PIK3CD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.88955372
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.13740147
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.13740147
4regulation of gamma-delta T cell differentiation (GO:0045586)5.77305187
5antigen processing and presentation of endogenous antigen (GO:0019883)5.58809044
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.41304333
7negative regulation of cell killing (GO:0031342)5.41304333
8regulation of gamma-delta T cell activation (GO:0046643)5.32815343
9positive thymic T cell selection (GO:0045059)5.26721965
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.12162188
11negative T cell selection (GO:0043383)5.05178199
12negative thymic T cell selection (GO:0045060)5.04068469
13detection of other organism (GO:0098543)4.68365627
14detection of bacterium (GO:0016045)4.59934600
15thymic T cell selection (GO:0045061)4.59420930
16response to interleukin-15 (GO:0070672)4.57733186
17positive T cell selection (GO:0043368)4.52338576
18regulation of B cell receptor signaling pathway (GO:0050855)4.47662653
19positive regulation of B cell differentiation (GO:0045579)4.44426346
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.41688682
21T cell selection (GO:0045058)4.38616197
22interferon-gamma production (GO:0032609)4.26329956
23neutrophil activation involved in immune response (GO:0002283)4.26227103
24macrophage activation involved in immune response (GO:0002281)4.22633072
25leukocyte aggregation (GO:0070486)4.20264465
26* B cell receptor signaling pathway (GO:0050853)4.18845543
27regulation of B cell differentiation (GO:0045577)4.12035759
28response to peptidoglycan (GO:0032494)3.98804601
29cellular response to interleukin-15 (GO:0071350)3.96482961
30tolerance induction (GO:0002507)3.95297754
31negative regulation of leukocyte mediated immunity (GO:0002704)3.92854513
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.90939963
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.86154495
34detection of external biotic stimulus (GO:0098581)3.84359461
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79734304
36* T cell migration (GO:0072678)3.79488902
37regulation of interferon-beta biosynthetic process (GO:0045357)3.77829685
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.64700470
39response to host immune response (GO:0052572)3.64700470
40* antigen receptor-mediated signaling pathway (GO:0050851)3.62572323
41response to muramyl dipeptide (GO:0032495)3.60581349
42neutrophil activation (GO:0042119)3.60214488
43negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58978348
44negative regulation of phagocytosis (GO:0050765)3.56483934
45regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.55269606
46regulation of T cell tolerance induction (GO:0002664)3.54841021
47T cell homeostasis (GO:0043029)3.54506748
48* T cell receptor signaling pathway (GO:0050852)3.52875053
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.45327480
50positive regulation of interleukin-2 production (GO:0032743)3.45230664
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42992537
52T cell costimulation (GO:0031295)3.42018089
53detection of molecule of bacterial origin (GO:0032490)3.41461626
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40231108
55response to host (GO:0075136)3.40231108
56response to host defenses (GO:0052200)3.40231108
57regulation of regulatory T cell differentiation (GO:0045589)3.36512369
58detection of biotic stimulus (GO:0009595)3.35961650
59lymphocyte costimulation (GO:0031294)3.35857402
60JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30867609
61regulation of T cell mediated cytotoxicity (GO:0001914)3.29380573
62microglial cell activation (GO:0001774)3.28557328
63regulation of alpha-beta T cell proliferation (GO:0046640)3.27306017
64defense response to protozoan (GO:0042832)3.25581218
65positive regulation of granulocyte differentiation (GO:0030854)3.25552265
66granulocyte activation (GO:0036230)3.25056167
67NIK/NF-kappaB signaling (GO:0038061)3.23156794
68immunoglobulin mediated immune response (GO:0016064)3.22304430
69regulation of mast cell degranulation (GO:0043304)3.19779660
70* myeloid cell activation involved in immune response (GO:0002275)3.19402451
71positive regulation of T cell mediated cytotoxicity (GO:0001916)3.18423450
72* respiratory burst (GO:0045730)3.18209090
73leukocyte migration involved in inflammatory response (GO:0002523)3.18023369
74positive regulation of isotype switching (GO:0045830)3.17651330
75germinal center formation (GO:0002467)3.17637603
76negative regulation of innate immune response (GO:0045824)3.16939870
