PILRA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.48948475
2neutrophil activation involved in immune response (GO:0002283)6.41189979
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.67822094
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.67822094
5modulation by symbiont of host immune response (GO:0052553)5.67822094
6positive regulation by symbiont of host defense response (GO:0052509)5.67822094
7modulation by symbiont of host defense response (GO:0052031)5.67822094
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.67822094
9respiratory burst (GO:0045730)5.49414702
10hydrogen peroxide biosynthetic process (GO:0050665)5.37301186
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.23170923
12negative regulation of cell killing (GO:0031342)5.23170923
13immunoglobulin mediated immune response (GO:0016064)5.13846675
14positive regulation of gamma-delta T cell activation (GO:0046645)5.12789007
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.12544931
16production of molecular mediator involved in inflammatory response (GO:0002532)5.10775171
17superoxide anion generation (GO:0042554)4.97982149
18granulocyte activation (GO:0036230)4.87526509
19reactive oxygen species biosynthetic process (GO:1903409)4.78520610
20neutrophil activation (GO:0042119)4.70398722
21positive regulation of chemokine biosynthetic process (GO:0045080)4.65532279
22lipopolysaccharide-mediated signaling pathway (GO:0031663)4.59980230
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.58436759
24leukocyte aggregation (GO:0070486)4.46564591
25macrophage activation involved in immune response (GO:0002281)4.41859450
26positive regulation of cellular amide metabolic process (GO:0034250)4.27357056
27positive regulation of mast cell degranulation (GO:0043306)4.23630306
28positive regulation of mast cell activation involved in immune response (GO:0033008)4.23630306
29positive regulation of mast cell activation (GO:0033005)4.19764139
30cellular extravasation (GO:0045123)4.17572211
31response to host immune response (GO:0052572)4.12621069
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.12621069
33detection of bacterium (GO:0016045)4.07325504
34regulation of chemokine biosynthetic process (GO:0045073)4.01331564
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99309736
36positive regulation of interferon-alpha production (GO:0032727)3.96978877
37positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.96180466
38antigen processing and presentation of endogenous antigen (GO:0019883)3.93506290
39positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.87388191
40B cell mediated immunity (GO:0019724)3.80779653
41positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.78322545
42regulation of mast cell degranulation (GO:0043304)3.75426889
43regulation of interferon-alpha production (GO:0032647)3.74081840
44neutrophil mediated immunity (GO:0002446)3.70840424
45myeloid cell activation involved in immune response (GO:0002275)3.70166635
46regulation of gamma-delta T cell activation (GO:0046643)3.64847095
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.64625395
48positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.64396586
49detection of molecule of bacterial origin (GO:0032490)3.62239612
50regulation of mast cell activation (GO:0033003)3.61322347
51positive regulation of heat generation (GO:0031652)3.60898331
52regulation of fever generation (GO:0031620)3.60423712
53response to host (GO:0075136)3.59767851
54response to host defenses (GO:0052200)3.59767851
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.59767851
56regulation of interferon-beta biosynthetic process (GO:0045357)3.54890712
57negative regulation of interleukin-12 production (GO:0032695)3.52021125
58neutrophil chemotaxis (GO:0030593)3.50573242
59microglial cell activation (GO:0001774)3.48404297
60regulation of mast cell activation involved in immune response (GO:0033006)3.48163555
61type I interferon signaling pathway (GO:0060337)3.48009954
62cellular response to type I interferon (GO:0071357)3.48009954
63positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47551601
64positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.47327532
65detection of biotic stimulus (GO:0009595)3.47242521
66positive regulation of monocyte chemotaxis (GO:0090026)3.46543267
67positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.46341032
68response to muramyl dipeptide (GO:0032495)3.45618775
69response to type I interferon (GO:0034340)3.43849047
70germinal center formation (GO:0002467)3.42977354
71regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.41537508
