PIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.78007910
2proline biosynthetic process (GO:0006561)5.90166496
3synaptic vesicle maturation (GO:0016188)5.48800780
4transcription from mitochondrial promoter (GO:0006390)5.00413784
5synaptic vesicle exocytosis (GO:0016079)4.99097666
6viral mRNA export from host cell nucleus (GO:0046784)4.95475220
7formation of translation preinitiation complex (GO:0001731)4.90162135
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.82413828
9cullin deneddylation (GO:0010388)4.76834312
10deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.74788040
11telomere maintenance via semi-conservative replication (GO:0032201)4.68132235
12replication fork processing (GO:0031297)4.66351297
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.64552958
14maturation of 5.8S rRNA (GO:0000460)4.58715588
15proteasome assembly (GO:0043248)4.58179081
16glutamate secretion (GO:0014047)4.54124556
17chaperone-mediated protein transport (GO:0072321)4.46589500
18DNA strand elongation involved in DNA replication (GO:0006271)4.34302691
19regulation of synaptic vesicle exocytosis (GO:2000300)4.34057755
20protein deneddylation (GO:0000338)4.33949345
21maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.27019374
22proline metabolic process (GO:0006560)4.24301367
23metallo-sulfur cluster assembly (GO:0031163)4.21319609
24iron-sulfur cluster assembly (GO:0016226)4.21319609
25somatic hypermutation of immunoglobulin genes (GO:0016446)4.21228078
26somatic diversification of immune receptors via somatic mutation (GO:0002566)4.21228078
27DNA strand elongation (GO:0022616)4.08561858
28spliceosomal snRNP assembly (GO:0000387)4.08146392
29regulation of synaptic vesicle transport (GO:1902803)3.99996854
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.96384899
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.94987175
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.91728778
33telomere maintenance via recombination (GO:0000722)3.87596550
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84554636
35ribosomal large subunit biogenesis (GO:0042273)3.83706135
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.81023714
37ATP synthesis coupled proton transport (GO:0015986)3.78405226
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.78405226
39positive regulation of synapse maturation (GO:0090129)3.77265955
40viral transcription (GO:0019083)3.70235157
41histone arginine methylation (GO:0034969)3.67987751
42pseudouridine synthesis (GO:0001522)3.66062716
43oxidative demethylation (GO:0070989)3.65608823
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64863693
45translational termination (GO:0006415)3.60859463
46translational initiation (GO:0006413)3.59488321
47regulation of double-strand break repair via homologous recombination (GO:0010569)3.56918279
48mitochondrial DNA metabolic process (GO:0032042)3.56414851
49respiratory electron transport chain (GO:0022904)3.55585500
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.55492101
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.53802811
52kinetochore assembly (GO:0051382)3.52313296
53DNA strand renaturation (GO:0000733)3.50329046
54termination of RNA polymerase II transcription (GO:0006369)3.49755115
55electron transport chain (GO:0022900)3.49348196
56ribosome biogenesis (GO:0042254)3.49245124
57DNA integration (GO:0015074)3.49038485
58protein neddylation (GO:0045116)3.48696613
59neurotransmitter secretion (GO:0007269)3.47643676
602-deoxyribonucleotide biosynthetic process (GO:0009265)3.46921357
61deoxyribose phosphate biosynthetic process (GO:0046385)3.46921357
62base-excision repair (GO:0006284)3.46835974
63establishment of mitochondrion localization (GO:0051654)3.45955146
64maturation of SSU-rRNA (GO:0030490)3.45887997
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.45228617
66positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43682010
67telomere maintenance via telomere lengthening (GO:0010833)3.43514206
68ribonucleoprotein complex biogenesis (GO:0022613)3.43207538
69mitotic recombination (GO:0006312)3.41228805
70rRNA processing (GO:0006364)3.40898833
71protein maturation by protein folding (GO:0022417)3.39717829
72behavioral response to nicotine (GO:0035095)3.38628162
73translational elongation (GO:0006414)3.38587869
74GTP biosynthetic process (GO:0006183)3.38311123
75peptidyl-arginine omega-N-methylation (GO:0035247)3.34476213
76embryonic process involved in female pregnancy (GO:0060136)3.33877972
77protein complex biogenesis (GO:0070271)3.33317397
78GDP-mannose metabolic process (GO:0019673)3.33258216
79base-excision repair, AP site formation (GO:0006285)3.33163316
80response to misfolded protein (GO:0051788)3.32564372
81positive regulation of protein homooligomerization (GO:0032464)3.32263360
82locomotory exploration behavior (GO:0035641)3.31668082
83transcription-coupled nucleotide-excision repair (GO:0006283)3.30527140
84establishment of protein localization to mitochondrion (GO:0072655)3.29157627
85establishment of apical/basal cell polarity (GO:0035089)3.28683504
86protein targeting to mitochondrion (GO:0006626)3.27940777
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26404722
88rRNA metabolic process (GO:0016072)3.26236304
89DNA double-strand break processing (GO:0000729)3.25894567
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24849624
91membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23622607
92mitotic G1 DNA damage checkpoint (GO:0031571)3.23370349
93negative regulation of ligase activity (GO:0051352)3.21065455
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21065455
95DNA replication initiation (GO:0006270)3.19631321
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.18733776
97pyrimidine nucleotide catabolic process (GO:0006244)3.17422192
98neuronal ion channel clustering (GO:0045161)3.16337225
99DNA replication checkpoint (GO:0000076)3.15495601
100protein localization to synapse (GO:0035418)3.14830793
101synaptic transmission, glutamatergic (GO:0035249)3.14566825
102ribosomal small subunit assembly (GO:0000028)3.14211942
103regulation of synapse structural plasticity (GO:0051823)3.13747413
