PIK3CA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)3.80617849
2positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21474202
3germinal center formation (GO:0002467)3.10787096
4* phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.05800524
5cellular response to ethanol (GO:0071361)3.00580035
6detection of molecule of bacterial origin (GO:0032490)3.00502525
7interkinetic nuclear migration (GO:0022027)2.99107706
8regulation of B cell receptor signaling pathway (GO:0050855)2.98713027
9layer formation in cerebral cortex (GO:0021819)2.96816089
10B cell receptor signaling pathway (GO:0050853)2.96300269
11regulation of gamma-delta T cell activation (GO:0046643)2.94982016
12regulation of gamma-delta T cell differentiation (GO:0045586)2.93645175
13histone H3-K36 demethylation (GO:0070544)2.92940657
14Rap protein signal transduction (GO:0032486)2.91030100
15monoubiquitinated protein deubiquitination (GO:0035520)2.90705460
16cellular extravasation (GO:0045123)2.88839279
17negative regulation of erythrocyte differentiation (GO:0045647)2.88617923
18dendrite morphogenesis (GO:0048813)2.74944829
19embryonic process involved in female pregnancy (GO:0060136)2.73367834
20positive regulation of cardiac muscle hypertrophy (GO:0010613)2.72475159
21positive regulation of muscle hypertrophy (GO:0014742)2.72475159
22hypotonic response (GO:0006971)2.69172057
23definitive hemopoiesis (GO:0060216)2.68437798
24histone lysine demethylation (GO:0070076)2.67747867
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64448721
26nerve growth factor signaling pathway (GO:0038180)2.63597667
27regulation of histone H3-K27 methylation (GO:0061085)2.63495748
28response to muramyl dipeptide (GO:0032495)2.62573055
29histone H3-K9 demethylation (GO:0033169)2.62026938
30locomotory exploration behavior (GO:0035641)2.61919016
31histone demethylation (GO:0016577)2.58801953
32response to interleukin-15 (GO:0070672)2.56991514
33JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56737232
34cellular response to epinephrine stimulus (GO:0071872)2.56058152
35cellular potassium ion homeostasis (GO:0030007)2.53975299
36cerebellar Purkinje cell differentiation (GO:0021702)2.53753468
37negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.53615631
38protein K11-linked deubiquitination (GO:0035871)2.51514712
39macrophage activation involved in immune response (GO:0002281)2.49047559
40B cell homeostasis (GO:0001782)2.48760488
41positive T cell selection (GO:0043368)2.48631040
42cellular response to nerve growth factor stimulus (GO:1990090)2.46408982
43response to nerve growth factor (GO:1990089)2.46408982
44regulation of NFAT protein import into nucleus (GO:0051532)2.46066132
45photoreceptor cell differentiation (GO:0046530)2.46002321
46eye photoreceptor cell differentiation (GO:0001754)2.46002321
47regulation of dendritic spine morphogenesis (GO:0061001)2.43935262
48interleukin-6-mediated signaling pathway (GO:0070102)2.42316537
49phospholipid translocation (GO:0045332)2.41005196
50lipid translocation (GO:0034204)2.41005196
51insulin-like growth factor receptor signaling pathway (GO:0048009)2.40961104
52modulation by symbiont of host immune response (GO:0052553)2.40728194
53positive regulation by symbiont of host defense response (GO:0052509)2.40728194
54modulation by symbiont of host defense response (GO:0052031)2.40728194
55modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.40728194
56modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.40728194
57positive regulation by organism of defense response of other organism involved in symbiotic interact2.40728194
58regulation of short-term neuronal synaptic plasticity (GO:0048172)2.39929993
59platelet-derived growth factor receptor signaling pathway (GO:0048008)2.39381522
60peptidyl-threonine phosphorylation (GO:0018107)2.38822564
61negative thymic T cell selection (GO:0045060)2.36920973
62protein targeting to Golgi (GO:0000042)2.36667383
63growth hormone receptor signaling pathway (GO:0060396)2.36430748
64lymph vessel development (GO:0001945)2.35339583
65neuron recognition (GO:0008038)2.34437683
66dendritic spine morphogenesis (GO:0060997)2.34170102
67presynaptic membrane assembly (GO:0097105)2.33563651
68positive regulation of cellular amide metabolic process (GO:0034250)2.32552218
69oxygen transport (GO:0015671)2.32447881
70hepatocyte apoptotic process (GO:0097284)2.32170926
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31142668
72peptidyl-threonine modification (GO:0018210)2.30411993
73vocalization behavior (GO:0071625)2.30411858
74positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.28488508
75nucleus localization (GO:0051647)2.27792411
76retrograde transport, vesicle recycling within Golgi (GO:0000301)2.27455659
77negative T cell selection (GO:0043383)2.26934271
78regulation of nucleobase-containing compound transport (GO:0032239)2.26607767
79response to laminar fluid shear stress (GO:0034616)2.26272169
80nuclear pore complex assembly (GO:0051292)2.25673517
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.24825070
82potassium ion import (GO:0010107)2.24803540
83regulation of RNA export from nucleus (GO:0046831)2.24364212
84histone H3-K4 trimethylation (GO:0080182)2.23291602
85axonal fasciculation (GO:0007413)2.23236471
86gamma-aminobutyric acid transport (GO:0015812)2.22512637
87negative regulation of cell killing (GO:0031342)2.22177522
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.22177522
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20496121
90establishment of protein localization to Golgi (GO:0072600)2.20324446
91negative regulation of NF-kappaB import into nucleus (GO:0042347)2.19460919
92cellular response to growth hormone stimulus (GO:0071378)2.19232388
93regulation of protein polyubiquitination (GO:1902914)2.18936044
94protein dealkylation (GO:0008214)2.18454167
95protein demethylation (GO:0006482)2.18454167
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.18252903
97regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.17928839
98protein localization to endosome (GO:0036010)2.17337761
