PIK3IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)7.27625348
2negative regulation of cell killing (GO:0031342)7.27625348
3negative thymic T cell selection (GO:0045060)6.36024851
4tolerance induction (GO:0002507)6.00661529
5ribosomal small subunit assembly (GO:0000028)5.91909200
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.91449377
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.91449377
8negative regulation of erythrocyte differentiation (GO:0045647)5.41662184
9definitive hemopoiesis (GO:0060216)5.39349932
10positive T cell selection (GO:0043368)5.26011860
11positive thymic T cell selection (GO:0045059)5.20755760
12positive regulation of gamma-delta T cell activation (GO:0046645)5.12062525
13thymic T cell selection (GO:0045061)5.09327453
14T cell selection (GO:0045058)5.01880021
15regulation of B cell receptor signaling pathway (GO:0050855)5.01428775
16platelet dense granule organization (GO:0060155)4.88609897
17antigen processing and presentation via MHC class Ib (GO:0002475)4.81712418
18antigen processing and presentation of endogenous antigen (GO:0019883)4.77644868
19viral transcription (GO:0019083)4.69539091
20cellular response to interleukin-15 (GO:0071350)4.62738618
21leukocyte aggregation (GO:0070486)4.51388560
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.46385453
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44612243
24translational termination (GO:0006415)4.32485686
25blood vessel maturation (GO:0001955)4.25928811
26regulation of relaxation of muscle (GO:1901077)4.21177318
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.16725295
28regulation of gamma-delta T cell differentiation (GO:0045586)4.15978022
29lymphoid progenitor cell differentiation (GO:0002320)4.12963527
30megakaryocyte development (GO:0035855)4.09546273
31negative regulation of T cell mediated immunity (GO:0002710)4.08754407
32regulation of alpha-beta T cell proliferation (GO:0046640)4.06802661
33regulation of T cell tolerance induction (GO:0002664)4.06346585
34positive regulation of granulocyte differentiation (GO:0030854)3.80845563
35positive regulation of tolerance induction (GO:0002645)3.79250801
36translational elongation (GO:0006414)3.77797865
37mast cell activation involved in immune response (GO:0002279)3.77156159
38mast cell degranulation (GO:0043303)3.77156159
39mast cell activation (GO:0045576)3.71953832
40regulation of gamma-delta T cell activation (GO:0046643)3.71641690
41positive regulation of B cell differentiation (GO:0045579)3.70100999
42regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.69985537
43regulation of natural killer cell mediated immunity (GO:0002715)3.69985537
44regulation of tolerance induction (GO:0002643)3.69684904
45regulation of regulatory T cell differentiation (GO:0045589)3.69252839
46negative regulation of leukocyte mediated immunity (GO:0002704)3.69087131
47response to muramyl dipeptide (GO:0032495)3.68436043
48secretory granule organization (GO:0033363)3.66776561
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62881197
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62519685
51cotranslational protein targeting to membrane (GO:0006613)3.60488833
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.59278574
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59025589
54ribosomal small subunit biogenesis (GO:0042274)3.57981788
55protein targeting to ER (GO:0045047)3.56301023
56regulation of T cell mediated cytotoxicity (GO:0001914)3.55097692
57regulation of isotype switching to IgG isotypes (GO:0048302)3.50806991
58mucosal-associated lymphoid tissue development (GO:0048537)3.48385659
59Peyers patch development (GO:0048541)3.48385659
60regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.47270256
61establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46572111
62L-fucose metabolic process (GO:0042354)3.45377299
63L-fucose catabolic process (GO:0042355)3.45377299
64fucose catabolic process (GO:0019317)3.45377299
65protein localization to endoplasmic reticulum (GO:0070972)3.42365950
66mature B cell differentiation involved in immune response (GO:0002313)3.41863746
67negative regulation of innate immune response (GO:0045824)3.38291945
68viral life cycle (GO:0019058)3.33846242
69positive regulation of T cell mediated cytotoxicity (GO:0001916)3.31744808
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30337840
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.29973486
72detection of bacterium (GO:0016045)3.29827485
73alpha-beta T cell differentiation (GO:0046632)3.29246788
74cellular protein complex disassembly (GO:0043624)3.28441862
75detection of other organism (GO:0098543)3.27328834
76regulation of leukocyte mediated cytotoxicity (GO:0001910)3.24934899
77regulation of interleukin-2 biosynthetic process (GO:0045076)3.24869605
78cellular extravasation (GO:0045123)3.23397017
79positive regulation of T cell differentiation in thymus (GO:0033089)3.21693415
80T cell homeostasis (GO:0043029)3.18936607
81oxygen transport (GO:0015671)3.15424843
82angiogenesis involved in wound healing (GO:0060055)3.12147561
83lymph node development (GO:0048535)3.11771874
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.10554306
85positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09610652
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09290144
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.08337863
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07238834
89positive regulation of natural killer cell mediated immunity (GO:0002717)3.06261244
