PIK3R4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)6.00181514
2DNA synthesis involved in DNA repair (GO:0000731)5.38405327
3negative regulation of histone methylation (GO:0031061)4.86574694
4regulation of translational fidelity (GO:0006450)4.38415260
5COPI coating of Golgi vesicle (GO:0048205)4.33568941
6Golgi transport vesicle coating (GO:0048200)4.33568941
7histone H3-K36 demethylation (GO:0070544)4.25248095
8protein localization to chromosome, centromeric region (GO:0071459)4.10546257
9mitotic metaphase plate congression (GO:0007080)4.06911896
10sister chromatid segregation (GO:0000819)4.04855688
11negative regulation of DNA repair (GO:0045738)3.99934333
12mitotic sister chromatid segregation (GO:0000070)3.94817019
13histone H2A monoubiquitination (GO:0035518)3.93243926
14regulation of centriole replication (GO:0046599)3.89732497
15DNA replication initiation (GO:0006270)3.82583879
16positive regulation of chromosome segregation (GO:0051984)3.68747821
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.68745570
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.68745570
19positive regulation of mitotic sister chromatid separation (GO:1901970)3.68745570
20nuclear pore complex assembly (GO:0051292)3.67910844
21DNA strand elongation involved in DNA replication (GO:0006271)3.63856169
22metaphase plate congression (GO:0051310)3.63772750
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63039556
24peptidyl-lysine dimethylation (GO:0018027)3.59711452
25ribosome assembly (GO:0042255)3.58992971
26regulation of RNA export from nucleus (GO:0046831)3.58456028
27DNA strand elongation (GO:0022616)3.55575641
28histone H4-K8 acetylation (GO:0043982)3.55025615
29histone H4-K5 acetylation (GO:0043981)3.55025615
30gene silencing by RNA (GO:0031047)3.48896288
31histone H4-K12 acetylation (GO:0043983)3.46724947
32positive regulation of histone deacetylation (GO:0031065)3.46234745
33folic acid-containing compound biosynthetic process (GO:0009396)3.44813119
34double-strand break repair via nonhomologous end joining (GO:0006303)3.44125553
35non-recombinational repair (GO:0000726)3.44125553
36sister chromatid cohesion (GO:0007062)3.40934468
37cytoplasmic mRNA processing body assembly (GO:0033962)3.38205524
38regulation of histone H3-K9 methylation (GO:0051570)3.36435568
39regulation of chromosome segregation (GO:0051983)3.36385183
40nuclear pore organization (GO:0006999)3.31269622
41nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.26523340
42regulation of mitotic sister chromatid separation (GO:0010965)3.22943872
43regulation of mitotic sister chromatid segregation (GO:0033047)3.22943872
44regulation of sister chromatid segregation (GO:0033045)3.22943872
45regulation of mitotic metaphase/anaphase transition (GO:0030071)3.22685860
46regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.22685860
47establishment of chromosome localization (GO:0051303)3.21946308
48histone H4-K16 acetylation (GO:0043984)3.20492608
49negative regulation of chromosome segregation (GO:0051985)3.19919281
50DNA conformation change (GO:0071103)3.16879684
51establishment of integrated proviral latency (GO:0075713)3.16612399
52antigen processing and presentation of endogenous antigen (GO:0019883)3.15563797
53regulation of nucleobase-containing compound transport (GO:0032239)3.15466171
54negative regulation of cell size (GO:0045792)3.14381453
55protein complex localization (GO:0031503)3.11590034
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.10425338
57negative regulation of sister chromatid segregation (GO:0033046)3.10425338
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10425338
59negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10425338
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10425338
61COPII vesicle coating (GO:0048208)3.08837432
62chromosome organization involved in meiosis (GO:0070192)3.07272063
63regulation of DNA endoreduplication (GO:0032875)3.06805045
64chromosome condensation (GO:0030261)3.06429737
65activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.05003588
66histone H2A ubiquitination (GO:0033522)3.03297760
67L-alpha-amino acid transmembrane transport (GO:1902475)3.02856001
68cellular protein complex localization (GO:0034629)3.02507214
69regulation of translational termination (GO:0006449)3.01837500
70regulation of helicase activity (GO:0051095)3.01626055
71synapsis (GO:0007129)3.00910437
72gene silencing (GO:0016458)3.00105669
73determination of adult lifespan (GO:0008340)2.99816572
74negative regulation of histone modification (GO:0031057)2.99144807
75antigen processing and presentation via MHC class Ib (GO:0002475)2.99135742
76spindle checkpoint (GO:0031577)2.98764014
77B cell receptor signaling pathway (GO:0050853)2.97433633
78mitotic nuclear envelope disassembly (GO:0007077)2.97134816
79protein export from nucleus (GO:0006611)2.96781441
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.96337488
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96337488
82DNA unwinding involved in DNA replication (GO:0006268)2.96016475
83regulation of mitotic spindle organization (GO:0060236)2.95881936
84regulation of spindle organization (GO:0090224)2.95727331
85glucocorticoid receptor signaling pathway (GO:0042921)2.95488420
86protein localization to chromosome (GO:0034502)2.94924728
87telomere maintenance via semi-conservative replication (GO:0032201)2.94374817
88mitotic spindle checkpoint (GO:0071174)2.93978749
89positive regulation of nuclease activity (GO:0032075)2.93693978
90paraxial mesoderm development (GO:0048339)2.93517985
91meiotic chromosome segregation (GO:0045132)2.92913156
92mitotic spindle assembly checkpoint (GO:0007094)2.92114114
93IMP biosynthetic process (GO:0006188)2.90690262
94membrane disassembly (GO:0030397)2.88952196
95nuclear envelope disassembly (GO:0051081)2.88952196
96spindle assembly checkpoint (GO:0071173)2.88625094
