PIP4K2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.25767955
2central nervous system myelination (GO:0022010)8.25767955
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76111271
4hepatocyte apoptotic process (GO:0097284)4.70336699
5ensheathment of neurons (GO:0007272)4.43117811
6axon ensheathment (GO:0008366)4.43117811
7myelination (GO:0042552)4.40292654
8L-amino acid import (GO:0043092)4.38426700
9response to interleukin-15 (GO:0070672)4.25014751
10cellular response to interleukin-15 (GO:0071350)4.23864638
11positive T cell selection (GO:0043368)4.07299739
12myelin maintenance (GO:0043217)4.03588594
13positive regulation of granulocyte differentiation (GO:0030854)3.99920055
14regulation of gamma-delta T cell differentiation (GO:0045586)3.81922419
15positive thymic T cell selection (GO:0045059)3.80292826
16DNA deamination (GO:0045006)3.72293018
17response to methylmercury (GO:0051597)3.68445746
18regulation of gamma-delta T cell activation (GO:0046643)3.68389125
19long-chain fatty acid biosynthetic process (GO:0042759)3.66478293
20positive regulation of alpha-beta T cell proliferation (GO:0046641)3.66364677
21thrombin receptor signaling pathway (GO:0070493)3.62414175
22regulation of alpha-beta T cell proliferation (GO:0046640)3.53337671
23regulation of regulatory T cell differentiation (GO:0045589)3.52078524
24T cell migration (GO:0072678)3.46379129
25regulation of platelet aggregation (GO:0090330)3.45856765
26negative regulation of neurotransmitter transport (GO:0051589)3.45624630
27cytidine metabolic process (GO:0046087)3.45372204
28cytidine catabolic process (GO:0006216)3.45372204
29cytidine deamination (GO:0009972)3.45372204
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.43843489
31positive regulation of B cell differentiation (GO:0045579)3.43557311
32fatty acid elongation (GO:0030497)3.38579549
33nerve growth factor signaling pathway (GO:0038180)3.35363658
34adenosine receptor signaling pathway (GO:0001973)3.33639633
35antigen processing and presentation of endogenous antigen (GO:0019883)3.33196711
36negative regulation of T-helper cell differentiation (GO:0045623)3.30439258
37negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.30439258
38regulation of B cell differentiation (GO:0045577)3.30418329
39negative regulation of neurotransmitter secretion (GO:0046929)3.30328700
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30328494
41negative regulation of cell killing (GO:0031342)3.30328494
42negative regulation of T cell mediated immunity (GO:0002710)3.29450944
43mast cell activation (GO:0045576)3.28702102
44dendritic cell migration (GO:0036336)3.26556221
45T cell selection (GO:0045058)3.24896807
46import into cell (GO:0098657)3.23620800
47regulation of B cell receptor signaling pathway (GO:0050855)3.23152504
48protein neddylation (GO:0045116)3.20868639
49neutrophil activation involved in immune response (GO:0002283)3.19648931
50negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.17187683
51synaptic vesicle maturation (GO:0016188)3.16340532
52regulation of T cell receptor signaling pathway (GO:0050856)3.14894735
53activated T cell proliferation (GO:0050798)3.12928375
54interferon-gamma production (GO:0032609)3.10617754
55thymic T cell selection (GO:0045061)3.09772963
56histone mRNA catabolic process (GO:0071044)3.08856360
57negative T cell selection (GO:0043383)3.07501990
58pyrimidine ribonucleoside catabolic process (GO:0046133)3.04999303
59negative regulation of T cell apoptotic process (GO:0070233)3.03889387
60regulation of inositol phosphate biosynthetic process (GO:0010919)3.01539439
61amino acid import (GO:0043090)3.01330746
62negative thymic T cell selection (GO:0045060)3.01159589
63regulation of collateral sprouting (GO:0048670)3.00989385
64negative regulation of lymphocyte mediated immunity (GO:0002707)3.00862084
65cortical actin cytoskeleton organization (GO:0030866)3.00756207
66protein localization to endosome (GO:0036010)2.98893505
67antigen receptor-mediated signaling pathway (GO:0050851)2.98794199
68B cell mediated immunity (GO:0019724)2.98668395
69response to lipoprotein particle (GO:0055094)2.98293567
70dendritic cell chemotaxis (GO:0002407)2.98166000
71negative regulation of B cell proliferation (GO:0030889)2.97814534
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.94475760
73positive regulation of natural killer cell mediated immunity (GO:0002717)2.93680682
74positive regulation of oligodendrocyte differentiation (GO:0048714)2.92692524
75regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92619379
76regulation of natural killer cell mediated immunity (GO:0002715)2.92619379
77negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91666605
78regulation of ARF GTPase activity (GO:0032312)2.90216845
79establishment of mitochondrion localization (GO:0051654)2.88663716
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86438329
81peptidyl-tyrosine autophosphorylation (GO:0038083)2.85408793
82protein K11-linked deubiquitination (GO:0035871)2.83924607
83T cell receptor signaling pathway (GO:0050852)2.82530142
84positive regulation of DNA recombination (GO:0045911)2.82344548
85negative regulation of thymocyte apoptotic process (GO:0070244)2.80473120
86regulation of isotype switching to IgG isotypes (GO:0048302)2.80103532
87antigen processing and presentation via MHC class Ib (GO:0002475)2.79993667
88amyloid precursor protein metabolic process (GO:0042982)2.79528889
89Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79501489
90negative regulation of adaptive immune response (GO:0002820)2.79034279
91positive regulation of macrophage differentiation (GO:0045651)2.76566923
92positive regulation of mast cell activation (GO:0033005)2.76353634
