (GO:0051571)2.40086319
143regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.38818941
144peristalsis (GO:0030432)2.38572794
145cilium organization (GO:0044782)2.38181149
146regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37851134
147lipid translocation (GO:0034204)2.37805510
148phospholipid translocation (GO:0045332)2.37805510
149regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.37734606
150regulation of action potential (GO:0098900)2.37602824
151negative regulation of microtubule polymerization (GO:0031115)2.37419271
152oxaloacetate metabolic process (GO:0006107)2.36979108
153tryptophan metabolic process (GO:0006568)2.36433500
154protein K48-linked deubiquitination (GO:0071108)2.35783412
155activated T cell proliferation (GO:0050798)2.34270195
156retinal ganglion cell axon guidance (GO:0031290)2.33999568
157cyclic nucleotide catabolic process (GO:0009214)2.32849635
158misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.32697915
159vocalization behavior (GO:0071625)2.30946841
160autophagic vacuole fusion (GO:0000046)2.28944369
161mitotic chromosome condensation (GO:0007076)2.28755021
162vesicle transport along microtubule (GO:0047496)2.28300785
163presynaptic membrane assembly (GO:0097105)2.27427660
164neuron cell-cell adhesion (GO:0007158)2.27279732
165phagosome maturation (GO:0090382)2.26887488
166positive regulation of Rap GTPase activity (GO:0032854)2.25647806
167startle response (GO:0001964)2.24727291
168negative thymic T cell selection (GO:0045060)2.24265365
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.23585873
170somatic diversification of immune receptors via somatic mutation (GO:0002566)2.23585873
171negative regulation of actin filament depolymerization (GO:0030835)2.23372003
172negative T cell selection (GO:0043383)2.22684050
173Rac protein signal transduction (GO:0016601)2.22673852
174NADH metabolic process (GO:0006734)2.21211623
175regulation of postsynaptic membrane potential (GO:0060078)2.20594544
176positive regulation of membrane potential (GO:0045838)2.20195362
177membrane docking (GO:0022406)2.18901470
178adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.18255719
179synaptic vesicle transport (GO:0048489)2.18192757
180establishment of synaptic vesicle localization (GO:0097480)2.18192757
181positive regulation of megakaryocyte differentiation (GO:0045654)2.17217902
182phosphatidylinositol dephosphorylation (GO:0046856)2.16826916
183purine nucleobase biosynthetic process (GO:0009113)2.16459263
184activation of protein kinase A activity (GO:0034199)2.16394289
185regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.16225138
186adult walking behavior (GO:0007628)2.16140154
187mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.15855206
188mitochondrial genome maintenance (GO:0000002)2.15017629
189regulation of collateral sprouting (GO:0048670)2.14762778
190negative regulation of meiosis (GO:0045835)2.14528750
191negative regulation of protein oligomerization (GO:0032460)2.13159076
192detection of temperature stimulus (GO:0016048)2.13032230
193organelle transport along microtubule (GO:0072384)2.12941619
194long-chain fatty acid biosynthetic process (GO:0042759)2.12850558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.49834772
2EZH2_22144423_ChIP-Seq_EOC_Human3.13740038
3* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.90695416
4IGF1R_20145208_ChIP-Seq_DFB_Human2.85212700
5ZNF274_21170338_ChIP-Seq_K562_Hela2.73876152
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.70541322
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.70474187
8TAF15_26573619_Chip-Seq_HEK293_Human2.58171979
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55672328
10VDR_22108803_ChIP-Seq_LS180_Human2.53614851
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44470858
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.41914450
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.36521124
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24083861
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.21666699
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21319628
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19762053
18* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17505150
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13146819
20* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13059567
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08244847
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.07966096
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.07289620
24* P300_19829295_ChIP-Seq_ESCs_Human2.06695066
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05011588
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01408025
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.99706443
28CIITA_25753668_ChIP-Seq_RAJI_Human1.94074232
29SMAD4_21799915_ChIP-Seq_A2780_Human1.92840266
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89224567
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88601957
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86679237
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85856265
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85048942
