PIK3R5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.19932347
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.19932347
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.19932347
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.19932347
5modulation by symbiont of host immune response (GO:0052553)6.19932347
6positive regulation by symbiont of host defense response (GO:0052509)6.19932347
7positive regulation of gamma-delta T cell activation (GO:0046645)5.30983905
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04091243
9response to peptidoglycan (GO:0032494)4.89103577
10neutrophil activation involved in immune response (GO:0002283)4.78941317
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.47056564
12negative regulation of cell killing (GO:0031342)4.47056564
13macrophage activation involved in immune response (GO:0002281)4.45376978
14positive regulation of interferon-alpha production (GO:0032727)4.35754911
15regulation of interferon-beta biosynthetic process (GO:0045357)4.27871545
16response to host immune response (GO:0052572)4.26187371
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.26187371
18response to muramyl dipeptide (GO:0032495)4.22200129
19detection of other organism (GO:0098543)4.18924385
20regulation of interferon-alpha production (GO:0032647)4.17176979
21immunoglobulin mediated immune response (GO:0016064)4.09455521
22cellular extravasation (GO:0045123)4.06357403
23detection of bacterium (GO:0016045)3.94186959
24granulocyte activation (GO:0036230)3.91357536
25neutrophil activation (GO:0042119)3.91062301
26NIK/NF-kappaB signaling (GO:0038061)3.86670092
27response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86317699
28response to host (GO:0075136)3.86317699
29response to host defenses (GO:0052200)3.86317699
30positive regulation of antigen processing and presentation (GO:0002579)3.82222518
31antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.80345184
32antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.80345184
33respiratory burst (GO:0045730)3.74056596
34regulation of B cell receptor signaling pathway (GO:0050855)3.67897455
35antigen processing and presentation of endogenous antigen (GO:0019883)3.66575923
36leukocyte aggregation (GO:0070486)3.65891107
37detection of external biotic stimulus (GO:0098581)3.65152003
38regulation of gamma-delta T cell activation (GO:0046643)3.64828219
39response to type I interferon (GO:0034340)3.64809307
40type I interferon signaling pathway (GO:0060337)3.64411016
41cellular response to type I interferon (GO:0071357)3.64411016
42microglial cell activation (GO:0001774)3.60584136
43positive regulation of cellular amide metabolic process (GO:0034250)3.60082602
44natural killer cell mediated cytotoxicity (GO:0042267)3.59354464
45natural killer cell mediated immunity (GO:0002228)3.59354464
46lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55190527
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.55046093
48negative regulation of interleukin-12 production (GO:0032695)3.54247455
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.50907572
50negative regulation of T cell mediated immunity (GO:0002710)3.49716087
51myeloid cell activation involved in immune response (GO:0002275)3.48737867
52regulation of T cell tolerance induction (GO:0002664)3.46256719
53T cell migration (GO:0072678)3.45594483
54interferon-gamma-mediated signaling pathway (GO:0060333)3.44370587
55positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.44259865
56modulation by symbiont of host cellular process (GO:0044068)3.41906464
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.41741762
58positive regulation of heat generation (GO:0031652)3.40864860
59germinal center formation (GO:0002467)3.38985182
60positive regulation of interferon-beta production (GO:0032728)3.35320119
61I-kappaB phosphorylation (GO:0007252)3.33692782
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33374393
63negative regulation of erythrocyte differentiation (GO:0045647)3.30554830
64positive regulation of chemokine biosynthetic process (GO:0045080)3.29033141
65detection of biotic stimulus (GO:0009595)3.27882952
66negative regulation of cytokine production involved in immune response (GO:0002719)3.27430533
67regulation of tolerance induction (GO:0002643)3.27188960
68regulation of gamma-delta T cell differentiation (GO:0045586)3.25724549
69regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24975018
