PIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.59752941
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.55904636
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48251301
4protoporphyrinogen IX metabolic process (GO:0046501)4.47365005
5oxygen transport (GO:0015671)4.42580693
6neutrophil activation involved in immune response (GO:0002283)4.25279659
7positive regulation of gamma-delta T cell activation (GO:0046645)4.21962082
8gas transport (GO:0015669)4.02861457
9antigen processing and presentation of endogenous antigen (GO:0019883)3.98466535
10response to muramyl dipeptide (GO:0032495)3.92944522
11NIK/NF-kappaB signaling (GO:0038061)3.89126584
12regulation of interleukin-12 biosynthetic process (GO:0045075)3.85197884
13erythrocyte development (GO:0048821)3.85054889
14erythrocyte maturation (GO:0043249)3.83767560
15positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83237374
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.81414590
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.81414590
18response to peptidoglycan (GO:0032494)3.77438138
19myeloid dendritic cell differentiation (GO:0043011)3.70660446
20immunoglobulin mediated immune response (GO:0016064)3.70543303
21myeloid dendritic cell activation (GO:0001773)3.66271081
22granulocyte activation (GO:0036230)3.59229874
23positive regulation of granulocyte differentiation (GO:0030854)3.57507921
24positive regulation of interferon-alpha production (GO:0032727)3.57376001
25neutrophil activation (GO:0042119)3.53993963
26protoporphyrinogen IX biosynthetic process (GO:0006782)3.46668495
27mucosal-associated lymphoid tissue development (GO:0048537)3.44404366
28Peyers patch development (GO:0048541)3.44404366
29regulation of interferon-alpha production (GO:0032647)3.43289846
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.41883291
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.41883291
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.41883291
33modulation by symbiont of host immune response (GO:0052553)3.41883291
34positive regulation by symbiont of host defense response (GO:0052509)3.41883291
35modulation by symbiont of host defense response (GO:0052031)3.41883291
36T cell migration (GO:0072678)3.34716370
37regulation of T-helper 1 cell differentiation (GO:0045625)3.33926190
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33771626
39leukocyte aggregation (GO:0070486)3.33707678
40response to type I interferon (GO:0034340)3.33552694
41type I interferon signaling pathway (GO:0060337)3.32234373
42cellular response to type I interferon (GO:0071357)3.32234373
43positive thymic T cell selection (GO:0045059)3.29628747
44response to interleukin-15 (GO:0070672)3.28595761
45interferon-gamma production (GO:0032609)3.26416712
46germinal center formation (GO:0002467)3.25390403
47negative regulation of T cell mediated immunity (GO:0002710)3.24426902
48detection of other organism (GO:0098543)3.21589713
49interferon-gamma-mediated signaling pathway (GO:0060333)3.21286534
50definitive hemopoiesis (GO:0060216)3.17252322
51positive regulation of interleukin-2 production (GO:0032743)3.16470365
52regulation of gamma-delta T cell activation (GO:0046643)3.16047359
53respiratory burst (GO:0045730)3.13810492
54positive regulation of interleukin-12 production (GO:0032735)3.11697571
55regulation of alpha-beta T cell proliferation (GO:0046640)3.11543948
56positive regulation of antigen processing and presentation (GO:0002579)3.11252150
57regulation of erythrocyte differentiation (GO:0045646)3.10635449
58defense response to protozoan (GO:0042832)3.10400207
59regulation of gamma-delta T cell differentiation (GO:0045586)3.09938491
60detection of bacterium (GO:0016045)3.09682770
61B cell mediated immunity (GO:0019724)3.08988492
62macrophage activation involved in immune response (GO:0002281)3.05813501
63positive regulation of alpha-beta T cell proliferation (GO:0046641)3.05599040
64myeloid cell development (GO:0061515)3.04888925
65positive regulation of B cell differentiation (GO:0045579)3.04430153
66natural killer cell mediated cytotoxicity (GO:0042267)3.03340128
67natural killer cell mediated immunity (GO:0002228)3.03340128
68regulation of mast cell degranulation (GO:0043304)3.02114446
69JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.01321706
70response to protozoan (GO:0001562)2.99856060
71positive regulation of isotype switching (GO:0045830)2.98787846
72regulation of RIG-I signaling pathway (GO:0039535)2.97835574
73B cell receptor signaling pathway (GO:0050853)2.97307587
74positive regulation of interferon-beta production (GO:0032728)2.97292387
75cellular response to zinc ion (GO:0071294)2.97093503
76positive T cell selection (GO:0043368)2.96241251
77positive regulation of immunoglobulin mediated immune response (GO:0002891)2.95512452