35* STAT3_23295773_ChIP-Seq_U87_Human1.83794341
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82579747
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81576317
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81316198
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79997219
40ER_23166858_ChIP-Seq_MCF-7_Human1.79276954
41GBX2_23144817_ChIP-Seq_PC3_Human1.76629640
42VDR_23849224_ChIP-Seq_CD4+_Human1.75281967
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75073621
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.74120878
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73349195
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73100466
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70727954
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69763367
49AR_21572438_ChIP-Seq_LNCaP_Human1.69546054
50* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67867428
51TCF4_23295773_ChIP-Seq_U87_Human1.66601030
52* MYB_26560356_Chip-Seq_TH2_Human1.65438677
53TP53_16413492_ChIP-PET_HCT116_Human1.65195868
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64273280
55BCAT_22108803_ChIP-Seq_LS180_Human1.63946035
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63481551
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.63022247
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62577542
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60572584
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59706240
61GATA1_22025678_ChIP-Seq_K562_Human1.59559776
62SCL_19346495_ChIP-Seq_HPC-7_Human1.58098858
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56246750
64MYC_22102868_ChIP-Seq_BL_Human1.55938137
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.54704907
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.54109007
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54081130
68* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53632712
69* AR_25329375_ChIP-Seq_VCAP_Human1.52800327
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52754862
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51266264
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51046320
73* EST1_17652178_ChIP-ChIP_JURKAT_Human1.50706205
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48250966
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48250966
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47664472
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.46554302
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46239970
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.45753120
80RUNX_20019798_ChIP-Seq_JUKART_Human1.45687327
81TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44880110
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44064034
83CBP_20019798_ChIP-Seq_JUKART_Human1.44064034
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43975764
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43196175
86* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42111605
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41455854
88* REST_21632747_ChIP-Seq_MESCs_Mouse1.41141156
89* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40703651
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39161804
91SMAD_19615063_ChIP-ChIP_OVARY_Human1.38952423
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38719107
93NANOG_18555785_Chip-Seq_ESCs_Mouse1.38601588
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37968477
95FOXP3_21729870_ChIP-Seq_TREG_Human1.37906277
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37828246
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.36954761
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36477331
99REST_18959480_ChIP-ChIP_MESCs_Mouse1.35123529
100* PRDM14_20953172_ChIP-Seq_ESCs_Human1.34470092
101* ETS1_20019798_ChIP-Seq_JURKAT_Human1.34244128
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.33127319
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32579797
104KDM5A_27292631_Chip-Seq_BREAST_Human1.32385186
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31125820
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31015412
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30988114
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29161796
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.27157854
110EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27146172
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26918025
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26648157
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26349291
114* ELK1_19687146_ChIP-ChIP_HELA_Human1.25719769
115RUNX2_22187159_ChIP-Seq_PCA_Human1.25427541
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25403402
117TCF4_22108803_ChIP-Seq_LS180_Human1.24720383
118* SOX2_19829295_ChIP-Seq_ESCs_Human1.24653797
119* NANOG_19829295_ChIP-Seq_ESCs_Human1.24653797
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23711734
121SPI1_23547873_ChIP-Seq_NB4_Human1.22974460
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22534635
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.22291210
124EWS_26573619_Chip-Seq_HEK293_Human1.22204437
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21821715