72neutrophil migration (GO:1990266)3.40805844
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.40161374
74negative regulation of cytokine production involved in immune response (GO:0002719)3.37677391
75T-helper 1 type immune response (GO:0042088)3.37647594
76regulation of T cell tolerance induction (GO:0002664)3.36656888
77macrophage activation (GO:0042116)3.34749056
78regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.32278687
79negative regulation of lymphocyte mediated immunity (GO:0002707)3.31699932
80regulation of T-helper 1 cell differentiation (GO:0045625)3.29946178
81leukocyte mediated cytotoxicity (GO:0001909)3.29409943
82negative regulation of interleukin-17 production (GO:0032700)3.27934430
83negative regulation of myeloid cell apoptotic process (GO:0033033)3.25177135
84regulation of interleukin-8 biosynthetic process (GO:0045414)3.24511910
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23955573
86negative regulation of T cell mediated immunity (GO:0002710)3.22928534
87positive regulation of leukocyte degranulation (GO:0043302)3.21377013
88regulation of myeloid leukocyte mediated immunity (GO:0002886)3.20807582
89defense response to protozoan (GO:0042832)3.20600847
90regulation of mononuclear cell migration (GO:0071675)3.20458156
91response to protozoan (GO:0001562)3.20360202
92regulation of tolerance induction (GO:0002643)3.19197591
93phagosome maturation (GO:0090382)3.18646587
94cellular response to zinc ion (GO:0071294)3.18424344
95interferon-gamma-mediated signaling pathway (GO:0060333)3.12983123
96positive regulation of lymphocyte migration (GO:2000403)3.12806915
97regulation of leukocyte degranulation (GO:0043300)3.09846191
98positive regulation of type 2 immune response (GO:0002830)3.08614578
99positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.08068824
100negative regulation of leukocyte mediated immunity (GO:0002704)3.07688829
101regulation of antigen processing and presentation (GO:0002577)3.07686994
102detection of other organism (GO:0098543)3.06552744
103granulocyte chemotaxis (GO:0071621)3.05559699
104positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.03893475
105positive regulation of antigen processing and presentation (GO:0002579)3.03702381
106regulation of B cell receptor signaling pathway (GO:0050855)3.02503680
107eosinophil chemotaxis (GO:0048245)3.01627154
108positive regulation of toll-like receptor signaling pathway (GO:0034123)3.01115583
109detection of external biotic stimulus (GO:0098581)3.00888092
110regulation of lymphocyte chemotaxis (GO:1901623)3.00723785
111positive regulation of chemokine production (GO:0032722)2.99638818
112NIK/NF-kappaB signaling (GO:0038061)2.99402253
113negative regulation of erythrocyte differentiation (GO:0045647)2.99139627
114myeloid dendritic cell differentiation (GO:0043011)2.98506268
115eosinophil migration (GO:0072677)2.98029370
116positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.97499010
117granulocyte migration (GO:0097530)2.97495049
118regulation of T-helper 2 cell differentiation (GO:0045628)2.97205175
119lymphocyte chemotaxis (GO:0048247)2.96390327
120positive regulation of interferon-beta production (GO:0032728)2.96153727
121regulation of vitamin D biosynthetic process (GO:0060556)2.95194835
122regulation of heterotypic cell-cell adhesion (GO:0034114)2.94675107
123positive regulation of interleukin-6 production (GO:0032755)2.94600871
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94534371
125myeloid leukocyte activation (GO:0002274)2.94051409
126regulation of interleukin-12 production (GO:0032655)2.93699591
127myeloid leukocyte mediated immunity (GO:0002444)2.93648517
128positive regulation of NF-kappaB import into nucleus (GO:0042346)2.92948036
129leukocyte migration involved in inflammatory response (GO:0002523)2.84358830
130myeloid dendritic cell activation (GO:0001773)2.84310226
131regulation of podosome assembly (GO:0071801)2.83530136
132negative regulation of interleukin-6 production (GO:0032715)2.80408333
133regulation of type 2 immune response (GO:0002828)2.79504846
134positive regulation of interleukin-10 production (GO:0032733)2.76633598
135leukocyte degranulation (GO:0043299)2.75850107
136regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.74717413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.24325503
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.57215311
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.35674173
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.62715966
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.28514956
