

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal large subunit biogenesis (GO:0042273) | 5.19756599 |
| 2 | ribosomal small subunit assembly (GO:0000028) | 5.17537985 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 5.14329931 |
| 4 | viral transcription (GO:0019083) | 5.01950373 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.93165232 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 4.88495654 |
| 7 | translational termination (GO:0006415) | 4.87332799 |
| 8 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.38093557 |
| 9 | translational elongation (GO:0006414) | 4.25113334 |
| 10 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.19479489 |
| 11 | CENP-A containing nucleosome assembly (GO:0034080) | 4.18933041 |
| 12 | chromatin remodeling at centromere (GO:0031055) | 4.14713117 |
| 13 | DNA replication checkpoint (GO:0000076) | 4.14517865 |
| 14 | cotranslational protein targeting to membrane (GO:0006613) | 4.14425060 |
| 15 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.12292709 |
| 16 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.12164307 |
| 17 | proteasome assembly (GO:0043248) | 4.12051956 |
| 18 | translational initiation (GO:0006413) | 4.11536752 |
| 19 | protein targeting to ER (GO:0045047) | 4.09493610 |
| 20 | DNA deamination (GO:0045006) | 4.06084217 |
| 21 | DNA replication initiation (GO:0006270) | 4.00099709 |
| 22 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.99973285 |
| 23 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.96315065 |
| 24 | rRNA processing (GO:0006364) | 3.96259878 |
| 25 | DNA strand elongation (GO:0022616) | 3.95350643 |
| 26 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.95053975 |
| 27 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.93592570 |
| 28 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.88266788 |
| 29 | protein localization to endoplasmic reticulum (GO:0070972) | 3.85484687 |
| 30 | cellular protein complex disassembly (GO:0043624) | 3.85222405 |
| 31 | regulation of mitochondrial translation (GO:0070129) | 3.82485572 |
| 32 | rRNA metabolic process (GO:0016072) | 3.82179588 |
| 33 | establishment of viral latency (GO:0019043) | 3.80435878 |
| 34 | kinetochore organization (GO:0051383) | 3.79611439 |
| 35 | viral life cycle (GO:0019058) | 3.79470830 |
| 36 | spliceosomal snRNP assembly (GO:0000387) | 3.72430468 |
| 37 | * mitotic metaphase plate congression (GO:0007080) | 3.69657467 |
| 38 | DNA unwinding involved in DNA replication (GO:0006268) | 3.62889361 |
| 39 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.62825474 |
| 40 | termination of RNA polymerase III transcription (GO:0006386) | 3.62825474 |
| 41 | nucleobase biosynthetic process (GO:0046112) | 3.61295933 |
| 42 | telomere maintenance via recombination (GO:0000722) | 3.59731184 |
| 43 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.58899876 |
| 44 | DNA replication-independent nucleosome organization (GO:0034724) | 3.58899876 |
| 45 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.58617291 |
| 46 | meiotic chromosome segregation (GO:0045132) | 3.58362109 |
| 47 | protein localization to chromosome, centromeric region (GO:0071459) | 3.56828783 |
| 48 | ATP synthesis coupled proton transport (GO:0015986) | 3.56277600 |
| 49 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.56277600 |
| 50 | formation of translation preinitiation complex (GO:0001731) | 3.53891967 |
| 51 | kinetochore assembly (GO:0051382) | 3.53411948 |
| 52 | rRNA modification (GO:0000154) | 3.51919557 |
| 53 | translation (GO:0006412) | 3.49058914 |
| 54 | ribosome assembly (GO:0042255) | 3.47984841 |
| 55 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.47934281 |
| 56 | ribosome biogenesis (GO:0042254) | 3.47631482 |
| 57 | spliceosomal complex assembly (GO:0000245) | 3.45120443 |
| 58 | protein targeting to mitochondrion (GO:0006626) | 3.44143263 |
| 59 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.44118111 |
| 60 | transcription from mitochondrial promoter (GO:0006390) | 3.42446304 |
| 61 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.42352746 |
| 62 | 7-methylguanosine mRNA capping (GO:0006370) | 3.41622177 |
| 63 | pseudouridine synthesis (GO:0001522) | 3.41572028 |
| 64 | * metaphase plate congression (GO:0051310) | 3.40519208 |
| 65 | IMP metabolic process (GO:0046040) | 3.40048934 |
| 66 | protein complex disassembly (GO:0043241) | 3.39706216 |
| 67 | histone exchange (GO:0043486) | 3.39477360 |
| 68 | mitochondrial RNA metabolic process (GO:0000959) | 3.37828339 |
| 69 | * telomere maintenance via telomere lengthening (GO:0010833) | 3.37273304 |
| 70 | cellular component biogenesis (GO:0044085) | 3.37235813 |
| 71 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.37031850 |
| 72 | mitotic recombination (GO:0006312) | 3.36901962 |
| 73 | maturation of 5.8S rRNA (GO:0000460) | 3.36714754 |
| 74 | positive regulation of ligase activity (GO:0051351) | 3.36311981 |
| 75 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.36158882 |
| 76 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.36158882 |
| 77 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.35988775 |
| 78 | RNA capping (GO:0036260) | 3.35713215 |
| 79 | 7-methylguanosine RNA capping (GO:0009452) | 3.35713215 |
| 80 | mitotic sister chromatid segregation (GO:0000070) | 3.35082446 |
| 81 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.35080130 |
| 82 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.34440095 |
| 83 | establishment of integrated proviral latency (GO:0075713) | 3.33561655 |
| 84 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.32837751 |