70regulation of antigen processing and presentation (GO:0002577)3.23736387
71negative regulation of leukocyte mediated immunity (GO:0002704)3.18295098
72positive regulation of interleukin-12 production (GO:0032735)3.17499150
73tolerance induction (GO:0002507)3.16355281
74neutrophil mediated immunity (GO:0002446)3.16326592
75regulation of mast cell activation involved in immune response (GO:0033006)3.16216192
76macrophage activation (GO:0042116)3.14532028
77positive regulation of B cell differentiation (GO:0045579)3.14125415
78defense response to protozoan (GO:0042832)3.13847205
79leukocyte cell-cell adhesion (GO:0007159)3.13722493
80detection of molecule of bacterial origin (GO:0032490)3.13508779
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11992761
82regulation of mast cell activation (GO:0033003)3.11310432
83myeloid dendritic cell differentiation (GO:0043011)3.06584134
84myeloid dendritic cell activation (GO:0001773)3.05390145
85positive regulation of humoral immune response (GO:0002922)3.04582554
86regulation of leukocyte degranulation (GO:0043300)3.03871877
87B cell mediated immunity (GO:0019724)3.03652541
88negative regulation of interleukin-17 production (GO:0032700)3.03294123
89positive thymic T cell selection (GO:0045059)3.03278373
90response to interleukin-15 (GO:0070672)3.03208613
91positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02371788
92regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00125667
93T-helper 1 type immune response (GO:0042088)2.95680603
94positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.94533013
95regulation of fever generation (GO:0031620)2.94392065
96negative thymic T cell selection (GO:0045060)2.94266992
97hydrogen peroxide biosynthetic process (GO:0050665)2.94155324
98regulation of T-helper 2 cell differentiation (GO:0045628)2.94055523
99regulation of interleukin-12 production (GO:0032655)2.93962609
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.93626516
101positive regulation of mast cell degranulation (GO:0043306)2.93626516
102positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93565410
103regulation of T-helper 1 cell differentiation (GO:0045625)2.91558962
104regulation of alpha-beta T cell proliferation (GO:0046640)2.91029588
105negative T cell selection (GO:0043383)2.91005750
106superoxide anion generation (GO:0042554)2.88429636
107regulation of interleukin-2 biosynthetic process (GO:0045076)2.87599594
108positive regulation of mast cell activation (GO:0033005)2.87461928
109cytokine secretion (GO:0050663)2.87421095
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.85696728
111myeloid leukocyte activation (GO:0002274)2.85531030
112regulation of mast cell degranulation (GO:0043304)2.85262181
113positive regulation of type 2 immune response (GO:0002830)2.84920630
114leukocyte mediated cytotoxicity (GO:0001909)2.83397428
115interferon-gamma production (GO:0032609)2.83243372
116production of molecular mediator involved in inflammatory response (GO:0002532)2.82155319
117regulation of B cell differentiation (GO:0045577)2.81167197
118B cell receptor signaling pathway (GO:0050853)2.80447127
119negative regulation of interleukin-6 production (GO:0032715)2.79987494
120negative regulation of viral genome replication (GO:0045071)2.79663666
121cellular response to virus (GO:0098586)2.78637634
122negative regulation of innate immune response (GO:0045824)2.78566458
123positive regulation of tolerance induction (GO:0002645)2.78112644
124monocyte chemotaxis (GO:0002548)2.77525608
125regulation of mononuclear cell migration (GO:0071675)2.77394356
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77351760
127regulation of interleukin-17 production (GO:0032660)2.77074895
128response to protozoan (GO:0001562)2.76974188
129positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.75734264
130regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.74333210
131positive regulation of alpha-beta T cell proliferation (GO:0046641)2.73586719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.67039969
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.46277010
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.04687245
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.56785100
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.44231176
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.33791871
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.18088025