97DNA packaging (GO:0006323)2.88228413
98positive regulation of cell cycle checkpoint (GO:1901978)2.88161902
99DNA topological change (GO:0006265)2.86710085
100telomere maintenance via recombination (GO:0000722)2.86591457
101mitotic recombination (GO:0006312)2.85737562
102regulation of centrosome duplication (GO:0010824)2.83859661
103regulation of NFAT protein import into nucleus (GO:0051532)2.83726394
104IMP metabolic process (GO:0046040)2.82204853
105regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81925450
106positive regulation of SMAD protein import into nucleus (GO:0060391)2.80483785
107regulation of gamma-delta T cell differentiation (GO:0045586)2.80183408
108mitotic G1 DNA damage checkpoint (GO:0031571)2.79645731
109regulation of centrosome cycle (GO:0046605)2.79205491
110negative regulation of chromatin modification (GO:1903309)2.78619439
111regulation of posttranscriptional gene silencing (GO:0060147)2.78397006
112regulation of gene silencing by miRNA (GO:0060964)2.78397006
113regulation of gene silencing by RNA (GO:0060966)2.78397006
114positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.78068386
115piRNA metabolic process (GO:0034587)2.77873207
116nucleus organization (GO:0006997)2.74297044
117retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73984100
118DNA replication-dependent nucleosome organization (GO:0034723)2.73601651
119DNA replication-dependent nucleosome assembly (GO:0006335)2.73601651
120NLS-bearing protein import into nucleus (GO:0006607)2.72537004
121positive thymic T cell selection (GO:0045059)2.70795947
122pore complex assembly (GO:0046931)2.70506024
123positive regulation of Rap GTPase activity (GO:0032854)2.69586668
124chromosome segregation (GO:0007059)2.69257613
125regulation of nuclease activity (GO:0032069)2.69163945
126CENP-A containing nucleosome assembly (GO:0034080)2.69114891
127mRNA transport (GO:0051028)2.69085598
128spliceosomal tri-snRNP complex assembly (GO:0000244)2.68329351
129heterochromatin organization (GO:0070828)2.67652974
130protein localization to kinetochore (GO:0034501)2.63421376
131histone H3-K4 methylation (GO:0051568)2.62643350
132DNA geometric change (GO:0032392)2.61162677
133negative regulation of sodium ion transport (GO:0010766)2.60781966
134regulation of fatty acid beta-oxidation (GO:0031998)2.59749443
135dosage compensation (GO:0007549)2.58831391
136DNA duplex unwinding (GO:0032508)2.58409436
137intestinal epithelial cell development (GO:0060576)2.56757069
138intracellular estrogen receptor signaling pathway (GO:0030520)2.56480366
139negative regulation of bone resorption (GO:0045779)2.55633235
140regulation of sister chromatid cohesion (GO:0007063)2.54384524
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.51795728
142negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.51247519
143DNA methylation (GO:0006306)2.50394955
144DNA alkylation (GO:0006305)2.50394955
145macroautophagy (GO:0016236)2.49825631
146apoptotic cell clearance (GO:0043277)2.49543246
147mitotic chromosome condensation (GO:0007076)2.48964932
148regulation of cholesterol homeostasis (GO:2000188)2.48426165
149sodium ion export (GO:0071436)2.48233399
150JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.48088172
151nuclear envelope organization (GO:0006998)2.47840895
152monoubiquitinated protein deubiquitination (GO:0035520)2.45450578
153mitotic G1/S transition checkpoint (GO:0044819)2.45257330
154synaptonemal complex assembly (GO:0007130)2.45094739
155corticosteroid receptor signaling pathway (GO:0031958)2.44196928
156regulation of chromatin binding (GO:0035561)2.43754509
157histone H4 acetylation (GO:0043967)2.42984472
158fatty acid homeostasis (GO:0055089)2.42357814
159endoplasmic reticulum unfolded protein response (GO:0030968)2.42234928
160vesicle coating (GO:0006901)2.42138126
161stress granule assembly (GO:0034063)2.41200422
162dicarboxylic acid biosynthetic process (GO:0043650)2.40205309
163regulation of hippo signaling (GO:0035330)2.38513744
164histone H3-K9 demethylation (GO:0033169)2.36952643
165positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.36705205
166regulation of histone H3-K27 methylation (GO:0061085)2.36432195
167regulation of translational elongation (GO:0006448)2.34472774
168regulation of B cell receptor signaling pathway (GO:0050855)2.34151506
169positive regulation of gamma-delta T cell activation (GO:0046645)2.33931574
170mitotic sister chromatid cohesion (GO:0007064)2.31847665
171positive regulation of gene expression, epigenetic (GO:0045815)2.30951497
172positive regulation of histone H3-K4 methylation (GO:0051571)2.30719694
173regulation of gamma-delta T cell activation (GO:0046643)2.30509245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.17901152
2MYC_22102868_ChIP-Seq_BL_Human4.22336375
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.13084904
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78380687
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.65353158
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05738901
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.93490648
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.85614641
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.58924079
10PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.52929021
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.32377908
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.21646792
13VDR_21846776_ChIP-Seq_THP-1_Human2.21030626
14TCF7_22412390_ChIP-Seq_EML_Mouse2.20552100
15MYCN_18555785_ChIP-Seq_MESCs_Mouse2.20050897
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15166245
17KDM2B_26808549_Chip-Seq_DND41_Human2.13502390
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11726265
19ZFX_18555785_ChIP-Seq_MESCs_Mouse2.08015441
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.04298231
