PIK3R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69086381
2L-amino acid import (GO:0043092)3.44876577
3positive regulation of fibroblast migration (GO:0010763)3.41944882
4negative regulation of erythrocyte differentiation (GO:0045647)3.21737475
5membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20227381
6synaptic vesicle docking involved in exocytosis (GO:0016081)3.10015392
7regulation of synaptic vesicle exocytosis (GO:2000300)2.94447258
8* growth hormone receptor signaling pathway (GO:0060396)2.88744647
9cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87646768
10sodium ion export (GO:0071436)2.87286773
11cellular potassium ion homeostasis (GO:0030007)2.87079729
12negative thymic T cell selection (GO:0045060)2.83032251
13regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82216183
14negative T cell selection (GO:0043383)2.81867781
15cell migration involved in heart development (GO:0060973)2.67497554
16amino acid import (GO:0043090)2.67328589
17cerebellar Purkinje cell differentiation (GO:0021702)2.67295997
18positive regulation of Rap GTPase activity (GO:0032854)2.67028103
19regulation of synaptic vesicle transport (GO:1902803)2.65387344
20nucleobase catabolic process (GO:0046113)2.64154390
21positive T cell selection (GO:0043368)2.63645023
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.62383338
23cellular response to epinephrine stimulus (GO:0071872)2.59999454
24regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.58577377
25synaptic vesicle exocytosis (GO:0016079)2.57910810
26positive regulation of fatty acid beta-oxidation (GO:0032000)2.51328791
27nerve growth factor signaling pathway (GO:0038180)2.50590988
28cardiac ventricle formation (GO:0003211)2.50590930
29regulation of Rap GTPase activity (GO:0032317)2.48610857
30activated T cell proliferation (GO:0050798)2.47931938
31cerebellar granule cell differentiation (GO:0021707)2.45372018
32cellular response to ethanol (GO:0071361)2.43582827
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.42058371
34* cellular response to growth hormone stimulus (GO:0071378)2.41321669
35interkinetic nuclear migration (GO:0022027)2.40808382
36regulation of sequestering of triglyceride (GO:0010889)2.40621076
37response to muramyl dipeptide (GO:0032495)2.40489267
38positive thymic T cell selection (GO:0045059)2.40488723
39regulation of B cell receptor signaling pathway (GO:0050855)2.39689549
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39208982
41potassium ion import (GO:0010107)2.38928942
42positive regulation of extracellular matrix organization (GO:1903055)2.38502647
43alpha-linolenic acid metabolic process (GO:0036109)2.38059537
44positive regulation of histone deacetylation (GO:0031065)2.33436526
45cardiac chamber formation (GO:0003207)2.32032755
46thymic T cell selection (GO:0045061)2.29902948
47pyrimidine nucleobase catabolic process (GO:0006208)2.29726649
48T cell selection (GO:0045058)2.29628681
49ionotropic glutamate receptor signaling pathway (GO:0035235)2.28643124
50cell communication by electrical coupling (GO:0010644)2.27586854
51positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27520622
52regulation of voltage-gated calcium channel activity (GO:1901385)2.27454011
53establishment of protein localization to Golgi (GO:0072600)2.23810719
54positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.22632338
55fatty acid transmembrane transport (GO:1902001)2.22210164
56positive regulation of fatty acid oxidation (GO:0046321)2.21609070
57sleep (GO:0030431)2.21327482
58regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.21298810
59cytoplasmic mRNA processing body assembly (GO:0033962)2.21176673
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.19919679
61synaptic vesicle maturation (GO:0016188)2.18951461
62positive regulation of glycogen biosynthetic process (GO:0045725)2.18516394
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.17615484
64negative regulation of neurotransmitter secretion (GO:0046929)2.16822269
65relaxation of cardiac muscle (GO:0055119)2.16584354
66carnitine shuttle (GO:0006853)2.16069681
67regulation of short-term neuronal synaptic plasticity (GO:0048172)2.15944997
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.15389541
69valine metabolic process (GO:0006573)2.14556035
70response to epinephrine (GO:0071871)2.14394206
71positive regulation of endothelial cell apoptotic process (GO:2000353)2.14285558
72retrograde transport, vesicle recycling within Golgi (GO:0000301)2.14219170
73protein targeting to Golgi (GO:0000042)2.14064519
74negative regulation of T cell mediated immunity (GO:0002710)2.13935600
75locomotory exploration behavior (GO:0035641)2.13000726
76positive regulation of gamma-delta T cell activation (GO:0046645)2.11771795
77B cell receptor signaling pathway (GO:0050853)2.10743506
78response to nerve growth factor (GO:1990089)2.08949061
79cellular response to nerve growth factor stimulus (GO:1990090)2.08949061
80regulation of beta-amyloid formation (GO:1902003)2.08116869
81germinal center formation (GO:0002467)2.07954279
82regulation of ARF protein signal transduction (GO:0032012)2.07571649
83JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.07375419
84cellular sodium ion homeostasis (GO:0006883)2.05882218
85cellular response to monoamine stimulus (GO:0071868)2.03754647
86cellular response to catecholamine stimulus (GO:0071870)2.03754647
87regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.03353481
88clathrin coat assembly (GO:0048268)2.03177655
89peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.02730341
90dendrite morphogenesis (GO:0048813)2.01549006
91positive regulation of lipid catabolic process (GO:0050996)2.00885079
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.00835244
93regulation of fatty acid beta-oxidation (GO:0031998)2.00322145
94* insulin-like growth factor receptor signaling pathway (GO:0048009)2.00219798
95nucleus localization (GO:0051647)1.99320861
96neurotransmitter secretion (GO:0007269)1.98960739
97layer formation in cerebral cortex (GO:0021819)1.98592649
98exploration behavior (GO:0035640)1.98419379
99negative regulation of cell killing (GO:0031342)1.98152421
100negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.98152421
101regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.97700485
102positive regulation of phosphoprotein phosphatase activity (GO:0032516)1.97256418
103gamma-aminobutyric acid signaling pathway (GO:0007214)1.96463486
104activation of protein kinase A activity (GO:0034199)1.96208501
105regulation of triglyceride catabolic process (GO:0010896)1.95629381
106postsynaptic membrane organization (GO:0001941)1.95012285
107heart field specification (GO:0003128)1.94701656
108secondary heart field specification (GO:0003139)1.94701656
109regulation of female receptivity (GO:0045924)1.94204999
110negative regulation of lymphocyte mediated immunity (GO:0002707)1.93837876
111positive regulation of p38MAPK cascade (GO:1900745)1.93796332
112regulation of interleukin-12 biosynthetic process (GO:0045075)1.93741709
113regulation of neuronal synaptic plasticity (GO:0048168)1.93718270
114T cell migration (GO:0072678)1.92983770
115negative regulation of type 2 immune response (GO:0002829)1.91448115
116cell communication involved in cardiac conduction (GO:0086065)1.91229735
117low-density lipoprotein particle clearance (GO:0034383)1.91165880
118potassium ion homeostasis (GO:0055075)1.91134637
119negative regulation of leukocyte mediated immunity (GO:0002704)1.90865189
120histone lysine demethylation (GO:0070076)1.90778524
121embryonic retina morphogenesis in camera-type eye (GO:0060059)1.90403095
122triglyceride catabolic process (GO:0019433)1.89440061
123regulation of histone deacetylation (GO:0031063)1.88367517
124neutral lipid catabolic process (GO:0046461)1.85613021
125acylglycerol catabolic process (GO:0046464)1.85613021
126intracellular lipid transport (GO:0032365)1.85586843
127positive regulation of glycogen metabolic process (GO:0070875)1.85448256
128presynaptic membrane assembly (GO:0097105)1.85285053
129phospholipid homeostasis (GO:0055091)1.83753771
130positive regulation of natural killer cell differentiation (GO:0032825)1.83499178
131positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.83086249
132regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act1.82421039
133proline transport (GO:0015824)1.82279261
134regulation of glycogen (starch) synthase activity (GO:2000465)1.82225285
135histone H3-K36 demethylation (GO:0070544)1.81206843
136antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.79574920
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.79574920
138negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)1.78699497
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.78547427
140negative regulation of protein autophosphorylation (GO:0031953)1.77288885
141regulation of gamma-delta T cell differentiation (GO:0045586)1.76905703
142negative regulation of lipid storage (GO:0010888)1.76205907
143membrane assembly (GO:0071709)1.76135696
144response to interleukin-15 (GO:0070672)1.75322894
145positive regulation of cardiac muscle hypertrophy (GO:0010613)1.73046557
146positive regulation of muscle hypertrophy (GO:0014742)1.73046557
147Golgi to endosome transport (GO:0006895)1.72689236
148cellular response to prostaglandin stimulus (GO:0071379)1.72401601
149regulation of fatty acid oxidation (GO:0046320)1.72140085
150regulation of p38MAPK cascade (GO:1900744)1.71543226
151negative regulation of fatty acid transport (GO:2000192)1.71496650
152establishment of nucleus localization (GO:0040023)1.71259928
153regulation of cholesterol storage (GO:0010885)1.69410702
154regulation of lipid catabolic process (GO:0050994)1.68615126
155regulation of ARF GTPase activity (GO:0032312)1.67986090
156cellular response to cholesterol (GO:0071397)1.67256129
157regulation of glutamate receptor signaling pathway (GO:1900449)1.67088046
158phospholipid translocation (GO:0045332)1.66320563
159lipid translocation (GO:0034204)1.66320563
160* positive regulation of glucose import (GO:0046326)1.65747149
161dendritic spine morphogenesis (GO:0060997)1.65558033
162macroautophagy (GO:0016236)1.65519425
163positive regulation of macrophage cytokine production (GO:0060907)1.65244198
164antigen processing and presentation of endogenous antigen (GO:0019883)1.65225080
165positive regulation of synaptic transmission, glutamatergic (GO:0051968)1.64021237
166regulation of gamma-delta T cell activation (GO:0046643)1.63994784
167vocalization behavior (GO:0071625)1.63897086
168serine transport (GO:0032329)1.63742631
169brown fat cell differentiation (GO:0050873)1.63616847
170glutamate secretion (GO:0014047)1.63082316
171regulation of synapse structural plasticity (GO:0051823)1.62429620
172fatty-acyl-CoA biosynthetic process (GO:0046949)1.62189882
