PIK3CG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.57668554
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.38263399
3positive regulation of B cell differentiation (GO:0045579)4.93160501
4regulation of B cell receptor signaling pathway (GO:0050855)4.59679526
5regulation of B cell differentiation (GO:0045577)4.54292532
6positive regulation by symbiont of host defense response (GO:0052509)4.49580118
7modulation by symbiont of host defense response (GO:0052031)4.49580118
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.49580118
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.49580118
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.49580118
11modulation by symbiont of host immune response (GO:0052553)4.49580118
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24765300
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24765300
14neutrophil activation involved in immune response (GO:0002283)4.20259445
15immunoglobulin mediated immune response (GO:0016064)4.16099390
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.14279876
17antigen processing and presentation of endogenous antigen (GO:0019883)4.13082634
18regulation of interferon-beta biosynthetic process (GO:0045357)4.12831619
19detection of other organism (GO:0098543)4.07777535
20positive regulation of granulocyte differentiation (GO:0030854)4.03273614
21regulation of gamma-delta T cell differentiation (GO:0045586)4.00827559
22positive thymic T cell selection (GO:0045059)3.97447770
23B cell receptor signaling pathway (GO:0050853)3.93964375
24detection of molecule of bacterial origin (GO:0032490)3.93210632
25negative regulation of T cell mediated immunity (GO:0002710)3.89466119
26response to peptidoglycan (GO:0032494)3.81147280
27regulation of gamma-delta T cell activation (GO:0046643)3.80411436
28NIK/NF-kappaB signaling (GO:0038061)3.79598349
29leukocyte aggregation (GO:0070486)3.79531748
30germinal center formation (GO:0002467)3.79409073
31positive T cell selection (GO:0043368)3.79098469
32macrophage activation involved in immune response (GO:0002281)3.78069537
33detection of bacterium (GO:0016045)3.74052781
34neutrophil activation (GO:0042119)3.73942997
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72626829
36negative regulation of cell killing (GO:0031342)3.72323050
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.72323050
38detection of external biotic stimulus (GO:0098581)3.67256394
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.66654379
40negative regulation of phagocytosis (GO:0050765)3.63190726
41response to interleukin-15 (GO:0070672)3.62848624
42positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.60699087
43* mast cell activation (GO:0045576)3.59656691
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.55614627
45T cell selection (GO:0045058)3.52347621
46granulocyte activation (GO:0036230)3.48097900
47histone H3-K36 demethylation (GO:0070544)3.46822014
48* myeloid cell activation involved in immune response (GO:0002275)3.43531587
49* respiratory burst (GO:0045730)3.43157187
50negative regulation of T-helper cell differentiation (GO:0045623)3.39321691
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.39321691
52megakaryocyte development (GO:0035855)3.38985872
53detection of biotic stimulus (GO:0009595)3.37938146
54activated T cell proliferation (GO:0050798)3.37779425
55positive regulation of interferon-alpha production (GO:0032727)3.37551110
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.35378926
57Arp2/3 complex-mediated actin nucleation (GO:0034314)3.34659627
58response to muramyl dipeptide (GO:0032495)3.31650051
59B cell mediated immunity (GO:0019724)3.29697817
60cellular response to zinc ion (GO:0071294)3.29048047
61regulation of alpha-beta T cell proliferation (GO:0046640)3.27222393
62regulation of interferon-alpha production (GO:0032647)3.26516922
63negative regulation of leukocyte mediated immunity (GO:0002704)3.25528480
64cellular response to interleukin-15 (GO:0071350)3.24816864
65positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.21555463
66response to host immune response (GO:0052572)3.18345580
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.18345580
68regulation of interleukin-12 biosynthetic process (GO:0045075)3.17242384
69thymic T cell selection (GO:0045061)3.16206750
70production of molecular mediator involved in inflammatory response (GO:0002532)3.15584576
71* cellular extravasation (GO:0045123)3.11092712
72myeloid dendritic cell activation (GO:0001773)3.09754773