77regulation of isotype switching to IgG isotypes (GO:0048302)3.14197849
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10500367
79negative regulation of T-helper cell differentiation (GO:0045623)3.10092260
80negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10092260
81myeloid dendritic cell activation (GO:0001773)3.09774017
82regulation of response to interferon-gamma (GO:0060330)3.07518993
83positive regulation of humoral immune response (GO:0002922)3.07351206
84regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07132079
85regulation of T cell receptor signaling pathway (GO:0050856)3.05921216
86neutrophil mediated immunity (GO:0002446)3.05764104
87negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04438193
88regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.04181999
89regulation of type I interferon-mediated signaling pathway (GO:0060338)3.02647515
90antigen processing and presentation via MHC class Ib (GO:0002475)3.02344421
91leukocyte cell-cell adhesion (GO:0007159)3.02321365
92regulation of interleukin-2 biosynthetic process (GO:0045076)3.01921535
93positive regulation of histone deacetylation (GO:0031065)3.01199438
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.98365051
95macrophage activation (GO:0042116)2.98298504
96regulation of hypersensitivity (GO:0002883)2.97665712
97activated T cell proliferation (GO:0050798)2.96718415
98negative regulation of alpha-beta T cell activation (GO:0046636)2.96157058
99* cellular extravasation (GO:0045123)2.94221933
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.93778613
101positive regulation of tolerance induction (GO:0002645)2.93450229
102* lymphocyte homeostasis (GO:0002260)2.93233051
103positive regulation of mast cell activation (GO:0033005)2.92791456
104regulation of mast cell activation involved in immune response (GO:0033006)2.91952892
105* mast cell activation (GO:0045576)2.88084079
106mature B cell differentiation (GO:0002335)2.86032087
107* immune response-activating cell surface receptor signaling pathway (GO:0002429)2.85228114
108regulation of granulocyte differentiation (GO:0030852)2.83897634
109positive regulation of alpha-beta T cell proliferation (GO:0046641)2.82495951
110myeloid dendritic cell differentiation (GO:0043011)2.81735701
111negative regulation of T cell mediated immunity (GO:0002710)2.81202704
112response to type I interferon (GO:0034340)2.80584280
113T cell proliferation (GO:0042098)2.79750484
114interferon-gamma-mediated signaling pathway (GO:0060333)2.79586770
115negative regulation of erythrocyte differentiation (GO:0045647)2.77368353
116regulation of tolerance induction (GO:0002643)2.76106461
117positive regulation of immunoglobulin mediated immune response (GO:0002891)2.75740621
118positive regulation of B cell mediated immunity (GO:0002714)2.75740621
119regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.74225168
120type I interferon signaling pathway (GO:0060337)2.74011894
121cellular response to type I interferon (GO:0071357)2.74011894
122response to protozoan (GO:0001562)2.73612914
123positive regulation by organism of defense response of other organism involved in symbiotic interact2.73034219
124modulation by symbiont of host immune response (GO:0052553)2.73034219
125positive regulation by symbiont of host defense response (GO:0052509)2.73034219
126modulation by symbiont of host defense response (GO:0052031)2.73034219
127modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73034219
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73034219
129negative regulation of interleukin-12 production (GO:0032695)2.71661351
130positive regulation of immunoglobulin production (GO:0002639)2.68479727
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68424683
132regulation of interleukin-2 production (GO:0032663)2.68283353
133positive regulation of T cell differentiation (GO:0045582)2.68090626
134positive regulation of B cell activation (GO:0050871)2.67766321
135regulation of natural killer cell mediated immunity (GO:0002715)2.67328189
136regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.67328189
137positive regulation of DNA recombination (GO:0045911)2.66219979
138negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.63751452
139* natural killer cell activation (GO:0030101)2.61737504
140B cell mediated immunity (GO:0019724)2.61720847
141positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61638879
142regulation of B cell mediated immunity (GO:0002712)2.61286535
143regulation of alpha-beta T cell activation (GO:0046634)2.59537401

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.24443978