173neurotransmitter-gated ion channel clustering (GO:0072578)1.62185207
174glycine transport (GO:0015816)1.61380654
175alanine transport (GO:0032328)1.61361791
176positive regulation of cholesterol efflux (GO:0010875)1.61047727
177lipid storage (GO:0019915)1.60836241
178cellular extravasation (GO:0045123)1.60592419
179cortical actin cytoskeleton organization (GO:0030866)1.60336417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.33726834
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23193469
3SMAD_19615063_ChIP-ChIP_OVARY_Human1.98282044
4GBX2_23144817_ChIP-Seq_PC3_Human1.92091339
5AR_21572438_ChIP-Seq_LNCaP_Human1.90809925
6* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82177998
7CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78884675
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72916422
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71611698
10* RUNX_20019798_ChIP-Seq_JUKART_Human1.63713313
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61675317
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57894412
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55138118
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.52087772
15* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51886496
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.51325216
17DROSHA_22980978_ChIP-Seq_HELA_Human1.50042946
18* GATA2_21666600_ChIP-Seq_HMVEC_Human1.44492990
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44215399
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44215399
21MTF2_20144788_ChIP-Seq_MESCs_Mouse1.43357241
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41826150
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40267704
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40147901
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39408671
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38307036
27* RARB_27405468_Chip-Seq_BRAIN_Mouse1.35380307
28* AHR_22903824_ChIP-Seq_MCF-7_Human1.34691193
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34083445
30EZH2_22144423_ChIP-Seq_EOC_Human1.33414218
31* LXR_22158963_ChIP-Seq_LIVER_Mouse1.32452869
32* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32090079
33GATA1_22025678_ChIP-Seq_K562_Human1.32060502
34* PIAS1_25552417_ChIP-Seq_VCAP_Human1.31760552
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.31657818
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29646244
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29277156
38* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28078181
39* ARNT_22903824_ChIP-Seq_MCF-7_Human1.28064756
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27786597
41RXR_22108803_ChIP-Seq_LS180_Human1.26446771
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.23831083
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.23797973
44NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22333681
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22333681
46VDR_24787735_ChIP-Seq_THP-1_Human1.21803243
47TCF7_22412390_ChIP-Seq_EML_Mouse1.20928801
48* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20065972
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.19548048
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19154470
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.17845091
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.17268331
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15644212
54TP53_16413492_ChIP-PET_HCT116_Human1.15407729
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.14551857
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.14323944
57* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13821132
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13663745
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13431363
60* RXR_22158963_ChIP-Seq_LIVER_Mouse1.12191447
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.11326713
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.11286680
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11045959
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.10847497
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09549101
66CJUN_26792858_Chip-Seq_BT549_Human1.09018239
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07506579
68* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07355234
69REST_21632747_ChIP-Seq_MESCs_Mouse1.07277992
70* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07172939
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06732129
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06428442
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.06051104
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.05745374
75* KDM2B_26808549_Chip-Seq_DND41_Human1.04582240
76ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03988459
77TCF4_18268006_ChIP-ChIP_LS174T_Human1.03975950
78* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03685435
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02863167
80* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02834635
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.02723146
82CLOCK_20551151_ChIP-Seq_293T_Human1.02409734
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02390032
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02363110
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.02282712
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02089718
