PINK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muscle activity (GO:0014850)3.88557469
2actin-mediated cell contraction (GO:0070252)3.71590674
3positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.70913758
4cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.69051695
5carnitine shuttle (GO:0006853)3.63440946
6lysine catabolic process (GO:0006554)3.63141716
7lysine metabolic process (GO:0006553)3.63141716
8regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.56824123
9tricarboxylic acid cycle (GO:0006099)3.54888329
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54732489
112-oxoglutarate metabolic process (GO:0006103)3.53514483
12synaptic vesicle maturation (GO:0016188)3.53417238
13fatty acid transmembrane transport (GO:1902001)3.44404486
14aspartate family amino acid catabolic process (GO:0009068)3.44298666
15negative regulation of potassium ion transmembrane transport (GO:1901380)3.37853027
16plasma membrane repair (GO:0001778)3.34639899
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.33884290
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31537810
19regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.30019444
20* regulation of synaptic vesicle transport (GO:1902803)3.29203655
21cell communication by electrical coupling (GO:0010644)3.26638485
22sarcoplasmic reticulum calcium ion transport (GO:0070296)3.24394953
23regulation of synapse structural plasticity (GO:0051823)3.20243105
24succinate metabolic process (GO:0006105)3.19589749
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.18753408
26locomotory exploration behavior (GO:0035641)3.16179290
27sodium ion export (GO:0071436)3.16164667
28cell communication involved in cardiac conduction (GO:0086065)3.12299578
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.11575512
30dicarboxylic acid biosynthetic process (GO:0043650)3.09288528
31potassium ion import (GO:0010107)3.09111702
32cardiac muscle contraction (GO:0060048)3.08243467
33sarcomere organization (GO:0045214)3.06817269
34regulation of relaxation of muscle (GO:1901077)3.06147162
35NADH metabolic process (GO:0006734)3.05127145
36cerebellar granule cell differentiation (GO:0021707)3.02141471
37skeletal muscle contraction (GO:0003009)2.99887420
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.99245993
39cGMP-mediated signaling (GO:0019934)2.99103838
40cellular potassium ion homeostasis (GO:0030007)2.98715001
41cardiac muscle hypertrophy (GO:0003300)2.98645560
42actin filament-based movement (GO:0030048)2.97781364
43neuronal action potential propagation (GO:0019227)2.97226624
44positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96290204
45carnitine transmembrane transport (GO:1902603)2.96196804
46activation of protein kinase A activity (GO:0034199)2.96083780
47positive regulation of synapse maturation (GO:0090129)2.95859725
48regulation of membrane repolarization (GO:0060306)2.95334726
49cellular ketone body metabolic process (GO:0046950)2.94468846
50carnitine transport (GO:0015879)2.93207074
51amino-acid betaine transport (GO:0015838)2.93207074
52regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.92797352
53alpha-linolenic acid metabolic process (GO:0036109)2.91085333
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.90058181
55neuronal ion channel clustering (GO:0045161)2.88931726
56muscle filament sliding (GO:0030049)2.88183773
57actin-myosin filament sliding (GO:0033275)2.88183773
58short-chain fatty acid metabolic process (GO:0046459)2.87835189
59L-amino acid import (GO:0043092)2.87709482
60dicarboxylic acid catabolic process (GO:0043649)2.87558079
61striated muscle hypertrophy (GO:0014897)2.86316209
62response to mercury ion (GO:0046689)2.86060980
63regulation of neuronal synaptic plasticity (GO:0048168)2.84803396
64fatty acid beta-oxidation (GO:0006635)2.84207639
65regulation of skeletal muscle contraction (GO:0014819)2.84075511
66muscle cell cellular homeostasis (GO:0046716)2.83981049
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.83053734
68L-phenylalanine catabolic process (GO:0006559)2.83053734
69creatine metabolic process (GO:0006600)2.80515250
70L-phenylalanine metabolic process (GO:0006558)2.80263158
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80263158
72skeletal muscle fiber development (GO:0048741)2.79728555
73glutamate secretion (GO:0014047)2.79394523
74regulation of cell communication by electrical coupling (GO:0010649)2.77795976
75potassium ion homeostasis (GO:0055075)2.77031198
76glutamate metabolic process (GO:0006536)2.76427096
77cardiac myofibril assembly (GO:0055003)2.75756480
78muscle contraction (GO:0006936)2.75487940
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.75200850
80regulation of fatty acid oxidation (GO:0046320)2.73853902
81oxaloacetate metabolic process (GO:0006107)2.73670817
82relaxation of smooth muscle (GO:0044557)2.73629331
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72871054
84cellular response to epinephrine stimulus (GO:0071872)2.72780220