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00733090
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00212743
23CIITA_25753668_ChIP-Seq_RAJI_Human1.98864795
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95256127
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94462792
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92654890
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91455661
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91304183
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88202781
30* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.86869845
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85771885
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85532230
33CLOCK_20551151_ChIP-Seq_293T_Human1.83604557
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82056972
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.80537084
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80521150
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.79917384
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72970785
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65905459
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64997457
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.62612698
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.60257641
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59885444
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.59492779
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55647770
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53191206
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.50451600
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49407849
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47578583
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47471484
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47199241
52GATA1_22025678_ChIP-Seq_K562_Human1.46375408
53* ELK1_19687146_ChIP-ChIP_HELA_Human1.46056130
54* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44335173
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.43032228
56DCP1A_22483619_ChIP-Seq_HELA_Human1.41797864
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41590687
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41429464
59UTX_26944678_Chip-Seq_JUKART_Human1.40890009
60MAF_26560356_Chip-Seq_TH1_Human1.40495726
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38175789
62ZNF263_19887448_ChIP-Seq_K562_Human1.36598929
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35121927
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33630872
65SPI1_23127762_ChIP-Seq_K562_Human1.33027849
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32832058
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31751976
68* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31511388
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.31239780
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31019935
71* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30963153
72LXR_22292898_ChIP-Seq_THP-1_Human1.29969046
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29697000
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28724772
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26792576
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24322318
77KDM2B_26808549_Chip-Seq_K562_Human1.23788550
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.22521725
79ATF3_27146783_Chip-Seq_COLON_Human1.22221089
80MYB_26560356_Chip-Seq_TH1_Human1.21231054
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.20888548
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.20410821
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19866669
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.19657743
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.19621351
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19568787
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.18696689
88TFEB_21752829_ChIP-Seq_HELA_Human1.17978075
89FOXO3_23340844_ChIP-Seq_DLD1_Human1.17770569
90* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17663361
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17390890
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17188107
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16826309
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.16217577
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16087363
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14340810
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14229129
98XRN2_22483619_ChIP-Seq_HELA_Human1.14187597
99RACK7_27058665_Chip-Seq_MCF-7_Human1.14052501
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13470928
101E2F1_21310950_ChIP-Seq_MCF-7_Human1.12473481
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11897226
103KDM5A_27292631_Chip-Seq_BREAST_Human1.11100407
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10812280
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10306389
106IRF8_22096565_ChIP-ChIP_GC-B_Human1.10190542
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09409217
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09409217
109NCOR1_26117541_ChIP-Seq_K562_Human1.09020958
110FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08767367
111EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08117163
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.07924041
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07508609
114MYB_26560356_Chip-Seq_TH2_Human1.07206344
115RARB_27405468_Chip-Seq_BRAIN_Mouse1.06766927
116TTF2_22483619_ChIP-Seq_HELA_Human1.06541277
117* GATA3_27048872_Chip-Seq_THYMUS_Human1.04889263
118POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04406459
119CREB1_26743006_Chip-Seq_LNCaP_Human1.03652111
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03301203
