PIKFYVE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.24179980
2monoubiquitinated protein deubiquitination (GO:0035520)4.70236019
3nuclear pore organization (GO:0006999)4.51349299
4cell wall macromolecule catabolic process (GO:0016998)4.18234664
5positive regulation of cellular amide metabolic process (GO:0034250)4.08848924
6B cell receptor signaling pathway (GO:0050853)3.95818280
7cellular response to ethanol (GO:0071361)3.95430701
8pore complex assembly (GO:0046931)3.86305198
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80191936
10positive regulation of granulocyte differentiation (GO:0030854)3.79442824
11negative regulation of translation, ncRNA-mediated (GO:0040033)3.74416905
12regulation of translation, ncRNA-mediated (GO:0045974)3.74416905
13negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.74416905
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72698409
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.72698409
16modulation by symbiont of host immune response (GO:0052553)3.72698409
17positive regulation by symbiont of host defense response (GO:0052509)3.72698409
18modulation by symbiont of host defense response (GO:0052031)3.72698409
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72698409
20histone H3-K4 trimethylation (GO:0080182)3.69656632
21cellular extravasation (GO:0045123)3.68201254
22G-protein coupled receptor internalization (GO:0002031)3.62114248
23histone H3-K36 demethylation (GO:0070544)3.51125879
24regulation of histone H3-K27 methylation (GO:0061085)3.49274375
25definitive hemopoiesis (GO:0060216)3.42577787
26regulation of RNA export from nucleus (GO:0046831)3.36899483
27regulation of gamma-delta T cell activation (GO:0046643)3.34878641
28regulation of gamma-delta T cell differentiation (GO:0045586)3.32804405
29superoxide anion generation (GO:0042554)3.27327667
30negative regulation of granulocyte differentiation (GO:0030853)3.21158336
31melanin biosynthetic process (GO:0042438)3.20224187
32negative thymic T cell selection (GO:0045060)3.17482018
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.16852988
34negative regulation of DNA repair (GO:0045738)3.16247078
35cell wall macromolecule metabolic process (GO:0044036)3.15816747
36histone demethylation (GO:0016577)3.11087643
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.10079433
38response to host immune response (GO:0052572)3.10079433
39regulation of histone H3-K9 methylation (GO:0051570)3.09570900
40positive regulation of B cell differentiation (GO:0045579)3.08425361
41I-kappaB phosphorylation (GO:0007252)3.08129262
42pre-miRNA processing (GO:0031054)3.06406130
43melanin metabolic process (GO:0006582)3.05593861
44negative T cell selection (GO:0043383)3.04437790
45histone H3-K9 demethylation (GO:0033169)3.04398816
46positive T cell selection (GO:0043368)3.02645528
47negative regulation of erythrocyte differentiation (GO:0045647)2.97712455
48mitotic sister chromatid cohesion (GO:0007064)2.96390726
49developmental pigmentation (GO:0048066)2.93502205
50regulation of MHC class II biosynthetic process (GO:0045346)2.93047553
51regulation of nucleobase-containing compound transport (GO:0032239)2.87116100
52positive regulation of interleukin-1 beta secretion (GO:0050718)2.83311263
53lipid translocation (GO:0034204)2.82146021
54phospholipid translocation (GO:0045332)2.82146021
55histone H3-K4 methylation (GO:0051568)2.80894500
56peptidyl-lysine methylation (GO:0018022)2.79848912
57positive regulation of developmental pigmentation (GO:0048087)2.78992755
58N-terminal protein amino acid acetylation (GO:0006474)2.78952493
59embryonic process involved in female pregnancy (GO:0060136)2.77774783
60regulation of DNA endoreduplication (GO:0032875)2.77706457
61Golgi to endosome transport (GO:0006895)2.77008082
62secondary metabolite biosynthetic process (GO:0044550)2.76249249
63positive regulation of Rap GTPase activity (GO:0032854)2.73473418
64regulation of B cell differentiation (GO:0045577)2.73282481
65negative regulation of fibroblast apoptotic process (GO:2000270)2.73145539
66regulation of Rap GTPase activity (GO:0032317)2.69700373
67histone lysine methylation (GO:0034968)2.69475635
68microglial cell activation (GO:0001774)2.68802730
69detection of molecule of bacterial origin (GO:0032490)2.67888442
70response to host (GO:0075136)2.66335861
71response to host defenses (GO:0052200)2.66335861
72response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66335861
73protein dealkylation (GO:0008214)2.66026549
74protein demethylation (GO:0006482)2.66026549
75negative regulation of histone methylation (GO:0031061)2.65315359
76B cell proliferation (GO:0042100)2.64687201
77negative regulation of neurotransmitter secretion (GO:0046929)2.62063646
78dosage compensation (GO:0007549)2.62019881
79establishment of protein localization to Golgi (GO:0072600)2.61945749
80labyrinthine layer development (GO:0060711)2.61853063
81positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.61472588
82nucleus localization (GO:0051647)2.60243205
83regulation of germinal center formation (GO:0002634)2.59666911
84retrograde transport, vesicle recycling within Golgi (GO:0000301)2.59620551
85histone H3-K9 modification (GO:0061647)2.59416988
86peptidyl-threonine phosphorylation (GO:0018107)2.57972536
87positive thymic T cell selection (GO:0045059)2.57644923
88histone mRNA catabolic process (GO:0071044)2.57168251
89positive regulation of interleukin-1 secretion (GO:0050716)2.56431465
90positive regulation of gamma-delta T cell activation (GO:0046645)2.54741033
91T cell migration (GO:0072678)2.54595155
92positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.54386822
93protein targeting to Golgi (GO:0000042)2.54382333
94regulation of pigment cell differentiation (GO:0050932)2.54082173
95positive regulation of interferon-alpha production (GO:0032727)2.53664189