78positive regulation of B cell mediated immunity (GO:0002714)2.95512452
79positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95191698
80cellular response to interferon-beta (GO:0035458)2.94975990
81granulocyte differentiation (GO:0030851)2.92507593
82thymic T cell selection (GO:0045061)2.91040693
83positive regulation of natural killer cell differentiation (GO:0032825)2.89433118
84T cell selection (GO:0045058)2.88575608
85dendritic cell differentiation (GO:0097028)2.88110961
86regulation of hypersensitivity (GO:0002883)2.87811819
87negative regulation of lymphocyte mediated immunity (GO:0002707)2.87256589
88negative regulation of interleukin-12 production (GO:0032695)2.86898523
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86847293
90positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.86573897
91response to interferon-beta (GO:0035456)2.85507833
92megakaryocyte development (GO:0035855)2.85314865
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.84963925
94positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.84699215
95negative thymic T cell selection (GO:0045060)2.84600986
96regulation of B cell differentiation (GO:0045577)2.84525294
97natural killer cell differentiation (GO:0001779)2.84087595
98regulation of interleukin-12 production (GO:0032655)2.83865693
99negative regulation of viral genome replication (GO:0045071)2.82962083
1003-UTR-mediated mRNA stabilization (GO:0070935)2.82429372
101regulation of interleukin-2 biosynthetic process (GO:0045076)2.79586548
102Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79466333
103natural killer cell activation (GO:0030101)2.78413441
104leukocyte degranulation (GO:0043299)2.77943421
105monocyte chemotaxis (GO:0002548)2.77743984
106positive regulation of chemokine biosynthetic process (GO:0045080)2.76573950
107positive regulation of cytokine biosynthetic process (GO:0042108)2.76409933
108positive regulation of humoral immune response (GO:0002922)2.76334188
109regulation of antigen processing and presentation (GO:0002577)2.76198454
110regulation of chronic inflammatory response (GO:0002676)2.76131190
111regulation of granulocyte differentiation (GO:0030852)2.75746794
112positive regulation of interleukin-17 production (GO:0032740)2.75504661
113regulation of histone H3-K27 methylation (GO:0061085)2.74265453
114cellular extravasation (GO:0045123)2.74133561
115regulation of B cell receptor signaling pathway (GO:0050855)2.74001959
116negative T cell selection (GO:0043383)2.72689023
117regulation of activation of Janus kinase activity (GO:0010533)2.72240728
118cellular response to thyroid hormone stimulus (GO:0097067)2.71924638
119detection of external biotic stimulus (GO:0098581)2.71907053
120tolerance induction (GO:0002507)2.71644107
121porphyrin-containing compound biosynthetic process (GO:0006779)2.71311149
122regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.71259764
123regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71231534
124myeloid cell activation involved in immune response (GO:0002275)2.70876920
125negative regulation of cytokine production involved in immune response (GO:0002719)2.69838037
126positive regulation of T-helper 1 type immune response (GO:0002827)2.69642593
127regulation of fever generation (GO:0031620)2.69637424
128cytokine secretion (GO:0050663)2.69420430
129positive regulation of T-helper cell differentiation (GO:0045624)2.69361165
130T-helper 1 type immune response (GO:0042088)2.69255540
131positive regulation of heat generation (GO:0031652)2.69159297
132negative regulation of cell killing (GO:0031342)2.68944647
133negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68944647
134regulation of mast cell activation involved in immune response (GO:0033006)2.68937564
135positive regulation of DNA recombination (GO:0045911)2.67595287
136regulation of T-helper cell differentiation (GO:0045622)2.67226514
137negative regulation of leukocyte mediated immunity (GO:0002704)2.66719491
138regulation of necroptotic process (GO:0060544)2.66428939
139regulation of T-helper 1 type immune response (GO:0002825)2.66403855
140production of molecular mediator involved in inflammatory response (GO:0002532)2.66146571
141regulation of interferon-beta biosynthetic process (GO:0045357)2.65592948
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.65147179
143hemoglobin metabolic process (GO:0020027)2.65129023
144positive regulation of interferon-gamma production (GO:0032729)2.64812361
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63658870
146modulation by symbiont of host cellular process (GO:0044068)2.63645946
147modulation by virus of host process (GO:0019054)2.62272176
148regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57044022
149detection of molecule of bacterial origin (GO:0032490)2.56966579
150regulation of myeloid leukocyte mediated immunity (GO:0002886)2.54886565
151positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.50377401
152regulation of leukocyte degranulation (GO:0043300)2.50184622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.74749375
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.51749940
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.81996977
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.46122589
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.97071487
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.81121007
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.48136287
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.37424200
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22433120
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.21295032
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15287958
12* GATA1_19941826_ChIP-Seq_K562_Human3.08532893
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.07188425
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.93556742
15* E2F7_22180533_ChIP-Seq_HELA_Human2.90220329
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90139543
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.90013783
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81414890
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.70918233
20SCL_19346495_ChIP-Seq_HPC-7_Human2.49243675
21* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34774752
22* MYB_26560356_Chip-Seq_TH2_Human2.27951412
23SPI1_23547873_ChIP-Seq_NB4_Human2.15697944
24MYC_22102868_ChIP-Seq_BL_Human2.12526350
25* MAF_26560356_Chip-Seq_TH1_Human2.09700597
26* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09231905
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.08008309
28VDR_21846776_ChIP-Seq_THP-1_Human2.04590190
29* GATA2_19941826_ChIP-Seq_K562_Human2.04330513
30RUNX_20019798_ChIP-Seq_JUKART_Human2.01286570
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99150974
32* MYB_26560356_Chip-Seq_TH1_Human1.98223340
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.95157434
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93004013
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.90955863
36VDR_24763502_ChIP-Seq_THP-1_Human1.87996638
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.86714980
38* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84999725
39* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81532174
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.65291611
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.62153867
42UTX_26944678_Chip-Seq_JUKART_Human1.58026609
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.54188831
44PU_27001747_Chip-Seq_BMDM_Mouse1.52673836
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48944353
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47350835
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42692692
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39476664
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37946918
50* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37542358
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36462817
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36392467
53MAF_26560356_Chip-Seq_TH2_Human1.35668200
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34602846
55* FOXM1_23109430_ChIP-Seq_U2OS_Human1.30144311
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27104152
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26381840
58SPI1_23127762_ChIP-Seq_K562_Human1.25678262
59* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24418812
60CIITA_25753668_ChIP-Seq_RAJI_Human1.23001476
61* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22899195
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.22827757
63* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16648745
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16020189
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.15842553
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15393219
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15023236
68VDR_24787735_ChIP-Seq_THP-1_Human1.14773435
69* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14700214
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14423495
71LXR_22292898_ChIP-Seq_THP-1_Human1.13510581
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10689506
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09693673
74GATA1_22025678_ChIP-Seq_K562_Human1.08600147
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08400035
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07758715
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07360819
78* ELK3_25401928_ChIP-Seq_HUVEC_Human1.07056502
79* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06439455
80GATA3_26560356_Chip-Seq_TH2_Human1.06039764