| 85 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.30454854 |
| 86 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.30112758 |
| 87 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.29028250 |
| 88 | protein neddylation (GO:0045116) | 3.28102823 |
| 89 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.25752383 |
| 90 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.23935988 |
| 91 | macromolecular complex disassembly (GO:0032984) | 3.23401675 |
| 92 | purine nucleobase biosynthetic process (GO:0009113) | 3.23180458 |
| 93 | non-recombinational repair (GO:0000726) | 3.21717149 |
| 94 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.21717149 |
| 95 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.21381599 |
| 96 | tRNA aminoacylation for protein translation (GO:0006418) | 3.20466757 |
| 97 | tRNA aminoacylation (GO:0043039) | 3.19994254 |
| 98 | amino acid activation (GO:0043038) | 3.19994254 |
| 99 | DNA ligation (GO:0006266) | 3.19356696 |
| 100 | termination of RNA polymerase I transcription (GO:0006363) | 3.19048591 |
| 101 | transcription from RNA polymerase I promoter (GO:0006360) | 3.18254027 |
| 102 | regulation of ligase activity (GO:0051340) | 3.16904534 |
| 103 | mRNA catabolic process (GO:0006402) | 3.16707017 |
| 104 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.15380576 |
| 105 | negative regulation of ligase activity (GO:0051352) | 3.15380576 |
| 106 | negative regulation of chromosome segregation (GO:0051985) | 3.14325837 |
| 107 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.13428863 |
| 108 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.12598651 |
| 109 | cell cycle G1/S phase transition (GO:0044843) | 3.12598651 |
| 110 | establishment of protein localization to mitochondrion (GO:0072655) | 3.12522816 |
| 111 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.12000215 |
| 112 | negative regulation of sister chromatid segregation (GO:0033046) | 3.12000215 |
| 113 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.12000215 |
| 114 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.12000215 |
| 115 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.12000215 |
| 116 | mitotic spindle checkpoint (GO:0071174) | 3.10383687 |
| 117 | protein localization to mitochondrion (GO:0070585) | 3.09529880 |
| 118 | RNA catabolic process (GO:0006401) | 3.07683103 |
| 119 | viral mRNA export from host cell nucleus (GO:0046784) | 3.06189816 |
| 120 | * establishment of chromosome localization (GO:0051303) | 3.04463056 |
| 121 | histone mRNA metabolic process (GO:0008334) | 3.03378268 |
| 122 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.02181487 |
| 123 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.02181487 |
| 124 | protein localization to kinetochore (GO:0034501) | 2.99926922 |
| 125 | ncRNA processing (GO:0034470) | 2.99254472 |
| 126 | mitotic nuclear envelope disassembly (GO:0007077) | 2.96386168 |
| 127 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.96112382 |
| 128 | regulation of spindle organization (GO:0090224) | 2.95296696 |
| 129 | rRNA methylation (GO:0031167) | 2.95235300 |
| 130 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.94910832 |
| 131 | DNA damage response, detection of DNA damage (GO:0042769) | 2.94894183 |
| 132 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.94073640 |
| 133 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.94073640 |
| 134 | spindle checkpoint (GO:0031577) | 2.91468525 |
| 135 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.90040666 |
| 136 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.90040666 |
| 137 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 2.89347550 |
| 138 | IMP biosynthetic process (GO:0006188) | 2.88650537 |
| 139 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.87477769 |
| 140 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.87477769 |
| 141 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.87477769 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.32809097 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.70872893 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.22042560 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.69731543 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.67912975 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.58893270 |
| 7 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.51560943 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.47253466 |
| 9 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.40512845 |
| 10 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.35507124 |
| 11 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.31487314 |
| 12 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.31397155 |
| 13 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.23644125 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.05804291 |
| 15 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.00271478 |
| 16 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.98182140 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.94924266 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.80335170 |
| 19 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.55452071 |
| 20 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.52455790 |
| 21 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.50999053 |
| 22 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.47986309 |
| 23 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.45806059 |
| 24 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.41947153 |
| 25 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.39556501 |
