PIK3R6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.37276591
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.37276591
3modulation by symbiont of host immune response (GO:0052553)6.37276591
4positive regulation by symbiont of host defense response (GO:0052509)6.37276591
5modulation by symbiont of host defense response (GO:0052031)6.37276591
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.37276591
7response to peptidoglycan (GO:0032494)5.62986170
8neutrophil activation involved in immune response (GO:0002283)5.29817310
9B cell receptor signaling pathway (GO:0050853)5.15631777
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.83957944
11macrophage activation involved in immune response (GO:0002281)4.83753151
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76291940
13positive regulation of interferon-alpha production (GO:0032727)4.71036850
14detection of bacterium (GO:0016045)4.62343578
15respiratory burst (GO:0045730)4.60387858
16regulation of interferon-alpha production (GO:0032647)4.45628285
17regulation of interferon-beta biosynthetic process (GO:0045357)4.44824926
18detection of other organism (GO:0098543)4.43990276
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.42608111
20immunoglobulin mediated immune response (GO:0016064)4.41725110
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.38853717
22response to host immune response (GO:0052572)4.38853717
23regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.34537951
24response to muramyl dipeptide (GO:0032495)4.28457804
25positive regulation of cellular amide metabolic process (GO:0034250)4.24290883
26positive regulation of gamma-delta T cell activation (GO:0046645)4.19089020
27granulocyte activation (GO:0036230)4.16866912
28neutrophil activation (GO:0042119)4.15044123
29B cell homeostasis (GO:0001782)4.14581648
30microglial cell activation (GO:0001774)4.10430193
31cellular extravasation (GO:0045123)4.09179524
32lipopolysaccharide-mediated signaling pathway (GO:0031663)4.07823732
33regulation of gamma-delta T cell activation (GO:0046643)4.04875332
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95442831
35response to host (GO:0075136)3.95442831
36response to host defenses (GO:0052200)3.95442831
37negative thymic T cell selection (GO:0045060)3.90157427
38positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.82840323
39positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.80108572
40neutrophil mediated immunity (GO:0002446)3.78812889
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70270868
42positive regulation of antigen processing and presentation (GO:0002579)3.61170897
43hydrogen peroxide biosynthetic process (GO:0050665)3.58525570
44negative T cell selection (GO:0043383)3.57066859
45myeloid cell activation involved in immune response (GO:0002275)3.56176958
46regulation of alpha-beta T cell proliferation (GO:0046640)3.56024410
47T-helper 1 type immune response (GO:0042088)3.55712053
48superoxide anion generation (GO:0042554)3.55708741
49macrophage activation (GO:0042116)3.55286930
50regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.54849445
51positive regulation of humoral immune response (GO:0002922)3.53115176
52defense response to protozoan (GO:0042832)3.52766511
53regulation of B cell differentiation (GO:0045577)3.52647752
54B cell proliferation (GO:0042100)3.52547036
55detection of external biotic stimulus (GO:0098581)3.51572599
56T cell lineage commitment (GO:0002360)3.50735920
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.49686629
58production of molecular mediator involved in inflammatory response (GO:0002532)3.48122636
59negative regulation of interleukin-12 production (GO:0032695)3.47362698
60cellular response to interferon-gamma (GO:0071346)3.46910604
61positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.46858965
62positive regulation of macrophage cytokine production (GO:0060907)3.46465210
63detection of molecule of bacterial origin (GO:0032490)3.45384410
64positive regulation of mast cell activation (GO:0033005)3.44951431
65positive regulation of mast cell activation involved in immune response (GO:0033008)3.44824911
66positive regulation of mast cell degranulation (GO:0043306)3.44824911
67positive thymic T cell selection (GO:0045059)3.44163580
68positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.42561974
69reactive oxygen species biosynthetic process (GO:1903409)3.37200534
70positive regulation of interferon-beta production (GO:0032728)3.36421778
71positive regulation of chemokine biosynthetic process (GO:0045080)3.36277104
72regulation of activation of Janus kinase activity (GO:0010533)3.33822581
73natural killer cell mediated cytotoxicity (GO:0042267)3.33765650
74natural killer cell mediated immunity (GO:0002228)3.33765650