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02347123
82* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01764109
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.01520746
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01502762
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00191916
86* KDM2B_26808549_Chip-Seq_DND41_Human0.99978764
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99043246
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98911614
89* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98884188
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96710031
91* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95847077
92* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93354980
93* NCOR1_26117541_ChIP-Seq_K562_Human0.92771797
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92642643
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.92293098
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92142910
97ELK1_19687146_ChIP-ChIP_HELA_Human0.91528342
98* BCOR_27268052_Chip-Seq_Bcells_Human0.90364419
99* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90198276
100TFEB_21752829_ChIP-Seq_HELA_Human0.89217819
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87112227
102ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86919898
103* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85040561
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84857489
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82691019
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.82353879
107* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80606059
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.80429132
109* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78892610
110TP63_19390658_ChIP-ChIP_HaCaT_Human0.77425700
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.76719564
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75532211
113VDR_23849224_ChIP-Seq_CD4+_Human0.75460822
114KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.74159356
115KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.74159356
116KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.74159356
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73065100
118* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70985604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.30410172
2MP0003436_decreased_susceptibility_to3.57657091
3MP0009785_altered_susceptibility_to3.37586711
4MP0002148_abnormal_hypersensitivity_rea3.32952342
5MP0005671_abnormal_response_to3.24230768
6MP0000685_abnormal_immune_system3.16891629
7MP0005000_abnormal_immune_tolerance3.11080039
8MP0005387_immune_system_phenotype2.93383208
9MP0001790_abnormal_immune_system2.93383208
10MP0003303_peritoneal_inflammation2.88077972
11MP0001800_abnormal_humoral_immune2.83603191
12MP0005025_abnormal_response_to2.79313962
13MP0005451_abnormal_body_composition2.75438029
14* MP0002452_abnormal_antigen_presenting2.68108818
15MP0002419_abnormal_innate_immunity2.63459143
16MP0002723_abnormal_immune_serum2.62593232
17MP0004510_myositis2.60098391
18MP0004147_increased_porphyrin_level2.59899324
19MP0006082_CNS_inflammation2.59557836
20MP0003724_increased_susceptibility_to2.51644169
21* MP0001819_abnormal_immune_cell2.42526780
22* MP0002420_abnormal_adaptive_immunity2.40985792
23MP0002405_respiratory_system_inflammati2.26513628
24* MP0002398_abnormal_bone_marrow2.07699598
25MP0003763_abnormal_thymus_physiology2.06654428
26MP0001853_heart_inflammation2.05700709
27MP0010155_abnormal_intestine_physiology2.02803734
28MP0002006_tumorigenesis1.98532791
29MP0005464_abnormal_platelet_physiology1.97419040
30* MP0000716_abnormal_immune_system1.92409349
31MP0009333_abnormal_splenocyte_physiolog1.92190502
32MP0004947_skin_inflammation1.91851654
33MP0009278_abnormal_bone_marrow1.87009524
34MP0005397_hematopoietic_system_phenotyp1.86522894
35MP0001545_abnormal_hematopoietic_system1.86522894
36MP0003172_abnormal_lysosome_physiology1.79843723
37MP0002166_altered_tumor_susceptibility1.79601424
38MP0001845_abnormal_inflammatory_respons1.78923726
39MP0003448_altered_tumor_morphology1.78508157
40MP0008260_abnormal_autophagy1.76541887
41MP0000689_abnormal_spleen_morphology1.71375200
42MP0005083_abnormal_biliary_tract1.68188346
43MP0002722_abnormal_immune_system1.67103317
44* MP0002429_abnormal_blood_cell1.62196306
45MP0002138_abnormal_hepatobiliary_system1.62140999
46MP0001533_abnormal_skeleton_physiology1.61255688
47MP0005310_abnormal_salivary_gland1.55180680
48MP0005076_abnormal_cell_differentiation1.53297707
49MP0000858_altered_metastatic_potential1.52779271
50MP0004808_abnormal_hematopoietic_stem1.48237030
51MP0009764_decreased_sensitivity_to1.47859323
52MP0003300_gastrointestinal_ulcer1.45789615
53MP0008057_abnormal_DNA_replication1.44833532
54MP0000490_abnormal_crypts_of1.38269198