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.15633789
9* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.08548040
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.59174625
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52277682
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.42952223
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.23805307
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.20077633
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.95140244
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76720778
17* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.67839586
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66925801
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45481856
20* RUNX_20019798_ChIP-Seq_JUKART_Human2.26295481
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20287756
22* SPI1_23547873_ChIP-Seq_NB4_Human2.19568520
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15423791
24SCL_19346495_ChIP-Seq_HPC-7_Human2.11502097
25* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.09891757
26MYB_26560356_Chip-Seq_TH2_Human2.07385191
27SPI1_23127762_ChIP-Seq_K562_Human2.04474629
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.01512798
29* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.99055262
30VDR_24763502_ChIP-Seq_THP-1_Human1.95577168
31MAF_26560356_Chip-Seq_TH1_Human1.90751677
32VDR_24787735_ChIP-Seq_THP-1_Human1.86676718
33MYB_26560356_Chip-Seq_TH1_Human1.84322402
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81849929
35VDR_21846776_ChIP-Seq_THP-1_Human1.79735110
36* PU_27001747_Chip-Seq_BMDM_Mouse1.79322647
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.76938881
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74395038
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71337246
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.63552624
41* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61489266
42* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55633351
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54298907
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50065845
45* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45475134
46UTX_26944678_Chip-Seq_JUKART_Human1.44685751
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43180847
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42870537
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38175972
50* GATA3_27048872_Chip-Seq_THYMUS_Human1.37534998
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37525702
52* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36637553
53TCF7_22412390_ChIP-Seq_EML_Mouse1.34148474
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33676671
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.29936925
56GATA3_26560356_Chip-Seq_TH2_Human1.27853642
57GATA1_22025678_ChIP-Seq_K562_Human1.23539020
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21496168
59MYC_22102868_ChIP-Seq_BL_Human1.21061815
60LXR_22292898_ChIP-Seq_THP-1_Human1.18503346
61* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18463744
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17736933
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17123837
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15613505
65* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08138194
66MAF_26560356_Chip-Seq_TH2_Human1.07642379
67* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06728500
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04590490
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03900026
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02001863
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99875391
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98504322
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96438140
74ELK3_25401928_ChIP-Seq_HUVEC_Human0.94215665
75GATA1_19941827_ChIP-Seq_MEL_Mouse0.94184579
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91624194
77BCL6_27268052_Chip-Seq_Bcells_Human0.91611137
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89979864
79KDM2B_26808549_Chip-Seq_DND41_Human0.88511944
80NCOR1_26117541_ChIP-Seq_K562_Human0.88127479
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87974663
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87282280
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87276325
84BCOR_27268052_Chip-Seq_Bcells_Human0.87148591