85regulation of calcium ion transmembrane transporter activity (GO:1901019)2.72669750
86regulation of calcium ion transmembrane transport (GO:1903169)2.72669750
87regulation of acyl-CoA biosynthetic process (GO:0050812)2.72447208
88vocalization behavior (GO:0071625)2.72033534
89regulation of voltage-gated calcium channel activity (GO:1901385)2.70756801
90fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.70536348
91striated muscle contraction (GO:0006941)2.69229359
92axon ensheathment in central nervous system (GO:0032291)2.68736801
93central nervous system myelination (GO:0022010)2.68736801
94relaxation of muscle (GO:0090075)2.68238109
95synaptic vesicle docking involved in exocytosis (GO:0016081)2.67444598
96glycogen catabolic process (GO:0005980)2.66941173
97neurotransmitter secretion (GO:0007269)2.66346467
98regulation of ARF protein signal transduction (GO:0032012)2.65632641
99myofibril assembly (GO:0030239)2.65493524
100tricarboxylic acid metabolic process (GO:0072350)2.63937998
101positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.63839048
102cardiac muscle adaptation (GO:0014887)2.63407335
103cardiac muscle hypertrophy in response to stress (GO:0014898)2.63407335
104muscle hypertrophy in response to stress (GO:0003299)2.63407335
105amino acid import (GO:0043090)2.63101004
106detection of calcium ion (GO:0005513)2.62720506
107regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.61177845
108ADP metabolic process (GO:0046031)2.61023570
109synaptic vesicle exocytosis (GO:0016079)2.60705678
110fatty acid catabolic process (GO:0009062)2.60589592
111ventricular cardiac muscle cell action potential (GO:0086005)2.60015391
112acetyl-CoA metabolic process (GO:0006084)2.59859762
113neuromuscular synaptic transmission (GO:0007274)2.59132678
114neuromuscular process controlling balance (GO:0050885)2.58234397
115gamma-aminobutyric acid transport (GO:0015812)2.57840490
116muscle system process (GO:0003012)2.57500876
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.57406337
118regulation of synaptic vesicle exocytosis (GO:2000300)2.56323536
119regulation of synapse maturation (GO:0090128)2.55487120
120muscle hypertrophy (GO:0014896)2.55184623
121regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54680299
122fatty acid oxidation (GO:0019395)2.54255216
123exploration behavior (GO:0035640)2.53703861
124regulation of actin filament-based movement (GO:1903115)2.53280626
125glyoxylate metabolic process (GO:0046487)2.52395758
126glucan catabolic process (GO:0009251)2.52250854
127lipid oxidation (GO:0034440)2.51557609
128nucleoside diphosphate biosynthetic process (GO:0009133)2.51117708
129ketone body metabolic process (GO:1902224)2.50955695
130response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.50865173
131quaternary ammonium group transport (GO:0015697)2.49951713
132regulation of sequestering of triglyceride (GO:0010889)2.49271263
133glycine transport (GO:0015816)2.47503123
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.47426934
135monocarboxylic acid catabolic process (GO:0072329)2.47393310
136regulation of cofactor metabolic process (GO:0051193)2.46179453
137regulation of coenzyme metabolic process (GO:0051196)2.46179453
138triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.45617600
139kynurenine metabolic process (GO:0070189)2.44492186
140cellular sodium ion homeostasis (GO:0006883)2.43857882
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.43673515
142positive regulation of fatty acid oxidation (GO:0046321)2.43145174
143membrane depolarization during action potential (GO:0086010)2.43111185
144regulation of glutamate receptor signaling pathway (GO:1900449)2.42654910
145cellular response to catecholamine stimulus (GO:0071870)2.42531628
146cellular response to monoamine stimulus (GO:0071868)2.42531628
147positive regulation of fatty acid beta-oxidation (GO:0032000)2.41936586
148response to epinephrine (GO:0071871)2.40903418
149regulation of synaptic plasticity (GO:0048167)2.39212468
150postsynaptic membrane organization (GO:0001941)2.38596796
151cellular response to cadmium ion (GO:0071276)2.37916067
152actomyosin structure organization (GO:0031032)2.36172332
153myotube cell development (GO:0014904)2.35301580
154barbed-end actin filament capping (GO:0051016)2.35298809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.80978822
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60164481
3EZH2_22144423_ChIP-Seq_EOC_Human3.54238014
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.69219202
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.60706302
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.44241694
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29798674
8* LXR_22158963_ChIP-Seq_LIVER_Mouse2.26581849
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19072655
10DROSHA_22980978_ChIP-Seq_HELA_Human2.17701636
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08190553
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.07133886