121FOXP3_21729870_ChIP-Seq_TREG_Human1.03098830
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01994889
123LXR_22158963_ChIP-Seq_LIVER_Mouse1.01718679
124VDR_24763502_ChIP-Seq_THP-1_Human1.01420298
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00689576
126VDR_23849224_ChIP-Seq_CD4+_Human1.00487975
127ELF1_20517297_ChIP-Seq_JURKAT_Human0.99128906
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97627376
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97411497
130RUNX1_27514584_Chip-Seq_MCF-7_Human0.97209933
131THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97189552
132AR_21909140_ChIP-Seq_LNCAP_Human0.96988151
133FOXA2_19822575_ChIP-Seq_HepG2_Human0.96730453
134MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96420075
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96153495
136MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95721209
137CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94970001
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94623100
139CHD1_26751641_Chip-Seq_LNCaP_Human0.94374015
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94293789
141GABP_19822575_ChIP-Seq_HepG2_Human0.94039063
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92895026
143GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92499146
144P68_20966046_ChIP-Seq_HELA_Human0.91730360
145NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91460220
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90766053
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88594843
148FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88209622
149* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87302364
150TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86087103
151KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84854880
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83328138
153HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.83136933
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82159290
155* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80667607
156BRD4_25478319_ChIP-Seq_HGPS_Human0.80461941
157JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.78846186
158GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77430070
159TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76081065
160* GABP_17652178_ChIP-ChIP_JURKAT_Human0.75816995
161NANOG_16153702_ChIP-ChIP_HESCs_Human0.75664567
162CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74743362
163TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.74382813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.73253373
2MP0008961_abnormal_basal_metabolism3.23972764
3MP0010352_gastrointestinal_tract_polyps3.21494876
4MP0003941_abnormal_skin_development3.03855430
5MP0003705_abnormal_hypodermis_morpholog2.94154299
6MP0008058_abnormal_DNA_repair2.93590899
7MP0002009_preneoplasia2.75770119
8MP0000569_abnormal_digit_pigmentation2.64504628
9MP0003300_gastrointestinal_ulcer2.51385641
10MP0003172_abnormal_lysosome_physiology2.21146890
11MP0005076_abnormal_cell_differentiation2.20533576
12MP0003283_abnormal_digestive_organ2.18416173
13MP0009697_abnormal_copulation2.18354188
14MP0008932_abnormal_embryonic_tissue2.03072703
15MP0008007_abnormal_cellular_replicative1.95571945
16MP0010307_abnormal_tumor_latency1.94371141
17MP0008877_abnormal_DNA_methylation1.88473494
18MP0008057_abnormal_DNA_replication1.87803533
19MP0001730_embryonic_growth_arrest1.87135057
20MP0001661_extended_life_span1.83976496
21MP0002909_abnormal_adrenal_gland1.81167610
22MP0010094_abnormal_chromosome_stability1.69181309
23MP0002877_abnormal_melanocyte_morpholog1.68013646
24MP0010678_abnormal_skin_adnexa1.66477295
25MP0003566_abnormal_cell_adhesion1.66314089
26MP0000685_abnormal_immune_system1.63842025
27MP0003077_abnormal_cell_cycle1.62218671
28MP0003303_peritoneal_inflammation1.61263345
29MP0004859_abnormal_synaptic_plasticity1.60454228
30MP0004957_abnormal_blastocyst_morpholog1.58168237
31MP0001800_abnormal_humoral_immune1.56689093
32MP0009672_abnormal_birth_weight1.56009587
33MP0000350_abnormal_cell_proliferation1.51107113
34MP0003111_abnormal_nucleus_morphology1.48222108
35MP0000604_amyloidosis1.44604969
36MP0009840_abnormal_foam_cell1.41435157
37MP0002084_abnormal_developmental_patter1.40262286
38MP0002653_abnormal_ependyma_morphology1.37084536
39MP0003091_abnormal_cell_migration1.34172763
40MP0005365_abnormal_bile_salt1.33891540
41MP0004808_abnormal_hematopoietic_stem1.33548306
42MP0004264_abnormal_extraembryonic_tissu1.33129098
43MP0008260_abnormal_autophagy1.30317814
44MP0004185_abnormal_adipocyte_glucose1.30139869
45MP0002796_impaired_skin_barrier1.29810739
46MP0005023_abnormal_wound_healing1.28851099
47MP0003221_abnormal_cardiomyocyte_apopto1.27847370
48MP0005380_embryogenesis_phenotype1.27546558
49MP0001672_abnormal_embryogenesis/_devel1.27546558
50MP0003787_abnormal_imprinting1.26774114
51MP0003121_genomic_imprinting1.25933588
52MP0002060_abnormal_skin_morphology1.25550776
53MP0003123_paternal_imprinting1.25095553
54MP0003950_abnormal_plasma_membrane1.23539885
55MP0002086_abnormal_extraembryonic_tissu1.21972489
56MP0000383_abnormal_hair_follicle1.21257906
57MP0003984_embryonic_growth_retardation1.20768996
58MP0004272_abnormal_basement_membrane1.20759806
59MP0002088_abnormal_embryonic_growth/wei1.18779445
60MP0003252_abnormal_bile_duct1.18691541
61MP0001697_abnormal_embryo_size1.17484185
62MP0003943_abnormal_hepatobiliary_system1.17260217
63MP0009703_decreased_birth_body1.17244286
64MP0002398_abnormal_bone_marrow1.17178326
65MP0000371_diluted_coat_color1.16432792
66MP0003453_abnormal_keratinocyte_physiol1.16058922
67MP0002697_abnormal_eye_size1.13404864
68MP0001790_abnormal_immune_system1.12343958
69MP0005387_immune_system_phenotype1.12343958
70MP0002085_abnormal_embryonic_tissue1.11729083
71MP0001849_ear_inflammation1.11548293