96interkinetic nuclear migration (GO:0022027)2.52137405
97regulation of interleukin-1 beta secretion (GO:0050706)2.51639434
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50285823
99negative regulation of cell killing (GO:0031342)2.50285823
100germinal center formation (GO:0002467)2.50040583
101regulation of interferon-beta biosynthetic process (GO:0045357)2.48458928
102ganglion development (GO:0061548)2.47874318
103response to UV-C (GO:0010225)2.47316738
104T cell selection (GO:0045058)2.46894620
105regulation of activation of Janus kinase activity (GO:0010533)2.46803946
106prostate gland growth (GO:0060736)2.45765861
107positive regulation of histone H3-K4 methylation (GO:0051571)2.45727890
108response to interleukin-15 (GO:0070672)2.45710168
109regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45614876
110positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.45317235
111regulation of histone methylation (GO:0031060)2.45041438
112positive regulation of DNA-templated transcription, initiation (GO:2000144)2.44486771
113macrophage activation involved in immune response (GO:0002281)2.44217362
114regulation of Rac protein signal transduction (GO:0035020)2.41791029
115regulation of protein polyubiquitination (GO:1902914)2.41485531
116protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.40533953
117regulation of fibroblast apoptotic process (GO:2000269)2.40486384
118regulation of NIK/NF-kappaB signaling (GO:1901222)2.40337186
119peptidyl-threonine modification (GO:0018210)2.40266576
120iron ion import (GO:0097286)2.40224699
121histone H4-K16 acetylation (GO:0043984)2.39190889
122hepatocyte apoptotic process (GO:0097284)2.38492765
123regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.38137638
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.37726649
125regulation of interferon-alpha production (GO:0032647)2.37475460
126regulation of granulocyte differentiation (GO:0030852)2.36561165
127DNA strand renaturation (GO:0000733)2.35864926
128import into cell (GO:0098657)2.35213302
129regulation of platelet aggregation (GO:0090330)2.34966594
130detection of other organism (GO:0098543)2.34675227
131response to muramyl dipeptide (GO:0032495)2.33561989
132muscle atrophy (GO:0014889)2.32712570
133presynaptic membrane assembly (GO:0097105)2.32453806
134response to lipoprotein particle (GO:0055094)2.32232897
135peptidyl-lysine trimethylation (GO:0018023)2.32073072
136positive regulation of interleukin-1 beta production (GO:0032731)2.31960177
137neutrophil activation (GO:0042119)2.31533316
138negative regulation of histone modification (GO:0031057)2.31392591
139positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.31213305
140negative regulation of mast cell activation (GO:0033004)2.30860982
141T cell homeostasis (GO:0043029)2.30617573
142microtubule anchoring (GO:0034453)2.30359634
143* phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.29306733
144regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28753252
145B cell homeostasis (GO:0001782)2.28329988
146mitochondrion distribution (GO:0048311)2.27895533
147protein K11-linked deubiquitination (GO:0035871)2.26692076
148positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.26651361
149regulation of histone H3-K4 methylation (GO:0051569)2.26137160
150negative regulation of homotypic cell-cell adhesion (GO:0034111)2.25428942
151neutrophil mediated immunity (GO:0002446)2.25040159
152L-amino acid import (GO:0043092)2.23180494
153pigmentation (GO:0043473)2.22802749
154positive regulation of heat generation (GO:0031652)2.22000001
155regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.21655792
156regulation of timing of cell differentiation (GO:0048505)2.18980990
157auditory receptor cell differentiation (GO:0042491)2.18331815
158positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.17902686
159macroautophagy (GO:0016236)2.17173704
160regulation of B cell receptor signaling pathway (GO:0050855)2.14914445
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14423142
162histone H3-K9 methylation (GO:0051567)2.14414155
163modulation by symbiont of host cellular process (GO:0044068)2.13922255
164replicative senescence (GO:0090399)2.13667365
165phosphatidylinositol dephosphorylation (GO:0046856)2.13016903
166positive regulation of interleukin-1 production (GO:0032732)2.12033260
167early endosome to late endosome transport (GO:0045022)2.11499966
168female gonad development (GO:0008585)2.11392880
169histone lysine demethylation (GO:0070076)2.10837495
170regulation of interleukin-1 secretion (GO:0050704)2.10501199
171neutrophil activation involved in immune response (GO:0002283)2.09797962
172positive regulation of antigen processing and presentation (GO:0002579)2.09674146
173cerebellar Purkinje cell differentiation (GO:0021702)2.09609000
174response to peptidoglycan (GO:0032494)2.08160787
175granulocyte activation (GO:0036230)2.08137712
176mesenchymal cell differentiation (GO:0048762)2.06248406
177positive regulation of defense response to virus by host (GO:0002230)2.05961854
178CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.05205876
179T-helper cell differentiation (GO:0042093)2.05205876
180detection of bacterium (GO:0016045)2.02992294
181regulation of establishment of cell polarity (GO:2000114)2.02912525
182cytoplasmic mRNA processing body assembly (GO:0033962)2.02818363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.67468631
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.49315134
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53517360
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45469341
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44909969
6E2F7_22180533_ChIP-Seq_HELA_Human2.36360437
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.35477189
8* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.34583586
9RUNX_20019798_ChIP-Seq_JUKART_Human2.32167109
10* FLI1_27457419_Chip-Seq_LIVER_Mouse2.25993509
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23129283
12GATA1_22025678_ChIP-Seq_K562_Human2.22237274
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.21904718
14* PCGF2_27294783_Chip-Seq_NPCs_Mouse2.18568910
15* SUZ12_27294783_Chip-Seq_NPCs_Mouse2.15385442
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.14308490
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13309022
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11547992
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.09423817
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09417709
21* NFE2_27457419_Chip-Seq_LIVER_Mouse2.06794587
22SCL_19346495_ChIP-Seq_HPC-7_Human2.06041180
23* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04600817
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.01202671
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.00079529
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99915267
27* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.93335218
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88576640
29* EZH2_27294783_Chip-Seq_NPCs_Mouse1.88143824
30* NANOG_18555785_Chip-Seq_ESCs_Mouse1.87575566
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.84687558
32* E2F1_18555785_Chip-Seq_ESCs_Mouse1.84393193
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82705289
34IGF1R_20145208_ChIP-Seq_DFB_Human1.82272795
35EZH2_22144423_ChIP-Seq_EOC_Human1.82048365
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.81640292
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81477672
38* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.76898336
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76216232
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75322778
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75302864
42MYB_26560356_Chip-Seq_TH2_Human1.75258565
43* P53_22387025_ChIP-Seq_ESCs_Mouse1.73081185
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72689312
45* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70154645
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69791341
47* P300_19829295_ChIP-Seq_ESCs_Human1.66004862
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65442721
49* CMYC_18555785_Chip-Seq_ESCs_Mouse1.65400074
50* STAT3_18555785_Chip-Seq_ESCs_Mouse1.63226715
51SMAD4_21799915_ChIP-Seq_A2780_Human1.62280162
52STAT3_23295773_ChIP-Seq_U87_Human1.59181050
53VDR_24787735_ChIP-Seq_THP-1_Human1.58530848
54* NMYC_18555785_Chip-Seq_ESCs_Mouse1.58454164
55* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56904350
56* P300_18555785_Chip-Seq_ESCs_Mouse1.56839544
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55899200
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.54715515
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.52292361
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50973423
61* OCT4_18555785_Chip-Seq_ESCs_Mouse1.50722207
62* SOX2_18555785_Chip-Seq_ESCs_Mouse1.49425047
63MYB_26560356_Chip-Seq_TH1_Human1.49103446
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46424858
65* PU1_27457419_Chip-Seq_LIVER_Mouse1.45989996
66* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.45578620
67* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45027461
68MYC_22102868_ChIP-Seq_BL_Human1.41594953
69* TCF4_23295773_ChIP-Seq_U87_Human1.40207326
70* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.40180675
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39993367
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39663246
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38749811
74AHR_22903824_ChIP-Seq_MCF-7_Human1.38137052
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.37528863
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37411126
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37411126
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.37087144
79ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36963570
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.35952698
81TP53_16413492_ChIP-PET_HCT116_Human1.35700977
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.35676641
83* KLF4_18555785_Chip-Seq_ESCs_Mouse1.34849529
84* ZFX_18555785_Chip-Seq_ESCs_Mouse1.34833799
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.34266846
86* CTCF_18555785_Chip-Seq_ESCs_Mouse1.32379290
87TP53_18474530_ChIP-ChIP_U2OS_Human1.31833450
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31725274
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30927390
90FUS_26573619_Chip-Seq_HEK293_Human1.30298288
91GATA3_27048872_Chip-Seq_THYMUS_Human1.30217201
92TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29118709
93ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28018385
94TAF15_26573619_Chip-Seq_HEK293_Human1.27853277
95* CRX_20693478_ChIP-Seq_RETINA_Mouse1.27332428
96* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.26912879
97EWS_26573619_Chip-Seq_HEK293_Human1.26238472
98DROSHA_22980978_ChIP-Seq_HELA_Human1.26116330
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25039775
100ER_23166858_ChIP-Seq_MCF-7_Human1.23857599
101* PU_27001747_Chip-Seq_BMDM_Mouse1.23271580
102* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17437263
103SPI1_23127762_ChIP-Seq_K562_Human1.17436530
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16797770
105AR_25329375_ChIP-Seq_VCAP_Human1.16546406
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16092301
107RUNX2_22187159_ChIP-Seq_PCA_Human1.15786586
108AR_21572438_ChIP-Seq_LNCaP_Human1.15382078
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13999670
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13999607
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13894933
112SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13453412
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13105970
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12907949
115FOXO3_23340844_ChIP-Seq_DLD1_Human1.12311521
116GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12160192
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11797497
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10744822
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10332123
120KDM2B_26808549_Chip-Seq_REH_Human1.10090158
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09827401
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.09638941
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.09170264
124* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08978294
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08185867
126PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08063159
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07910634
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07695348
129CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05750453
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05421764
131RNF2_27304074_Chip-Seq_NSC_Mouse1.04639338
132SPI1_23547873_ChIP-Seq_NB4_Human1.04197889
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04185625
134CBX2_27304074_Chip-Seq_ESCs_Mouse1.03782109
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03549093
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02609204
137BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02507934
138TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01638793
139JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01183077
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01089414
141BRD4_25478319_ChIP-Seq_HGPS_Human0.99978004
142GATA2_19941826_ChIP-Seq_K562_Human0.99915249
143FOXA2_19822575_ChIP-Seq_HepG2_Human0.98676748
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97359795
145TCF7_22412390_ChIP-Seq_EML_Mouse0.95952092
146* GATA3_26560356_Chip-Seq_TH2_Human0.95455661
147FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94304539
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93806290
149VDR_24763502_ChIP-Seq_THP-1_Human0.91324612

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.18919763
2MP0000015_abnormal_ear_pigmentation4.29604280
3MP0003136_yellow_coat_color3.85737206
4MP0005171_absent_coat_pigmentation3.43649776
5MP0005174_abnormal_tail_pigmentation3.41663634
6MP0001188_hyperpigmentation2.87846583
7MP0003763_abnormal_thymus_physiology2.57041881
8MP0000372_irregular_coat_pigmentation2.45831318
9MP0005409_darkened_coat_color2.44045234
10MP0002009_preneoplasia2.43820754
11MP0003787_abnormal_imprinting2.36932360
12MP0004808_abnormal_hematopoietic_stem2.33301994
13MP0000566_synostosis2.32276700
14MP0004381_abnormal_hair_follicle2.32195769
15MP0005257_abnormal_intraocular_pressure2.31486044
16MP0006292_abnormal_olfactory_placode2.22782196
17MP0003303_peritoneal_inflammation2.19610857
18MP0010352_gastrointestinal_tract_polyps2.13828099
19MP0000371_diluted_coat_color2.12014534
20MP0002095_abnormal_skin_pigmentation2.10293512
21MP0003656_abnormal_erythrocyte_physiolo2.05121630
22MP0005076_abnormal_cell_differentiation1.94577158
23MP0002102_abnormal_ear_morphology1.88984818
24MP0003890_abnormal_embryonic-extraembry1.88489065
25MP0001835_abnormal_antigen_presentation1.86911656
26MP0002398_abnormal_bone_marrow1.82887236
27MP0000685_abnormal_immune_system1.82807555
28MP0000703_abnormal_thymus_morphology1.77117405
29MP0000383_abnormal_hair_follicle1.70096900
30MP0005645_abnormal_hypothalamus_physiol1.68785024
31MP0005451_abnormal_body_composition1.63312615
32MP0009697_abnormal_copulation1.62290439
33MP0003045_fibrosis1.58322549
34MP0005464_abnormal_platelet_physiology1.53788266
35MP0000689_abnormal_spleen_morphology1.53236848
36MP0003183_abnormal_peptide_metabolism1.49482807
37MP0002277_abnormal_respiratory_mucosa1.49452003
38MP0003828_pulmonary_edema1.47478924
39MP0001545_abnormal_hematopoietic_system1.46825248
40MP0005397_hematopoietic_system_phenotyp1.46825248
41MP0002166_altered_tumor_susceptibility1.46509198
42MP0000716_abnormal_immune_system1.45680404
43MP0005387_immune_system_phenotype1.45506441
44MP0001790_abnormal_immune_system1.45506441
45MP0002722_abnormal_immune_system1.44385371
46MP0002006_tumorigenesis1.40757701
47MP0001186_pigmentation_phenotype1.38483097
48MP0001915_intracranial_hemorrhage1.38038056
49MP0002075_abnormal_coat/hair_pigmentati1.37107528
50MP0002877_abnormal_melanocyte_morpholog1.34623153
51MP0003724_increased_susceptibility_to1.32261408
52MP0002177_abnormal_outer_ear1.30745547
53MP0003221_abnormal_cardiomyocyte_apopto1.25887026
54MP0001986_abnormal_taste_sensitivity1.22465732
55MP0002419_abnormal_innate_immunity1.22035085
56MP0003868_abnormal_feces_composition1.21183650
57MP0002928_abnormal_bile_duct1.20582649
58MP0005379_endocrine/exocrine_gland_phen1.20039192
59MP0001324_abnormal_eye_pigmentation1.19957076
60MP0009115_abnormal_fat_cell1.18436475
61MP0002429_abnormal_blood_cell1.17965416
62MP0002405_respiratory_system_inflammati1.17428016
63MP0000427_abnormal_hair_cycle1.16798801
64MP0010307_abnormal_tumor_latency1.15813516
65MP0005646_abnormal_pituitary_gland1.15122902
66MP0001800_abnormal_humoral_immune1.14702013
67MP0010678_abnormal_skin_adnexa1.13838817
68MP0008058_abnormal_DNA_repair1.13528773
69MP0008057_abnormal_DNA_replication1.12531474
70MP0010094_abnormal_chromosome_stability1.12297581
71MP0008260_abnormal_autophagy1.11252268
72MP0005621_abnormal_cell_physiology1.10432135
73MP0003172_abnormal_lysosome_physiology1.10030144
74MP0002638_abnormal_pupillary_reflex1.09766524
75MP0004947_skin_inflammation1.06489145
76MP0002452_abnormal_antigen_presenting1.06087697
77MP0004742_abnormal_vestibular_system1.06074560