90positive regulation of interleukin-2 production (GO:0032743)3.04462044
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.03379313
92alpha-beta T cell activation (GO:0046631)3.02507235
93neutrophil activation involved in immune response (GO:0002283)3.01709587
94regulation of cell killing (GO:0031341)3.01265972
95modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00503489
96modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00503489
97positive regulation by organism of defense response of other organism involved in symbiotic interact3.00503489
98modulation by symbiont of host immune response (GO:0052553)3.00503489
99positive regulation by symbiont of host defense response (GO:0052509)3.00503489
100modulation by symbiont of host defense response (GO:0052031)3.00503489
101regulation of alpha-beta T cell activation (GO:0046634)3.00491210
102regulation of B cell differentiation (GO:0045577)2.99863822
103protein complex disassembly (GO:0043241)2.98173458
104response to interferon-beta (GO:0035456)2.97265481
105NIK/NF-kappaB signaling (GO:0038061)2.90807518
106regulation of cardiac muscle cell contraction (GO:0086004)2.89841801
107heparin metabolic process (GO:0030202)2.89558523
108heparin biosynthetic process (GO:0030210)2.89558523
109positive regulation of cell killing (GO:0031343)2.89516485
110T cell costimulation (GO:0031295)2.88016895
111DNA deamination (GO:0045006)2.86808146
112positive regulation of humoral immune response (GO:0002922)2.85931830
113neutrophil activation (GO:0042119)2.85306467
114lymphocyte homeostasis (GO:0002260)2.85016640
115lymphocyte costimulation (GO:0031294)2.83674973
116negative regulation of adaptive immune response (GO:0002820)2.82836302
117regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82640061
118positive regulation of alpha-beta T cell activation (GO:0046635)2.82367252
119negative regulation of interleukin-12 production (GO:0032695)2.82328499
120natural killer cell differentiation (GO:0001779)2.80953012
121phospholipid scrambling (GO:0017121)2.80759486
122CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.79602285
123T-helper cell differentiation (GO:0042093)2.79602285
124negative regulation of glycoprotein biosynthetic process (GO:0010561)2.77735059
125macromolecular complex disassembly (GO:0032984)2.75601973
126sodium ion export (GO:0071436)2.72894919
127L-serine transport (GO:0015825)2.71284072
128B cell receptor signaling pathway (GO:0050853)2.70855190
129interferon-gamma production (GO:0032609)2.70427169
130regulation of actin filament-based movement (GO:1903115)2.70399950
131embryonic hemopoiesis (GO:0035162)2.70297884
132mitochondrion degradation (GO:0000422)2.67113298
133positive regulation of respiratory burst (GO:0060267)2.66904573
134negative regulation of stress fiber assembly (GO:0051497)2.66675527
135response to interferon-alpha (GO:0035455)2.65991503
136fucosylation (GO:0036065)2.63143498
137activated T cell proliferation (GO:0050798)2.62553008
138serine transport (GO:0032329)2.62516270
139axonemal dynein complex assembly (GO:0070286)2.61734522
140response to interleukin-15 (GO:0070672)2.61464511
141peripheral nervous system neuron development (GO:0048935)2.60858854
142mature B cell differentiation (GO:0002335)2.59901832
143negative T cell selection (GO:0043383)2.59204837
144protein targeting to membrane (GO:0006612)2.58279287
145T cell receptor signaling pathway (GO:0050852)2.58125985
146positive regulation of natural killer cell differentiation (GO:0032825)2.57115020
147fusion of sperm to egg plasma membrane (GO:0007342)2.56145864
148antigen receptor-mediated signaling pathway (GO:0050851)2.53459089
149leukocyte homeostasis (GO:0001776)2.53352218
150regulation of T cell receptor signaling pathway (GO:0050856)2.51022963
151positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.50119974
152T cell differentiation (GO:0030217)2.48571849
153negative regulation of T cell apoptotic process (GO:0070233)2.48479286
154regulation of respiratory burst (GO:0060263)2.47035705
155maturation of SSU-rRNA (GO:0030490)2.46158170
156T cell migration (GO:0072678)2.45692878
157negative regulation of necroptotic process (GO:0060546)2.44333922
158acrosome reaction (GO:0007340)2.42159632
159response to type I interferon (GO:0034340)2.41355457
160cellular response to type I interferon (GO:0071357)2.38408102
161type I interferon signaling pathway (GO:0060337)2.38408102
162regulation of axon regeneration (GO:0048679)2.38394746
163regulation of neuron projection regeneration (GO:0070570)2.38394746
164regulation of natural killer cell differentiation (GO:0032823)2.38085047
165translational initiation (GO:0006413)2.37156323
166negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36158897
167regulation of granulocyte differentiation (GO:0030852)2.35448639
168negative regulation of T-helper cell differentiation (GO:0045623)2.34139461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.52511155
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.10147991
3RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.82244234
4LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.50339820
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43506225
6RUNX_20019798_ChIP-Seq_JUKART_Human3.30908409
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.28132632
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.00108350
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.66530651