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85936297
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80780231
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80139926
88* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79598807
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79511659
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79400101
91NOTCH1_21737748_ChIP-Seq_TLL_Human0.77954655
92TFEB_21752829_ChIP-Seq_HELA_Human0.77785418
93GATA2_19941826_ChIP-Seq_K562_Human0.75946915
94GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75652041
95TP63_17297297_ChIP-ChIP_HaCaT_Human0.73838365
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73523811
97SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73492970
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.72361262
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.70680150
100SMRT_27268052_Chip-Seq_Bcells_Human0.69689403
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.66993823
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.65308838
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64078087
104GATA1_19941826_ChIP-Seq_K562_Human0.63721188
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.62134306
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.62134306
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.60426200
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.59878954
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58852431
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58112517
111* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.56519218
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56299509
113SPI1_20517297_ChIP-Seq_HL60_Human0.56276312
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.55525447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.31986653
2MP0003436_decreased_susceptibility_to3.57179562
3MP0009785_altered_susceptibility_to3.44810930
4MP0003303_peritoneal_inflammation3.32673041
5MP0001790_abnormal_immune_system3.22083600
6MP0005387_immune_system_phenotype3.22083600
7MP0000685_abnormal_immune_system3.13725210
8MP0005000_abnormal_immune_tolerance3.12885366
9MP0000569_abnormal_digit_pigmentation3.08542738
10MP0002148_abnormal_hypersensitivity_rea3.07735018
11* MP0002419_abnormal_innate_immunity3.06122517
12MP0005671_abnormal_response_to3.03268731
13MP0006082_CNS_inflammation3.01727381
14MP0005025_abnormal_response_to2.88140361
15MP0001800_abnormal_humoral_immune2.83033174
16MP0002452_abnormal_antigen_presenting2.78427411
17MP0004510_myositis2.74785185
18MP0005058_abnormal_lysosome_morphology2.70354812
19MP0002723_abnormal_immune_serum2.69339772
20MP0003172_abnormal_lysosome_physiology2.45932338
21MP0003724_increased_susceptibility_to2.45002327
22* MP0001819_abnormal_immune_cell2.43518386
23* MP0002420_abnormal_adaptive_immunity2.40677062
24MP0009278_abnormal_bone_marrow2.27608867
25MP0004947_skin_inflammation2.20265862
26MP0005464_abnormal_platelet_physiology2.12607558
27MP0002405_respiratory_system_inflammati2.09454638
28MP0001533_abnormal_skeleton_physiology1.92994384
29MP0002398_abnormal_bone_marrow1.85020092
30MP0000716_abnormal_immune_system1.84860729
31MP0001845_abnormal_inflammatory_respons1.83432728
32MP0003448_altered_tumor_morphology1.78107958
33MP0003763_abnormal_thymus_physiology1.78015829
34MP0005451_abnormal_body_composition1.77431580
35MP0002006_tumorigenesis1.77278431
36MP0002166_altered_tumor_susceptibility1.71009966
37MP0010155_abnormal_intestine_physiology1.70305208
38MP0003300_gastrointestinal_ulcer1.68517739
39MP0001545_abnormal_hematopoietic_system1.63931055
40MP0005397_hematopoietic_system_phenotyp1.63931055
41MP0001853_heart_inflammation1.61654757
42MP0009333_abnormal_splenocyte_physiolog1.60070689
43MP0005310_abnormal_salivary_gland1.59380604
44MP0005174_abnormal_tail_pigmentation1.58087372
45MP0008469_abnormal_protein_level1.54552329
46MP0000689_abnormal_spleen_morphology1.53942081
47MP0003183_abnormal_peptide_metabolism1.52782572
48MP0002998_abnormal_bone_remodeling1.50344012
49MP0009764_decreased_sensitivity_to1.48609309
50MP0002429_abnormal_blood_cell1.45814232
51MP0002722_abnormal_immune_system1.44067256
52MP0000858_altered_metastatic_potential1.40485309
53MP0008004_abnormal_stomach_pH1.40428137
54MP0005257_abnormal_intraocular_pressure1.32741644
55MP0000015_abnormal_ear_pigmentation1.26745802
56MP0002277_abnormal_respiratory_mucosa1.26463350