93negative regulation of protein localization to cell surface (GO:2000009)2.76179802
94cortical cytoskeleton organization (GO:0030865)2.75450964
95G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.75335000
96regulation of T cell mediated cytotoxicity (GO:0001914)2.74939950
97Golgi to endosome transport (GO:0006895)2.73086025
98positive regulation of isotype switching (GO:0045830)2.72323108
99negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.71698731
100positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.71243482
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71206805
102antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70729263
103adult walking behavior (GO:0007628)2.70656056
104positive regulation of Rap GTPase activity (GO:0032854)2.70560900
105positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69708976
106negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.69685402
107glycine transport (GO:0015816)2.68435466
108negative regulation of leukocyte mediated immunity (GO:0002704)2.68364677
109cellular extravasation (GO:0045123)2.68143207
110glycosylceramide metabolic process (GO:0006677)2.67681684
111regulation of platelet activation (GO:0010543)2.67669017
112regulation of leukocyte mediated cytotoxicity (GO:0001910)2.67183116
113creatine metabolic process (GO:0006600)2.67178562
114B cell receptor signaling pathway (GO:0050853)2.66868119
115oligodendrocyte differentiation (GO:0048709)2.66846126
116immunoglobulin mediated immune response (GO:0016064)2.65920213
117mast cell degranulation (GO:0043303)2.65192068
118mast cell activation involved in immune response (GO:0002279)2.65192068
119positive regulation of immunoglobulin mediated immune response (GO:0002891)2.63466797
120positive regulation of B cell mediated immunity (GO:0002714)2.63466797
121G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.63408144
122positive regulation of T cell mediated cytotoxicity (GO:0001916)2.62851106
123neutrophil activation (GO:0042119)2.62462480
124neurotransmitter uptake (GO:0001504)2.60794458
125negative regulation of B cell activation (GO:0050869)2.57870605
126membrane raft organization (GO:0031579)2.55760079
127myeloid cell activation involved in immune response (GO:0002275)2.54996774
128actin nucleation (GO:0045010)2.54892546
129positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.52022397
130regulation of homotypic cell-cell adhesion (GO:0034110)2.51647753
131granulocyte activation (GO:0036230)2.50687177
132regulation of amyloid precursor protein catabolic process (GO:1902991)2.50460514
133regulation of Rap GTPase activity (GO:0032317)2.50319424
134microglial cell activation (GO:0001774)2.50305582
135positive regulation of gliogenesis (GO:0014015)2.49696611
136positive regulation of gamma-delta T cell activation (GO:0046645)2.49652038
137positive regulation of T cell cytokine production (GO:0002726)2.43564657
138positive regulation of interleukin-2 production (GO:0032743)2.43411346
139positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.42981183
140positive regulation by symbiont of host defense response (GO:0052509)2.42543718
141modulation by symbiont of host defense response (GO:0052031)2.42543718
142modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.42543718
143modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.42543718
144positive regulation by organism of defense response of other organism involved in symbiotic interact2.42543718
145modulation by symbiont of host immune response (GO:0052553)2.42543718
146cellular response to nerve growth factor stimulus (GO:1990090)2.41690046
147response to nerve growth factor (GO:1990089)2.41690046
148positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.41215464
149regulation of beta-amyloid formation (GO:1902003)2.40057271
150membrane tubulation (GO:0097320)2.39510108
151regulation of T-helper 2 cell differentiation (GO:0045628)2.39302696
152leukocyte migration involved in inflammatory response (GO:0002523)2.38848496
153positive regulation of glial cell differentiation (GO:0045687)2.38834071
154leukocyte degranulation (GO:0043299)2.38820784
155axon development (GO:0061564)2.38447984
156negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.38095983
157regulation of interferon-beta biosynthetic process (GO:0045357)2.36339548
158tolerance induction (GO:0002507)2.36230094
159neuronal action potential propagation (GO:0019227)2.35969942
160negative regulation of inclusion body assembly (GO:0090084)2.34693352
161positive regulation of macrophage cytokine production (GO:0060907)2.34159671
162negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.31140664
163positive regulation of chemokine secretion (GO:0090197)2.28947023
164cerebral cortex radially oriented cell migration (GO:0021799)2.28297781
165leukocyte aggregation (GO:0070486)2.27735725
166regulation of T cell tolerance induction (GO:0002664)2.26972587
167astrocyte development (GO:0014002)2.26327094
168macrophage activation involved in immune response (GO:0002281)2.25598503
169detection of temperature stimulus involved in sensory perception (GO:0050961)2.25044515
170detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.25044515
171Rac protein signal transduction (GO:0016601)2.24923081
172negative regulation of synaptic transmission, GABAergic (GO:0032229)2.23666314
173regulation of interleukin-2 biosynthetic process (GO:0045076)2.20765357
174positive regulation of pseudopodium assembly (GO:0031274)2.20341620
175regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.20239101
176protein palmitoylation (GO:0018345)2.19663196
177negative regulation of axonogenesis (GO:0050771)2.19490580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.48108011
