PIP4K2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)6.25163597
2synaptic vesicle maturation (GO:0016188)6.14703537
3regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.57914819
4proline transport (GO:0015824)5.38888877
5daunorubicin metabolic process (GO:0044597)5.24537943
6polyketide metabolic process (GO:0030638)5.24537943
7doxorubicin metabolic process (GO:0044598)5.24537943
8postsynaptic membrane organization (GO:0001941)5.06780033
9locomotory exploration behavior (GO:0035641)4.54360885
10layer formation in cerebral cortex (GO:0021819)4.38548567
11maintenance of protein location in nucleus (GO:0051457)4.28761871
12regulation of mammary gland epithelial cell proliferation (GO:0033599)4.19471209
13cellular potassium ion homeostasis (GO:0030007)4.09886620
14histone H4-K8 acetylation (GO:0043982)4.05852021
15histone H4-K5 acetylation (GO:0043981)4.05852021
16pre-miRNA processing (GO:0031054)4.04524746
17atrial cardiac muscle cell action potential (GO:0086014)4.01211509
18regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00369521
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99972380
20neurotransmitter-gated ion channel clustering (GO:0072578)3.95719354
21regulation of synapse maturation (GO:0090128)3.92755550
22glutamate secretion (GO:0014047)3.91728574
23negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.88806426
24presynaptic membrane assembly (GO:0097105)3.86959988
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.80607202
26negative regulation of telomerase activity (GO:0051974)3.77769962
27histone H4-K12 acetylation (GO:0043983)3.73941471
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67069399
29regulation of response to osmotic stress (GO:0047484)3.60736928
30presynaptic membrane organization (GO:0097090)3.57654826
31negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.56753659
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.55929803
33embryonic retina morphogenesis in camera-type eye (GO:0060059)3.54938670
34somite rostral/caudal axis specification (GO:0032525)3.48570126
35histone H4-K16 acetylation (GO:0043984)3.48412309
36vocalization behavior (GO:0071625)3.46140594
37regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.45369776
38positive regulation of macrophage activation (GO:0043032)3.43783688
39regulation of telomere maintenance via telomerase (GO:0032210)3.43140505
40positive regulation of dendritic spine development (GO:0060999)3.42170581
41protein localization to kinetochore (GO:0034501)3.41880707
42exploration behavior (GO:0035640)3.39420644
43neuron recognition (GO:0008038)3.38352526
44cell migration in hindbrain (GO:0021535)3.37741961
45cell communication involved in cardiac conduction (GO:0086065)3.35520801
46heterochromatin organization (GO:0070828)3.35180399
47positive regulation of synapse maturation (GO:0090129)3.32462107
48dendritic spine morphogenesis (GO:0060997)3.31353586
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28575444
50negative regulation of potassium ion transmembrane transport (GO:1901380)3.25180609
51potassium ion homeostasis (GO:0055075)3.24497914
52axonal fasciculation (GO:0007413)3.23492986
53neuronal ion channel clustering (GO:0045161)3.22323280
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.21808994
55regulation of glutamate receptor signaling pathway (GO:1900449)3.19805210
56mitochondrion distribution (GO:0048311)3.19539947
57negative regulation of epidermis development (GO:0045683)3.19294088
58synaptic vesicle exocytosis (GO:0016079)3.18715951
59positive regulation of histone deacetylation (GO:0031065)3.17817679
60NLS-bearing protein import into nucleus (GO:0006607)3.13878218
61membrane depolarization during action potential (GO:0086010)3.13658360
62cell communication by electrical coupling (GO:0010644)3.12995676
63regulation of MHC class I biosynthetic process (GO:0045343)3.11899175
64muscle organ morphogenesis (GO:0048644)3.11734650
65negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.11662748
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11338691
67aminoglycoside antibiotic metabolic process (GO:0030647)3.08118174
68negative regulation of cell cycle G2/M phase transition (GO:1902750)3.07863691
69response to dietary excess (GO:0002021)3.07840496
70regulation of synapse structural plasticity (GO:0051823)3.06830453
71protein localization to synapse (GO:0035418)3.06240764
72L-amino acid import (GO:0043092)3.04584231
73microtubule nucleation (GO:0007020)3.01246634
74nerve growth factor signaling pathway (GO:0038180)3.00481946
75detection of temperature stimulus (GO:0016048)2.99403953
76regulation of synaptic vesicle exocytosis (GO:2000300)2.98504932
77auditory behavior (GO:0031223)2.97862533
78positive regulation of axon extension (GO:0045773)2.97423099
79regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96546512
80neuroblast proliferation (GO:0007405)2.95765704
81negative regulation of cAMP-mediated signaling (GO:0043951)2.95538537
82establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94869326
83mitochondrion transport along microtubule (GO:0047497)2.94869326
84negative regulation of cell size (GO:0045792)2.92311609
85mechanosensory behavior (GO:0007638)2.91576935
86neurotransmitter secretion (GO:0007269)2.91562142
87synaptic transmission, glutamatergic (GO:0035249)2.91510457
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91063743
89vesicle docking involved in exocytosis (GO:0006904)2.90487885
90positive regulation of neurotransmitter secretion (GO:0001956)2.89172918
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.88432233
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87641116
93amino acid import (GO:0043090)2.87485570
94positive regulation of chemokine secretion (GO:0090197)2.86276672