57MP0000343_altered_response_to1.22876969
58MP0005076_abnormal_cell_differentiation1.21982804
59MP0003075_altered_response_to1.19110403
60MP0002396_abnormal_hematopoietic_system1.18744000
61MP0001873_stomach_inflammation1.15677238
62MP0002933_joint_inflammation1.15570405
63MP0010307_abnormal_tumor_latency1.15557226
64MP0003191_abnormal_cellular_cholesterol1.14589923
65MP0009840_abnormal_foam_cell1.13966498
66MP0000703_abnormal_thymus_morphology1.09360157
67MP0001851_eye_inflammation1.06150250
68MP0000604_amyloidosis1.04884306
69MP0004883_abnormal_blood_vessel1.04455699
70MP0004808_abnormal_hematopoietic_stem1.03137912
71MP0005166_decreased_susceptibility_to0.96681860
72MP0000371_diluted_coat_color0.95963268
73MP0008260_abnormal_autophagy0.92116895
74MP0002132_abnormal_respiratory_system0.91934239
75MP0003566_abnormal_cell_adhesion0.90260023
76MP0002138_abnormal_hepatobiliary_system0.89639834
77MP0005390_skeleton_phenotype0.89554811
78MP0003828_pulmonary_edema0.89044497
79MP0009763_increased_sensitivity_to0.88452040
80MP0002254_reproductive_system_inflammat0.86560419
81MP0003806_abnormal_nucleotide_metabolis0.85110354
82MP0003091_abnormal_cell_migration0.83506321
83MP0002332_abnormal_exercise_endurance0.83410599
84MP0006054_spinal_hemorrhage0.82041874
85MP0004381_abnormal_hair_follicle0.80735423
86MP0009765_abnormal_xenobiotic_induced0.76943573
87MP0000490_abnormal_crypts_of0.76765494
88MP0005167_abnormal_blood-brain_barrier0.76565679
89MP0003866_abnormal_defecation0.76269789
90MP0003453_abnormal_keratinocyte_physiol0.75163526
91MP0000465_gastrointestinal_hemorrhage0.73703891
92MP0003690_abnormal_glial_cell0.71688358
93MP0000920_abnormal_myelination0.71443212
94MP0002139_abnormal_hepatobiliary_system0.68608764
95MP0003795_abnormal_bone_structure0.67536788
96MP0008874_decreased_physiological_sensi0.64288589
97MP0004782_abnormal_surfactant_physiolog0.64019454
98MP0004858_abnormal_nervous_system0.63952438
99MP0000249_abnormal_blood_vessel0.63741296
100MP0003045_fibrosis0.60005743
101MP0003221_abnormal_cardiomyocyte_apopto0.56783677
102MP0005164_abnormal_response_to0.56594998
103MP0000767_abnormal_smooth_muscle0.55398813
104MP0002136_abnormal_kidney_physiology0.53255004
105MP0001958_emphysema0.52840453
106MP0002019_abnormal_tumor_incidence0.52380364
107MP0003329_amyloid_beta_deposits0.51866432
108MP0003656_abnormal_erythrocyte_physiolo0.51852446
109MP0005023_abnormal_wound_healing0.51795000
110MP0002163_abnormal_gland_morphology0.50997866
111MP0000609_abnormal_liver_physiology0.49765375
112MP0002693_abnormal_pancreas_physiology0.48478245
113MP0010352_gastrointestinal_tract_polyps0.48197118
114MP0005319_abnormal_enzyme/_coenzyme0.47118419
115MP0005621_abnormal_cell_physiology0.46201944
116MP0001663_abnormal_digestive_system0.45859169
117MP0005535_abnormal_body_temperature0.45482096

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.86430175
2Recurrent bacterial skin infections (HP:0005406)6.18480265
3Eczematoid dermatitis (HP:0000976)6.14122172
4Elevated erythrocyte sedimentation rate (HP:0003565)5.30404752
5Recurrent gram-negative bacterial infections (HP:0005420)4.89156314
6Mediastinal lymphadenopathy (HP:0100721)4.79913368
7Abnormality of macrophages (HP:0004311)4.75455143
8Stomatitis (HP:0010280)4.71995879
9Myositis (HP:0100614)4.63621134
10Optic neuritis (HP:0100653)4.47793787
11Retrobulbar optic neuritis (HP:0100654)4.47793787
12Orchitis (HP:0100796)4.41095590
13Autoimmune thrombocytopenia (HP:0001973)4.25852311
14Recurrent fungal infections (HP:0002841)4.21765978
15Recurrent skin infections (HP:0001581)3.97890649
16Gingivitis (HP:0000230)3.93438318
17Increased cerebral lipofuscin (HP:0011813)3.83099824
18Vasculitis (HP:0002633)3.75737222
19Recurrent viral infections (HP:0004429)3.75603368
20Vacuolated lymphocytes (HP:0001922)3.74052224
21Chronic obstructive pulmonary disease (HP:0006510)3.51854871
22Obstructive lung disease (HP:0006536)3.51854871
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.41116552
24Prostate neoplasm (HP:0100787)3.40014498
25Systemic lupus erythematosus (HP:0002725)3.28773464
26Periodontitis (HP:0000704)3.25736593
27Chronic mucocutaneous candidiasis (HP:0002728)3.22490269
28Recurrent cutaneous fungal infections (HP:0011370)3.22490269
29Increased IgM level (HP:0003496)3.19924130
30Pustule (HP:0200039)3.19758098
31Leukocytosis (HP:0001974)3.19279654
32Pulmonary infiltrates (HP:0002113)3.04751044