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02409144
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95488922
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94635976
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.94133862
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91860789
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90442705
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86805402
20RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86805402
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.69227501
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67808569
23* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67487355
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.67311787
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63686207
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63154087
27REST_21632747_ChIP-Seq_MESCs_Mouse1.58757323
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57641631
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.56026458
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55504317
31ZNF263_19887448_ChIP-Seq_K562_Human1.54469797
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53339545
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.53190806
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52933220
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.50000339
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.47291725
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42664597
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39469281
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.39214114
40* EP300_21415370_ChIP-Seq_HL-1_Mouse1.38109325
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34336366
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.31540129
43LXR_22292898_ChIP-Seq_THP-1_Human1.31253093
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30585666
45* TBX20_22080862_ChIP-Seq_HEART_Mouse1.30461076
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.30461076
47* KDM2B_26808549_Chip-Seq_K562_Human1.27327867
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.24172415
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23149234
50* CTCF_27219007_Chip-Seq_Bcells_Human1.23011435
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22075269
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17540709
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14525138
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.14325625
55AR_21572438_ChIP-Seq_LNCaP_Human1.13051413
56FOXA2_19822575_ChIP-Seq_HepG2_Human1.12668646
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12644356
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11524991
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11125152
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07320414
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07161525
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05488113
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04239773
64* RACK7_27058665_Chip-Seq_MCF-7_Human1.03074198
65GBX2_23144817_ChIP-Seq_PC3_Human1.02859257
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01659732
67ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01570244
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.01243675
69* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01115281
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.01052413
71ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00760360
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00422037
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98738024
74TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98586458
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97685782
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97333561
77SMC4_20622854_ChIP-Seq_HELA_Human0.97083396
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97080751
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96845339
80IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95502193
81* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95430734
82MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95316770
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95042905
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.94384503
85TP53_23651856_ChIP-Seq_MEFs_Mouse0.94068555
86CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93978766
87KLF4_19829295_ChIP-Seq_ESCs_Human0.93023746
88TET1_21451524_ChIP-Seq_MESCs_Mouse0.92780061
89NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92380843
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.92379770
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91284544
92SOX2_21211035_ChIP-Seq_LN229_Gbm0.91007260
93GATA1_19941826_ChIP-Seq_K562_Human0.90837239
94* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89829689
95CLOCK_20551151_ChIP-Seq_293T_Human0.89769201