126P53_22387025_ChIP-Seq_ESCs_Mouse1.21326386
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.20930227
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.20735475
129MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17779128
130TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17727854
131* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17171333
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16267899
133* SOX2_21211035_ChIP-Seq_LN229_Gbm1.16150402
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15985007
135OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15646522
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14770854
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14767379
138* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14212750
139GATA3_26560356_Chip-Seq_TH2_Human1.13930016
140SALL1_21062744_ChIP-ChIP_HESCs_Human1.13802576
141CMYC_18555785_Chip-Seq_ESCs_Mouse1.12641812
142GABP_19822575_ChIP-Seq_HepG2_Human1.12094482
143ARNT_22903824_ChIP-Seq_MCF-7_Human1.11634775
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11406033
145NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11406033
146SPI1_23127762_ChIP-Seq_K562_Human1.11375955
147EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09675030
148MYB_26560356_Chip-Seq_TH1_Human1.08216379
149NOTCH1_21737748_ChIP-Seq_TLL_Human1.07508821
150IRF1_19129219_ChIP-ChIP_H3396_Human1.07402068
151TAL1_26923725_Chip-Seq_HPCs_Mouse1.06678633
152EGR1_19374776_ChIP-ChIP_THP-1_Human1.06536172
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06455558
154* JUN_21703547_ChIP-Seq_K562_Human1.06093030
155CDX2_22108803_ChIP-Seq_LS180_Human1.06036297
156* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05773395
157NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05674889
158TP53_22573176_ChIP-Seq_HFKS_Human1.05312874
159SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05216253
160TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03981784
161CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03784302
162BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03421358
163* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02868994
164STAT3_18555785_Chip-Seq_ESCs_Mouse1.02427254
165TFEB_21752829_ChIP-Seq_HELA_Human1.02314344
166* RNF2_27304074_Chip-Seq_NSC_Mouse1.02174119
167GATA3_27048872_Chip-Seq_THYMUS_Human1.01687250
168* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01525971
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01351410
170RUNX1_22412390_ChIP-Seq_EML_Mouse0.99826674
171* KDM2B_26808549_Chip-Seq_REH_Human0.99497224
172GATA3_26560356_Chip-Seq_TH1_Human0.99311079
173E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99064171
174HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97480332
175IRF8_22096565_ChIP-ChIP_GC-B_Human0.96421164
176CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96060594
177STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94549423
178PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94172205
179STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93943321
180GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92966962
181GATA1_26923725_Chip-Seq_HPCs_Mouse0.92689899
182ETS1_22383799_ChIP-Seq_G1ME_Mouse0.91322688
183FUS_26573619_Chip-Seq_HEK293_Human0.89366768
184SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89242959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.13385064
2MP0004859_abnormal_synaptic_plasticity4.00181371
3MP0002638_abnormal_pupillary_reflex3.67359711
4MP0008877_abnormal_DNA_methylation3.31610021
5MP0004270_analgesia3.20842897
6MP0003011_delayed_dark_adaptation3.06866775
7MP0008260_abnormal_autophagy2.72465770
8MP0003635_abnormal_synaptic_transmissio2.70432701
9MP0005551_abnormal_eye_electrophysiolog2.58962501
10MP0001968_abnormal_touch/_nociception2.50203517
11MP0002735_abnormal_chemical_nociception2.44257360
12MP0008004_abnormal_stomach_pH2.42178327
13MP0002064_seizures2.34186734
14MP0000427_abnormal_hair_cycle2.31622856
15MP0002102_abnormal_ear_morphology2.26788739
16MP0003195_calcinosis2.23813334
17MP0000383_abnormal_hair_follicle2.21047835
18MP0000569_abnormal_digit_pigmentation2.20038774
19MP0002063_abnormal_learning/memory/cond2.19291463
20MP0009046_muscle_twitch2.18011230
21MP0002272_abnormal_nervous_system2.13824432
22MP0002736_abnormal_nociception_after2.13658216
23MP0009745_abnormal_behavioral_response2.08148699
24MP0006072_abnormal_retinal_apoptosis2.07731404
25MP0003787_abnormal_imprinting2.06456603
26MP0005253_abnormal_eye_physiology2.04666804
27MP0002396_abnormal_hematopoietic_system2.00964961
28MP0004142_abnormal_muscle_tone1.93805348
29MP0005310_abnormal_salivary_gland1.86546313
30MP0002572_abnormal_emotion/affect_behav1.85991343
31MP0003122_maternal_imprinting1.83971850
32MP0005671_abnormal_response_to1.78191646
33MP0002734_abnormal_mechanical_nocicepti1.74869716
34MP0002733_abnormal_thermal_nociception1.70178228
35MP0005083_abnormal_biliary_tract1.66835184
36MP0005646_abnormal_pituitary_gland1.66443784
37MP0001835_abnormal_antigen_presentation1.65242138
38MP0003172_abnormal_lysosome_physiology1.63211295
39MP0004885_abnormal_endolymph1.62482517
40MP0003646_muscle_fatigue1.62402945