75regulation of B cell receptor signaling pathway (GO:0050855)3.33400899
76positive regulation of B cell mediated immunity (GO:0002714)3.33332185
77positive regulation of immunoglobulin mediated immune response (GO:0002891)3.33332185
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.32117906
79cellular response to type I interferon (GO:0071357)3.29668927
80type I interferon signaling pathway (GO:0060337)3.29668927
81response to type I interferon (GO:0034340)3.28161623
82regulation of mast cell degranulation (GO:0043304)3.27679252
83negative regulation of T cell mediated immunity (GO:0002710)3.27321117
84regulation of interferon-gamma biosynthetic process (GO:0045072)3.27066465
85positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.24898216
86leukocyte mediated cytotoxicity (GO:0001909)3.23998033
87response to interleukin-15 (GO:0070672)3.22969823
88T cell costimulation (GO:0031295)3.22806995
89regulation of B cell proliferation (GO:0030888)3.22739078
90leukocyte aggregation (GO:0070486)3.22677119
91interferon-gamma-mediated signaling pathway (GO:0060333)3.22550950
92negative regulation of growth of symbiont in host (GO:0044130)3.22105161
93negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.22105161
94modulation of growth of symbiont involved in interaction with host (GO:0044144)3.22105161
95regulation of growth of symbiont in host (GO:0044126)3.22105161
96positive regulation of B cell differentiation (GO:0045579)3.21735681
97negative regulation of B cell proliferation (GO:0030889)3.21249134
98monocyte chemotaxis (GO:0002548)3.21017940
99antigen processing and presentation of endogenous antigen (GO:0019883)3.20988605
100cellular response to interleukin-15 (GO:0071350)3.20867216
101B cell mediated immunity (GO:0019724)3.19242508
102response to protozoan (GO:0001562)3.17947409
103lymphocyte costimulation (GO:0031294)3.17915510
104positive regulation of interleukin-12 production (GO:0032735)3.17662417
105myeloid dendritic cell differentiation (GO:0043011)3.17266990
106cellular response to zinc ion (GO:0071294)3.15961858
107adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.15856747
108positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.15110464
109regulation of interleukin-2 biosynthetic process (GO:0045076)3.14815633
110lymphocyte homeostasis (GO:0002260)3.12532756
111negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.12379402
112thymic T cell selection (GO:0045061)3.11470353
113regulation of chemokine biosynthetic process (GO:0045073)3.11115557
114regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.10912712
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08377243
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.08377243
117negative regulation of lymphocyte mediated immunity (GO:0002707)3.08318679
118positive regulation of B cell proliferation (GO:0030890)3.07755214
119negative regulation of phagocytosis (GO:0050765)3.06632939
120negative regulation of interleukin-17 production (GO:0032700)3.06378822
121positive regulation of cytokine biosynthetic process (GO:0042108)3.05733560
122positive regulation of B cell activation (GO:0050871)3.04104727
123regulation of mast cell activation involved in immune response (GO:0033006)3.03634304
124detection of biotic stimulus (GO:0009595)3.03065772
125regulation of macrophage cytokine production (GO:0010935)3.02443896
126myeloid dendritic cell activation (GO:0001773)3.01282584
127response to interferon-gamma (GO:0034341)3.01042428
128positive regulation of alpha-beta T cell proliferation (GO:0046641)3.00571907
129regulation of antigen processing and presentation (GO:0002577)2.98872464
130regulation of T-helper 1 cell differentiation (GO:0045625)2.97307194
131cytokine secretion (GO:0050663)2.96460320
132myeloid leukocyte activation (GO:0002274)2.95156924
133regulation of interleukin-12 production (GO:0032655)2.94869678
134myeloid leukocyte mediated immunity (GO:0002444)2.92993903
135positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90873184
136NIK/NF-kappaB signaling (GO:0038061)2.90616215
137neutrophil chemotaxis (GO:0030593)2.90570259
138regulation of mast cell activation (GO:0033003)2.90209328
139germinal center formation (GO:0002467)2.89382129
140positive regulation of interleukin-17 production (GO:0032740)2.86908556
141T cell migration (GO:0072678)2.86717771
142negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.84558598
143negative regulation of cell killing (GO:0031342)2.84558598
144regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.84259219
145pinocytosis (GO:0006907)2.82891029
146neutrophil migration (GO:1990266)2.82130622
147negative regulation of myeloid cell apoptotic process (GO:0033033)2.81828825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.98947277
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.38574618