104ribosomal small subunit biogenesis (GO:0042274)3.13667612
105deoxyribonucleotide catabolic process (GO:0009264)3.13102548
106mitochondrial respiratory chain complex I assembly (GO:0032981)3.12063807
107NADH dehydrogenase complex assembly (GO:0010257)3.12063807
108mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12063807
109translation (GO:0006412)3.10711760
110mitochondrial RNA metabolic process (GO:0000959)3.10360184
111establishment of monopolar cell polarity (GO:0061162)3.10187342
112establishment or maintenance of monopolar cell polarity (GO:0061339)3.10187342
113regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.09789998
114kinetochore organization (GO:0051383)3.09356776
115transcription elongation from RNA polymerase III promoter (GO:0006385)3.08980273
116termination of RNA polymerase III transcription (GO:0006386)3.08980273
117spliceosomal complex assembly (GO:0000245)3.07334781
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.07034660
119SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05791441
120negative regulation of cell cycle arrest (GO:0071157)3.05496081
121negative regulation of mRNA processing (GO:0050686)3.05175544
122DNA ligation (GO:0006266)3.03611229
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01346711
124signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01346711
125mitochondrial respiratory chain complex assembly (GO:0033108)3.01325254
126guanosine-containing compound biosynthetic process (GO:1901070)3.00654046
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00129148
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00129148
129signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00129148
130regulation of mitochondrial translation (GO:0070129)3.00085132
131signal transduction involved in DNA damage checkpoint (GO:0072422)2.99675714
132signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99675714
133exploration behavior (GO:0035640)2.99658473
134nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.99503819
135cotranslational protein targeting to membrane (GO:0006613)2.99189090
136mitochondrion transport along microtubule (GO:0047497)2.98724105
137establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.98724105
138spliceosomal tri-snRNP complex assembly (GO:0000244)2.98707239
139UTP biosynthetic process (GO:0006228)2.98615807
140protein targeting to ER (GO:0045047)2.97470422
141positive regulation of membrane potential (GO:0045838)2.97068812
142signal transduction involved in cell cycle checkpoint (GO:0072395)2.96193098
143negative regulation of RNA splicing (GO:0033119)2.95738617
144viral life cycle (GO:0019058)2.95332629
145cellular protein complex disassembly (GO:0043624)2.95158029
146pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93995326
147nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92875639
148protein insertion into membrane (GO:0051205)2.92173179
149cellular component biogenesis (GO:0044085)2.91479619
150regulation of synapse maturation (GO:0090128)2.88604013
151positive regulation of neurotransmitter transport (GO:0051590)2.84867909
1522-deoxyribonucleotide metabolic process (GO:0009394)2.84114952
153postsynaptic membrane organization (GO:0001941)2.83376189
154dendritic spine organization (GO:0097061)2.82868364
155purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.81666686
156energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.81241776
157ATP hydrolysis coupled proton transport (GO:0015991)2.81241776
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.79904686
159purine deoxyribonucleotide catabolic process (GO:0009155)2.77639478
160deoxyribose phosphate catabolic process (GO:0046386)2.77438196
161regulation of voltage-gated calcium channel activity (GO:1901385)2.76436814
162purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73802549
163regulation of neuronal synaptic plasticity (GO:0048168)2.70305054
164negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.69793316
165pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69165141
166regulation of neurotransmitter levels (GO:0001505)2.68632828
167regulation of glutamate receptor signaling pathway (GO:1900449)2.67774544
168UTP metabolic process (GO:0046051)2.66852936
169regulation of neurotransmitter secretion (GO:0046928)2.65661798
170positive regulation of neurotransmitter secretion (GO:0001956)2.65654594
171pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65294688
172purine deoxyribonucleotide metabolic process (GO:0009151)2.63875715
173ATP biosynthetic process (GO:0006754)2.63778969
174CTP metabolic process (GO:0046036)2.62513967
175CTP biosynthetic process (GO:0006241)2.62513967
176hydrogen ion transmembrane transport (GO:1902600)2.62338693
177cell migration in hindbrain (GO:0021535)2.61676024
178neuron-neuron synaptic transmission (GO:0007270)2.61324501
179deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.60224931
180negative regulation of DNA-templated transcription, elongation (GO:0032785)2.59940147
181regulation of cellular respiration (GO:0043457)2.58854010
182ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.57013041
183cellular potassium ion homeostasis (GO:0030007)2.55842350
184ribonucleoside triphosphate biosynthetic process (GO:0009201)2.55510898
185neurotransmitter transport (GO:0006836)2.53719338
186negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53087914
187mitochondrial calcium ion transport (GO:0006851)2.52252019
188regulation of dopamine metabolic process (GO:0042053)2.50930123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.69627303
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.38717748
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.76840918
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54107707
5MYC_18358816_ChIP-ChIP_MESCs_Mouse3.26776919
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21859097
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.20791991
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19958767
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.98620631
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96971539
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.96603227