| 26 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35357639 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.21441193 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.15548043 |
| 29 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.11910812 |
| 30 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.10920863 |
| 31 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.09851712 |
| 32 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.08611713 |
| 33 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.04349366 |
| 34 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.98987863 |
| 35 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.91934438 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.91177006 |
| 37 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.83054644 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.81376122 |
| 39 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.80566712 |
| 40 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.75432947 |
| 41 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.75063459 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.73741970 |
| 43 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.72571675 |
| 44 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.71215552 |
| 45 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.70696703 |
| 46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.68532476 |
| 47 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.64697233 |
| 48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.59950029 |
| 49 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.59561494 |
| 50 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.57245318 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.55089967 |
| 52 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.54842051 |
| 53 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.53570008 |
| 54 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.48956325 |
| 55 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.45878612 |
| 56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.44418927 |
| 57 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.39832751 |
| 58 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.36390785 |
| 59 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.34270865 |
| 60 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.32884592 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.31599919 |
| 62 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.30089611 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.29681058 |
| 64 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.25863226 |
| 65 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.25708492 |
| 66 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.24783031 |
| 67 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.24091609 |
| 68 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.22187458 |
| 69 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.19865228 |
| 70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.19134442 |
| 71 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.14781496 |
| 72 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10927775 |
| 73 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.09610616 |
| 74 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.00579716 |
| 75 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.00476973 |
| 76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.96387733 |
| 77 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.94351924 |
| 78 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.94036628 |
| 79 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.93151270 |
| 80 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.93100089 |
| 81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.92679923 |
| 82 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.91236612 |
| 83 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.91231916 |
| 84 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.91059452 |
| 85 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.89797860 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.89435402 |
| 87 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.88420102 |
| 88 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.88121883 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.87469542 |
| 90 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.85291131 |
| 91 | MYC_22102868_ChIP-Seq_BL_Human | 0.82131722 |
| 92 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.81472145 |
| 93 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.81007160 |
| 94 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.80243819 |
| 95 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.79887101 |
| 96 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.79282646 |
| 97 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.78011469 |
| 98 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.77392877 |
| 99 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.77280998 |
| 100 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.76033082 |
| 101 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.75675291 |
| 102 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.74151761 |
| 103 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.73270005 |
| 104 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72201991 |
| 105 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.69239568 |
| 106 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.68754792 |
| 107 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.68556014 |
| 108 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.65486303 |