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.80553371
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.57018104
4MYC_22102868_ChIP-Seq_BL_Human4.23126672
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.95513438
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.39510696
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34032269
8* VDR_21846776_ChIP-Seq_THP-1_Human3.08219458
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.07095353
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.04687442
11* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.97629216
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.88858914
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.85180148
14RUNX_20019798_ChIP-Seq_JUKART_Human2.84768893
15MYB_26560356_Chip-Seq_TH2_Human2.84563400
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.71901684
17* MAF_26560356_Chip-Seq_TH1_Human2.69094152
18SCL_19346495_ChIP-Seq_HPC-7_Human2.63593913
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63308834
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55953549
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55060035
22UTX_26944678_Chip-Seq_JUKART_Human2.52321824
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.52174503
24* MYB_26560356_Chip-Seq_TH1_Human2.50910415
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43808960
26* IRF8_27001747_Chip-Seq_BMDM_Mouse2.41275530
27TCF7_22412390_ChIP-Seq_EML_Mouse2.38844392
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35968821
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31596925
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28860482
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27881179
32VDR_24763502_ChIP-Seq_THP-1_Human2.22430850
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.13390722
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10707307
35* SPI1_23547873_ChIP-Seq_NB4_Human2.10021964
36* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05406153
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99963659
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95950379
39* KDM2B_26808549_Chip-Seq_DND41_Human1.85139635
40* MAF_26560356_Chip-Seq_TH2_Human1.81024582
41* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79916703
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69518783
43CIITA_25753668_ChIP-Seq_RAJI_Human1.68822262
44* SPI1_23127762_ChIP-Seq_K562_Human1.67149532
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66034375
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64687457
47GATA3_27048872_Chip-Seq_THYMUS_Human1.63747978
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61438240
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60010460
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.56707053
51* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54774857
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.52841920
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49975928
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49831049
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42383384
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.42068005
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39063104
58* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38844588
59* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32060266
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.30204734
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29681182
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26730760
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26514823
64PU_27001747_Chip-Seq_BMDM_Mouse1.26008497
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23840239
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23620000
67GATA1_22025678_ChIP-Seq_K562_Human1.23060399
68* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22161922
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21666388
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18828271
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15896562
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15205287
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15065973
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13644265
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12801178
76* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08946812
77GATA3_26560356_Chip-Seq_TH2_Human1.08203816
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06605016
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05508820
80* BCL6_27268052_Chip-Seq_Bcells_Human1.05273689
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04993107