41MP0001984_abnormal_olfaction1.61695907
42MP0002067_abnormal_sensory_capabilities1.61167508
43MP0003183_abnormal_peptide_metabolism1.56981980
44MP0003121_genomic_imprinting1.54518795
45MP0004145_abnormal_muscle_electrophysio1.48964861
46MP0005379_endocrine/exocrine_gland_phen1.47484467
47MP0001970_abnormal_pain_threshold1.46230635
48MP0008569_lethality_at_weaning1.46042363
49MP0008058_abnormal_DNA_repair1.43333984
50MP0005085_abnormal_gallbladder_physiolo1.42614091
51MP0004811_abnormal_neuron_physiology1.42461767
52MP0001486_abnormal_startle_reflex1.41867109
53MP0001485_abnormal_pinna_reflex1.36776911
54MP0003633_abnormal_nervous_system1.36599884
55MP0002837_dystrophic_cardiac_calcinosis1.36332603
56MP0002822_catalepsy1.35957813
57MP0010094_abnormal_chromosome_stability1.35691274
58MP0004742_abnormal_vestibular_system1.33582703
59MP0001440_abnormal_grooming_behavior1.33254302
60MP0008875_abnormal_xenobiotic_pharmacok1.32301480
61MP0000920_abnormal_myelination1.32111107
62MP0003890_abnormal_embryonic-extraembry1.30149157
63MP0000631_abnormal_neuroendocrine_gland1.28878961
64MP0002928_abnormal_bile_duct1.28830267
65MP0003631_nervous_system_phenotype1.28497450
66MP0003329_amyloid_beta_deposits1.27619689
67MP0005174_abnormal_tail_pigmentation1.26719722
68MP0002398_abnormal_bone_marrow1.26680020
69MP0002160_abnormal_reproductive_system1.25866634
70MP0005084_abnormal_gallbladder_morpholo1.24836585
71MP0002876_abnormal_thyroid_physiology1.22462693
72MP0005187_abnormal_penis_morphology1.20781643
73MP0001800_abnormal_humoral_immune1.20638536
74MP0005389_reproductive_system_phenotype1.19730181
75MP0002420_abnormal_adaptive_immunity1.14909409
76MP0001819_abnormal_immune_cell1.13894205
77MP0000604_amyloidosis1.10965449
78MP0001986_abnormal_taste_sensitivity1.10644999
79MP0003632_abnormal_nervous_system1.10324871
80MP0000465_gastrointestinal_hemorrhage1.08779869
81MP0000716_abnormal_immune_system1.06078280
82MP0000013_abnormal_adipose_tissue1.05210463
83MP0005645_abnormal_hypothalamus_physiol1.04886192
84MP0002723_abnormal_immune_serum1.04385617
85MP0002166_altered_tumor_susceptibility1.03607007
86MP0000703_abnormal_thymus_morphology1.03395783
87MP0004130_abnormal_muscle_cell1.02492430
88MP0003252_abnormal_bile_duct1.02341907
89MP0004924_abnormal_behavior1.02242453
90MP0005386_behavior/neurological_phenoty1.02242453
91MP0010234_abnormal_vibrissa_follicle1.01113458
92MP0002066_abnormal_motor_capabilities/c0.99842690
93MP0002184_abnormal_innervation0.99515032
94MP0005535_abnormal_body_temperature0.98963986
95MP0000647_abnormal_sebaceous_gland0.98769796
96MP0006292_abnormal_olfactory_placode0.97752284
97MP0003763_abnormal_thymus_physiology0.97478433
98MP0002229_neurodegeneration0.97341504
99MP0008057_abnormal_DNA_replication0.96936290
100MP0000778_abnormal_nervous_system0.95879908
101MP0008872_abnormal_physiological_respon0.95227315
102MP0005409_darkened_coat_color0.94901946
103MP0000689_abnormal_spleen_morphology0.94257247
104MP0000230_abnormal_systemic_arterial0.94148380
105MP0001905_abnormal_dopamine_level0.93735697
106MP0005195_abnormal_posterior_eye0.93418616
107MP0001919_abnormal_reproductive_system0.92726348
108MP0002452_abnormal_antigen_presenting0.92718818
109MP0005058_abnormal_lysosome_morphology0.92635504
110MP0004215_abnormal_myocardial_fiber0.91788844
111MP0004147_increased_porphyrin_level0.91183948
112MP0005075_abnormal_melanosome_morpholog0.91011677
113MP0002653_abnormal_ependyma_morphology0.90820554
114MP0001529_abnormal_vocalization0.90171998
115MP0002557_abnormal_social/conspecific_i0.89855641
116MP0001501_abnormal_sleep_pattern0.89146970
117MP0005397_hematopoietic_system_phenotyp0.88562043
118MP0001545_abnormal_hematopoietic_system0.88562043
119MP0002722_abnormal_immune_system0.88351935
120MP0002909_abnormal_adrenal_gland0.88337345
121MP0003077_abnormal_cell_cycle0.87936370
122MP0002752_abnormal_somatic_nervous0.87456742
123MP0003879_abnormal_hair_cell0.87092956
124MP0008995_early_reproductive_senescence0.86798188
125MP0002429_abnormal_blood_cell0.86074107
126MP0008874_decreased_physiological_sensi0.85373821
127MP0005000_abnormal_immune_tolerance0.85276359
128MP0000955_abnormal_spinal_cord0.85160874
129MP0004484_altered_response_of0.85024055
130MP0002095_abnormal_skin_pigmentation0.84601072
131MP0005387_immune_system_phenotype0.83755574
132MP0001790_abnormal_immune_system0.83755574
133MP0001730_embryonic_growth_arrest0.83459379
134MP0002751_abnormal_autonomic_nervous0.83277109
135MP0002693_abnormal_pancreas_physiology0.82100449
136MP0001502_abnormal_circadian_rhythm0.81898701
137MP0003866_abnormal_defecation0.81838621
138MP0006054_spinal_hemorrhage0.81682860
139MP0002009_preneoplasia0.81623725
140MP0002882_abnormal_neuron_morphology0.79806076
141MP0010386_abnormal_urinary_bladder0.79152451
142MP0003693_abnormal_embryo_hatching0.78904602
143MP0010678_abnormal_skin_adnexa0.78181054
144MP0004957_abnormal_blastocyst_morpholog0.78038673
145MP0005167_abnormal_blood-brain_barrier0.77538431
146MP0003943_abnormal_hepatobiliary_system0.77205886
147MP0000015_abnormal_ear_pigmentation0.76673656
148MP0004043_abnormal_pH_regulation0.76466638
149MP0005423_abnormal_somatic_nervous0.76215694
150MP0006276_abnormal_autonomic_nervous0.75613145