| 109 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.64709783 |
| 110 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.64514972 |
| 111 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.63515394 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.20510807 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.39424398 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.37275187 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.02660376 |
| 5 | MP0003077_abnormal_cell_cycle | 3.78414485 |
| 6 | MP0008058_abnormal_DNA_repair | 3.66744694 |
| 7 | MP0008057_abnormal_DNA_replication | 3.41972728 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.08166035 |
| 9 | MP0009379_abnormal_foot_pigmentation | 2.87992838 |
| 10 | MP0003123_paternal_imprinting | 2.64010285 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.60472094 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.50779150 |
| 13 | MP0002396_abnormal_hematopoietic_system | 2.32760584 |
| 14 | MP0003718_maternal_effect | 2.20400455 |
| 15 | MP0003786_premature_aging | 2.05666393 |
| 16 | MP0003315_abnormal_perineum_morphology | 2.05133065 |
| 17 | MP0000350_abnormal_cell_proliferation | 1.92363564 |
| 18 | MP0001730_embryonic_growth_arrest | 1.91894149 |
| 19 | MP0000490_abnormal_crypts_of | 1.91817229 |
| 20 | MP0009333_abnormal_splenocyte_physiolog | 1.52811648 |
| 21 | MP0001697_abnormal_embryo_size | 1.49546790 |
| 22 | MP0010030_abnormal_orbit_morphology | 1.47440302 |
| 23 | MP0001672_abnormal_embryogenesis/_devel | 1.46513924 |
| 24 | MP0005380_embryogenesis_phenotype | 1.46513924 |
| 25 | MP0000313_abnormal_cell_death | 1.46445910 |
| 26 | MP0003121_genomic_imprinting | 1.45919247 |
| 27 | MP0000358_abnormal_cell_content/ | 1.41556861 |
| 28 | MP0006292_abnormal_olfactory_placode | 1.40875430 |
| 29 | MP0002132_abnormal_respiratory_system | 1.39877878 |
| 30 | MP0001293_anophthalmia | 1.33871869 |
| 31 | MP0002085_abnormal_embryonic_tissue | 1.33739373 |
| 32 | MP0002254_reproductive_system_inflammat | 1.32781214 |
| 33 | MP0000372_irregular_coat_pigmentation | 1.31903581 |
| 34 | MP0002080_prenatal_lethality | 1.31766010 |
| 35 | MP0003984_embryonic_growth_retardation | 1.29249583 |
| 36 | MP0004808_abnormal_hematopoietic_stem | 1.25806767 |
| 37 | MP0002019_abnormal_tumor_incidence | 1.25770611 |
| 38 | MP0002088_abnormal_embryonic_growth/wei | 1.24634764 |
| 39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.23819184 |
| 40 | MP0002210_abnormal_sex_determination | 1.22954180 |
| 41 | MP0003763_abnormal_thymus_physiology | 1.21096998 |
| 42 | MP0002102_abnormal_ear_morphology | 1.17870091 |
| 43 | MP0002877_abnormal_melanocyte_morpholog | 1.16104869 |
| 44 | MP0003221_abnormal_cardiomyocyte_apopto | 1.10411159 |
| 45 | MP0002084_abnormal_developmental_patter | 1.09071612 |
| 46 | MP0000703_abnormal_thymus_morphology | 1.08275923 |
| 47 | MP0002398_abnormal_bone_marrow | 1.06142890 |
| 48 | MP0003186_abnormal_redox_activity | 1.05694080 |
| 49 | MP0001145_abnormal_male_reproductive | 1.04341255 |
| 50 | MP0003787_abnormal_imprinting | 1.03676961 |
| 51 | MP0005499_abnormal_olfactory_system | 1.02690964 |
| 52 | MP0005394_taste/olfaction_phenotype | 1.02690964 |
| 53 | MP0005395_other_phenotype | 0.98657450 |
| 54 | MP0005075_abnormal_melanosome_morpholog | 0.97766088 |
| 55 | MP0009672_abnormal_birth_weight | 0.96041789 |
| 56 | MP0006072_abnormal_retinal_apoptosis | 0.95886279 |
| 57 | MP0002722_abnormal_immune_system | 0.94327577 |
| 58 | MP0002086_abnormal_extraembryonic_tissu | 0.93919718 |
| 59 | MP0003937_abnormal_limbs/digits/tail_de | 0.93711264 |
| 60 | MP0000653_abnormal_sex_gland | 0.93495043 |
| 61 | MP0000689_abnormal_spleen_morphology | 0.92478053 |
| 62 | MP0001929_abnormal_gametogenesis | 0.91975745 |
| 63 | MP0001881_abnormal_mammary_gland | 0.91661700 |
| 64 | MP0001853_heart_inflammation | 0.89977238 |
| 65 | MP0004133_heterotaxia | 0.89106813 |
| 66 | MP0003136_yellow_coat_color | 0.88553156 |
| 67 | MP0001764_abnormal_homeostasis | 0.87900873 |
| 68 | MP0009697_abnormal_copulation | 0.87165283 |
| 69 | MP0003938_abnormal_ear_development | 0.86615031 |
| 70 | MP0004197_abnormal_fetal_growth/weight/ | 0.86461955 |
| 71 | MP0001119_abnormal_female_reproductive | 0.86422550 |
| 72 | MP0005501_abnormal_skin_physiology | 0.86242382 |
| 73 | MP0004782_abnormal_surfactant_physiolog | 0.85809918 |
| 74 | MP0002429_abnormal_blood_cell | 0.85673207 |
| 75 | MP0003941_abnormal_skin_development | 0.84830378 |
| 76 | MP0001727_abnormal_embryo_implantation | 0.84519167 |
| 77 | MP0010307_abnormal_tumor_latency | 0.84183758 |
| 78 | MP0001188_hyperpigmentation | 0.84103372 |
| 79 | MP0003890_abnormal_embryonic-extraembry | 0.81229718 |
| 80 | MP0000858_altered_metastatic_potential | 0.80594808 |
| 81 | MP0001286_abnormal_eye_development | 0.80429726 |
| 82 | MP0002163_abnormal_gland_morphology | 0.79851461 |
| 83 | MP0000716_abnormal_immune_system | 0.79642604 |
| 84 | MP0003806_abnormal_nucleotide_metabolis | 0.78579496 |
| 85 | MP0005384_cellular_phenotype | 0.78302423 |
| 86 | MP0002111_abnormal_tail_morphology | 0.77914955 |
| 87 | MP0000566_synostosis | 0.77050685 |
| 88 | MP0002796_impaired_skin_barrier | 0.75788833 |
| 89 | MP0008260_abnormal_autophagy | 0.75354848 |
| 90 | MP0002938_white_spotting | 0.74861212 |
| 91 | MP0005408_hypopigmentation | 0.73402218 |
| 92 | MP0002160_abnormal_reproductive_system | 0.71485160 |
| 93 | MP0003119_abnormal_digestive_system | 0.70990169 |
| 94 | MP0003011_delayed_dark_adaptation | 0.70973293 |
| 95 | MP0005451_abnormal_body_composition | 0.70738371 |
| 96 | MP0001529_abnormal_vocalization | 0.70279456 |
