PIP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hydrogen peroxide catabolic process (GO:0042744)9.98732745
2mammary gland epithelial cell differentiation (GO:0060644)9.47240528
3primary alcohol catabolic process (GO:0034310)9.46133698
4mitochondrial calcium ion transport (GO:0006851)8.34452072
5mitochondrion distribution (GO:0048311)7.99977697
6ribosome assembly (GO:0042255)7.26747248
7behavioral response to pain (GO:0048266)6.96584051
8phasic smooth muscle contraction (GO:0014821)6.76284258
9Golgi transport vesicle coating (GO:0048200)6.27159046
10COPI coating of Golgi vesicle (GO:0048205)6.27159046
11skeletal muscle fiber development (GO:0048741)6.17947204
12purinergic nucleotide receptor signaling pathway (GO:0035590)6.15261265
13response to water (GO:0009415)6.08860296
14desmosome organization (GO:0002934)5.92549555
15ear development (GO:0043583)5.48073836
16hydrogen peroxide metabolic process (GO:0042743)5.47930142
17peptidyl-tyrosine autophosphorylation (GO:0038083)5.29949202
18signal peptide processing (GO:0006465)5.28192588
19myotube cell development (GO:0014904)5.25961343
20maternal placenta development (GO:0001893)4.92598677
21galactose metabolic process (GO:0006012)4.77033138
22nucleoside diphosphate catabolic process (GO:0009134)4.64298751
23ethanol oxidation (GO:0006069)4.61946880
24valine metabolic process (GO:0006573)4.61702267
25aggressive behavior (GO:0002118)4.57235123
26purinergic receptor signaling pathway (GO:0035587)4.52541363
27response to ATP (GO:0033198)4.35718414
28neuromuscular synaptic transmission (GO:0007274)4.35546659
29regulation of water loss via skin (GO:0033561)4.33450258
30cellular copper ion homeostasis (GO:0006878)4.32698676
31proline metabolic process (GO:0006560)4.32191322
32diol metabolic process (GO:0034311)4.30843424
33negative regulation of cell size (GO:0045792)4.23059520
34transcytosis (GO:0045056)4.22532590
35endothelial cell chemotaxis (GO:0035767)4.20635106
36glycoprotein catabolic process (GO:0006516)4.17703777
37short-chain fatty acid metabolic process (GO:0046459)4.16906504
38hepatocyte apoptotic process (GO:0097284)4.16392010
39regulation of mammary gland epithelial cell proliferation (GO:0033599)4.11719521
40sensory perception of taste (GO:0050909)4.06856145
41glutathione biosynthetic process (GO:0006750)4.06074287
42regulation of autophagic vacuole assembly (GO:2000785)4.04962475
43regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.04377124
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.01319566
45regulation of clathrin-mediated endocytosis (GO:2000369)3.95956475
46branched-chain amino acid catabolic process (GO:0009083)3.95315721
47protein maturation by protein folding (GO:0022417)3.95281511
48alpha-linolenic acid metabolic process (GO:0036109)3.93821733
49protein retention in ER lumen (GO:0006621)3.91120342
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.89277166
51ethanol metabolic process (GO:0006067)3.87971334
52positive regulation of nuclease activity (GO:0032075)3.81864721
53cardiac right ventricle morphogenesis (GO:0003215)3.80495252
54Golgi organization (GO:0007030)3.73436196
55COPII vesicle coating (GO:0048208)3.72881340
56sphingosine metabolic process (GO:0006670)3.72505551
57positive regulation of calcium-mediated signaling (GO:0050850)3.72083490
58nonribosomal peptide biosynthetic process (GO:0019184)3.69906153
59neuronal action potential (GO:0019228)3.64864807
60negative regulation of transcription by competitive promoter binding (GO:0010944)3.64459866
61oocyte development (GO:0048599)3.64377709
62mitochondrion localization (GO:0051646)3.60355592
63branched-chain amino acid metabolic process (GO:0009081)3.57965238
64endoplasmic reticulum unfolded protein response (GO:0030968)3.53818751
65calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.52105875
66UDP-N-acetylglucosamine metabolic process (GO:0006047)3.51655112
67ER-nucleus signaling pathway (GO:0006984)3.48591220
68cell differentiation involved in embryonic placenta development (GO:0060706)3.47883991
69sphingoid metabolic process (GO:0046519)3.47190715
70establishment of skin barrier (GO:0061436)3.46569872
714-hydroxyproline metabolic process (GO:0019471)3.43013834
72regulation of nuclease activity (GO:0032069)3.42091146
73neuromuscular junction development (GO:0007528)3.41817925
74cellular response to unfolded protein (GO:0034620)3.41129176
75response to pain (GO:0048265)3.38218114
76ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.37315317
77retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.37268706
78cytoskeletal anchoring at plasma membrane (GO:0007016)3.37252673
79mammary gland alveolus development (GO:0060749)3.36100025
80regulation of histone H3-K27 methylation (GO:0061085)3.32543439
81vesicle coating (GO:0006901)3.31732269
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.31373461
83acetyl-CoA metabolic process (GO:0006084)3.30283546
84negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.30154482
85cellular protein catabolic process (GO:0044257)3.29887771
86keratinocyte development (GO:0003334)3.28977804
87negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.27542670
88endocardial cushion development (GO:0003197)3.27412730
89regulation of vacuole organization (GO:0044088)3.26181264
90multicellular organismal water homeostasis (GO:0050891)3.26112938
91exocrine pancreas development (GO:0031017)3.26050478
92lysine catabolic process (GO:0006554)3.25535722
93lysine metabolic process (GO:0006553)3.25535722
94* detection of chemical stimulus (GO:0009593)3.25379119
95endocrine hormone secretion (GO:0060986)3.20201953
96zinc ion transport (GO:0006829)3.19121598
97proline biosynthetic process (GO:0006561)3.16864034
98norepinephrine metabolic process (GO:0042415)3.13851684
99negative regulation of microtubule polymerization (GO:0031115)3.12856423
100copper ion homeostasis (GO:0055070)3.12610405
101amyloid precursor protein catabolic process (GO:0042987)3.11947198
102interferon-gamma secretion (GO:0072643)3.11866129
103dicarboxylic acid biosynthetic process (GO:0043650)3.09374508