151MP0003950_abnormal_plasma_membrane0.75309017
152MP0003045_fibrosis0.74818245
153MP0005391_vision/eye_phenotype0.72860555
154MP0005171_absent_coat_pigmentation0.71689321
155MP0003937_abnormal_limbs/digits/tail_de0.71576929
156MP0001764_abnormal_homeostasis0.69092328

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.30623040
2Abnormal hair whorl (HP:0010721)4.65167058
3Epileptic encephalopathy (HP:0200134)4.03988686
4Genetic anticipation (HP:0003743)3.99602240
5Pancreatic cysts (HP:0001737)3.92519383
6True hermaphroditism (HP:0010459)3.85699418
7Pancreatic fibrosis (HP:0100732)3.62407606
8Abnormality of midbrain morphology (HP:0002418)3.50047073
9Molar tooth sign on MRI (HP:0002419)3.50047073
10Atonic seizures (HP:0010819)3.47845614
11Agnosia (HP:0010524)3.45829261
12Hyperventilation (HP:0002883)3.36813786
13Progressive cerebellar ataxia (HP:0002073)3.33529224
14Congenital stationary night blindness (HP:0007642)3.31983360
15Nephronophthisis (HP:0000090)3.27044935
16Chronic otitis media (HP:0000389)3.21734421
17Chronic hepatic failure (HP:0100626)3.21084637
18Abnormality of the renal cortex (HP:0011035)3.17108428
19Medial flaring of the eyebrow (HP:0010747)3.14688589
20Focal seizures (HP:0007359)3.14227575
21Febrile seizures (HP:0002373)3.12288599
22Abnormality of the renal medulla (HP:0100957)3.07419937
23Insidious onset (HP:0003587)3.02577402
24Termporal pattern (HP:0011008)3.02577402
25Absent speech (HP:0001344)2.92232048
26Abnormality of the corticospinal tract (HP:0002492)2.90499695
27Gait imbalance (HP:0002141)2.83094777
28Fair hair (HP:0002286)2.77602878
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.76514301
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.76514301
31Cerebellar dysplasia (HP:0007033)2.76190176
32Papilledema (HP:0001085)2.75005343
33Pheochromocytoma (HP:0002666)2.71184364
34Abnormality of the periventricular white matter (HP:0002518)2.71147860
35IgM deficiency (HP:0002850)2.70953259
36Visual hallucinations (HP:0002367)2.69439063
37Congenital primary aphakia (HP:0007707)2.67257060
38Impaired vibration sensation in the lower limbs (HP:0002166)2.66794593
39Spastic gait (HP:0002064)2.62181588
40Increased serum pyruvate (HP:0003542)2.62094623
41Abnormality of glycolysis (HP:0004366)2.62094623
42Absence seizures (HP:0002121)2.57126282
43Volvulus (HP:0002580)2.54040835
44Protruding tongue (HP:0010808)2.53814504
45Renal cortical cysts (HP:0000803)2.53068154
46Truncal ataxia (HP:0002078)2.49541651
47Cerebral hypomyelination (HP:0006808)2.49170202
48Dialeptic seizures (HP:0011146)2.48386878
49Nephrogenic diabetes insipidus (HP:0009806)2.43026614
50Widely spaced teeth (HP:0000687)2.41220553
51Attenuation of retinal blood vessels (HP:0007843)2.40865925
52Genital tract atresia (HP:0001827)2.40101851
53Urinary urgency (HP:0000012)2.37738223
54Myokymia (HP:0002411)2.37083996
55Stomach cancer (HP:0012126)2.36825566
56Generalized hypopigmentation of hair (HP:0011358)2.36666717
57Increased corneal curvature (HP:0100692)2.35168107
58Keratoconus (HP:0000563)2.35168107
59Inability to walk (HP:0002540)2.33121943
60Hypoplastic ischia (HP:0003175)2.32364061
61Vaginal atresia (HP:0000148)2.31965081
62Abolished electroretinogram (ERG) (HP:0000550)2.31722716
63Cystic liver disease (HP:0006706)2.31533592
64Progressive microcephaly (HP:0000253)2.29693793
65Dysautonomia (HP:0002459)2.27263409
66Urinary bladder sphincter dysfunction (HP:0002839)2.23870723
67Type II lissencephaly (HP:0007260)2.23348544
68Tubular atrophy (HP:0000092)2.22899478
69Amyotrophic lateral sclerosis (HP:0007354)2.21351085
70Action tremor (HP:0002345)2.21277065
71Supranuclear gaze palsy (HP:0000605)2.21198497
72Abnormality of the ischium (HP:0003174)2.21167325
73Furrowed tongue (HP:0000221)2.20912750
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.20818829
75CNS hypomyelination (HP:0003429)2.18770522
76Birth length less than 3rd percentile (HP:0003561)2.16777616
77Abnormality of the lower motor neuron (HP:0002366)2.14939654
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.14897453
79Poor coordination (HP:0002370)2.14840224
80Septate vagina (HP:0001153)2.14655535
81Broad-based gait (HP:0002136)2.14546116
82Increased cerebral lipofuscin (HP:0011813)2.14180860
83Neuroendocrine neoplasm (HP:0100634)2.12542377
84Recurrent viral infections (HP:0004429)2.11160531
85Elevated erythrocyte sedimentation rate (HP:0003565)2.11159050
86Short foot (HP:0001773)2.09492322
87Dyskinesia (HP:0100660)2.09070298
88Panhypogammaglobulinemia (HP:0003139)2.08023095
89Gaze-evoked nystagmus (HP:0000640)2.06826668
90Ankle clonus (HP:0011448)2.05943664
91Paraplegia (HP:0010550)2.05330368
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.04484151
93Absent/shortened dynein arms (HP:0200106)2.01731667
94Dynein arm defect of respiratory motile cilia (HP:0012255)2.01731667
95Small hand (HP:0200055)1.99916305
96Hypothermia (HP:0002045)1.97300421
97Autoamputation (HP:0001218)1.97237504
98B lymphocytopenia (HP:0010976)1.96598255
99Abnormality of B cell number (HP:0010975)1.96598255
100Male pseudohermaphroditism (HP:0000037)1.95932655
101Pachygyria (HP:0001302)1.95750482
102Poor eye contact (HP:0000817)1.94656575
103Abnormal rod and cone electroretinograms (HP:0008323)1.94193379