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22123667
3VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.13586137
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.94680261
5IRF8_27001747_Chip-Seq_BMDM_Mouse2.77056253
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70189876
7GATA1_22025678_ChIP-Seq_K562_Human2.57220063
8* RUNX_20019798_ChIP-Seq_JUKART_Human2.51174645
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49882497
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38518263
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09955027
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.07511576
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06527237
14SCL_19346495_ChIP-Seq_HPC-7_Human2.01803997
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.01511881
16IRF8_22096565_ChIP-ChIP_GC-B_Human1.93245155
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92768216
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92657691
19GATA3_26560356_Chip-Seq_TH2_Human1.91230556
20EZH2_22144423_ChIP-Seq_EOC_Human1.88555235
21NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.86816872
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83000374
23SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78479997
24SPI1_23547873_ChIP-Seq_NB4_Human1.77043737
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74708198
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.68677933
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65928548
28SPI1_23127762_ChIP-Seq_K562_Human1.65474017
29RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.64821882
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64117594
31GBX2_23144817_ChIP-Seq_PC3_Human1.63998324
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59231530
33DROSHA_22980978_ChIP-Seq_HELA_Human1.56781930
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53669018
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52668906
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.51796086
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51790434
38VDR_24787735_ChIP-Seq_THP-1_Human1.49535578
39AR_21572438_ChIP-Seq_LNCaP_Human1.49523404
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49028749
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47518614
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.46456797
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44049722
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43127582
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42881597
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40908871
47GATA1_19941826_ChIP-Seq_K562_Human1.40463690
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39366935
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38242813
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38242813
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.36233757
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.36212506
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34537731
54TAF15_26573619_Chip-Seq_HEK293_Human1.33958593
55MYB_26560356_Chip-Seq_TH2_Human1.33897609
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33160167
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28291798
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26662880
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26110514
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25973931
61* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25730924
62VDR_24763502_ChIP-Seq_THP-1_Human1.25329417
63SALL4_22934838_ChIP-ChIP_CD34+_Human1.24269898
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23783656
65VDR_22108803_ChIP-Seq_LS180_Human1.23257637
66KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23001588
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22911194
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22562462
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.22150978
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21496799
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21480409
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20579449
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20546333
74* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20133404
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19070672
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18811148
77* KDM2B_26808549_Chip-Seq_DND41_Human1.16408722
78* RNF2_27304074_Chip-Seq_ESCs_Mouse1.15855437
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15449180
80SMRT_27268052_Chip-Seq_Bcells_Human1.14741518
81GATA3_26560356_Chip-Seq_TH1_Human1.12476556
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12235430
83* PRDM14_20953172_ChIP-Seq_ESCs_Human1.11771860
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11611977
85GATA3_27048872_Chip-Seq_THYMUS_Human1.10283229
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10281695
87SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09803399
88KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09385713
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09235188
90* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08486971
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08067897
92UTX_26944678_Chip-Seq_JUKART_Human1.07662593
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07252070
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.06780993
95TP53_16413492_ChIP-PET_HCT116_Human1.05642825
96* GATA2_21666600_ChIP-Seq_HMVEC_Human1.04550876
97EZH2_27294783_Chip-Seq_ESCs_Mouse1.03996630
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03571837
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02948893