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.01514887
88* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01100104
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.00564151
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99553741
91WT1_19549856_ChIP-ChIP_CCG9911_Human0.99398902
92* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99242527
93* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98293410
94TP53_18474530_ChIP-ChIP_U2OS_Human0.97902285
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97596663
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97373460
97* SCL_19346495_ChIP-Seq_HPC-7_Human0.97182124
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96470296
99* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96267477
100* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96114886
101EZH2_27294783_Chip-Seq_ESCs_Mouse0.95579117
102SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94699538
103* AR_25329375_ChIP-Seq_VCAP_Human0.93490155
104* P300_19829295_ChIP-Seq_ESCs_Human0.93252222
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92989017
106* GATA2_19941826_ChIP-Seq_K562_Human0.92495786
107* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.91931880
108STAT3_23295773_ChIP-Seq_U87_Human0.91278591
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91161636
110SPI1_23127762_ChIP-Seq_K562_Human0.91157516
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90995574
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90389350
113* KDM2B_26808549_Chip-Seq_K562_Human0.90359068
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89724348
115IRF8_27001747_Chip-Seq_BMDM_Mouse0.89670508
116TBX20_22080862_ChIP-Seq_HEART_Mouse0.89030739
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.89030739
118BCAT_22108803_ChIP-Seq_LS180_Human0.88920244
119SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88396386
120TAF15_26573619_Chip-Seq_HEK293_Human0.88377539
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.88052714
122* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87588806
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87419157
124* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85136054
125DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84780463
126GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84507158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.23641545
2* MP0004130_abnormal_muscle_cell2.76755600
3MP0000569_abnormal_digit_pigmentation2.76282801
4MP0003300_gastrointestinal_ulcer2.70161664
5MP0003880_abnormal_central_pattern2.31738592
6MP0003763_abnormal_thymus_physiology2.30628065
7MP0003045_fibrosis2.21016582
8MP0005423_abnormal_somatic_nervous2.16044926
9MP0004185_abnormal_adipocyte_glucose2.09742322
10MP0004859_abnormal_synaptic_plasticity2.03510197
11MP0003329_amyloid_beta_deposits2.02033195
12MP0001851_eye_inflammation2.00670618
13MP0002064_seizures1.96533691
14MP0000465_gastrointestinal_hemorrhage1.83370717
15MP0005670_abnormal_white_adipose1.79085332
16MP0002166_altered_tumor_susceptibility1.77534721
17MP0005409_darkened_coat_color1.77235678
18MP0008438_abnormal_cutaneous_collagen1.76337769
19MP0002254_reproductive_system_inflammat1.73914322
20MP0010329_abnormal_lipoprotein_level1.73571539
21MP0010234_abnormal_vibrissa_follicle1.73403041
22* MP0005666_abnormal_adipose_tissue1.68754138
23MP0009745_abnormal_behavioral_response1.65573712
24MP0003690_abnormal_glial_cell1.65106867
25MP0001486_abnormal_startle_reflex1.62458956
26MP0002009_preneoplasia1.60003616
27MP0003303_peritoneal_inflammation1.59553532
28MP0002837_dystrophic_cardiac_calcinosis1.56803654
29MP0005365_abnormal_bile_salt1.51514519
30MP0001881_abnormal_mammary_gland1.50630195
31MP0003879_abnormal_hair_cell1.49109578
32MP0003252_abnormal_bile_duct1.39606117
33MP0003183_abnormal_peptide_metabolism1.39196186
34MP0004510_myositis1.37474578
35MP0002998_abnormal_bone_remodeling1.36422228
36* MP0005375_adipose_tissue_phenotype1.33844082
37MP0001440_abnormal_grooming_behavior1.30910200
38MP0002006_tumorigenesis1.30703906
39MP0002272_abnormal_nervous_system1.29842865
40MP0004270_analgesia1.28103092
41* MP0001800_abnormal_humoral_immune1.27698585
42MP0000920_abnormal_myelination1.26961184
43* MP0002118_abnormal_lipid_homeostasis1.25627679
44MP0001958_emphysema1.24930990
45MP0003868_abnormal_feces_composition1.24564318
46MP0001835_abnormal_antigen_presentation1.23268857
47MP0004036_abnormal_muscle_relaxation1.22448205
48MP0003705_abnormal_hypodermis_morpholog1.22160731
49MP0002572_abnormal_emotion/affect_behav1.20834208
50MP0004883_abnormal_blood_vessel1.20045064
51MP0002909_abnormal_adrenal_gland1.17234395
52MP0003631_nervous_system_phenotype1.16803963
53MP0008961_abnormal_basal_metabolism1.15607873
54MP0006082_CNS_inflammation1.15317582
55MP0005275_abnormal_skin_tensile1.14733836
56* MP0005334_abnormal_fat_pad1.13566862
57MP0001873_stomach_inflammation1.13443716
58MP0004084_abnormal_cardiac_muscle1.12023998
59MP0004381_abnormal_hair_follicle1.11956572
60MP0002971_abnormal_brown_adipose1.11787928
61MP0000003_abnormal_adipose_tissue1.10355275
62MP0008569_lethality_at_weaning1.09810326
63MP0002139_abnormal_hepatobiliary_system1.09268355
64MP0003091_abnormal_cell_migration1.07787245
65MP0005535_abnormal_body_temperature1.07054151
66MP0005166_decreased_susceptibility_to1.06826877
67MP0005671_abnormal_response_to1.06236334
