PIK3R2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.24396841
2layer formation in cerebral cortex (GO:0021819)5.23549762
3locomotory exploration behavior (GO:0035641)5.12183035
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.75470319
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.74574345
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55707355
7positive regulation of synapse maturation (GO:0090129)4.55578460
8regulation of synapse structural plasticity (GO:0051823)4.15124854
9sodium ion export (GO:0071436)4.13455549
10cytoskeletal anchoring at plasma membrane (GO:0007016)4.05002996
11protein retention in ER lumen (GO:0006621)4.04444375
12vocalization behavior (GO:0071625)4.02767563
13glutamate secretion (GO:0014047)4.00990976
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.96035891
15synaptic vesicle exocytosis (GO:0016079)3.83604274
16exploration behavior (GO:0035640)3.83335075
17dendritic spine morphogenesis (GO:0060997)3.78262232
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74787728
19cell migration in hindbrain (GO:0021535)3.73775746
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.72325915
21regulation of mammary gland epithelial cell proliferation (GO:0033599)3.66906563
22cerebellar Purkinje cell layer development (GO:0021680)3.54413009
23cell communication by electrical coupling (GO:0010644)3.53919971
24proline biosynthetic process (GO:0006561)3.51527763
25regulation of synaptic vesicle exocytosis (GO:2000300)3.48853954
26regulation of glutamate receptor signaling pathway (GO:1900449)3.48255832
27COPI coating of Golgi vesicle (GO:0048205)3.42080666
28Golgi transport vesicle coating (GO:0048200)3.42080666
29regulation of neuronal synaptic plasticity (GO:0048168)3.41167750
30neuromuscular process controlling balance (GO:0050885)3.39549639
31activation of protein kinase A activity (GO:0034199)3.36688603
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33232057
33negative regulation of cell size (GO:0045792)3.32975078
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28146416
35cellular potassium ion homeostasis (GO:0030007)3.27360297
36semaphorin-plexin signaling pathway (GO:0071526)3.24584685
37protein localization to synapse (GO:0035418)3.22786373
38dendrite morphogenesis (GO:0048813)3.21896990
39glial cell proliferation (GO:0014009)3.21811665
40negative regulation of catenin import into nucleus (GO:0035414)3.11997219
41negative regulation of microtubule polymerization (GO:0031115)3.11137264
42basement membrane organization (GO:0071711)3.09454447
43convergent extension (GO:0060026)3.09161913
44neurotransmitter secretion (GO:0007269)3.07812831
45establishment of nucleus localization (GO:0040023)3.06212012
46Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.05050656
47proline transport (GO:0015824)3.05003500
48positive regulation of fibroblast migration (GO:0010763)3.03918751
49dendritic spine organization (GO:0097061)3.03344784
50retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01339164
51establishment of apical/basal cell polarity (GO:0035089)2.98198923
52plasma membrane repair (GO:0001778)2.97161308
53regulation of synaptic vesicle transport (GO:1902803)2.97112004
54innervation (GO:0060384)2.96023865
55protein heterotrimerization (GO:0070208)2.92969948
56negative regulation of organelle assembly (GO:1902116)2.92952895
57desmosome organization (GO:0002934)2.92887351
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.90605591
59peptidyl-lysine dimethylation (GO:0018027)2.89855733
60focal adhesion assembly (GO:0048041)2.89636281
61cell-substrate adherens junction assembly (GO:0007045)2.89636281
62regulation of ARF GTPase activity (GO:0032312)2.89161135
63regulation of dendritic spine morphogenesis (GO:0061001)2.87583798
64cochlea morphogenesis (GO:0090103)2.84595977
65regulation of establishment of planar polarity (GO:0090175)2.83075165
66positive regulation of dendrite morphogenesis (GO:0050775)2.82518868
67positive regulation of axon extension (GO:0045773)2.81186443
68regulation of synapse maturation (GO:0090128)2.79490828
69synaptic vesicle endocytosis (GO:0048488)2.77516245
70stress fiber assembly (GO:0043149)2.75797522
71positive regulation of dendritic spine morphogenesis (GO:0061003)2.74607433
72epithelial cell-cell adhesion (GO:0090136)2.73003662
73regulation of ARF protein signal transduction (GO:0032012)2.72318139
74proline metabolic process (GO:0006560)2.71378411
75regulation of NFAT protein import into nucleus (GO:0051532)2.69235205
76positive regulation of dendrite development (GO:1900006)2.66582507
77regulation of early endosome to late endosome transport (GO:2000641)2.66580198
78signal complex assembly (GO:0007172)2.66344434
79regulation of cholesterol biosynthetic process (GO:0045540)2.66069111
80regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.64263857
81axonal fasciculation (GO:0007413)2.62410527
82cellular sodium ion homeostasis (GO:0006883)2.61750995
83regulation of fatty acid beta-oxidation (GO:0031998)2.59511484
84cerebellar granule cell differentiation (GO:0021707)2.59369186
85adherens junction assembly (GO:0034333)2.58862689
86cell communication involved in cardiac conduction (GO:0086065)2.58609318
87cell-substrate junction assembly (GO:0007044)2.58509343