104cellular response to topologically incorrect protein (GO:0035967)3.07694326
105localization within membrane (GO:0051668)3.06502360
106citrulline biosynthetic process (GO:0019240)3.01996978
107response to unfolded protein (GO:0006986)3.00759040
108lung secretory cell differentiation (GO:0061140)3.00652152
109atrioventricular valve morphogenesis (GO:0003181)3.00566312
110* detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)22.3999269
111response to endoplasmic reticulum stress (GO:0034976)2.99302991
112catechol-containing compound biosynthetic process (GO:0009713)2.99135301
113catecholamine biosynthetic process (GO:0042423)2.99135301
114negative regulation of kidney development (GO:0090185)2.97950808
115protein N-linked glycosylation via asparagine (GO:0018279)2.97927734
116regulation of fatty acid beta-oxidation (GO:0031998)2.97481693
117cellular response to interferon-alpha (GO:0035457)2.97468577
118peptidyl-asparagine modification (GO:0018196)2.96652206
119regulation of cytokine production involved in inflammatory response (GO:1900015)2.95388060
120acyl-CoA biosynthetic process (GO:0071616)2.95321094
121thioester biosynthetic process (GO:0035384)2.95321094
122regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.94830396
123protein targeting to Golgi (GO:0000042)2.94511964
124glandular epithelial cell differentiation (GO:0002067)2.91869429
125negative regulation of response to reactive oxygen species (GO:1901032)2.91396666
126regulation of ruffle assembly (GO:1900027)2.90997272
127epithelial cell-cell adhesion (GO:0090136)2.90936848
128carnitine metabolic process (GO:0009437)2.90902559
129myelin maintenance (GO:0043217)2.90405003
130plasma membrane repair (GO:0001778)2.87119226
131positive regulation of cellular amine metabolic process (GO:0033240)2.86455181
132ectoderm development (GO:0007398)2.84773295
133regulation of hippo signaling (GO:0035330)2.83250039
134carnitine shuttle (GO:0006853)2.82857575
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.82119655
136intestinal epithelial cell development (GO:0060576)2.81536111
137positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.81456799
138peptide biosynthetic process (GO:0043043)2.81243891
139phosphatidylinositol 3-kinase signaling (GO:0014065)2.79856120
140protein N-linked glycosylation (GO:0006487)2.79074607
141ruffle organization (GO:0031529)2.78930417
142positive regulation of glycoprotein metabolic process (GO:1903020)2.78655758
143cellular modified amino acid catabolic process (GO:0042219)2.78485297
144fatty acid elongation (GO:0030497)2.78179900
145response to topologically incorrect protein (GO:0035966)2.78120888
146regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.77525875
147copper ion transport (GO:0006825)2.72372594
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70615317
149positive regulation of regulated secretory pathway (GO:1903307)2.69574313
150aspartate family amino acid catabolic process (GO:0009068)2.65417205
151bundle of His cell to Purkinje myocyte communication (GO:0086069)2.65155615
152endoplasmic reticulum organization (GO:0007029)2.65130580
153negative regulation of receptor-mediated endocytosis (GO:0048261)2.63465809
154coenzyme catabolic process (GO:0009109)2.62048584
155ER overload response (GO:0006983)2.61561649
156regulation of cellular extravasation (GO:0002691)2.59281923
157establishment of protein localization to Golgi (GO:0072600)2.55813665
158regulation of apoptotic process involved in morphogenesis (GO:1902337)2.54763637
159peroxisome fission (GO:0016559)2.51583617
160retrograde transport, vesicle recycling within Golgi (GO:0000301)2.50515613
161fatty acid oxidation (GO:0019395)2.47903421
162pattern specification involved in kidney development (GO:0061004)2.46409038
163cellular response to hydrogen peroxide (GO:0070301)2.45444323
164protein localization to Golgi apparatus (GO:0034067)2.45023414
165biotin metabolic process (GO:0006768)2.44660441
166lipid oxidation (GO:0034440)2.42694233
167negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.41985901
168amino-acid betaine metabolic process (GO:0006577)2.41969700
169germ cell migration (GO:0008354)2.41713970
170regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.40422761
171fatty acid catabolic process (GO:0009062)2.39161046
172cardiac muscle cell proliferation (GO:0060038)2.38359353
173secretion by tissue (GO:0032941)2.36061954
174lung cell differentiation (GO:0060479)2.32420438
175synaptic vesicle docking involved in exocytosis (GO:0016081)2.32225868
176negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.31064601
177regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29164106
178erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.28040815
179L-phenylalanine catabolic process (GO:0006559)2.28040815
180pyrimidine-containing compound transmembrane transport (GO:0072531)2.27873567
181sulfur amino acid catabolic process (GO:0000098)2.27670698
182urinary tract smooth muscle contraction (GO:0014848)13.5755814
183peristalsis (GO:0030432)12.3444129
184* detection of chemical stimulus involved in sensory perception of taste (GO:0050912)12.1815966
185* detection of chemical stimulus involved in sensory perception (GO:0050907)10.4854433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse4.08692498
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.67119652
3* ESR1_20079471_ChIP-ChIP_T-47D_Human3.15817385
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.03284869
5* ELF5_23300383_ChIP-Seq_T47D_Human2.91368089
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.77886458
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.77012309
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.56615154
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.51808856
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.49739615
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46288436
12FOXO3_23340844_ChIP-Seq_DLD1_Human2.37246520
13CLOCK_20551151_ChIP-Seq_293T_Human2.36733551
14SOX2_27498859_Chip-Seq_STOMACH_Mouse2.28723436
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25361048
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.19141771