68MP0003633_abnormal_nervous_system1.06103897
69MP0005187_abnormal_penis_morphology1.05814120
70MP0003279_aneurysm1.05417159
71MP0003635_abnormal_synaptic_transmissio1.05384487
72MP0003866_abnormal_defecation1.05359594
73MP0003075_altered_response_to1.03876585
74MP0005464_abnormal_platelet_physiology1.02826689
75MP0000579_abnormal_nail_morphology1.02179282
76MP0009384_cardiac_valve_regurgitation1.01340948
77MP0004858_abnormal_nervous_system1.00723705
78MP0002133_abnormal_respiratory_system1.00216446
79MP0005388_respiratory_system_phenotype1.00216446
80MP0002723_abnormal_immune_serum0.99856166
81MP0003191_abnormal_cellular_cholesterol0.99809786
82MP0000013_abnormal_adipose_tissue0.99699820
83MP0009046_muscle_twitch0.99182133
84MP0002734_abnormal_mechanical_nocicepti0.97216520
85MP0003632_abnormal_nervous_system0.96894397
86MP0002896_abnormal_bone_mineralization0.96195467
87MP0001879_abnormal_lymphatic_vessel0.95391017
88* MP0005025_abnormal_response_to0.95212714
89* MP0002420_abnormal_adaptive_immunity0.95020215
90MP0003787_abnormal_imprinting0.94809161
91MP0003634_abnormal_glial_cell0.94541166
92MP0000751_myopathy0.94474921
93MP0001501_abnormal_sleep_pattern0.94181559
94MP0006138_congestive_heart_failure0.93602664
95MP0002933_joint_inflammation0.93014351
96MP0002877_abnormal_melanocyte_morpholog0.92522225
97MP0004885_abnormal_endolymph0.92138282
98* MP0001819_abnormal_immune_cell0.92117182
99MP0002067_abnormal_sensory_capabilities0.91891773
100MP0005085_abnormal_gallbladder_physiolo0.90231985
101MP0005386_behavior/neurological_phenoty0.89800471
102MP0004924_abnormal_behavior0.89800471
103MP0002876_abnormal_thyroid_physiology0.89482727
104MP0003724_increased_susceptibility_to0.89473294
105MP0001533_abnormal_skeleton_physiology0.88423772
106MP0002168_other_aberrant_phenotype0.88384492
107MP0001790_abnormal_immune_system0.88073560
108MP0005387_immune_system_phenotype0.88073560
109MP0000249_abnormal_blood_vessel0.86056606
110MP0009278_abnormal_bone_marrow0.85977315
111MP0005167_abnormal_blood-brain_barrier0.85556570
112MP0002332_abnormal_exercise_endurance0.84798946
113MP0000609_abnormal_liver_physiology0.84715078
114MP0008775_abnormal_heart_ventricle0.84380548
115MP0001299_abnormal_eye_distance/0.84065922
116MP0002972_abnormal_cardiac_muscle0.82590223
117MP0001348_abnormal_lacrimal_gland0.81823185
118* MP0002452_abnormal_antigen_presenting0.80880948
119MP0004484_altered_response_of0.80693508
120MP0002419_abnormal_innate_immunity0.78717857
121MP0010678_abnormal_skin_adnexa0.77950813
122MP0004147_increased_porphyrin_level0.77463933
123MP0002735_abnormal_chemical_nociception0.77451850
124MP0002063_abnormal_learning/memory/cond0.76484578
125MP0008004_abnormal_stomach_pH0.76429309
126MP0005360_urolithiasis0.75807543
127MP0000685_abnormal_immune_system0.75759861
128MP0001666_abnormal_nutrient_absorption0.72152818
129* MP0009115_abnormal_fat_cell0.71626176
130MP0001502_abnormal_circadian_rhythm0.71020031
131MP0003828_pulmonary_edema0.70660258
132MP0003436_decreased_susceptibility_to0.70551690
133MP0005248_abnormal_Harderian_gland0.69390620
134MP0005448_abnormal_energy_balance0.69315931
135MP0001177_atelectasis0.68252019
136MP0010368_abnormal_lymphatic_system0.67849560
137* MP0002078_abnormal_glucose_homeostasis0.67029247
138MP0000604_amyloidosis0.66677508
139MP0005000_abnormal_immune_tolerance0.66570688
140MP0002060_abnormal_skin_morphology0.66528708
141MP0000230_abnormal_systemic_arterial0.66446924
142MP0008874_decreased_physiological_sensi0.66383967
143MP0005620_abnormal_muscle_contractility0.65474986
144MP0004947_skin_inflammation0.65178126
145MP0005385_cardiovascular_system_phenoty0.64824024
146MP0001544_abnormal_cardiovascular_syste0.64824024
147MP0003172_abnormal_lysosome_physiology0.64632048
148MP0005584_abnormal_enzyme/coenzyme_acti0.64454470
149MP0004272_abnormal_basement_membrane0.64028015

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)3.98326598
2Autoimmune hemolytic anemia (HP:0001890)3.93620591
3Neonatal hypoglycemia (HP:0001998)3.85212322
4Diplopia (HP:0000651)3.27343052
5Abnormality of binocular vision (HP:0011514)3.27343052
6Abnormality of T cell number (HP:0011839)3.22171463
7Febrile seizures (HP:0002373)3.06124802
8Focal motor seizures (HP:0011153)2.92320236
9Macroorchidism (HP:0000053)2.87342514
10Eczematoid dermatitis (HP:0000976)2.77150823
11Eosinophilia (HP:0001880)2.73758705
12Broad metatarsal (HP:0001783)2.72291704
13Atonic seizures (HP:0010819)2.62731175
14Hematochezia (HP:0002573)2.54904459
15Aortic aneurysm (HP:0004942)2.51593201
16Focal seizures (HP:0007359)2.50322847
17Increased IgM level (HP:0003496)2.47878732
18Action tremor (HP:0002345)2.42791083
19Postural instability (HP:0002172)2.42539746
20Spontaneous hematomas (HP:0007420)2.40975621
21Buphthalmos (HP:0000557)2.40299716
22Granulocytopenia (HP:0001913)2.36141573
23Lip pit (HP:0100267)2.33347813
24Truncal ataxia (HP:0002078)2.29744070
25Progressive cerebellar ataxia (HP:0002073)2.28986316
26Abnormality of eosinophils (HP:0001879)2.28062213
27Myokymia (HP:0002411)2.27774485
28Abnormality of the columella (HP:0009929)2.23687384
29Ankle clonus (HP:0011448)2.22142961
30Complement deficiency (HP:0004431)2.21062591
31Sudden death (HP:0001699)2.19278874
32Recurrent gram-negative bacterial infections (HP:0005420)2.18730815
33Narrow palate (HP:0000189)2.15340331
34Hypochromic anemia (HP:0001931)2.13188871
35Slow saccadic eye movements (HP:0000514)2.11241184