12EZH2_22144423_ChIP-Seq_EOC_Human2.85189570
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83560874
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59404011
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.58349348
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56670319
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53282791
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42968616
19XRN2_22483619_ChIP-Seq_HELA_Human2.34024379
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32378804
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31729915
22LXR_22292898_ChIP-Seq_THP-1_Human2.30403600
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.28641505
24DCP1A_22483619_ChIP-Seq_HELA_Human2.28033187
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26776722
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.23693791
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.22915298
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.20600748
29P68_20966046_ChIP-Seq_HELA_Human2.19165704
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.18473908
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12597529
32GABP_19822575_ChIP-Seq_HepG2_Human2.05805848
33ELF1_20517297_ChIP-Seq_JURKAT_Human2.02678713
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00325038
35VDR_23849224_ChIP-Seq_CD4+_Human1.99886566
36TTF2_22483619_ChIP-Seq_HELA_Human1.99737151
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99484630
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.98798725
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.96219915
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92898923
41BCL6_27268052_Chip-Seq_Bcells_Human1.92204964
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87000351
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82129800
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.78675072
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77298932
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77298932
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77298932
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76579878
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.76436822
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76155295
51CTCF_27219007_Chip-Seq_Bcells_Human1.74793058
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73492323
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70538640
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70041266
55KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68652273
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64604861
57FOXP3_21729870_ChIP-Seq_TREG_Human1.64436296
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64330174
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62427798
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.62391687
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58622532
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56509481
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.56105339
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.55827550
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.54647136
66BCOR_27268052_Chip-Seq_Bcells_Human1.53796555
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52500837
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50260746
69* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.50188346
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.49639473
71CTCF_20526341_ChIP-Seq_ESCs_Human1.48508948
72SA1_27219007_Chip-Seq_Bcells_Human1.48191915
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47562601
74PHF8_20622854_ChIP-Seq_HELA_Human1.46893367
75SMC4_20622854_ChIP-Seq_HELA_Human1.46266722
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.45123766
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.44905069
78ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44733060
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44057707
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43528252
81E2F1_20622854_ChIP-Seq_HELA_Human1.43285282
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41290399
83REST_21632747_ChIP-Seq_MESCs_Mouse1.40894085
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40415259
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.38558667
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38330016
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37531698
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36019533
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.35782289
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35526559
91KDM5A_27292631_Chip-Seq_BREAST_Human1.34128502
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33515212
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.33385757
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32712671
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32046692
96CTCF_26484167_Chip-Seq_Bcells_Mouse1.31832908
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31611094
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31366248
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30696817
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30206849
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29943964
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29398305
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29117038
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28136933
105TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27383617
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25648077
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24228884
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.23637067
109VDR_21846776_ChIP-Seq_THP-1_Human1.23490455
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22761877
111* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22745521
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21775687
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.21724649
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21565412
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21411999
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19541184