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05474516
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01244604
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.96114925
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92958756
21ZNF263_19887448_ChIP-Seq_K562_Human1.87046648
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80919516
23AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.80435643
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79285132
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72891950
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.71902439
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.71536800
28KDM5A_27292631_Chip-Seq_BREAST_Human1.67801446
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67453284
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66147463
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.65568422
32FOXA2_19822575_ChIP-Seq_HepG2_Human1.64185729
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.62322712
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60885393
35BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.60525955
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60479731
37NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.58924046
38SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.58911296
39SOX2_20726797_ChIP-Seq_SW620_Human1.57865233
40ESR1_15608294_ChIP-ChIP_MCF-7_Human1.57741790
41P68_20966046_ChIP-Seq_HELA_Human1.56750231
42RACK7_27058665_Chip-Seq_MCF-7_Human1.54802057
43VDR_21846776_ChIP-Seq_THP-1_Human1.53791195
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51242911
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50951410
46TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50342273
47* AR_21909140_ChIP-Seq_LNCAP_Human1.49935939
48CREB1_26743006_Chip-Seq_LNCaP_Human1.49437387
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49027668
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46454771
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.46255025
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45069973
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44529912
54MYC_22102868_ChIP-Seq_BL_Human1.44455831
55ELK4_26923725_Chip-Seq_MESODERM_Mouse1.43469663
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43284270
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43088403
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40258308
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39253630
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39171912
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37204995
62GATA6_25053715_ChIP-Seq_YYC3_Human1.34541692
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34407660
64* SMC4_20622854_ChIP-Seq_HELA_Human1.34155922
65KLF5_25053715_ChIP-Seq_YYC3_Human1.32909021
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.31126221
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31086274
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31045857
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.30764131
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30478558
71KDM2B_26808549_Chip-Seq_DND41_Human1.29538345
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29046321
73* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27198226
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26457506
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25385997
76CBP_20019798_ChIP-Seq_JUKART_Human1.25385997
77LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23917972
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.23201451
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22397674
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22287906
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20815883
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20343841
83TCF7_22412390_ChIP-Seq_EML_Mouse1.20160528
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19837389
85GATA1_22025678_ChIP-Seq_K562_Human1.19831464
86AHR_22903824_ChIP-Seq_MCF-7_Human1.19442701
87KDM2B_26808549_Chip-Seq_K562_Human1.19291295
88CTCF_27219007_Chip-Seq_Bcells_Human1.18038450
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17549832
90ATF3_27146783_Chip-Seq_COLON_Human1.17410701
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16362853
92* GATA3_24758297_ChIP-Seq_MCF-7_Human1.15153688
93RXR_22108803_ChIP-Seq_LS180_Human1.14962322
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.14625168
95FOXM1_23109430_ChIP-Seq_U2OS_Human1.13689768
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13295674
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11730889
98FLI1_21867929_ChIP-Seq_CD8_Mouse1.11544623
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10794654
100SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10421241
101GATA4_25053715_ChIP-Seq_YYC3_Human1.10217789
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09738805
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09707141
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09661277
105XRN2_22483619_ChIP-Seq_HELA_Human1.09270797
106ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08677574
107FOXA1_25552417_ChIP-Seq_VCAP_Human1.08672447
108* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07828657
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.06900960
110LXR_22292898_ChIP-Seq_THP-1_Human1.06875269
111MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06313708
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.05624976
113RARB_24833708_ChIP-Seq_LIVER_Mouse1.04787866
114KDM2B_26808549_Chip-Seq_REH_Human1.04408085
115SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04155648
116FOXP1_21924763_ChIP-Seq_HESCs_Human1.04023494
117FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01973255
118ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01522851
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01146914
120CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00796752
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00198569