36Enlarged penis (HP:0000040)2.09923411
37T lymphocytopenia (HP:0005403)2.08701233
38Bundle branch block (HP:0011710)2.08673018
39Scanning speech (HP:0002168)2.05397989
40Shallow orbits (HP:0000586)2.02006487
41Myocardial infarction (HP:0001658)2.01963720
42Overgrowth (HP:0001548)2.00654735
43Muscle fiber splitting (HP:0003555)1.99554266
44Pigmentary retinal degeneration (HP:0001146)1.98627168
45Hypoplastic ischia (HP:0003175)1.97398298
46Sparse lateral eyebrow (HP:0005338)1.97038041
47Striae distensae (HP:0001065)1.96589212
48Leukocytosis (HP:0001974)1.95671538
49Abnormal eating behavior (HP:0100738)1.92935270
50Insidious onset (HP:0003587)1.92934288
51Termporal pattern (HP:0011008)1.92934288
52Abnormality of the left ventricular outflow tract (HP:0011103)1.92211847
53Subaortic stenosis (HP:0001682)1.92211847
54Exostoses (HP:0100777)1.91962191
55Lymphangioma (HP:0100764)1.91628812
56Abnormality of the ischium (HP:0003174)1.91530888
57Abnormality of complement system (HP:0005339)1.90357301
58Gingivitis (HP:0000230)1.88726509
59Absent frontal sinuses (HP:0002688)1.88451188
60Aortic dissection (HP:0002647)1.87925061
61Deep venous thrombosis (HP:0002625)1.87197724
62Intention tremor (HP:0002080)1.86322327
63Mitral valve prolapse (HP:0001634)1.86180646
64Vasculitis (HP:0002633)1.84218322
65Spastic gait (HP:0002064)1.83916202
66Excessive salivation (HP:0003781)1.83256116
67Drooling (HP:0002307)1.83256116
68Mutism (HP:0002300)1.83021425
69Subcapsular cataract (HP:0000523)1.82781659
70Epidermoid cyst (HP:0200040)1.81834539
71Abnormal social behavior (HP:0012433)1.80826551
72Impaired social interactions (HP:0000735)1.80826551
73Arterial thrombosis (HP:0004420)1.80741589
74Inappropriate behavior (HP:0000719)1.80315487
75Abnormality of the fingertips (HP:0001211)1.79517189
76Oligomenorrhea (HP:0000876)1.79461839
77Myositis (HP:0100614)1.78112426
78Lower limb muscle weakness (HP:0007340)1.77829552
79Hemorrhage of the eye (HP:0011885)1.77783501
80Retrobulbar optic neuritis (HP:0100654)1.76095787
81Optic neuritis (HP:0100653)1.76095787
82Annular pancreas (HP:0001734)1.75560178
83Hyporeflexia of lower limbs (HP:0002600)1.73649432
84Mask-like facies (HP:0000298)1.73298206
85Accelerated skeletal maturation (HP:0005616)1.72890511
86Systemic lupus erythematosus (HP:0002725)1.72499510
87Poor eye contact (HP:0000817)1.72086415
88Cerebral aneurysm (HP:0004944)1.71699521
89Papilledema (HP:0001085)1.71485990
90Arterial tortuosity (HP:0005116)1.71118883
91Abnormality of the nasal septum (HP:0000419)1.70409092
92Supranuclear gaze palsy (HP:0000605)1.70178286
93Lower limb amyotrophy (HP:0007210)1.69160344
94EMG: neuropathic changes (HP:0003445)1.68740838
95Subacute progressive viral hepatitis (HP:0006572)1.67914078
96Turricephaly (HP:0000262)1.67779704
97Gingival bleeding (HP:0000225)1.67632075
98Fatigue (HP:0012378)1.67006219
99Syncope (HP:0001279)1.66622395
100Genetic anticipation (HP:0003743)1.66125479
101Vascular tortuosity (HP:0004948)1.65679999
102Colitis (HP:0002583)1.65387512
103Dysdiadochokinesis (HP:0002075)1.65218568
104Aneurysm (HP:0002617)1.64998221
105Germ cell neoplasia (HP:0100728)1.64569372
106Orchitis (HP:0100796)1.63776600
107Depressed nasal tip (HP:0000437)1.63600126
108Vertigo (HP:0002321)1.63434131
109Asymmetric septal hypertrophy (HP:0001670)1.63296551
110Disinhibition (HP:0000734)1.62553082
111Pulmonary embolism (HP:0002204)1.62174063
112Neuronal loss in central nervous system (HP:0002529)1.61846403
113Peripheral hypomyelination (HP:0007182)1.61260178
114Atrioventricular block (HP:0001678)1.60948991
115Prolonged bleeding time (HP:0003010)1.60174429
116Bone cyst (HP:0012062)1.58983189
117Urinary bladder sphincter dysfunction (HP:0002839)1.58924698
118Abnormality of the corticospinal tract (HP:0002492)1.58684095
119Neoplasm of the tracheobronchial system (HP:0100552)1.58590063
120Mitral stenosis (HP:0001718)1.58577100
121Abnormality of T cells (HP:0002843)1.58010925
122Absence seizures (HP:0002121)1.57961940
123Dysmetria (HP:0001310)1.57275139
124Neoplasm of the heart (HP:0100544)1.56684080
125Milia (HP:0001056)1.56649190
126Obstructive sleep apnea (HP:0002870)1.56606803
127Stereotypic behavior (HP:0000733)1.56375127
128Papillary thyroid carcinoma (HP:0002895)1.55269574
129Open mouth (HP:0000194)1.55067680
130Asymmetry of the thorax (HP:0001555)1.54760513
131Neurofibrillary tangles (HP:0002185)1.54760141
132Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54460280
133Aqueductal stenosis (HP:0002410)1.53961539
134Nephritis (HP:0000123)1.53727013
135Periodontitis (HP:0000704)1.53674104
136Right ventricular cardiomyopathy (HP:0011663)1.53440937
137Difficulty running (HP:0009046)1.52777134
138Hyperlipoproteinemia (HP:0010980)1.52585499
139Epistaxis (HP:0000421)1.52413497
140Abnormality of the 4th metacarpal (HP:0010012)1.52357103
141Abnormality of saccadic eye movements (HP:0000570)1.52174270
142Blue irides (HP:0000635)1.51881005
143Amyloidosis (HP:0011034)1.51857879
144Increased cerebral lipofuscin (HP:0011813)1.51703265
145Dysmetric saccades (HP:0000641)1.51698283
146Hemangiomatosis (HP:0007461)1.51577387
147Abnormality of the periventricular white matter (HP:0002518)1.51471552
148Keratoconjunctivitis sicca (HP:0001097)1.50840380
149Visceral angiomatosis (HP:0100761)1.50782625
150Abnormal delayed hypersensitivity skin test (HP:0002963)1.49479687
151Lower limb asymmetry (HP:0100559)1.49301156