| 97 | MP0001800_abnormal_humoral_immune | 0.68764687 |
| 98 | MP0006036_abnormal_mitochondrial_physio | 0.68408617 |
| 99 | MP0000049_abnormal_middle_ear | 0.67379555 |
| 100 | MP0005389_reproductive_system_phenotype | 0.66958469 |
| 101 | MP0006035_abnormal_mitochondrial_morpho | 0.66178729 |
| 102 | MP0006054_spinal_hemorrhage | 0.65999264 |
| 103 | MP0010352_gastrointestinal_tract_polyps | 0.65884490 |
| 104 | MP0000678_abnormal_parathyroid_gland | 0.64169667 |
| 105 | MP0000432_abnormal_head_morphology | 0.63941220 |
| 106 | MP0002420_abnormal_adaptive_immunity | 0.63377780 |
| 107 | MP0002452_abnormal_antigen_presenting | 0.63367608 |
| 108 | MP0002723_abnormal_immune_serum | 0.62789645 |
| 109 | MP0005397_hematopoietic_system_phenotyp | 0.62721169 |
| 110 | MP0001545_abnormal_hematopoietic_system | 0.62721169 |
| 111 | MP0008789_abnormal_olfactory_epithelium | 0.62618641 |
| 112 | MP0005671_abnormal_response_to | 0.62604430 |
| 113 | MP0002092_abnormal_eye_morphology | 0.62399724 |
| 114 | MP0001819_abnormal_immune_cell | 0.62167454 |
| 115 | MP0001835_abnormal_antigen_presentation | 0.61974354 |
| 116 | MP0009053_abnormal_anal_canal | 0.61714752 |
| 117 | MP0002095_abnormal_skin_pigmentation | 0.61048342 |
| 118 | MP0001986_abnormal_taste_sensitivity | 0.60741932 |
| 119 | MP0003936_abnormal_reproductive_system | 0.60534560 |
| 120 | MP0000613_abnormal_salivary_gland | 0.60366756 |
| 121 | MP0005621_abnormal_cell_physiology | 0.59226202 |
| 122 | MP0005266_abnormal_metabolism | 0.58608277 |
| 123 | MP0003699_abnormal_female_reproductive | 0.58124245 |
| 124 | MP0002697_abnormal_eye_size | 0.57128932 |
| 125 | MP0002233_abnormal_nose_morphology | 0.56230737 |
| 126 | MP0000627_abnormal_mammary_gland | 0.56076442 |
| 127 | MP0000579_abnormal_nail_morphology | 0.54465638 |
| 128 | MP0001346_abnormal_lacrimal_gland | 0.54310090 |
| 129 | MP0002277_abnormal_respiratory_mucosa | 0.52770378 |
| 130 | MP0001177_atelectasis | 0.52579580 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.30963190 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 5.07836729 |
| 3 | Birth length less than 3rd percentile (HP:0003561) | 4.90039875 |
| 4 | Reticulocytopenia (HP:0001896) | 4.67007298 |
| 5 | Acute encephalopathy (HP:0006846) | 4.07202385 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.06872823 |
| 7 | Macrocytic anemia (HP:0001972) | 3.75360886 |
| 8 | Breast hypoplasia (HP:0003187) | 3.69074150 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.48232045 |
| 10 | Increased hepatocellular lipid droplets (HP:0006565) | 3.48167903 |
| 11 | Pallor (HP:0000980) | 3.43073795 |
| 12 | Chromsome breakage (HP:0040012) | 3.36383488 |
| 13 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.31971457 |
| 14 | Oral leukoplakia (HP:0002745) | 3.23182032 |
| 15 | Multiple enchondromatosis (HP:0005701) | 3.21405205 |
| 16 | Colon cancer (HP:0003003) | 3.11615476 |
| 17 | Cerebral edema (HP:0002181) | 3.08268561 |
| 18 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.03193313 |
| 19 | Abnormality of the anterior horn cell (HP:0006802) | 3.00597398 |
| 20 | Degeneration of anterior horn cells (HP:0002398) | 3.00597398 |
| 21 | Aplastic anemia (HP:0001915) | 2.98655779 |
| 22 | Abnormality of the preputium (HP:0100587) | 2.98381978 |
| 23 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.97679126 |
| 24 | Cerebral hypomyelination (HP:0006808) | 2.86066183 |
| 25 | Exertional dyspnea (HP:0002875) | 2.85003126 |
| 26 | Lipid accumulation in hepatocytes (HP:0006561) | 2.77386609 |
| 27 | Rough bone trabeculation (HP:0100670) | 2.77327301 |
| 28 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.69223109 |
| 29 | Lactic acidosis (HP:0003128) | 2.68567552 |
| 30 | Patellar aplasia (HP:0006443) | 2.68433175 |
| 31 | Increased serum lactate (HP:0002151) | 2.67395330 |
| 32 | Mitochondrial inheritance (HP:0001427) | 2.64736181 |
| 33 | Abnormality of methionine metabolism (HP:0010901) | 2.64393959 |
| 34 | Hepatocellular necrosis (HP:0001404) | 2.63618603 |
| 35 | Meckel diverticulum (HP:0002245) | 2.62180601 |
| 36 | Microvesicular hepatic steatosis (HP:0001414) | 2.61134798 |
| 37 | Amniotic constriction ring (HP:0009775) | 2.60957262 |
| 38 | Abnormality of placental membranes (HP:0011409) | 2.60957262 |
| 39 | Carpal bone hypoplasia (HP:0001498) | 2.57435294 |
| 40 | Increased CSF lactate (HP:0002490) | 2.56176646 |
| 41 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.53031856 |
| 42 | Triphalangeal thumb (HP:0001199) | 2.52862745 |
| 43 | Renal Fanconi syndrome (HP:0001994) | 2.52812155 |
| 44 | Rib fusion (HP:0000902) | 2.51412058 |
| 45 | Pancytopenia (HP:0001876) | 2.51400291 |
| 46 | Abnormality of chromosome stability (HP:0003220) | 2.49990498 |
| 47 | Abnormality of the ileum (HP:0001549) | 2.43590906 |
| 48 | Respiratory failure (HP:0002878) | 2.43556221 |
| 49 | Megaloblastic anemia (HP:0001889) | 2.42149763 |
| 50 | 3-Methylglutaconic aciduria (HP:0003535) | 2.41650394 |
| 51 | IgM deficiency (HP:0002850) | 2.40611993 |
| 52 | Increased muscle lipid content (HP:0009058) | 2.40218983 |
| 53 | Absent radius (HP:0003974) | 2.40035211 |
| 54 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.39977259 |
| 55 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.39977259 |
| 56 | Progressive external ophthalmoplegia (HP:0000590) | 2.38034908 |
| 57 | Premature graying of hair (HP:0002216) | 2.36585503 |
| 58 | Leukodystrophy (HP:0002415) | 2.35992734 |
| 59 | Abnormality of glycolysis (HP:0004366) | 2.31595348 |
| 60 | Increased serum pyruvate (HP:0003542) | 2.31595348 |
| 61 | Absent thumb (HP:0009777) | 2.30527252 |