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99993474
123BCOR_27268052_Chip-Seq_Bcells_Human0.99533488
124CHD1_26751641_Chip-Seq_LNCaP_Human0.99031488
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98109261
126CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97693802
127ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97585259
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97441535
129MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97191710
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95940220
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94699599
132TP63_22573176_ChIP-Seq_HFKS_Human0.94126801
133KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93971920
134ETS1_21867929_ChIP-Seq_TH2_Mouse0.93328738
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93302903
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.92947052
137TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92672003
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92442765
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.92031023
140JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.91832314
141EP300_21415370_ChIP-Seq_HL-1_Mouse0.91701584
142* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91144263
143KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91031226
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90921910
145SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.90440171
146GABP_19822575_ChIP-Seq_HepG2_Human0.90115909
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89666386
148P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89089143
149EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88931773
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87997736
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87842478
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87842478
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85635654
154TP63_23658742_ChIP-Seq_EP156T_Human0.85119075
155RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83761542
156EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83761542
157GATA3_21867929_ChIP-Seq_TH1_Mouse0.83426543
158ZNF274_21170338_ChIP-Seq_K562_Hela0.83125522
159CDX2_22108803_ChIP-Seq_LS180_Human0.82564639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland7.67839979
2MP0010030_abnormal_orbit_morphology5.45866442
3MP0005248_abnormal_Harderian_gland3.92352500
4MP0005083_abnormal_biliary_tract3.90602106
5MP0009780_abnormal_chondrocyte_physiolo3.49456054
6MP0002009_preneoplasia3.43657145
7MP0003045_fibrosis3.38017905
8MP0000613_abnormal_salivary_gland3.33250019
9MP0005220_abnormal_exocrine_pancreas3.19480563
10MP0010234_abnormal_vibrissa_follicle2.92646100
11MP0005501_abnormal_skin_physiology2.82716155
12MP0001881_abnormal_mammary_gland2.67924211
13MP0005623_abnormal_meninges_morphology2.63985963
14MP0002896_abnormal_bone_mineralization2.59048684
15MP0004264_abnormal_extraembryonic_tissu2.57937754
16MP0001666_abnormal_nutrient_absorption2.29911909
17MP0009764_decreased_sensitivity_to2.27755714
18MP0003183_abnormal_peptide_metabolism2.24608075
19MP0004381_abnormal_hair_follicle2.24393490
20MP0005646_abnormal_pituitary_gland2.23732393
21MP0005332_abnormal_amino_acid2.23377940
22MP0005365_abnormal_bile_salt2.21631701
23MP0005085_abnormal_gallbladder_physiolo2.11138666
24MP0002254_reproductive_system_inflammat2.06929912
25MP0004019_abnormal_vitamin_homeostasis2.04466176
26MP0000537_abnormal_urethra_morphology2.02545810
27MP0000377_abnormal_hair_follicle2.01623955
28MP0003690_abnormal_glial_cell1.93213821
29MP0000427_abnormal_hair_cycle1.84735161
30MP0003806_abnormal_nucleotide_metabolis1.66267120
31MP0002168_other_aberrant_phenotype1.56432953
32MP0001533_abnormal_skeleton_physiology1.55927731
33MP0001873_stomach_inflammation1.55215913
34MP0000566_synostosis1.54583867
35MP0001216_abnormal_epidermal_layer1.54167632
36MP0000579_abnormal_nail_morphology1.53380168
37MP0000747_muscle_weakness1.48439971
38MP0009384_cardiac_valve_regurgitation1.39295992
39MP0004130_abnormal_muscle_cell1.38007975
40MP0004510_myositis1.36719261
41MP0003878_abnormal_ear_physiology1.36612840
42MP0005377_hearing/vestibular/ear_phenot1.36612840
43MP0000858_altered_metastatic_potential1.32971873
44MP0004233_abnormal_muscle_weight1.31681782
45MP0005379_endocrine/exocrine_gland_phen1.31302580
46MP0000383_abnormal_hair_follicle1.31144112
47MP0009765_abnormal_xenobiotic_induced1.26305083
48MP0003633_abnormal_nervous_system1.24844941
49MP0005360_urolithiasis1.23655204
50MP0008875_abnormal_xenobiotic_pharmacok1.23573952
51MP0003866_abnormal_defecation1.23103579
52MP0001299_abnormal_eye_distance/1.18886177
53MP0003566_abnormal_cell_adhesion1.17851731
54MP0004272_abnormal_basement_membrane1.16716934
55MP0002139_abnormal_hepatobiliary_system1.14878644
56MP0003936_abnormal_reproductive_system1.12191036
57MP0001664_abnormal_digestion1.10904351
58MP0010329_abnormal_lipoprotein_level1.09950008
59MP0002166_altered_tumor_susceptibility1.08276751
60MP0010771_integument_phenotype1.07372414
61MP0003632_abnormal_nervous_system1.06867287
62MP0003300_gastrointestinal_ulcer1.06840780
63MP0005197_abnormal_uvea_morphology1.05931700
64MP0002118_abnormal_lipid_homeostasis1.05224125
65MP0003631_nervous_system_phenotype1.04394549
66MP0005075_abnormal_melanosome_morpholog1.04381675
67MP0000490_abnormal_crypts_of1.04040547
68MP0008789_abnormal_olfactory_epithelium1.02764195
69MP0005058_abnormal_lysosome_morphology1.02562320
70MP0001944_abnormal_pancreas_morphology1.02091485
71MP0003315_abnormal_perineum_morphology1.00129328
72MP0000647_abnormal_sebaceous_gland1.00082916
73MP0002796_impaired_skin_barrier0.98650742
74MP0009931_abnormal_skin_appearance0.98351404
75MP0005275_abnormal_skin_tensile0.95414460
76MP0001727_abnormal_embryo_implantation0.94020572
77MP0002115_abnormal_skeleton_extremities0.92459718
78MP0000627_abnormal_mammary_gland0.92320103
79MP0005167_abnormal_blood-brain_barrier0.91894360
80MP0010386_abnormal_urinary_bladder0.89608266
81MP0005319_abnormal_enzyme/_coenzyme0.88823192