78MP0002086_abnormal_extraembryonic_tissu1.05150502
79MP0009278_abnormal_bone_marrow1.04620946
80MP0005647_abnormal_sex_gland1.02546435
81MP0002148_abnormal_hypersensitivity_rea1.02514757
82MP0003941_abnormal_skin_development1.01279303
83MP0002998_abnormal_bone_remodeling1.01196579
84MP0002254_reproductive_system_inflammat1.00725040
85MP0002088_abnormal_embryonic_growth/wei0.96873003
86MP0003984_embryonic_growth_retardation0.96291363
87MP0005075_abnormal_melanosome_morpholog0.94804626
88MP0002876_abnormal_thyroid_physiology0.94631405
89MP0008961_abnormal_basal_metabolism0.94524147
90MP0002723_abnormal_immune_serum0.93171939
91MP0000579_abnormal_nail_morphology0.92601291
92MP0005000_abnormal_immune_tolerance0.91155663
93MP0003077_abnormal_cell_cycle0.90464321
94MP0001851_eye_inflammation0.90104800
95MP0005671_abnormal_response_to0.89275370
96MP0009703_decreased_birth_body0.86765388
97MP0002168_other_aberrant_phenotype0.86154779
98MP0010234_abnormal_vibrissa_follicle0.86133973
99MP0003091_abnormal_cell_migration0.85886639
100MP0005380_embryogenesis_phenotype0.85312413
101MP0001672_abnormal_embryogenesis/_devel0.85312413
102MP0002138_abnormal_hepatobiliary_system0.84764789
103MP0001730_embryonic_growth_arrest0.84441091
104MP0000350_abnormal_cell_proliferation0.84230861
105MP0009046_muscle_twitch0.84113424
106MP0001486_abnormal_startle_reflex0.82981028
107MP0005248_abnormal_Harderian_gland0.82522331
108MP0006054_spinal_hemorrhage0.79987567
109MP0005384_cellular_phenotype0.79701245
110MP0000428_abnormal_craniofacial_morphol0.78700392
111MP0003436_decreased_susceptibility_to0.77564204
112MP0008877_abnormal_DNA_methylation0.77550740
113MP0010386_abnormal_urinary_bladder0.77536760
114MP0003938_abnormal_ear_development0.77469893
115MP0000465_gastrointestinal_hemorrhage0.76089493
116MP0001819_abnormal_immune_cell0.75828913
117MP0005025_abnormal_response_to0.75607775
118MP0002019_abnormal_tumor_incidence0.74756488
119MP0005408_hypopigmentation0.73997719
120MP0002420_abnormal_adaptive_immunity0.73896912
121MP0003111_abnormal_nucleus_morphology0.73765590
122MP0003567_abnormal_fetal_cardiomyocyte0.73591785
123MP0000778_abnormal_nervous_system0.73478221
124MP0004134_abnormal_chest_morphology0.73103914
125MP0002938_white_spotting0.72295059
126MP0003943_abnormal_hepatobiliary_system0.72131488
127MP0003121_genomic_imprinting0.72093141
128MP0003632_abnormal_nervous_system0.71364885
129MP0004883_abnormal_blood_vessel0.71232462
130MP0002925_abnormal_cardiovascular_devel0.70930044
131MP0002396_abnormal_hematopoietic_system0.70852201
132MP0003448_altered_tumor_morphology0.70715115
133MP0004130_abnormal_muscle_cell0.70464298
134MP0001346_abnormal_lacrimal_gland0.69092774
135MP0005220_abnormal_exocrine_pancreas0.68275729
136MP0005310_abnormal_salivary_gland0.67096484
137MP0004185_abnormal_adipocyte_glucose0.66581884
138MP0003300_gastrointestinal_ulcer0.65879163
139MP0000432_abnormal_head_morphology0.65748405
140MP0004510_myositis0.65557222
141MP0009780_abnormal_chondrocyte_physiolo0.65452590
142MP0009764_decreased_sensitivity_to0.65329783
143MP0005197_abnormal_uvea_morphology0.65232357
144MP0003937_abnormal_limbs/digits/tail_de0.64524305
145MP0001984_abnormal_olfaction0.63379888
146MP0000470_abnormal_stomach_morphology0.61604304
147MP0001177_atelectasis0.60544260
148MP0000026_abnormal_inner_ear0.59807712
149MP0001502_abnormal_circadian_rhythm0.59174191
150MP0003690_abnormal_glial_cell0.58619351
151MP0001661_extended_life_span0.56958578
152MP0009785_altered_susceptibility_to0.55725396
153MP0000627_abnormal_mammary_gland0.55270375
154MP0002109_abnormal_limb_morphology0.55058681
155MP0005503_abnormal_tendon_morphology0.54690902
156MP0005394_taste/olfaction_phenotype0.53097002
157MP0005499_abnormal_olfactory_system0.53097002
158MP0002163_abnormal_gland_morphology0.52564988
159MP0001191_abnormal_skin_condition0.51815293

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.84736584
2Chromsome breakage (HP:0040012)4.41538364
3Prostate neoplasm (HP:0100787)3.82992904
4T lymphocytopenia (HP:0005403)3.46358767
5Acute myeloid leukemia (HP:0004808)3.36818008
6Abnormality of DNA repair (HP:0003254)3.36445209
7Panhypogammaglobulinemia (HP:0003139)3.29637963
8Febrile seizures (HP:0002373)3.14310434
9Abnormality of T cell number (HP:0011839)3.10463538
10Aplasia/Hypoplasia of the macula (HP:0008059)3.06206343
11Recurrent viral infections (HP:0004429)3.01716071
12Abnormality of the nasal septum (HP:0000419)3.00877375
13Hypoplasia of the fovea (HP:0007750)2.98011467
14Aplasia/Hypoplasia of the fovea (HP:0008060)2.98011467
15Abnormality of the fingertips (HP:0001211)2.93839156
16Viral hepatitis (HP:0006562)2.89549542
17Osteomalacia (HP:0002749)2.85633492
18Subacute progressive viral hepatitis (HP:0006572)2.82031127
19Abnormality of the renal collecting system (HP:0004742)2.72324775
20Acute lymphatic leukemia (HP:0006721)2.71130461
21Absent frontal sinuses (HP:0002688)2.69859851
22Gingivitis (HP:0000230)2.69787750
23Lip pit (HP:0100267)2.63674822
24Thyroiditis (HP:0100646)2.63129222
25Ectopic kidney (HP:0000086)2.61616549
26Periodontitis (HP:0000704)2.58817333
27Duplicated collecting system (HP:0000081)2.58092743
28Aplasia/Hypoplasia affecting the retina (HP:0008061)2.57376359
29Abnormality of B cell number (HP:0010975)2.54866635
30B lymphocytopenia (HP:0010976)2.54528390
31Thyroid carcinoma (HP:0002890)2.54477729
32Hypoplasia of the thymus (HP:0000778)2.51292660
33Blue irides (HP:0000635)2.47265614
34Upper limb muscle weakness (HP:0003484)2.47218939
35Submucous cleft hard palate (HP:0000176)2.45302673
36Recurrent abscess formation (HP:0002722)2.44216446
37Abnormality of incisor morphology (HP:0011063)2.43649658
38Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41912458
39Spontaneous hematomas (HP:0007420)2.39341232