88axon extension (GO:0048675)2.57858035
89regulation of glucose import in response to insulin stimulus (GO:2001273)2.57760225
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57441264
91alanine transport (GO:0032328)2.57352960
92protein targeting to plasma membrane (GO:0072661)2.56759653
93pyrimidine nucleobase catabolic process (GO:0006208)2.56695603
94maternal placenta development (GO:0001893)2.56077515
95establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55089479
96mitochondrion transport along microtubule (GO:0047497)2.55089479
97regulation of synaptic plasticity (GO:0048167)2.54895827
98establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.54887001
99establishment of monopolar cell polarity (GO:0061162)2.54123790
100establishment or maintenance of monopolar cell polarity (GO:0061339)2.54123790
101prepulse inhibition (GO:0060134)2.53419637
102apoptotic process involved in morphogenesis (GO:0060561)2.50841389
103dopamine receptor signaling pathway (GO:0007212)2.50813026
104regulation of clathrin-mediated endocytosis (GO:2000369)2.49228230
105polarized epithelial cell differentiation (GO:0030859)2.46722675
106ephrin receptor signaling pathway (GO:0048013)2.45162504
107clathrin coat assembly (GO:0048268)2.44483518
108insulin-like growth factor receptor signaling pathway (GO:0048009)2.44052527
109regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.43775728
110central nervous system projection neuron axonogenesis (GO:0021952)2.43716646
111neurotransmitter-gated ion channel clustering (GO:0072578)2.43663747
112axon cargo transport (GO:0008088)2.43571747
113skin morphogenesis (GO:0043589)2.43362871
114activation of Rac GTPase activity (GO:0032863)2.41590626
115peptidyl-arginine omega-N-methylation (GO:0035247)2.41409565
116cell-cell junction maintenance (GO:0045217)2.41258024
117auditory behavior (GO:0031223)2.41166035
118long-term memory (GO:0007616)2.40654550
119neuron recognition (GO:0008038)2.39881004
120skeletal muscle organ development (GO:0060538)2.39851266
121negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39786896
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.38989097
123ionotropic glutamate receptor signaling pathway (GO:0035235)2.38981009
124positive regulation of nitric-oxide synthase activity (GO:0051000)2.38358275
125regulation of axon extension involved in axon guidance (GO:0048841)2.38242406
126establishment or maintenance of bipolar cell polarity (GO:0061245)2.38225931
127establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38225931
128hemidesmosome assembly (GO:0031581)2.37976055
129neuron projection extension (GO:1990138)2.37730564
130heparan sulfate proteoglycan metabolic process (GO:0030201)2.36974470
131cell junction maintenance (GO:0034331)2.36754866
132positive regulation of dendritic spine development (GO:0060999)2.36740538
133organelle transport along microtubule (GO:0072384)2.36434999
134regulation of extracellular matrix disassembly (GO:0010715)2.36420268
135negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.36322361
136regulation of autophagic vacuole assembly (GO:2000785)2.35528452
137synaptic transmission, glutamatergic (GO:0035249)2.35128928
138regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34292638
139glucose 6-phosphate metabolic process (GO:0051156)2.33846862
140protein localization to endosome (GO:0036010)2.33704187
141positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.32891244
142negative regulation of fatty acid transport (GO:2000192)2.30834928
143lung epithelium development (GO:0060428)2.30696897
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.29991969
145regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29475881
146positive regulation of membrane potential (GO:0045838)2.28574417
147eye morphogenesis (GO:0048592)2.28360727
148branching involved in mammary gland duct morphogenesis (GO:0060444)2.28291740
149non-canonical Wnt signaling pathway (GO:0035567)2.27718203
150cellular response to prostaglandin stimulus (GO:0071379)2.27304927
151atrioventricular valve morphogenesis (GO:0003181)2.26976788
152embryonic eye morphogenesis (GO:0048048)2.26121662
153regulation of cholesterol homeostasis (GO:2000188)2.25899732
154protein-DNA complex disassembly (GO:0032986)2.23403901
155nucleosome disassembly (GO:0006337)2.23403901
156neural tube development (GO:0021915)2.21602582
157camera-type eye morphogenesis (GO:0048593)2.20239688
158adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.19320158
159diaphragm development (GO:0060539)2.19217944
160regulation of translational fidelity (GO:0006450)2.18914406
161tooth mineralization (GO:0034505)2.17852993
162response to parathyroid hormone (GO:0071107)2.15831804
163activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.15738790
164ear development (GO:0043583)2.14427947
165paraxial mesoderm development (GO:0048339)2.13240363
166negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.12553193
167vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.11087552
168outflow tract septum morphogenesis (GO:0003148)2.10455553
169embryonic retina morphogenesis in camera-type eye (GO:0060059)2.09875585
170modulation by virus of host morphology or physiology (GO:0019048)2.09470857
171body morphogenesis (GO:0010171)2.09229496
172intracellular estrogen receptor signaling pathway (GO:0030520)2.09134373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.44504989
2ZFP281_18757296_ChIP-ChIP_E14_Mouse2.87366304
3EZH2_22144423_ChIP-Seq_EOC_Human2.73314066
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.59906675
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.42489227
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40450945
7LXR_22292898_ChIP-Seq_THP-1_Human2.37562322
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.34778337
9KDM2B_26808549_Chip-Seq_K562_Human2.33831506
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30621582
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.27491770
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.24264387
13DROSHA_22980978_ChIP-Seq_HELA_Human2.22199919
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.17281688
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.13048208
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11331511
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10194396
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10194396
19* KDM2B_26808549_Chip-Seq_DND41_Human2.07079907
20* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human2.03840653
21ZNF263_19887448_ChIP-Seq_K562_Human1.99811056
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99285486
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.88702714
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87467998
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.86645757
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.79185434
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77556639
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74997547
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.74713195
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73643103
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73160461
32DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73093641
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72527303
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70117902
35TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69854029
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.69352353
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67806750
38* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64414916
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64121542
40* KDM2B_26808549_Chip-Seq_JURKAT_Human1.63839253
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62560109
42MYC_22102868_ChIP-Seq_BL_Human1.59953431
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57570781
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56925328
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56600973
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.55705522
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.55641261
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55072680
49SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54450839
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.53872863
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53552895
52* REST_21632747_ChIP-Seq_MESCs_Mouse1.52768507
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.52512410
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51794664
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.51580113
56ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51129308
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51066432
58CREB1_26743006_Chip-Seq_LNCaP_Human1.50483306
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47813527
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47340620
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47218110
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.42555112
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40909243
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.39400310
65* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39342827
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39219877
67CLOCK_20551151_ChIP-Seq_293T_Human1.39012377
68ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38089986
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.37448995
70EED_16625203_ChIP-ChIP_MESCs_Mouse1.37430348
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36968674
72TCF7_22412390_ChIP-Seq_EML_Mouse1.34548455
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33965136
74* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.33737962
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33538327
76* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33395620
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32662799
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.32150520
79CTCF_27219007_Chip-Seq_Bcells_Human1.32150100
80SMC4_20622854_ChIP-Seq_HELA_Human1.32035591
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.30563554
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27735538
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.26820862
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25794632
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25591001
86* P68_20966046_ChIP-Seq_HELA_Human1.25038986
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24716305
88TET1_21490601_ChIP-Seq_MESCs_Mouse1.24289157
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23162381
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22276465
91* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21560315
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21321231
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18390199
94* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17369687
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17168913
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15846297
97ATF3_27146783_Chip-Seq_COLON_Human1.15134695
98TP53_22127205_ChIP-Seq_IMR90_Human1.15025258
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13406441
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13304532
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12089675
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.11413816
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10844457
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10503569
105EGR1_19374776_ChIP-ChIP_THP-1_Human1.10384178
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09435293
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07112824
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.06954698
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05711691
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.05440509
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.04644086
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02202941
113MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02078230
114* TP63_22573176_ChIP-Seq_HFKS_Human0.99916551
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99410535
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99407777
117VDR_21846776_ChIP-Seq_THP-1_Human0.97364658
118TET1_21451524_ChIP-Seq_MESCs_Mouse0.96788758
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96477057
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.95784186
121CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94614431
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92476363
123* OCT4_19829295_ChIP-Seq_ESCs_Human0.92228490

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.80801165
2MP0003705_abnormal_hypodermis_morpholog3.81065588
3MP0003283_abnormal_digestive_organ3.30189151
4MP0004858_abnormal_nervous_system3.11186577
5MP0010234_abnormal_vibrissa_follicle2.99554280
6MP0003635_abnormal_synaptic_transmissio2.78389667
7MP0005257_abnormal_intraocular_pressure2.68807802
8MP0008438_abnormal_cutaneous_collagen2.40958851
9MP0004270_analgesia2.38561984
10MP0000566_synostosis2.33674519
11MP0009780_abnormal_chondrocyte_physiolo2.31328950
12MP0005623_abnormal_meninges_morphology2.25582982
13MP0002234_abnormal_pharynx_morphology2.18388849
14MP0002063_abnormal_learning/memory/cond2.16745437
15MP0005409_darkened_coat_color2.01928984
16MP0004233_abnormal_muscle_weight1.90704456
17MP0003329_amyloid_beta_deposits1.90392332
18MP0002909_abnormal_adrenal_gland1.86220366
19MP0000537_abnormal_urethra_morphology1.77821707
20MP0005275_abnormal_skin_tensile1.76734523
21MP0004811_abnormal_neuron_physiology1.71758708
22MP0002653_abnormal_ependyma_morphology1.66767578
23MP0000751_myopathy1.65166825
24MP0000678_abnormal_parathyroid_gland1.64044778
25MP0008961_abnormal_basal_metabolism1.63146617
26MP0000534_abnormal_ureter_morphology1.62971617
27MP0010030_abnormal_orbit_morphology1.60082688
28MP0000569_abnormal_digit_pigmentation1.57489611
29MP0000579_abnormal_nail_morphology1.56394638
30MP0009745_abnormal_behavioral_response1.54066438
31MP0010352_gastrointestinal_tract_polyps1.53920289
32MP0009384_cardiac_valve_regurgitation1.53391423
33MP0000462_abnormal_digestive_system1.51931046
34MP0005076_abnormal_cell_differentiation1.50321554
35MP0000778_abnormal_nervous_system1.49433960
36MP0002064_seizures1.46377260
37MP0001849_ear_inflammation1.43014005
38MP0008569_lethality_at_weaning1.41259789
39MP0002184_abnormal_innervation1.40597798
40MP0000955_abnormal_spinal_cord1.40238830
41MP0005058_abnormal_lysosome_morphology1.39795806
42MP0001348_abnormal_lacrimal_gland1.39185238
43MP0002089_abnormal_postnatal_growth/wei1.36042263
44MP0003122_maternal_imprinting1.29886181
45MP0002060_abnormal_skin_morphology1.29195341
46MP0003879_abnormal_hair_cell1.28072073
47MP0002572_abnormal_emotion/affect_behav1.27632895
48MP0000762_abnormal_tongue_morphology1.27077705
49MP0005423_abnormal_somatic_nervous1.26196459
50MP0002822_catalepsy1.24626028
51MP0005499_abnormal_olfactory_system1.23866364
52MP0005394_taste/olfaction_phenotype1.23866364
53MP0002734_abnormal_mechanical_nocicepti1.23265595
54MP0003172_abnormal_lysosome_physiology1.22813607
55MP0003115_abnormal_respiratory_system1.21628088
56MP0009053_abnormal_anal_canal1.21422580
57MP0003942_abnormal_urinary_system1.19790108
58MP0004885_abnormal_endolymph1.19403004
59MP0004185_abnormal_adipocyte_glucose1.18366855
60MP0003119_abnormal_digestive_system1.18096295
61MP0009046_muscle_twitch1.16997782
62MP0009672_abnormal_birth_weight1.16200447
63MP0001968_abnormal_touch/_nociception1.10555445
64MP0003385_abnormal_body_wall1.10184624
65MP0003634_abnormal_glial_cell1.07023358
66MP0000733_abnormal_muscle_development1.05353265
67MP0002152_abnormal_brain_morphology1.05295988
68MP0005503_abnormal_tendon_morphology1.05255613
69MP0002882_abnormal_neuron_morphology1.03717415
70MP0000013_abnormal_adipose_tissue1.03145879
71MP0005501_abnormal_skin_physiology1.02857698
72MP0005187_abnormal_penis_morphology1.02226305
73MP0002796_impaired_skin_barrier1.01440924
74MP0009840_abnormal_foam_cell1.00598795
75MP0002896_abnormal_bone_mineralization1.00040120
76MP0002733_abnormal_thermal_nociception0.99674814
77MP0009250_abnormal_appendicular_skeleto0.99623314
78MP0003861_abnormal_nervous_system0.99467025
79MP0003566_abnormal_cell_adhesion0.97898321
80MP0002557_abnormal_social/conspecific_i0.97066160
81MP0001958_emphysema0.94528521
82MP0002098_abnormal_vibrissa_morphology0.94453310
83MP0008260_abnormal_autophagy0.94165968
84MP0000003_abnormal_adipose_tissue0.93298331
85MP0005451_abnormal_body_composition0.91862422
86MP0002877_abnormal_melanocyte_morpholog0.90851319
87MP0003075_altered_response_to0.90283098
88MP0004264_abnormal_extraembryonic_tissu0.90168465
89MP0001299_abnormal_eye_distance/0.90114435
90MP0002697_abnormal_eye_size0.89882890
91MP0003279_aneurysm0.89691616
92MP0000428_abnormal_craniofacial_morphol0.89139944
93MP0008789_abnormal_olfactory_epithelium0.88037502
94MP0009379_abnormal_foot_pigmentation0.86737467
95MP0005248_abnormal_Harderian_gland0.86649487
96MP0001486_abnormal_startle_reflex0.86621473
97MP0003045_fibrosis0.86038760
98MP0001440_abnormal_grooming_behavior0.84024009
99MP0003453_abnormal_keratinocyte_physiol0.83870248
100MP0002272_abnormal_nervous_system0.82039233
101MP0002090_abnormal_vision0.81984522
102MP0002114_abnormal_axial_skeleton0.81575754
103MP0002066_abnormal_motor_capabilities/c0.81160036
104MP0003123_paternal_imprinting0.80732015
105MP0001970_abnormal_pain_threshold0.79777202
106MP0004272_abnormal_basement_membrane0.79215674
107MP0002249_abnormal_larynx_morphology0.79140683
108MP0003091_abnormal_cell_migration0.78863475
109MP0003880_abnormal_central_pattern0.77511264
110MP0000759_abnormal_skeletal_muscle0.77124950
111MP0004087_abnormal_muscle_fiber0.76457251
112MP0000747_muscle_weakness0.75871780
113MP0000432_abnormal_head_morphology0.75742747
114MP0005375_adipose_tissue_phenotype0.75527875
115MP0002736_abnormal_nociception_after0.75132066
116MP0003755_abnormal_palate_morphology0.74786180
117MP0000049_abnormal_middle_ear0.74632951
118MP0001340_abnormal_eyelid_morphology0.74610271
119MP0008770_decreased_survivor_rate0.74558519
120MP0001177_atelectasis0.74000180
121MP0002269_muscular_atrophy0.73809632
122MP0000681_abnormal_thyroid_gland0.73269639
123MP0006054_spinal_hemorrhage0.72930138
124MP0001346_abnormal_lacrimal_gland0.72362238
125MP0002932_abnormal_joint_morphology0.72066373
126MP0002085_abnormal_embryonic_tissue0.71696818
127MP0002092_abnormal_eye_morphology0.70496738
128MP0004130_abnormal_muscle_cell0.70188988
129MP0002116_abnormal_craniofacial_bone0.69878556
130MP0002233_abnormal_nose_morphology0.69659191
131MP0000467_abnormal_esophagus_morphology0.67330408
132MP0003935_abnormal_craniofacial_develop0.67174652
133MP0002081_perinatal_lethality0.66764694
134MP0005508_abnormal_skeleton_morphology0.66590082
135MP0001730_embryonic_growth_arrest0.66417872
136MP0010771_integument_phenotype0.66400232
137MP0002108_abnormal_muscle_morphology0.66213550
138MP0001502_abnormal_circadian_rhythm0.64414533
139MP0000767_abnormal_smooth_muscle0.64403190
140MP0003937_abnormal_limbs/digits/tail_de0.63523439

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)3.77288547
2Protrusio acetabuli (HP:0003179)3.71430934
3Myokymia (HP:0002411)3.64947942
4Shallow orbits (HP:0000586)3.60162091
5Hyperacusis (HP:0010780)3.36118492
6Insomnia (HP:0100785)3.35411638
7Ulnar bowing (HP:0003031)3.10682898
8Visual hallucinations (HP:0002367)2.94618805
9Ankle contracture (HP:0006466)2.92447720
10Cerebral aneurysm (HP:0004944)2.88977660
11Bladder diverticulum (HP:0000015)2.85086392
12Bowel diverticulosis (HP:0005222)2.84289760
13Asymmetry of the thorax (HP:0001555)2.81478852
14Distal upper limb amyotrophy (HP:0007149)2.80374859
15Upper limb amyotrophy (HP:0009129)2.80374859
16Pointed chin (HP:0000307)2.78603836
17Genu recurvatum (HP:0002816)2.70467977
18Elfin facies (HP:0004428)2.66304324
19Premature rupture of membranes (HP:0001788)2.65645789
20Vertebral compression fractures (HP:0002953)2.64289040
21Renal duplication (HP:0000075)2.63588188
22Renovascular hypertension (HP:0100817)2.62759995
23Achilles tendon contracture (HP:0001771)2.53549508
24Hand muscle atrophy (HP:0009130)2.52524699
25Ankyloglossia (HP:0010296)2.51864918
26Annular pancreas (HP:0001734)2.46807673
27Abnormality of dentin (HP:0010299)2.43879796
28Neoplasm of the heart (HP:0100544)2.40533582
29Broad metatarsal (HP:0001783)2.40234226
30Biconcave vertebral bodies (HP:0004586)2.38074728
31Overriding aorta (HP:0002623)2.35925708
32Hypercortisolism (HP:0001578)2.34869484
33Cervical subluxation (HP:0003308)2.32567642
34Focal seizures (HP:0007359)2.31980941
35Disproportionate tall stature (HP:0001519)2.31232326
36Ankle clonus (HP:0011448)2.29720326
37Abnormality of the Achilles tendon (HP:0005109)2.28745583
38Abnormality of the astrocytes (HP:0100707)2.28446818
39Astrocytoma (HP:0009592)2.28446818
40Dilatation of the ascending aorta (HP:0005111)2.24686723
41Flat cornea (HP:0007720)2.24239991
42Turricephaly (HP:0000262)2.24089084
43Torticollis (HP:0000473)2.23890751
44Atrophic scars (HP:0001075)2.21162079
45Lymphangioma (HP:0100764)2.20825672
46Supranuclear gaze palsy (HP:0000605)2.20002933
47Neonatal short-limb short stature (HP:0008921)2.18361429
48Enlarged penis (HP:0000040)2.17815702
49Hyperparathyroidism (HP:0000843)2.16392830
50Hypoventilation (HP:0002791)2.15835004
51Mildly elevated creatine phosphokinase (HP:0008180)2.15079001
52Action tremor (HP:0002345)2.14183829
53Broad face (HP:0000283)2.13821627
54Depression (HP:0000716)2.12044272
55Blue sclerae (HP:0000592)2.10665873
56Increased variability in muscle fiber diameter (HP:0003557)2.09413230
57Bronchomalacia (HP:0002780)2.09372690
58Mitral valve prolapse (HP:0001634)2.08282989
59Deep venous thrombosis (HP:0002625)2.08268749
60Stridor (HP:0010307)2.07874647
61Deviation of the hallux (HP:0010051)2.05337959
62Hallux valgus (HP:0001822)2.04259588
63Thin ribs (HP:0000883)2.04170665
64Back pain (HP:0003418)2.03818267
65Fragile skin (HP:0001030)2.03692836
66Short 4th metacarpal (HP:0010044)2.03004633
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03004633
68Reticulocytosis (HP:0001923)2.02991026
69Type 1 muscle fiber predominance (HP:0003803)2.01258277
70Advanced eruption of teeth (HP:0006288)2.00373494
71Obstructive sleep apnea (HP:0002870)1.99844322
72Hyperextensible skin (HP:0000974)1.99399034
73Abnormality of oral frenula (HP:0000190)1.97803273
74Patellar dislocation (HP:0002999)1.97063148
75Premature skin wrinkling (HP:0100678)1.97031263
76Fibroma (HP:0010614)1.96988942
77Wormian bones (HP:0002645)1.96718478
78Focal dystonia (HP:0004373)1.96598470
79Aplasia involving bones of the extremities (HP:0009825)1.95761377
80Aplasia involving bones of the upper limbs (HP:0009823)1.95761377
81Aplasia of the phalanges of the hand (HP:0009802)1.95761377
82Thin bony cortex (HP:0002753)1.93882552
83Amyotrophic lateral sclerosis (HP:0007354)1.93114341
84Buphthalmos (HP:0000557)1.92758935
85Lower limb amyotrophy (HP:0007210)1.92439810
86Poor eye contact (HP:0000817)1.92275388
87Abnormal social behavior (HP:0012433)1.90958565
88Impaired social interactions (HP:0000735)1.90958565
89Posterior subcapsular cataract (HP:0007787)1.88901813
90Overgrowth (HP:0001548)1.87493239
91Broad distal phalanx of finger (HP:0009836)1.87443450
92Vascular tortuosity (HP:0004948)1.86149460
93Hyperthyroidism (HP:0000836)1.85303141
94Fibrous tissue neoplasm (HP:0012316)1.84022217
95Craniofacial dystonia (HP:0012179)1.82909435
96Cerebral inclusion bodies (HP:0100314)1.82663143
97Macroorchidism (HP:0000053)1.81756128
98Bowed forearm bones (HP:0003956)1.80760199
99Bowing of the arm (HP:0006488)1.80760199
100Precocious puberty (HP:0000826)1.80519946
101Arterial tortuosity (HP:0005116)1.79426222
102Long toe (HP:0010511)1.79317198
103Hypercalcemia (HP:0003072)1.79237053
104Apathy (HP:0000741)1.78501844
105Atelectasis (HP:0100750)1.78351723
106Flat acetabular roof (HP:0003180)1.78028028
107Papilledema (HP:0001085)1.77254851
108* Mitral regurgitation (HP:0001653)1.76911206
109J-shaped sella turcica (HP:0002680)1.76587291
110Difficulty climbing stairs (HP:0003551)1.76535094
111Increased connective tissue (HP:0009025)1.76123334
112Germ cell neoplasia (HP:0100728)1.75474420
113Insidious onset (HP:0003587)1.75328151
114Termporal pattern (HP:0011008)1.75328151
115Elbow flexion contracture (HP:0002987)1.75098587
116Hemiplegia (HP:0002301)1.73996446
117Abnormality of the distal phalanx of the thumb (HP:0009617)1.73067305
118Coronal craniosynostosis (HP:0004440)1.72941824
119Abnormality of the 4th metacarpal (HP:0010012)1.71693964
120Congenital glaucoma (HP:0001087)1.71382686
121Abnormality of skeletal muscle fiber size (HP:0012084)1.70658398
122Impaired vibration sensation in the lower limbs (HP:0002166)1.69704398
123Amblyopia (HP:0000646)1.69360965
124Ventricular fibrillation (HP:0001663)1.68874325
125Aneurysm (HP:0002617)1.67976489
126Adenoma sebaceum (HP:0009720)1.67812995
127Angiofibromas (HP:0010615)1.67812995
128Diminished motivation (HP:0000745)1.67452705
129Truncus arteriosus (HP:0001660)1.67239809
130Striae distensae (HP:0001065)1.67187747
131Distal lower limb amyotrophy (HP:0008944)1.67065448
132Joint laxity (HP:0001388)1.66164090
133Abnormality of the phalanges of the hallux (HP:0010057)1.65755875
134Spinal cord compression (HP:0002176)1.65306438
135Focal motor seizures (HP:0011153)1.65270674
136Mutism (HP:0002300)1.64820585
137Natal tooth (HP:0000695)1.64246517
138Pterygium (HP:0001059)1.63291102
139Urinary urgency (HP:0000012)1.63169996
140Megalocornea (HP:0000485)1.61536322
141Soft skin (HP:0000977)1.60595679
142Arnold-Chiari malformation (HP:0002308)1.60392748
143Rapidly progressive (HP:0003678)1.60382043
144Spinal rigidity (HP:0003306)1.59998874
145Dysmetric saccades (HP:0000641)1.59866619
146Neurofibrillary tangles (HP:0002185)1.59753357
147Wrist flexion contracture (HP:0001239)1.58772174
148Protruding ear (HP:0000411)1.56956911
149Breech presentation (HP:0001623)1.56660277
150Increased nuchal translucency (HP:0010880)1.55409926
151Distal lower limb muscle weakness (HP:0009053)1.54602225
152Short nail (HP:0001799)1.53962408
153Partial duplication of the phalanx of hand (HP:0009999)1.53413144
154Partial duplication of thumb phalanx (HP:0009944)1.53246826
155Abnormal ossification of hand bones (HP:0005921)1.52326219

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.04663230
2SMG13.43075603
3MAP3K93.26448700
4PKN22.95462893
5MARK12.76873030
6PRKD32.54716918
7RIPK12.48674000
8KSR22.33372149
9PAK62.26715694
10EPHA22.21633722
11EEF2K2.20607259
12LATS22.18998318
13CAMKK12.14536334
14EPHA42.12086360
15DDR22.06997317
16DAPK22.01566625
17ICK2.01068211
18NTRK32.01063841
19MINK11.98629658
20MAP3K101.94178722
21PDGFRA1.91052646
22IRAK31.81987067
23NTRK11.79800996
24TAOK11.78764971
25CDK121.76730299
26FGFR41.71696509
27TYRO31.69941931
28NEK11.65252532
29KSR11.58442717
30EPHB21.58354538
31SCYL21.51440528
32LMTK21.48259765
33SIK21.46966371
34BMX1.26520102
35DAPK11.20848201
36TTN1.19505183
37MAP3K41.19262202
38ALK1.17208854
39NME21.16544771
40NTRK21.15860394
41PTK61.14725743
42RET1.14699374
43PTK21.14378147
44SIK11.08552154
45PHKG11.06130386
46PHKG21.06130386
47MAP3K21.06005257
48CDK51.05183821
49STK381.03675100
50ERN11.01802811
51MAP2K20.97040763
52PAK30.96217598
53TESK10.95542942
54ARAF0.94318542
55CDK150.92047681
56BRAF0.90421952
57MAPKAPK30.90419901
58FER0.90229757
59CDK180.87781293
60PDPK10.87668059
61RPS6KB20.84449159
62CDK140.84329868
63UHMK10.83704213
64MET0.82766345
65CDK11A0.82069751
66MAP2K10.80468651
67MARK20.80313895
68PAK40.78976154
69ILK0.78282566
70CAMK1D0.75905573
71HIPK20.74053641
72DAPK30.73321958
73MTOR0.72218989
74STK110.71276205
75FGFR10.70521304
76PAK20.70472334
77MST1R0.69089721
78RPS6KC10.68885491
79RPS6KL10.68885491
80LIMK10.68136610
81PTK2B0.65903781
82CDK70.65757271
83MAP2K40.64959579
84PRKCH0.64552201
85DYRK1B0.63374395
86MAPK110.61904349
87CDC42BPA0.61243935
88LRRK20.60282092
89PRKCG0.58465179
90RPS6KA20.58200730
91DMPK0.57856397
92PIM20.56322036
93MAP3K70.55554761
94CAMK2G0.54400235
95RAF10.53787402
96ERBB20.53406584
97TAOK30.53399715
98TESK20.53263651
99CAMK2B0.52974328
100ROCK10.51694501
101TAOK20.51390176
102IRAK20.50697167
103WNK10.49272915
104PRKCZ0.48723019
105RPS6KA60.48287105
106PDGFRB0.47898913
107FGFR20.47797549
108SGK30.47172874
109PRKCI0.46905973
110BRSK10.46888299
111MAP3K10.45359398
112PRPF4B0.44867084
113ERBB30.44408776
114PRKD20.44124100
115MAP3K110.43769671
116CAMK10.43358976
117CAMK1G0.42874714
118PRKG20.41428000
119MAP3K80.40485623
120CDK90.40237266
121CAMKK20.37253635
122AURKA0.36867776
123CAMK40.36544784
124CDK80.36429235
125MAPK100.35945546
126SRC0.35930061
127ROCK20.35800036
128MAPK80.33903320
129CDK190.33633587
130PRKD10.33140791
131PLK20.32058838
132MAPK90.31914754
133AKT20.31903685
134RPS6KA30.31809887
135FYN0.31260520

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.46451362
2Synaptic vesicle cycle_Homo sapiens_hsa047212.21304935
3Long-term potentiation_Homo sapiens_hsa047201.97242035
4Olfactory transduction_Homo sapiens_hsa047401.96760723
5Circadian entrainment_Homo sapiens_hsa047131.94282435
6Vitamin B6 metabolism_Homo sapiens_hsa007501.72613342
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69499853
8Aldosterone synthesis and secretion_Homo sapiens_hsa049251.69452058
9* Glioma_Homo sapiens_hsa052141.68188260
10Gastric acid secretion_Homo sapiens_hsa049711.66791071
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.66630986
12Salivary secretion_Homo sapiens_hsa049701.66138559
13Gap junction_Homo sapiens_hsa045401.65308754
14* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64494159
15Sulfur relay system_Homo sapiens_hsa041221.63706055
16Amphetamine addiction_Homo sapiens_hsa050311.62984473
17Dopaminergic synapse_Homo sapiens_hsa047281.62931655
18Glutamatergic synapse_Homo sapiens_hsa047241.59577432
19GABAergic synapse_Homo sapiens_hsa047271.58743933
20Cyanoamino acid metabolism_Homo sapiens_hsa004601.58513526
21GnRH signaling pathway_Homo sapiens_hsa049121.53811924
22Insulin secretion_Homo sapiens_hsa049111.52957708
23Nicotine addiction_Homo sapiens_hsa050331.48613054
24* Estrogen signaling pathway_Homo sapiens_hsa049151.47348102
25Axon guidance_Homo sapiens_hsa043601.44182380
26* Cholinergic synapse_Homo sapiens_hsa047251.44036662
27* Oxytocin signaling pathway_Homo sapiens_hsa049211.41858515
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38580598
29Bladder cancer_Homo sapiens_hsa052191.30586797
30Morphine addiction_Homo sapiens_hsa050321.30056639
31Melanogenesis_Homo sapiens_hsa049161.29582040
32* Endometrial cancer_Homo sapiens_hsa052131.28086609
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27405491
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.27067038
35Pentose phosphate pathway_Homo sapiens_hsa000301.24011661
36Renin secretion_Homo sapiens_hsa049241.23353290
37* mTOR signaling pathway_Homo sapiens_hsa041501.21824289
38Cocaine addiction_Homo sapiens_hsa050301.21032990
39Nitrogen metabolism_Homo sapiens_hsa009101.20409818
40Hippo signaling pathway_Homo sapiens_hsa043901.20175725
41* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19470373
42Vibrio cholerae infection_Homo sapiens_hsa051101.17014171
43* Central carbon metabolism in cancer_Homo sapiens_hsa052301.16366692
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16244729
45Hedgehog signaling pathway_Homo sapiens_hsa043401.14162268
46Long-term depression_Homo sapiens_hsa047301.13545896
47Basal cell carcinoma_Homo sapiens_hsa052171.11428367
48Fructose and mannose metabolism_Homo sapiens_hsa000511.11130780
49* ErbB signaling pathway_Homo sapiens_hsa040121.10953524
50* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10454531
51Oocyte meiosis_Homo sapiens_hsa041141.09487642
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09181993
53Dilated cardiomyopathy_Homo sapiens_hsa054141.07019084
54Lysine degradation_Homo sapiens_hsa003101.06810174
55* VEGF signaling pathway_Homo sapiens_hsa043701.06112401
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05105441
57* Chronic myeloid leukemia_Homo sapiens_hsa052201.04212068
58* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03693214
59* Neurotrophin signaling pathway_Homo sapiens_hsa047221.03149787
60* Proteoglycans in cancer_Homo sapiens_hsa052051.02302287
61Galactose metabolism_Homo sapiens_hsa000521.00897584
62* Focal adhesion_Homo sapiens_hsa045101.00137823
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99855760
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99064294
65Other glycan degradation_Homo sapiens_hsa005110.97975369
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96666191
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96024113
68* Type II diabetes mellitus_Homo sapiens_hsa049300.95657879
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95175849
70* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95011609
71Arginine biosynthesis_Homo sapiens_hsa002200.94639713
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94178150
73* Non-small cell lung cancer_Homo sapiens_hsa052230.93291367
74* Phospholipase D signaling pathway_Homo sapiens_hsa040720.92624685
75Calcium signaling pathway_Homo sapiens_hsa040200.89987393
76Bile secretion_Homo sapiens_hsa049760.89025827
77* Colorectal cancer_Homo sapiens_hsa052100.88935662
78Endocytosis_Homo sapiens_hsa041440.86501923
79* Insulin signaling pathway_Homo sapiens_hsa049100.85930512
80* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85719732
81Tight junction_Homo sapiens_hsa045300.83461321
82Arginine and proline metabolism_Homo sapiens_hsa003300.83236971
83Thyroid hormone synthesis_Homo sapiens_hsa049180.83006910
84* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82830842
85Inositol phosphate metabolism_Homo sapiens_hsa005620.82526293
86Glucagon signaling pathway_Homo sapiens_hsa049220.81947404
87* cAMP signaling pathway_Homo sapiens_hsa040240.81039283
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80377357
89Dorso-ventral axis formation_Homo sapiens_hsa043200.80104548
90Wnt signaling pathway_Homo sapiens_hsa043100.78698520
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76517148
92N-Glycan biosynthesis_Homo sapiens_hsa005100.76460344
93Carbon metabolism_Homo sapiens_hsa012000.74975330
94* Rap1 signaling pathway_Homo sapiens_hsa040150.74959302
95Adherens junction_Homo sapiens_hsa045200.72452978
96Thyroid cancer_Homo sapiens_hsa052160.72213479
97* Melanoma_Homo sapiens_hsa052180.71205058
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71005213
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.70414507
100Protein digestion and absorption_Homo sapiens_hsa049740.69106309
101* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69057628
102ECM-receptor interaction_Homo sapiens_hsa045120.68645927
103Phenylalanine metabolism_Homo sapiens_hsa003600.68209192
104* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67626854
105MAPK signaling pathway_Homo sapiens_hsa040100.66736663
106* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66310301
107* AMPK signaling pathway_Homo sapiens_hsa041520.66053262
108* Renal cell carcinoma_Homo sapiens_hsa052110.65869992
109* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65289981
110Notch signaling pathway_Homo sapiens_hsa043300.65273216
111* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62989680
112* Choline metabolism in cancer_Homo sapiens_hsa052310.62787388
113Taste transduction_Homo sapiens_hsa047420.61610981
114* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61511261
115Fatty acid biosynthesis_Homo sapiens_hsa000610.61032247
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60882710
117* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60211621
118* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58117651
119* Prostate cancer_Homo sapiens_hsa052150.57989879
120* Acute myeloid leukemia_Homo sapiens_hsa052210.57980396
121Prion diseases_Homo sapiens_hsa050200.56743233
122Pancreatic secretion_Homo sapiens_hsa049720.56496936
123* Small cell lung cancer_Homo sapiens_hsa052220.56197687
124Biosynthesis of amino acids_Homo sapiens_hsa012300.55232714
125* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54974822
126* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53669134
127Alcoholism_Homo sapiens_hsa050340.53616557
128* Pancreatic cancer_Homo sapiens_hsa052120.53401487
129* MicroRNAs in cancer_Homo sapiens_hsa052060.52900807
130* Amoebiasis_Homo sapiens_hsa051460.49917755

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