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.35320827
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.59093255
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.28360769
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.94538622
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.76484394
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.74064360
9* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.49048783
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.47179236
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.35924476
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34702995
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33416008
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.85359219
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.83806304
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81539018
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61962456
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.60775222
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52938774
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.50637024
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39905473
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.37689765
23SPI1_23547873_ChIP-Seq_NB4_Human2.30694718
24SCL_19346495_ChIP-Seq_HPC-7_Human2.27377757
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21238262
26* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.19605857
27SPI1_23127762_ChIP-Seq_K562_Human2.08390224
28VDR_24763502_ChIP-Seq_THP-1_Human1.99057890
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92313549
30VDR_21846776_ChIP-Seq_THP-1_Human1.87009722
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85080809
32CIITA_25753668_ChIP-Seq_RAJI_Human1.81547480
33VDR_24787735_ChIP-Seq_THP-1_Human1.80212142
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77763526
35* PU_27001747_Chip-Seq_BMDM_Mouse1.77051591
36RUNX_20019798_ChIP-Seq_JUKART_Human1.76191845
37* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74138238
38* MAF_26560356_Chip-Seq_TH1_Human1.72204873
39CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66636684
40* MYB_26560356_Chip-Seq_TH2_Human1.66246420
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66037647
42GATA1_22025678_ChIP-Seq_K562_Human1.64759883
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63529432
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63281422
45* RUNX1_22412390_ChIP-Seq_EML_Mouse1.62201976
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.60609326
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55377417
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55176784
49MYB_26560356_Chip-Seq_TH1_Human1.52465077
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.49378617
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.48431128
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47705864
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44147964
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39931853
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32498735
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32240912
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.30725370
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29161608
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27586325
60* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24673942
61ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23732393
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.23696987
63* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23004541
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21234600
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17783811
66GATA3_27048872_Chip-Seq_THYMUS_Human1.17415215
67UTX_26944678_Chip-Seq_JUKART_Human1.17169924
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16033866
69* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14686623
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14319867
71* TCF7_22412390_ChIP-Seq_EML_Mouse1.14039879
72GATA3_26560356_Chip-Seq_TH2_Human1.13872842
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11268262
74BCL6_27268052_Chip-Seq_Bcells_Human1.10721268
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10046024
76* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09531370
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06544141
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.05658290
79BCOR_27268052_Chip-Seq_Bcells_Human1.05107711
80* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04868128
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03578967
82SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02956229
83NCOR1_26117541_ChIP-Seq_K562_Human1.02157435