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89507667
97ZNF274_21170338_ChIP-Seq_K562_Hela0.89217882
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.88949195
99* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88042405
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88038345
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.86601529
102P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86254217
103* KDM2B_26808549_Chip-Seq_DND41_Human0.86188658
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.83656739
105AR_19668381_ChIP-Seq_PC3_Human0.83415890
106* CREB1_26743006_Chip-Seq_LNCaP_Human0.83248386
107* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83127011
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80649056
109P68_20966046_ChIP-Seq_HELA_Human0.80513055
110TP63_22573176_ChIP-Seq_HFKS_Human0.78261029
111SMAD3_21741376_ChIP-Seq_HESCs_Human0.77650654
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76776942
113SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76682710
114GATA1_22025678_ChIP-Seq_K562_Human0.75842267
115SMAD4_21799915_ChIP-Seq_A2780_Human0.75224195
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.75220611
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.75204474
118BCAT_22108803_ChIP-Seq_LS180_Human0.72934427
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.72640576
120MYC_27129775_Chip-Seq_CORNEA_Mouse0.72590444
121FOXH1_21741376_ChIP-Seq_ESCs_Human0.72048059
122RXR_22108803_ChIP-Seq_LS180_Human0.72035513
123SA1_27219007_Chip-Seq_Bcells_Human0.71730502
124OCT4_19829295_ChIP-Seq_ESCs_Human0.71642328
125CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.70994785
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.70874800
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70694186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.07385854
2MP0003646_muscle_fatigue3.75424716
3MP0004859_abnormal_synaptic_plasticity3.60909936
4MP0000751_myopathy3.60244553
5MP0002139_abnormal_hepatobiliary_system2.79903158
6MP0004130_abnormal_muscle_cell2.73946310
7MP0002822_catalepsy2.65318118
8MP0005360_urolithiasis2.63700579
9MP0000749_muscle_degeneration2.54209714
10MP0004036_abnormal_muscle_relaxation2.51410944
11MP0004145_abnormal_muscle_electrophysio2.45757516
12MP0004215_abnormal_myocardial_fiber2.40791626
13MP0005085_abnormal_gallbladder_physiolo2.33227686
14MP0004084_abnormal_cardiac_muscle2.30173489
15* MP0003635_abnormal_synaptic_transmissio2.11754866
16MP0004270_analgesia2.09056534
17MP0005365_abnormal_bile_salt2.06936346
18MP0000747_muscle_weakness1.98791358
19MP0005330_cardiomyopathy1.95522579
20MP0005451_abnormal_body_composition1.90675509
21MP0002909_abnormal_adrenal_gland1.89293815
22MP0004087_abnormal_muscle_fiber1.86044373
23MP0008875_abnormal_xenobiotic_pharmacok1.74569810
24MP0005620_abnormal_muscle_contractility1.74341051
25MP0009745_abnormal_behavioral_response1.72544648
26MP0003329_amyloid_beta_deposits1.70747755
27MP0002269_muscular_atrophy1.69720300
28MP0003880_abnormal_central_pattern1.68072821
29MP0002064_seizures1.64001971
30MP0010329_abnormal_lipoprotein_level1.62324044
31MP0004043_abnormal_pH_regulation1.60219016
32MP0002063_abnormal_learning/memory/cond1.57242559
33MP0008004_abnormal_stomach_pH1.55891275
34MP0002106_abnormal_muscle_physiology1.55024343
35MP0003137_abnormal_impulse_conducting1.52281545
36MP0009046_muscle_twitch1.52247200
37MP0009780_abnormal_chondrocyte_physiolo1.52154750
38MP0002972_abnormal_cardiac_muscle1.50797538
39MP0003705_abnormal_hypodermis_morpholog1.50536868
40MP0005083_abnormal_biliary_tract1.48448670
41MP0005332_abnormal_amino_acid1.47682105
42MP0004484_altered_response_of1.45482281
43MP0000920_abnormal_myelination1.41957773
44MP0000759_abnormal_skeletal_muscle1.41509409
45MP0000013_abnormal_adipose_tissue1.38869075
46MP0008569_lethality_at_weaning1.38801564
47MP0009840_abnormal_foam_cell1.37688119
48MP0008961_abnormal_basal_metabolism1.36261261
49MP0005535_abnormal_body_temperature1.35055657
50MP0010368_abnormal_lymphatic_system1.33593935
51MP0004085_abnormal_heartbeat1.32536538
52* MP0006036_abnormal_mitochondrial_physio1.32522851
53MP0003195_calcinosis1.31662596
54MP0003252_abnormal_bile_duct1.31633425
55MP0005666_abnormal_adipose_tissue1.30834909
56* MP0002272_abnormal_nervous_system1.29329172
57MP0005369_muscle_phenotype1.28407004
58MP0002118_abnormal_lipid_homeostasis1.28143280
59MP0004233_abnormal_muscle_weight1.26629633
60MP0003045_fibrosis1.26177380
61MP0004858_abnormal_nervous_system1.24484179
62MP0008775_abnormal_heart_ventricle1.23928383
63MP0001968_abnormal_touch/_nociception1.22687343
64MP0002108_abnormal_muscle_morphology1.21714788
65MP0005584_abnormal_enzyme/coenzyme_acti1.21203047
66MP0000750_abnormal_muscle_regeneration1.18724321
67MP0005385_cardiovascular_system_phenoty1.17769210
68MP0001544_abnormal_cardiovascular_syste1.17769210
69MP0002572_abnormal_emotion/affect_behav1.16241406
70MP0001486_abnormal_startle_reflex1.15874819
71MP0005166_decreased_susceptibility_to1.14614716