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.64018835
11VDR_21846776_ChIP-Seq_THP-1_Human2.58820183
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.55998150
13EZH2_22144423_ChIP-Seq_EOC_Human2.37912895
14MYC_22102868_ChIP-Seq_BL_Human2.32647138
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.29314562
16* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.28470758
17* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.27939239
18* MYB_26560356_Chip-Seq_TH2_Human2.23670608
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20317718
20* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20054649
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13228845
22* MAF_26560356_Chip-Seq_TH1_Human2.11134533
23VDR_24763502_ChIP-Seq_THP-1_Human2.04111132
24* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.02008201
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00382574
26* TCF7_22412390_ChIP-Seq_EML_Mouse1.93872395
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93197301
28UTX_26944678_Chip-Seq_JUKART_Human1.92240115
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.88373306
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87076694
31* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83500267
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.82478204
33* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80268439
34SPI1_23127762_ChIP-Seq_K562_Human1.79035765
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.75860395
36* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73332341
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.64942299
38* MYB_26560356_Chip-Seq_TH1_Human1.61303074
39GATA1_22025678_ChIP-Seq_K562_Human1.60791725
40* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59234472
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56718955
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56532872
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52816012
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.51552629
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50303721
46SPI1_23547873_ChIP-Seq_NB4_Human1.47914778
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.47865261
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46851479
49MAF_26560356_Chip-Seq_TH2_Human1.45096317
50GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44349218
51KDM2B_26808549_Chip-Seq_DND41_Human1.43676728
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42761078
53VDR_24787735_ChIP-Seq_THP-1_Human1.34823226
54* GATA2_21666600_ChIP-Seq_HMVEC_Human1.34777121
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29765364
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.29505554
57CIITA_25753668_ChIP-Seq_RAJI_Human1.28959110
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27885033
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27166575
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26273791
61* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25710739
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25478560
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25317672
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23201498
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.22214402
66RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21690149
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19117167
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18611593
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18311188
70GATA1_19941826_ChIP-Seq_K562_Human1.17530411
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17190215
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14536099
73* PU_27001747_Chip-Seq_BMDM_Mouse1.10514975
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10127496
75ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08933606
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07731487
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06078568
78* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06053844
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05339835
80CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04589071
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04560843
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03825470
83DROSHA_22980978_ChIP-Seq_HELA_Human1.03551651
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03067288
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02494009
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02061655
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.01761359
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01316866
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01042460
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.00010091
91BCL6_27268052_Chip-Seq_Bcells_Human0.99259329
92GATA2_19941826_ChIP-Seq_K562_Human0.98808984
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98451659
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98224910
95* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97476543
96CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97335429
97* KDM2B_26808549_Chip-Seq_JURKAT_Human0.97249982
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.96994355
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.96961036
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96017089
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94547524
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94003243
103* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.92967534