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.95815490
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.82271679
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.81201008
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.55082961
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.53198333
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.30069671
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.09703567
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07524494
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.84550408
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79500699
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70445131
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.58193715
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.44665233
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39155333
20* SPI1_23547873_ChIP-Seq_NB4_Human2.33348918
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.21799902
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.96933646
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.94333331
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89913078
25VDR_24787735_ChIP-Seq_THP-1_Human1.81752483
26CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.80856105
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77431130
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75140148
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74441079
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72683540
31PU_27001747_Chip-Seq_BMDM_Mouse1.71896813
32VDR_24763502_ChIP-Seq_THP-1_Human1.68180604
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.59399375
34TCF7_22412390_ChIP-Seq_EML_Mouse1.58520258
35SPI1_23127762_ChIP-Seq_K562_Human1.57144354
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57057517
37MYC_22102868_ChIP-Seq_BL_Human1.56316667
38MYB_26560356_Chip-Seq_TH2_Human1.55718942
39RUNX_20019798_ChIP-Seq_JUKART_Human1.53175397
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48748731
41CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48360101
42CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48178803
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44913777
44KDM2B_26808549_Chip-Seq_DND41_Human1.44795693
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41719861
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38917926
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38665320
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36991114
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.35241987
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.34317363
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34004517
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32296317
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31403503
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.30554985
55LXR_22292898_ChIP-Seq_THP-1_Human1.29899948
56SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29340681
57SCL_19346495_ChIP-Seq_HPC-7_Human1.29097577
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27624655
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25747135
60GATA1_22025678_ChIP-Seq_K562_Human1.23226650
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21677956
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20015162
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19142780
64GATA3_26560356_Chip-Seq_TH2_Human1.17074154
65MAF_26560356_Chip-Seq_TH1_Human1.16745838
66GATA1_19941826_ChIP-Seq_K562_Human1.13696062
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13401581
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10907781
69MYB_26560356_Chip-Seq_TH1_Human1.09879021
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09765231
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06904589
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04055971
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03536829
74GATA3_27048872_Chip-Seq_THYMUS_Human1.03205150
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02489906
76* BCL6_27268052_Chip-Seq_Bcells_Human1.02096448
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98710059
78NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98710059
79* BCOR_27268052_Chip-Seq_Bcells_Human0.96218806
80CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93763573
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91851897
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.88669086
83KDM2B_26808549_Chip-Seq_JURKAT_Human0.88456752
84EGR1_19032775_ChIP-ChIP_M12_Human0.87417797
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87338775