73myeloid leukocyte mediated immunity (GO:0002444)3.05247827
74positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04504891
75regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03119913
76defense response to protozoan (GO:0042832)3.02509633
77positive regulation of mast cell degranulation (GO:0043306)3.02250333
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.02250333
79negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01720613
80response to host (GO:0075136)3.00723240
81response to host defenses (GO:0052200)3.00723240
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00723240
83response to protozoan (GO:0001562)3.00677384
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.00389572
85neutrophil mediated immunity (GO:0002446)2.99082935
86negative regulation of granulocyte differentiation (GO:0030853)2.97085762
87regulation of granulocyte differentiation (GO:0030852)2.96726788
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96560531
89mature B cell differentiation (GO:0002335)2.96395200
90regulation of mast cell degranulation (GO:0043304)2.96284211
91microglial cell activation (GO:0001774)2.94120648
92negative regulation of adaptive immune response (GO:0002820)2.92702617
93positive regulation of antigen processing and presentation (GO:0002579)2.91104644
94* mast cell degranulation (GO:0043303)2.90907671
95* mast cell activation involved in immune response (GO:0002279)2.90907671
96regulation of leukocyte degranulation (GO:0043300)2.89861877
97T cell homeostasis (GO:0043029)2.87907049
98negative regulation of interleukin-12 production (GO:0032695)2.87608172
99* myeloid leukocyte activation (GO:0002274)2.87580762
100cellular response to type I interferon (GO:0071357)2.86580671
101type I interferon signaling pathway (GO:0060337)2.86580671
102interferon-gamma production (GO:0032609)2.84603272
103B cell homeostasis (GO:0001782)2.83352441
104regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.83130776
105negative regulation of B cell proliferation (GO:0030889)2.82860037
106* T cell migration (GO:0072678)2.82369963
107tolerance induction (GO:0002507)2.81867934
108antigen processing and presentation via MHC class Ib (GO:0002475)2.81669313
109regulation of tolerance induction (GO:0002643)2.81520112
110positive regulation of B cell activation (GO:0050871)2.81514086
111regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.80367020
112leukocyte cell-cell adhesion (GO:0007159)2.79727564
113lymphocyte homeostasis (GO:0002260)2.77616768
114myeloid dendritic cell differentiation (GO:0043011)2.77572421
115regulation of mast cell activation (GO:0033003)2.76997702
116regulation of erythrocyte differentiation (GO:0045646)2.76025762
117negative thymic T cell selection (GO:0045060)2.75369925
118lymphoid progenitor cell differentiation (GO:0002320)2.75131571
119regulation of RIG-I signaling pathway (GO:0039535)2.75075656
120negative T cell selection (GO:0043383)2.74145724
121* leukocyte degranulation (GO:0043299)2.73889610
122dendritic cell differentiation (GO:0097028)2.73545751
123interferon-gamma-mediated signaling pathway (GO:0060333)2.70681532
124leukocyte homeostasis (GO:0001776)2.69926801
125positive regulation of mast cell activation (GO:0033005)2.68878432
126regulation of mast cell activation involved in immune response (GO:0033006)2.68827081
127definitive hemopoiesis (GO:0060216)2.68551416
128lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68006828
129macrophage activation (GO:0042116)2.63890391
130pinocytosis (GO:0006907)2.63794565
131mature B cell differentiation involved in immune response (GO:0002313)2.63362633
132response to fungus (GO:0009620)2.63349804
133antigen receptor-mediated signaling pathway (GO:0050851)2.63048057
134response to type I interferon (GO:0034340)2.60216514
135negative regulation of erythrocyte differentiation (GO:0045647)2.59309288
136positive regulation of macrophage differentiation (GO:0045651)2.57184250
137germ cell migration (GO:0008354)2.56996189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.17584710
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.78436688
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.08581390
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.04404658
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.01350088
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.68005165
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.67200367
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65524677
9SCL_19346495_ChIP-Seq_HPC-7_Human3.58906508
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.45177290