| 62 | Cleft eyelid (HP:0000625) | 2.29280975 |
| 63 | Abnormal lung lobation (HP:0002101) | 2.29240867 |
| 64 | Horseshoe kidney (HP:0000085) | 2.27594708 |
| 65 | Myelodysplasia (HP:0002863) | 2.27515916 |
| 66 | Progressive muscle weakness (HP:0003323) | 2.25413209 |
| 67 | Overlapping toe (HP:0001845) | 2.23687670 |
| 68 | Aplasia involving forearm bones (HP:0009822) | 2.22579735 |
| 69 | Absent forearm bone (HP:0003953) | 2.22579735 |
| 70 | Secondary amenorrhea (HP:0000869) | 2.22053169 |
| 71 | Microretrognathia (HP:0000308) | 2.21544043 |
| 72 | Reduced antithrombin III activity (HP:0001976) | 2.18422009 |
| 73 | Respiratory difficulties (HP:0002880) | 2.17584925 |
| 74 | Hepatic necrosis (HP:0002605) | 2.17295589 |
| 75 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.16677473 |
| 76 | Medulloblastoma (HP:0002885) | 2.13235236 |
| 77 | Abnormal trabecular bone morphology (HP:0100671) | 2.12556005 |
| 78 | Abnormal hemoglobin (HP:0011902) | 2.11179294 |
| 79 | Selective tooth agenesis (HP:0001592) | 2.09974989 |
| 80 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.09237085 |
| 81 | Abnormality of serum amino acid levels (HP:0003112) | 2.08416683 |
| 82 | Acute necrotizing encephalopathy (HP:0006965) | 2.07833070 |
| 83 | Duodenal stenosis (HP:0100867) | 2.07740649 |
| 84 | Small intestinal stenosis (HP:0012848) | 2.07740649 |
| 85 | Hyperglycinemia (HP:0002154) | 2.06863567 |
| 86 | Impulsivity (HP:0100710) | 2.06216105 |
| 87 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.05902363 |
| 88 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.05902363 |
| 89 | Single umbilical artery (HP:0001195) | 2.05902363 |
| 90 | Agnosia (HP:0010524) | 2.05403018 |
| 91 | Type 2 muscle fiber atrophy (HP:0003554) | 2.05309087 |
| 92 | Cellular immunodeficiency (HP:0005374) | 2.04754217 |
| 93 | Methylmalonic acidemia (HP:0002912) | 2.04720681 |
| 94 | Stenosis of the external auditory canal (HP:0000402) | 2.02053996 |
| 95 | Abnormality of the umbilical cord (HP:0010881) | 2.01508770 |
| 96 | Methylmalonic aciduria (HP:0012120) | 2.01475173 |
| 97 | Squamous cell carcinoma (HP:0002860) | 2.01379035 |
| 98 | Muscle fiber atrophy (HP:0100295) | 2.01116756 |
| 99 | Type I transferrin isoform profile (HP:0003642) | 1.98773458 |
| 100 | Thrombocytosis (HP:0001894) | 1.98763857 |
| 101 | Sparse eyelashes (HP:0000653) | 1.96915872 |
| 102 | 11 pairs of ribs (HP:0000878) | 1.96690996 |
| 103 | Patchy hypopigmentation of hair (HP:0011365) | 1.96110306 |
| 104 | Duplicated collecting system (HP:0000081) | 1.95904926 |
| 105 | Premature ovarian failure (HP:0008209) | 1.94123390 |
| 106 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.93260480 |
| 107 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.93260480 |
| 108 | Abnormal protein glycosylation (HP:0012346) | 1.93260480 |
| 109 | Abnormal glycosylation (HP:0012345) | 1.93260480 |
| 110 | Facial cleft (HP:0002006) | 1.92151043 |
| 111 | Short middle phalanx of the 5th finger (HP:0004220) | 1.92009065 |
| 112 | Bone marrow hypocellularity (HP:0005528) | 1.91605692 |
| 113 | Spastic diplegia (HP:0001264) | 1.90445694 |
| 114 | Abnormality of alanine metabolism (HP:0010916) | 1.89643021 |
| 115 | Hyperalaninemia (HP:0003348) | 1.89643021 |
| 116 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.89643021 |
| 117 | Nausea (HP:0002018) | 1.88944605 |
| 118 | Spinal muscular atrophy (HP:0007269) | 1.88774797 |
| 119 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.88755752 |
| 120 | Rectal fistula (HP:0100590) | 1.87878409 |
| 121 | Rectovaginal fistula (HP:0000143) | 1.87878409 |
| 122 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.87525686 |
| 123 | Trismus (HP:0000211) | 1.87494336 |
| 124 | Exercise intolerance (HP:0003546) | 1.86898285 |
| 125 | Neoplasm of the pancreas (HP:0002894) | 1.86519925 |
| 126 | Abnormality of the labia minora (HP:0012880) | 1.85989964 |
| 127 | Abnormality of the duodenum (HP:0002246) | 1.85967492 |
| 128 | Short thumb (HP:0009778) | 1.85449669 |
| 129 | Lymphoma (HP:0002665) | 1.85029022 |
| 130 | Sloping forehead (HP:0000340) | 1.84789049 |
| 131 | Abnormal number of incisors (HP:0011064) | 1.83362218 |
| 132 | Rhabdomyosarcoma (HP:0002859) | 1.82923082 |
| 133 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.81683908 |
| 134 | Increased intramyocellular lipid droplets (HP:0012240) | 1.80818814 |
| 135 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.80025638 |
| 136 | Ectopic kidney (HP:0000086) | 1.79885979 |
| 137 | Hypoplasia of the radius (HP:0002984) | 1.79602620 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.38864998 |
| 2 | EIF2AK1 | 3.97759046 |
| 3 | VRK2 | 3.85317596 |
| 4 | CDC7 | 3.53221524 |
| 5 | WEE1 | 3.32694027 |
| 6 | TLK1 | 3.05950797 |
| 7 | NME2 | 2.97519563 |
| 8 | VRK1 | 2.76537606 |
| 9 | SRPK1 | 2.61717198 |
| 10 | MKNK1 | 2.55632402 |
| 11 | EIF2AK3 | 2.52103366 |
| 12 | STK16 | 2.49726030 |
| 13 | PLK4 | 2.42632541 |
| 14 | TSSK6 | 2.36261553 |
| 15 | MKNK2 | 2.03595106 |
| 16 | TTK | 1.92955424 |
| 17 | TAF1 | 1.88675321 |
| 18 | NME1 | 1.88536606 |
| 19 | CASK | 1.81900083 |
| 20 | * PLK1 | 1.73533438 |
| 21 | NEK2 | 1.65601287 |
| 22 | AURKB | 1.62316834 |
| 23 | PLK3 | 1.60361408 |
| 24 | CDK7 | 1.59626513 |
| 25 | DYRK3 | 1.58972555 |
| 26 | RPS6KA4 | 1.57468486 |
| 27 | TRIM28 | 1.56022103 |
| 28 | RPS6KB2 | 1.53169765 |
| 29 | PBK | 1.43305413 |
| 30 | NUAK1 | 1.42927640 |
| 31 | ATR | 1.40661736 |
| 32 | EIF2AK2 | 1.34794568 |
| 33 | STK10 | 1.30634319 |
| 34 | MST4 | 1.29892305 |
| 35 | STK38L | 1.25105741 |
| 36 | AURKA | 1.24715528 |
| 37 | IRAK4 | 1.18104574 |
| 38 | CHEK2 | 1.16972309 |
| 39 | PIM2 | 1.13380281 |