86TFEB_21752829_ChIP-Seq_HELA_Human0.84365358
87VDR_21846776_ChIP-Seq_THP-1_Human0.83038756
88E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81561239
89SPI1_20517297_ChIP-Seq_HL60_Human0.81344842
90* STAT1_20625510_ChIP-Seq_HELA_Human0.78647506
91NCOR1_26117541_ChIP-Seq_K562_Human0.77793455
92UTX_26944678_Chip-Seq_JUKART_Human0.77539008
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.76436400
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75787966
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75125461
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74785921
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.74449801
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73446979
99* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73318734
100SOX2_20726797_ChIP-Seq_SW620_Human0.72540946
101CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.69708625
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.66093530
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65679175
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.64709566
105RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.64110175
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63985165
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.63438690
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.62353319
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61809729
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61322491
111GATA2_19941826_ChIP-Seq_K562_Human0.59929567
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.59103331
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.58806920
114P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56765172
115CJUN_26792858_Chip-Seq_BT549_Human0.56656747
116SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.56379284
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55798538
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.54603651
119SMRT_27268052_Chip-Seq_Bcells_Human0.53857268
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.53411255
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.53411255
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.52939658
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.52541465
124* MAF_26560356_Chip-Seq_TH2_Human0.52200937

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.68031373
2MP0001835_abnormal_antigen_presentation4.46368435
3MP0009785_altered_susceptibility_to4.43213775
4MP0002148_abnormal_hypersensitivity_rea4.01616527
5MP0002419_abnormal_innate_immunity3.71438388
6MP0003303_peritoneal_inflammation3.66138675
7MP0003724_increased_susceptibility_to3.55620601
8MP0005000_abnormal_immune_tolerance3.44463142
9MP0005025_abnormal_response_to3.34079197
10MP0006082_CNS_inflammation3.23612389
11MP0002452_abnormal_antigen_presenting2.71232917
12MP0001790_abnormal_immune_system2.63685492
13MP0005387_immune_system_phenotype2.63685492
14MP0002723_abnormal_immune_serum2.56427027
15MP0001800_abnormal_humoral_immune2.50894565
16MP0005671_abnormal_response_to2.47242764
17MP0000685_abnormal_immune_system2.44250556
18MP0009764_decreased_sensitivity_to2.38953701
19MP0001533_abnormal_skeleton_physiology2.38288680
20MP0005058_abnormal_lysosome_morphology2.30143053
21MP0001819_abnormal_immune_cell2.28966626
22MP0001853_heart_inflammation2.28135742
23MP0002420_abnormal_adaptive_immunity2.25768323
24MP0005464_abnormal_platelet_physiology2.23282446
25MP0004510_myositis2.20653486
26MP0003075_altered_response_to2.13223477
27MP0009278_abnormal_bone_marrow2.10543826
28MP0002405_respiratory_system_inflammati2.05740778
29MP0001845_abnormal_inflammatory_respons2.04356668
30MP0003191_abnormal_cellular_cholesterol2.00243714
31MP0005167_abnormal_blood-brain_barrier1.99102177
32MP0000343_altered_response_to1.92801449
33MP0002006_tumorigenesis1.85148359
34MP0003448_altered_tumor_morphology1.84338935
35MP0008469_abnormal_protein_level1.83330426
36MP0004947_skin_inflammation1.81886110
37MP0000858_altered_metastatic_potential1.75263075
38MP0009333_abnormal_splenocyte_physiolog1.60508553
39MP0010155_abnormal_intestine_physiology1.57877382
40MP0005166_decreased_susceptibility_to1.56214123
41MP0000716_abnormal_immune_system1.50080189
42MP0003172_abnormal_lysosome_physiology1.46913014
43MP0003186_abnormal_redox_activity1.42192820
44MP0002998_abnormal_bone_remodeling1.41987764
45MP0003828_pulmonary_edema1.39260889
46MP0005310_abnormal_salivary_gland1.37363076
47MP0001545_abnormal_hematopoietic_system1.34229224
48MP0005397_hematopoietic_system_phenotyp1.34229224
49MP0002277_abnormal_respiratory_mucosa1.33166546