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.34489098
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27530707
13IRF8_27001747_Chip-Seq_BMDM_Mouse3.19634092
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.16337438
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89698669
16VDR_21846776_ChIP-Seq_THP-1_Human2.80195078
17* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.60655623
18* SPI1_23547873_ChIP-Seq_NB4_Human2.57967080
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56359027
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55257979
21MYC_22102868_ChIP-Seq_BL_Human2.53899908
22MYB_26560356_Chip-Seq_TH2_Human2.39454658
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.37149137
24RUNX_20019798_ChIP-Seq_JUKART_Human2.36875069
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.34698824
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32874372
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.29452999
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.27400899
29VDR_24763502_ChIP-Seq_THP-1_Human2.27214831
30MAF_26560356_Chip-Seq_TH1_Human2.25761723
31BRD4_27068464_Chip-Seq_AML-cells_Mouse2.25438691
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22760610
33GATA1_22025678_ChIP-Seq_K562_Human2.21311810
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.20626782
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10114990
36MYB_26560356_Chip-Seq_TH1_Human2.07846094
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04637852
38SPI1_23127762_ChIP-Seq_K562_Human1.90914622
39TCF7_22412390_ChIP-Seq_EML_Mouse1.88884527
40UTX_26944678_Chip-Seq_JUKART_Human1.83000983
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79831162
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79187038
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77843576
44* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77330279
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75851557
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63964911
47PU_27001747_Chip-Seq_BMDM_Mouse1.63770314
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.61210460
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.60940322
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56701238
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51874844
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48256771
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46115660
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44237011
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43521383
56GATA3_27048872_Chip-Seq_THYMUS_Human1.42022732
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.40129375
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38964159
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34576843
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28792117
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28351064
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26998934
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23386832
64MAF_26560356_Chip-Seq_TH2_Human1.22184466
65GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22023916
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.21928316
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20851969
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19665041
69CIITA_25753668_ChIP-Seq_RAJI_Human1.18823634
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.17306038
71GATA3_26560356_Chip-Seq_TH2_Human1.15378965
72EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14037704
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13053087
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.12611165
75FOXP3_21729870_ChIP-Seq_TREG_Human1.11217033
76* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10962660
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09951715
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09482507
79KDM2B_26808549_Chip-Seq_DND41_Human1.05733920
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.03741942
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02515396
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02274047
83NCOR1_26117541_ChIP-Seq_K562_Human1.02265445
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00721704
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98474481
86GATA2_19941826_ChIP-Seq_K562_Human0.96677284
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96201277
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95759168
89ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94513407
90GATA1_19941826_ChIP-Seq_K562_Human0.93823636
91* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93796253
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93093750
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92078861
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92047800
95* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91484342
96VDR_24787735_ChIP-Seq_THP-1_Human0.90302319
97SMRT_27268052_Chip-Seq_Bcells_Human0.88886125
98VDR_23849224_ChIP-Seq_CD4+_Human0.88190168
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88070080
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85028157
101KDM2B_26808549_Chip-Seq_JURKAT_Human0.83450866
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83406873
103GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82054837
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81807053
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81140461
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81131844
107TFEB_21752829_ChIP-Seq_HELA_Human0.79859411
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78640130
109* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78377325
110* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77503072
111GATA3_26560356_Chip-Seq_TH1_Human0.76594429
112SPI1_20517297_ChIP-Seq_HL60_Human0.75915694
113E2F1_21310950_ChIP-Seq_MCF-7_Human0.74775298

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.27286511
2MP0005671_abnormal_response_to3.33509274
3MP0002396_abnormal_hematopoietic_system3.26221454
4* MP0003436_decreased_susceptibility_to2.99096084
5MP0009785_altered_susceptibility_to2.98325798
6* MP0001800_abnormal_humoral_immune2.96905486
7* MP0005000_abnormal_immune_tolerance2.83846530
8* MP0002452_abnormal_antigen_presenting2.77591124
9* MP0002419_abnormal_innate_immunity2.76529154
10MP0000685_abnormal_immune_system2.75063658
11MP0003303_peritoneal_inflammation2.73845387
12MP0001790_abnormal_immune_system2.67975688
13MP0005387_immune_system_phenotype2.67975688
14MP0002148_abnormal_hypersensitivity_rea2.67109205
15* MP0005025_abnormal_response_to2.62838199
16* MP0002723_abnormal_immune_serum2.58843091
17* MP0002420_abnormal_adaptive_immunity2.57935009
18* MP0001819_abnormal_immune_cell2.55426718
19* MP0005464_abnormal_platelet_physiology2.53869576
20* MP0002398_abnormal_bone_marrow2.37935357
21MP0004808_abnormal_hematopoietic_stem2.33947881
22MP0003300_gastrointestinal_ulcer2.27773877
23MP0005058_abnormal_lysosome_morphology2.19389442
24MP0003763_abnormal_thymus_physiology2.16277076
25MP0009278_abnormal_bone_marrow2.15558150
26* MP0000716_abnormal_immune_system2.11818432
27MP0006082_CNS_inflammation2.10872910
28MP0000689_abnormal_spleen_morphology2.06940829
29MP0003724_increased_susceptibility_to2.06560765
30MP0010155_abnormal_intestine_physiology1.99275106
31MP0005174_abnormal_tail_pigmentation1.96985351
32* MP0002722_abnormal_immune_system1.96043537
33MP0002405_respiratory_system_inflammati1.95590947
34MP0003183_abnormal_peptide_metabolism1.95096961
35MP0005397_hematopoietic_system_phenotyp1.93369510
36MP0001545_abnormal_hematopoietic_system1.93369510
37MP0002166_altered_tumor_susceptibility1.93035673
38MP0000465_gastrointestinal_hemorrhage1.92325767
39MP0005451_abnormal_body_composition1.92214448
40MP0001853_heart_inflammation1.87639195
41MP0009333_abnormal_splenocyte_physiolog1.86842399
42* MP0002429_abnormal_blood_cell1.84369387
43MP0005075_abnormal_melanosome_morpholog1.79661378
44* MP0001845_abnormal_inflammatory_respons1.74201489
45MP0003172_abnormal_lysosome_physiology1.72312222
46MP0002006_tumorigenesis1.69727803
47MP0008260_abnormal_autophagy1.68901093
48MP0003191_abnormal_cellular_cholesterol1.65451264
49* MP0000703_abnormal_thymus_morphology1.56061281
50MP0004947_skin_inflammation1.53078910
51* MP0001533_abnormal_skeleton_physiology1.52732416
52MP0004381_abnormal_hair_follicle1.45862852
53MP0000490_abnormal_crypts_of1.41623383
54MP0002132_abnormal_respiratory_system1.40236097
55MP0008469_abnormal_protein_level1.37808758
56MP0004510_myositis1.37734791
57MP0000858_altered_metastatic_potential1.36686334
58MP0002009_preneoplasia1.32536548
59MP0003866_abnormal_defecation1.31030735
60MP0001873_stomach_inflammation1.30207541
61MP0005310_abnormal_salivary_gland1.29510713
62MP0000343_altered_response_to1.28938724
63MP0004883_abnormal_blood_vessel1.28611833
64MP0000569_abnormal_digit_pigmentation1.20277213
65MP0008007_abnormal_cellular_replicative1.17739402
66MP0003448_altered_tumor_morphology1.12313294