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01979953
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01595477
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97843349
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97127524
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95581334
89* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90533001
90MAF_26560356_Chip-Seq_TH2_Human0.88271158
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.87970243
92RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87454412
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86073820
94GATA1_19941826_ChIP-Seq_K562_Human0.85518285
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85249209
96GATA2_19941826_ChIP-Seq_K562_Human0.84334988
97TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83052202
98KDM2B_26808549_Chip-Seq_DND41_Human0.81312911
99* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81123540
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79020175
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78490738
102SPI1_20517297_ChIP-Seq_HL60_Human0.78081360
103MYC_22102868_ChIP-Seq_BL_Human0.75817204
104IKZF1_21737484_ChIP-ChIP_HCT116_Human0.72978630
105RARG_19884340_ChIP-ChIP_MEFs_Mouse0.71089132
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70863901
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.69952265
108FOXM1_23109430_ChIP-Seq_U2OS_Human0.68061593
109TFEB_21752829_ChIP-Seq_HELA_Human0.65130600
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64851923
111EGR1_19032775_ChIP-ChIP_M12_Human0.63984869
112CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62406476
113SMRT_27268052_Chip-Seq_Bcells_Human0.62088592
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61232049
115LXR_22292898_ChIP-Seq_THP-1_Human0.60137584
116* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59585280
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.58365482
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57950738
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57950738
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.57607836

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38068664
2MP0003436_decreased_susceptibility_to3.70315720
3MP0009785_altered_susceptibility_to3.64610329
4MP0003303_peritoneal_inflammation3.53279484
5MP0002419_abnormal_innate_immunity3.30736600
6MP0002148_abnormal_hypersensitivity_rea3.26291347
7MP0005000_abnormal_immune_tolerance2.93371355
8MP0003724_increased_susceptibility_to2.92083671
9MP0004510_myositis2.91058934
10MP0005025_abnormal_response_to2.89741204
11MP0006082_CNS_inflammation2.77950754
12MP0005058_abnormal_lysosome_morphology2.70051953
13MP0001790_abnormal_immune_system2.64426216
14MP0005387_immune_system_phenotype2.64426216
15MP0002452_abnormal_antigen_presenting2.63820655
16MP0000685_abnormal_immune_system2.60905628
17MP0005671_abnormal_response_to2.58471602
18MP0001800_abnormal_humoral_immune2.50715917
19MP0002723_abnormal_immune_serum2.45063588
20MP0009278_abnormal_bone_marrow2.42942420
21MP0005167_abnormal_blood-brain_barrier2.32422707
22MP0001819_abnormal_immune_cell2.22620488
23MP0002420_abnormal_adaptive_immunity2.18117958
24MP0005464_abnormal_platelet_physiology2.16939567
25MP0000569_abnormal_digit_pigmentation2.11180972
26MP0001533_abnormal_skeleton_physiology2.05603880
27MP0003172_abnormal_lysosome_physiology2.03988929
28MP0001853_heart_inflammation1.91829725
29MP0000343_altered_response_to1.91376907
30MP0009840_abnormal_foam_cell1.90346208
31MP0002405_respiratory_system_inflammati1.86522322
32MP0009764_decreased_sensitivity_to1.82825946
33MP0001845_abnormal_inflammatory_respons1.81466974
34MP0004947_skin_inflammation1.76374211
35MP0005645_abnormal_hypothalamus_physiol1.74236573
36MP0003448_altered_tumor_morphology1.73538884
37MP0008469_abnormal_protein_level1.71433002
38MP0003075_altered_response_to1.69148411
39MP0001545_abnormal_hematopoietic_system1.66794879
40MP0005397_hematopoietic_system_phenotyp1.66794879
41MP0003191_abnormal_cellular_cholesterol1.64724027
42MP0000716_abnormal_immune_system1.55595002
43MP0010155_abnormal_intestine_physiology1.54858901
44MP0003828_pulmonary_edema1.53125470
45MP0002006_tumorigenesis1.48692562
46MP0003183_abnormal_peptide_metabolism1.46306878
47MP0002398_abnormal_bone_marrow1.46261928
48MP0002998_abnormal_bone_remodeling1.38803742
49MP0009333_abnormal_splenocyte_physiolog1.35722211
50MP0008260_abnormal_autophagy1.34330202
51MP0000689_abnormal_spleen_morphology1.28687708
52MP0002429_abnormal_blood_cell1.27153067
53MP0005310_abnormal_salivary_gland1.25752018
54MP0002166_altered_tumor_susceptibility1.24528542
55MP0005166_decreased_susceptibility_to1.23530163
56MP0000858_altered_metastatic_potential1.20329837
57MP0008057_abnormal_DNA_replication1.16992498