82MP0003329_amyloid_beta_deposits0.88179382
83MP0009643_abnormal_urine_homeostasis0.87453288
84MP0004270_analgesia0.87145240
85MP0001919_abnormal_reproductive_system0.86997123
86MP0003705_abnormal_hypodermis_morpholog0.86990228
87MP0002282_abnormal_trachea_morphology0.85247300
88MP0003724_increased_susceptibility_to0.83159839
89MP0005187_abnormal_penis_morphology0.81642701
90MP0004185_abnormal_adipocyte_glucose0.81300865
91MP0005395_other_phenotype0.80380305
92MP0005584_abnormal_enzyme/coenzyme_acti0.80067320
93MP0002098_abnormal_vibrissa_morphology0.79123001
94MP0003075_altered_response_to0.79121358
95MP0005636_abnormal_mineral_homeostasis0.77736491
96MP0004782_abnormal_surfactant_physiolog0.77136476
97MP0000920_abnormal_myelination0.76524678
98MP0004859_abnormal_synaptic_plasticity0.76431395
99MP0004145_abnormal_muscle_electrophysio0.75458560
100MP0000609_abnormal_liver_physiology0.75093615
101MP0008770_decreased_survivor_rate0.75076686
102MP0000470_abnormal_stomach_morphology0.74593998
103MP0002277_abnormal_respiratory_mucosa0.74366393
104MP0000367_abnormal_coat/_hair0.73409143
105MP0000762_abnormal_tongue_morphology0.73272246
106MP0002006_tumorigenesis0.72121738
107MP0005390_skeleton_phenotype0.72014490
108MP0008438_abnormal_cutaneous_collagen0.71535373
109MP0010678_abnormal_skin_adnexa0.70611901
110MP0003453_abnormal_keratinocyte_physiol0.70474650
111MP0000681_abnormal_thyroid_gland0.70028254
112MP0000163_abnormal_cartilage_morphology0.69844804
113MP0003795_abnormal_bone_structure0.69624376
114MP0005310_abnormal_salivary_gland0.69142678
115MP0003191_abnormal_cellular_cholesterol0.68651072
116MP0001765_abnormal_ion_homeostasis0.68197551
117MP0004858_abnormal_nervous_system0.67890807
118MP0001243_abnormal_dermal_layer0.65791200
119MP0003123_paternal_imprinting0.62148550
120MP0003763_abnormal_thymus_physiology0.61735950
121MP0001348_abnormal_lacrimal_gland0.59421280
122MP0005381_digestive/alimentary_phenotyp0.56874726
123MP0002078_abnormal_glucose_homeostasis0.56514288
124MP0002060_abnormal_skin_morphology0.56512064
125MP0001663_abnormal_digestive_system0.56323705
126MP0005666_abnormal_adipose_tissue0.56227146
127MP0003656_abnormal_erythrocyte_physiolo0.55993953
128MP0002136_abnormal_kidney_physiology0.55828706
129MP0002332_abnormal_exercise_endurance0.55560418
130MP0003879_abnormal_hair_cell0.55450814
131MP0005408_hypopigmentation0.54450566
132MP0001849_ear_inflammation0.54092653
133MP0002113_abnormal_skeleton_development0.54073555
134MP0000604_amyloidosis0.53418597
135MP0002909_abnormal_adrenal_gland0.53313114
136MP0005375_adipose_tissue_phenotype0.53000147
137MP0010630_abnormal_cardiac_muscle0.52726765
138MP0003303_peritoneal_inflammation0.52441884
139MP0000598_abnormal_liver_morphology0.52023314
140MP0000467_abnormal_esophagus_morphology0.51828915
141MP0001756_abnormal_urination0.49705524
142MP0010155_abnormal_intestine_physiology0.45275983
143MP0003938_abnormal_ear_development0.42755373
144MP0002933_joint_inflammation0.41165719
145MP0002653_abnormal_ependyma_morphology0.41066550
146MP0001544_abnormal_cardiovascular_syste0.40890697
147MP0005385_cardiovascular_system_phenoty0.40890697
148MP0002751_abnormal_autonomic_nervous0.39703376
149MP0009672_abnormal_birth_weight0.39612293
150MP0000678_abnormal_parathyroid_gland0.39609519
151MP0005409_darkened_coat_color0.37983965
152MP0002088_abnormal_embryonic_growth/wei0.37696908
153MP0003941_abnormal_skin_development0.35033195
154MP0003693_abnormal_embryo_hatching0.34473849
155MP0003699_abnormal_female_reproductive0.32869710

Predicted human phenotypes

RankGene SetZ-score
1Pili torti (HP:0003777)9.13122844
2Curly hair (HP:0002212)7.43374139
3Tinnitus (HP:0000360)6.56621442
4Fibular aplasia (HP:0002990)6.36393002
5Abnormal hair laboratory examination (HP:0003328)5.80301026
6Mesomelia (HP:0003027)5.14967454
7Short 1st metacarpal (HP:0010034)5.04377958
8Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.04377958
9Sensorimotor neuropathy (HP:0007141)4.84200861
10Abnormality of the phalanges of the 2nd finger (HP:0009541)4.78680906
11Thin bony cortex (HP:0002753)4.74382760
12Septate vagina (HP:0001153)4.64921996
13Cortical dysplasia (HP:0002539)4.63500874
14Congenital ichthyosiform erythroderma (HP:0007431)4.60280603
15Sparse lateral eyebrow (HP:0005338)4.56765349
16Humeroradial synostosis (HP:0003041)4.53167890
17Synostosis involving the elbow (HP:0003938)4.53167890
18Abnormality of the 1st metacarpal (HP:0010009)4.39456495
19Enlarged epiphyses (HP:0010580)4.38331463
20Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.21807237
21Spastic diplegia (HP:0001264)4.17721238
22Abnormality of the proximal phalanges of the hand (HP:0009834)3.88827755
23Distal lower limb muscle weakness (HP:0009053)3.83227701
24Abnormal pupillary function (HP:0007686)3.81463061
25Gout (HP:0001997)3.79883649
26Tongue fasciculations (HP:0001308)3.71334371
27Microretrognathia (HP:0000308)3.67406612
28Abnormality of the 2nd finger (HP:0004100)3.54002327
29Akinesia (HP:0002304)3.53758048
30Radial bowing (HP:0002986)3.51018330
31Exostoses (HP:0100777)3.46233743
32Deformed tarsal bones (HP:0008119)3.45310481
33Tubulointerstitial nephritis (HP:0001970)3.43642052
34Flat capital femoral epiphysis (HP:0003370)3.42995569
35Flattened epiphyses (HP:0003071)3.37508805
36Concave nail (HP:0001598)3.34627305
37Muscle fibrillation (HP:0010546)3.21595637
38Gonadotropin excess (HP:0000837)3.17855988
39Symphalangism affecting the phalanges of the hand (HP:0009773)3.14285462
40Abnormality of the middle phalanges of the toes (HP:0010183)3.13678578
41Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.11356687
42Severe Myopia (HP:0011003)3.07126532
43Right ventricular cardiomyopathy (HP:0011663)3.07055518
442-3 toe syndactyly (HP:0004691)3.06664985
45Fibular hypoplasia (HP:0003038)3.03846624
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.02870211
47Myopathic facies (HP:0002058)3.02189697
48Hypoparathyroidism (HP:0000829)3.01326585
49Hydroxyprolinuria (HP:0003080)2.99105104
50Abnormality of proline metabolism (HP:0010907)2.99105104
51Breast carcinoma (HP:0003002)2.98436960