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91781456
105BCOR_27268052_Chip-Seq_Bcells_Human0.91696465
106* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91129052
107LXR_22292898_ChIP-Seq_THP-1_Human0.90940519
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90260799
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.89481491
110CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88826153
111SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88221670
112RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87455045
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87115470
114* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83741448
115* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83468768
116IRF8_27001747_Chip-Seq_BMDM_Mouse0.83353033
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83060813
118GATA3_26560356_Chip-Seq_TH2_Human0.81601755
119GATA1_19941827_ChIP-Seq_MEL86_Mouse0.81534375
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81373608
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81054693
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80837646
123IGF1R_20145208_ChIP-Seq_DFB_Human0.80214492
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.79697244
125SMRT_27268052_Chip-Seq_Bcells_Human0.78008510
126RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76993146

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.05934627
2MP0003763_abnormal_thymus_physiology3.08486819
3MP0002396_abnormal_hematopoietic_system2.82893905
4MP0000685_abnormal_immune_system2.69024728
5MP0005671_abnormal_response_to2.48001384
6MP0001986_abnormal_taste_sensitivity2.45612323
7MP0005174_abnormal_tail_pigmentation2.31958047
8MP0005075_abnormal_melanosome_morpholog2.31064764
9MP0002166_altered_tumor_susceptibility2.25584450
10MP0004808_abnormal_hematopoietic_stem2.21657744
11MP0003303_peritoneal_inflammation2.17893725
12MP0000465_gastrointestinal_hemorrhage2.07202985
13MP0009379_abnormal_foot_pigmentation2.07010277
14MP0005410_abnormal_fertilization2.04722540
15MP0001835_abnormal_antigen_presentation2.01847726
16MP0001533_abnormal_skeleton_physiology1.97385201
17MP0008569_lethality_at_weaning1.92811869
18MP0003866_abnormal_defecation1.92757552
19MP0006082_CNS_inflammation1.92059393
20MP0000751_myopathy1.90280399
21MP0002398_abnormal_bone_marrow1.88801227
22MP0005464_abnormal_platelet_physiology1.87406559
23MP0001873_stomach_inflammation1.86976099
24MP0002095_abnormal_skin_pigmentation1.73052946
25MP0002420_abnormal_adaptive_immunity1.72892582
26MP0001819_abnormal_immune_cell1.66617030
27MP0001845_abnormal_inflammatory_respons1.65489162
28MP0001851_eye_inflammation1.64959733
29MP0004036_abnormal_muscle_relaxation1.64449312
30MP0003191_abnormal_cellular_cholesterol1.61692807
31MP0001800_abnormal_humoral_immune1.59969173
32MP0000703_abnormal_thymus_morphology1.59233034
33MP0001905_abnormal_dopamine_level1.58372066
34MP0009785_altered_susceptibility_to1.57884258
35MP0000716_abnormal_immune_system1.57478565
36MP0001545_abnormal_hematopoietic_system1.54644898
37MP0005397_hematopoietic_system_phenotyp1.54644898
38MP0005409_darkened_coat_color1.53381234
39MP0001853_heart_inflammation1.53378703
40MP0002723_abnormal_immune_serum1.52355094
41MP0000749_muscle_degeneration1.49693765
42MP0005310_abnormal_salivary_gland1.47712026
43MP0000372_irregular_coat_pigmentation1.47183129
44MP0003279_aneurysm1.44962930
45MP0004084_abnormal_cardiac_muscle1.43792639
46MP0005025_abnormal_response_to1.43501494
47MP0000689_abnormal_spleen_morphology1.43206275
48MP0002822_catalepsy1.43026463
49MP0002722_abnormal_immune_system1.41669647
50MP0002452_abnormal_antigen_presenting1.38582120
51MP0003828_pulmonary_edema1.38560415
52MP0001790_abnormal_immune_system1.37801016
53MP0005387_immune_system_phenotype1.37801016
54MP0001348_abnormal_lacrimal_gland1.36765159
55MP0002006_tumorigenesis1.35833074
56MP0008260_abnormal_autophagy1.34708196
57MP0002429_abnormal_blood_cell1.32531803
58MP0001968_abnormal_touch/_nociception1.32429953
59MP0002735_abnormal_chemical_nociception1.30299732
60MP0002138_abnormal_hepatobiliary_system1.28531495
61MP0009278_abnormal_bone_marrow1.28473646
62MP0004859_abnormal_synaptic_plasticity1.27681604
63MP0005000_abnormal_immune_tolerance1.27350430
64MP0004147_increased_porphyrin_level1.26121965
65MP0003300_gastrointestinal_ulcer1.25223244
66MP0002148_abnormal_hypersensitivity_rea1.24480075
67MP0002277_abnormal_respiratory_mucosa1.22752472
68MP0002998_abnormal_bone_remodeling1.22407216
69MP0008469_abnormal_protein_level1.20873899
70MP0002736_abnormal_nociception_after1.19461299
71MP0003172_abnormal_lysosome_physiology1.18705723
72MP0003646_muscle_fatigue1.18179095
73MP0000920_abnormal_myelination1.17729192
74MP0000747_muscle_weakness1.16901824
75MP0000015_abnormal_ear_pigmentation1.12415941
76MP0001188_hyperpigmentation1.10250279
77MP0002272_abnormal_nervous_system1.10178461
78MP0002009_preneoplasia1.10034475
79MP0004510_myositis1.08907112
80MP0009764_decreased_sensitivity_to1.07999159
81MP0003724_increased_susceptibility_to1.07606559
82MP0009840_abnormal_foam_cell1.07018241
83MP0002933_joint_inflammation1.06567198
84MP0004883_abnormal_blood_vessel1.05264247
85MP0000858_altered_metastatic_potential1.04709740
86MP0001502_abnormal_circadian_rhythm1.03044892
87MP0010155_abnormal_intestine_physiology1.01751534
88MP0002419_abnormal_innate_immunity1.00250037
89MP0000604_amyloidosis0.99769207
90MP0008961_abnormal_basal_metabolism0.95197427