55MP0008469_abnormal_protein_level1.35952398
56MP0002396_abnormal_hematopoietic_system1.35714969
57MP0010307_abnormal_tumor_latency1.32919633
58MP0010352_gastrointestinal_tract_polyps1.32578995
59MP0000703_abnormal_thymus_morphology1.31776493
60MP0001873_stomach_inflammation1.29373490
61MP0003866_abnormal_defecation1.26409710
62MP0008995_early_reproductive_senescence1.21795721
63MP0000343_altered_response_to1.18666628
64MP0002877_abnormal_melanocyte_morpholog1.15146317
65MP0002277_abnormal_respiratory_mucosa1.13000733
66MP0003453_abnormal_keratinocyte_physiol1.12992938
67MP0002998_abnormal_bone_remodeling1.11945387
68MP0002254_reproductive_system_inflammat1.08848998
69MP0005174_abnormal_tail_pigmentation1.06006303
70MP0002009_preneoplasia1.04127579
71MP0000465_gastrointestinal_hemorrhage1.03954661
72MP0003806_abnormal_nucleotide_metabolis1.03238138
73MP0003828_pulmonary_edema1.00305909
74MP0003221_abnormal_cardiomyocyte_apopto0.98451544
75MP0002933_joint_inflammation0.96159365
76MP0004782_abnormal_surfactant_physiolog0.93253247
77MP0002019_abnormal_tumor_incidence0.92416488
78MP0001851_eye_inflammation0.92141302
79MP0003111_abnormal_nucleus_morphology0.88519147
80MP0000609_abnormal_liver_physiology0.87272502
81MP0008004_abnormal_stomach_pH0.86661565
82MP0005390_skeleton_phenotype0.86261251
83MP0003191_abnormal_cellular_cholesterol0.86082615
84MP0004185_abnormal_adipocyte_glucose0.85075393
85MP0003566_abnormal_cell_adhesion0.83186319
86MP0009763_increased_sensitivity_to0.82623281
87MP0008007_abnormal_cellular_replicative0.82238855
88MP0003656_abnormal_erythrocyte_physiolo0.80815633
89MP0003075_altered_response_to0.80224127
90MP0001348_abnormal_lacrimal_gland0.79987788
91MP0004883_abnormal_blood_vessel0.79721712
92MP0005058_abnormal_lysosome_morphology0.77901245
93MP0000604_amyloidosis0.77573599
94MP0009931_abnormal_skin_appearance0.76858963
95MP0002132_abnormal_respiratory_system0.76667216
96MP0003077_abnormal_cell_cycle0.75408953
97MP0005166_decreased_susceptibility_to0.71501705
98MP0003690_abnormal_glial_cell0.70490478
99MP0010094_abnormal_chromosome_stability0.67712474
100MP0005666_abnormal_adipose_tissue0.67677260
101MP0002332_abnormal_exercise_endurance0.67085448
102MP0000371_diluted_coat_color0.65918954
103MP0003186_abnormal_redox_activity0.65571549
104MP0000249_abnormal_blood_vessel0.64347059
105MP0001663_abnormal_digestive_system0.64305712
106MP0002139_abnormal_hepatobiliary_system0.63728346
107MP0004381_abnormal_hair_follicle0.63710547
108MP0009840_abnormal_foam_cell0.61291300
109MP0001881_abnormal_mammary_gland0.61056709
110MP0008058_abnormal_DNA_repair0.60221568
111MP0000313_abnormal_cell_death0.60206373
112MP0009115_abnormal_fat_cell0.59627212
113MP0005636_abnormal_mineral_homeostasis0.59160454
114MP0005023_abnormal_wound_healing0.58969737
115MP0002163_abnormal_gland_morphology0.58526513
116MP0005621_abnormal_cell_physiology0.57944676
117MP0000627_abnormal_mammary_gland0.57753363
118MP0000015_abnormal_ear_pigmentation0.57409176
119MP0003693_abnormal_embryo_hatching0.57251273
120MP0003795_abnormal_bone_structure0.56960654
121MP0001216_abnormal_epidermal_layer0.56832573
122MP0009765_abnormal_xenobiotic_induced0.56114708
123MP0005164_abnormal_response_to0.56077211
124MP0003091_abnormal_cell_migration0.55175612
125MP0002136_abnormal_kidney_physiology0.53261760

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.19455944
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.78195482
3Recurrent abscess formation (HP:0002722)5.69946012
4Recurrent bacterial skin infections (HP:0005406)5.28165202
5Myositis (HP:0100614)4.86303716
6Retrobulbar optic neuritis (HP:0100654)4.82398747
7Optic neuritis (HP:0100653)4.82398747
8Orchitis (HP:0100796)4.64026351
9Mediastinal lymphadenopathy (HP:0100721)4.47138775
10Elevated erythrocyte sedimentation rate (HP:0003565)4.44184958
11Poikilocytosis (HP:0004447)4.38224960
12Recurrent fungal infections (HP:0002841)4.22376559
13Recurrent gram-negative bacterial infections (HP:0005420)4.19654351
14Reticulocytosis (HP:0001923)4.19195609
15Autoimmune thrombocytopenia (HP:0001973)4.07419676
16Cholecystitis (HP:0001082)3.95946751
17Abnormal gallbladder physiology (HP:0012438)3.95946751
18Polycythemia (HP:0001901)3.95788285
19Stomatitis (HP:0010280)3.82533123
20Abnormality of macrophages (HP:0004311)3.82413976
21Vasculitis (HP:0002633)3.68276397
22Recurrent viral infections (HP:0004429)3.66907147
23Increased IgM level (HP:0003496)3.56600568
24Cellulitis (HP:0100658)3.50974937
25Pustule (HP:0200039)3.45075903
26Obstructive lung disease (HP:0006536)3.43968505
27Chronic obstructive pulmonary disease (HP:0006510)3.43968505
28Recurrent skin infections (HP:0001581)3.41314726
29Hypertensive crisis (HP:0100735)3.37925059
30Meningitis (HP:0001287)3.36234863
31Hypochromic microcytic anemia (HP:0004840)3.27788267