52Short phalanx of the thumb (HP:0009660)2.97456779
53Increased CSF protein (HP:0002922)2.94290168
54Asymmetry of the thorax (HP:0001555)2.85847700
55Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.85042721
56Bowed forearm bones (HP:0003956)2.84835173
57Bowing of the arm (HP:0006488)2.84835173
58Adactyly (HP:0009776)2.84694332
59Abnormality of the distal phalanges of the toes (HP:0010182)2.84021722
60Hypoplastic ischia (HP:0003175)2.83974790
61Abnormality of the phalanges of the 5th finger (HP:0004213)2.82978541
62Renal salt wasting (HP:0000127)2.81768873
63Short tibia (HP:0005736)2.76311431
64Abnormality of fatty-acid metabolism (HP:0004359)2.73346515
65Germ cell neoplasia (HP:0100728)2.71922714
66Hyporeflexia of lower limbs (HP:0002600)2.71504305
67Abnormality of the intrinsic pathway (HP:0010989)2.71355201
68Anosmia (HP:0000458)2.70046004
69Hamartoma of the eye (HP:0010568)2.68105994
70Flat acetabular roof (HP:0003180)2.68104181
71Conjunctival hamartoma (HP:0100780)2.67748543
72Diminished movement (HP:0002374)2.65625560
73Ankle clonus (HP:0011448)2.63703470
74Short hallux (HP:0010109)2.63212596
75Lymphangioma (HP:0100764)2.62792035
76Enlarged penis (HP:0000040)2.60618283
77Aplasia/Hypoplasia of the fibula (HP:0006492)2.59931392
78Hypoplasia of the pons (HP:0012110)2.59520831
79Narrow nasal bridge (HP:0000446)2.59237636
80Ankyloglossia (HP:0010296)2.58692482
81Diaphragmatic weakness (HP:0009113)2.58202571
82Subcapsular cataract (HP:0000523)2.56417068
83Abnormal tarsal ossification (HP:0008369)2.55516929
84Abnormality of the ischium (HP:0003174)2.54032985
85Aplasia/Hypoplasia of the hallux (HP:0008362)2.53931292
86Abnormality of nail color (HP:0100643)2.53363443
87Abnormality of the common coagulation pathway (HP:0010990)2.52493520
88Short metatarsal (HP:0010743)2.52072727
89Vascular calcification (HP:0004934)2.51008495
90Ulnar claw (HP:0001178)2.50930538
91Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.48947430
92Mucopolysacchariduria (HP:0008155)2.45807418
93Urinary glycosaminoglycan excretion (HP:0003541)2.45807418
94Oligomenorrhea (HP:0000876)2.44794548
95Ketosis (HP:0001946)2.43206148
96Deep venous thrombosis (HP:0002625)2.42986192
97Premature skin wrinkling (HP:0100678)2.42071389
98Testicular neoplasm (HP:0010788)2.42028893
99Testicular atrophy (HP:0000029)2.41910920
100Back pain (HP:0003418)2.41704536
101Cardiovascular calcification (HP:0011915)2.41556318
102Dysostosis multiplex (HP:0000943)2.40720863
103Fasciculations (HP:0002380)2.37663286
104Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.37564857
105Conjugated hyperbilirubinemia (HP:0002908)2.35233085
106Bulbar palsy (HP:0001283)2.34257728
107Epiphyseal stippling (HP:0010655)2.34073338
108Amelogenesis imperfecta (HP:0000705)2.33693093
109Lip pit (HP:0100267)2.31665746
110Partial duplication of the phalanx of hand (HP:0009999)2.31177027
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29214297
112Clumsiness (HP:0002312)2.29125450
113Malnutrition (HP:0004395)2.27114586
114Infantile muscular hypotonia (HP:0008947)2.24808877
115Abnormality of the pons (HP:0007361)2.22468110
116Macroorchidism (HP:0000053)2.22143471
117Aplasia/Hypoplasia of metatarsal bones (HP:0001964)2.21810900
118Abnormality of polysaccharide metabolism (HP:0011012)2.21778682
119Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21778682
120Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21778682
121Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.21040364
122Aplasia/Hypoplasia of the tibia (HP:0005772)2.20712274
123Severe short stature (HP:0003510)2.19081782
124Hypokinesia (HP:0002375)2.18687942
125Partial duplication of thumb phalanx (HP:0009944)2.15906959
126Short humerus (HP:0005792)2.15442161
127Congenital glaucoma (HP:0001087)2.15332961
128Limb-girdle muscle atrophy (HP:0003797)2.14793582
129Fragile skin (HP:0001030)2.12697577
130Generalized hypopigmentation of hair (HP:0011358)2.12163709
131Type I transferrin isoform profile (HP:0003642)2.09783869
132Woolly hair (HP:0002224)2.09518272
133Osteoarthritis (HP:0002758)2.08712252
134Rectal prolapse (HP:0002035)2.08467495
135Adenoma sebaceum (HP:0009720)2.07411027
136Angiofibromas (HP:0010615)2.07411027
137Blepharitis (HP:0000498)2.04272644
138Hyperglycinuria (HP:0003108)2.04012128
139Ketoacidosis (HP:0001993)2.03953382
140Micronodular cirrhosis (HP:0001413)2.03728654
141Deep philtrum (HP:0002002)2.02994020
142Protuberant abdomen (HP:0001538)2.01105612
143Hyperglycinemia (HP:0002154)2.00618077
144Abdominal distention (HP:0003270)1.99679231
145Stridor (HP:0010307)1.99503170
146Bell-shaped thorax (HP:0001591)1.99438461
147Femoral bowing (HP:0002980)1.98193431
148Abnormality of the phalanges of the hallux (HP:0010057)1.95841442
149Bilateral sensorineural hearing impairment (HP:0008619)1.93725482
150Camptodactyly of toe (HP:0001836)1.93109828
151Abnormal epiphyseal ossification (HP:0010656)1.92573902
152Biliary tract neoplasm (HP:0100574)1.92524420
153Hand muscle atrophy (HP:0009130)1.91838334
154Abnormality of oral frenula (HP:0000190)1.90366396
155Blue sclerae (HP:0000592)1.90219302
156Wide cranial sutures (HP:0010537)1.87168044
157Hypoplasia of the iris (HP:0007676)1.87156270
158Visceral angiomatosis (HP:0100761)1.86750701
159Advanced eruption of teeth (HP:0006288)1.86621881
160Abnormality of glycine metabolism (HP:0010895)1.86068126
161Abnormality of serine family amino acid metabolism (HP:0010894)1.86068126
162Pulmonary artery stenosis (HP:0004415)1.85596966
163Rimmed vacuoles (HP:0003805)1.85198278
164Cardiomegaly (HP:0001640)1.84120108
165Aplasia/hypoplasia of the humerus (HP:0006507)1.83238175
166Atrophic scars (HP:0001075)1.79225958
167Brushfield spots (HP:0001088)1.79043732
168Polar cataract (HP:0010696)1.79010249
169Bone cyst (HP:0012062)1.78623960
170Cervical subluxation (HP:0003308)1.77850892
171Renal tubular acidosis (HP:0001947)1.75527971
172Rhizomelia (HP:0008905)1.74989460
173Subacute progressive viral hepatitis (HP:0006572)1.73559545
174Cerebral inclusion bodies (HP:0100314)1.72240961
175Buphthalmos (HP:0000557)1.70069126
176Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68288358