33Chronic otitis media (HP:0000389)3.03122750
34Abnormality of T cell number (HP:0011839)3.02924043
35Abnormality of liposaccharide metabolism (HP:0010968)2.93658522
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.93658522
37Abnormality of glycolipid metabolism (HP:0010969)2.93658522
38Thick nail (HP:0001805)2.87500055
39Basal ganglia calcification (HP:0002135)2.86699330
40T lymphocytopenia (HP:0005403)2.85715839
41Meningitis (HP:0001287)2.85260590
42Eosinophilia (HP:0001880)2.75565472
43Arterial thrombosis (HP:0004420)2.71182789
44Cellulitis (HP:0100658)2.68814700
45Urticaria (HP:0001025)2.62052954
46Hemoptysis (HP:0002105)2.59994986
47Keratoconjunctivitis sicca (HP:0001097)2.59112578
48Dysostosis multiplex (HP:0000943)2.49956678
49Prolonged bleeding time (HP:0003010)2.49749937
50Episodic fever (HP:0001954)2.48341471
51Axonal loss (HP:0003447)2.48181530
52Tetraparesis (HP:0002273)2.46413316
53Disinhibition (HP:0000734)2.45383915
54Hematochezia (HP:0002573)2.45346334
55Increased serum ferritin (HP:0003281)2.45013160
56Osteomyelitis (HP:0002754)2.44075017
57Petechiae (HP:0000967)2.43324586
58Gastrointestinal infarctions (HP:0005244)2.43045212
59Pulmonary embolism (HP:0002204)2.42987369
60Recurrent pneumonia (HP:0006532)2.42478005
61Gangrene (HP:0100758)2.40504380
62Gingival bleeding (HP:0000225)2.38496458
63Hypergammaglobulinemia (HP:0010702)2.36890299
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.36757483
65Keratoconjunctivitis (HP:0001096)2.36688583
66Mutism (HP:0002300)2.36468441
67Premature loss of primary teeth (HP:0006323)2.35195684
68Purpura (HP:0000979)2.34859177
69Abnormality of eosinophils (HP:0001879)2.34523404
70Epistaxis (HP:0000421)2.34021306
71Nasal polyposis (HP:0100582)2.32289697
72Panhypogammaglobulinemia (HP:0003139)2.31572017
73Thyroiditis (HP:0100646)2.28170878
74Granulocytopenia (HP:0001913)2.25369152
75Glomerulonephritis (HP:0000099)2.24160186
76Myocardial infarction (HP:0001658)2.23978281
77Abnormality of polysaccharide metabolism (HP:0011012)2.23540106
78Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23540106
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23540106
80Polyneuropathy (HP:0001271)2.22959097
81Autoimmune hemolytic anemia (HP:0001890)2.21632917
82Urinary glycosaminoglycan excretion (HP:0003541)2.16644125
83Mucopolysacchariduria (HP:0008155)2.16644125
84Colitis (HP:0002583)2.16401591
85Inflammation of the large intestine (HP:0002037)2.16212535
86Hepatosplenomegaly (HP:0001433)2.15182264
87Loss of speech (HP:0002371)2.14495921
88Abnormality of the prostate (HP:0008775)2.13466099
89Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13403613
90Abnormality of T cells (HP:0002843)2.13145259
91Abnormality of the pleura (HP:0002103)2.13037691
92Interstitial pulmonary disease (HP:0006530)2.11086036
93Amyloidosis (HP:0011034)2.10812811
94Bone pain (HP:0002653)2.10779170
95Abnormality of iron homeostasis (HP:0011031)2.08707106
96Cheilitis (HP:0100825)2.06907100
97Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04164689
98Recurrent lower respiratory tract infections (HP:0002783)2.03170797
99Abnormality of the fingertips (HP:0001211)2.02978785
100Gastrointestinal inflammation (HP:0004386)2.02297422
101Neuronal loss in central nervous system (HP:0002529)2.01772889
102Increased IgE level (HP:0003212)2.01527559
103Pathologic fracture (HP:0002756)1.99999309
104Spontaneous hematomas (HP:0007420)1.99657937
105Recurrent bronchitis (HP:0002837)1.99185438
106Vertigo (HP:0002321)1.98865254
107Glomerulopathy (HP:0100820)1.98801976
108Sepsis (HP:0100806)1.98627508
109Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97932852
110Arthralgia (HP:0002829)1.97706764
111Abnormality of the nasal mucosa (HP:0000433)1.97625127
112Restrictive lung disease (HP:0002091)1.97254035
113Severe combined immunodeficiency (HP:0004430)1.96420975
114Chronic diarrhea (HP:0002028)1.96343334
115Anorexia (HP:0002039)1.95987732
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.95418581
117Lymphopenia (HP:0001888)1.92844930
118Gastrointestinal stroma tumor (HP:0100723)1.92831458
119Encephalitis (HP:0002383)1.92406517
120Joint swelling (HP:0001386)1.91290064
121Chest pain (HP:0100749)1.90966322
122Abnormality of the endocardium (HP:0004306)1.90675738
123Amaurosis fugax (HP:0100576)1.88239209
124Acne (HP:0001061)1.86449280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.70736570
2RIPK43.93518366
3TYK23.44767943