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18711143
118* E2F1_21310950_ChIP-Seq_MCF-7_Human1.18577662
119SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17453005
120JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15913943
121TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15607097
122OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15047073
123TET1_21451524_ChIP-Seq_MESCs_Mouse1.15035755
124POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15008821
125ELK1_19687146_ChIP-ChIP_HELA_Human1.14949079
126* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14245602
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13992375
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13243154
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13012448
130YY1_22570637_ChIP-Seq_MALME-3M_Human1.12140167
131KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10339205
132MAF_26560356_Chip-Seq_TH2_Human1.10287882
133POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09927863
134RARA_24833708_ChIP-Seq_LIVER_Mouse1.07628733
135TFEB_21752829_ChIP-Seq_HELA_Human1.07113433
136ETS1_21867929_ChIP-Seq_TH2_Mouse1.07065283
137KDM2B_26808549_Chip-Seq_DND41_Human1.07029933
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07026747
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06070372
140DROSHA_22980978_ChIP-Seq_HELA_Human1.05845441
141CTCF_21964334_Chip-Seq_Bcells_Human1.04239755
142SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04044619
143ELK3_25401928_ChIP-Seq_HUVEC_Human1.03507636
144FOXP1_21924763_ChIP-Seq_HESCs_Human1.03465536
145ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03319443
146* RARB_24833708_ChIP-Seq_LIVER_Mouse1.02868070
147JARID2_20064375_ChIP-Seq_MESCs_Mouse1.02863490
148OCT4_19829295_ChIP-Seq_ESCs_Human1.02111982
149CIITA_25753668_ChIP-Seq_RAJI_Human1.01212948
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01013433
151UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00913623
152P300_27268052_Chip-Seq_Bcells_Human1.00379087
153PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00359220
154ERA_21632823_ChIP-Seq_H3396_Human0.98083787
155TAF2_19829295_ChIP-Seq_ESCs_Human0.97491440
156ELK1_22589737_ChIP-Seq_MCF10A_Human0.96655731
157ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93769767
158CTCF_18555785_ChIP-Seq_MESCs_Mouse0.92636296
159SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92334466
160TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92106948
161PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90359109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46112271
2MP0008057_abnormal_DNA_replication4.73169114
3MP0003880_abnormal_central_pattern4.37694032
4MP0003693_abnormal_embryo_hatching3.75560814
5MP0010030_abnormal_orbit_morphology3.67067870
6MP0004957_abnormal_blastocyst_morpholog3.65221013
7MP0010094_abnormal_chromosome_stability3.54842146
8MP0003111_abnormal_nucleus_morphology3.28735555
9MP0003635_abnormal_synaptic_transmissio3.09345734
10MP0008932_abnormal_embryonic_tissue3.07163810
11MP0005423_abnormal_somatic_nervous3.01743246
12MP0005171_absent_coat_pigmentation2.96536089
13MP0008058_abnormal_DNA_repair2.92766225
14MP0001968_abnormal_touch/_nociception2.88700315
15MP0002064_seizures2.81115546
16MP0004133_heterotaxia2.77932615
17MP0003077_abnormal_cell_cycle2.76760598
18MP0009745_abnormal_behavioral_response2.73686451
19MP0009046_muscle_twitch2.48537026
20MP0002063_abnormal_learning/memory/cond2.47357540
21MP0003786_premature_aging2.46194116
22MP0003329_amyloid_beta_deposits2.39613453
23MP0002272_abnormal_nervous_system2.37721191
24MP0004233_abnormal_muscle_weight2.26181160
25MP0002736_abnormal_nociception_after2.25751679
26MP0002653_abnormal_ependyma_morphology2.24554712
27MP0001905_abnormal_dopamine_level2.21217676
28MP0002572_abnormal_emotion/affect_behav2.19177848
29MP0003787_abnormal_imprinting2.15612462
30MP0002734_abnormal_mechanical_nocicepti2.13974508
31MP0006276_abnormal_autonomic_nervous2.13960160
32MP0003119_abnormal_digestive_system2.13531456
33MP0003890_abnormal_embryonic-extraembry2.13224385
34MP0004270_analgesia2.13091929
35MP0008877_abnormal_DNA_methylation2.11544762
36MP0001970_abnormal_pain_threshold2.00509435
37MP0009278_abnormal_bone_marrow1.78998934
38MP0001730_embryonic_growth_arrest1.78678797
39MP0001697_abnormal_embryo_size1.77704475
40MP0003283_abnormal_digestive_organ1.74617285
41MP0001486_abnormal_startle_reflex1.73683000
42MP0003718_maternal_effect1.69686438
43MP0006072_abnormal_retinal_apoptosis1.64809189
44MP0008995_early_reproductive_senescence1.61718697
45MP0002735_abnormal_chemical_nociception1.61109789
46MP0000350_abnormal_cell_proliferation1.60527588
47MP0008569_lethality_at_weaning1.60507727
48MP0002085_abnormal_embryonic_tissue1.59457223
49MP0002751_abnormal_autonomic_nervous1.57109819
50MP0008007_abnormal_cellular_replicative1.55070083
51MP0002557_abnormal_social/conspecific_i1.52002035
52MP0002084_abnormal_developmental_patter1.49183553
53MP0004811_abnormal_neuron_physiology1.48745820
54MP0003879_abnormal_hair_cell1.45184553
55MP0002067_abnormal_sensory_capabilities1.41858756
56MP0005380_embryogenesis_phenotype1.39833781
57MP0001672_abnormal_embryogenesis/_devel1.39833781
58MP0004147_increased_porphyrin_level1.39709716
59MP0002822_catalepsy1.39282357
60MP0003567_abnormal_fetal_cardiomyocyte1.38376053
61MP0001293_anophthalmia1.38347947
62MP0003123_paternal_imprinting1.35804428
63MP0002638_abnormal_pupillary_reflex1.34769747
64MP0002080_prenatal_lethality1.33872451
65MP0002009_preneoplasia1.29049744
66MP0001501_abnormal_sleep_pattern1.28457951
67MP0004742_abnormal_vestibular_system1.28164909
68MP0000490_abnormal_crypts_of1.27534168
69MP0006292_abnormal_olfactory_placode1.24461747
70MP0003806_abnormal_nucleotide_metabolis1.24450648
71MP0001986_abnormal_taste_sensitivity1.24325679
72MP0000049_abnormal_middle_ear1.23726225
73MP0001984_abnormal_olfaction1.23355261
74MP0001502_abnormal_circadian_rhythm1.22424491
75MP0000955_abnormal_spinal_cord1.22310046
76MP0002882_abnormal_neuron_morphology1.21985079
77MP0002249_abnormal_larynx_morphology1.21967081
78MP0004142_abnormal_muscle_tone1.20821161