40Abnormality of the fovea (HP:0000493)2.35377328
41Autoimmune hemolytic anemia (HP:0001890)2.35242565
42Recurrent bacterial skin infections (HP:0005406)2.34191707
43Transitional cell carcinoma of the bladder (HP:0006740)2.23959334
44Heterotopia (HP:0002282)2.23069361
45Severe combined immunodeficiency (HP:0004430)2.22748712
46Chronic hepatic failure (HP:0100626)2.22122649
47Hematochezia (HP:0002573)2.21421882
48Meningitis (HP:0001287)2.20102885
49Osteomyelitis (HP:0002754)2.18652671
50Volvulus (HP:0002580)2.17857029
51Bladder carcinoma (HP:0002862)2.17708402
52Bladder neoplasm (HP:0009725)2.17708402
53Retrobulbar optic neuritis (HP:0100654)2.16053210
54Optic neuritis (HP:0100653)2.16053210
55Distal lower limb amyotrophy (HP:0008944)2.15551281
56Sandal gap (HP:0001852)2.15278567
57Neonatal hypoglycemia (HP:0001998)2.15245553
58Clubbing of toes (HP:0100760)2.15164447
59Prominent nose (HP:0000448)2.13342191
60Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.12813240
61Dysmetric saccades (HP:0000641)2.12705941
62Overlapping toe (HP:0001845)2.11371431
63Generalized hypopigmentation (HP:0007513)2.11334767
64Generalized hypopigmentation of hair (HP:0011358)2.09982634
65Ocular albinism (HP:0001107)2.06983934
66Diastasis recti (HP:0001540)2.06857037
67Truncal obesity (HP:0001956)2.06105033
68Syringomyelia (HP:0003396)2.05755572
69Combined immunodeficiency (HP:0005387)2.05522245
70Abnormality of oral frenula (HP:0000190)2.04716336
71Aplasia/Hypoplasia of the uvula (HP:0010293)2.04608645
72Eosinophilia (HP:0001880)2.03613192
73Abnormality of the frontal sinuses (HP:0002687)2.01173849
74Ankyloglossia (HP:0010296)2.00676371
75Nephroblastoma (Wilms tumor) (HP:0002667)1.98298173
76Chronic mucocutaneous candidiasis (HP:0002728)1.96436899
77Recurrent cutaneous fungal infections (HP:0011370)1.96436899
78Cheilitis (HP:0100825)1.96095773
79Cellulitis (HP:0100658)1.95912830
80Tubulointerstitial nephritis (HP:0001970)1.95563932
81Low anterior hairline (HP:0000294)1.95338219
82Abnormality of chromosome stability (HP:0003220)1.95069428
83Eczematoid dermatitis (HP:0000976)1.94449765
84Alveolar cell carcinoma (HP:0006519)1.94305912
85Cubitus valgus (HP:0002967)1.93256561
86Abnormality of T cells (HP:0002843)1.91859678
87Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90789598
88Tetany (HP:0001281)1.90026034
89Congenital sensorineural hearing impairment (HP:0008527)1.89560664
90Curly hair (HP:0002212)1.89556230
91Embryonal renal neoplasm (HP:0011794)1.89513364
92Difficulty running (HP:0009046)1.89012620
93Granulocytopenia (HP:0001913)1.87471071
94Gastrointestinal inflammation (HP:0004386)1.86441593
95Neoplasm of the tracheobronchial system (HP:0100552)1.85964443
96Rhabdomyosarcoma (HP:0002859)1.85553047
97Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84800265
98Hepatoblastoma (HP:0002884)1.84584139
99Papilledema (HP:0001085)1.83694206
100Urethral obstruction (HP:0000796)1.83048932
101Gastrointestinal carcinoma (HP:0002672)1.82951096
102Malignant gastrointestinal tract tumors (HP:0006749)1.82951096
103Relative macrocephaly (HP:0004482)1.82289833
104Fatigue (HP:0012378)1.82038987
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.81934097
106Abnormality of the prostate (HP:0008775)1.81848003
107Lower limb amyotrophy (HP:0007210)1.81606329
108Conjunctival telangiectasia (HP:0000524)1.81206651
109Basal cell carcinoma (HP:0002671)1.80940136
110Medulloblastoma (HP:0002885)1.78541979
111Colitis (HP:0002583)1.78404003
112Protruding tongue (HP:0010808)1.78084010
113Uterine leiomyosarcoma (HP:0002891)1.77953834
114Leiomyosarcoma (HP:0100243)1.77953834
115Abnormality of eosinophils (HP:0001879)1.77740336
116Chronic diarrhea (HP:0002028)1.75701901
117Thickened calvaria (HP:0002684)1.75512984
118Thickened helices (HP:0000391)1.75005695
119Long eyelashes (HP:0000527)1.74737980
120Abnormality of the left ventricular outflow tract (HP:0011103)1.74710100
121Subaortic stenosis (HP:0001682)1.74710100
122Leukocytosis (HP:0001974)1.74523125
123Overgrowth (HP:0001548)1.74308720
124Premature loss of primary teeth (HP:0006323)1.73631386
125Gingival bleeding (HP:0000225)1.73170612
126Abnormality of the columella (HP:0009929)1.72118665
127Fair hair (HP:0002286)1.71875002
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71555013
129Abnormality of the carotid arteries (HP:0005344)1.70691722
130Absent speech (HP:0001344)1.69979927
131Agammaglobulinemia (HP:0004432)1.69540179
132Septo-optic dysplasia (HP:0100842)1.68580042
133Anal stenosis (HP:0002025)1.68352631
134Cutis marmorata (HP:0000965)1.67682216
135Papillary thyroid carcinoma (HP:0002895)1.67266852
136Aplasia cutis congenita (HP:0001057)1.66997569
137Midline defect of the nose (HP:0004122)1.66043945
138Deep philtrum (HP:0002002)1.65560880
139Neoplasm of the adrenal cortex (HP:0100641)1.65382397
140Obsessive-compulsive behavior (HP:0000722)1.65151722
141White forelock (HP:0002211)1.65067568
142Thick nail (HP:0001805)1.64600688
143Iris hypopigmentation (HP:0007730)1.64547065
144Recurrent fungal infections (HP:0002841)1.64369578
145Prolonged bleeding time (HP:0003010)1.63584239
146Dislocated radial head (HP:0003083)1.63123653
147Lymphopenia (HP:0001888)1.62709504
148Autoimmune thrombocytopenia (HP:0001973)1.62107316
149Meckel diverticulum (HP:0002245)1.61942325
150Abnormality of the preputium (HP:0100587)1.61733998
151Macroorchidism (HP:0000053)1.60831008
152Mediastinal lymphadenopathy (HP:0100721)1.59773752
153Stomach cancer (HP:0012126)1.59029332
154Hypoplastic labia majora (HP:0000059)1.58990224
155Increased number of teeth (HP:0011069)1.58893188
156Gaze-evoked nystagmus (HP:0000640)1.58142454
157Hypoplasia of the iris (HP:0007676)1.57425089
158Abnormality of the ileum (HP:0001549)1.56831587
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.55919961
160Homocystinuria (HP:0002156)1.54678639