4MAP4K13.41107631
5TBK13.27326597
6TXK3.19400407
7IRAK43.06449265
8IKBKE2.96567790
9IRAK32.95144505
10JAK32.87329393
11PRPF4B2.86004973
12BLK2.77610024
13MAP3K132.76277790
14JAK12.39289390
15IKBKB2.37095268
16KIT2.15545041
17ZAP701.86717244
18SIK31.77899047
19TAOK11.73081772
20MAP3K111.70997565
21CSK1.69909670
22CHUK1.69232637
23SIK21.65867768
24TNK21.58367873
25HCK1.54677431
26SYK1.53771775
27TAOK21.52599540
28TAOK31.44083575
29MARK31.38818597
30LCK1.37814403
31ERN11.37102739
32CSF1R1.34873616
33CDK121.27597303
34RPS6KA41.25870221
35MAP3K11.24886180
36FES1.24012697
37ITK1.22273172
38EPHB11.21661953
39STK101.20674055
40TGFBR21.20414183
41BTK1.15475539
42JAK21.10007382
43LYN1.08733561
44CDC42BPA1.07953673
45PIM11.04914398
46FGR1.02565594
47TEC1.01283814
48FGFR31.00227082
49MAP3K100.96624378
50PIM20.96475982
51FGFR40.95024274
52CAMK1D0.92985325
53CAMKK20.92091042
54KSR20.82771332
55TESK20.82628208
56PBK0.82154803
57NEK90.82123986
58YES10.79622773
59DDR20.78667061
60MARK20.75985065
61STK40.72230732
62EIF2AK20.71891458
63PTK60.70913554
64TTN0.70764761
65MOS0.70604208
66BMPR20.70098078
67ACVR1B0.66832883
68CLK10.66282025
69MAP2K30.64541092
70CAMK1G0.64073692
71NME20.62769876
72MAPK70.61168029
73TRPM70.61157660
74ABL10.61008652
75PRKCQ0.60872448
76GRK60.60404380
77TRIB30.59234303
78EGFR0.58004137
79MAPK120.57706146
80EPHA30.56829552
81SIK10.53636746
82CAMKK10.52789824
83MAP3K50.52746120
84PRKCD0.52721492
85NLK0.51479777
86HIPK20.51070008
87PRKD20.50727163
88MST40.47686010
89IRAK10.46680507
90MATK0.46648016
91PDGFRB0.46005867
92STK30.45757239
93TYRO30.44667470
94BMX0.43723221
95CDK40.42567580
96MAPKAPK20.41922403
97GRK70.39928006
98MAP3K30.39054257
99RPS6KA60.38086872
100MAP2K60.37936692
101DAPK20.37521786
102PKN10.36267094
103FYN0.36101691
104RIPK10.35807786
105CDK60.34888375
106PIK3CG0.33834162
107SMG10.33281164
108DYRK1B0.33151936
109PRKCH0.32735373
110NUAK10.32444119
111IRAK20.31864014
112MAPK40.31693428
113LRRK20.29290448
114PDK10.28460206
115SGK30.26183102
116DMPK0.26007123
117KSR10.25596711
118BRD40.25413361
119ADRBK20.25413206
120INSR0.24916124
121RPS6KC10.24250496
122RPS6KL10.24250496
123IGF1R0.22386316
124SGK10.22354151
125MELK0.22090757
126DAPK30.20108649
127SRC0.19820708
128PDPK10.19161541
129ABL20.19012135

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.22333512
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.93238388
3Graft-versus-host disease_Homo sapiens_hsa053322.93033697
4Allograft rejection_Homo sapiens_hsa053302.63952115
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.60130298
6* Osteoclast differentiation_Homo sapiens_hsa043802.52082353
7Staphylococcus aureus infection_Homo sapiens_hsa051502.48110889
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42523622
9* Measles_Homo sapiens_hsa051622.32780628
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.22391522
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17937453
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15936438
13Pertussis_Homo sapiens_hsa051332.13178463
14Malaria_Homo sapiens_hsa051442.11417954
15Legionellosis_Homo sapiens_hsa051342.06796964
16Tuberculosis_Homo sapiens_hsa051522.04854653
17Intestinal immune network for IgA production_Homo sapiens_hsa046722.03497016
18* TNF signaling pathway_Homo sapiens_hsa046681.91316158
19* Influenza A_Homo sapiens_hsa051641.90872255
20Primary immunodeficiency_Homo sapiens_hsa053401.88673571
21Rheumatoid arthritis_Homo sapiens_hsa053231.82768726
22* B cell receptor signaling pathway_Homo sapiens_hsa046621.82491519
23* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.78253285
24Herpes simplex infection_Homo sapiens_hsa051681.71543125
25Asthma_Homo sapiens_hsa053101.66068424
26Lysosome_Homo sapiens_hsa041421.64836713
27Antigen processing and presentation_Homo sapiens_hsa046121.64822042
28Hematopoietic cell lineage_Homo sapiens_hsa046401.64626938
29* Toxoplasmosis_Homo sapiens_hsa051451.61047804
30Type I diabetes mellitus_Homo sapiens_hsa049401.55023002
31* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50580013
32African trypanosomiasis_Homo sapiens_hsa051431.49634365
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.49068549
34* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47012885
35* T cell receptor signaling pathway_Homo sapiens_hsa046601.43222728
36* Chemokine signaling pathway_Homo sapiens_hsa040621.41771576
37* Apoptosis_Homo sapiens_hsa042101.40703814