91MP0002638_abnormal_pupillary_reflex0.94503404
92MP0004130_abnormal_muscle_cell0.93358315
93MP0001970_abnormal_pain_threshold0.92115384
94MP0002106_abnormal_muscle_physiology0.91217992
95MP0005423_abnormal_somatic_nervous0.90204743
96MP0009333_abnormal_splenocyte_physiolog0.89796493
97MP0004215_abnormal_myocardial_fiber0.89705673
98MP0003690_abnormal_glial_cell0.88557109
99MP0003635_abnormal_synaptic_transmissio0.88003572
100MP0004145_abnormal_muscle_electrophysio0.87380034
101MP0000681_abnormal_thyroid_gland0.87213564
102MP0005451_abnormal_body_composition0.86998079
103MP0002733_abnormal_thermal_nociception0.86770591
104MP0008874_decreased_physiological_sensi0.86306965
105MP0001270_distended_abdomen0.84799081
106MP0001663_abnormal_digestive_system0.84607751
107MP0009745_abnormal_behavioral_response0.84255715
108MP0002254_reproductive_system_inflammat0.82961775
109MP0002837_dystrophic_cardiac_calcinosis0.81570177
110MP0008995_early_reproductive_senescence0.81431881
111MP0005390_skeleton_phenotype0.79918574
112MP0004381_abnormal_hair_follicle0.77871990
113MP0000249_abnormal_blood_vessel0.77524652
114MP0002405_respiratory_system_inflammati0.77025927
115MP0004270_analgesia0.76090001
116MP0004885_abnormal_endolymph0.75885623
117MP0003045_fibrosis0.75438649
118MP0003698_abnormal_male_reproductive0.75412436
119MP0003329_amyloid_beta_deposits0.75256169
120MP0009763_increased_sensitivity_to0.75247954
121MP0003183_abnormal_peptide_metabolism0.73638481
122MP0005164_abnormal_response_to0.73598134
123MP0002089_abnormal_postnatal_growth/wei0.73041320
124MP0003633_abnormal_nervous_system0.72828121
125MP0006054_spinal_hemorrhage0.72530714
126MP0004858_abnormal_nervous_system0.72529517
127MP0003448_altered_tumor_morphology0.71303349
128MP0004947_skin_inflammation0.70330173
129MP0002067_abnormal_sensory_capabilities0.68899347
130MP0004484_altered_response_of0.68415163
131MP0005166_decreased_susceptibility_to0.67966267
132MP0008004_abnormal_stomach_pH0.66922898
133MP0002132_abnormal_respiratory_system0.65764471
134MP0001501_abnormal_sleep_pattern0.64489317
135MP0005058_abnormal_lysosome_morphology0.64455018
136MP0005369_muscle_phenotype0.64283746
137MP0000490_abnormal_crypts_of0.63536316
138MP0003795_abnormal_bone_structure0.62602839
139MP0003075_altered_response_to0.60521947
140MP0002019_abnormal_tumor_incidence0.59208301
141MP0003656_abnormal_erythrocyte_physiolo0.57815383
142MP0009115_abnormal_fat_cell0.57683224
143MP0003091_abnormal_cell_migration0.57279259
144MP0001765_abnormal_ion_homeostasis0.56751477
145MP0009765_abnormal_xenobiotic_induced0.56721237
146MP0002693_abnormal_pancreas_physiology0.54367249
147MP0005535_abnormal_body_temperature0.52220369
148MP0002136_abnormal_kidney_physiology0.51818440

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.14287290
2Stomatitis (HP:0010280)5.44251168
3Chronic otitis media (HP:0000389)4.88909968
4Pustule (HP:0200039)4.58432416
5Nasal polyposis (HP:0100582)4.48510923
6Abnormality of the nasal mucosa (HP:0000433)4.38200657
7Recurrent bacterial skin infections (HP:0005406)4.29854922
8Hypothermia (HP:0002045)4.13786186
9Recurrent fungal infections (HP:0002841)4.13315581
10Recurrent abscess formation (HP:0002722)4.12414648
11Thrombocytosis (HP:0001894)4.05090230
12Severe combined immunodeficiency (HP:0004430)4.03858281
13Elevated erythrocyte sedimentation rate (HP:0003565)3.89921360
14Orchitis (HP:0100796)3.78828298
15Retrobulbar optic neuritis (HP:0100654)3.72501561
16Optic neuritis (HP:0100653)3.72501561
17Recurrent bronchitis (HP:0002837)3.72444017
18Gastrointestinal infarctions (HP:0005244)3.65002508
19Mediastinal lymphadenopathy (HP:0100721)3.56709172
20Abnormality of macrophages (HP:0004311)3.53514150
21Abnormality of cells of the erythroid lineage (HP:0012130)3.51923597
22Abnormal number of erythroid precursors (HP:0012131)3.45247849
23Dynein arm defect of respiratory motile cilia (HP:0012255)3.42950946
24Absent/shortened dynein arms (HP:0200106)3.42950946
25Chronic sinusitis (HP:0011109)3.38616153
26Papilledema (HP:0001085)3.37856726
27Vasculitis (HP:0002633)3.35390042
28Panhypogammaglobulinemia (HP:0003139)3.32853709
29Nonprogressive disorder (HP:0003680)3.29303540
30Chronic mucocutaneous candidiasis (HP:0002728)3.28248215
31Recurrent cutaneous fungal infections (HP:0011370)3.28248215
32Peripheral hypomyelination (HP:0007182)3.26239099
33Leukocytosis (HP:0001974)3.26200555
34Aplastic anemia (HP:0001915)3.24583578
35Abnormality of eosinophils (HP:0001879)3.21339093
36Encephalitis (HP:0002383)3.19224636
37Recurrent skin infections (HP:0001581)3.17567686
38IgM deficiency (HP:0002850)3.16301899
39Granulocytopenia (HP:0001913)3.14486251
40Pulmonary infiltrates (HP:0002113)3.10541599
41Combined immunodeficiency (HP:0005387)3.09390487
42Autoimmune hemolytic anemia (HP:0001890)3.07655686
43Abnormality of T cell physiology (HP:0011840)3.06020980
44Stomach cancer (HP:0012126)3.02983787
45Prolonged bleeding time (HP:0003010)2.99707020
46Obstructive lung disease (HP:0006536)2.97131441
47Chronic obstructive pulmonary disease (HP:0006510)2.97131441
48Eosinophilia (HP:0001880)2.96812223
49Papilloma (HP:0012740)2.95032395
50Verrucae (HP:0200043)2.95032395
51Increased IgM level (HP:0003496)2.91829895
52Bronchitis (HP:0012387)2.86870855
53Recurrent gram-negative bacterial infections (HP:0005420)2.85993870
54Abnormality of cells of the lymphoid lineage (HP:0012140)2.82856550
55Abnormal respiratory motile cilium morphology (HP:0005938)2.81363323