79MP0002086_abnormal_extraembryonic_tissu1.20062124
80MP0003646_muscle_fatigue1.20046176
81MP0000778_abnormal_nervous_system1.19700781
82MP0002066_abnormal_motor_capabilities/c1.19038954
83MP0004197_abnormal_fetal_growth/weight/1.18029652
84MP0005410_abnormal_fertilization1.17310365
85MP0001188_hyperpigmentation1.15714491
86MP0002269_muscular_atrophy1.14956402
87MP0002111_abnormal_tail_morphology1.14293914
88MP0000313_abnormal_cell_death1.14215524
89MP0000015_abnormal_ear_pigmentation1.12126601
90MP0002234_abnormal_pharynx_morphology1.11609443
91MP0003984_embryonic_growth_retardation1.10904908
92MP0000604_amyloidosis1.10482555
93MP0005397_hematopoietic_system_phenotyp1.10415647
94MP0001545_abnormal_hematopoietic_system1.10415647
95MP0005174_abnormal_tail_pigmentation1.08499530
96MP0001440_abnormal_grooming_behavior1.07418470
97MP0002088_abnormal_embryonic_growth/wei1.06364180
98MP0005075_abnormal_melanosome_morpholog1.03671212
99MP0003122_maternal_imprinting1.01205405
100MP0002282_abnormal_trachea_morphology1.01010774
101MP0002229_neurodegeneration1.00132153
102MP0002160_abnormal_reproductive_system0.97439076
103MP0000358_abnormal_cell_content/0.96381143
104MP0002019_abnormal_tumor_incidence0.95757100
105MP0002210_abnormal_sex_determination0.94659239
106* MP0001145_abnormal_male_reproductive0.93772755
107MP0000681_abnormal_thyroid_gland0.92803793
108MP0005266_abnormal_metabolism0.92424942
109MP0008874_decreased_physiological_sensi0.92213825
110MP0001963_abnormal_hearing_physiology0.92153861
111MP0006036_abnormal_mitochondrial_physio0.91791855
112MP0001727_abnormal_embryo_implantation0.91744278
113MP0005646_abnormal_pituitary_gland0.90812176
114MP0003137_abnormal_impulse_conducting0.88961443
115MP0002114_abnormal_axial_skeleton0.88714823
116MP0000762_abnormal_tongue_morphology0.88001737
117MP0005386_behavior/neurological_phenoty0.87882860
118MP0004924_abnormal_behavior0.87882860
119MP0003136_yellow_coat_color0.87681621
120MP0005670_abnormal_white_adipose0.86912871
121MP0003315_abnormal_perineum_morphology0.86626793
122MP0001348_abnormal_lacrimal_gland0.86259448
123MP0005551_abnormal_eye_electrophysiolog0.85933158
124MP0002152_abnormal_brain_morphology0.85661308
125MP0008872_abnormal_physiological_respon0.85634085
126MP0003075_altered_response_to0.85267489
127MP0003755_abnormal_palate_morphology0.84951166
128MP0009379_abnormal_foot_pigmentation0.83999247
129MP0002932_abnormal_joint_morphology0.82313570
130MP0002184_abnormal_innervation0.82204010
131MP0000462_abnormal_digestive_system0.81967698
132MP0000470_abnormal_stomach_morphology0.81607414
133MP0003633_abnormal_nervous_system0.81097078
134MP0004130_abnormal_muscle_cell0.81093044
135MP0009333_abnormal_splenocyte_physiolog0.81057196
136MP0003861_abnormal_nervous_system0.81056670
137MP0003121_genomic_imprinting0.79818557
138MP0008789_abnormal_olfactory_epithelium0.78359516
139MP0002752_abnormal_somatic_nervous0.76646054
140MP0005058_abnormal_lysosome_morphology0.76605834
141MP0005623_abnormal_meninges_morphology0.76010251
142MP0003941_abnormal_skin_development0.75933579
143MP0003631_nervous_system_phenotype0.75695169
144MP0002332_abnormal_exercise_endurance0.75384794
145MP0003698_abnormal_male_reproductive0.74814785
146MP0001529_abnormal_vocalization0.71658629
147MP0005671_abnormal_response_to0.70981141
148MP0003942_abnormal_urinary_system0.70948370
149MP0006035_abnormal_mitochondrial_morpho0.70808080
150MP0002116_abnormal_craniofacial_bone0.69858567
151MP0005645_abnormal_hypothalamus_physiol0.69516560
152MP0005377_hearing/vestibular/ear_phenot0.69473794
153MP0003878_abnormal_ear_physiology0.69473794
154MP0002163_abnormal_gland_morphology0.68149607
155MP0002132_abnormal_respiratory_system0.67312314
156MP0000920_abnormal_myelination0.66949335
157MP0005253_abnormal_eye_physiology0.66806306
158* MP0000653_abnormal_sex_gland0.66742870
159MP0000678_abnormal_parathyroid_gland0.66283625
160MP0003935_abnormal_craniofacial_develop0.65412429
161MP0003938_abnormal_ear_development0.65075909
162MP0002069_abnormal_eating/drinking_beha0.64834203
163MP0005535_abnormal_body_temperature0.64803073
164MP0010352_gastrointestinal_tract_polyps0.64390402
165MP0004145_abnormal_muscle_electrophysio0.64228473
166MP0005499_abnormal_olfactory_system0.62554349
167MP0005394_taste/olfaction_phenotype0.62554349
168MP0000751_myopathy0.62275707
169* MP0001929_abnormal_gametogenesis0.62091844
170MP0000372_irregular_coat_pigmentation0.61800857
171MP0005076_abnormal_cell_differentiation0.60222589
172MP0003385_abnormal_body_wall0.59594367
173MP0005330_cardiomyopathy0.58564547
174MP0001340_abnormal_eyelid_morphology0.58520179
175MP0002733_abnormal_thermal_nociception0.58251874
176MP0001485_abnormal_pinna_reflex0.57806369
177MP0009053_abnormal_anal_canal0.57146296

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.03900582
2Concave nail (HP:0001598)4.26029450
3Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.96414129
4Visual hallucinations (HP:0002367)3.92408973
5Rectovaginal fistula (HP:0000143)3.69845530
6Rectal fistula (HP:0100590)3.69845530
7Rib fusion (HP:0000902)3.65371254
8Focal motor seizures (HP:0011153)3.65094479
9Absent radius (HP:0003974)3.64475180
10Cerebral hypomyelination (HP:0006808)3.52933549
11Patellar aplasia (HP:0006443)3.46811492
12Increased intramyocellular lipid droplets (HP:0012240)3.43337407
13Aplasia involving forearm bones (HP:0009822)3.42675644
14Absent forearm bone (HP:0003953)3.42675644
15Breast hypoplasia (HP:0003187)3.38861297
16Absent thumb (HP:0009777)3.36455607
17Progressive microcephaly (HP:0000253)3.35907443
18Aplasia/Hypoplasia of the patella (HP:0006498)3.31861752
19Increased muscle lipid content (HP:0009058)3.23715638
20Tongue fasciculations (HP:0001308)3.20507738
21Annular pancreas (HP:0001734)3.19315923
22Reticulocytopenia (HP:0001896)3.12949511
23Aplasia/Hypoplasia of the sacrum (HP:0008517)3.12347689
24Intestinal fistula (HP:0100819)3.05488954
25Premature graying of hair (HP:0002216)3.02090362
26Vaginal fistula (HP:0004320)3.01495513
27Acute necrotizing encephalopathy (HP:0006965)2.97748863
28Epileptic encephalopathy (HP:0200134)2.96986002
29Exertional dyspnea (HP:0002875)2.95843881