58MP0003045_fibrosis1.15541961
59MP0003300_gastrointestinal_ulcer1.15488416
60MP0002722_abnormal_immune_system1.13284773
61MP0003690_abnormal_glial_cell1.09336484
62MP0002139_abnormal_hepatobiliary_system1.08496419
63MP0004808_abnormal_hematopoietic_stem1.05716783
64MP0009763_increased_sensitivity_to1.04475663
65MP0005076_abnormal_cell_differentiation1.03647262
66MP0001879_abnormal_lymphatic_vessel1.02176030
67MP0005164_abnormal_response_to1.01679094
68MP0003566_abnormal_cell_adhesion1.01183243
69MP0005174_abnormal_tail_pigmentation1.00708879
70MP0000604_amyloidosis0.99759075
71MP0001851_eye_inflammation0.99371722
72MP0000249_abnormal_blood_vessel0.96776666
73MP0003866_abnormal_defecation0.94150186
74MP0010307_abnormal_tumor_latency0.92849428
75MP0002138_abnormal_hepatobiliary_system0.92822293
76MP0004381_abnormal_hair_follicle0.91641996
77MP0001873_stomach_inflammation0.90967469
78MP0002019_abnormal_tumor_incidence0.90282483
79MP0000767_abnormal_smooth_muscle0.89634045
80MP0005390_skeleton_phenotype0.85556188
81MP0000490_abnormal_crypts_of0.85479734
82MP0001348_abnormal_lacrimal_gland0.83420939
83MP0002396_abnormal_hematopoietic_system0.83267324
84MP0008874_decreased_physiological_sensi0.81274161
85MP0002332_abnormal_exercise_endurance0.79014563
86MP0003091_abnormal_cell_migration0.77127299
87MP0000465_gastrointestinal_hemorrhage0.76836153
88MP0002132_abnormal_respiratory_system0.76633110
89MP0000371_diluted_coat_color0.76513413
90MP0000015_abnormal_ear_pigmentation0.76055777
91MP0005075_abnormal_melanosome_morpholog0.75193422
92MP0004782_abnormal_surfactant_physiolog0.74944185
93MP0003646_muscle_fatigue0.73949498
94MP0003806_abnormal_nucleotide_metabolis0.72683815
95MP0002933_joint_inflammation0.72314684
96MP0004883_abnormal_blood_vessel0.70032777
97MP0002693_abnormal_pancreas_physiology0.69666463
98MP0000372_irregular_coat_pigmentation0.65801162
99MP0002254_reproductive_system_inflammat0.65715435
100MP0009765_abnormal_xenobiotic_induced0.65558514
101MP0002136_abnormal_kidney_physiology0.65511028
102MP0005670_abnormal_white_adipose0.64166638
103MP0001958_emphysema0.64066619
104MP0003763_abnormal_thymus_physiology0.63594509
105MP0001663_abnormal_digestive_system0.63310697
106MP0003705_abnormal_hypodermis_morpholog0.59696561
107MP0005451_abnormal_body_composition0.58073609
108MP0004130_abnormal_muscle_cell0.57424867
109MP0000313_abnormal_cell_death0.57137114
110MP0010368_abnormal_lymphatic_system0.57011650
111MP0003279_aneurysm0.56931063
112MP0003795_abnormal_bone_structure0.56707161
113MP0010094_abnormal_chromosome_stability0.56423243
114MP0000703_abnormal_thymus_morphology0.56145617
115MP0005623_abnormal_meninges_morphology0.56093064
116MP0003186_abnormal_redox_activity0.54900997
117MP0003656_abnormal_erythrocyte_physiolo0.54242205
118MP0003453_abnormal_keratinocyte_physiol0.53937124
119MP0005165_increased_susceptibility_to0.53312216
120MP0002928_abnormal_bile_duct0.52953674
121MP0002163_abnormal_gland_morphology0.52919808
122MP0000609_abnormal_liver_physiology0.50721877
123MP0005621_abnormal_cell_physiology0.49385265

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.51497051
2Recurrent bacterial skin infections (HP:0005406)6.90733493
3Eczematoid dermatitis (HP:0000976)6.74823639
4Gastrointestinal stroma tumor (HP:0100723)6.48978098
5Recurrent gram-negative bacterial infections (HP:0005420)5.99441017
6Agammaglobulinemia (HP:0004432)5.62559947
7Recurrent sinusitis (HP:0011108)5.38910683
8Abnormality of macrophages (HP:0004311)5.07141230
9IgA deficiency (HP:0002720)4.93421144
10Mediastinal lymphadenopathy (HP:0100721)4.92786236
11Elevated erythrocyte sedimentation rate (HP:0003565)4.71069875
12IgM deficiency (HP:0002850)4.67676456
13Myositis (HP:0100614)4.52506354
14Systemic lupus erythematosus (HP:0002725)4.49853607
15Lymphopenia (HP:0001888)4.39792452
16Orchitis (HP:0100796)4.35040519
17Abnormality of cells of the lymphoid lineage (HP:0012140)4.14195042
18Autoimmune thrombocytopenia (HP:0001973)4.14107000
19Optic neuritis (HP:0100653)4.11543890
20Retrobulbar optic neuritis (HP:0100654)4.11543890
21Recurrent bronchitis (HP:0002837)4.09854280
22Recurrent skin infections (HP:0001581)4.09806373
23Obstructive lung disease (HP:0006536)4.08343933
24Chronic obstructive pulmonary disease (HP:0006510)4.08343933
25Gingivitis (HP:0000230)4.07264666
26Panhypogammaglobulinemia (HP:0003139)3.92901218
27Recurrent fungal infections (HP:0002841)3.74499462
28Emphysema (HP:0002097)3.67513834
29Vasculitis (HP:0002633)3.66961872
30Stomatitis (HP:0010280)3.65584847
31Vacuolated lymphocytes (HP:0001922)3.55438966
32Restrictive lung disease (HP:0002091)3.51901017
33Increased cerebral lipofuscin (HP:0011813)3.49551501
34Abnormality of T cell physiology (HP:0011840)3.47374322
35Periodontitis (HP:0000704)3.34410746