72MP0003690_abnormal_glial_cell1.13952756
73MP0002734_abnormal_mechanical_nocicepti1.12278946
74MP0005670_abnormal_white_adipose1.12196305
75MP0001501_abnormal_sleep_pattern1.12057987
76MP0000733_abnormal_muscle_development1.11361413
77MP0003191_abnormal_cellular_cholesterol1.10568168
78MP0005167_abnormal_blood-brain_barrier1.10452409
79MP0006138_congestive_heart_failure1.10263305
80MP0003075_altered_response_to1.08947387
81MP0001440_abnormal_grooming_behavior1.05260396
82MP0003806_abnormal_nucleotide_metabolis1.05225326
83MP0005409_darkened_coat_color1.03838120
84* MP0003633_abnormal_nervous_system1.03051720
85MP0001958_emphysema1.02800372
86MP0002971_abnormal_brown_adipose1.01862984
87MP0000604_amyloidosis1.01721088
88MP0005375_adipose_tissue_phenotype1.01332627
89MP0002332_abnormal_exercise_endurance1.01308243
90MP0010630_abnormal_cardiac_muscle1.01096655
91MP0003634_abnormal_glial_cell1.00904336
92MP0005423_abnormal_somatic_nervous1.00070324
93MP0008874_decreased_physiological_sensi0.98861347
94MP0004924_abnormal_behavior0.96439212
95MP0005386_behavior/neurological_phenoty0.96439212
96MP0002078_abnormal_glucose_homeostasis0.95351212
97MP0004510_myositis0.93877516
98MP0001502_abnormal_circadian_rhythm0.93769124
99MP0001984_abnormal_olfaction0.93427595
100MP0002127_abnormal_cardiovascular_syste0.92530784
101MP0004885_abnormal_endolymph0.92368287
102MP0002067_abnormal_sensory_capabilities0.92028131
103* MP0003631_nervous_system_phenotype0.91968034
104MP0001849_ear_inflammation0.91879256
105MP0001666_abnormal_nutrient_absorption0.91121415
106MP0005319_abnormal_enzyme/_coenzyme0.90752907
107MP0003879_abnormal_hair_cell0.90669149
108MP0000230_abnormal_systemic_arterial0.90225568
109MP0000343_altered_response_to0.89556713
110MP0003828_pulmonary_edema0.88447319
111MP0002733_abnormal_thermal_nociception0.88327183
112MP0004185_abnormal_adipocyte_glucose0.86704114
113* MP0004811_abnormal_neuron_physiology0.86544537
114MP0001970_abnormal_pain_threshold0.84928675
115MP0003656_abnormal_erythrocyte_physiolo0.84913304
116MP0006035_abnormal_mitochondrial_morpho0.84708206
117MP0001765_abnormal_ion_homeostasis0.84490137
118MP0002736_abnormal_nociception_after0.83788380
119MP0005623_abnormal_meninges_morphology0.81961004
120MP0002735_abnormal_chemical_nociception0.81022832
121MP0008260_abnormal_autophagy0.78600887
122* MP0002066_abnormal_motor_capabilities/c0.78223269
123MP0000003_abnormal_adipose_tissue0.77332231
124MP0003279_aneurysm0.76065991
125MP0003632_abnormal_nervous_system0.75847615
126MP0001664_abnormal_digestion0.73411441
127MP0000955_abnormal_spinal_cord0.68316626
128MP0002882_abnormal_neuron_morphology0.68286449

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.35618072
2Exercise-induced muscle cramps (HP:0003710)4.43340596
3Myoglobinuria (HP:0002913)4.26289984
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.25967779
5Sudden death (HP:0001699)4.25790315
6Calf muscle hypertrophy (HP:0008981)4.06883531
7Muscle hypertrophy of the lower extremities (HP:0008968)3.98986429
8Bundle branch block (HP:0011710)3.68904876
9Hyporeflexia of lower limbs (HP:0002600)3.54075004
10Myokymia (HP:0002411)3.48339029
11Muscle fiber splitting (HP:0003555)3.44387562
12Difficulty running (HP:0009046)3.36597643
13Scapular winging (HP:0003691)3.33452946
14Neck muscle weakness (HP:0000467)3.30853138
15Ketoacidosis (HP:0001993)3.26255504
16Frequent falls (HP:0002359)3.26011859
17Ketosis (HP:0001946)3.19381183
18Focal motor seizures (HP:0011153)3.14507334
19Ventricular fibrillation (HP:0001663)3.12717147
20Abnormality of the calf musculature (HP:0001430)3.11121661
21Myotonia (HP:0002486)3.04928897
22Foot dorsiflexor weakness (HP:0009027)3.04606317
23Spinal rigidity (HP:0003306)3.00273254
24Gout (HP:0001997)2.92763785
25EMG: myopathic abnormalities (HP:0003458)2.91507202
26Abnormality of the foot musculature (HP:0001436)2.91052657
27Heart block (HP:0012722)2.90795510
28Neurofibrillary tangles (HP:0002185)2.89202028
29Muscle fiber inclusion bodies (HP:0100299)2.85651472
30Distal lower limb muscle weakness (HP:0009053)2.85171541
31Muscle stiffness (HP:0003552)2.83019820
32Asymmetric septal hypertrophy (HP:0001670)2.80450643
33Rimmed vacuoles (HP:0003805)2.80385524
34Atonic seizures (HP:0010819)2.79432978
35Visual hallucinations (HP:0002367)2.79341044
36Atrioventricular block (HP:0001678)2.75087285
37Ventricular tachycardia (HP:0004756)2.74488571
38Atrial fibrillation (HP:0005110)2.70634152
39Rhabdomyolysis (HP:0003201)2.68217092
40Abnormal atrioventricular conduction (HP:0005150)2.67575346
41Syncope (HP:0001279)2.67560825
42Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.67118514
43Round ear (HP:0100830)2.66778006
44Bulbar palsy (HP:0001283)2.66698103
45Hyperglycinuria (HP:0003108)2.63193960
46Hyperammonemia (HP:0001987)2.61851788
47Prolonged QT interval (HP:0001657)2.59198915
48Primary atrial arrhythmia (HP:0001692)2.56830588
49Obstructive sleep apnea (HP:0002870)2.55707527