32Petechiae (HP:0000967)3.17031578
33Keratoconjunctivitis sicca (HP:0001097)3.15412032
34Pulmonary infiltrates (HP:0002113)3.12713603
35Gingivitis (HP:0000230)3.11473803
36Microcytic anemia (HP:0001935)3.10857008
37Abnormality of T cell number (HP:0011839)3.09678016
38Cholelithiasis (HP:0001081)3.03401467
39Abnormal hemoglobin (HP:0011902)3.03178248
40Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.01076466
41Arterial thrombosis (HP:0004420)2.98819927
42Recurrent cutaneous fungal infections (HP:0011370)2.98718598
43Chronic mucocutaneous candidiasis (HP:0002728)2.98718598
44Abnormality of reticulocytes (HP:0004312)2.96127285
45Keratoconjunctivitis (HP:0001096)2.94334411
46Chronic otitis media (HP:0000389)2.93018528
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.92136785
48Leukocytosis (HP:0001974)2.87394780
49T lymphocytopenia (HP:0005403)2.87063173
50IgM deficiency (HP:0002850)2.86466334
51Abnormality of T cells (HP:0002843)2.80690883
52Acanthocytosis (HP:0001927)2.79214127
53Nasal polyposis (HP:0100582)2.76544619
54Periodontitis (HP:0000704)2.74428690
55Recurrent bronchitis (HP:0002837)2.73078180
56Increased serum ferritin (HP:0003281)2.72640354
57Prostate neoplasm (HP:0100787)2.72487586
58Thrombocytosis (HP:0001894)2.72144098
59Interstitial pulmonary disease (HP:0006530)2.67248877
60Abnormality of T cell physiology (HP:0011840)2.62857660
61Hemoptysis (HP:0002105)2.62570185
62Abnormality of iron homeostasis (HP:0011031)2.61029993
63Abnormal gallbladder morphology (HP:0012437)2.60743740
64Osteomyelitis (HP:0002754)2.60650268
65Hypergammaglobulinemia (HP:0010702)2.59387109
66Gastrointestinal infarctions (HP:0005244)2.58346188
67Increased IgE level (HP:0003212)2.58286131
68Agammaglobulinemia (HP:0004432)2.57142720
69Gingival bleeding (HP:0000225)2.56225025
70Urticaria (HP:0001025)2.54265184
71IgA deficiency (HP:0002720)2.53027728
72Slow saccadic eye movements (HP:0000514)2.52752258
73Eosinophilia (HP:0001880)2.51064417
74Encephalitis (HP:0002383)2.51032446
75Seborrheic dermatitis (HP:0001051)2.48469150
76Basal ganglia calcification (HP:0002135)2.47208027
77Prolonged bleeding time (HP:0003010)2.46541886
78Combined immunodeficiency (HP:0005387)2.46485320
79Ileus (HP:0002595)2.44615021
80Paralysis (HP:0003470)2.40848846
81Thyroiditis (HP:0100646)2.39286908
82Spontaneous hematomas (HP:0007420)2.38057766
83Abnormality of the nasal mucosa (HP:0000433)2.37941808
84Abnormality of the prostate (HP:0008775)2.34817116
85Abnormality of eosinophils (HP:0001879)2.34678604
86Granulocytopenia (HP:0001913)2.34198253
87Truncus arteriosus (HP:0001660)2.33208691
88Inflammation of the large intestine (HP:0002037)2.31922112
89Panhypogammaglobulinemia (HP:0003139)2.31161275
90Severe combined immunodeficiency (HP:0004430)2.31085987
91Epistaxis (HP:0000421)2.30335166
92Recurrent pneumonia (HP:0006532)2.29154336
93Vacuolated lymphocytes (HP:0001922)2.25522876
94IgG deficiency (HP:0004315)2.24442720
95Abnormality of glycolipid metabolism (HP:0010969)2.23753683
96Abnormality of liposaccharide metabolism (HP:0010968)2.23753683
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.23753683
98Colitis (HP:0002583)2.22923685
99Aplasia/Hypoplasia of the thymus (HP:0010515)2.21931848
100Gastrointestinal inflammation (HP:0004386)2.21464146
101Anorexia (HP:0002039)2.19502002
102Recurrent lower respiratory tract infections (HP:0002783)2.18448117
103Hypochromic anemia (HP:0001931)2.18089868
104Fatigue (HP:0012378)2.17920241
105Abnormality of transition element cation homeostasis (HP:0011030)2.17448851
106Abnormality of cells of the lymphoid lineage (HP:0012140)2.17343749
107Abnormality of the fingertips (HP:0001211)2.17326308
108Myocardial infarction (HP:0001658)2.10091498
109Autoimmune hemolytic anemia (HP:0001890)2.10078319
110Gangrene (HP:0100758)2.09537167
111Thick nail (HP:0001805)2.08936281
112Lymphopenia (HP:0001888)2.08764913
113Lymphoma (HP:0002665)2.07918258
114Abnormal large intestine physiology (HP:0012700)2.07811387
115Bowel incontinence (HP:0002607)2.07341595
116Skin ulcer (HP:0200042)2.06309640
117Segmental peripheral demyelination/remyelination (HP:0003481)2.05046136
118Systemic lupus erythematosus (HP:0002725)2.03580398
119Premature loss of primary teeth (HP:0006323)2.03551492
120Abnormality of the pleura (HP:0002103)2.03268749
121Osteolytic defects of the hand bones (HP:0009699)2.02739061
122Osteolytic defects of the phalanges of the hand (HP:0009771)2.02739061
123Abnormality of the gallbladder (HP:0005264)2.02471611
124Tetraparesis (HP:0002273)2.02402768
125Amaurosis fugax (HP:0100576)2.02360249
126Acne (HP:0001061)2.02216928
127Increased cerebral lipofuscin (HP:0011813)2.01746603
128Joint swelling (HP:0001386)2.01654661
129Abnormal platelet function (HP:0011869)2.00685088
130Impaired platelet aggregation (HP:0003540)2.00685088