50MP0002398_abnormal_bone_marrow1.32611728
51MP0003806_abnormal_nucleotide_metabolis1.28842600
52MP0008260_abnormal_autophagy1.25957025
53MP0000604_amyloidosis1.25243963
54MP0004782_abnormal_surfactant_physiolog1.19739029
55MP0005164_abnormal_response_to1.19589361
56MP0002429_abnormal_blood_cell1.17252192
57MP0003690_abnormal_glial_cell1.13346424
58MP0005390_skeleton_phenotype1.12167031
59MP0001851_eye_inflammation1.11214765
60MP0009763_increased_sensitivity_to1.08690200
61MP0000689_abnormal_spleen_morphology1.08420390
62MP0003195_calcinosis1.06445805
63MP0002933_joint_inflammation0.98803731
64MP0002139_abnormal_hepatobiliary_system0.96781987
65MP0003183_abnormal_peptide_metabolism0.96253029
66MP0002722_abnormal_immune_system0.96245598
67MP0002254_reproductive_system_inflammat0.92913753
68MP0004883_abnormal_blood_vessel0.88878217
69MP0006054_spinal_hemorrhage0.88789818
70MP0009840_abnormal_foam_cell0.83112546
71MP0005076_abnormal_cell_differentiation0.83022471
72MP0005451_abnormal_body_composition0.82767922
73MP0005174_abnormal_tail_pigmentation0.80902617
74MP0000703_abnormal_thymus_morphology0.80434695
75MP0003453_abnormal_keratinocyte_physiol0.78338495
76MP0002166_altered_tumor_susceptibility0.76313861
77MP0002332_abnormal_exercise_endurance0.75366578
78MP0000920_abnormal_myelination0.74740533
79MP0003656_abnormal_erythrocyte_physiolo0.74631914
80MP0000249_abnormal_blood_vessel0.74258564
81MP0003329_amyloid_beta_deposits0.72037194
82MP0008874_decreased_physiological_sensi0.70573103
83MP0000569_abnormal_digit_pigmentation0.68509891
84MP0003795_abnormal_bone_structure0.66066979
85MP0003300_gastrointestinal_ulcer0.62869042
86MP0001873_stomach_inflammation0.62147112
87MP0002132_abnormal_respiratory_system0.60480114
88MP0002138_abnormal_hepatobiliary_system0.59979999
89MP0008873_increased_physiological_sensi0.59699251
90MP0004381_abnormal_hair_follicle0.58851298
91MP0000371_diluted_coat_color0.56713544
92MP0001542_abnormal_bone_strength0.56443122
93MP0003091_abnormal_cell_migration0.56425566
94MP0003566_abnormal_cell_adhesion0.55547480
95MP0000465_gastrointestinal_hemorrhage0.54400060
96MP0003045_fibrosis0.53294201
97MP0010307_abnormal_tumor_latency0.53168992
98MP0003136_yellow_coat_color0.51981569
99MP0003646_muscle_fatigue0.51872636
100MP0005535_abnormal_body_temperature0.51734183
101MP0000490_abnormal_crypts_of0.51572669
102MP0003866_abnormal_defecation0.50714802
103MP0002136_abnormal_kidney_physiology0.50595146
104MP0004808_abnormal_hematopoietic_stem0.50177228
105MP0001663_abnormal_digestive_system0.50016193
106MP0009765_abnormal_xenobiotic_induced0.49141634
107MP0003221_abnormal_cardiomyocyte_apopto0.49137815
108MP0000609_abnormal_liver_physiology0.48593193
109MP0005319_abnormal_enzyme/_coenzyme0.48284582
110MP0010386_abnormal_urinary_bladder0.48003678
111MP0005165_increased_susceptibility_to0.46585725
112MP0005381_digestive/alimentary_phenotyp0.45909184
113MP0002693_abnormal_pancreas_physiology0.41705988
114MP0000015_abnormal_ear_pigmentation0.41029039
115MP0008004_abnormal_stomach_pH0.39916626
116MP0003763_abnormal_thymus_physiology0.39695738

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)9.18970136
2Eczematoid dermatitis (HP:0000976)8.60104711
3Recurrent gram-negative bacterial infections (HP:0005420)8.27572651
4Recurrent bacterial skin infections (HP:0005406)8.25708822
5Mediastinal lymphadenopathy (HP:0100721)6.28002730
6Abnormality of macrophages (HP:0004311)5.81554532
7Gingivitis (HP:0000230)5.30872439
8Stomatitis (HP:0010280)5.09442879
9Obstructive lung disease (HP:0006536)4.97887435
10Chronic obstructive pulmonary disease (HP:0006510)4.97887435
11Recurrent skin infections (HP:0001581)4.97124291
12Systemic lupus erythematosus (HP:0002725)4.59633645
13Elevated erythrocyte sedimentation rate (HP:0003565)4.25485550
14Vacuolated lymphocytes (HP:0001922)4.12207659
15Recurrent fungal infections (HP:0002841)4.11898183
16Myositis (HP:0100614)4.11023070
17Orchitis (HP:0100796)3.97838900
18Optic neuritis (HP:0100653)3.90969591
19Retrobulbar optic neuritis (HP:0100654)3.90969591
20Autoimmune thrombocytopenia (HP:0001973)3.87019224
21Loss of speech (HP:0002371)3.55939160
22Urticaria (HP:0001025)3.54639006
23Glomerulonephritis (HP:0000099)3.43066406
24Vasculitis (HP:0002633)3.39680057
25Cellulitis (HP:0100658)3.37839125
26Pustule (HP:0200039)3.37223658
27Thick nail (HP:0001805)3.35500617
28Axonal loss (HP:0003447)3.33710846
29Periodontitis (HP:0000704)3.32924392
30Prostate neoplasm (HP:0100787)3.21003645
31Meningitis (HP:0001287)3.18890019
32Increased IgM level (HP:0003496)3.18781876
33Recurrent viral infections (HP:0004429)3.12642812