100* P53_22387025_ChIP-Seq_ESCs_Mouse1.02780389
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01977490
102P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01942305
103PU_27001747_Chip-Seq_BMDM_Mouse1.01840436
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01607519
105VDR_23849224_ChIP-Seq_CD4+_Human1.01342440
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.01311413
107* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00722372
108* GATA2_19941826_ChIP-Seq_K562_Human1.00533239
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00043467
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99737734
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98652233
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97708213
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97520049
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.97508357
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96366378
116* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96031267
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95876501
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95841388
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.95722517
120* MAF_26560356_Chip-Seq_TH1_Human0.95537371
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.95367705
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93797019
123KDM2B_26808549_Chip-Seq_K562_Human0.93649948
124* CMYC_18555785_Chip-Seq_ESCs_Mouse0.93528614
125WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93490396
126FLI1_21867929_ChIP-Seq_TH2_Mouse0.93109221
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93065701
128* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92815751
129AHR_22903824_ChIP-Seq_MCF-7_Human0.91840283
130* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.90806096
131E2F1_18555785_Chip-Seq_ESCs_Mouse0.90598439
132ER_23166858_ChIP-Seq_MCF-7_Human0.90291781
133* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90146369
134FOXO3_23340844_ChIP-Seq_DLD1_Human0.90028338
135MYB_26560356_Chip-Seq_TH1_Human0.89255579
136ELK1_19687146_ChIP-ChIP_HELA_Human0.88779821
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.88541109
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88397146
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.88355244
140* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88340470
141REST_21632747_ChIP-Seq_MESCs_Mouse0.88288840
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87627843
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87610741
144BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87446862
145P300_19829295_ChIP-Seq_ESCs_Human0.86963174
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86600663
147* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.86512566
148* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86052335
149GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85798153
150E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85705922
151STAT3_23295773_ChIP-Seq_U87_Human0.85572852
152* PU1_27457419_Chip-Seq_LIVER_Mouse0.85517813
153* STAT3_18555785_Chip-Seq_ESCs_Mouse0.85334752
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.85152683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.57184478
2MP0003690_abnormal_glial_cell3.24542318
3MP0003880_abnormal_central_pattern3.03170412
4MP0001835_abnormal_antigen_presentation2.84377379
5MP0000372_irregular_coat_pigmentation2.80650279
6MP0006082_CNS_inflammation2.79258268
7MP0004859_abnormal_synaptic_plasticity2.74333301
8MP0005075_abnormal_melanosome_morpholog2.71313030
9MP0003303_peritoneal_inflammation2.41626211
10MP0005671_abnormal_response_to2.36872062
11MP0003950_abnormal_plasma_membrane2.32106023
12MP0004381_abnormal_hair_follicle2.31255963
13MP0004510_myositis2.29096859
14MP0004270_analgesia2.28639513
15MP0001790_abnormal_immune_system2.24853353
16MP0005387_immune_system_phenotype2.24853353
17MP0005000_abnormal_immune_tolerance2.18450303
18MP0005058_abnormal_lysosome_morphology2.17299920
19MP0000685_abnormal_immune_system2.11012561
20MP0003329_amyloid_beta_deposits2.07351732
21MP0002064_seizures2.06746422
22MP0008877_abnormal_DNA_methylation2.00585132
23MP0002148_abnormal_hypersensitivity_rea1.98846697
24MP0002419_abnormal_innate_immunity1.92650157
25MP0001800_abnormal_humoral_immune1.92067716
26MP0001486_abnormal_startle_reflex1.90728871
27MP0002272_abnormal_nervous_system1.87598746
28MP0002723_abnormal_immune_serum1.85193054
29MP0002452_abnormal_antigen_presenting1.81378378
30MP0003787_abnormal_imprinting1.80735016
31MP0003635_abnormal_synaptic_transmissio1.80287023
32MP0003634_abnormal_glial_cell1.77944918
33MP0000604_amyloidosis1.77820247
34MP0005409_darkened_coat_color1.72895624
35MP0005310_abnormal_salivary_gland1.72426930
36MP0005423_abnormal_somatic_nervous1.70144157
37MP0000703_abnormal_thymus_morphology1.69956381
38MP0004742_abnormal_vestibular_system1.68611803
39MP0002420_abnormal_adaptive_immunity1.66597984
40MP0001819_abnormal_immune_cell1.66053918
41MP0003633_abnormal_nervous_system1.63227781
42MP0003172_abnormal_lysosome_physiology1.62938977
43MP0003866_abnormal_defecation1.61505216
44MP0006054_spinal_hemorrhage1.60187010
45MP0001851_eye_inflammation1.59763583
46MP0005025_abnormal_response_to1.57616144
47MP0004885_abnormal_endolymph1.56987825
48MP0009745_abnormal_behavioral_response1.56450567
49MP0003075_altered_response_to1.55852180
50MP0001348_abnormal_lacrimal_gland1.53436757
51MP0008569_lethality_at_weaning1.48938128
52MP0004142_abnormal_muscle_tone1.44419171
53MP0003656_abnormal_erythrocyte_physiolo1.44335870
54MP0005464_abnormal_platelet_physiology1.43604346