99detection of external biotic stimulus (GO:0098581)2.17119393
100positive regulation of potassium ion transport (GO:0043268)2.16683703
101axon extension (GO:0048675)2.16584605
102regulation of necroptotic process (GO:0060544)2.16187249
103neutrophil activation involved in immune response (GO:0002283)2.16092805
104chemical homeostasis within a tissue (GO:0048875)2.15672302
105cytoplasmic mRNA processing body assembly (GO:0033962)2.15447621
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.15116053
107regulation of clathrin-mediated endocytosis (GO:2000369)2.14789899
108positive regulation of B cell differentiation (GO:0045579)2.14208250
109tolerance induction (GO:0002507)2.14103026
110T cell migration (GO:0072678)2.13868969
111positive regulation of granulocyte differentiation (GO:0030854)2.13461804
112regulation of dendritic spine development (GO:0060998)2.13299427
113regulation of synaptic vesicle exocytosis (GO:2000300)2.13005866
114negative regulation of sodium ion transport (GO:0010766)2.12182691
115negative regulation of T cell mediated immunity (GO:0002710)2.12138476
116glial cell proliferation (GO:0014009)2.11989061
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.11691955
118negative regulation of T-helper cell differentiation (GO:0045623)2.11260464
119negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.11260464
120cerebral cortex radially oriented cell migration (GO:0021799)2.11205554
121negative regulation of neurotransmitter secretion (GO:0046929)2.11010950
122ionotropic glutamate receptor signaling pathway (GO:0035235)2.09511702
123regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.09384262
124negative regulation of potassium ion transmembrane transport (GO:1901380)2.09125006
125positive regulation of Rap GTPase activity (GO:0032854)2.08959668
126regulation of macrophage cytokine production (GO:0010935)2.08888291
127T cell selection (GO:0045058)2.08469160
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.08451629
129negative regulation of catenin import into nucleus (GO:0035414)2.08277205
130response to epinephrine (GO:0071871)2.07822714
131detection of other organism (GO:0098543)2.07312542
132positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.07273193
133regulation of membrane repolarization (GO:0060306)2.06799884
134regulation of Rap GTPase activity (GO:0032317)2.06600595
135positive thymic T cell selection (GO:0045059)2.06191893
136parental behavior (GO:0060746)2.06144334
137presynaptic membrane organization (GO:0097090)2.05901890
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.05509799
139regulation of Rac protein signal transduction (GO:0035020)2.05038702
140myelin assembly (GO:0032288)2.04813235
141prepulse inhibition (GO:0060134)2.04781239
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.04495680
143establishment of endothelial barrier (GO:0061028)2.04264035
144protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.04232380
145coronary vasculature morphogenesis (GO:0060977)2.03863783
146phosphatidylinositol dephosphorylation (GO:0046856)2.03848462
147clathrin coat assembly (GO:0048268)2.03483933
148regulation of sarcomere organization (GO:0060297)2.02544602
149neuron cell-cell adhesion (GO:0007158)2.02205799
150cerebral cortex cell migration (GO:0021795)2.02123960
151surfactant homeostasis (GO:0043129)2.01693360
152regulation of cell communication by electrical coupling (GO:0010649)2.01343032
153maternal behavior (GO:0042711)2.01182502
154relaxation of cardiac muscle (GO:0055119)2.00183275
155plasma membrane repair (GO:0001778)1.99689876
156regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.99652280
157suckling behavior (GO:0001967)1.97812335
158ganglion development (GO:0061548)1.97147522
159mating behavior (GO:0007617)1.96887309
160limb bud formation (GO:0060174)1.96788309
161regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.96680515
162regulation of excitatory postsynaptic membrane potential (GO:0060079)1.96357246
163positive regulation of dendritic spine morphogenesis (GO:0061003)1.95769707
164neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.95416628
165phospholipid dephosphorylation (GO:0046839)1.95143900
166activation of protein kinase A activity (GO:0034199)1.94601901
167negative regulation of synaptic transmission, GABAergic (GO:0032229)1.94542677
168neuronal ion channel clustering (GO:0045161)1.93546645
169regulation of cardiac muscle hypertrophy (GO:0010611)1.92964708
170negative regulation of Rho protein signal transduction (GO:0035024)1.92885503
171cAMP catabolic process (GO:0006198)1.92479916
172import into cell (GO:0098657)1.91474133
173camera-type eye morphogenesis (GO:0048593)1.91464716
174glutamate receptor signaling pathway (GO:0007215)1.91252935
175protein localization to synapse (GO:0035418)1.91041153
176membrane repolarization during cardiac muscle cell action potential (GO:0086013)1.90790572
177gamma-aminobutyric acid signaling pathway (GO:0007214)1.90587273
178regulation of potassium ion transmembrane transport (GO:1901379)1.90460885
179embryonic retina morphogenesis in camera-type eye (GO:0060059)1.90157705
180regulation of potassium ion transmembrane transporter activity (GO:1901016)1.89786279
181regulation of muscle hypertrophy (GO:0014743)1.89607064
182L-amino acid import (GO:0043092)1.89127765
183regulation of glutamate receptor signaling pathway (GO:1900449)1.88889869
184synapse assembly (GO:0007416)1.88840918
185establishment of nucleus localization (GO:0040023)1.87763769
186neuromuscular junction development (GO:0007528)1.87254981
187vesicle transport along microtubule (GO:0047496)1.86810109
188cyclic nucleotide catabolic process (GO:0009214)1.86631350
189detection of calcium ion (GO:0005513)1.86607457
190regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)1.86375565
191regulation of axon extension involved in axon guidance (GO:0048841)1.85872997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.15891245
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93543261
3GBX2_23144817_ChIP-Seq_PC3_Human2.72945545