34Basal ganglia calcification (HP:0002135)3.10596562
35Increased neuronal autofluorescent lipopigment (HP:0002074)3.09095185
36Encephalitis (HP:0002383)3.07379524
37Chronic mucocutaneous candidiasis (HP:0002728)3.05427221
38Recurrent cutaneous fungal infections (HP:0011370)3.05427221
39Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.04973342
40Amyloidosis (HP:0011034)3.04711418
41Increased cerebral lipofuscin (HP:0011813)3.00668033
42Recurrent pneumonia (HP:0006532)3.00118567
43Interstitial pulmonary disease (HP:0006530)2.98201215
44Mutism (HP:0002300)2.86120484
45Disinhibition (HP:0000734)2.85535799
46Increased IgE level (HP:0003212)2.80901053
47T lymphocytopenia (HP:0005403)2.73504034
48Pulmonary infiltrates (HP:0002113)2.72389185
49Increased serum ferritin (HP:0003281)2.67546236
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.64326548
51Episodic fever (HP:0001954)2.63985567
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.61419153
53Abnormality of polysaccharide metabolism (HP:0011012)2.61419153
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.61419153
55Agnosia (HP:0010524)2.59580734
56Osteomyelitis (HP:0002754)2.56544116
57Joint hemorrhage (HP:0005261)2.56101724
58Recurrent lower respiratory tract infections (HP:0002783)2.51892704
59Chest pain (HP:0100749)2.51501026
60Leukocytosis (HP:0001974)2.50934225
61Parakeratosis (HP:0001036)2.48981044
62Hepatosplenomegaly (HP:0001433)2.48495324
63Gastrointestinal infarctions (HP:0005244)2.47256502
64Nephritis (HP:0000123)2.46000350
65Gingival bleeding (HP:0000225)2.45797665
66Pulmonary embolism (HP:0002204)2.43852811
67Abnormality of glycolipid metabolism (HP:0010969)2.43024622
68Abnormality of liposaccharide metabolism (HP:0010968)2.43024622
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.43024622
70Hemoptysis (HP:0002105)2.37575315
71Petechiae (HP:0000967)2.32882489
72Poor head control (HP:0002421)2.32637170
73Abnormality of iron homeostasis (HP:0011031)2.32532549
74Keratoconjunctivitis sicca (HP:0001097)2.30618026
75Dysostosis multiplex (HP:0000943)2.30600029
76Hypochromic microcytic anemia (HP:0004840)2.29490543
77Polyneuropathy (HP:0001271)2.25086195
78Arterial thrombosis (HP:0004420)2.25052479
79Premature loss of primary teeth (HP:0006323)2.23161227
80Sepsis (HP:0100806)2.21330448
81Purpura (HP:0000979)2.19676529
82Hypergammaglobulinemia (HP:0010702)2.17252813
83Inflammation of the large intestine (HP:0002037)2.13716406
84Progressive neurologic deterioration (HP:0002344)2.10782985
85Hypochromic anemia (HP:0001931)2.10462021
86Keratoconjunctivitis (HP:0001096)2.09612926
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.09458400
88Osteolytic defects of the hand bones (HP:0009699)2.09458400
89Vertigo (HP:0002321)2.07603767
90Neurofibrillary tangles (HP:0002185)2.06578390
91Tetraparesis (HP:0002273)2.04586155
92Neuronal loss in central nervous system (HP:0002529)2.03881198
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03214613
94Spontaneous hematomas (HP:0007420)2.01720847
95Abnormality of the endocardium (HP:0004306)2.01537061
96Myocardial infarction (HP:0001658)2.01475158
97Glomerulopathy (HP:0100820)2.01375320
98Abnormality of the prostate (HP:0008775)2.01230231
99Hematochezia (HP:0002573)2.01141036
100Gastrointestinal inflammation (HP:0004386)2.00923592
101Skin ulcer (HP:0200042)2.00822975
102Acne (HP:0001061)2.00692432
103Cheilitis (HP:0100825)2.00622637
104Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00302018
105Abnormality of the pleura (HP:0002103)1.98893673
106Inappropriate behavior (HP:0000719)1.98693174
107Abnormality of complement system (HP:0005339)1.94532338
108Abnormality of T cells (HP:0002843)1.93364520
109Nausea (HP:0002018)1.93012179
110Epistaxis (HP:0000421)1.92641823
111Chronic otitis media (HP:0000389)1.92345406
112Memory impairment (HP:0002354)1.91227262
113Bone pain (HP:0002653)1.88741012
114Anorexia (HP:0002039)1.88519010
115Abnormality of the pericardium (HP:0001697)1.87582741
116Arthralgia (HP:0002829)1.86040539
117Neoplasm of head and neck (HP:0012288)1.84414734
118Esophageal neoplasm (HP:0100751)1.84414734
119Menorrhagia (HP:0000132)1.83222159
120Abnormality of T cell number (HP:0011839)1.82613235
121Peritonitis (HP:0002586)1.81910904
122Joint swelling (HP:0001386)1.79625103
123Pathologic fracture (HP:0002756)1.79221644
124Gangrene (HP:0100758)1.77292326
125Eosinophilia (HP:0001880)1.74934485
126Gastrointestinal stroma tumor (HP:0100723)1.72708650
127Upper motor neuron abnormality (HP:0002127)1.71761699
128Prolonged bleeding time (HP:0003010)1.71210932
129Mucopolysacchariduria (HP:0008155)1.71122156
130Urinary glycosaminoglycan excretion (HP:0003541)1.71122156
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.68970941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.47132267
2BLK4.63567235
3MAP3K144.05507960
4IRAK43.94622267
5PBK3.39990380
6IRAK33.18275959
7TBK13.00672387
8MAP4K12.66133019
9TXK2.47753893
10TYK22.35253631
11IKBKB2.32132377
12TAOK12.17515644
13IKBKE2.06400464
14MAP3K31.99749774
15CSK1.98811753
16FGR1.87330448
17JAK31.83202889
18TNK21.81372207
19TAOK21.74690715
20PIM21.67206298
21BMPR21.58466990
22MST41.47490832
23KIT1.39302302
24HCK1.38419426
25YES11.37673015
26JAK11.33658311
27ERN11.31684378
28LYN1.31509174
29CLK11.29266513
30SYK1.29139035
31ABL21.27018485
32ZAP701.26880632
33TEC1.25781532
34BTK1.24265961
35MAP3K121.20710914
36NME21.17417353
37MAP3K131.15306637
38STK101.13689509
39MARK31.13164988
40RPS6KA41.12980581
41CSF1R1.10013908
42GRK71.09919865
43CHUK1.09049594
44FES1.06352660
45CDC42BPA1.06256460
46NEK91.06043228
47PIM11.05734944
48BMX1.05290168
49EIF2AK21.03908397
50KSR21.01483657
51MST1R0.99632045
52LCK0.99321084
53EPHB10.98405816
54JAK20.97908476
55TRPM70.93478266
56MATK0.89998586
57PRKCD0.89212911
58ERBB30.89112928
59DDR20.86461362
60IRAK20.86047683
61SIK20.75249470
62MAP3K110.75044152
63STK40.74955965
64MARK20.73389183
65ACVR1B0.71478363
66CAMKK20.71463050
67ABL10.68180833
68IRAK10.66562432
69MAP3K50.64868277
70EIF2AK10.62805068
71TAOK30.62008097
72ADRBK20.61625896
73TGFBR20.61225887
74MAP2K30.59952992
75TESK10.59319830
76PRKD20.58869816
77EGFR0.55704120
78MAP2K60.52582966
79PRKCQ0.50117313
80MAPK70.47472336
81PTK60.46612656
82RPS6KC10.46532359
83RPS6KL10.46532359
84FYN0.44331473
85CDK190.43214171
86MAPK120.43187728
87HIPK20.43160780
88ITK0.43011546
89EPHA30.42466340
90MAP3K60.42113052
91KSR10.40741488
92LRRK20.40244798
93DYRK1B0.38833846
94EIF2AK30.38071867
95DYRK30.37467274
96PDPK10.36786851
97FGFR30.36396403
98PIK3CG0.36185477
99CAMK1D0.35905997
100RIPK10.34415586
101STK30.34372430
102DAPK30.34202510
103BMPR1B0.34180141
104SIK10.33778452
105ARAF0.33741601
106PDK10.33686347
107SGK30.33320193
108MOS0.33133859
109ADRBK10.32774866
110MAPKAPK20.32709303
111SIK30.32623926
112ERBB40.32196850
113STK110.30789907
114TRIB30.30583201
115MAP2K40.30027101
116GRK60.28895043
117DMPK0.25751535
118RPS6KA60.25733742
119CAMKK10.25552336
120TLK10.25116121
121RPS6KA20.23680227
122IGF1R0.22693308
123PRKG20.21049330
124DAPK20.20456066
125MAP3K10.19558914
126TTN0.19087339
127INSR0.17255008
128PRKCH0.16805322
129GRK50.16715517
130PRPF4B0.15871987
131MUSK0.13720765
132MAPK40.13550885
133TESK20.13502422

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.98250369
2Graft-versus-host disease_Homo sapiens_hsa053323.97146963
3Leishmaniasis_Homo sapiens_hsa051403.83231764
4Legionellosis_Homo sapiens_hsa051343.14414066
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.78289928
6Pertussis_Homo sapiens_hsa051332.69075329
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.63636222
8Rheumatoid arthritis_Homo sapiens_hsa053232.56859610
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.53503782
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.51367137
11Malaria_Homo sapiens_hsa051442.46263287
12Allograft rejection_Homo sapiens_hsa053302.46161306
13Tuberculosis_Homo sapiens_hsa051522.44652824
14Type I diabetes mellitus_Homo sapiens_hsa049402.42926993
15Asthma_Homo sapiens_hsa053102.36741940
16Osteoclast differentiation_Homo sapiens_hsa043802.33157627
17Salmonella infection_Homo sapiens_hsa051322.25283131
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.24759415
19Phagosome_Homo sapiens_hsa041451.97250041
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.96318614
21African trypanosomiasis_Homo sapiens_hsa051431.84674358
22Measles_Homo sapiens_hsa051621.81247002
23TNF signaling pathway_Homo sapiens_hsa046681.78115099
24Hematopoietic cell lineage_Homo sapiens_hsa046401.76936427
25Influenza A_Homo sapiens_hsa051641.59236462
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.54559624
27Lysosome_Homo sapiens_hsa041421.54270089
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49906863
29Chemokine signaling pathway_Homo sapiens_hsa040621.48659394
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46970712
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36344887
32B cell receptor signaling pathway_Homo sapiens_hsa046621.36037518
33Toxoplasmosis_Homo sapiens_hsa051451.31051483
34Shigellosis_Homo sapiens_hsa051311.24563247
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23956321
36* Herpes simplex infection_Homo sapiens_hsa051681.20092920
37Other glycan degradation_Homo sapiens_hsa005111.17034511