55MP0003631_nervous_system_phenotype1.36918794
56MP0001905_abnormal_dopamine_level1.33969630
57MP0002396_abnormal_hematopoietic_system1.33669399
58MP0010155_abnormal_intestine_physiology1.33602086
59MP0009046_muscle_twitch1.33552756
60MP0000716_abnormal_immune_system1.28717386
61MP0003300_gastrointestinal_ulcer1.27821227
62MP0009785_altered_susceptibility_to1.27347554
63MP0002063_abnormal_learning/memory/cond1.25531453
64MP0002095_abnormal_skin_pigmentation1.25506922
65MP0002398_abnormal_bone_marrow1.23886080
66MP0001970_abnormal_pain_threshold1.23526564
67MP0003191_abnormal_cellular_cholesterol1.23501620
68MP0001545_abnormal_hematopoietic_system1.20431742
69MP0005397_hematopoietic_system_phenotyp1.20431742
70MP0002405_respiratory_system_inflammati1.20322969
71MP0002229_neurodegeneration1.19154790
72MP0003436_decreased_susceptibility_to1.16763959
73MP0003632_abnormal_nervous_system1.14333834
74MP0002572_abnormal_emotion/affect_behav1.13460849
75MP0005408_hypopigmentation1.11948650
76MP0000569_abnormal_digit_pigmentation1.10213614
77MP0008057_abnormal_DNA_replication1.09234356
78MP0005171_absent_coat_pigmentation1.07793916
79MP0008260_abnormal_autophagy1.07457776
80MP0003183_abnormal_peptide_metabolism1.07368721
81MP0000465_gastrointestinal_hemorrhage1.07288964
82MP0002166_altered_tumor_susceptibility1.04498878
83MP0002933_joint_inflammation1.03755488
84MP0002734_abnormal_mechanical_nocicepti1.03139127
85MP0004484_altered_response_of1.01026236
86MP0008872_abnormal_physiological_respon1.00460535
87MP0002067_abnormal_sensory_capabilities0.98880084
88MP0001968_abnormal_touch/_nociception0.98651598
89MP0004947_skin_inflammation0.97752743
90MP0008874_decreased_physiological_sensi0.95381228
91MP0009764_decreased_sensitivity_to0.95120334
92MP0001501_abnormal_sleep_pattern0.94046111
93MP0000689_abnormal_spleen_morphology0.92499521
94MP0003828_pulmonary_edema0.92259779
95MP0003724_increased_susceptibility_to0.92230963
96MP0002006_tumorigenesis0.92227164
97MP0008004_abnormal_stomach_pH0.91617918
98MP0005174_abnormal_tail_pigmentation0.91310161
99MP0009763_increased_sensitivity_to0.91211357
100MP0009840_abnormal_foam_cell0.90976854
101MP0003763_abnormal_thymus_physiology0.90315619
102MP0002429_abnormal_blood_cell0.89832295
103MP0002733_abnormal_thermal_nociception0.89224470
104MP0003045_fibrosis0.88978324
105MP0002998_abnormal_bone_remodeling0.88966944
106MP0000778_abnormal_nervous_system0.88686079
107MP0001485_abnormal_pinna_reflex0.88389700
108MP0005167_abnormal_blood-brain_barrier0.87917999
109MP0001533_abnormal_skeleton_physiology0.87340453
110MP0000955_abnormal_spinal_cord0.86466215
111MP0009333_abnormal_splenocyte_physiolog0.86361610
112MP0000371_diluted_coat_color0.85860230
113MP0004147_increased_porphyrin_level0.85025034
114MP0002066_abnormal_motor_capabilities/c0.83313806
115MP0002019_abnormal_tumor_incidence0.82801820
116MP0009765_abnormal_xenobiotic_induced0.82534157
117MP0001853_heart_inflammation0.82492209
118MP0001529_abnormal_vocalization0.82487772
119MP0004883_abnormal_blood_vessel0.81324869
120MP0005623_abnormal_meninges_morphology0.80196694
121MP0002102_abnormal_ear_morphology0.80088344
122MP0002722_abnormal_immune_system0.79369063
123MP0005083_abnormal_biliary_tract0.79100374
124MP0001440_abnormal_grooming_behavior0.78701074
125MP0001845_abnormal_inflammatory_respons0.78375292
126MP0000015_abnormal_ear_pigmentation0.77729379
127MP0006036_abnormal_mitochondrial_physio0.77165897
128MP0002736_abnormal_nociception_after0.77006887
129MP0005166_decreased_susceptibility_to0.76876722
130MP0008873_increased_physiological_sensi0.76364178
131MP0003448_altered_tumor_morphology0.73527784
132MP0002132_abnormal_respiratory_system0.71761935
133MP0005084_abnormal_gallbladder_morpholo0.71257197
134MP0008469_abnormal_protein_level0.69574580
135MP0000343_altered_response_to0.67950964
136MP0000858_altered_metastatic_potential0.67514653
137MP0004808_abnormal_hematopoietic_stem0.66433592
138MP0003806_abnormal_nucleotide_metabolis0.65617284
139MP0003786_premature_aging0.61817627
140MP0003195_calcinosis0.61512467

Predicted human phenotypes

RankGene SetZ-score
1Peripheral hypomyelination (HP:0007182)5.45744613
2Neurofibrillary tangles (HP:0002185)5.33635990
3Prolonged bleeding time (HP:0003010)5.10925324
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.63919231
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.63919231
6Supranuclear gaze palsy (HP:0000605)4.61862590
7Petechiae (HP:0000967)4.18347861
8Epistaxis (HP:0000421)3.94558185
9Cerebral inclusion bodies (HP:0100314)3.92864898
10Onion bulb formation (HP:0003383)3.91175776
11Autoimmune hemolytic anemia (HP:0001890)3.84040600
12Abnormality of T cells (HP:0002843)3.82344103
13Gingival bleeding (HP:0000225)3.79780411
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.68048581
15Axonal loss (HP:0003447)3.64344603
16Abnormality of the corticospinal tract (HP:0002492)3.62613426
17IgG deficiency (HP:0004315)3.56361092
18Abnormal platelet volume (HP:0011876)3.51631935
19Segmental peripheral demyelination/remyelination (HP:0003481)3.47714508
20Increased mean platelet volume (HP:0011877)3.46435453
21Slow saccadic eye movements (HP:0000514)3.43843111
22Recurrent abscess formation (HP:0002722)3.34229289
23Encephalitis (HP:0002383)3.22472212
24Recurrent bacterial skin infections (HP:0005406)3.21839858
25Menorrhagia (HP:0000132)3.20934973
26Insidious onset (HP:0003587)3.17688318
27Termporal pattern (HP:0011008)3.17688318
28Abnormality of eosinophils (HP:0001879)3.14395090
29Abnormality of glycolipid metabolism (HP:0010969)3.11037290
30Abnormality of liposaccharide metabolism (HP:0010968)3.11037290
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.11037290