72MP0005621_abnormal_cell_physiology1.09448677
73MP0002080_prenatal_lethality1.09279212
74MP0002006_tumorigenesis1.08490575
75MP0003329_amyloid_beta_deposits1.06821727
76MP0000609_abnormal_liver_physiology1.06759383
77MP0004197_abnormal_fetal_growth/weight/1.05236251
78MP0001835_abnormal_antigen_presentation1.04180806
79MP0001915_intracranial_hemorrhage1.03910621
80MP0002139_abnormal_hepatobiliary_system1.03784645
81MP0000377_abnormal_hair_follicle1.02451799
82MP0002837_dystrophic_cardiac_calcinosis1.02150539
83MP0002396_abnormal_hematopoietic_system1.01910206
84MP0000689_abnormal_spleen_morphology1.01802222
85MP0000313_abnormal_cell_death1.01509224
86MP0003937_abnormal_limbs/digits/tail_de1.01438889
87MP0000537_abnormal_urethra_morphology1.01404662
88MP0003786_premature_aging1.01033741
89MP0000003_abnormal_adipose_tissue1.00101893
90MP0003191_abnormal_cellular_cholesterol0.99570293
91MP0010329_abnormal_lipoprotein_level0.98747314
92MP0002269_muscular_atrophy0.98294977
93MP0002254_reproductive_system_inflammat0.97916383
94MP0004858_abnormal_nervous_system0.95838002
95MP0001216_abnormal_epidermal_layer0.95069426
96MP0001873_stomach_inflammation0.94903926
97MP0003045_fibrosis0.94429524
98MP0005501_abnormal_skin_physiology0.94119114
99MP0002166_altered_tumor_susceptibility0.93922947
100MP0005310_abnormal_salivary_gland0.92870349
101MP0002452_abnormal_antigen_presenting0.91675201
102MP0000703_abnormal_thymus_morphology0.91448968
103MP0000428_abnormal_craniofacial_morphol0.91196061
104MP0005408_hypopigmentation0.90015612
105MP0005384_cellular_phenotype0.89614591
106MP0001944_abnormal_pancreas_morphology0.87560834
107MP0004510_myositis0.87090478
108MP0002722_abnormal_immune_system0.87082766
109MP0000716_abnormal_immune_system0.86139128
110MP0003763_abnormal_thymus_physiology0.85819686
111MP0003806_abnormal_nucleotide_metabolis0.85445157
112MP0000358_abnormal_cell_content/0.84670341
113MP0002092_abnormal_eye_morphology0.83951697
114MP0003868_abnormal_feces_composition0.83767326
115MP0006035_abnormal_mitochondrial_morpho0.83229326
116MP0002019_abnormal_tumor_incidence0.83159920
117MP0003115_abnormal_respiratory_system0.81987185
118MP0000627_abnormal_mammary_gland0.81920651
119MP0000733_abnormal_muscle_development0.81272496
120MP0005166_decreased_susceptibility_to0.80545897
121MP0003075_altered_response_to0.80499876
122MP0002168_other_aberrant_phenotype0.80397604
123MP0005451_abnormal_body_composition0.80070913
124MP0000432_abnormal_head_morphology0.79739835
125MP0002210_abnormal_sex_determination0.79672553
126MP0003699_abnormal_female_reproductive0.79418355
127MP0005623_abnormal_meninges_morphology0.79203612
128MP0010368_abnormal_lymphatic_system0.79141179
129MP0003656_abnormal_erythrocyte_physiolo0.78496528
130MP0000427_abnormal_hair_cycle0.77303719
131MP0005360_urolithiasis0.77040561
132MP0003828_pulmonary_edema0.76407986
133MP0005409_darkened_coat_color0.76398103
134MP0004233_abnormal_muscle_weight0.76389704
135MP0000647_abnormal_sebaceous_gland0.76322281
136MP0002925_abnormal_cardiovascular_devel0.76253563
137MP0000579_abnormal_nail_morphology0.76151346
138MP0003890_abnormal_embryonic-extraembry0.76120071
139MP0002429_abnormal_blood_cell0.75587421
140MP0003693_abnormal_embryo_hatching0.74824555
141MP0001929_abnormal_gametogenesis0.74281806
142MP0010630_abnormal_cardiac_muscle0.73003517
143MP0005395_other_phenotype0.72726538
144MP0002970_abnormal_white_adipose0.72635925
145MP0000013_abnormal_adipose_tissue0.72626791
146MP0005375_adipose_tissue_phenotype0.72422728
147MP0003183_abnormal_peptide_metabolism0.72352963
148MP0002928_abnormal_bile_duct0.72300122
149MP0002111_abnormal_tail_morphology0.69414474
150MP0001145_abnormal_male_reproductive0.66124901
151MP0001243_abnormal_dermal_layer0.66077180
152MP0003385_abnormal_body_wall0.65107587
153MP0000490_abnormal_crypts_of0.62834312

Predicted human phenotypes

RankGene SetZ-score
1Insidious onset (HP:0003587)3.94873486
2Termporal pattern (HP:0011008)3.94873486
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.88411344
4Chromsome breakage (HP:0040012)3.68071174
5Ependymoma (HP:0002888)3.58913073
6Nephroblastoma (Wilms tumor) (HP:0002667)3.40445211
7Cerebral aneurysm (HP:0004944)3.25055339
8Embryonal renal neoplasm (HP:0011794)3.19030172
9Volvulus (HP:0002580)3.18789972
10Deep philtrum (HP:0002002)3.10348054
11Abnormality of the fingertips (HP:0001211)3.07390918
12Ankyloglossia (HP:0010296)2.98525935
13Abnormality of the astrocytes (HP:0100707)2.80759096
14Astrocytoma (HP:0009592)2.80759096
15Selective tooth agenesis (HP:0001592)2.79412686
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.77224083
17Macroorchidism (HP:0000053)2.63515551
18Abnormality of chromosome stability (HP:0003220)2.62740608
19Prominent nose (HP:0000448)2.62291437
20Deep venous thrombosis (HP:0002625)2.62148088
21Progressive external ophthalmoplegia (HP:0000590)2.61553415
22Gastrointestinal stroma tumor (HP:0100723)2.59591866
23Increased nuchal translucency (HP:0010880)2.57725780
24Abnormality of oral frenula (HP:0000190)2.53206565
25Emphysema (HP:0002097)2.50519681
26Global brain atrophy (HP:0002283)2.48562197
27Abnormality of the lower motor neuron (HP:0002366)2.46411332
28Colitis (HP:0002583)2.45995021
29Osteolytic defects of the hand bones (HP:0009699)2.44083996
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.44083996
31Hyperacusis (HP:0010780)2.42985416
32Pseudobulbar signs (HP:0002200)2.41535350
33Missing ribs (HP:0000921)2.36595201
34Basal cell carcinoma (HP:0002671)2.34698997
35Resting tremor (HP:0002322)2.30670925
36Microglossia (HP:0000171)2.30183534
37Vertebral arch anomaly (HP:0008438)2.30070096
38Long toe (HP:0010511)2.27648165
39Septate vagina (HP:0001153)2.27113979
40Hematochezia (HP:0002573)2.26577852
41Shoulder girdle muscle weakness (HP:0003547)2.26305427
42Aneurysm (HP:0002617)2.24905858
43Cortical dysplasia (HP:0002539)2.21666042
44Deviation of the thumb (HP:0009603)2.19854830
45Cafe-au-lait spot (HP:0000957)2.18721996
46Heterotopia (HP:0002282)2.18158699
47Subacute progressive viral hepatitis (HP:0006572)2.17419827
48Striae distensae (HP:0001065)2.15707851
49Neoplasm of the heart (HP:0100544)2.15402018
50Recurrent bronchitis (HP:0002837)2.13794956
51Sandal gap (HP:0001852)2.13751734
52Enlarged penis (HP:0000040)2.12874720
53Upper limb amyotrophy (HP:0009129)2.12740450
54Distal upper limb amyotrophy (HP:0007149)2.12740450
55Back pain (HP:0003418)2.11516762
56Neoplasm of striated muscle (HP:0009728)2.09147302
57Proximal placement of thumb (HP:0009623)2.08121820
58Hand muscle atrophy (HP:0009130)2.08074720
59Neoplasm of the oral cavity (HP:0100649)2.07408155
60Abnormality of the preputium (HP:0100587)2.06565188
61Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05952284
62Short 4th metacarpal (HP:0010044)2.05952284
63Deep palmar crease (HP:0006191)2.04672180
64Skull defect (HP:0001362)2.04477980
65Aortic aneurysm (HP:0004942)2.01955819
66Ankle contracture (HP:0006466)2.01422058
67Narrow palate (HP:0000189)1.99932782
68Dysmetric saccades (HP:0000641)1.99549210
69Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98803855
70Short 1st metacarpal (HP:0010034)1.98803855
71Shallow orbits (HP:0000586)1.98352453
72Ulnar bowing (HP:0003031)1.97862719
73Malignant gastrointestinal tract tumors (HP:0006749)1.96795208
74Gastrointestinal carcinoma (HP:0002672)1.96795208
75Urethral obstruction (HP:0000796)1.96576799
76Leiomyosarcoma (HP:0100243)1.94700350
77Uterine leiomyosarcoma (HP:0002891)1.94700350
78Wide nose (HP:0000445)1.94558357
79Gastrointestinal inflammation (HP:0004386)1.93496230
80Genu recurvatum (HP:0002816)1.93340899
81Hemiplegia (HP:0002301)1.92561231
82Microvesicular hepatic steatosis (HP:0001414)1.91489325
83Abnormal lung lobation (HP:0002101)1.91214746
84Asymmetry of the thorax (HP:0001555)1.91001455
85Overlapping toe (HP:0001845)1.90793556
86Myelodysplasia (HP:0002863)1.90010456
87Bowel diverticulosis (HP:0005222)1.89877902
88Long eyelashes (HP:0000527)1.88462887
89Large hands (HP:0001176)1.88182948
90Relative macrocephaly (HP:0004482)1.86753725
91Acute myeloid leukemia (HP:0004808)1.86423421
92Embryonal neoplasm (HP:0002898)1.86360926
93Urinary glycosaminoglycan excretion (HP:0003541)1.85550055
94Mucopolysacchariduria (HP:0008155)1.85550055
95Curly hair (HP:0002212)1.84815741
96Mitral valve prolapse (HP:0001634)1.84700324
97Protrusio acetabuli (HP:0003179)1.84688909
98Limb hypertonia (HP:0002509)1.84467841
99Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.84061826
100Pelvic girdle muscle weakness (HP:0003749)1.83964781
101Thyroid carcinoma (HP:0002890)1.83235300
102Medulloblastoma (HP:0002885)1.82956665
103Myocardial infarction (HP:0001658)1.82457227
104Short phalanx of the thumb (HP:0009660)1.82023096
105Short nail (HP:0001799)1.81513719
106Syringomyelia (HP:0003396)1.81280795
107Spinal cord lesions (HP:0100561)1.81280795
108Abnormality of the pancreatic islet cells (HP:0006476)1.80995260
109Abnormality of endocrine pancreas physiology (HP:0012093)1.80995260
110Micronodular cirrhosis (HP:0001413)1.80463212
111Spinal muscular atrophy (HP:0007269)1.80023691
112Breast carcinoma (HP:0003002)1.80011856
113Aplasia/Hypoplasia of the sternum (HP:0006714)1.79654872
114Spondylolisthesis (HP:0003302)1.79433302
115Cutaneous melanoma (HP:0012056)1.78989712
116Gonadotropin excess (HP:0000837)1.78876708
11711 pairs of ribs (HP:0000878)1.78855977
118High pitched voice (HP:0001620)1.78841815
119Lymphangioma (HP:0100764)1.78040856
120Horizontal nystagmus (HP:0000666)1.77645753
121Glioma (HP:0009733)1.77127940
122Autoamputation (HP:0001218)1.76017618
123Broad thumb (HP:0011304)1.75971862
124Truncal obesity (HP:0001956)1.75748364
125Papilloma (HP:0012740)1.75741451
126Verrucae (HP:0200043)1.75741451
127Abnormality of the 4th metacarpal (HP:0010012)1.75425378
128Abnormality of mucopolysaccharide metabolism (HP:0011020)1.75396732
129Abnormality of polysaccharide metabolism (HP:0011012)1.75396732
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.75396732
131Cervical subluxation (HP:0003308)1.74856483
132Urinary bladder sphincter dysfunction (HP:0002839)1.74556835
133Entropion (HP:0000621)1.74461896
134Spastic diplegia (HP:0001264)1.74144649
135Ectopic kidney (HP:0000086)1.73830607
136Papillary thyroid carcinoma (HP:0002895)1.73825809
137Tetraparesis (HP:0002273)1.73671899
138Abnormal foot bone ossification (HP:0010675)1.73560104
139Meckel diverticulum (HP:0002245)1.73401497
140Abnormality of the ileum (HP:0001549)1.72733912
141Inflammation of the large intestine (HP:0002037)1.71979323
142Abnormality of ocular smooth pursuit (HP:0000617)1.71946962
143Right ventricular cardiomyopathy (HP:0011663)1.71937216
144Abnormality of the umbilical cord (HP:0010881)1.70231065
145IgM deficiency (HP:0002850)1.69750631
146Impaired smooth pursuit (HP:0007772)1.69581084
147Restrictive lung disease (HP:0002091)1.69160394
148Bladder neoplasm (HP:0009725)1.68314592
149Bladder carcinoma (HP:0002862)1.68314592
150Transitional cell carcinoma of the bladder (HP:0006740)1.67909057
151Fibroma (HP:0010614)1.67899781
152Low anterior hairline (HP:0000294)1.65553663
153Rhabdomyosarcoma (HP:0002859)1.65190757
154EMG: neuropathic changes (HP:0003445)1.64900430
155Duodenal stenosis (HP:0100867)1.64900389
156Small intestinal stenosis (HP:0012848)1.64900389
157Skin tags (HP:0010609)1.64296764
158Advanced eruption of teeth (HP:0006288)1.64165591
159Absent frontal sinuses (HP:0002688)1.64126131
160Hypopigmentation of the fundus (HP:0007894)1.63824856
161Vertebral clefting (HP:0008428)1.63614807
162Pointed chin (HP:0000307)1.62802392
163Lower limb hyperreflexia (HP:0002395)1.62241817
164Upper motor neuron abnormality (HP:0002127)1.62226137
165Lymphopenia (HP:0001888)1.62054162
166Clitoromegaly (HP:0000057)1.61470632