131Purpura (HP:0000979)2.00139554
132Pallor (HP:0000980)1.99917423
133Spinal cord lesions (HP:0100561)1.97930733
134Syringomyelia (HP:0003396)1.97930733
135Glomerulopathy (HP:0100820)1.97694828
136Gastrointestinal stroma tumor (HP:0100723)1.96496266
137Sepsis (HP:0100806)1.95840408
138Hyperbilirubinemia (HP:0002904)1.91083548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.90528638
2PRPF4B3.60538087
3MAP4K13.60060056
4TXK3.41922373
5IRAK33.14201539
6IKBKB2.96562641
7TBK12.95860704
8IKBKE2.79494689
9JAK32.72038150
10IRAK42.67914484
11TYK22.45736415
12PIM22.45175267
13BLK2.36545337
14RIPK42.34701180
15TAOK22.27921049
16CHUK2.14825340
17KSR21.77206448
18ZAP701.71984018
19JAK11.70827254
20TAOK31.66986964
21MAP3K11.66254119
22* PIM11.64599070
23TAOK11.58669432
24BTK1.58502943
25SYK1.51570736
26NME21.49535876
27KIT1.46161717
28MST41.39992921
29STK101.39350681
30MAP3K101.37074849
31TEC1.36080157
32CDK121.33690627
33CSK1.30549198
34FGFR31.27712660
35STK41.26793700
36EPHB11.22542820
37EEF2K1.21865462
38HCK1.19965075
39LCK1.15711900
40MAP3K131.14808063
41RPS6KA41.12835804
42PBK1.05263751
43RAF11.03271904
44JAK21.02537649
45LYN1.02270261
46NEK91.01789111
47TRIB31.01332450
48TRPM70.99718268
49ITK0.99709158
50CSF1R0.98051355
51GRK60.97976898
52EPHA30.97969874
53ERN10.97039327
54BMPR20.96628699
55MAP3K20.95463551
56CLK10.95071165
57FGFR40.92971631
58MARK30.88742008
59MAP2K30.88593841
60STK240.87482510
61ICK0.83744742
62MATK0.83405009
63NLK0.79464993
64CDK60.77951789
65SIK30.76631255
66EIF2AK20.75959923
67TNK20.75553955
68YES10.73656797
69TGFBR20.73193737
70WNK10.72800988
71MAP3K110.70013562
72MAPKAPK20.68667692
73IRAK10.68560054
74MAP3K60.67571070
75MARK20.66853621
76IRAK20.65686476
77TESK20.64706105
78KSR10.64471533
79SMG10.63249622
80MAP3K70.63049725
81RPS6KA60.62804639
82STK30.60436318
83CDK40.59689187
84DYRK30.59550747
85RPS6KA50.59075799
86LRRK20.58270635
87ABL10.57252742
88CDC42BPA0.57042309
89MAPK110.56507712
90RPS6KA10.55199413
91PTK60.52066469
92CAMK1D0.51858789
93MAPK120.49372403
94RPS6KC10.49320170
95RPS6KL10.49320170
96ALK0.49118142
97ABL20.45545800
98RPS6KB20.45333821
99TYRO30.45332705
100FLT30.45262029
101SIK20.44577344
102PRKCD0.43848868
103MKNK20.42828743
104MAP3K30.42037372
105HIPK20.41839798
106EIF2AK10.40750229
107PDK10.40655574
108MAP3K50.40337994
109MOS0.40099018
110GRK70.39880444
111BRD40.38728189
112PLK40.38360500
113RET0.37714335
114RIPK10.36369833
115FGR0.35735845
116SIK10.35060564
117TGFBR10.34889284
118PRKCQ0.34345157
119EGFR0.34235110
120MKNK10.33623715
121CDK90.32905899
122FES0.32235429
123MAP3K80.32216347
124MUSK0.31262037
125ACVR1B0.28481498
126NEK20.28237626
127ATR0.27563523
128TLK10.27063338
129DYRK1B0.27051723
130MAPK30.26078665

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.32910505
2Allograft rejection_Homo sapiens_hsa053303.00096002
3Leishmaniasis_Homo sapiens_hsa051402.92794002
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.88606716
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.64425539
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.52554866
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.39624091
8Measles_Homo sapiens_hsa051622.36719429
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.34026782
10Osteoclast differentiation_Homo sapiens_hsa043802.26780590
11Legionellosis_Homo sapiens_hsa051342.25637017
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.25396047
13Primary immunodeficiency_Homo sapiens_hsa053402.19215177
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.15826777
15Asthma_Homo sapiens_hsa053102.04236193
16TNF signaling pathway_Homo sapiens_hsa046681.86382234
17Malaria_Homo sapiens_hsa051441.83182986
18Herpes simplex infection_Homo sapiens_hsa051681.82803176
19Type I diabetes mellitus_Homo sapiens_hsa049401.82308158
20Influenza A_Homo sapiens_hsa051641.75865291
21Autoimmune thyroid disease_Homo sapiens_hsa053201.73235362
22B cell receptor signaling pathway_Homo sapiens_hsa046621.72557268
23Antigen processing and presentation_Homo sapiens_hsa046121.72236507
24Hematopoietic cell lineage_Homo sapiens_hsa046401.69118717
25* Jak-STAT signaling pathway_Homo sapiens_hsa046301.68136649
26Pertussis_Homo sapiens_hsa051331.65188786
27Staphylococcus aureus infection_Homo sapiens_hsa051501.61392912
28Toxoplasmosis_Homo sapiens_hsa051451.61321552
29Tuberculosis_Homo sapiens_hsa051521.59348510
30Apoptosis_Homo sapiens_hsa042101.57568809
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57150706
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.55658341
33Rheumatoid arthritis_Homo sapiens_hsa053231.47122649
34T cell receptor signaling pathway_Homo sapiens_hsa046601.39183625
35Salmonella infection_Homo sapiens_hsa051321.32046516
36Chemokine signaling pathway_Homo sapiens_hsa040621.30765363
37Hepatitis B_Homo sapiens_hsa051611.29718059
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28385486