32Increased IgM level (HP:0003496)3.10756654
33Abnormality of the heme biosynthetic pathway (HP:0010472)3.07523675
34Ankle clonus (HP:0011448)3.07503482
35Spontaneous hematomas (HP:0007420)3.06698058
36Increased cerebral lipofuscin (HP:0011813)3.05957532
37Severe combined immunodeficiency (HP:0004430)3.04359489
38Spastic gait (HP:0002064)3.01392183
39Myokymia (HP:0002411)3.00945643
40Dysmetria (HP:0001310)2.97052802
41Ocular albinism (HP:0001107)2.94532828
42Poikilocytosis (HP:0004447)2.93513587
43Abnormality of the prostate (HP:0008775)2.93012049
44Stomatitis (HP:0010280)2.91252176
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.89166789
46Purpura (HP:0000979)2.89141613
47Eczematoid dermatitis (HP:0000976)2.84710300
48Abnormality of T cell number (HP:0011839)2.83639463
49Recurrent viral infections (HP:0004429)2.83499013
50Visual hallucinations (HP:0002367)2.81913206
51Parakeratosis (HP:0001036)2.80497681
52T lymphocytopenia (HP:0005403)2.80051741
53Abnormal auditory evoked potentials (HP:0006958)2.79137677
54Chest pain (HP:0100749)2.78534311
55Abnormality of T cell physiology (HP:0011840)2.78354225
56Gastrointestinal infarctions (HP:0005244)2.76818293
57Action tremor (HP:0002345)2.72917303
58Arterial thrombosis (HP:0004420)2.72468188
59Pulmonary infiltrates (HP:0002113)2.71119688
60Intention tremor (HP:0002080)2.68705833
61Granulocytopenia (HP:0001913)2.68333696
62Chronic otitis media (HP:0000389)2.67589493
63Recurrent skin infections (HP:0001581)2.66860605
64Orchitis (HP:0100796)2.66714248
65Neuronal loss in central nervous system (HP:0002529)2.66398161
66Iris hypopigmentation (HP:0007730)2.58923946
67Recurrent fungal infections (HP:0002841)2.57990488
68Abnormality of macrophages (HP:0004311)2.57172067
69Loss of speech (HP:0002371)2.56871251
70Hypochromic microcytic anemia (HP:0004840)2.56833795
71Abnormal platelet function (HP:0011869)2.52853722
72Impaired platelet aggregation (HP:0003540)2.52853722
73Dyschromatopsia (HP:0007641)2.51439202
74Joint swelling (HP:0001386)2.45123539
75Cellulitis (HP:0100658)2.44512281
76Scanning speech (HP:0002168)2.42785432
77Combined immunodeficiency (HP:0005387)2.41204381
78Mutism (HP:0002300)2.37649500
79Keratoconjunctivitis (HP:0001096)2.35330321
80Panhypogammaglobulinemia (HP:0003139)2.35142066
81Keratoconjunctivitis sicca (HP:0001097)2.34661546
82Abnormality of B cell number (HP:0010975)2.33114809
83Recurrent bronchitis (HP:0002837)2.32724598
84Hypoproteinemia (HP:0003075)2.31938404
85Elevated erythrocyte sedimentation rate (HP:0003565)2.30085544
86Abnormality of binocular vision (HP:0011514)2.29307795
87Diplopia (HP:0000651)2.29307795
88Focal motor seizures (HP:0011153)2.27870396
89Sensory axonal neuropathy (HP:0003390)2.27548204
90Clumsiness (HP:0002312)2.27466331
91Pustule (HP:0200039)2.27435468
92Cerebral hypomyelination (HP:0006808)2.26776031
93Pulmonary embolism (HP:0002204)2.26053526
94Peripheral demyelination (HP:0011096)2.25087935
95Aplasia/Hypoplasia of the macula (HP:0008059)2.21195931
96Hepatosplenomegaly (HP:0001433)2.20954275
97Disinhibition (HP:0000734)2.20689426
98IgM deficiency (HP:0002850)2.20496179
99Urinary urgency (HP:0000012)2.19629199
100Agammaglobulinemia (HP:0004432)2.19100326
101Cerebral hemorrhage (HP:0001342)2.18968858
102Albinism (HP:0001022)2.18673831
103Apathy (HP:0000741)2.17636521
104Autoimmune thrombocytopenia (HP:0001973)2.17262146
105Stomach cancer (HP:0012126)2.16305233
106Dysostosis multiplex (HP:0000943)2.14575653
107Amaurosis fugax (HP:0100576)2.13053969
108Chronic mucocutaneous candidiasis (HP:0002728)2.11943335
109Recurrent cutaneous fungal infections (HP:0011370)2.11943335
110Lower limb muscle weakness (HP:0007340)2.11014110
111Microcytic anemia (HP:0001935)2.10693236
112Hemoptysis (HP:0002105)2.09548339
113Chronic diarrhea (HP:0002028)2.09259017
114Obstructive lung disease (HP:0006536)2.09096742
115Chronic obstructive pulmonary disease (HP:0006510)2.09096742
116Abnormality of the periventricular white matter (HP:0002518)2.07652679
117Lymphopenia (HP:0001888)2.06993153
118Decreased motor nerve conduction velocity (HP:0003431)2.06803044
119Papilledema (HP:0001085)2.05009211
120Hemiplegia (HP:0002301)2.02970295
121Inflammation of the large intestine (HP:0002037)2.02635920
122Aplasia/Hypoplasia affecting the retina (HP:0008061)2.02534304
123Hypochromic anemia (HP:0001931)2.02481210
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01315309
125Colitis (HP:0002583)2.00981872
126Abnormality of cells of the lymphoid lineage (HP:0012140)2.00969961
127Vasculitis (HP:0002633)1.98911857
128Conjunctival telangiectasia (HP:0000524)1.98158400
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.97549856
130Anorexia (HP:0002039)1.97053983
131Hyperlipoproteinemia (HP:0010980)1.96810851
132Delusions (HP:0000746)1.96717167
133Vertigo (HP:0002321)1.96135994
134Meningitis (HP:0001287)1.96093066
135Foot dorsiflexor weakness (HP:0009027)1.95640671
136Generalized hypopigmentation (HP:0007513)1.95451425
137Focal seizures (HP:0007359)1.95416863
138Urinary incontinence (HP:0000020)1.94929647
139Acanthocytosis (HP:0001927)1.94750153
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.93520512
141IgA deficiency (HP:0002720)1.92974698
142Lymphoma (HP:0002665)1.92515744
143Spastic tetraparesis (HP:0001285)1.92389261
144Postural instability (HP:0002172)1.91663474
145Amyloidosis (HP:0011034)1.91371684
146Mediastinal lymphadenopathy (HP:0100721)1.90947291
147Diminished motivation (HP:0000745)1.90287635
148B lymphocytopenia (HP:0010976)1.89224501
149Myositis (HP:0100614)1.89042678
150Abnormality of saccadic eye movements (HP:0000570)1.87613343
151Thyroiditis (HP:0100646)1.86374005
152Leukocytosis (HP:0001974)1.84636187