104Polydipsia (HP:0001959)1.93865242
105Abnormal drinking behavior (HP:0030082)1.93865242
106Stenosis of the external auditory canal (HP:0000402)1.93593374
107Retinal dysplasia (HP:0007973)1.92442449
108Cupped ear (HP:0000378)1.92213772
109Congenital hepatic fibrosis (HP:0002612)1.92077215
110Progressive inability to walk (HP:0002505)1.91775493
111Recurrent bacterial skin infections (HP:0005406)1.89837805
112Tubulointerstitial nephritis (HP:0001970)1.89834713
113Oligomenorrhea (HP:0000876)1.89608155
114Sensory axonal neuropathy (HP:0003390)1.88548854
115Generalized tonic-clonic seizures (HP:0002069)1.87967406
116Blue irides (HP:0000635)1.87309200
117Impaired smooth pursuit (HP:0007772)1.86947742
118Recurrent abscess formation (HP:0002722)1.86801458
119Anteriorly placed anus (HP:0001545)1.85367375
120Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84958694
121Large for gestational age (HP:0001520)1.84521173
122Abnormality of the pons (HP:0007361)1.84516233
123Spastic paraplegia (HP:0001258)1.83943145
124Postnatal microcephaly (HP:0005484)1.83923044
125Dysmetria (HP:0001310)1.83461013
126Submucous cleft hard palate (HP:0000176)1.83120614
127Resting tremor (HP:0002322)1.82964271
128Drooling (HP:0002307)1.82880678
129Excessive salivation (HP:0003781)1.82880678
130Epileptiform EEG discharges (HP:0011182)1.82634631
131Postaxial foot polydactyly (HP:0001830)1.81714789
132Abnormal social behavior (HP:0012433)1.81506384
133Impaired social interactions (HP:0000735)1.81506384
134Clitoromegaly (HP:0000057)1.80394031
135Thyroiditis (HP:0100646)1.79155457
136Upper motor neuron abnormality (HP:0002127)1.79101119
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.78643401
138Tubulointerstitial abnormality (HP:0001969)1.78208847
139Hypoplasia of the pons (HP:0012110)1.78153706
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77746548
141Abnormality of cochlea (HP:0000375)1.77016102
142Bulbous nose (HP:0000414)1.76535655
143Lissencephaly (HP:0001339)1.76289465
144Colon cancer (HP:0003003)1.75940249
145Hypoplasia of the thymus (HP:0000778)1.75898726
146Postaxial hand polydactyly (HP:0001162)1.74814629
147Hypoproteinemia (HP:0003075)1.74713714
148Abnormality of the astrocytes (HP:0100707)1.74622583
149Astrocytoma (HP:0009592)1.74622583
150Cortical dysplasia (HP:0002539)1.74012041
151Cellulitis (HP:0100658)1.73808606
152Palpebral edema (HP:0100540)1.73083276
153Cortical visual impairment (HP:0100704)1.73060522
154Impaired vibratory sensation (HP:0002495)1.72418395
155Conical tooth (HP:0000698)1.72228736
156T lymphocytopenia (HP:0005403)1.71989859
157Hypoplasia of the brainstem (HP:0002365)1.71592373
158Aplasia/Hypoplasia of the brainstem (HP:0007362)1.71592373
159Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69198504
160Abnormality of alanine metabolism (HP:0010916)1.69198504
161Hyperalaninemia (HP:0003348)1.69198504
162Clumsiness (HP:0002312)1.68855186
163Astigmatism (HP:0000483)1.68621340
164Abnormality of the parathyroid morphology (HP:0011766)1.67599258
165Hemiparesis (HP:0001269)1.65742744
166Narrow forehead (HP:0000341)1.65399026
167Abnormal ciliary motility (HP:0012262)1.64935477
168Hypochromic microcytic anemia (HP:0004840)1.63929157
169Hypoplastic labia majora (HP:0000059)1.63647082
170Tented upper lip vermilion (HP:0010804)1.63478647
171Preaxial foot polydactyly (HP:0001841)1.62704330
172Exotropia (HP:0000577)1.62002084
173Severe muscular hypotonia (HP:0006829)1.59586240
174Long nose (HP:0003189)1.59225919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.64805295
2ACVR1B3.36734010
3BMPR1B3.20490486
4RIPK43.14544228
5CDK193.11674215
6MAP3K42.90242673
7MAP2K72.89236612
8MAP3K122.79306151
9DAPK12.78216112
10CCNB12.77062393
11CASK2.42490889
12OXSR12.40442249
13TSSK62.40081069
14SIK32.39040916
15MST42.22563304
16NUAK12.22540432
17STK392.21272768
18NTRK32.18318963
19BMPR22.13179468
20MAP4K22.06681935
21EPHA42.02413024
22MAP4K12.01619134
23WNK32.00327469
24MARK11.92267689
25DAPK21.89607999
26GRK61.73455121
27BCR1.71659309
28GRK11.66242503
29MAPK131.62212896
30PINK11.61845766
31TNIK1.58069459
32CAMKK21.55534158
33ITK1.52166564
34MAP2K41.45360993
35MINK11.42251190
36MKNK21.42248292
37CSNK1G31.38891180
38SYK1.35353348
39BUB11.34158895
40CSNK1A1L1.32018909
41KSR21.28445561
42TGFBR11.24179618
43ZAK1.23663080
44SIK21.22212765
45CSNK1G11.21427383
46SGK31.20226243
47CSNK1G21.19788052
48SGK21.16422171
49WEE11.15937254
50STK101.11173340
51MAP3K91.08233640
52PAK31.08183819
53SGK2231.06761185
54SGK4941.06761185
55NEK91.04160008
56PLK21.03763630
57FGFR21.02921622
58PIK3CG1.01336279
59PDK10.99630045
60EIF2AK10.97029884
61NEK10.96998008
62RAF10.95543307
63PRPF4B0.92062413
64TYRO30.91238469
65INSRR0.90678229
66FES0.89820421
67WNK40.89118383
68TEC0.86437656
69CSF1R0.86161917
70BRD40.85413782
71PRKCQ0.85388198
72CAMKK10.85005483
73STK38L0.81992789
74NLK0.80396271
75RET0.79055677
76BTK0.78419008
77TXK0.78086869
78PRKCH0.77595765
79UHMK10.77183795
80ADRBK10.76443279
81FLT30.76205098
82CAMK1G0.75654674
83IRAK10.75078747
84PRKCE0.73291376
85MKNK10.72887399
86PDK40.72339741
87PDK30.72339741
88EEF2K0.70094569
89AKT30.67503506
90PTK2B0.67167019
91* CDK50.66620883
92TLK10.66536402
93NTRK20.66512007
94PLK30.65254914