167Aplasia cutis congenita (HP:0001057)1.61301264
168Abnormality of the salivary glands (HP:0010286)1.61179868
169Abnormality of chromosome segregation (HP:0002916)1.60406891
170Cystic hygroma (HP:0000476)1.58336724
171Aplasia/Hypoplasia of the uvula (HP:0010293)1.57656177
172Capillary hemangiomas (HP:0005306)1.57573036
173Facial cleft (HP:0002006)1.57243422
174Facial hemangioma (HP:0000329)1.56958439
175Intrahepatic cholestasis (HP:0001406)1.56369256
176Lip pit (HP:0100267)1.55550843
177Uterine neoplasm (HP:0010784)1.55435956
178Metaphyseal cupping (HP:0003021)1.55253387

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.12185913
2PNCK3.03595338
3ERN13.01659618
4EEF2K2.81412082
5BRSK22.77151234
6PBK2.73295693
7TRIB32.68811435
8MAP4K12.65563884
9MET2.49959698
10PKN22.45153473
11MAP3K92.44080787
12SCYL22.38161794
13WEE12.20800866
14SRPK12.11107958
15SIK12.03670150
16EIF2AK31.98155116
17MAP3K131.91682301
18SMG11.91259979
19KSR21.90707407
20BUB11.88960171
21KSR11.86871631
22STK101.86262713
23EIF2AK11.83706720
24MAP3K101.79748351
25CDK61.74457825
26CAMK1D1.70144211
27PRKD31.69774210
28MST1R1.61740994
29CDC71.59142613
30GRK61.53209643
31BRD41.53078938
32PLK41.51360107
33AKT31.48477379
34MTOR1.42298575
35SIK21.40608480
36LRRK21.35300581
37TAF11.30506419
38JAK11.29087237
39ICK1.29071310
40BRSK11.28924258
41ALK1.28870805
42CAMK1G1.27525691
43YES11.22504869
44PDGFRA1.19629526
45PASK1.19152346
46TYRO31.19137844
47PLK11.16291920
48MKNK11.14575828
49TAOK31.13805831
50PTK61.13145778
51CDK71.13016857
52CSF1R1.11111118
53NEK61.10480415
54PLK31.08764860
55FGFR41.05624089
56PRPF4B1.02737578
57NEK90.98789984
58NEK20.97800845
59SIK30.97765559
60LATS10.95931680
61TTN0.95251144
62STK40.92061434
63AURKB0.91998371
64MELK0.90843245
65FGR0.90220104
66TAOK10.89905385
67FRK0.89516998
68STK30.88985525
69RAF10.88025346
70ATM0.87198640
71RET0.87175258
72DYRK30.85399530
73PRKCH0.83666129
74FGFR20.82659548
75RIPK40.80066799
76MAP3K80.79028395
77SGK30.77952127
78TSSK60.77764445
79MAP3K60.77366038
80CDC42BPA0.76680833
81MARK30.76328780
82HIPK20.75685256
83FLT30.75296113
84RIPK10.74789484
85TYK20.73695410
86MKNK20.73123642
87ERBB40.72427347
88JAK20.72051022
89CDK40.70774040
90LATS20.69612517
91MAP3K40.66626368
92FGFR30.66571697
93MAPKAPK30.65874378
94JAK30.65633646
95PDK20.64641416
96CHEK10.64123485
97MATK0.63816635
98PAK60.63753203
99EIF2AK20.62965995
100DAPK10.61069111
101TTK0.60441281
102MAP3K20.59390458
103STK110.58511284
104ARAF0.58303359
105PRKD20.57918405
106CDK10.57754536
107RPS6KB10.57587450
108BMX0.56829644
109NLK0.56078153
110CDK90.53758439
111ATR0.53691671
112NEK10.53409211
113AKT20.52912906
114DAPK20.52739219
115CSK0.52349098
116TGFBR20.52255616
117PDGFRB0.51279660
118CDK20.51207817
119MAP3K70.50536042
120PIM10.50344988
121BRAF0.50279505
122CDK190.49185487
123CLK10.46646740
124PDK10.46405017
125ZAK0.46375889
126RPS6KB20.45417894
127MARK20.45250082
128FER0.45044186
129DMPK0.44853088
130CHEK20.44738777
131PAK40.44610406
132STK390.44474681
133EPHA20.44256121
134RPS6KA40.44181834
135KIT0.44021429
136CSNK1D0.42974920
137FGFR10.42073384
138MAP3K10.41512165
139MAP3K140.41041200
140MAPK100.40928696
141EPHB10.40147749
142PAK20.39773604
143DYRK1B0.39501225
144MST40.38638973
145CAMKK10.37780489
146CHUK0.37649142
147PTK20.37343277
148MAPK110.36977044
149HCK0.36680773
150EGFR0.35892059
151NUAK10.35532970
152TRPM70.35243445

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.27792122
2Mismatch repair_Homo sapiens_hsa034303.06518845
3Nitrogen metabolism_Homo sapiens_hsa009102.97109798
4Non-homologous end-joining_Homo sapiens_hsa034502.89704519
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.57583236
6B cell receptor signaling pathway_Homo sapiens_hsa046622.53077521
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.14706650
8Nucleotide excision repair_Homo sapiens_hsa034201.95428405
9Lysine degradation_Homo sapiens_hsa003101.86407029
10mTOR signaling pathway_Homo sapiens_hsa041501.85321617
11Dorso-ventral axis formation_Homo sapiens_hsa043201.74324634
12Spliceosome_Homo sapiens_hsa030401.74196832
13Base excision repair_Homo sapiens_hsa034101.58250440
14Fanconi anemia pathway_Homo sapiens_hsa034601.52371083
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48089733
16Non-small cell lung cancer_Homo sapiens_hsa052231.43517500
17Insulin resistance_Homo sapiens_hsa049311.39409448
18Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38070113
19Type II diabetes mellitus_Homo sapiens_hsa049301.37611902
20Notch signaling pathway_Homo sapiens_hsa043301.35038334
21Prostate cancer_Homo sapiens_hsa052151.33155520
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29660242
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28243797
24Homologous recombination_Homo sapiens_hsa034401.27493441
25Chronic myeloid leukemia_Homo sapiens_hsa052201.25955939
26Glioma_Homo sapiens_hsa052141.17154210
27Neurotrophin signaling pathway_Homo sapiens_hsa047221.15723798
28Glucagon signaling pathway_Homo sapiens_hsa049221.15306240
29Arginine biosynthesis_Homo sapiens_hsa002201.15008196
30p53 signaling pathway_Homo sapiens_hsa041151.14970922
31Basal transcription factors_Homo sapiens_hsa030221.12272887
32Estrogen signaling pathway_Homo sapiens_hsa049151.11681260
33N-Glycan biosynthesis_Homo sapiens_hsa005101.11665797
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10549682
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10345510
36RNA degradation_Homo sapiens_hsa030181.10221561
37Oocyte meiosis_Homo sapiens_hsa041141.09193289
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06880012
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05563526
40Long-term potentiation_Homo sapiens_hsa047201.04224681
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03488562
42Selenocompound metabolism_Homo sapiens_hsa004501.00706348
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.99117680