177Calf muscle hypertrophy (HP:0008981)1.63995853
178Turricephaly (HP:0000262)1.62688405
179Visual hallucinations (HP:0002367)1.62137434
180Hypoplasia of dental enamel (HP:0006297)1.61584902
181Axonal loss (HP:0003447)1.58161121
182Hyperphosphatemia (HP:0002905)1.56990028
183Urethral obstruction (HP:0000796)1.56529027
184Broad hallux (HP:0010055)1.56048495
185Abolished electroretinogram (ERG) (HP:0000550)1.54000010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.91855425
2EPHA25.73746697
3LATS13.92398625
4TESK23.83484542
5ERN13.50353817
6STK393.32074758
7VRK23.13155292
8PDK32.98893629
9PDK42.98893629
10TESK12.95283596
11IRAK32.90471050
12GRK52.87848541
13FER2.85505369
14MST42.37838245
15TNK22.29914545
16WNK42.23995882
17EEF2K2.13444986
18EIF2AK12.04810349
19MAP2K42.02743122
20TAOK31.99623273
21PIK3CA1.96520776
22MAP3K91.86372250
23TRIB31.82714215
24MAP3K41.79669017
25PDK21.77846871
26EPHB11.76844751
27ILK1.75156003
28PKN21.56110958
29SMG11.55671167
30FRK1.53827967
31NME21.49685463
32MAP3K21.48567256
33PTK61.41876293
34EPHA31.31404920
35ZAP701.30914703
36RET1.30433643
37PRKCI1.26052412
38LIMK11.24129339
39ICK1.20762404
40HIPK21.20220427
41MST1R1.16579423
42NEK61.15042122
43MAP3K71.07826444
44MAP2K61.06333061
45CDK81.06254478
46MAP2K71.05281675
47WEE11.03393501
48MET1.02965315
49RPS6KB21.00526317
50NTRK10.99554946
51RIPK10.96773456
52LATS20.94237255
53WNK10.93637774
54CDK70.88715300
55BMX0.87553627
56MAP3K130.86418978
57MAPK150.84262330
58PAK40.83268315
59CAMKK10.83081455
60STK380.82342859
61INSRR0.81548690
62UHMK10.76989370
63LRRK20.75739794
64EIF2AK30.75697712
65NTRK30.75439561
66STK240.74543231
67SIK10.71824793
68DDR20.71544047
69MAP2K20.70713011
70PAK30.69730705
71IRAK10.69247310
72MAPKAPK50.64537173
73PDGFRA0.64213739
74TSSK60.63819004
75SCYL20.63090504
76PTK20.61253456
77STK30.60005276
78KSR20.59068868
79TRIM280.57510575
80IRAK20.57152278
81FGFR40.55800416
82TBK10.55660447
83PDGFRB0.53304843
84IRAK40.51054686
85NUAK10.50924415
86MAP2K30.50477006
87DMPK0.49346307
88JAK20.48593728
89CAMK1D0.48112448
90PRKD10.47666022
91CDK50.47361447
92CAMK1G0.47056651
93AURKB0.46548288
94MAP3K120.45976869
95PDPK10.45968649
96TAOK10.45772423
97TRPM70.45239785
98ERBB20.45022100
99OXSR10.44201817
100GRK60.44024073
101TTN0.43555698
102DAPK20.42250704
103MAPK120.42170734
104PDK10.41822008
105MAPKAPK20.41760557
106ALK0.40880613
107MTOR0.40563507
108FGFR20.40449833
109TGFBR20.40308878
110MAP3K30.38675540
111FLT30.38362831
112TAF10.38124398
113JAK10.37950513
114PAK20.37894722
115CDK120.37428423
116RPS6KA20.37112120
117MAPKAPK30.35961729
118FGFR30.35646729
119CAMK2G0.34638607
120CAMK2B0.34583933
121RPS6KB10.33778437
122MINK10.32003030
123LMTK20.31658922
124CSNK1E0.31536617
125FYN0.31456343
126FGR0.31077248
127PAK60.31059271
128ARAF0.30576538
129BCR0.30506378
130CDK60.29902250
131MATK0.28879415
132MAP3K110.27367081
133VRK10.26139266
134MAP2K10.25068485
135SRC0.23576842
136AKT20.23368059
137TYRO30.22504639
138EPHA40.22428753
139CAMK2D0.21807598
140MAP3K10.20915868
141CSNK1A10.20350759
142INSR0.19379195
143MAP4K10.17999339
144MARK20.17062612
145TLK10.15926510
146PRKCD0.14689730
147MAP3K140.13526067
148MAPK110.13144725
149BMPR20.12868243
150ROCK20.11042902
151PRKD20.10913614
152CAMK10.10575940
153MAPK80.10004862
154YES10.09076082
155STK100.08577926
156MYLK0.08389986
157CDC42BPA0.08236573
158MAP3K80.07579980
159DAPK10.07507694
160GSK3B0.05745962
161CSNK1D0.05331780
162PIK3CG0.04445120
163MAPK100.03997294

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003606.01662631
2Protein export_Homo sapiens_hsa030604.48903864
3Cyanoamino acid metabolism_Homo sapiens_hsa004604.10680342
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.10084609
5Tyrosine metabolism_Homo sapiens_hsa003504.03774829
6Salivary secretion_Homo sapiens_hsa049704.00591639
7Maturity onset diabetes of the young_Homo sapiens_hsa049503.33452091
8Other glycan degradation_Homo sapiens_hsa005113.03530596
9Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.79471312
10Propanoate metabolism_Homo sapiens_hsa006402.74685956
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.62031904
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28964609
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.26098571
14Taste transduction_Homo sapiens_hsa047422.21014002
15Fatty acid biosynthesis_Homo sapiens_hsa000612.10653410
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.05611715
17Nitrogen metabolism_Homo sapiens_hsa009102.03350178
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01319856
19Caffeine metabolism_Homo sapiens_hsa002321.99107307
20Pyruvate metabolism_Homo sapiens_hsa006201.85275562
21Sulfur metabolism_Homo sapiens_hsa009201.83356573
22Fatty acid degradation_Homo sapiens_hsa000711.80513676
23Steroid biosynthesis_Homo sapiens_hsa001001.76922621
24Arginine biosynthesis_Homo sapiens_hsa002201.51786128
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51595814
26Sphingolipid metabolism_Homo sapiens_hsa006001.47706853
27beta-Alanine metabolism_Homo sapiens_hsa004101.45723559
28Glutathione metabolism_Homo sapiens_hsa004801.42577564
29Peroxisome_Homo sapiens_hsa041461.37203994
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36590104
31Sulfur relay system_Homo sapiens_hsa041221.33264627
32Tryptophan metabolism_Homo sapiens_hsa003801.30705568
33Histidine metabolism_Homo sapiens_hsa003401.24549526
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19705925
35Selenocompound metabolism_Homo sapiens_hsa004501.15393534
36N-Glycan biosynthesis_Homo sapiens_hsa005101.15138322
37Fructose and mannose metabolism_Homo sapiens_hsa000511.14054793
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07489737
39Fatty acid metabolism_Homo sapiens_hsa012121.06795686
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04621568
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02334279
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02270534
43VEGF signaling pathway_Homo sapiens_hsa043701.01732112
44Butanoate metabolism_Homo sapiens_hsa006501.01160572
45Collecting duct acid secretion_Homo sapiens_hsa049660.94855500