95regulation of neurotransmitter secretion (GO:0046928)2.85186746
96regulation of interleukin-13 production (GO:0032656)2.81572255
97neuromuscular process controlling balance (GO:0050885)2.81183511
98establishment of nucleus localization (GO:0040023)2.80732000
99cellular sodium ion homeostasis (GO:0006883)2.80405368
100mitochondrion localization (GO:0051646)2.80128422
101cerebral cortex radially oriented cell migration (GO:0021799)2.79712345
102glutamate receptor signaling pathway (GO:0007215)2.79494187
103regulation of dendritic spine morphogenesis (GO:0061001)2.79180686
104regulation of heart rate by cardiac conduction (GO:0086091)2.77386914
105regulation of neuronal synaptic plasticity (GO:0048168)2.77347470
106positive regulation of neurotransmitter transport (GO:0051590)2.76694791
107cerebellar Purkinje cell differentiation (GO:0021702)2.75298633
108calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74053615
109chromatin assembly (GO:0031497)2.73006922
110dendrite morphogenesis (GO:0048813)2.72989856
111notochord development (GO:0030903)2.72465234
112negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71429181
113regulation of postsynaptic membrane potential (GO:0060078)2.70070072
114regulation of Rap GTPase activity (GO:0032317)2.69838792
115positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69595891
116positive regulation of protein deacetylation (GO:0090312)2.69523915
117positive regulation of membrane potential (GO:0045838)2.69315532
118mitotic sister chromatid segregation (GO:0000070)2.69208963
119regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.69191443
120positive regulation of Rap GTPase activity (GO:0032854)2.69032895
121neurotransmitter transport (GO:0006836)2.68955106
122vesicle docking (GO:0048278)2.67876123
123sodium ion export (GO:0071436)2.67563004
124membrane depolarization (GO:0051899)2.67478865
125neuronal action potential propagation (GO:0019227)2.66424667
126cellular response to cholesterol (GO:0071397)2.65183461
127rRNA transcription (GO:0009303)2.65165625
128synaptic vesicle endocytosis (GO:0048488)2.64892803
129potassium ion import (GO:0010107)2.64643475
130regulation of nuclear cell cycle DNA replication (GO:0033262)2.64081455
131regulation of ARF protein signal transduction (GO:0032012)2.63705974
132stress granule assembly (GO:0034063)2.63592321
133G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.63511074
134intracellular estrogen receptor signaling pathway (GO:0030520)2.63437650
135activation of protein kinase A activity (GO:0034199)2.63172735
136phenol-containing compound catabolic process (GO:0019336)2.63002952
137cardiac conduction (GO:0061337)2.62663378
138positive regulation of muscle cell apoptotic process (GO:0010661)2.62112540
139cerebral cortex neuron differentiation (GO:0021895)2.61558118
140regulation of synaptic plasticity (GO:0048167)2.61163869
141cytoskeletal anchoring at plasma membrane (GO:0007016)2.61066776
142cerebellar granule cell differentiation (GO:0021707)2.59675476
143peptidyl-threonine phosphorylation (GO:0018107)2.58589685
144axon extension (GO:0048675)2.57999390
145behavioral defense response (GO:0002209)2.57750328
146behavioral fear response (GO:0001662)2.57750328
147nuclear pore complex assembly (GO:0051292)2.57380614
148response to parathyroid hormone (GO:0071107)2.57240837
149phosphatidylinositol 3-kinase signaling (GO:0014065)2.56620088
150central nervous system projection neuron axonogenesis (GO:0021952)2.56204996
151regulation of NFAT protein import into nucleus (GO:0051532)2.56035982
152neuron cell-cell adhesion (GO:0007158)2.55885677
153mRNA stabilization (GO:0048255)2.55105969
154RNA stabilization (GO:0043489)2.55105969
155intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.54899147
156regulation of neurotransmitter transport (GO:0051588)2.53920152
157ventricular cardiac muscle cell action potential (GO:0086005)2.53910646
158membrane assembly (GO:0071709)2.53838836
159establishment of mitochondrion localization (GO:0051654)2.53729095
160negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52777530
161tachykinin receptor signaling pathway (GO:0007217)2.52671610
162regulation of synaptic vesicle transport (GO:1902803)2.52633172
163sister chromatid segregation (GO:0000819)2.52256034
164maternal placenta development (GO:0001893)2.52255924
165hormone catabolic process (GO:0042447)2.52161036
166neuron-neuron synaptic transmission (GO:0007270)2.51707688
167regulation of vesicle fusion (GO:0031338)2.50851958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.09982809
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.09982809
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.09982809
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.64509660
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.15304050
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.97037093
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.82400879
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57691327
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.55235031
10EZH2_22144423_ChIP-Seq_EOC_Human2.54752809
11ZFP281_27345836_Chip-Seq_ESCs_Mouse2.49388532
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.37438454
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.28849658
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.26383907
15SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.25149713
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24979108
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17207051
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15858663
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14406454
20KDM2B_26808549_Chip-Seq_K562_Human2.13907854