161Abnormality of homocysteine metabolism (HP:0010919)1.54678639
162Vasculitis (HP:0002633)1.54334283
163Long clavicles (HP:0000890)1.53788607
164Stomatitis (HP:0010280)1.53725822
165Drooling (HP:0002307)1.53350703
166Excessive salivation (HP:0003781)1.53350703
167Everted lower lip vermilion (HP:0000232)1.52965746
168Abnormal delayed hypersensitivity skin test (HP:0002963)1.52726645
169Recurrent pneumonia (HP:0006532)1.52070687
170Widely spaced teeth (HP:0000687)1.50597151
171Narrow palate (HP:0000189)1.50381465
172Abnormality of calcium-phosphate metabolism (HP:0100530)1.50178518
173Recurrent skin infections (HP:0001581)1.49875628
174Aqueductal stenosis (HP:0002410)1.49172363
175Pulmonary artery stenosis (HP:0004415)1.48797581
176Inflammation of the large intestine (HP:0002037)1.48755980
177Spinal cord lesions (HP:0100561)1.48522078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.06467472
2MAP3K142.93783180
3ZAK2.78845842
4INSRR2.55762382
5BRD42.29971456
6EIF2AK22.22131127
7IRAK32.21123840
8CAMK1D2.14689495
9SGK22.06364908
10MAP3K102.03867990
11CDK122.00749579
12FRK2.00157839
13RIPK41.92386313
14EEF2K1.87628701
15EIF2AK31.84846945
16NUAK11.83409338
17YES11.81041533
18IRAK41.77297979
19JAK11.76817914
20CAMK1G1.67364071
21LATS11.67045569
22NEK61.63571904
23PRPF4B1.56561655
24TXK1.53933374
25BMPR21.52756897
26MAP3K131.51224461
27AKT31.48023425
28IKBKE1.44212306
29KSR21.42317483
30SIK21.40861465
31JAK31.40658313
32SGK31.40128670
33ACVR1B1.37710795
34BTK1.36889578
35TNIK1.31975742
36MAP3K21.29737252
37IKBKB1.28401530
38PIK3CG1.28246288
39TAOK31.28012204
40MKNK21.21628161
41MAP4K11.21285413
42GRK11.20329981
43NTRK31.18936024
44BRSK21.18191666
45MELK1.13583410
46SGK2231.11825270
47SGK4941.11825270
48TYK21.09964501
49STK31.09565184
50SYK1.08903417
51MAP2K31.07079781
52RAF11.06793036
53CHUK1.05906615
54KSR11.05649517
55PIK3CA1.05500086
56SIK31.05097174
57MAP3K71.04802639
58MAP2K71.04354457
59PKN11.04174034
60CDK31.02660689
61FGFR31.02552778
62WNK11.01119969
63ITK0.96847691
64FGR0.95293505
65TEC0.92041585
66FGFR40.90780489
67BMPR1B0.89525840
68RET0.89500905
69CAMKK20.89441391
70MAP3K90.88983715
71TRPM70.88844361
72CDK90.86606312
73MAPK130.85388739
74PRKAA20.82049764
75MARK30.81416688
76MAPK70.80992745
77* SGK10.80703180
78HCK0.80007355
79ATR0.79067382
80JAK20.78779143
81PKN20.77880703
82SRPK10.77666935
83CLK10.74416401
84EPHA30.74330661
85MKNK10.73728084
86HIPK20.72014076
87KIT0.70787549
88ERBB30.68826359
89SIK10.68456442
90PDGFRA0.67329194
91IRAK10.65735350
92STK240.65036870
93MAP3K10.64895593
94ICK0.64696997
95PDK10.63883997
96MTOR0.63757326
97PNCK0.62818808
98FGFR20.62260284
99MST1R0.59749410
100ZAP700.59579084
101PRKCE0.58009642
102TNK20.56731028
103PRKD20.56605069
104TLK10.56126873
105ATM0.56126047
106PIM10.56044350
107MAPK110.54407910
108CDK40.53990710
109MAP3K60.51811468
110MAPK100.51259156
111CDC42BPA0.50847943
112CDK60.49832694
113ADRBK20.49608599
114FES0.49070008
115STK40.48693922
116CAMK40.48451569
117RPS6KB10.48233442
118LCK0.47460168
119TYRO30.47053444
120CSNK1D0.46920811
121CSF1R0.46801777
122BLK0.46763365
123LYN0.46240589
124PRKCQ0.45886435
125PDGFRB0.45739632
126ABL10.45117496
127MAPK140.44882006
128RPS6KB20.44631110
129* AKT10.44609553
130NEK90.44589012
131IRAK20.43755123
132CSNK1A1L0.43560178
133PLK20.43375828
134TBK10.42200858
135MARK20.41979021
136CSK0.41826264
137NLK0.41772672
138TAF10.40116282
139BRAF0.38844235
140STK110.38535326

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.12856721
2Non-small cell lung cancer_Homo sapiens_hsa052231.99104995
3Acute myeloid leukemia_Homo sapiens_hsa052211.62897810
4Allograft rejection_Homo sapiens_hsa053301.62282811
5Endometrial cancer_Homo sapiens_hsa052131.61843998
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58688236
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56777800
8Graft-versus-host disease_Homo sapiens_hsa053321.56720569
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.53111954
10Renal cell carcinoma_Homo sapiens_hsa052111.53038151
11Fanconi anemia pathway_Homo sapiens_hsa034601.52283203
12Measles_Homo sapiens_hsa051621.49497539
13Type II diabetes mellitus_Homo sapiens_hsa049301.45503908
14mTOR signaling pathway_Homo sapiens_hsa041501.41967002
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.40891561
16Non-homologous end-joining_Homo sapiens_hsa034501.39864218
17Colorectal cancer_Homo sapiens_hsa052101.39627766
18* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.39419443
19Osteoclast differentiation_Homo sapiens_hsa043801.38283879
20Platelet activation_Homo sapiens_hsa046111.37104353
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34363128
22Autoimmune thyroid disease_Homo sapiens_hsa053201.30728182
23Lysine degradation_Homo sapiens_hsa003101.29733108
24TNF signaling pathway_Homo sapiens_hsa046681.26325152
25Glioma_Homo sapiens_hsa052141.25585436
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.23101592
27Nicotine addiction_Homo sapiens_hsa050331.19588369
28Dorso-ventral axis formation_Homo sapiens_hsa043201.18964900
29Hematopoietic cell lineage_Homo sapiens_hsa046401.17887548
30Influenza A_Homo sapiens_hsa051641.17666543
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17290660
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16197424
33* Inositol phosphate metabolism_Homo sapiens_hsa005621.13285396
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13183301
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12686437
36Herpes simplex infection_Homo sapiens_hsa051681.11757850
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.11542053
38Morphine addiction_Homo sapiens_hsa050321.10153683
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09289790
40Leishmaniasis_Homo sapiens_hsa051401.09205323
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.09067756