30Aplasia/hypoplasia of the humerus (HP:0006507)2.94549572
31Muscle fibrillation (HP:0010546)2.88271593
32Focal seizures (HP:0007359)2.85111858
33Facial hemangioma (HP:0000329)2.84420792
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.84392169
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.84392169
36Abnormal hemoglobin (HP:0011902)2.83079542
37Abnormality of cells of the erythroid lineage (HP:0012130)2.82178845
38Cerebral palsy (HP:0100021)2.81938820
39Mitochondrial inheritance (HP:0001427)2.81255241
40Ankle clonus (HP:0011448)2.80222131
41Supranuclear gaze palsy (HP:0000605)2.78172858
42Increased IgM level (HP:0003496)2.75742817
43Abnormal number of erythroid precursors (HP:0012131)2.74646474
44Abnormality of the labia minora (HP:0012880)2.73768737
45Abnormal mitochondria in muscle tissue (HP:0008316)2.71065788
46Hepatocellular necrosis (HP:0001404)2.69691225
47Poikiloderma (HP:0001029)2.69114699
48Selective tooth agenesis (HP:0001592)2.67755135
49Intestinal atresia (HP:0011100)2.62161767
50Orthostatic hypotension (HP:0001278)2.61463222
51Degeneration of anterior horn cells (HP:0002398)2.61458992
52Abnormality of the anterior horn cell (HP:0006802)2.61458992
53Birth length less than 3rd percentile (HP:0003561)2.59139097
54Lactic acidosis (HP:0003128)2.57540257
55Hyperthyroidism (HP:0000836)2.56737148
56Abnormality of the ileum (HP:0001549)2.56103454
57Abnormal eating behavior (HP:0100738)2.52820881
58Increased CSF lactate (HP:0002490)2.50663480
59Abnormality of binocular vision (HP:0011514)2.48329729
60Diplopia (HP:0000651)2.48329729
61Abnormality of the aortic arch (HP:0012303)2.47943967
62Rough bone trabeculation (HP:0100670)2.46134000
63Delusions (HP:0000746)2.45344780
64Polyphagia (HP:0002591)2.44800238
65Increased serum lactate (HP:0002151)2.44646007
66Carpal bone hypoplasia (HP:0001498)2.42419868
67Premature ovarian failure (HP:0008209)2.40494765
68Short humerus (HP:0005792)2.40253275
69Focal dystonia (HP:0004373)2.40186397
70Hypoplasia of the radius (HP:0002984)2.40139343
71Amblyopia (HP:0000646)2.38063355
72Retinal dysplasia (HP:0007973)2.36103107
73Cerebral edema (HP:0002181)2.31682814
74Microretrognathia (HP:0000308)2.30746829
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30585449
76Opisthotonus (HP:0002179)2.26472975
77Emotional lability (HP:0000712)2.24830289
78Truncus arteriosus (HP:0001660)2.23659827
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22699970
80CNS hypomyelination (HP:0003429)2.22463870
81Acute encephalopathy (HP:0006846)2.20825799
82Limb dystonia (HP:0002451)2.20623697
83Dysautonomia (HP:0002459)2.20277594
84Testicular atrophy (HP:0000029)2.19421220
85Craniofacial dystonia (HP:0012179)2.19411282
86Basal cell carcinoma (HP:0002671)2.19238930
87Aplasia/Hypoplasia involving the musculature (HP:0001460)2.18179852
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.17953687
89Broad distal phalanx of finger (HP:0009836)2.17811000
90Ragged-red muscle fibers (HP:0003200)2.17761257
91Torticollis (HP:0000473)2.16361314
92Increased hepatocellular lipid droplets (HP:0006565)2.16273031
93Renal Fanconi syndrome (HP:0001994)2.15581820
94Squamous cell carcinoma (HP:0002860)2.15309206
95Oral leukoplakia (HP:0002745)2.15218022
96Muscle fiber atrophy (HP:0100295)2.13656609
97Trismus (HP:0000211)2.13378699
98Abnormal number of incisors (HP:0011064)2.11512744
99Supernumerary spleens (HP:0009799)2.11496525
100Exercise intolerance (HP:0003546)2.10973311
101Spastic gait (HP:0002064)2.10866247
102Progressive macrocephaly (HP:0004481)2.10816858
103Redundant skin (HP:0001582)2.09835446
104Type 2 muscle fiber atrophy (HP:0003554)2.09033497
105Hepatic necrosis (HP:0002605)2.08682612
106Abnormality of abdominal situs (HP:0011620)2.06348304
107Abdominal situs inversus (HP:0003363)2.06348304
108Unsteady gait (HP:0002317)2.05409125
109Optic disc pallor (HP:0000543)2.05079943
110Amniotic constriction ring (HP:0009775)2.04771371
111Abnormality of placental membranes (HP:0011409)2.04771371
112Macrocytic anemia (HP:0001972)2.04044551
113Failure to thrive in infancy (HP:0001531)2.01512203
1143-Methylglutaconic aciduria (HP:0003535)1.99447186
115Horseshoe kidney (HP:0000085)1.98614962
116Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.97842725
117Vertebral hypoplasia (HP:0008417)1.97842725
118Ependymoma (HP:0002888)1.97279713
119Lipid accumulation in hepatocytes (HP:0006561)1.97211788
120Congenital hip dislocation (HP:0001374)1.96677344
121Mutism (HP:0002300)1.94571105
122Meckel diverticulum (HP:0002245)1.94468804
123Broad alveolar ridges (HP:0000187)1.93876569
124Diaphragmatic weakness (HP:0009113)1.93112900
125Bifid uvula (HP:0000193)1.92759518
126Poor eye contact (HP:0000817)1.92339418
127Poor suck (HP:0002033)1.92265517
128Febrile seizures (HP:0002373)1.91326805
129Pustule (HP:0200039)1.90436348
130Leukodystrophy (HP:0002415)1.88091193
131Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87961264
132Atonic seizures (HP:0010819)1.87843986
133CNS demyelination (HP:0007305)1.86686729
134Tetraplegia (HP:0002445)1.86031687
135Pallor (HP:0000980)1.85773803
136Progressive external ophthalmoplegia (HP:0000590)1.85598140
137Severe global developmental delay (HP:0011344)1.85393957
138Generalized tonic-clonic seizures (HP:0002069)1.84664774
139Gliosis (HP:0002171)1.83992063
140Aplasia of the musculature (HP:0100854)1.83693788
141Status epilepticus (HP:0002133)1.83302167
142Respiratory failure (HP:0002878)1.82876376
143Secondary amenorrhea (HP:0000869)1.82295842
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81699784
145Myotonia (HP:0002486)1.79722880
146Alacrima (HP:0000522)1.79105719
147Dicarboxylic aciduria (HP:0003215)1.78619858
148Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78619858
149Neuronal loss in central nervous system (HP:0002529)1.78191567
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77935949
151Capillary hemangiomas (HP:0005306)1.77519045
152Short chin (HP:0000331)1.76472497
153Insomnia (HP:0100785)1.76464968
154Abnormality of the preputium (HP:0100587)1.75175513
155Triphalangeal thumb (HP:0001199)1.74534316
156Abnormal trabecular bone morphology (HP:0100671)1.74425373