| 40 | PDK2 | 1.11248932 |
| 41 | BRSK2 | 1.11094079 |
| 42 | CDK12 | 1.10827063 |
| 43 | SMG1 | 1.05648540 |
| 44 | NEK1 | 1.04957894 |
| 45 | BRAF | 1.02939189 |
| 46 | CDK4 | 1.00541439 |
| 47 | TESK2 | 0.99455836 |
| 48 | PASK | 0.99347011 |
| 49 | EPHA2 | 0.98379268 |
| 50 | SCYL2 | 0.97906630 |
| 51 | MAP3K8 | 0.96240413 |
| 52 | CHEK1 | 0.95494905 |
| 53 | ACVR1B | 0.95137472 |
| 54 | STK4 | 0.92477739 |
| 55 | ZAK | 0.88704413 |
| 56 | PNCK | 0.83745116 |
| 57 | CSNK2A2 | 0.83680227 |
| 58 | CSNK2A1 | 0.81523361 |
| 59 | ATM | 0.80563557 |
| 60 | MAP4K2 | 0.77549408 |
| 61 | TGFBR1 | 0.74379580 |
| 62 | BRSK1 | 0.71011014 |
| 63 | RPS6KA5 | 0.70703608 |
| 64 | PAK1 | 0.68969999 |
| 65 | TNIK | 0.67294581 |
| 66 | BCKDK | 0.66848600 |
| 67 | CDK2 | 0.65172448 |
| 68 | KDR | 0.63658470 |
| 69 | CDK8 | 0.63224310 |
| 70 | PIM1 | 0.62290265 |
| 71 | MAP3K6 | 0.61337781 |
| 72 | MAP2K3 | 0.60816119 |
| 73 | CCNB1 | 0.60718746 |
| 74 | BMPR1B | 0.59962616 |
| 75 | WNK3 | 0.59690461 |
| 76 | DAPK1 | 0.59287574 |
| 77 | MELK | 0.59274899 |
| 78 | MAP4K1 | 0.58309385 |
| 79 | DYRK2 | 0.57648424 |
| 80 | ALK | 0.55763742 |
| 81 | TEC | 0.54838590 |
| 82 | CLK1 | 0.54761214 |
| 83 | CDK1 | 0.53967505 |
| 84 | ERBB4 | 0.53566822 |
| 85 | IRAK3 | 0.52229344 |
| 86 | CSNK1G3 | 0.50281785 |
| 87 | STK24 | 0.48771866 |
| 88 | PAK4 | 0.48626400 |
| 89 | TXK | 0.48625485 |
| 90 | STK3 | 0.46517724 |
| 91 | MARK3 | 0.45986168 |
| 92 | EEF2K | 0.45406875 |
| 93 | NEK9 | 0.44055252 |
| 94 | FGFR1 | 0.43787269 |
| 95 | BLK | 0.43764524 |
| 96 | CSNK1E | 0.42481081 |
| 97 | CDK9 | 0.40920343 |
| 98 | TAOK2 | 0.39981301 |
| 99 | CSNK1G1 | 0.39763959 |
| 100 | MAP2K6 | 0.39568112 |
| 101 | LRRK2 | 0.39423713 |
| 102 | MAPKAPK2 | 0.39321868 |
| 103 | STK39 | 0.39089322 |
| 104 | CDK19 | 0.39016304 |
| 105 | PRKCI | 0.38655650 |
| 106 | BRD4 | 0.38271542 |
| 107 | MAP3K3 | 0.36719294 |
| 108 | ABL2 | 0.35184631 |
| 109 | KIT | 0.33833504 |
| 110 | MAPKAPK5 | 0.33687108 |
| 111 | YES1 | 0.33283660 |
| 112 | CSNK1G2 | 0.32895641 |
| 113 | MUSK | 0.32197357 |
| 114 | BTK | 0.31321495 |
| 115 | MOS | 0.30958277 |
| 116 | AKT2 | 0.30750867 |
| 117 | CSNK1A1L | 0.29634867 |
| 118 | CSF1R | 0.29128891 |
| 119 | IKBKB | 0.28579089 |
| 120 | LYN | 0.28475689 |
| 121 | PRKDC | 0.26702846 |
| 122 | ARAF | 0.25919495 |
| 123 | ILK | 0.25532451 |
| 124 | CDK3 | 0.24415649 |
| 125 | MAP3K10 | 0.24282392 |
| 126 | BMPR2 | 0.24258543 |
| 127 | GRK1 | 0.23794839 |
| 128 | DAPK3 | 0.19918801 |
| 129 | CSNK1A1 | 0.18327655 |
| 130 | TESK1 | 0.16976973 |
| 131 | PLK2 | 0.16913695 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.71610821 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.37159612 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.91204636 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.88303946 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.65731161 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.62469273 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.34066769 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 3.15153178 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.76697131 |
| 10 | RNA transport_Homo sapiens_hsa03013 | 2.70444917 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.62143827 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.61834287 |
| 13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.40878762 |
| 14 | Cell cycle_Homo sapiens_hsa04110 | 2.31536242 |
| 15 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.30426871 |
| 16 | RNA degradation_Homo sapiens_hsa03018 | 2.19470645 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.07081383 |
| 18 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.98101642 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.97201378 |
| 20 | Protein export_Homo sapiens_hsa03060 | 1.77174006 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.64219060 |
| 22 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.57518196 |
| 23 | Purine metabolism_Homo sapiens_hsa00230 | 1.42609706 |
| 24 | Parkinsons disease_Homo sapiens_hsa05012 | 1.40945531 |
| 25 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.39905634 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.37334981 |
| 27 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.34453383 |
| 28 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.32050939 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.27941503 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27570073 |
| 31 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.24101600 |
| 32 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.14784602 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.04533455 |
| 34 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.00053809 |
| 35 | Carbon metabolism_Homo sapiens_hsa01200 | 0.99198006 |
| 36 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.92967392 |
| 37 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.92247203 |
| 38 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.88952990 |
| 39 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.88929505 |
| 40 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.88293262 |
| 41 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.87426291 |
| 42 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.86210811 |
| 43 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.81037776 |
| 44 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.80309970 |
| 45 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.78842952 |
| 46 | Alzheimers disease_Homo sapiens_hsa05010 | 0.78156330 |