67MP0003075_altered_response_to1.08921212
68MP0008057_abnormal_DNA_replication1.08509605
69MP0010307_abnormal_tumor_latency1.04521113
70MP0010352_gastrointestinal_tract_polyps1.04127173
71MP0010094_abnormal_chromosome_stability1.04075812
72MP0009764_decreased_sensitivity_to1.01187036
73MP0001851_eye_inflammation1.00790091
74MP0002933_joint_inflammation0.97632981
75MP0009840_abnormal_foam_cell0.96455572
76MP0002019_abnormal_tumor_incidence0.95968940
77MP0008004_abnormal_stomach_pH0.95651099
78MP0003656_abnormal_erythrocyte_physiolo0.94955131
79MP0003943_abnormal_hepatobiliary_system0.92509962
80* MP0009763_increased_sensitivity_to0.89417992
81MP0003828_pulmonary_edema0.88300822
82MP0000371_diluted_coat_color0.86565290
83MP0002877_abnormal_melanocyte_morpholog0.86376864
84MP0002998_abnormal_bone_remodeling0.85209592
85MP0002095_abnormal_skin_pigmentation0.84962780
86MP0005164_abnormal_response_to0.83745346
87MP0000015_abnormal_ear_pigmentation0.83692445
88MP0006054_spinal_hemorrhage0.81242423
89MP0002138_abnormal_hepatobiliary_system0.78434357
90MP0000604_amyloidosis0.77681622
91MP0003690_abnormal_glial_cell0.77223450
92MP0008058_abnormal_DNA_repair0.77129252
93MP0008873_increased_physiological_sensi0.74116731
94MP0004130_abnormal_muscle_cell0.72440950
95MP0001986_abnormal_taste_sensitivity0.71517629
96MP0000249_abnormal_blood_vessel0.70667817
97MP0003077_abnormal_cell_cycle0.70647290
98MP0005166_decreased_susceptibility_to0.70279685
99MP0003045_fibrosis0.68957482
100MP0003221_abnormal_cardiomyocyte_apopto0.65286735
101MP0001663_abnormal_digestive_system0.64891352
102MP0009765_abnormal_xenobiotic_induced0.64616101
103MP0005023_abnormal_wound_healing0.64579953
104MP0003111_abnormal_nucleus_morphology0.62947906
105MP0003795_abnormal_bone_structure0.62570364
106MP0003091_abnormal_cell_migration0.61260727
107MP0005076_abnormal_cell_differentiation0.59815668
108MP0009115_abnormal_fat_cell0.58215385
109MP0000313_abnormal_cell_death0.58211194
110MP0003566_abnormal_cell_adhesion0.57939426
111MP0000477_abnormal_intestine_morphology0.56983549
112MP0004147_increased_porphyrin_level0.56672419
113MP0002075_abnormal_coat/hair_pigmentati0.55887234
114* MP0005390_skeleton_phenotype0.55204225
115MP0002136_abnormal_kidney_physiology0.54660734
116MP0000598_abnormal_liver_morphology0.53889613
117MP0004484_altered_response_of0.52120827
118MP0000609_abnormal_liver_physiology0.50135337
119MP0002277_abnormal_respiratory_mucosa0.49824025
120MP0008874_decreased_physiological_sensi0.48369358
121MP0002332_abnormal_exercise_endurance0.45679674

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.30409502
2Recurrent bacterial skin infections (HP:0005406)4.87185891
3Prostate neoplasm (HP:0100787)4.62228484
4Eczematoid dermatitis (HP:0000976)4.53327766
5Agnosia (HP:0010524)4.10280471
6Vacuolated lymphocytes (HP:0001922)4.06492499
7Increased neuronal autofluorescent lipopigment (HP:0002074)4.06451522
8Myositis (HP:0100614)4.05837167
9Increased cerebral lipofuscin (HP:0011813)3.96862681
10Cellulitis (HP:0100658)3.89686097
11Recurrent viral infections (HP:0004429)3.83025006
12Elevated erythrocyte sedimentation rate (HP:0003565)3.76616502
13Agammaglobulinemia (HP:0004432)3.76120057
14Abnormality of the prostate (HP:0008775)3.75425702
15Recurrent fungal infections (HP:0002841)3.66544770
16Gastrointestinal stroma tumor (HP:0100723)3.56388782
17Gastrointestinal infarctions (HP:0005244)3.50945357
18Meningitis (HP:0001287)3.48653061
19Thrombocytosis (HP:0001894)3.45806585
20IgM deficiency (HP:0002850)3.32142701
21Recurrent gram-negative bacterial infections (HP:0005420)3.32018963
22Recurrent skin infections (HP:0001581)3.31428437
23Vasculitis (HP:0002633)3.25087880
24Chronic obstructive pulmonary disease (HP:0006510)3.19289211
25Obstructive lung disease (HP:0006536)3.19289211
26Cerebellar dysplasia (HP:0007033)3.19221609
27Mediastinal lymphadenopathy (HP:0100721)3.19212719
28Abnormal delayed hypersensitivity skin test (HP:0002963)3.13290543
29Prolonged bleeding time (HP:0003010)3.08387915
30Abnormality of macrophages (HP:0004311)3.08309078
31Orchitis (HP:0100796)3.06428090
32Panhypogammaglobulinemia (HP:0003139)3.02898234
33Inflammation of the large intestine (HP:0002037)2.97430674
34Optic neuritis (HP:0100653)2.94882055
35Retrobulbar optic neuritis (HP:0100654)2.94882055
36Autoimmune hemolytic anemia (HP:0001890)2.94584362
37Anterior segment dysgenesis (HP:0007700)2.93694338
38Chronic otitis media (HP:0000389)2.92798720
39Colitis (HP:0002583)2.91261231
40Axonal loss (HP:0003447)2.89093683