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04774445
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03481378
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03389106
85NCOR1_26117541_ChIP-Seq_K562_Human1.02156854
86* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01731995
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00955165
88BCOR_27268052_Chip-Seq_Bcells_Human1.00092313
89CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97299920
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94889478
91FOXP3_21729870_ChIP-Seq_TREG_Human0.93184900
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92473587
93VDR_23849224_ChIP-Seq_CD4+_Human0.90372489
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89011387
95* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88720060
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88643610
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88048106
98* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86502818
99E2F1_21310950_ChIP-Seq_MCF-7_Human0.85750198
100* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83980587
101GATA2_19941826_ChIP-Seq_K562_Human0.83086491
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82220738
103CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81757866
104KDM5A_27292631_Chip-Seq_BREAST_Human0.81411685
105ETS1_22383799_ChIP-Seq_G1ME_Mouse0.81204669
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80387364
107LXR_22292898_ChIP-Seq_THP-1_Human0.76037236
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74332642
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73039329
110GATA1_19941826_ChIP-Seq_K562_Human0.71666284
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.69610436
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69348391
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68765562
114VDR_24787735_ChIP-Seq_THP-1_Human0.68419837
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67616314

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.80090335
2MP0001835_abnormal_antigen_presentation3.74845163
3MP0000685_abnormal_immune_system3.54013170
4* MP0001800_abnormal_humoral_immune3.45854167
5MP0005671_abnormal_response_to3.35402815
6MP0001790_abnormal_immune_system3.22491283
7MP0005387_immune_system_phenotype3.22491283
8MP0002396_abnormal_hematopoietic_system2.95113561
9MP0003303_peritoneal_inflammation2.90370762
10* MP0002452_abnormal_antigen_presenting2.90165000
11* MP0002398_abnormal_bone_marrow2.85143566
12* MP0002420_abnormal_adaptive_immunity2.83162028
13* MP0005000_abnormal_immune_tolerance2.82717904
14* MP0002723_abnormal_immune_serum2.81155402
15* MP0001819_abnormal_immune_cell2.80045760
16MP0009785_altered_susceptibility_to2.51774130
17* MP0000716_abnormal_immune_system2.46697790
18* MP0003436_decreased_susceptibility_to2.45255296
19MP0005025_abnormal_response_to2.43297021
20MP0004808_abnormal_hematopoietic_stem2.40335409
21* MP0000689_abnormal_spleen_morphology2.33404700
22MP0002405_respiratory_system_inflammati2.33206914
23MP0003300_gastrointestinal_ulcer2.32708696
24* MP0002722_abnormal_immune_system2.29482024
25* MP0000703_abnormal_thymus_morphology2.25830948
26* MP0002419_abnormal_innate_immunity2.19788018
27MP0009333_abnormal_splenocyte_physiolog2.18907658
28MP0002166_altered_tumor_susceptibility2.16418493
29MP0002148_abnormal_hypersensitivity_rea2.10474952
30* MP0002429_abnormal_blood_cell2.07127977
31MP0001873_stomach_inflammation2.06201794
32* MP0005464_abnormal_platelet_physiology1.97709659
33* MP0010155_abnormal_intestine_physiology1.95002736
34MP0006082_CNS_inflammation1.90046953
35MP0004510_myositis1.88207847
36MP0003866_abnormal_defecation1.87277870
37MP0004947_skin_inflammation1.84176306
38MP0002006_tumorigenesis1.81052320
39MP0009278_abnormal_bone_marrow1.78403847
40MP0008260_abnormal_autophagy1.72215125
41* MP0001845_abnormal_inflammatory_respons1.70881311
42MP0001545_abnormal_hematopoietic_system1.68368300
43MP0005397_hematopoietic_system_phenotyp1.68368300
44MP0004381_abnormal_hair_follicle1.65380809
45MP0000465_gastrointestinal_hemorrhage1.65054353
46MP0003724_increased_susceptibility_to1.59383914
47MP0001853_heart_inflammation1.51836391
48MP0005310_abnormal_salivary_gland1.51396700
49MP0003077_abnormal_cell_cycle1.32068195
50MP0002933_joint_inflammation1.28368184
51MP0010094_abnormal_chromosome_stability1.27077785
52MP0010352_gastrointestinal_tract_polyps1.26576338
53* MP0000490_abnormal_crypts_of1.26363201
54MP0008057_abnormal_DNA_replication1.26028267
55MP0002019_abnormal_tumor_incidence1.25653159
56MP0010307_abnormal_tumor_latency1.24551980