152Atrophic scars (HP:0001075)1.47578524
153Hemiplegia (HP:0002301)1.46919756
154Exotropia (HP:0000577)1.46618475
155Acanthosis nigricans (HP:0000956)1.45571623
156Infantile muscular hypotonia (HP:0008947)1.45182486
157Vitreoretinal degeneration (HP:0000655)1.44091699
158Broad-based gait (HP:0002136)1.43113835
159Hyperventilation (HP:0002883)1.42492247
160Abnormality of the common coagulation pathway (HP:0010990)1.42077483
161Onion bulb formation (HP:0003383)1.41543715
162Ketoacidosis (HP:0001993)1.40533479
163Cerebral inclusion bodies (HP:0100314)1.40117012
164Torticollis (HP:0000473)1.39916399
165Scapular winging (HP:0003691)1.39483240
166Epileptic encephalopathy (HP:0200134)1.39123932
167Stomach cancer (HP:0012126)1.38510219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK13.29125430
2PRPF4B2.77888685
3CAMK1D2.66980028
4CAMK1G2.48475985
5MARK12.31778008
6FRK2.13621935
7TRIB31.95229615
8FGFR21.87235146
9FES1.86426784
10FGFR31.76829158
11LATS11.73087362
12TAOK31.70554440
13JAK11.70205718
14RIPK11.67843566
15BMPR21.62055499
16TGFBR21.47061574
17LMTK21.46896944
18EPHB11.45420043
19EPHA31.43052094
20INSRR1.42101620
21DAPK21.36690904
22KIT1.33920630
23DMPK1.32982978
24PIK3CG1.30263300
25AKT31.27950864
26PHKG11.27306825
27PHKG21.27306825
28UHMK11.22488089
29MAP3K131.22095060
30SGK31.20043235
31MAP3K141.19257487
32ZAP701.18592789
33CDK121.18252481
34FGFR41.17610692
35MAP3K21.17398363
36JAK31.16755705
37TXK1.15594618
38SIK21.13805937
39TNK21.12553093
40MAP4K11.12249200
41PKN21.09176091
42TLK11.07814140
43SYK1.03463064
44NEK61.02969387
45PRKCH1.02128140
46PKN11.02010585
47MAPK121.01631799
48RIPK41.01350651
49CSF1R0.99223599
50SGK20.98771667
51BTK0.98037585
52TYRO30.97497843
53MARK20.97427816
54* RET0.95904464
55JAK20.94411768
56MAP2K30.93545217
57PRKAA20.89825799
58FLT30.88984948
59IKBKE0.88233699
60MAP3K70.87911040
61PDGFRA0.87582697
62MAP3K90.86152355
63NLK0.85396191
64BLK0.85204294
65GRK60.84136766
66SGK4940.82992194
67SGK2230.82992194
68TTN0.82005594
69CAMKK10.81830334
70CDK190.81545170
71TYK20.81133842
72NTRK10.77435356
73CASK0.77294072
74PTK60.76169282
75CSK0.74853360
76TNIK0.74152039
77STK380.73616137
78TEC0.73399709
79MAP3K40.72446174
80CHUK0.71939935
81PDK10.70971953
82MAP3K10.70245834
83PDPK10.65868541
84* LCK0.64906881
85NUAK10.64386742
86MAP3K60.64123692
87CDC42BPA0.64012641
88HIPK20.63847206
89MAPK70.63646846
90TAOK10.63234107
91MINK10.62828087
92STK110.62062048
93* PDGFRB0.61377735
94NTRK20.59831103
95MAP2K40.59327341
96MAPK40.59187278
97TBK10.58632806
98PAK60.58176424
99OBSCN0.58152072
100PRKD30.57745710
101MOS0.57658880
102DYRK1A0.57491911
103PRKAA10.56837984
104CAMKK20.56169374
105MAPK100.55956587
106CDK50.55744914
107SGK10.55034895
108WNK10.54210242
109PAK30.54205090
110CAMK10.54125010
111GRK50.53510912
112MAPK130.52655106
113ERBB20.52527611
114GRK70.51396871
115ERN10.51192667
116CAMK40.51115202
117GSK3A0.50994790
118ITK0.50536331
119EPHA40.50514914
120MAP3K100.50246290
121PRKCE0.49583520
122IRAK20.49414554
123EEF2K0.48744834
124DDR20.48575379
125TRPM70.48567502
126BMX0.48527566
127NTRK30.48097934
128* PRKD10.47191719
129* FYN0.47189936
130KSR20.47008016
131HCK0.44302209
132IRAK10.43853043
133PRKCQ0.43328294
134PRKCZ0.42989231
135CDK90.42408727

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.58497684
2* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.93071925
3Fatty acid biosynthesis_Homo sapiens_hsa000611.71206581
4Caffeine metabolism_Homo sapiens_hsa002321.53445038
5Amphetamine addiction_Homo sapiens_hsa050311.37034096
6Nicotine addiction_Homo sapiens_hsa050331.32064208
7* Type II diabetes mellitus_Homo sapiens_hsa049301.28524857
8PPAR signaling pathway_Homo sapiens_hsa033201.24053344
9Renin secretion_Homo sapiens_hsa049241.20746354
10* Insulin resistance_Homo sapiens_hsa049311.10265079
11African trypanosomiasis_Homo sapiens_hsa051431.10137520
12* Osteoclast differentiation_Homo sapiens_hsa043801.06670129
13Adipocytokine signaling pathway_Homo sapiens_hsa049201.04699891
14Inositol phosphate metabolism_Homo sapiens_hsa005621.03001897
15Fatty acid metabolism_Homo sapiens_hsa012121.01360752
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00461952
17Vascular smooth muscle contraction_Homo sapiens_hsa042700.97338618
18Circadian rhythm_Homo sapiens_hsa047100.97245053
19Calcium signaling pathway_Homo sapiens_hsa040200.96749391
20Salivary secretion_Homo sapiens_hsa049700.95742846
21* Non-small cell lung cancer_Homo sapiens_hsa052230.95469158
22Circadian entrainment_Homo sapiens_hsa047130.94347201
23Staphylococcus aureus infection_Homo sapiens_hsa051500.93930078
24* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93578335
25* Prolactin signaling pathway_Homo sapiens_hsa049170.93459108
26* VEGF signaling pathway_Homo sapiens_hsa043700.92503731
27* Platelet activation_Homo sapiens_hsa046110.92399773
28Gastric acid secretion_Homo sapiens_hsa049710.91625942
29Dorso-ventral axis formation_Homo sapiens_hsa043200.91189402
30Propanoate metabolism_Homo sapiens_hsa006400.89372366
31Long-term depression_Homo sapiens_hsa047300.89357478
32* B cell receptor signaling pathway_Homo sapiens_hsa046620.89166731
33Fatty acid degradation_Homo sapiens_hsa000710.87574864
34Cocaine addiction_Homo sapiens_hsa050300.87491671
35* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87398331
36Graft-versus-host disease_Homo sapiens_hsa053320.86847138
37* FoxO signaling pathway_Homo sapiens_hsa040680.86383326