41Gastrointestinal inflammation (HP:0004386)2.88295767
42Hemoptysis (HP:0002105)2.87910182
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.87656602
44Spontaneous hematomas (HP:0007420)2.86343868
45Recurrent cutaneous fungal infections (HP:0011370)2.86130692
46Chronic mucocutaneous candidiasis (HP:0002728)2.86130692
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85225348
48Petechiae (HP:0000967)2.82757838
49Osteomyelitis (HP:0002754)2.79441578
50Amaurosis fugax (HP:0100576)2.78875622
51Epistaxis (HP:0000421)2.75387524
52Increased IgE level (HP:0003212)2.65651214
53Abnormality of T cells (HP:0002843)2.63933571
54Recurrent bronchitis (HP:0002837)2.62988310
55Lymphopenia (HP:0001888)2.62918346
56Abnormality of T cell physiology (HP:0011840)2.62900168
57Periodontitis (HP:0000704)2.61523003
58Autoimmune thrombocytopenia (HP:0001973)2.59377063
59Arterial thrombosis (HP:0004420)2.57766614
60Systemic lupus erythematosus (HP:0002725)2.55981922
61B lymphocytopenia (HP:0010976)2.55175757
62Abnormality of B cell number (HP:0010975)2.55175757
63Abnormality of cells of the lymphoid lineage (HP:0012140)2.54962310
64T lymphocytopenia (HP:0005403)2.54552526
65Thyroiditis (HP:0100646)2.54324042
66Abnormality of T cell number (HP:0011839)2.53207472
67Severe combined immunodeficiency (HP:0004430)2.51247937
68Gingival bleeding (HP:0000225)2.50811701
69Pulmonary embolism (HP:0002204)2.49260183
70Leukocytosis (HP:0001974)2.43927116
71Abnormality of eosinophils (HP:0001879)2.42345153
72Eosinophilia (HP:0001880)2.42145505
73Acute myeloid leukemia (HP:0004808)2.41962491
74Interstitial pulmonary disease (HP:0006530)2.40336096
75Pulmonary infiltrates (HP:0002113)2.36757145
76Viral hepatitis (HP:0006562)2.35353155
77Verrucae (HP:0200043)2.34358656
78Papilloma (HP:0012740)2.34358656
79Keratoconjunctivitis sicca (HP:0001097)2.33140288
80Impaired platelet aggregation (HP:0003540)2.32848035
81Abnormal platelet function (HP:0011869)2.32848035
82Hypoplasia of the thymus (HP:0000778)2.32079454
83Gingivitis (HP:0000230)2.31685699
84Stomatitis (HP:0010280)2.31429443
85Urticaria (HP:0001025)2.30299873
86Bundle branch block (HP:0011710)2.27798146
87Lymphoma (HP:0002665)2.26184065
88Encephalitis (HP:0002383)2.25663056
89Increased IgM level (HP:0003496)2.25630116
90Purpura (HP:0000979)2.25143765
91Gangrene (HP:0100758)2.24908156
92Granulocytopenia (HP:0001913)2.23412744
93IgG deficiency (HP:0004315)2.21373729
94Episodic fever (HP:0001954)2.21258091
95Chest pain (HP:0100749)2.21082315
96Anorexia (HP:0002039)2.19071963
97Pustule (HP:0200039)2.16438334
98Combined immunodeficiency (HP:0005387)2.16278510
99Spondylolisthesis (HP:0003302)2.14767789
100Abnormality of the fingertips (HP:0001211)2.14726812
101Dysostosis multiplex (HP:0000943)2.14703507
102Abnormality of the pleura (HP:0002103)2.14038140
103Aplasia/Hypoplasia of the thymus (HP:0010515)2.13889200
104Type II lissencephaly (HP:0007260)2.13724896
105Glomerulonephritis (HP:0000099)2.12977385
106Chronic diarrhea (HP:0002028)2.12180235
107Acute hepatic failure (HP:0006554)2.11831872
108Sepsis (HP:0100806)2.11294485
109Keratoconjunctivitis (HP:0001096)2.09250206
110Recurrent pneumonia (HP:0006532)2.05997158
111Nasal polyposis (HP:0100582)2.00868059
112Abnormality of liposaccharide metabolism (HP:0010968)2.00157649
113Abnormality of glycosphingolipid metabolism (HP:0004343)2.00157649
114Abnormality of glycolipid metabolism (HP:0010969)2.00157649
115Fatigue (HP:0012378)1.99738266
116Slow saccadic eye movements (HP:0000514)1.99587793
117Hypochromic anemia (HP:0001931)1.97418510
118Abnormal platelet volume (HP:0011876)1.97280215
119Emphysema (HP:0002097)1.96819447
120Acute lymphatic leukemia (HP:0006721)1.95993156
121Hematochezia (HP:0002573)1.95770710
122Hypochromic microcytic anemia (HP:0004840)1.95629190
123Recurrent lower respiratory tract infections (HP:0002783)1.95329827
124Skin rash (HP:0000988)1.94806056
125Vertigo (HP:0002321)1.94505053
126Increased mean platelet volume (HP:0011877)1.94470258
127Abnormality of the peritoneum (HP:0002585)1.93611787

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.96672184
2KIT3.95887170
3MAP3K143.29940175
4MAP3K103.26811564
5RIPK42.98649728
6FLT32.79539751
7IRAK42.64350348
8BLK2.62857752
9CSF1R2.60000735
10PRPF4B2.45276181
11TXK2.36530206
12TGFBR22.29840281
13BTK2.29138534
14TYK22.28189272
15TEC2.04788227
16TBK12.02612855
17CLK12.02165736
18MATK1.96534067
19ZAP701.83390827
20IKBKE1.82386666
21SYK1.81852003
22STK101.81236476
23JAK31.80197930
24ERN11.75173496
25EEF2K1.69898714
26IKBKB1.63072401
27MAP2K31.51592913
28IRAK31.50636196
29ITK1.47866150
30GRK61.46988560
31LCK1.44081441
32HCK1.39396559
33FES1.30540054
34LYN1.30430859
35FGR1.26898045
36JAK11.25814229
37RPS6KA41.24775910
38TAOK31.23102047
39IRAK11.18861116
40CSK1.18209529
41EPHB11.16768835
42MAP3K131.16604739
43PKN21.16020683
44PIM11.12850788
45MAP3K11.07680255
46CHUK1.07278468
47LRRK21.02075757
48KSR21.01253799
49CAMKK20.98035280
50STK40.95392953
51MAP3K110.91915998
52MAP3K30.91728206
53MAP3K20.89231329
54TRIB30.84344458
55NEK90.81910866
56MARK20.77388943
57IRAK20.76215892
58JAK20.76047934
59SIK20.75988817
60MAPK120.75590106
61NLK0.74912944
62PIK3CA0.72731946
63PIM20.72284696
64FGFR30.67312129
65TRPM70.66713270
66TAOK10.66279552
67BRD40.66135922
68MAPK40.66009898
69PAK40.65443824
70RAF10.65098688
71SGK20.64705646
72TGFBR10.64328059
73RPS6KA60.63792154
74SIK30.61544461
75SGK30.61255119
76PTK2B0.59270235
77PDPK10.58546171
78MAP3K50.58154556
79VRK10.57936218
80CDK120.56363798
81YES10.56284766
82WNK10.53862161
83RPS6KC10.52853977
84RPS6KL10.52853977
85RET0.52004296
86ADRBK20.51450339
87CDK40.51277968
88TESK20.50892839
89CDK60.49989890
90CAMK1D0.49511426
91TAOK20.49072174
92NEK20.48768419
93MAPKAPK20.48744117
94CDC70.48184662
95GRK70.47638536
96MAP3K120.46964821
97TNK20.46080731
98MAP2K60.45715813
99MAP3K80.42769246
100STK240.42540977
101PRKCQ0.41986956
102MARK30.41154260
103ATR0.41041768
104MAPK70.39325610
105PTK60.39093413
106HIPK20.38878065
107CAMKK10.38756993
108PDK10.38152948
109RPS6KB20.37015988
110CCNB10.36588740
111ABL10.35994975
112NME20.35561773
113KSR10.35506962
114MAPKAPK30.34782078
115MAP3K70.34432287
116FGFR40.32349758
117EPHA30.31499073
118PRKG20.30575350
119FYN0.30133521
120PRKCD0.29965182
121MAPK110.29453610
122STK110.29451000
123ALK0.29379986
124RPS6KA20.28831681
125RPS6KA50.28754551
126MAPK30.27801498
127IGF1R0.26392478
128BMPR20.25530340
129CAMK40.25431036
130MAP3K60.24352457
131EGFR0.23389031
132TTN0.23377672

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.13646908
2* B cell receptor signaling pathway_Homo sapiens_hsa046622.91320014
3Primary immunodeficiency_Homo sapiens_hsa053402.75255113
4* Osteoclast differentiation_Homo sapiens_hsa043802.62906198
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.34624297
6Staphylococcus aureus infection_Homo sapiens_hsa051502.22503872
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19215084
8Hematopoietic cell lineage_Homo sapiens_hsa046402.16736202
9* Measles_Homo sapiens_hsa051622.14172891
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.12257516
11* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10882668
12Antigen processing and presentation_Homo sapiens_hsa046122.00745575
13Legionellosis_Homo sapiens_hsa051341.99969254
14Other glycan degradation_Homo sapiens_hsa005111.90416329
15* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.87642366
16Pertussis_Homo sapiens_hsa051331.84315382
17* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79551270
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69115606
19DNA replication_Homo sapiens_hsa030301.66150158
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65838555
21Mismatch repair_Homo sapiens_hsa034301.63807001
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63676228
23Tuberculosis_Homo sapiens_hsa051521.62074750
24* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.61135288
25* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59242295
26Graft-versus-host disease_Homo sapiens_hsa053321.57900056
27* Toxoplasmosis_Homo sapiens_hsa051451.54883769
28Allograft rejection_Homo sapiens_hsa053301.54313629
29Herpes simplex infection_Homo sapiens_hsa051681.52240420
30* Influenza A_Homo sapiens_hsa051641.51587012
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.50201136
32* Acute myeloid leukemia_Homo sapiens_hsa052211.48516441
33* T cell receptor signaling pathway_Homo sapiens_hsa046601.46603071
34Asthma_Homo sapiens_hsa053101.42855564
35* Chemokine signaling pathway_Homo sapiens_hsa040621.40702222
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.40161263
37* Jak-STAT signaling pathway_Homo sapiens_hsa046301.36678522
38Malaria_Homo sapiens_hsa051441.35906427
39Shigellosis_Homo sapiens_hsa051311.33476639
40Lysosome_Homo sapiens_hsa041421.32936881
41* Hepatitis B_Homo sapiens_hsa051611.29765507
42* Platelet activation_Homo sapiens_hsa046111.26832476
43* TNF signaling pathway_Homo sapiens_hsa046681.25980861
44* Apoptosis_Homo sapiens_hsa042101.23520248
45* Leukocyte transendothelial migration_Homo sapiens_hsa046701.21797436
46Salmonella infection_Homo sapiens_hsa051321.20142692