38Shigellosis_Homo sapiens_hsa051311.39193336
39* Jak-STAT signaling pathway_Homo sapiens_hsa046301.36188456
40Phagosome_Homo sapiens_hsa041451.35789896
41Salmonella infection_Homo sapiens_hsa051321.35461921
42Autoimmune thyroid disease_Homo sapiens_hsa053201.34106570
43Other glycan degradation_Homo sapiens_hsa005111.32815933
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28290473
45Viral myocarditis_Homo sapiens_hsa054161.22237145
46* Hepatitis B_Homo sapiens_hsa051611.21454498
47* Hepatitis C_Homo sapiens_hsa051601.10817485
48* Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01874207
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95549913
50* Leukocyte transendothelial migration_Homo sapiens_hsa046700.91151593
51* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89012742
52* Acute myeloid leukemia_Homo sapiens_hsa052210.88565660
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86854250
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86768954
55* Chronic myeloid leukemia_Homo sapiens_hsa052200.81418633
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79470517
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72292110
58* Epstein-Barr virus infection_Homo sapiens_hsa051690.70885416
59* Neurotrophin signaling pathway_Homo sapiens_hsa047220.68436658
60* Non-small cell lung cancer_Homo sapiens_hsa052230.68168531
61* Pancreatic cancer_Homo sapiens_hsa052120.67380796
62* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66280111
63* Prolactin signaling pathway_Homo sapiens_hsa049170.64949573
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63790781
65* Amoebiasis_Homo sapiens_hsa051460.62195260
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.60701920
67Notch signaling pathway_Homo sapiens_hsa043300.57520499
68* Platelet activation_Homo sapiens_hsa046110.57345374
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55784329
70Caffeine metabolism_Homo sapiens_hsa002320.54173094
71* Renal cell carcinoma_Homo sapiens_hsa052110.53897803
72* Type II diabetes mellitus_Homo sapiens_hsa049300.53760499
73Bladder cancer_Homo sapiens_hsa052190.53521159
74* Small cell lung cancer_Homo sapiens_hsa052220.51989701
75* HTLV-I infection_Homo sapiens_hsa051660.51389201
76* Viral carcinogenesis_Homo sapiens_hsa052030.47874546
77GnRH signaling pathway_Homo sapiens_hsa049120.47089520
78Collecting duct acid secretion_Homo sapiens_hsa049660.45141799
79* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45027837
80* Sphingolipid signaling pathway_Homo sapiens_hsa040710.44926270
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43907759
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41575761
83MicroRNAs in cancer_Homo sapiens_hsa052060.41453694
84Dorso-ventral axis formation_Homo sapiens_hsa043200.37914223
85Endocytosis_Homo sapiens_hsa041440.36986319
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36961402
87* HIF-1 signaling pathway_Homo sapiens_hsa040660.36056404
88MAPK signaling pathway_Homo sapiens_hsa040100.33995945
89* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31752083
90* FoxO signaling pathway_Homo sapiens_hsa040680.31413015
91Inositol phosphate metabolism_Homo sapiens_hsa005620.31076685
92* Insulin resistance_Homo sapiens_hsa049310.30909029
93Prion diseases_Homo sapiens_hsa050200.30251221
94Sphingolipid metabolism_Homo sapiens_hsa006000.27793535
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27657839
96* Proteoglycans in cancer_Homo sapiens_hsa052050.27072547
97* Choline metabolism in cancer_Homo sapiens_hsa052310.25752174
98* mTOR signaling pathway_Homo sapiens_hsa041500.24542289
99* VEGF signaling pathway_Homo sapiens_hsa043700.24171627
100* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22292279
101p53 signaling pathway_Homo sapiens_hsa041150.21944222
102* Rap1 signaling pathway_Homo sapiens_hsa040150.21209559
103* Prostate cancer_Homo sapiens_hsa052150.20052393
104* Colorectal cancer_Homo sapiens_hsa052100.19265224
105Mineral absorption_Homo sapiens_hsa049780.18965011
106* Endometrial cancer_Homo sapiens_hsa052130.18886837
107Complement and coagulation cascades_Homo sapiens_hsa046100.17292655
108* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17114691
109ABC transporters_Homo sapiens_hsa020100.16360224
110* Phospholipase D signaling pathway_Homo sapiens_hsa040720.14292162
111Adherens junction_Homo sapiens_hsa045200.13707866

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