44Adherens junction_Homo sapiens_hsa045200.98712498
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.97138439
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96826631
47Pancreatic cancer_Homo sapiens_hsa052120.95449382
48Primary immunodeficiency_Homo sapiens_hsa053400.95193264
49Biosynthesis of amino acids_Homo sapiens_hsa012300.94688282
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94476161
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93637149
52Insulin signaling pathway_Homo sapiens_hsa049100.93211709
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92826448
54Carbon metabolism_Homo sapiens_hsa012000.91335602
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91030691
56Endometrial cancer_Homo sapiens_hsa052130.89513578
57Insulin secretion_Homo sapiens_hsa049110.89456653
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89425815
59MicroRNAs in cancer_Homo sapiens_hsa052060.89007757
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87797521
61Antigen processing and presentation_Homo sapiens_hsa046120.87504540
62RNA transport_Homo sapiens_hsa030130.87403981
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87368610
64Colorectal cancer_Homo sapiens_hsa052100.86717407
65Proteoglycans in cancer_Homo sapiens_hsa052050.85715173
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85126090
67Bile secretion_Homo sapiens_hsa049760.84096375
68Inositol phosphate metabolism_Homo sapiens_hsa005620.83477173
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83334247
70VEGF signaling pathway_Homo sapiens_hsa043700.82017881
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.81714292
72Steroid biosynthesis_Homo sapiens_hsa001000.81694796
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.79106079
74AMPK signaling pathway_Homo sapiens_hsa041520.76606600
75Cell cycle_Homo sapiens_hsa041100.76522119
76mRNA surveillance pathway_Homo sapiens_hsa030150.76373752
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76283706
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.76082464
79Vitamin B6 metabolism_Homo sapiens_hsa007500.75428652
80Thyroid cancer_Homo sapiens_hsa052160.74301145
81Renal cell carcinoma_Homo sapiens_hsa052110.74252416
82One carbon pool by folate_Homo sapiens_hsa006700.73777199
83HTLV-I infection_Homo sapiens_hsa051660.73408446
84Fatty acid metabolism_Homo sapiens_hsa012120.71992229
85Complement and coagulation cascades_Homo sapiens_hsa046100.70776746
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70541704
87Propanoate metabolism_Homo sapiens_hsa006400.69396543
88Choline metabolism in cancer_Homo sapiens_hsa052310.68376964
89Focal adhesion_Homo sapiens_hsa045100.68147050
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.67718933
91Acute myeloid leukemia_Homo sapiens_hsa052210.67545167
92GnRH signaling pathway_Homo sapiens_hsa049120.66952899
93Lysosome_Homo sapiens_hsa041420.66910890
94Sphingolipid metabolism_Homo sapiens_hsa006000.66697376
95Pyruvate metabolism_Homo sapiens_hsa006200.66298430
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65890113
97Alcoholism_Homo sapiens_hsa050340.65294496
98TGF-beta signaling pathway_Homo sapiens_hsa043500.65240574
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64950144
100Small cell lung cancer_Homo sapiens_hsa052220.63811591
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63469154
102Systemic lupus erythematosus_Homo sapiens_hsa053220.63064562
103Cocaine addiction_Homo sapiens_hsa050300.62988208
104Gap junction_Homo sapiens_hsa045400.61500406
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60965902
106Pentose phosphate pathway_Homo sapiens_hsa000300.60871951
107Fatty acid degradation_Homo sapiens_hsa000710.60349596
108T cell receptor signaling pathway_Homo sapiens_hsa046600.60115010
109ABC transporters_Homo sapiens_hsa020100.59354952
110Bladder cancer_Homo sapiens_hsa052190.59049740
111Viral carcinogenesis_Homo sapiens_hsa052030.58593627
112Hippo signaling pathway_Homo sapiens_hsa043900.57454866
113Amphetamine addiction_Homo sapiens_hsa050310.56983100
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55656809
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.55608470
116Caffeine metabolism_Homo sapiens_hsa002320.55342880
117Prolactin signaling pathway_Homo sapiens_hsa049170.55182634
118FoxO signaling pathway_Homo sapiens_hsa040680.55179489
119Hepatitis B_Homo sapiens_hsa051610.54688997
120Fatty acid biosynthesis_Homo sapiens_hsa000610.54139534
121Tryptophan metabolism_Homo sapiens_hsa003800.53918898
122Prion diseases_Homo sapiens_hsa050200.53656165
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53164962
124Osteoclast differentiation_Homo sapiens_hsa043800.52880488
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52746431
126Folate biosynthesis_Homo sapiens_hsa007900.51909966
127Shigellosis_Homo sapiens_hsa051310.51526896
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51445926
129cAMP signaling pathway_Homo sapiens_hsa040240.50954226
130ErbB signaling pathway_Homo sapiens_hsa040120.50655525
131Apoptosis_Homo sapiens_hsa042100.50381354
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49881759
133Gastric acid secretion_Homo sapiens_hsa049710.49811184
134Pyrimidine metabolism_Homo sapiens_hsa002400.49037914
135Measles_Homo sapiens_hsa051620.47484184
136Pathways in cancer_Homo sapiens_hsa052000.47269104
137Melanoma_Homo sapiens_hsa052180.46859732
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45876218
139Wnt signaling pathway_Homo sapiens_hsa043100.45276874
140Tight junction_Homo sapiens_hsa045300.45267243
141Other glycan degradation_Homo sapiens_hsa005110.42517396
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42153530
143Hepatitis C_Homo sapiens_hsa051600.41153989
144Leukocyte transendothelial migration_Homo sapiens_hsa046700.38192498

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