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55665716
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.53901709
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.48719230
7GATA1_22025678_ChIP-Seq_K562_Human2.38985183
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35263675
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.32184468
10TAF15_26573619_Chip-Seq_HEK293_Human2.27987844
11RUNX_20019798_ChIP-Seq_JUKART_Human2.18660681
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10197387
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03733736
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.01424450
15AR_21572438_ChIP-Seq_LNCaP_Human1.99878483
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96108195
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.95243806
18JARID2_20064375_ChIP-Seq_MESCs_Mouse1.95241213
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92814864
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91487184
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.90068827
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88749948
23IRF8_22096565_ChIP-ChIP_GC-B_Human1.88579050
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88088976
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87884554
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85824474
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84227482
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84227482
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.82187219
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78588973
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76591715
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.72966405
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72848553
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70009663
35SMAD4_21799915_ChIP-Seq_A2780_Human1.65922895
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65659401
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.64595341
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64510788
39VDR_24787735_ChIP-Seq_THP-1_Human1.63332569
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61472521
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.60826965
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.60603154
43AHR_22903824_ChIP-Seq_MCF-7_Human1.59221994
44MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59209173
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57878111
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55710530
47TP53_16413492_ChIP-PET_HCT116_Human1.54270100
48P300_19829295_ChIP-Seq_ESCs_Human1.53950959
49* GATA2_21666600_ChIP-Seq_HMVEC_Human1.53690530
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47667218
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44496095
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43441484
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43419101
54DROSHA_22980978_ChIP-Seq_HELA_Human1.43291402
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41910180
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41321277
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.41267491
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40931621
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.40748156
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40569055
61TP53_18474530_ChIP-ChIP_U2OS_Human1.39939691
62SCL_19346495_ChIP-Seq_HPC-7_Human1.39459680
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.38971001
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.37590613
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35952215
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35392990
67STAT3_23295773_ChIP-Seq_U87_Human1.32516962
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32226899
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29707697
70* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28783206
71* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28783206
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.28403639
73IGF1R_20145208_ChIP-Seq_DFB_Human1.28220104
74ER_23166858_ChIP-Seq_MCF-7_Human1.27557238
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.26258754
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.25252111
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.24237101
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.23477195
79IRF8_21731497_ChIP-ChIP_J774_Mouse1.23032810
80AR_25329375_ChIP-Seq_VCAP_Human1.22563748
81TCF4_23295773_ChIP-Seq_U87_Human1.21653781
82PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21170900
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20631315
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20475816
85BCAT_22108803_ChIP-Seq_LS180_Human1.20246487
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19408409
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19215887
88GATA1_19941826_ChIP-Seq_K562_Human1.17888082
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17859531
90BRD4_25478319_ChIP-Seq_HGPS_Human1.17813017
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16927524
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.16703520
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16626824
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14470439
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14313201
96RXR_22108803_ChIP-Seq_LS180_Human1.13907080
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.13766702
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13599800
99MYB_26560356_Chip-Seq_TH2_Human1.12881958
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12167763
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12096597
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11876862
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11876862
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11138997
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10622561
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10578658
107TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10405953
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10018839
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09869497
110AR_19668381_ChIP-Seq_PC3_Human1.09766415
111FUS_26573619_Chip-Seq_HEK293_Human1.09752774
112PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08591690
113PRDM14_20953172_ChIP-Seq_ESCs_Human1.08167406
114GATA2_19941826_ChIP-Seq_K562_Human1.08095079
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.07869308
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07248152
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07248152
118CJUN_26792858_Chip-Seq_BT549_Human1.07030782
119NANOG_18555785_Chip-Seq_ESCs_Mouse1.06737458
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05189691
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05096817
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04979362
123ESR1_20079471_ChIP-ChIP_T-47D_Human1.04429685
124SPI1_23127762_ChIP-Seq_K562_Human1.04256820
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03999364
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03182257
127SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02349010
128PU_27001747_Chip-Seq_BMDM_Mouse1.02323941
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.02141122
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01616937
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01537166
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01427323
133TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01158025
134TCF7_22412390_ChIP-Seq_EML_Mouse1.00908303
135VDR_22108803_ChIP-Seq_LS180_Human1.00558640
136Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00556582
137MYB_26560356_Chip-Seq_TH1_Human1.00263574
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99541421
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98483282
140TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98010248
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97671378
142IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97608938
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97026222
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.95800352
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95344272
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.94254204
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94215033
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93821202
149GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93145188
150TP63_23658742_ChIP-Seq_EP156T_Human0.92706886
151EZH2_27294783_Chip-Seq_NPCs_Mouse0.91195453
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90718656
153KDM2B_26808549_Chip-Seq_REH_Human0.88830068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.74947525
2MP0003787_abnormal_imprinting3.10330326
3MP0008057_abnormal_DNA_replication2.99568583
4MP0003724_increased_susceptibility_to2.74350933
5MP0000013_abnormal_adipose_tissue2.60706156
6MP0010352_gastrointestinal_tract_polyps2.46707622
7MP0003763_abnormal_thymus_physiology2.43004399
8MP0003828_pulmonary_edema2.40804191
9MP0003880_abnormal_central_pattern2.20307848
10MP0004130_abnormal_muscle_cell2.17863578
11MP0003656_abnormal_erythrocyte_physiolo2.16060670
12MP0004859_abnormal_synaptic_plasticity2.14963638
13MP0005551_abnormal_eye_electrophysiolog2.12275644
14MP0001958_emphysema2.09858807
15MP0003300_gastrointestinal_ulcer2.07248874
16MP0002877_abnormal_melanocyte_morpholog2.01358604
17MP0010234_abnormal_vibrissa_follicle1.95978552
18MP0004270_analgesia1.93670779
19MP0003436_decreased_susceptibility_to1.90961372
20MP0003635_abnormal_synaptic_transmissio1.88891532
21MP0003705_abnormal_hypodermis_morpholog1.87621168
22MP0005409_darkened_coat_color1.84182808
23MP0001486_abnormal_startle_reflex1.83374804
24MP0009780_abnormal_chondrocyte_physiolo1.81440397
25MP0004808_abnormal_hematopoietic_stem1.78854794
26MP0000751_myopathy1.77764888
27MP0000465_gastrointestinal_hemorrhage1.74213340
28MP0001177_atelectasis1.72686355
29MP0009745_abnormal_behavioral_response1.70080989
30MP0000003_abnormal_adipose_tissue1.69904738
31MP0004484_altered_response_of1.69106132
32MP0003191_abnormal_cellular_cholesterol1.69038834
33MP0005623_abnormal_meninges_morphology1.67440367
34MP0002396_abnormal_hematopoietic_system1.66494080
35MP0003045_fibrosis1.66472214
36MP0001835_abnormal_antigen_presentation1.65947082
37MP0000778_abnormal_nervous_system1.63698988
38MP0004134_abnormal_chest_morphology1.61491590
39MP0008260_abnormal_autophagy1.61065082
40MP0003221_abnormal_cardiomyocyte_apopto1.57249493
41MP0001851_eye_inflammation1.56484955
42MP0002067_abnormal_sensory_capabilities1.55708073
43MP0001800_abnormal_humoral_immune1.55468007
44MP0004742_abnormal_vestibular_system1.54139753
45MP0001968_abnormal_touch/_nociception1.53040384
46MP0003950_abnormal_plasma_membrane1.53020864
47MP0002063_abnormal_learning/memory/cond1.52671479
48MP0009046_muscle_twitch1.51832914
49MP0005248_abnormal_Harderian_gland1.51201682
50MP0005076_abnormal_cell_differentiation1.48632376
51MP0004883_abnormal_blood_vessel1.48212197
52MP0000685_abnormal_immune_system1.47624522
53MP0003303_peritoneal_inflammation1.46806630
54* MP0001879_abnormal_lymphatic_vessel1.46777657
55MP0002009_preneoplasia1.45799196
56MP0008438_abnormal_cutaneous_collagen1.42857116
57MP0002064_seizures1.39956845
58MP0003566_abnormal_cell_adhesion1.38157067
59MP0005000_abnormal_immune_tolerance1.38018426
60MP0005171_absent_coat_pigmentation1.37592786
61MP0001790_abnormal_immune_system1.36633896
62MP0005387_immune_system_phenotype1.36633896
63MP0001440_abnormal_grooming_behavior1.35816021
64MP0002184_abnormal_innervation1.35252217
65MP0002734_abnormal_mechanical_nocicepti1.34653366
66MP0001299_abnormal_eye_distance/1.33659922
67MP0005164_abnormal_response_to1.33153043
68MP0002572_abnormal_emotion/affect_behav1.33137032
69MP0006054_spinal_hemorrhage1.33045942
70MP0004185_abnormal_adipocyte_glucose1.31637019
71MP0002419_abnormal_innate_immunity1.30884338
72MP0002452_abnormal_antigen_presenting1.29701517
73MP0003690_abnormal_glial_cell1.27732879
74MP0006276_abnormal_autonomic_nervous1.27432413
75MP0004145_abnormal_muscle_electrophysio1.26039798
76MP0005503_abnormal_tendon_morphology1.25473280
77MP0005451_abnormal_body_composition1.25317912
78MP0008569_lethality_at_weaning1.23382866
79MP0001984_abnormal_olfaction1.23023456
80MP0005375_adipose_tissue_phenotype1.22802527
81MP0002420_abnormal_adaptive_immunity1.22546783
82MP0002723_abnormal_immune_serum1.22184767
83MP0002090_abnormal_vision1.21689029
84MP0002998_abnormal_bone_remodeling1.20832957
85MP0004947_skin_inflammation1.20805427
86MP0000767_abnormal_smooth_muscle1.20539571
87MP0002735_abnormal_chemical_nociception1.19644456
88MP0002166_altered_tumor_susceptibility1.19534166
89MP0001819_abnormal_immune_cell1.19496255
90MP0002133_abnormal_respiratory_system1.19001844
91MP0005388_respiratory_system_phenotype1.19001844
92MP0002398_abnormal_bone_marrow1.17936274
93MP0001485_abnormal_pinna_reflex1.17652041
94MP0002405_respiratory_system_inflammati1.16026312
95MP0003279_aneurysm1.13247960
96MP0002332_abnormal_exercise_endurance1.12776215
97MP0004885_abnormal_endolymph1.12672115
98MP0000920_abnormal_myelination1.09098262
99MP0005253_abnormal_eye_physiology1.08963578
100MP0003453_abnormal_keratinocyte_physiol1.07667343
101MP0000703_abnormal_thymus_morphology1.07217146
102MP0004084_abnormal_cardiac_muscle1.06146177
103MP0002272_abnormal_nervous_system1.06087853
104MP0005275_abnormal_skin_tensile1.04228490
105MP0003868_abnormal_feces_composition1.03995773
106MP0003091_abnormal_cell_migration1.02556476
107MP0003448_altered_tumor_morphology1.00612731
108MP0003183_abnormal_peptide_metabolism0.99796375
109MP0000716_abnormal_immune_system0.99771155
110MP0005464_abnormal_platelet_physiology0.98834172
111MP0008004_abnormal_stomach_pH0.98595570
112* MP0004215_abnormal_myocardial_fiber0.97842334
113MP0001915_intracranial_hemorrhage0.97835416
114MP0001533_abnormal_skeleton_physiology0.97828453
115MP0002108_abnormal_muscle_morphology0.97350596
116MP0005423_abnormal_somatic_nervous0.96704696
117MP0004924_abnormal_behavior0.96495908
118MP0005386_behavior/neurological_phenoty0.96495908
119MP0004381_abnormal_hair_follicle0.95820202
120MP0001545_abnormal_hematopoietic_system0.94986099
121MP0005397_hematopoietic_system_phenotyp0.94986099
122MP0005310_abnormal_salivary_gland0.94624595
123MP0002882_abnormal_neuron_morphology0.94395114
124MP0002138_abnormal_hepatobiliary_system0.93856207
125MP0003121_genomic_imprinting0.93664812
126* MP0005195_abnormal_posterior_eye0.92698248
127MP0005025_abnormal_response_to0.92251826
128* MP0005621_abnormal_cell_physiology0.92212627
129MP0004036_abnormal_muscle_relaxation0.91062739
130MP0009250_abnormal_appendicular_skeleto0.90416985
131MP0005666_abnormal_adipose_tissue0.90214417
132MP0002557_abnormal_social/conspecific_i0.88853081
133MP0010386_abnormal_urinary_bladder0.88408733
134MP0010155_abnormal_intestine_physiology0.88001804
135MP0002722_abnormal_immune_system0.87923736
136MP0002896_abnormal_bone_mineralization0.87156707
137MP0002736_abnormal_nociception_after0.86662666
138MP0004085_abnormal_heartbeat0.85795554
139MP0000689_abnormal_spleen_morphology0.85447029
140MP0003385_abnormal_body_wall0.84612337
141MP0006138_congestive_heart_failure0.84377033
142MP0001853_heart_inflammation0.83229841
143MP0003633_abnormal_nervous_system0.83004973
144MP0002928_abnormal_bile_duct0.82679880
145* MP0005620_abnormal_muscle_contractility0.82586835
146MP0002837_dystrophic_cardiac_calcinosis0.82585586
147MP0006072_abnormal_retinal_apoptosis0.82145385
148MP0009785_altered_susceptibility_to0.81891968
149MP0001943_abnormal_respiration0.81747033
150MP0001502_abnormal_circadian_rhythm0.81262733
151MP0000858_altered_metastatic_potential0.80766988
152MP0004272_abnormal_basement_membrane0.80209454
153MP0002006_tumorigenesis0.79596357
154MP0001324_abnormal_eye_pigmentation0.79594741
155MP0005023_abnormal_wound_healing0.79547840
156MP0002168_other_aberrant_phenotype0.79482443
157* MP0000249_abnormal_blood_vessel0.79367798
158MP0002971_abnormal_brown_adipose0.79144937
159MP0010678_abnormal_skin_adnexa0.78966376
160MP0004510_myositis0.78849757
161MP0001188_hyperpigmentation0.78555713
162MP0002229_neurodegeneration0.77583065
163MP0009384_cardiac_valve_regurgitation0.77294890
164MP0003172_abnormal_lysosome_physiology0.77037221
165MP0010307_abnormal_tumor_latency0.76679604
166* MP0009115_abnormal_fat_cell0.76380385
167MP0000733_abnormal_muscle_development0.76114804
168MP0000015_abnormal_ear_pigmentation0.75720384
169MP0002102_abnormal_ear_morphology0.75078623
170MP0000427_abnormal_hair_cycle0.75008666
171MP0001501_abnormal_sleep_pattern0.73792493
172MP0004782_abnormal_surfactant_physiolog0.73646526
173MP0002752_abnormal_somatic_nervous0.73116566
174* MP0002972_abnormal_cardiac_muscle0.72307944

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.96602328
2Exotropia (HP:0000577)3.33857396
3Eczematoid dermatitis (HP:0000976)3.26115516
4Asymmetry of the thorax (HP:0001555)3.22470617
5Febrile seizures (HP:0002373)3.19891070
6Focal motor seizures (HP:0011153)2.77330790
7Spontaneous hematomas (HP:0007420)2.75944609
8Macroorchidism (HP:0000053)2.70061611
9T lymphocytopenia (HP:0005403)2.68269939
10Absent frontal sinuses (HP:0002688)2.63055509
11Cone-rod dystrophy (HP:0000548)2.61451344
12Atonic seizures (HP:0010819)2.61277632
13Heterotopia (HP:0002282)2.58382186
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.57624043
15Excessive salivation (HP:0003781)2.49330051
16Drooling (HP:0002307)2.49330051
17Abnormality of the fingertips (HP:0001211)2.48305489
18Arterial tortuosity (HP:0005116)2.48271941
19Abnormality of T cell number (HP:0011839)2.45876042
20Focal seizures (HP:0007359)2.43419559
21Widely spaced teeth (HP:0000687)2.41776460
22Dilatation of the ascending aorta (HP:0005111)2.41004826
23Hypoplasia of the iris (HP:0007676)2.40856597
24Thyroid carcinoma (HP:0002890)2.40534998
25Central scotoma (HP:0000603)2.33540361
26Blue irides (HP:0000635)2.32309284
27Osteolytic defects of the phalanges of the hand (HP:0009771)2.30946559
28Osteolytic defects of the hand bones (HP:0009699)2.30946559
29Abnormality of the left ventricular outflow tract (HP:0011103)2.29329770
30Subaortic stenosis (HP:0001682)2.29329770
31Hematochezia (HP:0002573)2.28659271
32Inappropriate behavior (HP:0000719)2.27744380
33Intellectual disability, moderate (HP:0002342)2.26820449
34Vascular tortuosity (HP:0004948)2.26288013
35Spondylolisthesis (HP:0003302)2.24065001
36Prolonged QT interval (HP:0001657)2.23530411
37Hyperthyroidism (HP:0000836)2.20837861
38Chorioretinal atrophy (HP:0000533)2.19413636
39Acute myeloid leukemia (HP:0004808)2.18700704
40Poor eye contact (HP:0000817)2.18390190
41Recurrent bacterial skin infections (HP:0005406)2.18331474
42Lower limb amyotrophy (HP:0007210)2.17747082
43Hypoplastic ischia (HP:0003175)2.15943605
44Broad-based gait (HP:0002136)2.13735763
45Cellulitis (HP:0100658)2.11099924
46Aortic aneurysm (HP:0004942)2.09558432
47Impaired social interactions (HP:0000735)2.08914456
48Abnormal social behavior (HP:0012433)2.08914456
49Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.08670974
50Progressive inability to walk (HP:0002505)2.08011188
51Insidious onset (HP:0003587)2.06289649
52Termporal pattern (HP:0011008)2.06289649
53Mitral valve prolapse (HP:0001634)2.06059599
54Abnormality of the ischium (HP:0003174)2.06009083
55Dislocated radial head (HP:0003083)2.05763849
56Generalized hypopigmentation of hair (HP:0011358)2.04729373
57* Subacute progressive viral hepatitis (HP:0006572)2.02885776
58Absence seizures (HP:0002121)2.02012460
59Curly hair (HP:0002212)2.01723806
60Difficulty running (HP:0009046)2.01700241
61Action tremor (HP:0002345)2.01469208
62Exercise-induced myalgia (HP:0003738)2.01411561
63Broad ribs (HP:0000885)2.01297048
64Epileptic encephalopathy (HP:0200134)2.00369644
65Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00005974
66Papilledema (HP:0001085)1.99904327
67Gingivitis (HP:0000230)1.99777026
68Abnormality of salivation (HP:0100755)1.98228950
69Buphthalmos (HP:0000557)1.97365951
70Dysmetric saccades (HP:0000641)1.96859704
71Distal lower limb amyotrophy (HP:0008944)1.96569696
72Abnormality of the nasal septum (HP:0000419)1.95504135
73Midline defect of the nose (HP:0004122)1.95060392
74Recurrent abscess formation (HP:0002722)1.94825887
75Chronic hepatic failure (HP:0100626)1.92183379
76Congenital stationary night blindness (HP:0007642)1.89724399
77Aqueductal stenosis (HP:0002410)1.87943071
78Conjunctival telangiectasia (HP:0000524)1.87824989
79Hypophosphatemic rickets (HP:0004912)1.87684484
80Aortic dissection (HP:0002647)1.87035746
81Fair hair (HP:0002286)1.86904698
82Generalized tonic-clonic seizures (HP:0002069)1.86849340
83Spinal cord lesions (HP:0100561)1.86762552
84Syringomyelia (HP:0003396)1.86762552
85Truncal obesity (HP:0001956)1.86434494
86Gastrointestinal infarctions (HP:0005244)1.86323338
87Truncal ataxia (HP:0002078)1.86229203
88Osteomyelitis (HP:0002754)1.84976216
89Abnormality of the radial head (HP:0003995)1.84713904
90Relative macrocephaly (HP:0004482)1.84574393
91Peritonitis (HP:0002586)1.84042671
92Mild short stature (HP:0003502)1.83021944
93* Overgrowth (HP:0001548)1.83002537
94Abnormality of the frontal sinuses (HP:0002687)1.82759626
95Hyperventilation (HP:0002883)1.82714815
96Obstructive sleep apnea (HP:0002870)1.81483570
97Aneurysm (HP:0002617)1.81256870
98Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81241869
99Protruding tongue (HP:0010808)1.81236738
100Slow saccadic eye movements (HP:0000514)1.79887965
101Coarse hair (HP:0002208)1.79770630
102Cerebral aneurysm (HP:0004944)1.79261277
103Decreased subcutaneous fat (HP:0001002)1.77678551
104Ankyloglossia (HP:0010296)1.77219670
105Thick nail (HP:0001805)1.77166133
106Dysdiadochokinesis (HP:0002075)1.75826266
107Gaze-evoked nystagmus (HP:0000640)1.74335780
108Recurrent bronchitis (HP:0002837)1.73815869
109Cystic hygroma (HP:0000476)1.73576996
110Protrusio acetabuli (HP:0003179)1.73567823
111Thickened calvaria (HP:0002684)1.72936503
112Muscle hypertrophy of the lower extremities (HP:0008968)1.72786003
113Hyporeflexia of lower limbs (HP:0002600)1.71547359
114Infantile muscular hypotonia (HP:0008947)1.71155366
115Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.70512700
116Persistence of primary teeth (HP:0006335)1.69349389
117Onion bulb formation (HP:0003383)1.69163958
118Deep philtrum (HP:0002002)1.68696072
119Tubulointerstitial nephritis (HP:0001970)1.68197243
120Volvulus (HP:0002580)1.68195174
121Recurrent viral infections (HP:0004429)1.67879629
122Abnormality of the calf musculature (HP:0001430)1.67749059
123* Viral hepatitis (HP:0006562)1.67270413
124Venous abnormality (HP:0002624)1.67124087
125Wormian bones (HP:0002645)1.66923069
126Abnormality of incisor morphology (HP:0011063)1.66766422
127Fatigue (HP:0012378)1.66522375
128Cortical dysplasia (HP:0002539)1.66480333
129Increased variability in muscle fiber diameter (HP:0003557)1.66369666
130Submucous cleft hard palate (HP:0000176)1.65728635
131Scotoma (HP:0000575)1.65009750
132Abnormality of the sella turcica (HP:0002679)1.64961479
133Cubitus valgus (HP:0002967)1.64742439
134Slender build (HP:0001533)1.64633914
135Disproportionate tall stature (HP:0001519)1.63486181
136Calf muscle hypertrophy (HP:0008981)1.63293168
137Broad metatarsal (HP:0001783)1.63278243
138Narrow palate (HP:0000189)1.63267249
139Venous insufficiency (HP:0005293)1.62530802
140Progressive cerebellar ataxia (HP:0002073)1.62335721
141Autoimmune hemolytic anemia (HP:0001890)1.61696606
142Macular degeneration (HP:0000608)1.61441436
143Dialeptic seizures (HP:0011146)1.61363795
144Gingival bleeding (HP:0000225)1.61179800
145Abnormality of macrophages (HP:0004311)1.60524777
146Abnormal platelet volume (HP:0011876)1.60324890
147Decreased motor nerve conduction velocity (HP:0003431)1.59807761
148Polycythemia (HP:0001901)1.59616847
149Periodontitis (HP:0000704)1.59556434
150Chest pain (HP:0100749)1.59038387
151Scanning speech (HP:0002168)1.58112664
152Prolonged bleeding time (HP:0003010)1.58056404
153Scapular winging (HP:0003691)1.57925265
154Recurrent fungal infections (HP:0002841)1.57536663
155Type 1 muscle fiber predominance (HP:0003803)1.56533080
156Entropion (HP:0000621)1.56523372
157Disinhibition (HP:0000734)1.56382410
158Vertebral arch anomaly (HP:0008438)1.56363536
159Hemiplegia (HP:0002301)1.56190460
160Stereotypic behavior (HP:0000733)1.56129346
161Thickened helices (HP:0000391)1.55997404
162Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55976585
163Open mouth (HP:0000194)1.55363344
164Recurrent gram-negative bacterial infections (HP:0005420)1.54772243
165Pulmonic stenosis (HP:0001642)1.54711960
166Aplasia involving bones of the upper limbs (HP:0009823)1.54144575
167Aplasia of the phalanges of the hand (HP:0009802)1.54144575
168Aplasia involving bones of the extremities (HP:0009825)1.54144575
169Optic neuritis (HP:0100653)1.54086166
170Retrobulbar optic neuritis (HP:0100654)1.54086166
171Abnormality of oral frenula (HP:0000190)1.53606454
172Enlarged penis (HP:0000040)1.53137106
173Tibial bowing (HP:0002982)1.52063427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.40703404
2FGFR22.29563894
3BRD42.26511301
4SGK22.13091247
5CASK2.08020283
6CAMK1G1.98323368
7NEK91.88213204
8EPHA31.87009552
9MAP3K101.86598145
10NUAK11.84650414
11SGK31.84542901
12LATS11.83696737
13NLK1.83169141
14SGK4941.82474262
15SGK2231.82474262
16MAP3K41.81105208
17CDK121.80562524
18TTN1.77786843
19WNK11.76856415
20MAP2K31.73954831
21STK391.66767191
22FGFR31.61673168
23YES11.58785227
24MARK11.55713194
25AKT31.55341471
26STK241.54868830
27TNIK1.52986082
28MAP3K61.52274817
29DMPK1.43317406
30CAMK1D1.42113815
31NTRK31.41550515
32PTK61.37551742
33BLK1.32945413
34IRAK41.32397850
35TYK21.30376171
36ERBB31.29389586
37CSK1.28178473
38MAP4K11.24183623
39PKN11.22058637
40ZAP701.20679342
41KSR21.20558413
42STK31.18283480
43MAP3K131.17849848
44INSRR1.17248809
45SIK31.17228959
46PHKG11.16879579
47PHKG21.16879579
48JAK11.15668217
49EPHB11.15552811
50IKBKE1.14731106
51FER1.13622040
52MAP2K71.12332806
53EPHA41.09573783
54HCK1.07261434
55MST1R1.04909055
56WNK41.04351859
57MAP3K11.03814798
58PDGFRA1.03654721
59IRAK11.03083690
60MAP3K121.03016883
61FGFR41.01762275
62PRKCH1.00062688
63JAK30.99573861
64SGK10.99135132
65PAK60.97417065
66JAK20.96254490
67PDGFRB0.94615966
68NTRK20.91760405
69PAK30.91573345
70EEF2K0.91567115
71OXSR10.90953089
72MAPK70.90437720
73PRKCQ0.89429353
74BTK0.89215921
75LMTK20.87992280
76PIK3CA0.87053693
77PNCK0.86017451
78CDK60.85783248
79SIK20.85730193
80PLK20.82481765
81MARK30.82027314
82TEC0.81976920
83STK110.81657961
84MAP2K40.81656650
85FES0.80675131
86RET0.80239207
87PRKAA20.79987358
88SIK10.78745665
89MELK0.78279394
90SYK0.78194851
91CSNK1A1L0.78071739
92PRKCE0.77182872
93HIPK20.77124311
94MAPK130.77122000
95RIPK10.75546261
96MAP3K30.74061825
97CDK90.73335147
98STK38L0.72552983
99OBSCN0.72486186
100TRPM70.71735758
101CDK50.70802306
102TNK20.70786311
103RAF10.70626415
104TRIB30.70532996
105IRAK20.70356085
106GRK10.67121419
107NEK60.67072100
108PRKD10.65543472
109CHUK0.64986537
110CAMKK10.64624732
111MAP3K20.64470984
112PRKAA10.64214052
113CAMKK20.63536271
114GSK3A0.63514412
115RIPK40.62388904
116TGFBR20.61808790
117MARK20.61412821
118MAP3K50.61336212
119CSNK1G20.60810247
120STK380.60797236
121MAP3K140.60350219
122DYRK1A0.59559593
123TXK0.58866275
124MAP3K70.58162893
125ROCK10.57227691
126LCK0.56895569
127CSNK1G10.56460649
128PDPK10.54607970
129DAPK20.53945337
130KSR10.53140211
131PBK0.53136038
132BMPR20.52572028
133MAPK120.52349588
134FYN0.51859584
135PRPF4B0.51805573
136ITK0.51462767
137ROCK20.50768738
138PDK10.50476422
139LYN0.50396407
140CAMK40.49991959
141PIK3CG0.49232155
142MAPK100.49099335
143CLK10.49034383
144CAMK2A0.49007119
145TAOK30.48603014
146RPS6KA20.48026620
147SCYL20.45096779
148MTOR0.44279147
149MAPK40.42273365

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047441.87096367
2Olfactory transduction_Homo sapiens_hsa047401.68343400
3Nicotine addiction_Homo sapiens_hsa050331.64697948
4* Acute myeloid leukemia_Homo sapiens_hsa052211.60600842
5Morphine addiction_Homo sapiens_hsa050321.57817224
6Glutamatergic synapse_Homo sapiens_hsa047241.51814343
7Renin secretion_Homo sapiens_hsa049241.50132917
8GABAergic synapse_Homo sapiens_hsa047271.48015082
9Long-term potentiation_Homo sapiens_hsa047201.47669947
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46033430
11Leishmaniasis_Homo sapiens_hsa051401.44855417
12* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44122761
13* Prolactin signaling pathway_Homo sapiens_hsa049171.37348206
14Axon guidance_Homo sapiens_hsa043601.36659245
15Gastric acid secretion_Homo sapiens_hsa049711.34093605
16Dorso-ventral axis formation_Homo sapiens_hsa043201.31208485
17* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30146078
18Long-term depression_Homo sapiens_hsa047301.30120835
19Dopaminergic synapse_Homo sapiens_hsa047281.29748699
20Salivary secretion_Homo sapiens_hsa049701.29093660
21* Toxoplasmosis_Homo sapiens_hsa051451.27492697
22Circadian entrainment_Homo sapiens_hsa047131.27252503
23* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26482682
24Dilated cardiomyopathy_Homo sapiens_hsa054141.26276352
25* Cholinergic synapse_Homo sapiens_hsa047251.25968362
26* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25624577
27* Measles_Homo sapiens_hsa051621.22096338
28ECM-receptor interaction_Homo sapiens_hsa045121.22089857
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.22036312
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22001236
31Nitrogen metabolism_Homo sapiens_hsa009101.20904132
32* Jak-STAT signaling pathway_Homo sapiens_hsa046301.20567363
33* Hepatitis B_Homo sapiens_hsa051611.19780128
34* TNF signaling pathway_Homo sapiens_hsa046681.19579151
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18598672
36* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16265523
37* Glioma_Homo sapiens_hsa052141.16225217
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16127582
39* Oxytocin signaling pathway_Homo sapiens_hsa049211.15144870
40* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14115650
41* Colorectal cancer_Homo sapiens_hsa052101.13605090
42* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13203659
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12810346
44* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09728216
45Thyroid cancer_Homo sapiens_hsa052161.09578357
46Circadian rhythm_Homo sapiens_hsa047101.09091465
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08430730
48* cAMP signaling pathway_Homo sapiens_hsa040241.08305952
49* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07666691
50Malaria_Homo sapiens_hsa051441.07490949
51Tuberculosis_Homo sapiens_hsa051521.06183283
52* Focal adhesion_Homo sapiens_hsa045101.05415066
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05152416
54Insulin secretion_Homo sapiens_hsa049111.04249801
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04104560
56Serotonergic synapse_Homo sapiens_hsa047261.03921991
57Amphetamine addiction_Homo sapiens_hsa050311.03249981
58Taste transduction_Homo sapiens_hsa047421.03069913
59* Type II diabetes mellitus_Homo sapiens_hsa049301.02287289
60GnRH signaling pathway_Homo sapiens_hsa049121.00891188
61* Influenza A_Homo sapiens_hsa051641.00410058
62* Leukocyte transendothelial migration_Homo sapiens_hsa046701.00300471
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99613853
64* Endometrial cancer_Homo sapiens_hsa052130.99012436
65* ErbB signaling pathway_Homo sapiens_hsa040120.97297644
66* Hepatitis C_Homo sapiens_hsa051600.96940971
67* Phospholipase D signaling pathway_Homo sapiens_hsa040720.95419132
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.95094832
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91991418
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91825641
71Calcium signaling pathway_Homo sapiens_hsa040200.91020288
72* Choline metabolism in cancer_Homo sapiens_hsa052310.90635967
73* Renal cell carcinoma_Homo sapiens_hsa052110.90416044
74* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88005293
75Melanogenesis_Homo sapiens_hsa049160.87868321
76* Estrogen signaling pathway_Homo sapiens_hsa049150.86785307
77Gap junction_Homo sapiens_hsa045400.86416543
78* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84944438
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84645315
80Cocaine addiction_Homo sapiens_hsa050300.83138808
81Synaptic vesicle cycle_Homo sapiens_hsa047210.82595770
82* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81746377
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81413008
84* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80843307
85MAPK signaling pathway_Homo sapiens_hsa040100.78420941
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.77821231
87* Ras signaling pathway_Homo sapiens_hsa040140.77088959
88* Prostate cancer_Homo sapiens_hsa052150.76162071
89* Pancreatic cancer_Homo sapiens_hsa052120.75573154
90* Rap1 signaling pathway_Homo sapiens_hsa040150.74926612
91* FoxO signaling pathway_Homo sapiens_hsa040680.74078443
92* Inositol phosphate metabolism_Homo sapiens_hsa005620.73680458
93* Melanoma_Homo sapiens_hsa052180.73369208
94* Proteoglycans in cancer_Homo sapiens_hsa052050.73303948
95Staphylococcus aureus infection_Homo sapiens_hsa051500.73144155
96Adherens junction_Homo sapiens_hsa045200.72822312
97* B cell receptor signaling pathway_Homo sapiens_hsa046620.72378089
98* Non-small cell lung cancer_Homo sapiens_hsa052230.71007712
99Lysine degradation_Homo sapiens_hsa003100.70627502
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70383391
101* Apoptosis_Homo sapiens_hsa042100.70061185
102* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69480166
103Viral myocarditis_Homo sapiens_hsa054160.69138186
104Hematopoietic cell lineage_Homo sapiens_hsa046400.69112157
105* Platelet activation_Homo sapiens_hsa046110.69086532
106* Viral carcinogenesis_Homo sapiens_hsa052030.68729884
107* HIF-1 signaling pathway_Homo sapiens_hsa040660.68665455
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68469941
109* Chronic myeloid leukemia_Homo sapiens_hsa052200.68409568
110Pancreatic secretion_Homo sapiens_hsa049720.67549722
111Herpes simplex infection_Homo sapiens_hsa051680.66994993
112* T cell receptor signaling pathway_Homo sapiens_hsa046600.66826769
113* Amoebiasis_Homo sapiens_hsa051460.66496178
114Ovarian steroidogenesis_Homo sapiens_hsa049130.65756706
115Tight junction_Homo sapiens_hsa045300.65373572
116Shigellosis_Homo sapiens_hsa051310.64858339
117* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64472400
118* Chemokine signaling pathway_Homo sapiens_hsa040620.64342980
119* Pathways in cancer_Homo sapiens_hsa052000.62872564
120* Osteoclast differentiation_Homo sapiens_hsa043800.62202662
121Thyroid hormone synthesis_Homo sapiens_hsa049180.61979195
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61662312
123* Sphingolipid signaling pathway_Homo sapiens_hsa040710.61139156
124* Insulin resistance_Homo sapiens_hsa049310.60906479
125Pertussis_Homo sapiens_hsa051330.60143309
126* HTLV-I infection_Homo sapiens_hsa051660.59953854
127Allograft rejection_Homo sapiens_hsa053300.59754121
128Graft-versus-host disease_Homo sapiens_hsa053320.59563849
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58735801
130* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56740182
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56479343
132Legionellosis_Homo sapiens_hsa051340.56005083
133Endocytosis_Homo sapiens_hsa041440.55547588
134* mTOR signaling pathway_Homo sapiens_hsa041500.55255125
135* Insulin signaling pathway_Homo sapiens_hsa049100.54998188
136* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54955141
137* AMPK signaling pathway_Homo sapiens_hsa041520.53441801
138* MicroRNAs in cancer_Homo sapiens_hsa052060.52359748
139* Neurotrophin signaling pathway_Homo sapiens_hsa047220.51915190
140* VEGF signaling pathway_Homo sapiens_hsa043700.51437672
141* Small cell lung cancer_Homo sapiens_hsa052220.51378381
142Glucagon signaling pathway_Homo sapiens_hsa049220.50393355
143Fatty acid biosynthesis_Homo sapiens_hsa000610.50212489
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50015582
145* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49788708

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