36Hematochezia (HP:0002573)3.34049586
37Increased IgE level (HP:0003212)3.33128300
38Gastrointestinal infarctions (HP:0005244)3.31309543
39Cellulitis (HP:0100658)3.28694064
40IgG deficiency (HP:0004315)3.27509284
41Encephalitis (HP:0002383)3.27181205
42Abnormality of glycolipid metabolism (HP:0010969)3.26817721
43Abnormality of liposaccharide metabolism (HP:0010968)3.26817721
44Abnormality of glycosphingolipid metabolism (HP:0004343)3.26817721
45Recurrent viral infections (HP:0004429)3.25861170
46Pustule (HP:0200039)3.22330542
47Increased neuronal autofluorescent lipopigment (HP:0002074)3.20330574
48Thick nail (HP:0001805)3.12523831
49Glomerulonephritis (HP:0000099)3.09392686
50Basal ganglia calcification (HP:0002135)3.09307245
51Spontaneous hematomas (HP:0007420)3.06886636
52Axonal loss (HP:0003447)3.05391247
53Meningitis (HP:0001287)2.96755639
54Chronic diarrhea (HP:0002028)2.96093867
55Abnormality of T cells (HP:0002843)2.92691486
56Hemoptysis (HP:0002105)2.91998717
57Pulmonary infiltrates (HP:0002113)2.88665759
58Arterial thrombosis (HP:0004420)2.86267010
59Increased IgM level (HP:0003496)2.86040592
60Prostate neoplasm (HP:0100787)2.77728362
61Urticaria (HP:0001025)2.77418183
62Interstitial pulmonary disease (HP:0006530)2.68832580
63Chronic mucocutaneous candidiasis (HP:0002728)2.68223350
64Recurrent cutaneous fungal infections (HP:0011370)2.68223350
65B lymphocytopenia (HP:0010976)2.66798127
66Viral hepatitis (HP:0006562)2.66794642
67Verrucae (HP:0200043)2.64394728
68Papilloma (HP:0012740)2.64394728
69Autoimmune hemolytic anemia (HP:0001890)2.63810965
70Keratoconjunctivitis sicca (HP:0001097)2.61181460
71Leukocytosis (HP:0001974)2.58624379
72Purpura (HP:0000979)2.57600814
73Osteomyelitis (HP:0002754)2.57114372
74Disinhibition (HP:0000734)2.54722032
75Skin rash (HP:0000988)2.54358653
76Nephritis (HP:0000123)2.53903045
77Leukopenia (HP:0001882)2.50843427
78Hypertensive crisis (HP:0100735)2.50627690
79Abnormality of B cell number (HP:0010975)2.50587792
80Recurrent pneumonia (HP:0006532)2.49684395
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.49201442
82Tetraparesis (HP:0002273)2.48510399
83Lymphoma (HP:0002665)2.47864836
84Sepsis (HP:0100806)2.46160571
85Prolonged bleeding time (HP:0003010)2.44840591
86Dysostosis multiplex (HP:0000943)2.44821028
87Joint hemorrhage (HP:0005261)2.44671444
88Chest pain (HP:0100749)2.44350109
89Abnormality of the prostate (HP:0008775)2.43001395
90Gingival bleeding (HP:0000225)2.41519167
91Chronic otitis media (HP:0000389)2.41337736
92Hypergammaglobulinemia (HP:0010702)2.39131449
93Colitis (HP:0002583)2.38426213
94Keratoconjunctivitis (HP:0001096)2.38153860
95Basal cell carcinoma (HP:0002671)2.33097294
96Xerostomia (HP:0000217)2.31715344
97Premature loss of primary teeth (HP:0006323)2.27798418
98Myocardial infarction (HP:0001658)2.27604367
99Porencephaly (HP:0002132)2.23918623
100Esophageal varix (HP:0002040)2.23630576
101Granulocytopenia (HP:0001913)2.22327065
102Eosinophilia (HP:0001880)2.19288559
103Loss of speech (HP:0002371)2.19106685
104Hepatosplenomegaly (HP:0001433)2.18335053
105Recurrent lower respiratory tract infections (HP:0002783)2.17691581
106Petechiae (HP:0000967)2.16065532
107Abnormality of the pleura (HP:0002103)2.15779983
108Bronchitis (HP:0012387)2.14765874
109Anorexia (HP:0002039)2.13392926
110Osteolytic defects of the hand bones (HP:0009699)2.12954889
111Osteolytic defects of the phalanges of the hand (HP:0009771)2.12954889
112Inflammation of the large intestine (HP:0002037)2.12447639
113Abnormality of the peritoneum (HP:0002585)2.12253095
114Amyloidosis (HP:0011034)2.11053468
115Abnormality of the nasal mucosa (HP:0000433)2.07909217
116Abnormality of the pericardium (HP:0001697)2.07011307
117Hepatitis (HP:0012115)2.05950146
118Recurrent otitis media (HP:0000403)2.03200430
119Bone pain (HP:0002653)2.02474182
120Acrocyanosis (HP:0001063)2.01714510
121Abnormality of T cell number (HP:0011839)2.01274435
122Dry hair (HP:0011359)2.00588197
123Agnosia (HP:0010524)2.00403551
124Epistaxis (HP:0000421)2.00138766
125Skin ulcer (HP:0200042)1.99960697
126Peritonitis (HP:0002586)1.97826664
127Abnormal delayed hypersensitivity skin test (HP:0002963)1.97392050
128Gangrene (HP:0100758)1.96597892
129Gastrointestinal inflammation (HP:0004386)1.96103450
130Poor head control (HP:0002421)1.94858439
131Squamous cell carcinoma (HP:0002860)1.94041049
132Abnormality of complement system (HP:0005339)1.93796492
133Urinary glycosaminoglycan excretion (HP:0003541)1.93327550
134Mucopolysacchariduria (HP:0008155)1.93327550
135Pulmonary fibrosis (HP:0002206)1.93039061
136Pulmonary embolism (HP:0002204)1.89257563
137T lymphocytopenia (HP:0005403)1.89062652
138Abnormality of polysaccharide metabolism (HP:0011012)1.85886675
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85886675
140Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85886675
141Progressive visual loss (HP:0000529)1.84808823
142Arthralgia (HP:0002829)1.83304722
143Pathologic fracture (HP:0002756)1.83169296
144Nasal polyposis (HP:0100582)1.82893321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.63120949
2MAP3K143.93966875
3PRPF4B3.48051030
4TBK13.42982503
5IRAK43.42915231
6IRAK33.42514691
7TYK23.42370642
8BLK3.40263563
9MAP4K12.85679367
10TGFBR22.52904105
11IKBKE2.45614376
12JAK32.36054485
13ERN12.24940301
14IKBKB2.23019638
15TIE12.21417503
16SMG12.07458770
17JAK12.03540009
18CSK1.81015937
19KIT1.74013614
20MAP3K131.68664680
21KDR1.61153150
22HCK1.50213544
23TXK1.49913559
24MARK31.46969703
25PBK1.42919762
26STK101.42795877
27FES1.42400955
28SYK1.39953138
29ZAP701.39722243
30CSF1R1.39325798
31VRK11.39153814
32EPHB11.31346310
33BTK1.30218520
34TNK21.29729606
35CHUK1.26539089
36TTN1.26516215
37TLK11.25634472
38MAP2K31.25444911
39JAK21.23584935
40FGR1.22767108
41GRK71.22758171
42CDC42BPA1.16606383
43CDK121.15572176
44LYN1.13078287
45SIK21.11000780
46PIM21.09090771
47PIM11.07898436
48CLK11.07017156
49RIPK11.05892450
50TAOK21.04468464
51TEC1.04397242
52LCK1.02041498
53MAP3K50.95740498
54STK40.95510879
55BMX0.94717841
56EIF2AK20.94597713
57CAMK1D0.93098037
58MATK0.89791684
59EEF2K0.89302716
60NEK90.88395030
61TAOK30.87170985
62MAPK110.85249974
63MAP3K100.85183455
64TRPM70.82785888
65PASK0.79584143
66BMPR20.77755667
67PTK60.77697790
68CDK190.75092576
69RPS6KA40.74496937
70RPS6KA50.73689170
71MAPK70.73677038
72EIF2AK30.73219086
73MAP3K110.72064460
74TESK20.67451704
75TAF10.66067822
76BCKDK0.65459563
77ZAK0.65137908
78EGFR0.62950225
79TRIB30.62315091
80PRKCD0.61867997
81CDK40.61484810
82ABL10.60162122
83PAK40.59845734
84ABL20.58475209
85PDK10.56621418
86PDPK10.56247083
87DDR20.55926891
88MAP3K30.55401649
89SIK30.54839864
90MOS0.54369524
91PTK2B0.54191117
92YES10.53928538
93PRKCH0.53319983
94RPS6KA60.53021743
95CCNB10.52411855
96MELK0.52163931
97HIPK20.50949792
98MAP3K80.50202057
99KSR20.48741055
100GRK60.47056838
101ITK0.46743118
102PDK20.45471869
103SIK10.44608861
104STK30.44543279
105CAMK1G0.44368859
106MAPK120.44045498
107RPS6KL10.43837516
108RPS6KC10.43837516
109IRAK20.43448369
110MAPKAPK20.41928184
111TAOK10.41725129
112PRKG20.41193645
113ALK0.39340125
114PIK3CG0.34611011
115LRRK20.33580739
116MAP3K120.33355534
117CDK90.33183679
118STK240.33022093
119IRAK10.32361782
120MST1R0.31772980
121DAPK30.31642519
122PRKCQ0.30385206
123FGFR40.30224328
124NME10.30168171
125RPS6KA20.29738440
126FGFR30.29443278
127MAPK40.29217876
128MAP3K10.28731070
129MAP3K90.26184132
130DMPK0.25393878
131FYN0.25285684
132NME20.24837485
133NEK20.24211167
134ARAF0.23500782

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.43257778
2Systemic lupus erythematosus_Homo sapiens_hsa053223.21267348
3Staphylococcus aureus infection_Homo sapiens_hsa051503.13223648
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.88639130
5Graft-versus-host disease_Homo sapiens_hsa053322.64992651
6Osteoclast differentiation_Homo sapiens_hsa043802.62917293
7Allograft rejection_Homo sapiens_hsa053302.55832353
8Legionellosis_Homo sapiens_hsa051342.52606458
9Pertussis_Homo sapiens_hsa051332.51483895
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.48004283
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.32143790
12Tuberculosis_Homo sapiens_hsa051522.25251636
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17929568
14Malaria_Homo sapiens_hsa051442.14582855
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.13404015
16Measles_Homo sapiens_hsa051622.11776071
17Influenza A_Homo sapiens_hsa051641.97405584
18Rheumatoid arthritis_Homo sapiens_hsa053231.95903631
19B cell receptor signaling pathway_Homo sapiens_hsa046621.94891038
20TNF signaling pathway_Homo sapiens_hsa046681.91266962
21Asthma_Homo sapiens_hsa053101.91117121
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87264533
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.81282838
24African trypanosomiasis_Homo sapiens_hsa051431.78662590
25Lysosome_Homo sapiens_hsa041421.76808305
26Toxoplasmosis_Homo sapiens_hsa051451.68410075
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65046329
28Salmonella infection_Homo sapiens_hsa051321.63060657
29Type I diabetes mellitus_Homo sapiens_hsa049401.61046552
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.60321246
31Phagosome_Homo sapiens_hsa041451.57277067
32Herpes simplex infection_Homo sapiens_hsa051681.50259552
33Chemokine signaling pathway_Homo sapiens_hsa040621.50156084
34Hematopoietic cell lineage_Homo sapiens_hsa046401.48393074
35Other glycan degradation_Homo sapiens_hsa005111.48357494
36Alcoholism_Homo sapiens_hsa050341.47807678
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.42378530