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94426517
47Bile secretion_Homo sapiens_hsa049760.93893003
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93678160
49Thyroid cancer_Homo sapiens_hsa052160.80033322
50PPAR signaling pathway_Homo sapiens_hsa033200.79208114
51Notch signaling pathway_Homo sapiens_hsa043300.78497280
52Arginine and proline metabolism_Homo sapiens_hsa003300.78024336
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76339463
54Carbon metabolism_Homo sapiens_hsa012000.76017146
55Thyroid hormone synthesis_Homo sapiens_hsa049180.74166927
56Biosynthesis of amino acids_Homo sapiens_hsa012300.72778089
57Insulin resistance_Homo sapiens_hsa049310.69118379
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68206875
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67878042
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.66916167
61Vibrio cholerae infection_Homo sapiens_hsa051100.66867841
62Folate biosynthesis_Homo sapiens_hsa007900.66413298
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66282576
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64919961
65Estrogen signaling pathway_Homo sapiens_hsa049150.64517483
66Insulin secretion_Homo sapiens_hsa049110.63986679
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62878149
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62585221
69Gastric acid secretion_Homo sapiens_hsa049710.60124114
70Glycerolipid metabolism_Homo sapiens_hsa005610.59865267
71Vitamin digestion and absorption_Homo sapiens_hsa049770.58067676
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57490857
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57186799
74Pentose phosphate pathway_Homo sapiens_hsa000300.56791427
75Long-term potentiation_Homo sapiens_hsa047200.56751265
76Pancreatic secretion_Homo sapiens_hsa049720.56453874
77Endometrial cancer_Homo sapiens_hsa052130.55676259
78Dopaminergic synapse_Homo sapiens_hsa047280.52519679
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51827154
80Lysine degradation_Homo sapiens_hsa003100.51581839
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50943400
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48832986
83Pancreatic cancer_Homo sapiens_hsa052120.46503154
84Cholinergic synapse_Homo sapiens_hsa047250.45931412
85Olfactory transduction_Homo sapiens_hsa047400.44611293
86Bladder cancer_Homo sapiens_hsa052190.44439714
87Type II diabetes mellitus_Homo sapiens_hsa049300.44130917
88Renin secretion_Homo sapiens_hsa049240.43383639
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43383308
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43162339
91Chemical carcinogenesis_Homo sapiens_hsa052040.42073382
92Glucagon signaling pathway_Homo sapiens_hsa049220.41842742
93GABAergic synapse_Homo sapiens_hsa047270.41484191
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41252138
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40088320
96Endocytosis_Homo sapiens_hsa041440.39710890
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39263012
98Lysosome_Homo sapiens_hsa041420.38882253
99Prostate cancer_Homo sapiens_hsa052150.38669256
100Amphetamine addiction_Homo sapiens_hsa050310.38086575
101Synaptic vesicle cycle_Homo sapiens_hsa047210.37625256
102Hepatitis C_Homo sapiens_hsa051600.37521768
103Tight junction_Homo sapiens_hsa045300.37322439
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37267517
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36933169
106mTOR signaling pathway_Homo sapiens_hsa041500.36556433
107ErbB signaling pathway_Homo sapiens_hsa040120.36445002
108Acute myeloid leukemia_Homo sapiens_hsa052210.35968144
109Non-small cell lung cancer_Homo sapiens_hsa052230.35871800
110Ovarian steroidogenesis_Homo sapiens_hsa049130.35227900
111Prolactin signaling pathway_Homo sapiens_hsa049170.34992290
112Complement and coagulation cascades_Homo sapiens_hsa046100.34570662
113Cocaine addiction_Homo sapiens_hsa050300.34136112
114Insulin signaling pathway_Homo sapiens_hsa049100.33903892
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33546378
116GnRH signaling pathway_Homo sapiens_hsa049120.33242287
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.31508713
118Small cell lung cancer_Homo sapiens_hsa052220.30520818
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.30319961
120Galactose metabolism_Homo sapiens_hsa000520.28755894
121Fatty acid elongation_Homo sapiens_hsa000620.28221097
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27565067
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26393171
124African trypanosomiasis_Homo sapiens_hsa051430.25934699
125Circadian entrainment_Homo sapiens_hsa047130.25873487
126Pertussis_Homo sapiens_hsa051330.25107187
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.25037341
128ABC transporters_Homo sapiens_hsa020100.24779422
129cAMP signaling pathway_Homo sapiens_hsa040240.24220669
130AMPK signaling pathway_Homo sapiens_hsa041520.24103073
131Amoebiasis_Homo sapiens_hsa051460.24037913
132Glutamatergic synapse_Homo sapiens_hsa047240.24020040
133Proteoglycans in cancer_Homo sapiens_hsa052050.23332537
134Metabolic pathways_Homo sapiens_hsa011000.22688870
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22439181
136Chronic myeloid leukemia_Homo sapiens_hsa052200.22319953
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.20438629
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18245266
139Melanogenesis_Homo sapiens_hsa049160.18175515
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.14231480
141Base excision repair_Homo sapiens_hsa034100.13861931
142Calcium signaling pathway_Homo sapiens_hsa040200.13189119
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12620480
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.12594066
145p53 signaling pathway_Homo sapiens_hsa041150.12286950
146MicroRNAs in cancer_Homo sapiens_hsa052060.12024470
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11525136
148Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09376712
149Hepatitis B_Homo sapiens_hsa051610.05195641

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