38* Cholinergic synapse_Homo sapiens_hsa047250.86318830
39* Toxoplasmosis_Homo sapiens_hsa051450.85694134
40* AMPK signaling pathway_Homo sapiens_hsa041520.83650585
41* Focal adhesion_Homo sapiens_hsa045100.82998692
42* cAMP signaling pathway_Homo sapiens_hsa040240.82917500
43Dilated cardiomyopathy_Homo sapiens_hsa054140.82003093
44* Pancreatic cancer_Homo sapiens_hsa052120.81811403
45* Chemokine signaling pathway_Homo sapiens_hsa040620.81784948
46Prion diseases_Homo sapiens_hsa050200.81249361
47Olfactory transduction_Homo sapiens_hsa047400.81151697
48Leishmaniasis_Homo sapiens_hsa051400.80977148
49Allograft rejection_Homo sapiens_hsa053300.80598653
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80479910
51* Insulin signaling pathway_Homo sapiens_hsa049100.79509903
52ECM-receptor interaction_Homo sapiens_hsa045120.78193396
53* Neurotrophin signaling pathway_Homo sapiens_hsa047220.77650574
54Autoimmune thyroid disease_Homo sapiens_hsa053200.77547986
55* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77220632
56* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76788494
57Morphine addiction_Homo sapiens_hsa050320.76587002
58Glutamatergic synapse_Homo sapiens_hsa047240.76213337
59Synaptic vesicle cycle_Homo sapiens_hsa047210.75771859
60* T cell receptor signaling pathway_Homo sapiens_hsa046600.75598065
61* Glioma_Homo sapiens_hsa052140.75510806
62* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75007359
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74653868
64* Oxytocin signaling pathway_Homo sapiens_hsa049210.74603494
65* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73946593
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73883005
67Pancreatic secretion_Homo sapiens_hsa049720.73075641
68Viral myocarditis_Homo sapiens_hsa054160.72769560
69* Sphingolipid signaling pathway_Homo sapiens_hsa040710.72752402
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72719668
71* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71746214
72Axon guidance_Homo sapiens_hsa043600.71473833
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71461361
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71399173
75Malaria_Homo sapiens_hsa051440.71174826
76Gap junction_Homo sapiens_hsa045400.71091345
77* Ras signaling pathway_Homo sapiens_hsa040140.70962746
78* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70181152
79Long-term potentiation_Homo sapiens_hsa047200.69603694
80* Endometrial cancer_Homo sapiens_hsa052130.69204702
81* ErbB signaling pathway_Homo sapiens_hsa040120.68649768
82* Amoebiasis_Homo sapiens_hsa051460.68557435
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68528908
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68490722
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67307638
86* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67253479
87* Estrogen signaling pathway_Homo sapiens_hsa049150.66729701
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66284976
89* Rap1 signaling pathway_Homo sapiens_hsa040150.65326442
90* Renal cell carcinoma_Homo sapiens_hsa052110.65302251
91* Acute myeloid leukemia_Homo sapiens_hsa052210.65298585
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65196353
93* Measles_Homo sapiens_hsa051620.64821797
94GnRH signaling pathway_Homo sapiens_hsa049120.64814647
95Insulin secretion_Homo sapiens_hsa049110.64392264
96Bile secretion_Homo sapiens_hsa049760.64360789
97* Leukocyte transendothelial migration_Homo sapiens_hsa046700.64064422
98ABC transporters_Homo sapiens_hsa020100.63830734
99GABAergic synapse_Homo sapiens_hsa047270.63637528
100* Jak-STAT signaling pathway_Homo sapiens_hsa046300.63399582
101Lysine degradation_Homo sapiens_hsa003100.63226808
102* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61531566
103* Chronic myeloid leukemia_Homo sapiens_hsa052200.61500678
104* Phospholipase D signaling pathway_Homo sapiens_hsa040720.60332074
105Butanoate metabolism_Homo sapiens_hsa006500.59391989
106Complement and coagulation cascades_Homo sapiens_hsa046100.59314377
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58912830
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58878684
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.58299175
110Arginine biosynthesis_Homo sapiens_hsa002200.58180022
111Serotonergic synapse_Homo sapiens_hsa047260.57403981
112Dopaminergic synapse_Homo sapiens_hsa047280.57307735
113Pertussis_Homo sapiens_hsa051330.56850924
114MAPK signaling pathway_Homo sapiens_hsa040100.56559754
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56489355
116* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56197285
117Glycerolipid metabolism_Homo sapiens_hsa005610.56186517
118* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56185041
119* mTOR signaling pathway_Homo sapiens_hsa041500.56178714
120* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56106095
121* TNF signaling pathway_Homo sapiens_hsa046680.55265297
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55207686
123* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55163062
124* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54973359
125* Choline metabolism in cancer_Homo sapiens_hsa052310.53381768
126Glucagon signaling pathway_Homo sapiens_hsa049220.53308389
127Tuberculosis_Homo sapiens_hsa051520.52671509
128Protein digestion and absorption_Homo sapiens_hsa049740.52496713

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »