PIK3R3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.97661806
2response to pheromone (GO:0019236)4.55644761
3nucleobase catabolic process (GO:0046113)4.35046805
4neuron cell-cell adhesion (GO:0007158)4.31299244
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03234575
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.93320733
7dendrite morphogenesis (GO:0048813)3.92574536
8layer formation in cerebral cortex (GO:0021819)3.88287980
9axonal fasciculation (GO:0007413)3.88009979
10cerebellar granule cell differentiation (GO:0021707)3.80762952
11synaptic vesicle maturation (GO:0016188)3.73459860
12dendritic spine morphogenesis (GO:0060997)3.65288164
13exploration behavior (GO:0035640)3.63692905
14neuron recognition (GO:0008038)3.58277747
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55220516
16synaptic vesicle exocytosis (GO:0016079)3.54993437
17regulation of synaptic vesicle exocytosis (GO:2000300)3.54788824
18vocalization behavior (GO:0071625)3.45439262
19L-amino acid import (GO:0043092)3.42278824
20transmission of nerve impulse (GO:0019226)3.26864944
21protein localization to synapse (GO:0035418)3.23166497
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20953121
23calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.19558403
24establishment of nucleus localization (GO:0040023)3.18764270
25amino acid import (GO:0043090)3.18269433
26retinal ganglion cell axon guidance (GO:0031290)3.17514887
27glutamate secretion (GO:0014047)3.13583166
28cell migration in hindbrain (GO:0021535)3.13066909
29neuronal ion channel clustering (GO:0045161)3.12320307
30cerebellar Purkinje cell differentiation (GO:0021702)3.12303695
31cellular potassium ion homeostasis (GO:0030007)3.09643714
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09091505
33negative regulation of axon extension (GO:0030517)3.08015901
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07218242
35central nervous system projection neuron axonogenesis (GO:0021952)3.01418839
36establishment of mitochondrion localization (GO:0051654)3.01150025
37auditory behavior (GO:0031223)2.99854612
38mating behavior (GO:0007617)2.93618239
39innervation (GO:0060384)2.92897393
40glutamate receptor signaling pathway (GO:0007215)2.89000526
41ionotropic glutamate receptor signaling pathway (GO:0035235)2.88245430
42regulation of synaptic vesicle transport (GO:1902803)2.86387754
43negative regulation of axon extension involved in axon guidance (GO:0048843)2.84721834
44positive regulation of synapse maturation (GO:0090129)2.83325448
45sympathetic nervous system development (GO:0048485)2.83186208
46neurotransmitter secretion (GO:0007269)2.82181074
47limb bud formation (GO:0060174)2.81775357
48synaptic vesicle docking involved in exocytosis (GO:0016081)2.81759419
49gamma-aminobutyric acid signaling pathway (GO:0007214)2.81642024
50C4-dicarboxylate transport (GO:0015740)2.81093644
51synapse organization (GO:0050808)2.80731481
52behavioral response to nicotine (GO:0035095)2.79693024
53sodium ion export (GO:0071436)2.79387128
54negative regulation of axon guidance (GO:1902668)2.79277792
55cell differentiation in hindbrain (GO:0021533)2.78244973
56synaptic transmission, glutamatergic (GO:0035249)2.77746996
57negative regulation of axonogenesis (GO:0050771)2.76795784
58myelination in peripheral nervous system (GO:0022011)2.74429068
59peripheral nervous system axon ensheathment (GO:0032292)2.74429068
60synapse assembly (GO:0007416)2.73492953
61positive regulation of synapse assembly (GO:0051965)2.73187609
62apical protein localization (GO:0045176)2.72052232
63neurotransmitter-gated ion channel clustering (GO:0072578)2.70897229
64long-term synaptic potentiation (GO:0060291)2.70807297
65neuron-neuron synaptic transmission (GO:0007270)2.68705725
66potassium ion homeostasis (GO:0055075)2.68427976
67regulation of axon extension involved in axon guidance (GO:0048841)2.68210380
68mechanosensory behavior (GO:0007638)2.68028323
69regulation of axon guidance (GO:1902667)2.66630288
70pyrimidine nucleobase catabolic process (GO:0006208)2.66552911
71regulation of glutamate receptor signaling pathway (GO:1900449)2.66249057
72dendritic spine organization (GO:0097061)2.65218851
73hippocampus development (GO:0021766)2.65166896
74nonmotile primary cilium assembly (GO:0035058)2.65055484
75membrane hyperpolarization (GO:0060081)2.63639975
76regulation of synapse structural plasticity (GO:0051823)2.63562833
77axon ensheathment in central nervous system (GO:0032291)2.62711397
78central nervous system myelination (GO:0022010)2.62711397
79neuromuscular process controlling balance (GO:0050885)2.61951848
80neuronal action potential propagation (GO:0019227)2.61881295
81synaptic vesicle endocytosis (GO:0048488)2.61133839
82adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60939634
83myelination (GO:0042552)2.60706359
84semaphorin-plexin signaling pathway (GO:0071526)2.60389587
85spinal cord development (GO:0021510)2.60200603
86presynaptic membrane assembly (GO:0097105)2.59981002
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.58892942
88activated T cell proliferation (GO:0050798)2.57894999
89cerebral cortex radially oriented cell migration (GO:0021799)2.56741852
90presynaptic membrane organization (GO:0097090)2.56683704
91ganglion development (GO:0061548)2.56645210
92asymmetric protein localization (GO:0008105)2.55032255
93intraciliary transport (GO:0042073)2.54053840
94axon extension (GO:0048675)2.53957770
95ensheathment of neurons (GO:0007272)2.53749075
96axon ensheathment (GO:0008366)2.53749075
97regulation of neuronal synaptic plasticity (GO:0048168)2.53581076
98positive regulation of neurological system process (GO:0031646)2.52108881
99photoreceptor cell differentiation (GO:0046530)2.51690798
100eye photoreceptor cell differentiation (GO:0001754)2.51690798
101positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.50320035
102gamma-aminobutyric acid transport (GO:0015812)2.47955231
103cell communication by electrical coupling (GO:0010644)2.45447680
104central nervous system neuron axonogenesis (GO:0021955)2.45418500
105adult walking behavior (GO:0007628)2.44744965
106negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.44425005
107homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.44392655
108regulation of dendritic spine morphogenesis (GO:0061001)2.43832857
109axon extension involved in axon guidance (GO:0048846)2.43070249
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.43070249
111appendage development (GO:0048736)2.42456999
112limb development (GO:0060173)2.42456999
113neuron projection morphogenesis (GO:0048812)2.41913887
114startle response (GO:0001964)2.41835824
115regulation of neuron migration (GO:2001222)2.40716744
116regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40700267
117regulation of synapse assembly (GO:0051963)2.40528688
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.40305709
119vesicle transport along microtubule (GO:0047496)2.38093190
120regulation of collateral sprouting (GO:0048670)2.37975152
121regulation of action potential (GO:0098900)2.37239472
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.36926249
123negative regulation of neurotransmitter secretion (GO:0046929)2.36862748
124dendrite development (GO:0016358)2.36558277
125postsynaptic membrane organization (GO:0001941)2.36428010
126epithelial cilium movement (GO:0003351)2.34802599
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34461052
128olfactory bulb development (GO:0021772)2.32956658
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.31721893
130response to auditory stimulus (GO:0010996)2.31524763
131glycosphingolipid biosynthetic process (GO:0006688)2.29441813
132neuron migration (GO:0001764)2.27354158
133neuromuscular synaptic transmission (GO:0007274)2.26961061
134prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.25081085
135cilium movement (GO:0003341)2.24266558
136axonogenesis (GO:0007409)2.22384455
137ephrin receptor signaling pathway (GO:0048013)2.21513257
138sex differentiation (GO:0007548)2.18388351
139cytoskeleton-dependent intracellular transport (GO:0030705)2.18230761
140establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.18229477
141mitochondrion transport along microtubule (GO:0047497)2.18229477
142axonemal dynein complex assembly (GO:0070286)2.17358845
143righting reflex (GO:0060013)2.16693048
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.16195698
145negative chemotaxis (GO:0050919)2.15500689
146cranial nerve morphogenesis (GO:0021602)2.14286717
147cilium assembly (GO:0042384)2.13694040
148neuron projection extension (GO:1990138)2.12865307
149cochlea development (GO:0090102)2.12567405
150positive regulation of action potential (GO:0045760)2.11952713
151ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.11760087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.44760707
2GBX2_23144817_ChIP-Seq_PC3_Human2.73827725
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56733736
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45349249
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45164480
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.43854563
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.36916875
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.36916875
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.28943456
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24521304
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21918258
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21768578
13DROSHA_22980978_ChIP-Seq_HELA_Human2.17976878
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15293782
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14469706
16RNF2_27304074_Chip-Seq_ESCs_Mouse2.13300453
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.11326597
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.09783011
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.07902046
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05453705
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99990857
22REST_21632747_ChIP-Seq_MESCs_Mouse1.99193983
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98882781
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97860739
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93762245
26AR_21572438_ChIP-Seq_LNCaP_Human1.91838691
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79161783
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.71910343
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67381595
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66391673
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65368882
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63837855
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62337623
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60899433
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60618904
36ZNF274_21170338_ChIP-Seq_K562_Hela1.60557953
37* RARB_27405468_Chip-Seq_BRAIN_Mouse1.60528445
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57103672
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57062555
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.56509183
41TAF15_26573619_Chip-Seq_HEK293_Human1.54330720
42VDR_22108803_ChIP-Seq_LS180_Human1.52642512
43EWS_26573619_Chip-Seq_HEK293_Human1.52532247
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50816228
45SMAD4_21799915_ChIP-Seq_A2780_Human1.49023915
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46195171
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43717278
48* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42193164
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42150539
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41055930
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39047729
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.37722541
53RNF2_27304074_Chip-Seq_NSC_Mouse1.37073802
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35842787
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.33808413
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.33252721
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.30999719
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.29589560
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28513979
60* STAT3_23295773_ChIP-Seq_U87_Human1.28235131
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27621563
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26683857
63AHR_22903824_ChIP-Seq_MCF-7_Human1.26280169
64* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24900113
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24845047
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24676118
67* AR_19668381_ChIP-Seq_PC3_Human1.24240300
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24130637
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.23006411
70* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21009622
71* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21009622
72P300_19829295_ChIP-Seq_ESCs_Human1.20759446
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.20590907
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20548024
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20440354
76MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19712377
77* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18566759
78STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18295485
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17959628
80IGF1R_20145208_ChIP-Seq_DFB_Human1.17171579
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.16885081
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16435371
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15839156
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15583474
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13693480
86EP300_21415370_ChIP-Seq_HL-1_Mouse1.12469359
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11771743
88TCF4_23295773_ChIP-Seq_U87_Human1.11672291
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11307829
90AR_25329375_ChIP-Seq_VCAP_Human1.08872633
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08370352
92* SOX9_26525672_Chip-Seq_HEART_Mouse1.06298045
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06183611
94ER_23166858_ChIP-Seq_MCF-7_Human1.06062562
95SMAD_19615063_ChIP-ChIP_OVARY_Human1.05848182
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05459028
97RUNX2_22187159_ChIP-Seq_PCA_Human1.05239394
98FUS_26573619_Chip-Seq_HEK293_Human1.04652368
99IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04203533
100SMAD3_21741376_ChIP-Seq_ESCs_Human1.04049970
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03749153
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03268376
103* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03171030
104* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01928437
105IRF1_19129219_ChIP-ChIP_H3396_Human1.01890911
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.00814513
107FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00701601
108* ISL1_27105846_Chip-Seq_CPCs_Mouse0.99898358
109TP63_19390658_ChIP-ChIP_HaCaT_Human0.99044432
110DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98491386
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97474044
112CBP_20019798_ChIP-Seq_JUKART_Human0.97474044
113KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.97274353
114TP53_16413492_ChIP-PET_HCT116_Human0.96769476
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96101112
116CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96079874
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96028132
118TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95466255
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95206756
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.94341586
121* BCAT_22108803_ChIP-Seq_LS180_Human0.94321732
122GATA1_26923725_Chip-Seq_HPCs_Mouse0.94096798
123RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93625149
124* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92698821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.72597483
2MP0003880_abnormal_central_pattern2.87034263
3MP0003635_abnormal_synaptic_transmissio2.66170732
4MP0000778_abnormal_nervous_system2.63504168
5MP0004270_analgesia2.62757658
6MP0005171_absent_coat_pigmentation2.48605203
7MP0009046_muscle_twitch2.41294426
8MP0004885_abnormal_endolymph2.25613422
9MP0001984_abnormal_olfaction2.20703676
10MP0002653_abnormal_ependyma_morphology2.19168469
11MP0002063_abnormal_learning/memory/cond2.11399068
12MP0002064_seizures2.08827793
13MP0001486_abnormal_startle_reflex2.04743915
14MP0005623_abnormal_meninges_morphology2.01122322
15MP0005423_abnormal_somatic_nervous1.98726184
16MP0002734_abnormal_mechanical_nocicepti1.95114579
17MP0002272_abnormal_nervous_system1.91763189
18MP0009745_abnormal_behavioral_response1.91621830
19MP0002184_abnormal_innervation1.90787203
20MP0002822_catalepsy1.88210732
21MP0005551_abnormal_eye_electrophysiolog1.82744727
22MP0002572_abnormal_emotion/affect_behav1.76166964
23MP0004742_abnormal_vestibular_system1.69909529
24MP0001188_hyperpigmentation1.64719585
25MP0002067_abnormal_sensory_capabilities1.60781556
26MP0000955_abnormal_spinal_cord1.60660896
27MP0008569_lethality_at_weaning1.60433657
28MP0002882_abnormal_neuron_morphology1.57956368
29MP0002638_abnormal_pupillary_reflex1.57285385
30MP0002557_abnormal_social/conspecific_i1.55928177
31MP0001299_abnormal_eye_distance/1.55663611
32MP0001440_abnormal_grooming_behavior1.55198688
33MP0000566_synostosis1.54733412
34MP0003787_abnormal_imprinting1.50761345
35MP0004145_abnormal_muscle_electrophysio1.49726100
36MP0001968_abnormal_touch/_nociception1.45269141
37MP0000569_abnormal_digit_pigmentation1.43775786
38MP0006072_abnormal_retinal_apoptosis1.42449639
39MP0003122_maternal_imprinting1.41354767
40MP0009780_abnormal_chondrocyte_physiolo1.37755415
41MP0005187_abnormal_penis_morphology1.37342458
42MP0005499_abnormal_olfactory_system1.35728188
43MP0005394_taste/olfaction_phenotype1.35728188
44MP0002152_abnormal_brain_morphology1.35500340
45MP0000631_abnormal_neuroendocrine_gland1.33592560
46MP0003938_abnormal_ear_development1.32038778
47MP0004811_abnormal_neuron_physiology1.31067427
48MP0000049_abnormal_middle_ear1.30614834
49MP0003385_abnormal_body_wall1.29276307
50MP0001502_abnormal_circadian_rhythm1.28166531
51MP0000537_abnormal_urethra_morphology1.27822605
52MP0004924_abnormal_behavior1.27682224
53MP0005386_behavior/neurological_phenoty1.27682224
54MP0001485_abnormal_pinna_reflex1.27380077
55MP0000920_abnormal_myelination1.26324598
56MP0003634_abnormal_glial_cell1.25253074
57MP0003329_amyloid_beta_deposits1.23122851
58MP0004858_abnormal_nervous_system1.22855538
59MP0002752_abnormal_somatic_nervous1.22809721
60MP0005253_abnormal_eye_physiology1.22571288
61MP0003861_abnormal_nervous_system1.20846032
62MP0008789_abnormal_olfactory_epithelium1.19155020
63MP0002066_abnormal_motor_capabilities/c1.18775031
64MP0003123_paternal_imprinting1.13446287
65MP0000462_abnormal_digestive_system1.13151155
66MP0000427_abnormal_hair_cycle1.12717131
67MP0002733_abnormal_thermal_nociception1.12329987
68MP0003890_abnormal_embryonic-extraembry1.11154810
69MP0006276_abnormal_autonomic_nervous1.10373544
70MP0003632_abnormal_nervous_system1.09390211
71MP0001970_abnormal_pain_threshold1.09291104
72MP0006292_abnormal_olfactory_placode1.08808151
73MP0003119_abnormal_digestive_system1.08341920
74MP0004134_abnormal_chest_morphology1.07356646
75MP0003690_abnormal_glial_cell1.05599222
76MP0005195_abnormal_posterior_eye1.05454358
77MP0000534_abnormal_ureter_morphology1.05291306
78MP0002090_abnormal_vision1.05216120
79MP0002736_abnormal_nociception_after1.04230551
80MP0008877_abnormal_DNA_methylation1.03557660
81MP0004133_heterotaxia1.02744547
82MP0005248_abnormal_Harderian_gland1.02252378
83MP0003121_genomic_imprinting1.02159999
84MP0005645_abnormal_hypothalamus_physiol1.00655964
85MP0002234_abnormal_pharynx_morphology0.99460375
86MP0001529_abnormal_vocalization0.98831969
87MP0000026_abnormal_inner_ear0.98572403
88MP0002909_abnormal_adrenal_gland0.98539430
89MP0004233_abnormal_muscle_weight0.97907108
90MP0002229_neurodegeneration0.96410859
91MP0000372_irregular_coat_pigmentation0.93686623
92MP0003942_abnormal_urinary_system0.92270221
93MP0000383_abnormal_hair_follicle0.92039767
94MP0002735_abnormal_chemical_nociception0.91537527
95MP0003937_abnormal_limbs/digits/tail_de0.91491709
96MP0001177_atelectasis0.90281554
97MP0001293_anophthalmia0.89695334
98MP0005646_abnormal_pituitary_gland0.88735647
99MP0005410_abnormal_fertilization0.88608136
100MP0003283_abnormal_digestive_organ0.87344669
101MP0002160_abnormal_reproductive_system0.86154153
102MP0001963_abnormal_hearing_physiology0.85410857
103MP0010030_abnormal_orbit_morphology0.85036051
104MP0001324_abnormal_eye_pigmentation0.84186654
105MP0003935_abnormal_craniofacial_develop0.83173852
106MP0002081_perinatal_lethality0.82551823
107MP0002102_abnormal_ear_morphology0.82463372
108MP0002751_abnormal_autonomic_nervous0.82086275
109MP0002938_white_spotting0.78841871
110MP0003698_abnormal_male_reproductive0.78609745
111MP0002697_abnormal_eye_size0.78536280
112MP0002249_abnormal_larynx_morphology0.77387845
113MP0008995_early_reproductive_senescence0.76836244
114MP0002210_abnormal_sex_determination0.76809457
115MP0002116_abnormal_craniofacial_bone0.76735190
116MP0005391_vision/eye_phenotype0.76714128
117MP0002233_abnormal_nose_morphology0.76481862
118MP0002089_abnormal_postnatal_growth/wei0.75095492
119MP0003631_nervous_system_phenotype0.74371682
120MP0009250_abnormal_appendicular_skeleto0.74169053
121MP0000013_abnormal_adipose_tissue0.73258947
122MP0004142_abnormal_muscle_tone0.72675180
123MP0003755_abnormal_palate_morphology0.72154316
124MP0003136_yellow_coat_color0.71212818

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)3.35551479
2Progressive cerebellar ataxia (HP:0002073)3.32727795
3Focal motor seizures (HP:0011153)3.26433902
4Action tremor (HP:0002345)3.23184096
5Focal seizures (HP:0007359)3.14556730
6Abnormality of the corticospinal tract (HP:0002492)2.96024804
7Epileptic encephalopathy (HP:0200134)2.89209039
8Myokymia (HP:0002411)2.88119903
9Visual hallucinations (HP:0002367)2.86265544
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.72817336
11Degeneration of the lateral corticospinal tracts (HP:0002314)2.72817336
12Ankle clonus (HP:0011448)2.43252431
13Cortical dysplasia (HP:0002539)2.41675800
14Absence seizures (HP:0002121)2.39310898
15Supranuclear gaze palsy (HP:0000605)2.39214745
16Blue irides (HP:0000635)2.39056392
17Megalencephaly (HP:0001355)2.36471509
18Termporal pattern (HP:0011008)2.34119522
19Insidious onset (HP:0003587)2.34119522
20Chronic hepatic failure (HP:0100626)2.30028330
21Central scotoma (HP:0000603)2.30020374
22Gaze-evoked nystagmus (HP:0000640)2.29419724
23Spastic gait (HP:0002064)2.29363472
24Febrile seizures (HP:0002373)2.28798984
25Hypoplastic nipples (HP:0002557)2.28708468
26Lissencephaly (HP:0001339)2.26805312
27Broad-based gait (HP:0002136)2.26390727
28Nephrogenic diabetes insipidus (HP:0009806)2.25386253
29Pancreatic cysts (HP:0001737)2.25272806
30Pancreatic fibrosis (HP:0100732)2.24994151
31Abnormality of macular pigmentation (HP:0008002)2.23721812
32Congenital stationary night blindness (HP:0007642)2.23153171
33Nephronophthisis (HP:0000090)2.22801223
34True hermaphroditism (HP:0010459)2.21712561
35Genetic anticipation (HP:0003743)2.18833055
36Drooling (HP:0002307)2.18348184
37Excessive salivation (HP:0003781)2.18348184
38Dysdiadochokinesis (HP:0002075)2.18341058
39Scanning speech (HP:0002168)2.11796653
40Intention tremor (HP:0002080)2.10261360
41Dysmetria (HP:0001310)2.09539160
42Truncal ataxia (HP:0002078)2.09229503
43Abnormality of the parathyroid morphology (HP:0011766)2.07441555
44Aqueductal stenosis (HP:0002410)2.05430810
45Papillary thyroid carcinoma (HP:0002895)2.05183882
46Occipital encephalocele (HP:0002085)2.05020698
47Poor coordination (HP:0002370)2.04664775
48Dialeptic seizures (HP:0011146)2.03621750
49Tubulointerstitial nephritis (HP:0001970)2.01990355
50Limb dystonia (HP:0002451)1.99983601
51Abnormality of the lower motor neuron (HP:0002366)1.97426810
52Abnormality of the labia minora (HP:0012880)1.97330214
53Fetal akinesia sequence (HP:0001989)1.95539706
54Gait imbalance (HP:0002141)1.94109079
55Hemiparesis (HP:0001269)1.93660770
56Retinal dysplasia (HP:0007973)1.93453480
57Pheochromocytoma (HP:0002666)1.93240654
58Depression (HP:0000716)1.93062772
59Neurofibrillary tangles (HP:0002185)1.92479838
60Concave nail (HP:0001598)1.90873517
61Oligodactyly (hands) (HP:0001180)1.89560738
62Abnormality of midbrain morphology (HP:0002418)1.89205362
63Molar tooth sign on MRI (HP:0002419)1.89205362
64Lower limb muscle weakness (HP:0007340)1.88160274
65Patellar aplasia (HP:0006443)1.86480107
66Hypoplasia of the brainstem (HP:0002365)1.86056167
67Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86056167
68Absent speech (HP:0001344)1.84747549
69Aplasia/Hypoplasia of the sternum (HP:0006714)1.84237190
70Abnormality of the astrocytes (HP:0100707)1.84039530
71Astrocytoma (HP:0009592)1.84039530
72Hepatoblastoma (HP:0002884)1.83443089
73Curly hair (HP:0002212)1.82783129
74Type II lissencephaly (HP:0007260)1.82765687
75Narrow forehead (HP:0000341)1.82700691
76Abnormality of the renal medulla (HP:0100957)1.81744109
77Midline defect of the nose (HP:0004122)1.80405462
78High anterior hairline (HP:0009890)1.80258527
79Generalized tonic-clonic seizures (HP:0002069)1.78403511
80Intellectual disability, moderate (HP:0002342)1.77700459
81Postaxial hand polydactyly (HP:0001162)1.76170525
82Urinary urgency (HP:0000012)1.75964252
83Volvulus (HP:0002580)1.75779598
84Anteriorly placed anus (HP:0001545)1.75398777
85Agitation (HP:0000713)1.74656706
86Akinesia (HP:0002304)1.73629578
87Shawl scrotum (HP:0000049)1.73588426
88Macroorchidism (HP:0000053)1.73582193
89Overriding aorta (HP:0002623)1.73344387
90Specific learning disability (HP:0001328)1.73316061
91Preaxial hand polydactyly (HP:0001177)1.73245470
92Impaired vibration sensation in the lower limbs (HP:0002166)1.73090704
93EEG with generalized epileptiform discharges (HP:0011198)1.72819095
94Aplasia/Hypoplasia of the patella (HP:0006498)1.72604016
95Aplasia involving bones of the extremities (HP:0009825)1.72507780
96Aplasia involving bones of the upper limbs (HP:0009823)1.72507780
97Aplasia of the phalanges of the hand (HP:0009802)1.72507780
98Neoplasm of the heart (HP:0100544)1.72477946
99Septo-optic dysplasia (HP:0100842)1.71903751
100Insomnia (HP:0100785)1.71453063
101Urinary bladder sphincter dysfunction (HP:0002839)1.69956635
102Polyphagia (HP:0002591)1.69153963
103Spastic tetraplegia (HP:0002510)1.68541332
104Abnormal respiratory motile cilium physiology (HP:0012261)1.68128889
105Cystic liver disease (HP:0006706)1.67997872
106Morphological abnormality of the pyramidal tract (HP:0002062)1.67724198
107Sensory axonal neuropathy (HP:0003390)1.67693027
108Epileptiform EEG discharges (HP:0011182)1.67203666
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65770542
110Abnormal respiratory epithelium morphology (HP:0012253)1.65422452
111Abnormal respiratory motile cilium morphology (HP:0005938)1.65422452
112Polymicrogyria (HP:0002126)1.65320707
113Vaginal atresia (HP:0000148)1.65252382
114Cerebral inclusion bodies (HP:0100314)1.65185225
115Pachygyria (HP:0001302)1.64322549
116Aplasia/Hypoplasia of the tongue (HP:0010295)1.64279719
117Rhinitis (HP:0012384)1.64012315
118Anencephaly (HP:0002323)1.63959098
119Buphthalmos (HP:0000557)1.63457364
120Scotoma (HP:0000575)1.63073655
121Postaxial foot polydactyly (HP:0001830)1.63017614
122Oligodactyly (HP:0012165)1.62170922
123Genital tract atresia (HP:0001827)1.61363671
124Micropenis (HP:0000054)1.61216939
125Hypsarrhythmia (HP:0002521)1.61120536
126Cerebellar dysplasia (HP:0007033)1.60796339
127Renal hypoplasia (HP:0000089)1.60742443
128Morphological abnormality of the middle ear (HP:0008609)1.60725375
129Lower limb asymmetry (HP:0100559)1.60392575
130Deep palmar crease (HP:0006191)1.60184898
131Hypoplasia of the corpus callosum (HP:0002079)1.60122599
132Mutism (HP:0002300)1.59772818
133Sclerocornea (HP:0000647)1.59743251
134Cutaneous finger syndactyly (HP:0010554)1.59401407
135Congenital primary aphakia (HP:0007707)1.59366284
136Amyotrophic lateral sclerosis (HP:0007354)1.59058981
137Narrow nasal bridge (HP:0000446)1.58625530
138Abnormal eating behavior (HP:0100738)1.58438304
139Amblyopia (HP:0000646)1.58422251
140Abnormality of ocular smooth pursuit (HP:0000617)1.57952034
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.57839632
142Renal dysplasia (HP:0000110)1.57787650
143Labial hypoplasia (HP:0000066)1.57642548
144Bicornuate uterus (HP:0000813)1.56296699
145Shallow orbits (HP:0000586)1.56127894
146Alacrima (HP:0000522)1.55523041
147Protruding tongue (HP:0010808)1.55463360
148Glioma (HP:0009733)1.55452301
149Pointed chin (HP:0000307)1.53870951
150Neuroendocrine neoplasm (HP:0100634)1.53739340
151Optic nerve hypoplasia (HP:0000609)1.53666670
152Hyperventilation (HP:0002883)1.53437783
153Open mouth (HP:0000194)1.52885831
154Medial flaring of the eyebrow (HP:0010747)1.52034841
155Clonus (HP:0002169)1.51707886
156Scapular winging (HP:0003691)1.51697822
157Exotropia (HP:0000577)1.51488547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.75103314
2TYRO33.19428095
3TNIK2.64587616
4PAK62.43306952
5MAP3K42.32919434
6TRIM282.30650470
7AKT32.21623432
8NTRK32.19968245
9STK392.11634287
10MAPK132.09187165
11PRPF4B2.07750243
12MINK11.90794365
13ICK1.90460311
14NTRK21.85749589
15MAP3K91.78214952
16KSR11.74173728
17FGFR21.73892633
18FRK1.73297414
19ERBB31.68536028
20OXSR11.63391666
21UHMK11.58867076
22BCR1.56637480
23EPHA41.55827080
24PAK31.50864600
25CASK1.49269070
26PRKD31.38772175
27PNCK1.35791858
28MAP2K71.35491872
29EPHB11.31080723
30WNK11.26541377
31SGK2231.26246869
32SGK4941.26246869
33DYRK31.24481249
34STK38L1.16226927
35SRPK11.15898861
36FES1.13257563
37PHKG11.12675471
38PHKG21.12675471
39PKN11.11772170
40NTRK11.10821908
41LATS11.10726998
42KSR21.09731626
43CDK51.09588431
44CAMK1G1.08450154
45EPHB21.08207230
46IRAK21.07241288
47PDGFRA1.05660008
48ROCK21.04363689
49LIMK11.03381539
50PLK21.03299256
51CAMKK11.03072007
52RET1.02163049
53PINK11.01140486
54DYRK21.01036281
55WNK41.00689320
56ROCK11.00429766
57BMPR1B0.96696383
58CAMKK20.94523087
59MKNK20.93820396
60MAP2K40.93515048
61PKN20.92745935
62LMTK20.90934462
63DYRK1A0.88952848
64PDGFRB0.87958028
65CSNK1G20.87291135
66PTK20.87287474
67MAP3K20.87255831
68LATS20.86071969
69CDK140.85064089
70STK380.84549238
71WNK30.84137905
72GRK10.84087839
73CSNK1A1L0.83337406
74NEK60.80893747
75SIK20.80882254
76DDR20.79262530
77DMPK0.79062129
78CDK180.78761856
79FER0.77857253
80SGK20.76165701
81RIPK10.75966331
82CDK150.75940185
83PIK3CA0.75882326
84MARK20.75358922
85DAPK20.73321426
86PRKCG0.70830334
87CSNK1G30.70441831
88CDK190.69118052
89MET0.67313788
90FGFR10.67073880
91ERBB20.66550869
92MKNK10.63952308
93CAMK2A0.63734208
94BRD40.62778946
95CDK11A0.61885662
96EPHA30.59628269
97STK110.58976870
98RPS6KA40.58149181
99TAF10.57749821
100SGK30.57263169
101CAMK2D0.56880878
102PRKCH0.56682875
103CSNK1E0.56147516
104CAMK2B0.53562964
105RPS6KA20.53484740
106CDC42BPA0.52380636
107CSNK1G10.52098252
108INSRR0.51260093
109DYRK1B0.50599486
110BMX0.50273228
111PTK60.49068343
112PRKCE0.48611425
113TRIB30.48399836
114MAP4K20.48390226
115RPS6KB10.48224852
116CSNK1D0.48116694
117SGK10.48077802
118PTK2B0.45469943
119MAPK100.45363710
120IRAK10.45256504
121CDK30.45202622
122PRKCZ0.44867335
123PRKAA10.44844081
124FYN0.44093075
125CAMK10.42326487
126BRSK20.42014709
127CCNB10.40042270
128PRKACB0.40000950
129CAMK1D0.38293328
130CAMK40.38134824
131ATR0.37467647
132MAPK90.37215874
133MAP3K60.37100139
134GSK3B0.36938260
135PRKCI0.36520692
136TIE10.36478275

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.91716208
2Synaptic vesicle cycle_Homo sapiens_hsa047212.69126228
3GABAergic synapse_Homo sapiens_hsa047272.34516561
4Glutamatergic synapse_Homo sapiens_hsa047242.30692336
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23319025
6Axon guidance_Homo sapiens_hsa043602.22386639
7Circadian entrainment_Homo sapiens_hsa047132.11085070
8Morphine addiction_Homo sapiens_hsa050321.97183600
9Long-term potentiation_Homo sapiens_hsa047201.84453948
10Dopaminergic synapse_Homo sapiens_hsa047281.83972537
11* Cholinergic synapse_Homo sapiens_hsa047251.75911434
12Long-term depression_Homo sapiens_hsa047301.74053947
13Olfactory transduction_Homo sapiens_hsa047401.68033551
14Butanoate metabolism_Homo sapiens_hsa006501.66222840
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64042459
16Salivary secretion_Homo sapiens_hsa049701.58205073
17Amphetamine addiction_Homo sapiens_hsa050311.55062347
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54954564
19Insulin secretion_Homo sapiens_hsa049111.52614603
20Serotonergic synapse_Homo sapiens_hsa047261.47510954
21Gastric acid secretion_Homo sapiens_hsa049711.45436443
22Renin secretion_Homo sapiens_hsa049241.42581385
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42012570
24Gap junction_Homo sapiens_hsa045401.40613818
25* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38000836
26Taste transduction_Homo sapiens_hsa047421.37602226
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34780755
28* Oxytocin signaling pathway_Homo sapiens_hsa049211.33611435
29Propanoate metabolism_Homo sapiens_hsa006401.31780589
30* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26486372
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26397163
32Phototransduction_Homo sapiens_hsa047441.25540209
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25332713
34Collecting duct acid secretion_Homo sapiens_hsa049661.25284573
35Melanogenesis_Homo sapiens_hsa049161.20917466
36GnRH signaling pathway_Homo sapiens_hsa049121.18454100
37Cocaine addiction_Homo sapiens_hsa050301.16326819
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15979113
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15678281
40Vibrio cholerae infection_Homo sapiens_hsa051101.14071624
41Dorso-ventral axis formation_Homo sapiens_hsa043201.13537091
42* Renal cell carcinoma_Homo sapiens_hsa052111.12368500
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11353307
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09821737
45Basal transcription factors_Homo sapiens_hsa030221.08788635
46Hedgehog signaling pathway_Homo sapiens_hsa043401.05794486
47* Type II diabetes mellitus_Homo sapiens_hsa049301.05036323
48beta-Alanine metabolism_Homo sapiens_hsa004101.04183924
49* ErbB signaling pathway_Homo sapiens_hsa040121.04088864
50* Estrogen signaling pathway_Homo sapiens_hsa049151.03969904
51Tight junction_Homo sapiens_hsa045301.02094816
52Hippo signaling pathway_Homo sapiens_hsa043901.01979521
53Oocyte meiosis_Homo sapiens_hsa041141.01883863
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01031914
55* cAMP signaling pathway_Homo sapiens_hsa040241.00667861
56* Phospholipase D signaling pathway_Homo sapiens_hsa040720.98256822
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96981846
58* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96961964
59* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96633136
60Basal cell carcinoma_Homo sapiens_hsa052170.96452396
61Wnt signaling pathway_Homo sapiens_hsa043100.96389897
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96372969
63* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95502782
64Calcium signaling pathway_Homo sapiens_hsa040200.94287140
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94008944
66* Glioma_Homo sapiens_hsa052140.93521764
67* Endometrial cancer_Homo sapiens_hsa052130.92372314
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.92029030
69Circadian rhythm_Homo sapiens_hsa047100.91973289
70Lysine degradation_Homo sapiens_hsa003100.90753333
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89340861
72Thyroid hormone synthesis_Homo sapiens_hsa049180.88598165
73Fatty acid metabolism_Homo sapiens_hsa012120.87936376
74Dilated cardiomyopathy_Homo sapiens_hsa054140.87852372
75* Choline metabolism in cancer_Homo sapiens_hsa052310.86985156
76* AMPK signaling pathway_Homo sapiens_hsa041520.86553034
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86144602
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85517503
79Protein export_Homo sapiens_hsa030600.84915861
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83891679
81Ether lipid metabolism_Homo sapiens_hsa005650.83529914
82mRNA surveillance pathway_Homo sapiens_hsa030150.83074697
83* Colorectal cancer_Homo sapiens_hsa052100.82628176
84Pancreatic secretion_Homo sapiens_hsa049720.78574637
85Fanconi anemia pathway_Homo sapiens_hsa034600.78206192
86Endocytosis_Homo sapiens_hsa041440.75329218
87MAPK signaling pathway_Homo sapiens_hsa040100.75005159
88* Ras signaling pathway_Homo sapiens_hsa040140.73631221
89* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71919690
90Adherens junction_Homo sapiens_hsa045200.71194371
91Cardiac muscle contraction_Homo sapiens_hsa042600.70373206
92* Focal adhesion_Homo sapiens_hsa045100.70320439
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69896877
94* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68909205
95Alcoholism_Homo sapiens_hsa050340.68274032
96Ovarian steroidogenesis_Homo sapiens_hsa049130.65300310
97Fatty acid biosynthesis_Homo sapiens_hsa000610.64462872
98* mTOR signaling pathway_Homo sapiens_hsa041500.64135785
99Huntingtons disease_Homo sapiens_hsa050160.63391981
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62226727
101Regulation of autophagy_Homo sapiens_hsa041400.61926175
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61669199
103* Proteoglycans in cancer_Homo sapiens_hsa052050.61029725
104MicroRNAs in cancer_Homo sapiens_hsa052060.60825342
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60656791
106Inositol phosphate metabolism_Homo sapiens_hsa005620.60012345
107* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57996403
108* Sphingolipid signaling pathway_Homo sapiens_hsa040710.55968694
109* Rap1 signaling pathway_Homo sapiens_hsa040150.55833484
110* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55717423
111* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54617896
112* VEGF signaling pathway_Homo sapiens_hsa043700.54615973
113Tryptophan metabolism_Homo sapiens_hsa003800.53829552
114Linoleic acid metabolism_Homo sapiens_hsa005910.53433760
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53180811
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53018152
117ECM-receptor interaction_Homo sapiens_hsa045120.52899563
118RNA transport_Homo sapiens_hsa030130.51273233
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50789149
120* Neurotrophin signaling pathway_Homo sapiens_hsa047220.50376801
121Steroid biosynthesis_Homo sapiens_hsa001000.50068899
122* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49713059
123Selenocompound metabolism_Homo sapiens_hsa004500.49470877
124Phenylalanine metabolism_Homo sapiens_hsa003600.48425393
125Glucagon signaling pathway_Homo sapiens_hsa049220.47636467
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.47579679
127* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45791866
128* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45576608
129ABC transporters_Homo sapiens_hsa020100.45563699
130Fatty acid elongation_Homo sapiens_hsa000620.45150424
131Notch signaling pathway_Homo sapiens_hsa043300.44890009
132Arginine and proline metabolism_Homo sapiens_hsa003300.44667650
133* Pancreatic cancer_Homo sapiens_hsa052120.42930514

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