57MP0000858_altered_metastatic_potential1.19733830
58MP0003693_abnormal_embryo_hatching1.18857250
59MP0004883_abnormal_blood_vessel1.14310623
60MP0005174_abnormal_tail_pigmentation1.13904563
61MP0002277_abnormal_respiratory_mucosa1.11944448
62MP0008469_abnormal_protein_level1.10368452
63MP0003448_altered_tumor_morphology1.08367677
64* MP0001533_abnormal_skeleton_physiology1.06243444
65MP0005076_abnormal_cell_differentiation1.06240840
66MP0008961_abnormal_basal_metabolism1.05569173
67MP0001851_eye_inflammation1.04871682
68MP0003111_abnormal_nucleus_morphology1.03032513
69MP0002009_preneoplasia0.89792806
70MP0005058_abnormal_lysosome_morphology0.82271330
71MP0005075_abnormal_melanosome_morpholog0.81139406
72MP0003172_abnormal_lysosome_physiology0.80419017
73MP0003075_altered_response_to0.80252403
74MP0001986_abnormal_taste_sensitivity0.80040151
75MP0008007_abnormal_cellular_replicative0.76672590
76MP0005164_abnormal_response_to0.76670370
77MP0002132_abnormal_respiratory_system0.75916057
78MP0004957_abnormal_blastocyst_morpholog0.73646499
79MP0003045_fibrosis0.73443727
80MP0000313_abnormal_cell_death0.73341160
81MP0003690_abnormal_glial_cell0.71326892
82MP0002998_abnormal_bone_remodeling0.71025239
83MP0003656_abnormal_erythrocyte_physiolo0.71008145
84MP0003566_abnormal_cell_adhesion0.68667177
85MP0000350_abnormal_cell_proliferation0.68617223
86MP0005023_abnormal_wound_healing0.67990170
87MP0005166_decreased_susceptibility_to0.67012941
88MP0003191_abnormal_cellular_cholesterol0.66740218
89MP0008058_abnormal_DNA_repair0.66370633
90MP0000604_amyloidosis0.65705856
91* MP0005390_skeleton_phenotype0.65290393
92MP0003828_pulmonary_edema0.65196226
93MP0009763_increased_sensitivity_to0.64047033
94MP0009765_abnormal_xenobiotic_induced0.63436804
95MP0003795_abnormal_bone_structure0.60857173
96MP0001663_abnormal_digestive_system0.60690619
97MP0000569_abnormal_digit_pigmentation0.60370222
98MP0000015_abnormal_ear_pigmentation0.60249087
99MP0008877_abnormal_DNA_methylation0.60235583
100MP0003091_abnormal_cell_migration0.59922280
101MP0000249_abnormal_blood_vessel0.58757035
102MP0004130_abnormal_muscle_cell0.58483326
103MP0002138_abnormal_hepatobiliary_system0.57720524
104MP0008874_decreased_physiological_sensi0.55678510
105MP0002928_abnormal_bile_duct0.55341897
106MP0005451_abnormal_body_composition0.55289353
107MP0001730_embryonic_growth_arrest0.55100023
108MP0003787_abnormal_imprinting0.54899890
109MP0009840_abnormal_foam_cell0.54878837
110MP0002693_abnormal_pancreas_physiology0.54558276
111MP0008873_increased_physiological_sensi0.54350395
112MP0009764_decreased_sensitivity_to0.52661559
113MP0003221_abnormal_cardiomyocyte_apopto0.52598867
114MP0005621_abnormal_cell_physiology0.52116476
115MP0003183_abnormal_peptide_metabolism0.51768412
116MP0002095_abnormal_skin_pigmentation0.51031159
117MP0000343_altered_response_to0.50745740
118* MP0000477_abnormal_intestine_morphology0.50302887
119MP0004185_abnormal_adipocyte_glucose0.50074890
120MP0001348_abnormal_lacrimal_gland0.49866995
121MP0002136_abnormal_kidney_physiology0.49713918
122MP0008004_abnormal_stomach_pH0.49002896
123MP0000609_abnormal_liver_physiology0.44656784
124MP0005381_digestive/alimentary_phenotyp0.43933728
125MP0000371_diluted_coat_color0.43206547
126MP0009115_abnormal_fat_cell0.38534845

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)4.93377802
2Chronic otitis media (HP:0000389)4.73403587
3IgM deficiency (HP:0002850)4.71638486
4Recurrent viral infections (HP:0004429)4.67718752
5Recurrent bronchitis (HP:0002837)4.61172098
6T lymphocytopenia (HP:0005403)4.49166897
7Panhypogammaglobulinemia (HP:0003139)4.42751413
8Recurrent fungal infections (HP:0002841)4.33375556
9Recurrent abscess formation (HP:0002722)4.30509997
10Abnormality of T cell number (HP:0011839)4.25618449
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.19254474
12Gastrointestinal infarctions (HP:0005244)4.15147488
13Eczematoid dermatitis (HP:0000976)4.14660651
14* Cellulitis (HP:0100658)4.13701332
15Nasal polyposis (HP:0100582)4.09282246
16Recurrent bacterial skin infections (HP:0005406)3.97035429
17Abnormality of the fingertips (HP:0001211)3.96131958
18Meningitis (HP:0001287)3.93303898
19Verrucae (HP:0200043)3.92382110
20Papilloma (HP:0012740)3.92382110
21Abnormality of T cells (HP:0002843)3.80700210
22Elevated erythrocyte sedimentation rate (HP:0003565)3.65331609
23Myositis (HP:0100614)3.60400504
24Pustule (HP:0200039)3.60195916
25Inflammation of the large intestine (HP:0002037)3.58502427
26Gastrointestinal inflammation (HP:0004386)3.57481868
27Abnormality of the nasal mucosa (HP:0000433)3.48621384
28Recurrent cutaneous fungal infections (HP:0011370)3.44015498