56Abnormal respiratory epithelium morphology (HP:0012253)2.81363323
57Exercise-induced myalgia (HP:0003738)2.77546410
58Colitis (HP:0002583)2.77160289
59Type 2 muscle fiber atrophy (HP:0003554)2.74199317
60Petechiae (HP:0000967)2.73287853
61Keratoconjunctivitis sicca (HP:0001097)2.69745554
62Hemoptysis (HP:0002105)2.62951936
63Keratoconjunctivitis (HP:0001096)2.62298845
64Hypoproteinemia (HP:0003075)2.57255356
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55661314
66Chronic diarrhea (HP:0002028)2.54999923
67Myositis (HP:0100614)2.54071972
68T lymphocytopenia (HP:0005403)2.52259854
69Muscle fiber atrophy (HP:0100295)2.48746399
70Abnormal respiratory motile cilium physiology (HP:0012261)2.48552880
71Slow saccadic eye movements (HP:0000514)2.44477888
72Bronchiectasis (HP:0002110)2.44052566
73Gingivitis (HP:0000230)2.43802277
74Hematochezia (HP:0002573)2.41646711
75Pulmonary embolism (HP:0002204)2.41613475
76Joint swelling (HP:0001386)2.35919053
77Agammaglobulinemia (HP:0004432)2.35186831
78Abnormal ciliary motility (HP:0012262)2.32774751
79Weak cry (HP:0001612)2.31883379
80Basal cell carcinoma (HP:0002671)2.30881212
81Urticaria (HP:0001025)2.29727730
82Recurrent viral infections (HP:0004429)2.26948508
83Hypochromic anemia (HP:0001931)2.26572433
84Gingival bleeding (HP:0000225)2.23374955
85Abnormality of T cell number (HP:0011839)2.19600822
86Easy fatigability (HP:0003388)2.18061579
87Retinal dysplasia (HP:0007973)2.16751265
88Abnormality of B cell number (HP:0010975)2.16295082
89B lymphocytopenia (HP:0010976)2.16295082
90Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14834993
91Abnormal protein N-linked glycosylation (HP:0012347)2.14834993
92Abnormal protein glycosylation (HP:0012346)2.14834993
93Abnormal glycosylation (HP:0012345)2.14834993
94Abnormality of T cells (HP:0002843)2.14342561
95Asplenia (HP:0001746)2.11119870
96Rhinitis (HP:0012384)2.10996108
97Anorexia (HP:0002039)2.09605130
98Myotonia (HP:0002486)2.09057546
99Type I transferrin isoform profile (HP:0003642)2.08155304
100Visual hallucinations (HP:0002367)2.07962733
101Acute lymphatic leukemia (HP:0006721)2.07125053
102Loss of speech (HP:0002371)2.06907818
103Episodic fever (HP:0001954)2.06577679
104Abnormality of the fingertips (HP:0001211)2.06012726
105Autoimmune thrombocytopenia (HP:0001973)2.05459848
106Distal arthrogryposis (HP:0005684)2.05083816
107Hypoplasia of the thymus (HP:0000778)2.04622768
108Inflammation of the large intestine (HP:0002037)2.03576416
109Gastrointestinal stroma tumor (HP:0100723)2.03310652
110Sepsis (HP:0100806)2.03159528
111Arterial thrombosis (HP:0004420)2.01764874
112Abnormal delayed hypersensitivity skin test (HP:0002963)2.00920580
113Microcytic anemia (HP:0001935)2.00131712
114Gastrointestinal inflammation (HP:0004386)1.99654320
115Spinal canal stenosis (HP:0003416)1.97560756
116Reticulocytopenia (HP:0001896)1.96482454
117Alveolar cell carcinoma (HP:0006519)1.96285677
118Abnormality of the pleura (HP:0002103)1.96253701
119Broad metatarsal (HP:0001783)1.94631998
120Restrictive lung disease (HP:0002091)1.94459264
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93671152
122Severe visual impairment (HP:0001141)1.91999819
123Obstructive sleep apnea (HP:0002870)1.91599867
124Gangrene (HP:0100758)1.91353700
125Progressive inability to walk (HP:0002505)1.90907738
126Premature loss of primary teeth (HP:0006323)1.90584943
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.89787888
128Broad face (HP:0000283)1.89637862
129Epistaxis (HP:0000421)1.88908834
130Cellulitis (HP:0100658)1.88850156
131Progressive neurologic deterioration (HP:0002344)1.88785536
132IgG deficiency (HP:0004315)1.88742953
133Thyroiditis (HP:0100646)1.88642111
134Fatigue (HP:0012378)1.87964784
135Neoplasm of the tracheobronchial system (HP:0100552)1.86307305
136Seborrheic dermatitis (HP:0001051)1.85274327
137Increased IgE level (HP:0003212)1.84679930
138Gonadotropin excess (HP:0000837)1.84270637
139Osteomyelitis (HP:0002754)1.82373605
140Abnormal platelet function (HP:0011869)1.81761046
141Impaired platelet aggregation (HP:0003540)1.81761046
142Pallor (HP:0000980)1.81624570
143Abnormality of the prostate (HP:0008775)1.81520693
144Purpura (HP:0000979)1.80810575
145Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80771284
146Lymphoma (HP:0002665)1.80046338
147Type II lissencephaly (HP:0007260)1.79978732
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.79894325
149Infertility (HP:0000789)1.76151393
150Abnormality of the neuromuscular junction (HP:0003398)1.75429149
151Fatigable weakness (HP:0003473)1.75429149
152Meningitis (HP:0001287)1.74604844
153Spontaneous hematomas (HP:0007420)1.74484878
154Lymphopenia (HP:0001888)1.73320533
155Hepatocellular necrosis (HP:0001404)1.72147376
156Muscle hypertrophy of the lower extremities (HP:0008968)1.69512099
157Asymmetric septal hypertrophy (HP:0001670)1.69041219
158Recurrent sinusitis (HP:0011108)1.69013878
159Calf muscle hypertrophy (HP:0008981)1.68228506
160Spondylolisthesis (HP:0003302)1.67023199
161Interstitial pulmonary disease (HP:0006530)1.66310912
162Hypergammaglobulinemia (HP:0010702)1.66169602
163Chest pain (HP:0100749)1.65560548
164Hyperacusis (HP:0010780)1.63348859
165Poikiloderma (HP:0001029)1.61893755
166Mitral regurgitation (HP:0001653)1.60918943
167Erythema (HP:0010783)1.60029395
168Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59456093

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.75635035
2EEF2K3.69134595
3TNIK3.66280634
4MAP4K13.21378301
5TAOK32.80896905