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.19946485
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17245369
49Non-homologous end-joining_Homo sapiens_hsa034501.12758861
50* Chronic myeloid leukemia_Homo sapiens_hsa052201.09114084
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04245686
52Base excision repair_Homo sapiens_hsa034100.96084002
53* Pancreatic cancer_Homo sapiens_hsa052120.94682771
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93218732
55Rheumatoid arthritis_Homo sapiens_hsa053230.92536351
56Viral myocarditis_Homo sapiens_hsa054160.90827112
57* Viral carcinogenesis_Homo sapiens_hsa052030.87175670
58* Epstein-Barr virus infection_Homo sapiens_hsa051690.85956612
59Dorso-ventral axis formation_Homo sapiens_hsa043200.84925585
60* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82847122
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81911692
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80922131
63* Neurotrophin signaling pathway_Homo sapiens_hsa047220.78761368
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78719436
65Phagosome_Homo sapiens_hsa041450.78584374
66* Non-small cell lung cancer_Homo sapiens_hsa052230.78456816
67African trypanosomiasis_Homo sapiens_hsa051430.71616688
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70928026
69* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70906523
70* Hepatitis C_Homo sapiens_hsa051600.69431380
71* HTLV-I infection_Homo sapiens_hsa051660.68438704
72Homologous recombination_Homo sapiens_hsa034400.67665568
73* Renal cell carcinoma_Homo sapiens_hsa052110.67328642
74Ribosome_Homo sapiens_hsa030100.66982763
75Autoimmune thyroid disease_Homo sapiens_hsa053200.66604356
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66020072
77Systemic lupus erythematosus_Homo sapiens_hsa053220.65091120
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64553539
79* Small cell lung cancer_Homo sapiens_hsa052220.59136031
80Type I diabetes mellitus_Homo sapiens_hsa049400.58550836
81Fanconi anemia pathway_Homo sapiens_hsa034600.53997759
82* Phospholipase D signaling pathway_Homo sapiens_hsa040720.53342707
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52887924
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52723436
85* Prolactin signaling pathway_Homo sapiens_hsa049170.50728632
86* VEGF signaling pathway_Homo sapiens_hsa043700.49654936
87* mTOR signaling pathway_Homo sapiens_hsa041500.48680906
88GnRH signaling pathway_Homo sapiens_hsa049120.47988911
89* Colorectal cancer_Homo sapiens_hsa052100.46535996
90* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45758461
91Cell cycle_Homo sapiens_hsa041100.45250927
92* Choline metabolism in cancer_Homo sapiens_hsa052310.44651941
93p53 signaling pathway_Homo sapiens_hsa041150.43297201
94* Endometrial cancer_Homo sapiens_hsa052130.41495213
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.39850628
96* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39440064
97* HIF-1 signaling pathway_Homo sapiens_hsa040660.39428042
98Endocytosis_Homo sapiens_hsa041440.37618714
99Regulation of autophagy_Homo sapiens_hsa041400.37303430
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37294711
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37044926
102* Prostate cancer_Homo sapiens_hsa052150.36480662
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34885376
104* ErbB signaling pathway_Homo sapiens_hsa040120.34235798
105* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33141815
106* Sphingolipid signaling pathway_Homo sapiens_hsa040710.32875347
107* Glioma_Homo sapiens_hsa052140.32838209
108Spliceosome_Homo sapiens_hsa030400.32399457
109* Inositol phosphate metabolism_Homo sapiens_hsa005620.32275869
110Thyroid cancer_Homo sapiens_hsa052160.32039044
111Notch signaling pathway_Homo sapiens_hsa043300.31883615
112* Amoebiasis_Homo sapiens_hsa051460.31480077
113* Insulin resistance_Homo sapiens_hsa049310.31015925
114* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30492375
115N-Glycan biosynthesis_Homo sapiens_hsa005100.30039095
116* FoxO signaling pathway_Homo sapiens_hsa040680.29736002
117Long-term potentiation_Homo sapiens_hsa047200.29627429
118* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27935245
119Renin-angiotensin system_Homo sapiens_hsa046140.27756288
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.26666898
121MicroRNAs in cancer_Homo sapiens_hsa052060.25900700
122MAPK signaling pathway_Homo sapiens_hsa040100.25224542

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