39Shigellosis_Homo sapiens_hsa051311.25880694
40Viral myocarditis_Homo sapiens_hsa054161.19393907
41African trypanosomiasis_Homo sapiens_hsa051431.14921758
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06559442
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06461698
44Renal cell carcinoma_Homo sapiens_hsa052111.05610351
45* Acute myeloid leukemia_Homo sapiens_hsa052211.03366123
46Epstein-Barr virus infection_Homo sapiens_hsa051691.01113700
47Chronic myeloid leukemia_Homo sapiens_hsa052200.98809235
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97777968
49Hepatitis C_Homo sapiens_hsa051600.94302896
50* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92985075
51Prolactin signaling pathway_Homo sapiens_hsa049170.91053389
52p53 signaling pathway_Homo sapiens_hsa041150.91005036
53Bladder cancer_Homo sapiens_hsa052190.90158005
54mTOR signaling pathway_Homo sapiens_hsa041500.88139101
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.83307588
56Ribosome_Homo sapiens_hsa030100.80765706
57Viral carcinogenesis_Homo sapiens_hsa052030.79720431
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76404002
59Base excision repair_Homo sapiens_hsa034100.76321107
60Type II diabetes mellitus_Homo sapiens_hsa049300.76221059
61HTLV-I infection_Homo sapiens_hsa051660.75110659
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74744952
63Small cell lung cancer_Homo sapiens_hsa052220.74035602
64DNA replication_Homo sapiens_hsa030300.71343725
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69598771
66Thyroid cancer_Homo sapiens_hsa052160.66449782
67Phagosome_Homo sapiens_hsa041450.66303403
68Platelet activation_Homo sapiens_hsa046110.65972707
69Pancreatic cancer_Homo sapiens_hsa052120.65796426
70Endometrial cancer_Homo sapiens_hsa052130.63003186
71ErbB signaling pathway_Homo sapiens_hsa040120.61622474
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.59757681
73Other glycan degradation_Homo sapiens_hsa005110.57547084
74Lysosome_Homo sapiens_hsa041420.55410296
75Notch signaling pathway_Homo sapiens_hsa043300.55349976
76Fructose and mannose metabolism_Homo sapiens_hsa000510.54266571
77HIF-1 signaling pathway_Homo sapiens_hsa040660.52902074
78Amoebiasis_Homo sapiens_hsa051460.52215699
79Homologous recombination_Homo sapiens_hsa034400.51688346
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51523992
81Colorectal cancer_Homo sapiens_hsa052100.49321299
82Insulin signaling pathway_Homo sapiens_hsa049100.49118646
83Inositol phosphate metabolism_Homo sapiens_hsa005620.48140510
84Choline metabolism in cancer_Homo sapiens_hsa052310.47949754
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47017907
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45876520
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45857120
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.45784216
89FoxO signaling pathway_Homo sapiens_hsa040680.45331479
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.45066442
91* MicroRNAs in cancer_Homo sapiens_hsa052060.44585793
92Glioma_Homo sapiens_hsa052140.43608223
93Mismatch repair_Homo sapiens_hsa034300.43221585
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42603418
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40636795
96Pentose phosphate pathway_Homo sapiens_hsa000300.39694589
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39668531
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39608864
99Systemic lupus erythematosus_Homo sapiens_hsa053220.39571274
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39384969
101Spliceosome_Homo sapiens_hsa030400.39313920
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38926097
103One carbon pool by folate_Homo sapiens_hsa006700.33946145
104Fanconi anemia pathway_Homo sapiens_hsa034600.33466937
105Prostate cancer_Homo sapiens_hsa052150.33154180
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32052953
107VEGF signaling pathway_Homo sapiens_hsa043700.31117559
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30076106
109Non-small cell lung cancer_Homo sapiens_hsa052230.29710362
110RNA degradation_Homo sapiens_hsa030180.29697517
111Cell cycle_Homo sapiens_hsa041100.28631217
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25753514
113MAPK signaling pathway_Homo sapiens_hsa040100.25486186
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.24913569
115Dorso-ventral axis formation_Homo sapiens_hsa043200.24888452
116Proteasome_Homo sapiens_hsa030500.24883804
117Prion diseases_Homo sapiens_hsa050200.24467128
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.24228122
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24175877
120Proteoglycans in cancer_Homo sapiens_hsa052050.24026681
121Insulin resistance_Homo sapiens_hsa049310.23746115

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