95TIE10.65134755
96CDC70.64504032
97KSR10.64002748
98TNK20.63857963
99OBSCN0.63509197
100JAK20.62407173
101TAF10.60616355
102LATS10.60474626
103CAMK1D0.58988048
104BCKDK0.57616861
105STK110.56632355
106NME10.54363628
107EPHA30.53334110
108MAP3K140.52617043
109NEK20.52388625
110DYRK20.52150118
111CAMK40.51787013
112CAMK2A0.50546174
113TGFBR20.50387848
114EIF2AK30.50039426
115STK30.49895137
116BRSK10.48582982
117NTRK10.47758914
118PDK20.47291303
119LYN0.46971701
120FER0.46748205
121ALK0.46200775
122LCK0.44839976
123PAK60.44813929
124MAP3K70.44592372
125PRKAA20.44282829
126CDK30.44264292
127CAMK10.44124248
128GRK50.43093095
129MAP3K20.43081185
130CSNK1D0.42734272
131DYRK1A0.42228216
132PIK3CA0.41626424
133JAK10.41448285
134CAMK2B0.40776497
135PBK0.39753424
136FGFR30.39433821
137TAOK30.37085214
138PDPK10.36259476
139PRKAA10.34621421
140BRSK20.34331073
141SGK10.34295849
142YES10.34202341
143MELK0.34083496
144PLK10.33266518
145VRK10.33066737
146WNK10.29734978
147FGFR40.28803179
148CDK180.28400367
149PNCK0.27516712
150PRKCG0.26923685
151ADRBK20.26721522
152FYN0.26642226
153ERBB30.26319524
154RPS6KB10.26058028
155TRPM70.25949767

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.31494526
2Collecting duct acid secretion_Homo sapiens_hsa049662.82066088
3Phototransduction_Homo sapiens_hsa047442.67646159
4Selenocompound metabolism_Homo sapiens_hsa004502.60469915
5Long-term potentiation_Homo sapiens_hsa047202.38922379
6Vibrio cholerae infection_Homo sapiens_hsa051102.32096369
7Nicotine addiction_Homo sapiens_hsa050332.13476600
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12457307
9Morphine addiction_Homo sapiens_hsa050322.01155776
10Amphetamine addiction_Homo sapiens_hsa050311.96161646
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95558051
12Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.86160199
13ABC transporters_Homo sapiens_hsa020101.85905175
14Circadian entrainment_Homo sapiens_hsa047131.83635132
15Butanoate metabolism_Homo sapiens_hsa006501.78203321
16Dopaminergic synapse_Homo sapiens_hsa047281.76816998
17Ether lipid metabolism_Homo sapiens_hsa005651.75437444
18Vitamin B6 metabolism_Homo sapiens_hsa007501.74590086
19Dorso-ventral axis formation_Homo sapiens_hsa043201.71965780
20Nitrogen metabolism_Homo sapiens_hsa009101.67516328
21Salivary secretion_Homo sapiens_hsa049701.61964375
22Glutamatergic synapse_Homo sapiens_hsa047241.60895577
23Linoleic acid metabolism_Homo sapiens_hsa005911.60859198
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59497103
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58775100
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56889099
27Mismatch repair_Homo sapiens_hsa034301.55028577
28Primary immunodeficiency_Homo sapiens_hsa053401.53994609
29B cell receptor signaling pathway_Homo sapiens_hsa046621.52880571
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51502958
31Proteasome_Homo sapiens_hsa030501.50855791
32Gastric acid secretion_Homo sapiens_hsa049711.48489454
33GABAergic synapse_Homo sapiens_hsa047271.48234176
34Circadian rhythm_Homo sapiens_hsa047101.48162604
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46794866
36* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.46129160
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45011606
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44856730
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42795724
40Renin secretion_Homo sapiens_hsa049241.42291362
41Propanoate metabolism_Homo sapiens_hsa006401.42172133
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39508560
43Olfactory transduction_Homo sapiens_hsa047401.37178504
44T cell receptor signaling pathway_Homo sapiens_hsa046601.37155781
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33881127
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.28128079
47Oocyte meiosis_Homo sapiens_hsa041141.23385312
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.22800767
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22326783
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21998014
51Basal transcription factors_Homo sapiens_hsa030221.21356057
52Insulin secretion_Homo sapiens_hsa049111.17521053
53DNA replication_Homo sapiens_hsa030301.16785372
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16150956
55Tryptophan metabolism_Homo sapiens_hsa003801.13615617
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11899447
57Cholinergic synapse_Homo sapiens_hsa047251.11607347
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10849724
59RNA degradation_Homo sapiens_hsa030181.09856235
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08797894
61Long-term depression_Homo sapiens_hsa047301.07080835
62Serotonergic synapse_Homo sapiens_hsa047261.05853918
63Glycerolipid metabolism_Homo sapiens_hsa005611.05061306
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03676403
65Alcoholism_Homo sapiens_hsa050341.03375223
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03222203
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00858781
68* Regulation of autophagy_Homo sapiens_hsa041401.00450259
69Cocaine addiction_Homo sapiens_hsa050301.00141510
70Oxytocin signaling pathway_Homo sapiens_hsa049211.00010337