153Epileptic encephalopathy (HP:0200134)1.84394972
154Retrobulbar optic neuritis (HP:0100654)1.82550365
155Optic neuritis (HP:0100653)1.82550365
156Metabolic alkalosis (HP:0200114)1.82044077
157Premature skin wrinkling (HP:0100678)1.81876295
158Progressive neurologic deterioration (HP:0002344)1.81498501
159Rapidly progressive (HP:0003678)1.80668767
160Partial duplication of thumb phalanx (HP:0009944)1.80241091
161Systemic lupus erythematosus (HP:0002725)1.79630607
162Eosinophilia (HP:0001880)1.78440382
163Gastrointestinal inflammation (HP:0004386)1.78170972
164Recurrent gram-negative bacterial infections (HP:0005420)1.77245778
165Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77111998
166Hammertoe (HP:0001765)1.75034946
167Arterial tortuosity (HP:0005116)1.74202833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.66402506
2TAOK33.52756943
3EPHB13.27007989
4MAP4K12.74846876
5MAPKAPK52.70048142
6PLK22.58710440
7EIF2AK12.56346098
8OXSR12.53837814
9RIPK42.51166795
10SIK32.50058391
11BLK2.42667400
12PKN12.40723406
13CLK12.35239927
14FRK2.31141872
15TEC2.29187389
16MAP3K132.08789143
17TRIM281.96699299
18WNK11.91161783
19NUAK11.77105579
20ACVR1B1.74537459
21FES1.61051275
22CSF1R1.58665055
23EIF2AK31.57057561
24UHMK11.53770334
25FGR1.48622060
26TXK1.48472952
27IRAK41.45537441
28ITK1.44086559
29CDK191.42548911
30FGFR21.37069712
31MARK31.36803034
32MAP3K141.36162112
33TESK21.36086512
34TGFBR21.33481510
35CAMKK21.30850659
36KSR21.30062711
37SGK4941.29588319
38SGK2231.29588319
39PIK3CG1.28427727
40NTRK11.27513584
41PRKCQ1.21535338
42GRK71.20809431
43CSK1.19006981
44SYK1.18920069
45HCK1.18445432
46PLK31.16932591
47BMPR21.16158903
48STK101.13608869
49TYK21.13555957
50KIT1.05096169
51TBK11.04586321
52PAK61.02902379
53JAK11.01391920
54ROCK21.00958924
55ERBB31.00313483
56LCK0.99943873
57NEK60.96760933
58CAMK2B0.96683258
59GRK50.94791069
60CSNK1A1L0.93698086
61IKBKB0.93374897
62PAK30.93170835
63MAP3K90.92013935
64DMPK0.91341342
65SIK20.89896953
66LIMK10.87119645
67CDK50.86117983
68CAMK1G0.84904312
69PDK10.82055663
70PRKCH0.81959950
71PIM10.81755705
72MARK20.81550503
73FYN0.81230673
74GRK60.81000540
75PTK2B0.80259848
76MST40.79917051
77WNK40.79349718
78PDPK10.77980646
79ZAP700.77919702
80TNIK0.77887292
81TYRO30.75517672
82STK40.73664137
83IKBKE0.72451780
84STK110.71056177
85HIPK20.70574503
86EPHA40.70211020
87MINK10.69305016
88CSNK1G30.69247059
89MAPK70.68584498
90BCR0.68491492
91PDGFRB0.68076767
92RET0.65484574
93MAPK150.64381376
94DAPK10.63917535
95MAPK120.63285985
96BTK0.63186013
97ADRBK10.62745218
98MAP3K120.62094664
99PNCK0.61915589
100MAPKAPK30.61190244
101BMPR1B0.60104387
102CAMK2D0.58911605
103MAP3K20.58839436
104LYN0.58778758
105JAK20.58548058
106MAP2K30.58169108
107MAP4K20.57906195
108ADRBK20.57117415
109RAF10.56397122
110* PRKD10.55611543
111CSNK1G20.55280538
112MAPK130.54310130
113SGK20.54094489
114MAP3K10.52451754
115MOS0.51058050
116ALK0.50843699
117CSNK1G10.50526750
118MAP3K30.50492108
119MAPKAPK20.49631985
120CAMK2G0.49596106
121MATK0.48891095
122CAMKK10.48847753
123BUB10.48500350
124TRPM70.48000424
125BMX0.47857086
126TNK20.47458150
127CAMK2A0.45823712
128JAK30.45699479
129NLK0.45158122
130EIF2AK20.44837562
131IGF1R0.44216362
132NTRK20.43511537
133DYRK1A0.43112935
134ERBB20.43102015
135KSR10.42332507
136GSK3A0.42055732
137PRPF4B0.41763086
138DAPK20.41373275
139MET0.40900598
140EGFR0.38864467
141MYLK0.37112117
142PLK40.36183584
143KDR0.35549767
144YES10.33418759
145FGFR30.32961870
146ABL10.32697582
147BRSK20.31931615
148IRAK10.31010694
149MAP3K50.30856220
150SGK30.28452378
151FER0.27640859
152PAK10.26436918

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.26790522
2Type I diabetes mellitus_Homo sapiens_hsa049401.99859325
3B cell receptor signaling pathway_Homo sapiens_hsa046621.90126984
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81758400
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81158434
6Osteoclast differentiation_Homo sapiens_hsa043801.77330286
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67346507
8Ether lipid metabolism_Homo sapiens_hsa005651.66136093
9Chemokine signaling pathway_Homo sapiens_hsa040621.60684138
10Primary immunodeficiency_Homo sapiens_hsa053401.58339488
11T cell receptor signaling pathway_Homo sapiens_hsa046601.57418583
12Leishmaniasis_Homo sapiens_hsa051401.56817050
13Graft-versus-host disease_Homo sapiens_hsa053321.49564895
14Lysosome_Homo sapiens_hsa041421.39269259
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38896064
16Sphingolipid signaling pathway_Homo sapiens_hsa040711.38094460
17Glutamatergic synapse_Homo sapiens_hsa047241.37097337
18Morphine addiction_Homo sapiens_hsa050321.36790649
19Proteasome_Homo sapiens_hsa030501.34905304
20Viral myocarditis_Homo sapiens_hsa054161.33408182
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32505763
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31409535
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28361459
24Pertussis_Homo sapiens_hsa051331.27334006
25Herpes simplex infection_Homo sapiens_hsa051681.27079435
26Endocytosis_Homo sapiens_hsa041441.25943873
27Legionellosis_Homo sapiens_hsa051341.24304628
28Renal cell carcinoma_Homo sapiens_hsa052111.23930369
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23345074
30Dorso-ventral axis formation_Homo sapiens_hsa043201.23014389
31Allograft rejection_Homo sapiens_hsa053301.22770997
32GABAergic synapse_Homo sapiens_hsa047271.22248300
33Long-term depression_Homo sapiens_hsa047301.21965826
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20924028
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20304441
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18451842
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.14314592