29Chronic mucocutaneous candidiasis (HP:0002728)3.44015498
30Thyroiditis (HP:0100646)3.39447329
31Spontaneous hematomas (HP:0007420)3.36808576
32Colitis (HP:0002583)3.31769903
33Keratoconjunctivitis (HP:0001096)3.24409284
34Autoimmune thrombocytopenia (HP:0001973)3.24368879
35Urticaria (HP:0001025)3.22686782
36Lymphopenia (HP:0001888)3.14055472
37Abnormality of B cell number (HP:0010975)3.13785677
38B lymphocytopenia (HP:0010976)3.13785677
39Recurrent skin infections (HP:0001581)3.10158682
40Stomatitis (HP:0010280)3.06889372
41Abnormality of T cell physiology (HP:0011840)3.06690698
42Combined immunodeficiency (HP:0005387)3.04723653
43Severe combined immunodeficiency (HP:0004430)3.02719693
44Abnormality of cells of the lymphoid lineage (HP:0012140)3.02400132
45Chronic sinusitis (HP:0011109)3.01333613
46Mediastinal lymphadenopathy (HP:0100721)3.00182635
47Hypochromic anemia (HP:0001931)2.97432250
48Thrombocytosis (HP:0001894)2.91672941
49Vasculitis (HP:0002633)2.91496592
50Obstructive lung disease (HP:0006536)2.89636230
51Chronic obstructive pulmonary disease (HP:0006510)2.89636230
52Osteomyelitis (HP:0002754)2.89164606
53Hypochromic microcytic anemia (HP:0004840)2.88007962
54Prolonged bleeding time (HP:0003010)2.87351567
55Increased IgM level (HP:0003496)2.80874368
56Increased IgE level (HP:0003212)2.80512039
57IgG deficiency (HP:0004315)2.77922263
58Recurrent sinusitis (HP:0011108)2.76844800
59Petechiae (HP:0000967)2.72044399
60Eosinophilia (HP:0001880)2.67117561
61Bronchitis (HP:0012387)2.66324467
62Episodic fever (HP:0001954)2.60381277
63Optic neuritis (HP:0100653)2.57660350
64Retrobulbar optic neuritis (HP:0100654)2.57660350
65Leukocytosis (HP:0001974)2.55791020
66Encephalitis (HP:0002383)2.55183720
67Abnormality of eosinophils (HP:0001879)2.53891406
68Anorexia (HP:0002039)2.53480289
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46152456
70Increased density of long bones (HP:0006392)2.41701173
71IgA deficiency (HP:0002720)2.41451873
72Orchitis (HP:0100796)2.40773579
73Granulocytopenia (HP:0001913)2.38899710
74Sepsis (HP:0100806)2.35970320
75Abnormality of the pleura (HP:0002103)2.35481473
76Gastrointestinal stroma tumor (HP:0100723)2.34342425
77Viral hepatitis (HP:0006562)2.33400566
78Lymphoma (HP:0002665)2.33188587
79Epistaxis (HP:0000421)2.29264674
80Abnormal platelet volume (HP:0011876)2.29233159
81Microcytic anemia (HP:0001935)2.29101248
82Pulmonary infiltrates (HP:0002113)2.28031483
83Arterial thrombosis (HP:0004420)2.24818319
84Recurrent gram-negative bacterial infections (HP:0005420)2.21713665
85Chronic diarrhea (HP:0002028)2.20605734
86Slow saccadic eye movements (HP:0000514)2.20306315
87Emphysema (HP:0002097)2.19849787
88Skin ulcer (HP:0200042)2.18809490
89Gangrene (HP:0100758)2.17859317
90Recurrent pneumonia (HP:0006532)2.17201752
91Hemoptysis (HP:0002105)2.17117451
92Recurrent otitis media (HP:0000403)2.17116613
93Basal cell carcinoma (HP:0002671)2.16502113
94Chest pain (HP:0100749)2.15767112
95Interstitial pulmonary disease (HP:0006530)2.15292431
96Periodontitis (HP:0000704)2.13199999
97Abnormality of macrophages (HP:0004311)2.09528889
98Peritonitis (HP:0002586)2.09422106
99Glomerulopathy (HP:0100820)2.08994228
100Abnormality of the peritoneum (HP:0002585)2.07928296
101Recurrent lower respiratory tract infections (HP:0002783)2.07257692
102Restrictive lung disease (HP:0002091)2.06954276
103Papilledema (HP:0001085)2.05040174
104Autoimmune hemolytic anemia (HP:0001890)2.04651413
105Impaired platelet aggregation (HP:0003540)2.03063860
106Abnormal platelet function (HP:0011869)2.03063860
107Acute hepatic failure (HP:0006554)2.01113927
108Gingival bleeding (HP:0000225)1.99615421
109Premature loss of primary teeth (HP:0006323)1.99449423
110Abnormality of the prostate (HP:0008775)1.96975911
111Abnormality of the endocardium (HP:0004306)1.94304384
112Keratitis (HP:0000491)1.93643098
113Gingivitis (HP:0000230)1.91524543
114Keratoconjunctivitis sicca (HP:0001097)1.89880110
115Acute myeloid leukemia (HP:0004808)1.88983867
116Purpura (HP:0000979)1.86851238
117Hematochezia (HP:0002573)1.85164691
118Fatigue (HP:0012378)1.84723240
119Abnormality of the intervertebral disk (HP:0005108)1.80096728
120Joint swelling (HP:0001386)1.79975705
121Skin rash (HP:0000988)1.78732593
122Cheilitis (HP:0100825)1.77567616
123Pulmonary embolism (HP:0002204)1.76528812
124Hypergammaglobulinemia (HP:0010702)1.75252014

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.55622015
2EEF2K4.77637927
3MAP3K103.65903901
4PRPF4B3.01626667
5TXK2.92243087
6STK102.66374242
7GRK62.52656114
8JAK32.52463197
9TYK22.47399467
10ZAP702.31959813
11ITK2.15253865
12BTK2.12500751