157Type II lissencephaly (HP:0007260)1.74367569
158Spinal muscular atrophy (HP:0007269)1.74259064
159Postural instability (HP:0002172)1.73831222
160Absence seizures (HP:0002121)1.72455708
161Microvesicular hepatic steatosis (HP:0001414)1.71808533
162Agammaglobulinemia (HP:0004432)1.69818165
163Dysphonia (HP:0001618)1.69507521
164Depression (HP:0000716)1.67684713
165Bradykinesia (HP:0002067)1.66740521
166Spastic tetraparesis (HP:0001285)1.66318019
167Psychosis (HP:0000709)1.66002926
168Progressive cerebellar ataxia (HP:0002073)1.64772738
169Impaired vibration sensation in the lower limbs (HP:0002166)1.64267785
170Hypertensive crisis (HP:0100735)1.63701575
171Spinal canal stenosis (HP:0003416)1.58136695
172Severe muscular hypotonia (HP:0006829)1.57954678
173Congenital stationary night blindness (HP:0007642)1.57405470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.85677559
2EIF2AK13.56248705
3ICK3.40608885
4EPHA43.22997112
5TLK13.14154616
6VRK22.95119435
7WEE12.92297387
8BCKDK2.90535539
9DDR22.80632445
10MAPK152.77087238
11PIM22.44162324
12PAK62.30694274
13TESK22.24456136
14DAPK12.22942416
15MAP3K62.13192399
16DAPK22.13107120
17SRPK12.08065882
18PINK12.05429863
19NEK12.02323266
20UHMK12.01442660
21CAMKK11.95455298
22CDK71.87369969
23STK161.81300956
24NME21.80661439
25DYRK31.66308034
26LATS21.64907238
27MATK1.64905562
28YES11.64206381
29EIF2AK31.63486598
30PRKD31.61847351
31AKT31.61471812
32MAP2K71.61243948
33MARK11.58170257
34FGR1.54267926
35GRK51.54069355
36CDC71.53954506
37* PLK11.45193018
38CHEK21.39897023
39SIK21.37428622
40NTRK31.32845634
41NME11.31241977
42TYRO31.29569389
43VRK11.29394035
44EPHA21.24830334
45PLK41.24119397
46BRSK11.18356350
47NTRK11.17902663
48ABL21.17096517
49DYRK21.17095401
50PRKD21.16078505
51TESK11.15272176
52LIMK11.13051604
53NEK21.11767029
54NTRK21.11255107
55CAMKK21.11218010
56TAOK21.09880136
57CSNK1G31.06322152
58DYRK1B1.05050183
59MKNK21.03207854
60TTK1.00712149
61* AURKA0.99820653
62ATR0.99449411
63CAMK10.99340101
64RPS6KL10.98723023
65RPS6KC10.98723023
66BRAF0.95514735
67MAP4K10.93873593
68MAPK130.92674842
69BMX0.91050919
70CSNK1G20.90563297
71AURKB0.90421303
72PBK0.89688651
73PRKCG0.89549854
74PRPF4B0.87600617
75ACVR1B0.87369355
76FES0.86638729
77PIM10.85573353
78CDK50.84295746
79RPS6KA60.83938264
80TSSK60.82666166
81CSNK2A10.82498465
82CCNB10.81893599
83RPS6KB20.80648188
84BRSK20.76936597
85STK38L0.76422999
86MKNK10.76139366
87PAK40.75968479
88PAK10.75242906
89CDC42BPA0.75049656
90MAPK120.74019960
91PKN10.73554207
92CSNK2A20.72311389
93MARK20.72020621
94CSK0.70964892
95CSNK1A1L0.70231035
96PRKCI0.66930583
97ZAK0.66524913
98PHKG20.66506152
99PHKG10.66506152
100SMG10.65196173
101PLK20.64151824
102PLK30.63508540
103GRK60.63385226
104CDK20.63372547
105SCYL20.63267463
106CAMK40.62719143
107MAP3K80.60668896
108* MAP3K110.60583143
109PRKCH0.59490691
110MAPKAPK30.59342772
111CHEK10.58429060
112ARAF0.57125454
113CAMK2A0.56968539
114CDK80.54978331
115LRRK20.54423128
116MAPKAPK50.53969229
117DAPK30.53009200
118CDK140.52832639
119CAMK2B0.52253528
120STK110.51686692
121CDK11A0.50357412
122CDK180.49851434
123IRAK30.49749212
124CDK150.48269808
125TNK20.48210528
126RPS6KA10.47952132
127MAP2K40.46816620
128CDK190.46793991
129PASK0.46463675
130RPS6KA40.46244843
131TRIB30.44876400
132ERN10.44711160
133CSNK1G10.44468617
134TBK10.43185148
135RIPK40.42738745
136ATM0.42200493
137CAMK2G0.41971271
138ADRBK20.41656217
139KDR0.41225498
140PRKCQ0.40871234
141MAP4K20.40526185
142MAP2K20.40162385
143RPS6KA20.38537491
144SYK0.38124116
145PDK10.38003033
146WNK40.37709562
147CDK10.37447906
148MAPK110.37124916
149MAP2K60.37090319
150MINK10.35902687
151PDGFRA0.35058541
152GSK3A0.34559396
153ILK0.34421026
154RPS6KA50.33756205
155CASK0.32904939

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.69177015
2DNA replication_Homo sapiens_hsa030304.50790075
3Ribosome_Homo sapiens_hsa030104.08211754
4Proteasome_Homo sapiens_hsa030504.01427926
5Base excision repair_Homo sapiens_hsa034103.63951485
6Spliceosome_Homo sapiens_hsa030403.28489147
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27693479
8RNA polymerase_Homo sapiens_hsa030203.07936867
9Nucleotide excision repair_Homo sapiens_hsa034202.80983465
10RNA transport_Homo sapiens_hsa030132.74925565
11Homologous recombination_Homo sapiens_hsa034402.72798463
12Nicotine addiction_Homo sapiens_hsa050332.63963664
13Oxidative phosphorylation_Homo sapiens_hsa001902.36557371
14Parkinsons disease_Homo sapiens_hsa050122.25075339
15Fanconi anemia pathway_Homo sapiens_hsa034602.10771859
16Pyrimidine metabolism_Homo sapiens_hsa002402.06360915
17Huntingtons disease_Homo sapiens_hsa050161.93249605
18Cell cycle_Homo sapiens_hsa041101.92356033
19Morphine addiction_Homo sapiens_hsa050321.78880545
20GABAergic synapse_Homo sapiens_hsa047271.70090729
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69605508
22mRNA surveillance pathway_Homo sapiens_hsa030151.65440806
23Amphetamine addiction_Homo sapiens_hsa050311.54197635
24Circadian entrainment_Homo sapiens_hsa047131.52362511
25One carbon pool by folate_Homo sapiens_hsa006701.52208098
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51635566
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47617528
28Basal transcription factors_Homo sapiens_hsa030221.46162587
29p53 signaling pathway_Homo sapiens_hsa041151.39420167
30Insulin secretion_Homo sapiens_hsa049111.35602489
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.35587856
32Sulfur relay system_Homo sapiens_hsa041221.34745533
33Vitamin B6 metabolism_Homo sapiens_hsa007501.33264456
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32721824
35Alzheimers disease_Homo sapiens_hsa050101.30970478
36Fatty acid elongation_Homo sapiens_hsa000621.29889594
37Dopaminergic synapse_Homo sapiens_hsa047281.29455231
38RNA degradation_Homo sapiens_hsa030181.25267531
39Glutamatergic synapse_Homo sapiens_hsa047241.19692897
40Cocaine addiction_Homo sapiens_hsa050301.17847133
41Oocyte meiosis_Homo sapiens_hsa041141.15924587
42Cardiac muscle contraction_Homo sapiens_hsa042601.08297253
43Fatty acid biosynthesis_Homo sapiens_hsa000611.07904769
44Long-term potentiation_Homo sapiens_hsa047201.07835293
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06503504