50Diplopia (HP:0000651)2.55374264
51Abnormality of binocular vision (HP:0011514)2.55374264
52Cerebral inclusion bodies (HP:0100314)2.54256216
53Type 1 muscle fiber predominance (HP:0003803)2.52737148
54Dysmetric saccades (HP:0000641)2.47296534
55Ventricular arrhythmia (HP:0004308)2.46838653
56Abnormality of serine family amino acid metabolism (HP:0010894)2.44744980
57Abnormality of glycine metabolism (HP:0010895)2.44744980
58Hypoglycemic coma (HP:0001325)2.44419611
59Abnormality of fatty-acid metabolism (HP:0004359)2.44402523
60Pheochromocytoma (HP:0002666)2.43241920
61Increased variability in muscle fiber diameter (HP:0003557)2.43181358
62Abnormality of the left ventricular outflow tract (HP:0011103)2.43030946
63Subaortic stenosis (HP:0001682)2.43030946
64Supraventricular tachycardia (HP:0004755)2.42656945
65Xanthomatosis (HP:0000991)2.42532250
66Distal lower limb amyotrophy (HP:0008944)2.42452560
67Lower limb amyotrophy (HP:0007210)2.42362245
68Palpitations (HP:0001962)2.41113016
69Abnormality of the shoulder girdle musculature (HP:0001435)2.40008006
70Increased connective tissue (HP:0009025)2.39894457
71Deep venous thrombosis (HP:0002625)2.39826295
72Supraventricular arrhythmia (HP:0005115)2.36798705
73Action tremor (HP:0002345)2.32114630
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.31661447
75Cholelithiasis (HP:0001081)2.30612959
76Focal seizures (HP:0007359)2.28852931
77Right ventricular cardiomyopathy (HP:0011663)2.26619920
78Nemaline bodies (HP:0003798)2.25253955
79Mildly elevated creatine phosphokinase (HP:0008180)2.22686831
80Hyperlipoproteinemia (HP:0010980)2.19491138
81Febrile seizures (HP:0002373)2.19356389
82Abnormality of skeletal muscle fiber size (HP:0012084)2.19269800
83Impaired social interactions (HP:0000735)2.16657278
84Abnormal social behavior (HP:0012433)2.16657278
85Abnormal EKG (HP:0003115)2.16050280
86Axonal loss (HP:0003447)2.15557336
87Difficulty climbing stairs (HP:0003551)2.15220381
88Hyperglycinemia (HP:0002154)2.15210306
89Hypoalphalipoproteinemia (HP:0003233)2.13547978
90Fetal akinesia sequence (HP:0001989)2.13116884
91Abnormal gallbladder morphology (HP:0012437)2.11462007
92Lipoatrophy (HP:0100578)2.11164035
93Abnormality of the Achilles tendon (HP:0005109)2.08239612
94Neuroendocrine neoplasm (HP:0100634)2.07508427
95Ankle clonus (HP:0011448)2.06160159
96Ulnar deviation of the wrist (HP:0003049)2.04518668
97Poor eye contact (HP:0000817)2.04198429
98Distal arthrogryposis (HP:0005684)2.01623211
99Generalized tonic-clonic seizures (HP:0002069)2.01217567
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00775410
101Dilated cardiomyopathy (HP:0001644)2.00534228
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99662068
103Dicarboxylic aciduria (HP:0003215)1.99662068
104Generalized muscle weakness (HP:0003324)1.97719973
105Hyperuricemia (HP:0002149)1.96019927
106Increased purine levels (HP:0004368)1.96019927
107Weak cry (HP:0001612)1.94907665
108Dysdiadochokinesis (HP:0002075)1.94483664
109Achilles tendon contracture (HP:0001771)1.92293479
110Impaired vibration sensation in the lower limbs (HP:0002166)1.91276753
111Muscular dystrophy (HP:0003560)1.90966393
112Supranuclear gaze palsy (HP:0000605)1.90216073
113Abnormality of the lower motor neuron (HP:0002366)1.90055325
114Areflexia of lower limbs (HP:0002522)1.89825379
115Myopathic facies (HP:0002058)1.89754595
116Nonprogressive disorder (HP:0003680)1.87304073
117Proximal amyotrophy (HP:0007126)1.87178534
118EMG: neuropathic changes (HP:0003445)1.86860834
119Rapidly progressive (HP:0003678)1.86589274
120Absence seizures (HP:0002121)1.86408873
121Dysmetria (HP:0001310)1.86298267
122Neonatal onset (HP:0003623)1.86149746
123Truncal ataxia (HP:0002078)1.85906376
124Metabolic acidosis (HP:0001942)1.85130564
125Abnormal gallbladder physiology (HP:0012438)1.83972714
126Cholecystitis (HP:0001082)1.83972714
127Steppage gait (HP:0003376)1.83089109
128Torticollis (HP:0000473)1.82785815
129Intrahepatic cholestasis (HP:0001406)1.81443079
130Status epilepticus (HP:0002133)1.81063799
131Abnormal eating behavior (HP:0100738)1.80342996
132Central scotoma (HP:0000603)1.78503233
133Gowers sign (HP:0003391)1.78486404
134* Anxiety (HP:0000739)1.77786008
135Limb-girdle muscle atrophy (HP:0003797)1.76115480
136Ragged-red muscle fibers (HP:0003200)1.75441498
137Abnormality of purine metabolism (HP:0004352)1.75174106
138Slender build (HP:0001533)1.74828556
139Malignant hyperthermia (HP:0002047)1.74625744
140Respiratory insufficiency due to muscle weakness (HP:0002747)1.72187748
141Aortic aneurysm (HP:0004942)1.71862590
142Spastic gait (HP:0002064)1.70580392
143Lower limb muscle weakness (HP:0007340)1.69475922
144* Rigidity (HP:0002063)1.69189132

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG23.06346175
2PHKG13.06346175
3TRIB32.88121654
4TTN2.73392579
5EPHA42.62448178
6OBSCN2.50338847
7LMTK22.49492936
8BCKDK2.47072395
9PDK42.36186089
10PDK32.36186089
11PRKD32.31389393
12MAP3K92.30023300
13NTRK32.07953595