13BLK2.00955728
14SYK1.83776286
15IKBKE1.81167972
16PKN21.78324816
17FGFR41.72756306
18MAP3K141.70496601
19JAK11.69868848
20SIK21.64973991
21HCK1.60255718
22TBK11.50275343
23TRIB31.49104852
24TEC1.48875157
25LCK1.48135506
26CSF1R1.44720396
27FGFR31.43803253
28CLK11.43472920
29CDK121.41043813
30FES1.40464937
31NLK1.36796850
32RIPK41.36511339
33MAP3K131.35972074
34PIM11.34269726
35ERN11.29779026
36FGR1.29653751
37KIT1.29567639
38LRRK21.28726043
39SMG11.26269200
40MAP3K31.25814928
41CSK1.23271036
42IKBKB1.17186715
43TGFBR21.13871358
44MARK31.12546784
45IRAK41.10976718
46NEK21.10421587
47MAP3K11.05838828
48EPHB11.04580704
49LYN1.02466327
50KSR20.98722335
51CDK40.98081568
52TAOK30.97509587
53RPS6KA40.97170001
54YES10.91359509
55JAK20.90547711
56TNK20.86413025
57CHUK0.86356333
58PRKCH0.83790204
59BMPR20.83238903
60MAP2K30.81072788
61RPS6KB20.80096824
62STK40.77811209
63IRAK10.77070578
64CAMKK10.75958760
65TAOK10.72549006
66MATK0.71336291
67HIPK20.71260640
68TAOK20.71130196
69TRPM70.70268461
70CDC42BPA0.69696169
71PRKCQ0.67397819
72ALK0.66660977
73MAP3K70.66640150
74MAPK70.66022210
75CAMKK20.65566260
76CDC70.64519177
77CDK190.62433099
78MST40.61395959
79MAPK110.60664385
80FYN0.58230682
81SIK10.57693666
82PDPK10.56854244
83MAP3K80.55888595
84MELK0.55795939
85IRAK20.55079957
86PDK10.54208709
87CDK90.54108492
88MAPKAPK30.54085472
89NME20.53465832
90PRKD20.52605387
91PIK3CG0.52514819
92FLT30.52514633
93MAPK120.51446980
94MARK20.51280113
95TESK20.50847545
96IRAK30.49816011
97STK110.49414000
98EPHA30.49308320
99MAPK40.48947374
100NEK90.45609845
101CDK60.45571485
102RPS6KC10.45138578
103RPS6KL10.45138578
104STK240.44966236
105PTK2B0.44952031
106PTK60.43104526
107MAP3K60.42644128
108PASK0.41891686
109MAP2K20.41126779
110DMPK0.39748944
111TTN0.39486633
112SIK30.39185971
113DYRK1B0.38671402
114TGFBR10.37369276
115MAPKAPK20.37291073
116PDGFRB0.37280329
117MAP3K50.34487079
118BRD40.33612844
119SGK30.32532995
120RPS6KA60.31969389
121SGK20.31864580
122MAP3K20.31167375
123RAF10.30347284
124ATR0.30114583
125ABL10.29008839
126SCYL20.28532104
127MAP3K110.26208363
128RPS6KA10.24580507
129MAPK30.23086851
130RET0.22420815
131EGFR0.21966657
132RPS6KA50.21645151

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.61018819
2* B cell receptor signaling pathway_Homo sapiens_hsa046622.96599402
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.55205264
4* T cell receptor signaling pathway_Homo sapiens_hsa046602.50465243
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.42737831
6* Osteoclast differentiation_Homo sapiens_hsa043802.37596879
7Leishmaniasis_Homo sapiens_hsa051402.36930848
8* Measles_Homo sapiens_hsa051622.32121486
9* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.31987623
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.20875292
11Antigen processing and presentation_Homo sapiens_hsa046122.17360224
12* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.91176468
13Hematopoietic cell lineage_Homo sapiens_hsa046401.85352170
14* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79664044
15* Jak-STAT signaling pathway_Homo sapiens_hsa046301.70760950
16Herpes simplex infection_Homo sapiens_hsa051681.69053262
17* Chemokine signaling pathway_Homo sapiens_hsa040621.48101795
18* Acute myeloid leukemia_Homo sapiens_hsa052211.47728890
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46257214
20Graft-versus-host disease_Homo sapiens_hsa053321.43513147
21* Hepatitis B_Homo sapiens_hsa051611.40523595
22* Chronic myeloid leukemia_Homo sapiens_hsa052201.39317179
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38090870
24* Toxoplasmosis_Homo sapiens_hsa051451.37736052
25Shigellosis_Homo sapiens_hsa051311.37244093
26* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37191868
27Staphylococcus aureus infection_Homo sapiens_hsa051501.32906310
28Allograft rejection_Homo sapiens_hsa053301.32831639
29* Influenza A_Homo sapiens_hsa051641.28554037
30Viral myocarditis_Homo sapiens_hsa054161.27276323
31* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24585079
32DNA replication_Homo sapiens_hsa030301.24136493
33Non-homologous end-joining_Homo sapiens_hsa034501.23819384
34* Leukocyte transendothelial migration_Homo sapiens_hsa046701.23116927
35Tuberculosis_Homo sapiens_hsa051521.22979580
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19980910
37* Pancreatic cancer_Homo sapiens_hsa052121.19750865
38* Apoptosis_Homo sapiens_hsa042101.17788640
39* Platelet activation_Homo sapiens_hsa046111.17511970
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10542562
41Phagosome_Homo sapiens_hsa041451.09723981
42Legionellosis_Homo sapiens_hsa051341.08927417