38Apoptosis_Homo sapiens_hsa042101.12299252
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.06689166
40Amoebiasis_Homo sapiens_hsa051461.04220777
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02936989
42Autoimmune thyroid disease_Homo sapiens_hsa053201.00108055
43Complement and coagulation cascades_Homo sapiens_hsa046100.99313963
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.98886200
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98390798
46Prion diseases_Homo sapiens_hsa050200.97602798
47Viral myocarditis_Homo sapiens_hsa054160.91477138
48Hepatitis B_Homo sapiens_hsa051610.90664549
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87434288
50Antigen processing and presentation_Homo sapiens_hsa046120.84207999
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82616772
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.80739738
53Hepatitis C_Homo sapiens_hsa051600.78197270
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76038351
55Collecting duct acid secretion_Homo sapiens_hsa049660.70702063
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68402687
57Primary immunodeficiency_Homo sapiens_hsa053400.63002579
58T cell receptor signaling pathway_Homo sapiens_hsa046600.61157974
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59207004
60Steroid biosynthesis_Homo sapiens_hsa001000.57469074
61Bladder cancer_Homo sapiens_hsa052190.55706660
62Platelet activation_Homo sapiens_hsa046110.52709883
63Non-small cell lung cancer_Homo sapiens_hsa052230.51559444
64Acute myeloid leukemia_Homo sapiens_hsa052210.48212394
65Mineral absorption_Homo sapiens_hsa049780.47386136
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46845081
67Renal cell carcinoma_Homo sapiens_hsa052110.46836758
68Epstein-Barr virus infection_Homo sapiens_hsa051690.45220706
69Notch signaling pathway_Homo sapiens_hsa043300.44994872
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.43336738
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42817354
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42635664
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.42621754
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41301663
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40337815
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.39326196
77HTLV-I infection_Homo sapiens_hsa051660.38188981
78Proteasome_Homo sapiens_hsa030500.37842242
79GnRH signaling pathway_Homo sapiens_hsa049120.36035310
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.35764894
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32698157
82Dorso-ventral axis formation_Homo sapiens_hsa043200.31318788
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31181492
84Pancreatic cancer_Homo sapiens_hsa052120.30136375
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29879589
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27905763
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26844612
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26260639
89HIF-1 signaling pathway_Homo sapiens_hsa040660.26017555
90Prolactin signaling pathway_Homo sapiens_hsa049170.25542087
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24958455
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24648242
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23781827
94Sphingolipid metabolism_Homo sapiens_hsa006000.21508318
95Chronic myeloid leukemia_Homo sapiens_hsa052200.21103525
96Caffeine metabolism_Homo sapiens_hsa002320.20760482
97mTOR signaling pathway_Homo sapiens_hsa041500.20356172
98Rap1 signaling pathway_Homo sapiens_hsa040150.19748864
99Type II diabetes mellitus_Homo sapiens_hsa049300.19623876
100Vibrio cholerae infection_Homo sapiens_hsa051100.17929924
101Histidine metabolism_Homo sapiens_hsa003400.16385121
102Arachidonic acid metabolism_Homo sapiens_hsa005900.15741668
103Ether lipid metabolism_Homo sapiens_hsa005650.14832477
104Viral carcinogenesis_Homo sapiens_hsa052030.14659662
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14501636
106Endocytosis_Homo sapiens_hsa041440.12616699
107VEGF signaling pathway_Homo sapiens_hsa043700.11657315
108Insulin resistance_Homo sapiens_hsa049310.11393465
109Proteoglycans in cancer_Homo sapiens_hsa052050.09009462
110Systemic lupus erythematosus_Homo sapiens_hsa053220.07265086
111Pentose phosphate pathway_Homo sapiens_hsa000300.05991799
112FoxO signaling pathway_Homo sapiens_hsa040680.04761756
113MAPK signaling pathway_Homo sapiens_hsa040100.03430830
114Regulation of autophagy_Homo sapiens_hsa041400.02644055

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