42Sphingolipid metabolism_Homo sapiens_hsa006001.09016108
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08599397
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.08150635
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07510427
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06430340
47Long-term potentiation_Homo sapiens_hsa047201.06066226
48Asthma_Homo sapiens_hsa053101.05931765
49Malaria_Homo sapiens_hsa051441.05820333
50ABC transporters_Homo sapiens_hsa020101.05746926
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05734601
52Chemokine signaling pathway_Homo sapiens_hsa040621.05287110
53B cell receptor signaling pathway_Homo sapiens_hsa046621.01619339
54Systemic lupus erythematosus_Homo sapiens_hsa053221.01089739
55Type I diabetes mellitus_Homo sapiens_hsa049400.98236359
56VEGF signaling pathway_Homo sapiens_hsa043700.96728265
57Viral carcinogenesis_Homo sapiens_hsa052030.95969598
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.95868860
59Thyroid cancer_Homo sapiens_hsa052160.94676885
60Primary immunodeficiency_Homo sapiens_hsa053400.92549413
61Taste transduction_Homo sapiens_hsa047420.91646960
62Rheumatoid arthritis_Homo sapiens_hsa053230.91477474
63Staphylococcus aureus infection_Homo sapiens_hsa051500.91134773
64Tuberculosis_Homo sapiens_hsa051520.89904829
65mRNA surveillance pathway_Homo sapiens_hsa030150.89642091
66Estrogen signaling pathway_Homo sapiens_hsa049150.88445238
67Long-term depression_Homo sapiens_hsa047300.88443024
68Prostate cancer_Homo sapiens_hsa052150.87587060
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85666247
70Phototransduction_Homo sapiens_hsa047440.85176512
71MicroRNAs in cancer_Homo sapiens_hsa052060.84653325
72Ovarian steroidogenesis_Homo sapiens_hsa049130.84598851
73African trypanosomiasis_Homo sapiens_hsa051430.84214460
74GnRH signaling pathway_Homo sapiens_hsa049120.83421669
75Small cell lung cancer_Homo sapiens_hsa052220.82973172
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82597585
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.82346946
78HIF-1 signaling pathway_Homo sapiens_hsa040660.82283178
79Proteoglycans in cancer_Homo sapiens_hsa052050.82195749
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81760388
81Hepatitis C_Homo sapiens_hsa051600.81673365
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81523430
83Toxoplasmosis_Homo sapiens_hsa051450.77898889
84Insulin resistance_Homo sapiens_hsa049310.76993752
85Olfactory transduction_Homo sapiens_hsa047400.75522727
86Choline metabolism in cancer_Homo sapiens_hsa052310.74168212
87Glutamatergic synapse_Homo sapiens_hsa047240.73767093
88Vitamin digestion and absorption_Homo sapiens_hsa049770.73224056
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72989559
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72979867
91Melanoma_Homo sapiens_hsa052180.70233745
92Hepatitis B_Homo sapiens_hsa051610.68292462
93Insulin signaling pathway_Homo sapiens_hsa049100.67556816
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67264182
95cAMP signaling pathway_Homo sapiens_hsa040240.66682007
96FoxO signaling pathway_Homo sapiens_hsa040680.66041315
97Calcium signaling pathway_Homo sapiens_hsa040200.65421522
98Prolactin signaling pathway_Homo sapiens_hsa049170.64880117
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64483480
100Insulin secretion_Homo sapiens_hsa049110.64051115
101ErbB signaling pathway_Homo sapiens_hsa040120.63391866
102HTLV-I infection_Homo sapiens_hsa051660.61795789
103T cell receptor signaling pathway_Homo sapiens_hsa046600.61730159
104Legionellosis_Homo sapiens_hsa051340.61600560
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60562503
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.60083367
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60021985
108Focal adhesion_Homo sapiens_hsa045100.59542433
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57565560
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56973334
111Apoptosis_Homo sapiens_hsa042100.56363527
112Other glycan degradation_Homo sapiens_hsa005110.55976638
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.55051795
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.55021878
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54948465
116Amoebiasis_Homo sapiens_hsa051460.54822707
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54475910
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54407117
119Pertussis_Homo sapiens_hsa051330.54103865
120Cholinergic synapse_Homo sapiens_hsa047250.54019958
121Serotonergic synapse_Homo sapiens_hsa047260.53845699
122MAPK signaling pathway_Homo sapiens_hsa040100.53450838
123Ether lipid metabolism_Homo sapiens_hsa005650.53295570
124Pancreatic cancer_Homo sapiens_hsa052120.52937589
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52384646
126Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52375777
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52373501
128ECM-receptor interaction_Homo sapiens_hsa045120.51106554
129Ras signaling pathway_Homo sapiens_hsa040140.51024156
130Adherens junction_Homo sapiens_hsa045200.50792252
131Circadian rhythm_Homo sapiens_hsa047100.50088178
132Antigen processing and presentation_Homo sapiens_hsa046120.49874861
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49665996
134Renin secretion_Homo sapiens_hsa049240.49602952
135Pathways in cancer_Homo sapiens_hsa052000.49019535
136Chronic myeloid leukemia_Homo sapiens_hsa052200.48119588
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47373024
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.47058287
139Circadian entrainment_Homo sapiens_hsa047130.46963763
140Oxytocin signaling pathway_Homo sapiens_hsa049210.46718737
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45766218

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