43* HTLV-I infection_Homo sapiens_hsa051661.08510374
44Base excision repair_Homo sapiens_hsa034101.07837833
45* TNF signaling pathway_Homo sapiens_hsa046681.07244302
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04426215
47* Epstein-Barr virus infection_Homo sapiens_hsa051691.04340129
48Pertussis_Homo sapiens_hsa051331.03297982
49African trypanosomiasis_Homo sapiens_hsa051431.02559561
50Rheumatoid arthritis_Homo sapiens_hsa053230.98765173
51Asthma_Homo sapiens_hsa053100.98154323
52* Viral carcinogenesis_Homo sapiens_hsa052030.97507522
53* Non-small cell lung cancer_Homo sapiens_hsa052230.94526365
54* Neurotrophin signaling pathway_Homo sapiens_hsa047220.94444311
55Mismatch repair_Homo sapiens_hsa034300.91482675
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90818065
57* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90518316
58Malaria_Homo sapiens_hsa051440.89824500
59* Colorectal cancer_Homo sapiens_hsa052100.88297948
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87328406
61* Prolactin signaling pathway_Homo sapiens_hsa049170.86813786
62Salmonella infection_Homo sapiens_hsa051320.86791452
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82897179
64Cell cycle_Homo sapiens_hsa041100.82699643
65* VEGF signaling pathway_Homo sapiens_hsa043700.81107142
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80949857
67Spliceosome_Homo sapiens_hsa030400.80232455
68p53 signaling pathway_Homo sapiens_hsa041150.77019068
69* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75694094
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75516151
71Autoimmune thyroid disease_Homo sapiens_hsa053200.74149582
72* Hepatitis C_Homo sapiens_hsa051600.72851412
73Notch signaling pathway_Homo sapiens_hsa043300.71319733
74RNA degradation_Homo sapiens_hsa030180.70008498
75Ribosome_Homo sapiens_hsa030100.68678011
76* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67596687
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67091683
78Other glycan degradation_Homo sapiens_hsa005110.65767429
79MicroRNAs in cancer_Homo sapiens_hsa052060.65687740
80Endocytosis_Homo sapiens_hsa041440.64275607
81* FoxO signaling pathway_Homo sapiens_hsa040680.59503604
82Homologous recombination_Homo sapiens_hsa034400.58818230
83* Small cell lung cancer_Homo sapiens_hsa052220.58636311
84MAPK signaling pathway_Homo sapiens_hsa040100.58632298
85Dorso-ventral axis formation_Homo sapiens_hsa043200.57954246
86GnRH signaling pathway_Homo sapiens_hsa049120.57424718
87mRNA surveillance pathway_Homo sapiens_hsa030150.53542418
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53239100
89* mTOR signaling pathway_Homo sapiens_hsa041500.52681437
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.52043309
91* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51638461
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51453391
93Type I diabetes mellitus_Homo sapiens_hsa049400.50421727
94* HIF-1 signaling pathway_Homo sapiens_hsa040660.49826191
95* Inositol phosphate metabolism_Homo sapiens_hsa005620.45564985
96RNA transport_Homo sapiens_hsa030130.45491300
97* Sphingolipid signaling pathway_Homo sapiens_hsa040710.43169277
98* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42509575
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.42148916
100* Insulin resistance_Homo sapiens_hsa049310.41907089
101* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41008035
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.39908501
103* Renal cell carcinoma_Homo sapiens_hsa052110.39352652
104* Phospholipase D signaling pathway_Homo sapiens_hsa040720.38130338
105* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37392713
106Lysine degradation_Homo sapiens_hsa003100.37287506
107Fanconi anemia pathway_Homo sapiens_hsa034600.36432523
108Regulation of autophagy_Homo sapiens_hsa041400.36177025
109Long-term potentiation_Homo sapiens_hsa047200.35381539
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34363916
111Thyroid cancer_Homo sapiens_hsa052160.33811938
112* Prostate cancer_Homo sapiens_hsa052150.33295085
113* Rap1 signaling pathway_Homo sapiens_hsa040150.32979205
114* Pathways in cancer_Homo sapiens_hsa052000.32817454
115* ErbB signaling pathway_Homo sapiens_hsa040120.32148884
116* Choline metabolism in cancer_Homo sapiens_hsa052310.31986298
117Lysosome_Homo sapiens_hsa041420.30648423
118* Endometrial cancer_Homo sapiens_hsa052130.29294382
119Systemic lupus erythematosus_Homo sapiens_hsa053220.28364017
120* Ras signaling pathway_Homo sapiens_hsa040140.25311073
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23088489

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