6PRPF4B2.78284039
7KIT2.64018028
8MAPKAPK52.51864705
9RIPK42.44701651
10FLT32.28642596
11TEC2.25220898
12BTK2.23012916
13CDK192.14878496
14LMTK22.03497948
15NLK2.02193374
16TXK1.99057643
17CSK1.91504605
18SIK31.89721635
19MAP3K121.88584284
20MAP3K141.87999096
21PASK1.82570184
22CAMKK11.72799912
23BLK1.72684766
24MAPKAPK31.60838309
25ZAP701.60697147
26PHKG21.56377999
27PHKG11.56377999
28ERN11.54444408
29MATK1.54362206
30SYK1.49969116
31MYLK1.44500558
32LRRK21.42711413
33SIK21.40006199
34MAP3K101.39884878
35ITK1.39341070
36RPS6KB21.38702131
37TGFBR21.38673200
38JAK31.38200795
39CSF1R1.37400939
40FES1.36848024
41MAP2K31.34314801
42NME21.33710874
43TIE11.32275803
44IKBKE1.29983951
45TGFBR11.28676898
46TESK21.26898119
47MARK31.24361385
48TRPM71.22466818
49GRK61.19441886
50DYRK31.18465277
51CAMK11.15941846
52LCK1.07625387
53MAP3K31.07557025
54STK161.06210244
55EPHB11.05493011
56MAP3K130.99187700
57HCK0.97315873
58PINK10.96695901
59HIPK20.95681102
60MAP2K20.94878542
61CAMKK20.93685983
62MAPK120.91636503
63PDK30.91209097
64PDK40.91209097
65PRKD20.91189479
66SIK10.90380494
67TTN0.89814658
68MAP3K110.88575148
69EPHA30.88348555
70MAP3K70.84992516
71TBK10.84296928
72PKN20.83177424
73PIM20.81532572
74MARK20.80988289
75PDK10.79847326
76TRIB30.78353135
77MAPK40.75259897
78TNK20.75092511
79RIPK10.74966746
80ADRBK20.74814797
81TYK20.72785242
82PRKCH0.71962713
83DYRK1B0.71322241
84CSNK1G30.70950486
85RET0.70550959
86CDK120.67098205
87MAP2K60.67005641
88FGFR30.66630832
89FGFR40.62980692
90TAOK10.62894699
91ILK0.61867998
92TYRO30.60929811
93FGR0.60695903
94NTRK20.60676112
95IRAK10.60485621
96CDC42BPA0.59679499
97SGK20.56612342
98NEK60.56581672
99STK380.56494886
100FYN0.56282872
101MAP3K10.56189565
102LYN0.55336761
103MAPK130.54699886
104RAF10.54305250
105NTRK10.54163346
106MAPK110.53721389
107CDK40.52818931
108SGK30.51046995
109CSNK1G10.49403014
110CHUK0.49165160
111GRK70.48734987
112BMPR20.48377495
113IRAK40.47865771
114CAMK40.47046039
115RPS6KA60.45768548
116IRAK20.45717816
117PDGFRB0.45085295
118CSNK1G20.42532290
119PTK60.42013032
120PRKG20.41749644
121PTK2B0.41069920
122SGK4940.40292506
123SGK2230.40292506
124IKBKB0.39891327
125PIK3CG0.39573491
126STK390.38291993
127PRKD10.38147249
128BRD40.38098696
129BCKDK0.38025853
130PDPK10.37326107
131MELK0.37210527
132ADRBK10.36935720
133MAPK70.36151237
134JAK10.36061195
135YES10.35718953
136UHMK10.34397707
137RPS6KL10.33073093
138RPS6KC10.33073093
139PIM10.32614368
140GRK50.32501854
141STK100.31818761
142PRKCQ0.30945520
143RPS6KA50.30542820
144CLK10.30487334
145MAPK150.29505055
146MAPK30.28628573
147ROCK20.28227901
148JAK20.27738260

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.41079288
2Ribosome_Homo sapiens_hsa030103.18682882
3Graft-versus-host disease_Homo sapiens_hsa053322.51345896
4Allograft rejection_Homo sapiens_hsa053302.50440680
5Autoimmune thyroid disease_Homo sapiens_hsa053202.44674246
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.36682265
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06398973
8B cell receptor signaling pathway_Homo sapiens_hsa046622.05410760
9Type I diabetes mellitus_Homo sapiens_hsa049401.79779679
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66757161
11T cell receptor signaling pathway_Homo sapiens_hsa046601.64937475
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61750487
13Staphylococcus aureus infection_Homo sapiens_hsa051501.61562354
14Platelet activation_Homo sapiens_hsa046111.58993235
15Hematopoietic cell lineage_Homo sapiens_hsa046401.49638669
16Viral myocarditis_Homo sapiens_hsa054161.45640345
17TNF signaling pathway_Homo sapiens_hsa046681.44203266
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43736442
19Acute myeloid leukemia_Homo sapiens_hsa052211.41737278
20Tuberculosis_Homo sapiens_hsa051521.34246328
21Malaria_Homo sapiens_hsa051441.27187243
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24879615
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24517872
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22308576
25Olfactory transduction_Homo sapiens_hsa047401.21223221
26Measles_Homo sapiens_hsa051621.19255109
27Circadian entrainment_Homo sapiens_hsa047131.18218205
28Calcium signaling pathway_Homo sapiens_hsa040201.16492903
29Influenza A_Homo sapiens_hsa051641.15576773
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.12279433
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12053999
32Osteoclast differentiation_Homo sapiens_hsa043801.09469300
33N-Glycan biosynthesis_Homo sapiens_hsa005101.09291610
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09192203
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08628897
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.07825781
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07487096
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05929890
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05504053
40Salivary secretion_Homo sapiens_hsa049701.05437441
41Asthma_Homo sapiens_hsa053101.04978967
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04655231
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02419382
44Gastric acid secretion_Homo sapiens_hsa049710.99413826
45Hepatitis C_Homo sapiens_hsa051600.98513614
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96636792
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.96567563
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.95351717
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94201212