38Apoptosis_Homo sapiens_hsa042101.40158328
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34106779
40Shigellosis_Homo sapiens_hsa051311.33475892
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31154869
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27066802
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.25614493
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.23890914
45Viral myocarditis_Homo sapiens_hsa054161.20207095
46Antigen processing and presentation_Homo sapiens_hsa046121.18629617
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14244695
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13269529
49Hepatitis C_Homo sapiens_hsa051601.03233691
50Hepatitis B_Homo sapiens_hsa051611.01840762
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96187956
52Primary immunodeficiency_Homo sapiens_hsa053400.93169787
53Autoimmune thyroid disease_Homo sapiens_hsa053200.90868355
54Amoebiasis_Homo sapiens_hsa051460.90015780
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84340460
56Caffeine metabolism_Homo sapiens_hsa002320.82404182
57Acute myeloid leukemia_Homo sapiens_hsa052210.77904820
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76115141
59Platelet activation_Homo sapiens_hsa046110.75863416
60Complement and coagulation cascades_Homo sapiens_hsa046100.74520874
61T cell receptor signaling pathway_Homo sapiens_hsa046600.68885104
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68787909
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68425791
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.67841232
65Chronic myeloid leukemia_Homo sapiens_hsa052200.66277535
66HIF-1 signaling pathway_Homo sapiens_hsa040660.64487258
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.64236327
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63227622
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62666710
70Epstein-Barr virus infection_Homo sapiens_hsa051690.62664614
71Prion diseases_Homo sapiens_hsa050200.61305912
72Type II diabetes mellitus_Homo sapiens_hsa049300.57292213
73Prolactin signaling pathway_Homo sapiens_hsa049170.53050985
74Non-small cell lung cancer_Homo sapiens_hsa052230.52131240
75Pancreatic cancer_Homo sapiens_hsa052120.50021910
76Insulin resistance_Homo sapiens_hsa049310.48211516
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44339107
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.43641659
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43209423
80Endocytosis_Homo sapiens_hsa041440.42495563
81VEGF signaling pathway_Homo sapiens_hsa043700.42000206
82Small cell lung cancer_Homo sapiens_hsa052220.41588608
83Collecting duct acid secretion_Homo sapiens_hsa049660.34920878
84Pentose phosphate pathway_Homo sapiens_hsa000300.34547238
85Viral carcinogenesis_Homo sapiens_hsa052030.34427325
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32753516
87Vitamin digestion and absorption_Homo sapiens_hsa049770.30815425
88HTLV-I infection_Homo sapiens_hsa051660.29986788
89Fructose and mannose metabolism_Homo sapiens_hsa000510.28368336
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28209585
91p53 signaling pathway_Homo sapiens_hsa041150.27880647
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26375147
93Notch signaling pathway_Homo sapiens_hsa043300.26327396
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23403836
95Proteoglycans in cancer_Homo sapiens_hsa052050.23030864
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22433004
97ABC transporters_Homo sapiens_hsa020100.22379402
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21192021
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21019126
100Prostate cancer_Homo sapiens_hsa052150.20925638
101FoxO signaling pathway_Homo sapiens_hsa040680.20698327
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20468604
103Dorso-ventral axis formation_Homo sapiens_hsa043200.20139321
104Colorectal cancer_Homo sapiens_hsa052100.19235502
105GnRH signaling pathway_Homo sapiens_hsa049120.18480633
106Focal adhesion_Homo sapiens_hsa045100.17231578
107Bladder cancer_Homo sapiens_hsa052190.16182550
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.15492256
109Adherens junction_Homo sapiens_hsa045200.15121231
110Inositol phosphate metabolism_Homo sapiens_hsa005620.14625130
111MAPK signaling pathway_Homo sapiens_hsa040100.13901798
112Renal cell carcinoma_Homo sapiens_hsa052110.12852335
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.11799857
114Endometrial cancer_Homo sapiens_hsa052130.10268751
115DNA replication_Homo sapiens_hsa030300.07995125
116mTOR signaling pathway_Homo sapiens_hsa041500.06168505
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05218800
118Renin-angiotensin system_Homo sapiens_hsa046140.02866167

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