14LATS22.02397871
15DAPK22.01394205
16KSR22.00172630
17MAP2K41.94335557
18PRPF4B1.76443071
19MAP3K41.73863580
20PKN21.69573067
21STK381.69360922
22PAK61.65322373
23NEK11.65107164
24CAMKK11.60761125
25RIPK11.55040751
26MARK31.50314957
27MAP3K71.47538918
28MINK11.45051083
29DMPK1.39888141
30PDK21.39663379
31NTRK11.31069197
32MOS1.16203567
33TAOK11.13291053
34WNK41.11666874
35PRKCH1.08126498
36MAP3K111.05703429
37PDPK11.03024012
38EEF2K1.02649402
39RET1.01362518
40MUSK1.00271262
41SGK30.99588127
42MAPK120.98928379
43SGK4940.98048659
44SGK2230.98048659
45MAP3K20.97737178
46MARK10.95927553
47PDK10.95779232
48NTRK20.95565589
49MYLK0.95266761
50MAP3K30.94466582
51PAK30.93068572
52PRKG20.92162282
53CDK50.91624957
54WNK10.91347563
55CAMK2B0.90555372
56CAMK10.88340243
57MAP2K70.88101537
58MAP3K10.86756220
59SIK10.85867360
60GRK50.83834999
61TYRO30.83780040
62PRKD10.81254652
63PRKAA10.76387996
64CAMKK20.76254538
65BRAF0.74072357
66STK110.73840135
67TIE10.73309136
68ARAF0.72340151
69SGK20.71857499
70CAMK40.71484070
71CAMK2G0.71116663
72MAP3K130.71049124
73PTK2B0.70878618
74CAMK1G0.70458125
75KSR10.69282034
76PKN10.69027354
77ROCK20.68685660
78RIPK40.68001279
79CAMK2D0.67248899
80PDGFRA0.66467729
81RPS6KA20.66308862
82CAMK2A0.65344152
83INSRR0.64834218
84PRKCG0.63146389
85PIK3CA0.63045326
86CDK140.60858204
87PRKAA20.60031670
88FGFR40.59335119
89UHMK10.59165161
90LIMK10.58740427
91ERN10.58182738
92NME10.57231275
93TESK10.56986963
94TAOK20.56953346
95OXSR10.56800350
96SGK10.56736793
97ICK0.56720865
98MAP2K30.55514595
99EPHB10.55302634
100DAPK30.54255804
101MAP2K10.54058898
102MAP2K60.53994761
103AKT20.53925359
104CCNB10.53295695
105DAPK10.53140883
106IRAK20.53138382
107LATS10.52555568
108FGFR20.51105674
109PRKACG0.50768266
110CDK190.50610846
111PIK3CG0.50506560
112ROCK10.48499333
113MAP3K120.47955907
114MAP3K50.47627389
115RPS6KA30.47510527
116SIK20.47447191
117JAK20.46156027
118MAPK100.45590124
119PTK60.45570453
120CDC42BPA0.45355508
121TNK20.44488812
122MARK20.43512958
123MAPKAPK30.43064058
124PRKD20.42909276
125CDK150.42815072
126CAMK1D0.42611849
127PRKCZ0.41955843
128MAP3K60.41534044
129PRKG10.41359479
130RPS6KB10.40612420
131RAF10.39982970
132MAPK40.39842181

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.46915461
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.08114629
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.79849506
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.60456279
5Propanoate metabolism_Homo sapiens_hsa006402.33477211
6Fatty acid degradation_Homo sapiens_hsa000712.22411917
7Arginine biosynthesis_Homo sapiens_hsa002202.12781005
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00083661
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.94411542
10Butanoate metabolism_Homo sapiens_hsa006501.90607764
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.80331556
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80277727
13Fatty acid metabolism_Homo sapiens_hsa012121.77877230
14Cardiac muscle contraction_Homo sapiens_hsa042601.63840915
15PPAR signaling pathway_Homo sapiens_hsa033201.48246409
16Carbon metabolism_Homo sapiens_hsa012001.45621024
17Pyruvate metabolism_Homo sapiens_hsa006201.44509841
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42131409
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40576996
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40422374
21Bile secretion_Homo sapiens_hsa049761.39393167
22Synaptic vesicle cycle_Homo sapiens_hsa047211.34930078
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32915145
24Tryptophan metabolism_Homo sapiens_hsa003801.32366293
25Dilated cardiomyopathy_Homo sapiens_hsa054141.29144154
26Olfactory transduction_Homo sapiens_hsa047401.26697574
27GABAergic synapse_Homo sapiens_hsa047271.24662292
28Gastric acid secretion_Homo sapiens_hsa049711.19506190
29Circadian entrainment_Homo sapiens_hsa047131.18321353
30Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15097479
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14283103
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12342351
33Insulin secretion_Homo sapiens_hsa049111.11552621
34beta-Alanine metabolism_Homo sapiens_hsa004101.08238008
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.04548254
36Salivary secretion_Homo sapiens_hsa049701.04303815
37Long-term potentiation_Homo sapiens_hsa047201.04112817
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01796430
39Starch and sucrose metabolism_Homo sapiens_hsa005001.00604003
40Nicotine addiction_Homo sapiens_hsa050330.98707537
41Glutamatergic synapse_Homo sapiens_hsa047240.98677434
42Peroxisome_Homo sapiens_hsa041460.98273647
43Prion diseases_Homo sapiens_hsa050200.97372372
44Glioma_Homo sapiens_hsa052140.96803084
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.95827135
46Fatty acid biosynthesis_Homo sapiens_hsa000610.95743731
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94549195
48Biosynthesis of amino acids_Homo sapiens_hsa012300.94263804