38Olfactory transduction_Homo sapiens_hsa047401.14037988
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13996674
40Salivary secretion_Homo sapiens_hsa049701.13886306
41Salmonella infection_Homo sapiens_hsa051321.13572376
42Gastric acid secretion_Homo sapiens_hsa049711.13080719
43Tuberculosis_Homo sapiens_hsa051521.13046020
44Hematopoietic cell lineage_Homo sapiens_hsa046401.12014528
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11078679
46Circadian entrainment_Homo sapiens_hsa047131.10885321
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09783041
48Platelet activation_Homo sapiens_hsa046111.08575798
49Fatty acid elongation_Homo sapiens_hsa000621.07744826
50Non-small cell lung cancer_Homo sapiens_hsa052231.06400163
51Renin secretion_Homo sapiens_hsa049241.06294044
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05420129
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.04500471
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.04419572
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03955549
56Serotonergic synapse_Homo sapiens_hsa047261.03871083
57Steroid biosynthesis_Homo sapiens_hsa001001.03251207
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02595890
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01974060
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01074139
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.00918901
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00897796
63Autoimmune thyroid disease_Homo sapiens_hsa053200.99268169
64Long-term potentiation_Homo sapiens_hsa047200.99002264
65Rheumatoid arthritis_Homo sapiens_hsa053230.96993579
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96085733
67Cholinergic synapse_Homo sapiens_hsa047250.95621801
68MAPK signaling pathway_Homo sapiens_hsa040100.94400202
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.93885410
70Axon guidance_Homo sapiens_hsa043600.93372982
71Apoptosis_Homo sapiens_hsa042100.92782659
72Cocaine addiction_Homo sapiens_hsa050300.92321839
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92316638
74Shigellosis_Homo sapiens_hsa051310.92141687
75Influenza A_Homo sapiens_hsa051640.89628587
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89046513
77Dopaminergic synapse_Homo sapiens_hsa047280.87640708
78Ras signaling pathway_Homo sapiens_hsa040140.86877925
79Non-homologous end-joining_Homo sapiens_hsa034500.86452195
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86424143
81Toxoplasmosis_Homo sapiens_hsa051450.86365469
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.86177908
83Staphylococcus aureus infection_Homo sapiens_hsa051500.85533384
84Malaria_Homo sapiens_hsa051440.84328921
85* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83551899
86ErbB signaling pathway_Homo sapiens_hsa040120.83534586
87Regulation of autophagy_Homo sapiens_hsa041400.83278868
88Sphingolipid metabolism_Homo sapiens_hsa006000.82720730
89African trypanosomiasis_Homo sapiens_hsa051430.82189760
90Hepatitis B_Homo sapiens_hsa051610.81963575
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80496758
92Measles_Homo sapiens_hsa051620.80283851
93cAMP signaling pathway_Homo sapiens_hsa040240.79705781
94Pancreatic cancer_Homo sapiens_hsa052120.79160036
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78886550
96Oxytocin signaling pathway_Homo sapiens_hsa049210.78691416
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78473739
98Phagosome_Homo sapiens_hsa041450.77526692
99Epstein-Barr virus infection_Homo sapiens_hsa051690.77075598
100Synaptic vesicle cycle_Homo sapiens_hsa047210.76549838
101* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75870152
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74858692
103GnRH signaling pathway_Homo sapiens_hsa049120.74709875
104Choline metabolism in cancer_Homo sapiens_hsa052310.73922363
105Collecting duct acid secretion_Homo sapiens_hsa049660.72944509
106VEGF signaling pathway_Homo sapiens_hsa043700.71781994
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70776737
108Phototransduction_Homo sapiens_hsa047440.67843343
109Prion diseases_Homo sapiens_hsa050200.67808054
110TNF signaling pathway_Homo sapiens_hsa046680.66692657
111Amphetamine addiction_Homo sapiens_hsa050310.66094626
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65104793
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.64760976
114Asthma_Homo sapiens_hsa053100.63976751
115Rap1 signaling pathway_Homo sapiens_hsa040150.62912957
116Antigen processing and presentation_Homo sapiens_hsa046120.60517088
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.60355942
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58573716
119Type II diabetes mellitus_Homo sapiens_hsa049300.58149551
120Glioma_Homo sapiens_hsa052140.58147924
121Homologous recombination_Homo sapiens_hsa034400.57512602
122Gap junction_Homo sapiens_hsa045400.57197881
123Viral carcinogenesis_Homo sapiens_hsa052030.51800674
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51459691
125Oocyte meiosis_Homo sapiens_hsa041140.48076653
126Calcium signaling pathway_Homo sapiens_hsa040200.44712837
127RNA degradation_Homo sapiens_hsa030180.35577273
128Acute myeloid leukemia_Homo sapiens_hsa052210.35293427
129Pancreatic secretion_Homo sapiens_hsa049720.32591200
130Glycerolipid metabolism_Homo sapiens_hsa005610.31951911
131Arachidonic acid metabolism_Homo sapiens_hsa005900.30919005
132FoxO signaling pathway_Homo sapiens_hsa040680.29683771
133Mismatch repair_Homo sapiens_hsa034300.29394428
134Systemic lupus erythematosus_Homo sapiens_hsa053220.29342783
135HTLV-I infection_Homo sapiens_hsa051660.29160974

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