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.92644369
51Non-homologous end-joining_Homo sapiens_hsa034500.92447451
52Thyroid cancer_Homo sapiens_hsa052160.92254176
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91989870
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91778440
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.90970772
56FoxO signaling pathway_Homo sapiens_hsa040680.90940720
57Apoptosis_Homo sapiens_hsa042100.89416753
58Other glycan degradation_Homo sapiens_hsa005110.89142616
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88917885
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88578267
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88303006
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88290455
63Pancreatic cancer_Homo sapiens_hsa052120.87598019
64Cardiac muscle contraction_Homo sapiens_hsa042600.86358831
65Choline metabolism in cancer_Homo sapiens_hsa052310.85154310
66Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84798437
67Leishmaniasis_Homo sapiens_hsa051400.83412364
68Shigellosis_Homo sapiens_hsa051310.83124450
69Glutamatergic synapse_Homo sapiens_hsa047240.82779842
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82668233
71Renal cell carcinoma_Homo sapiens_hsa052110.81482694
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80246098
73Endometrial cancer_Homo sapiens_hsa052130.79841394
74Morphine addiction_Homo sapiens_hsa050320.79755251
75Legionellosis_Homo sapiens_hsa051340.79587323
76Cholinergic synapse_Homo sapiens_hsa047250.79552978
77Toxoplasmosis_Homo sapiens_hsa051450.78886421
78Renin secretion_Homo sapiens_hsa049240.78146151
79Pertussis_Homo sapiens_hsa051330.77989647
80Regulation of autophagy_Homo sapiens_hsa041400.77861126
81Rheumatoid arthritis_Homo sapiens_hsa053230.77268138
82cAMP signaling pathway_Homo sapiens_hsa040240.76277379
83HTLV-I infection_Homo sapiens_hsa051660.75331664
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74989740
85Taste transduction_Homo sapiens_hsa047420.74463794
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.74263043
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.74004671
88Antigen processing and presentation_Homo sapiens_hsa046120.73902894
89Oxytocin signaling pathway_Homo sapiens_hsa049210.73554494
90Insulin secretion_Homo sapiens_hsa049110.71918508
91Prolactin signaling pathway_Homo sapiens_hsa049170.71644924
92Epstein-Barr virus infection_Homo sapiens_hsa051690.71603701
93Non-small cell lung cancer_Homo sapiens_hsa052230.71437310
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71030860
95Long-term potentiation_Homo sapiens_hsa047200.70248906
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69656725
97Chronic myeloid leukemia_Homo sapiens_hsa052200.69280518
98VEGF signaling pathway_Homo sapiens_hsa043700.68934099
99Cocaine addiction_Homo sapiens_hsa050300.68701412
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.68233250
101mTOR signaling pathway_Homo sapiens_hsa041500.67923068
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66217972
103African trypanosomiasis_Homo sapiens_hsa051430.65903351
104Viral carcinogenesis_Homo sapiens_hsa052030.65792847
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65520994
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.65194477
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63650528
108Dilated cardiomyopathy_Homo sapiens_hsa054140.62995319
109Herpes simplex infection_Homo sapiens_hsa051680.62032317
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.61178417
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.60708298
112Amphetamine addiction_Homo sapiens_hsa050310.58996237
113Dorso-ventral axis formation_Homo sapiens_hsa043200.58976063
114Insulin resistance_Homo sapiens_hsa049310.58931682
115Salmonella infection_Homo sapiens_hsa051320.58159964
116Inositol phosphate metabolism_Homo sapiens_hsa005620.57771485
117Protein export_Homo sapiens_hsa030600.57374110
118Serotonergic synapse_Homo sapiens_hsa047260.57123784
119GnRH signaling pathway_Homo sapiens_hsa049120.56734749
120Colorectal cancer_Homo sapiens_hsa052100.56441259
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55274246
122Chemokine signaling pathway_Homo sapiens_hsa040620.54910171
123Notch signaling pathway_Homo sapiens_hsa043300.54722187
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54433894
125Ras signaling pathway_Homo sapiens_hsa040140.54303875
126Pancreatic secretion_Homo sapiens_hsa049720.52691401
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52058857
128Dopaminergic synapse_Homo sapiens_hsa047280.51856072
129Purine metabolism_Homo sapiens_hsa002300.50844374
130Hepatitis B_Homo sapiens_hsa051610.50456923
131Endocytosis_Homo sapiens_hsa041440.49531390
132Phagosome_Homo sapiens_hsa041450.49442925
133Circadian rhythm_Homo sapiens_hsa047100.49356740
134ErbB signaling pathway_Homo sapiens_hsa040120.49267972
135Fatty acid elongation_Homo sapiens_hsa000620.48744384
136MAPK signaling pathway_Homo sapiens_hsa040100.47562043
137Prostate cancer_Homo sapiens_hsa052150.45569350
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.44001505
139Lysosome_Homo sapiens_hsa041420.39500352
140Type II diabetes mellitus_Homo sapiens_hsa049300.39055417
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37710694
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37243494
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33618174
144Rap1 signaling pathway_Homo sapiens_hsa040150.32246169

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