71Fanconi anemia pathway_Homo sapiens_hsa034600.99538072
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99333992
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96959981
74Non-small cell lung cancer_Homo sapiens_hsa052230.95775412
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95526675
76Taste transduction_Homo sapiens_hsa047420.94733404
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94599152
78Gap junction_Homo sapiens_hsa045400.93945783
79Base excision repair_Homo sapiens_hsa034100.87995372
80Peroxisome_Homo sapiens_hsa041460.87326259
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.86684504
82* Inositol phosphate metabolism_Homo sapiens_hsa005620.86108136
83beta-Alanine metabolism_Homo sapiens_hsa004100.85117259
84Caffeine metabolism_Homo sapiens_hsa002320.84576383
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.84193245
86Retinol metabolism_Homo sapiens_hsa008300.82887332
87Colorectal cancer_Homo sapiens_hsa052100.82798429
88Pancreatic secretion_Homo sapiens_hsa049720.82376092
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.82340136
90* Phagosome_Homo sapiens_hsa041450.82059274
91Calcium signaling pathway_Homo sapiens_hsa040200.81451824
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.80950320
93Nucleotide excision repair_Homo sapiens_hsa034200.80511277
94Chemical carcinogenesis_Homo sapiens_hsa052040.80228683
95ErbB signaling pathway_Homo sapiens_hsa040120.79843192
96Shigellosis_Homo sapiens_hsa051310.79548461
97Ovarian steroidogenesis_Homo sapiens_hsa049130.79456683
98TGF-beta signaling pathway_Homo sapiens_hsa043500.77362418
99Epstein-Barr virus infection_Homo sapiens_hsa051690.77024100
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76620524
101Fatty acid elongation_Homo sapiens_hsa000620.74120846
102Antigen processing and presentation_Homo sapiens_hsa046120.72415448
103GnRH signaling pathway_Homo sapiens_hsa049120.72308136
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.70343895
105Fatty acid biosynthesis_Homo sapiens_hsa000610.69475017
106Non-homologous end-joining_Homo sapiens_hsa034500.68597477
107Mineral absorption_Homo sapiens_hsa049780.67832332
108Chemokine signaling pathway_Homo sapiens_hsa040620.67433942
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65725935
110Glioma_Homo sapiens_hsa052140.64727255
111Endocytosis_Homo sapiens_hsa041440.64572997
112Platelet activation_Homo sapiens_hsa046110.62462263
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62137088
114Lysosome_Homo sapiens_hsa041420.60090628
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59953655
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59599858
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59543342
118Protein export_Homo sapiens_hsa030600.59360550
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58881400
120cAMP signaling pathway_Homo sapiens_hsa040240.57711472
121Hedgehog signaling pathway_Homo sapiens_hsa043400.57165688
122Homologous recombination_Homo sapiens_hsa034400.56872562
123Axon guidance_Homo sapiens_hsa043600.56163890
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55867480
125Estrogen signaling pathway_Homo sapiens_hsa049150.54701656
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54612652
127MAPK signaling pathway_Homo sapiens_hsa040100.54145842
128Ras signaling pathway_Homo sapiens_hsa040140.53942005
129mTOR signaling pathway_Homo sapiens_hsa041500.52756987
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52133047
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52054873
132VEGF signaling pathway_Homo sapiens_hsa043700.51522602
133Osteoclast differentiation_Homo sapiens_hsa043800.50986903
134FoxO signaling pathway_Homo sapiens_hsa040680.50895529
135Spliceosome_Homo sapiens_hsa030400.50340341
136Histidine metabolism_Homo sapiens_hsa003400.50233670
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.50140301
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49880536
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49250080
140Viral carcinogenesis_Homo sapiens_hsa052030.48340917
141RNA transport_Homo sapiens_hsa030130.47974145
142Rheumatoid arthritis_Homo sapiens_hsa053230.47682003
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47387683
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45734714
145Cell cycle_Homo sapiens_hsa041100.45135928
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44834704
147Type II diabetes mellitus_Homo sapiens_hsa049300.44710409
148Basal cell carcinoma_Homo sapiens_hsa052170.44411191
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43754091
150Thyroid hormone synthesis_Homo sapiens_hsa049180.43543558
151Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42919039
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.42197674
153RNA polymerase_Homo sapiens_hsa030200.41926418
154Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40143028
155Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39876195
156Endometrial cancer_Homo sapiens_hsa052130.39813540
157Pancreatic cancer_Homo sapiens_hsa052120.38946498
158mRNA surveillance pathway_Homo sapiens_hsa030150.38518140
159Lysine degradation_Homo sapiens_hsa003100.38012677

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