49Morphine addiction_Homo sapiens_hsa050320.93853728
50Glucagon signaling pathway_Homo sapiens_hsa049220.93464598
51Oxytocin signaling pathway_Homo sapiens_hsa049210.93218728
52Renin secretion_Homo sapiens_hsa049240.93072343
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92522494
54Amphetamine addiction_Homo sapiens_hsa050310.90986120
55Calcium signaling pathway_Homo sapiens_hsa040200.90824120
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89718735
57VEGF signaling pathway_Homo sapiens_hsa043700.86399275
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.85575924
59Melanogenesis_Homo sapiens_hsa049160.82637793
60Type II diabetes mellitus_Homo sapiens_hsa049300.82090717
61Cholinergic synapse_Homo sapiens_hsa047250.79546640
62Dopaminergic synapse_Homo sapiens_hsa047280.79084744
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78582779
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.77963288
65Focal adhesion_Homo sapiens_hsa045100.77945432
66Insulin resistance_Homo sapiens_hsa049310.76485128
67Insulin signaling pathway_Homo sapiens_hsa049100.73897149
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.73412622
69Glycerolipid metabolism_Homo sapiens_hsa005610.72991415
70Histidine metabolism_Homo sapiens_hsa003400.72843664
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71555080
72Fatty acid elongation_Homo sapiens_hsa000620.70105949
73Vitamin B6 metabolism_Homo sapiens_hsa007500.69716723
74Phenylalanine metabolism_Homo sapiens_hsa003600.69332897
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68480047
76ErbB signaling pathway_Homo sapiens_hsa040120.68425838
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67905553
78MAPK signaling pathway_Homo sapiens_hsa040100.67880486
79cAMP signaling pathway_Homo sapiens_hsa040240.66603193
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66473280
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65550693
82GnRH signaling pathway_Homo sapiens_hsa049120.63397074
83Mineral absorption_Homo sapiens_hsa049780.60870003
84Complement and coagulation cascades_Homo sapiens_hsa046100.59684731
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.58793948
86Alzheimers disease_Homo sapiens_hsa050100.58612095
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57461763
88Cocaine addiction_Homo sapiens_hsa050300.56211916
89AMPK signaling pathway_Homo sapiens_hsa041520.56165418
90Parkinsons disease_Homo sapiens_hsa050120.55719121
91Taste transduction_Homo sapiens_hsa047420.55647641
92Amoebiasis_Homo sapiens_hsa051460.55535136
93Endocytosis_Homo sapiens_hsa041440.55273483
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.54716920
95ABC transporters_Homo sapiens_hsa020100.54466974
96Fat digestion and absorption_Homo sapiens_hsa049750.53542065
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52405753
98mTOR signaling pathway_Homo sapiens_hsa041500.52153021
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52133025
100ECM-receptor interaction_Homo sapiens_hsa045120.51799403
101Rap1 signaling pathway_Homo sapiens_hsa040150.51468025
102Oxidative phosphorylation_Homo sapiens_hsa001900.50589942
103Pancreatic secretion_Homo sapiens_hsa049720.50433386
104Choline metabolism in cancer_Homo sapiens_hsa052310.49556521
105Inositol phosphate metabolism_Homo sapiens_hsa005620.49257122
106Pentose phosphate pathway_Homo sapiens_hsa000300.49188198
107Arginine and proline metabolism_Homo sapiens_hsa003300.48923763
108Caffeine metabolism_Homo sapiens_hsa002320.48831899
109Endometrial cancer_Homo sapiens_hsa052130.48821716
110Gap junction_Homo sapiens_hsa045400.48490610
111Axon guidance_Homo sapiens_hsa043600.48154136
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46007665
113Tight junction_Homo sapiens_hsa045300.45678825
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45255972
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44480519
116Serotonergic synapse_Homo sapiens_hsa047260.43947685
117Fructose and mannose metabolism_Homo sapiens_hsa000510.43432448
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43189162
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.43126099
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42017780
121Estrogen signaling pathway_Homo sapiens_hsa049150.41819153
122Phagosome_Homo sapiens_hsa041450.41640479
123Thyroid hormone synthesis_Homo sapiens_hsa049180.41367393
124Long-term depression_Homo sapiens_hsa047300.41097703
125Dorso-ventral axis formation_Homo sapiens_hsa043200.40861128
126Ras signaling pathway_Homo sapiens_hsa040140.40125419
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39970322
128Tyrosine metabolism_Homo sapiens_hsa003500.39887335
129Sulfur metabolism_Homo sapiens_hsa009200.39713508
130Renal cell carcinoma_Homo sapiens_hsa052110.39266584
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.38733620
132Circadian rhythm_Homo sapiens_hsa047100.38340214
133Collecting duct acid secretion_Homo sapiens_hsa049660.38121464

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