| 47 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.76347530 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.73321939 |
| 49 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.66400604 |
| 50 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.65154280 |
| 51 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.65101268 |
| 52 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.64745884 |
| 53 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.64546841 |
| 54 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.63467018 |
| 55 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.63175798 |
| 56 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.61224236 |
| 57 | HTLV-I infection_Homo sapiens_hsa05166 | 0.58874146 |
| 58 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.57827802 |
| 59 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.57769477 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.57244731 |
| 61 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56678713 |
| 62 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.51795588 |
| 63 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.49364101 |
| 64 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.46440451 |
| 65 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.44205331 |
| 66 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.41827794 |
| 67 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.39461451 |
| 68 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.39322304 |
| 69 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.39086409 |
| 70 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.37212454 |
| 71 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.36542814 |
| 72 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.35149063 |
| 73 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.33881650 |
| 74 | Legionellosis_Homo sapiens_hsa05134 | 0.33865914 |
| 75 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.33750968 |
| 76 | Shigellosis_Homo sapiens_hsa05131 | 0.33572248 |
| 77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.33548037 |
| 78 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.32004290 |
| 79 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.31095071 |
| 80 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.30008560 |
| 81 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.29731410 |
| 82 | Apoptosis_Homo sapiens_hsa04210 | 0.29478772 |
| 83 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.28860113 |
| 84 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.28447038 |
| 85 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.28354377 |
| 86 | Hepatitis B_Homo sapiens_hsa05161 | 0.26606178 |
| 87 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.26374358 |
| 88 | Measles_Homo sapiens_hsa05162 | 0.26123578 |
| 89 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.25378293 |
| 90 | Sulfur relay system_Homo sapiens_hsa04122 | 0.25188039 |
| 91 | Galactose metabolism_Homo sapiens_hsa00052 | 0.23471412 |
| 92 | Allograft rejection_Homo sapiens_hsa05330 | 0.23034117 |
| 93 | Peroxisome_Homo sapiens_hsa04146 | 0.21620050 |
| 94 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.21481523 |
| 95 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.21423893 |
| 96 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.21083102 |
| 97 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.20552084 |
| 98 | Alcoholism_Homo sapiens_hsa05034 | 0.18732201 |
| 99 | Pertussis_Homo sapiens_hsa05133 | 0.18079902 |
| 100 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.17998783 |
| 101 | Asthma_Homo sapiens_hsa05310 | 0.17652583 |
| 102 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.17633211 |
| 103 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.17176214 |
| 104 | Phototransduction_Homo sapiens_hsa04744 | 0.16726110 |
| 105 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.16452677 |
| 106 | Thyroid cancer_Homo sapiens_hsa05216 | 0.16035498 |
| 107 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.15861734 |
| 108 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.15688361 |
| 109 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.15394762 |
| 110 | Influenza A_Homo sapiens_hsa05164 | 0.14585369 |
| 111 | Pathways in cancer_Homo sapiens_hsa05200 | 0.13406149 |
| 112 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.13398990 |
| 113 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.12780407 |
| 114 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.12009890 |
| 115 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.11561205 |
| 116 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.11542912 |
| 117 | Leishmaniasis_Homo sapiens_hsa05140 | 0.11369766 |
| 118 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.11093697 |
| 119 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.11041698 |
| 120 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.08365108 |
| 121 | Colorectal cancer_Homo sapiens_hsa05210 | 0.08277739 |
| 122 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.07634475 |
| 123 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.07410210 |
| 124 | Prostate cancer_Homo sapiens_hsa05215 | 0.06920447 |
| 125 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.06125968 |
| 126 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.05640482 |
| 127 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.04714481 |
| 128 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.04111255 |
| 129 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.03202554 |
| 130 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.02983825 |
| 131 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.02337435 |