46Biosynthesis of amino acids_Homo sapiens_hsa012301.06400677
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06179955
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03619174
49Purine metabolism_Homo sapiens_hsa002301.03313970
50Salivary secretion_Homo sapiens_hsa049701.03232629
51Olfactory transduction_Homo sapiens_hsa047401.02936159
52Hedgehog signaling pathway_Homo sapiens_hsa043401.01120489
53Folate biosynthesis_Homo sapiens_hsa007900.98231813
54Cholinergic synapse_Homo sapiens_hsa047250.96755068
55Epstein-Barr virus infection_Homo sapiens_hsa051690.93037499
56Gastric acid secretion_Homo sapiens_hsa049710.93012215
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92020655
58Hippo signaling pathway_Homo sapiens_hsa043900.91392911
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90726755
60Non-homologous end-joining_Homo sapiens_hsa034500.88178457
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87746594
62Protein export_Homo sapiens_hsa030600.85945855
63Calcium signaling pathway_Homo sapiens_hsa040200.84445306
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82538834
65Oxytocin signaling pathway_Homo sapiens_hsa049210.79487712
66Fructose and mannose metabolism_Homo sapiens_hsa000510.79178738
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76396103
68Arginine and proline metabolism_Homo sapiens_hsa003300.75204786
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74721673
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70073058
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68793684
72Basal cell carcinoma_Homo sapiens_hsa052170.67390233
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66776461
74Bladder cancer_Homo sapiens_hsa052190.65364630
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61158727
76Systemic lupus erythematosus_Homo sapiens_hsa053220.59981914
77Endocytosis_Homo sapiens_hsa041440.59385349
78Thyroid cancer_Homo sapiens_hsa052160.59199992
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58658500
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58649663
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.57292829
82Glutathione metabolism_Homo sapiens_hsa004800.56207512
83Shigellosis_Homo sapiens_hsa051310.55437779
84Peroxisome_Homo sapiens_hsa041460.54551610
85Wnt signaling pathway_Homo sapiens_hsa043100.54258231
86Notch signaling pathway_Homo sapiens_hsa043300.52300232
87Taste transduction_Homo sapiens_hsa047420.50292346
88TGF-beta signaling pathway_Homo sapiens_hsa043500.49789806
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49158930
90Viral carcinogenesis_Homo sapiens_hsa052030.48383309
91cAMP signaling pathway_Homo sapiens_hsa040240.47201005
92Galactose metabolism_Homo sapiens_hsa000520.47108958
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45331376
94Circadian rhythm_Homo sapiens_hsa047100.44585065
95mTOR signaling pathway_Homo sapiens_hsa041500.44433981
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43644477
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42266993
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.42206385
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40408096
100Alcoholism_Homo sapiens_hsa050340.39733863
101Butanoate metabolism_Homo sapiens_hsa006500.37878609
102Metabolic pathways_Homo sapiens_hsa011000.36464891
103Regulation of autophagy_Homo sapiens_hsa041400.36298779
104Synaptic vesicle cycle_Homo sapiens_hsa047210.36117147
105Salmonella infection_Homo sapiens_hsa051320.35519881
106Pentose phosphate pathway_Homo sapiens_hsa000300.35224682
107Gap junction_Homo sapiens_hsa045400.33839754
108Vibrio cholerae infection_Homo sapiens_hsa051100.33640907
109Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33372368
110Pyruvate metabolism_Homo sapiens_hsa006200.33222311
111Phenylalanine metabolism_Homo sapiens_hsa003600.32925167
112Carbon metabolism_Homo sapiens_hsa012000.32571015
113Tight junction_Homo sapiens_hsa045300.30751752
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29801798
115Colorectal cancer_Homo sapiens_hsa052100.29493165
116HTLV-I infection_Homo sapiens_hsa051660.29107028
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28836181
118Serotonergic synapse_Homo sapiens_hsa047260.28441895
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28011896
120Legionellosis_Homo sapiens_hsa051340.27786648
121N-Glycan biosynthesis_Homo sapiens_hsa005100.27144349
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.26095325
123Collecting duct acid secretion_Homo sapiens_hsa049660.26084407
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25521736
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24807672
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24695798
127Prion diseases_Homo sapiens_hsa050200.24441968
128Herpes simplex infection_Homo sapiens_hsa051680.24316467
129Long-term depression_Homo sapiens_hsa047300.22472586
130Phototransduction_Homo sapiens_hsa047440.22106265
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21869216
132Arachidonic acid metabolism_Homo sapiens_hsa005900.21354902
133Adherens junction_Homo sapiens_hsa045200.19249744
134HIF-1 signaling pathway_Homo sapiens_hsa040660.18494185
135MicroRNAs in cancer_Homo sapiens_hsa052060.15962983
136Lysosome_Homo sapiens_hsa041420.15728887
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.15361863
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.14855562
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13725157
140Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13482839
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.13111191
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12430459
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12315563
144VEGF signaling pathway_Homo sapiens_hsa043700.11260643
145Melanoma_Homo sapiens_hsa052180.09895140
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.09885063
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08758297
148Primary immunodeficiency_Homo sapiens_hsa053400.07526794
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06163794
150Pathways in cancer_Homo sapiens_hsa052000.03340125

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