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.08557774
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.04354876
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97203981
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.96973087
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95726119
26NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.94163256
27GBX2_23144817_ChIP-Seq_PC3_Human1.89390057
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84903826
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.76402237
30TCF3_18692474_ChIP-Seq_MESCs_Mouse1.76225532
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75622882
32MYC_22102868_ChIP-Seq_BL_Human1.75470675
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70902845
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70902845
35KDM2B_26808549_Chip-Seq_DND41_Human1.68855155
36REST_21632747_ChIP-Seq_MESCs_Mouse1.68061749
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.64791700
38EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63593807
39AR_21572438_ChIP-Seq_LNCaP_Human1.63217226
40TCF7_22412390_ChIP-Seq_EML_Mouse1.61997614
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.57402559
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.56576826
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.55860591
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54190142
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.53109155
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52927135
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50835243
48* RING1B_27294783_Chip-Seq_NPCs_Mouse1.50834542
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50105990
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47158319
51TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.46979056
52LXR_22292898_ChIP-Seq_THP-1_Human1.44910709
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41846570
54TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.41617500
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41503516
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40953631
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.39729327
58PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37561505
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36824899
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.35638171
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.35452547
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34555150
63* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33819275
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32938041
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32298555
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31037241
67DROSHA_22980978_ChIP-Seq_HELA_Human1.29019169
68* CTCF_27219007_Chip-Seq_Bcells_Human1.28837413
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27924003
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27477824
71SMC4_20622854_ChIP-Seq_HELA_Human1.23467651
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22682791
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22245142
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22106638
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22098870
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21924689
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19186012
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18401352
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18319077
80E2F1_17053090_ChIP-ChIP_MCF-7_Human1.16814499
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16727494
82TRIM28_21343339_ChIP-Seq_HEK293_Human1.16333191
83TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15218179
84TET1_21490601_ChIP-Seq_MESCs_Mouse1.14981827
85SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14802143
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14745576
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14310415
88TP53_22127205_ChIP-Seq_IMR90_Human1.14206842
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13498612
90CDX2_20551321_ChIP-Seq_CACO-2_Human1.13047644
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12707116
92GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12146633
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.11722630
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.11595656
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11434732
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10931945
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.10716520
98NANOG_16518401_ChIP-PET_MESCs_Mouse1.09647721
99POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08567675
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08202752
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08126006
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07961049
103GATA1_26923725_Chip-Seq_HPCs_Mouse1.07767267
104CREB1_26743006_Chip-Seq_LNCaP_Human1.07335314
105EZH2_27304074_Chip-Seq_ESCs_Mouse1.07036421
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.06563756
107SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04957473
108NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04466908
109NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04233745
110CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02332740
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01810134
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.00146214
113DPY_21335234_ChIP-Seq_ESCs_Mouse1.00044989
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99932357
115* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96707366
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.95734029
117AR_19668381_ChIP-Seq_PC3_Human0.95017797
118ELK4_26923725_Chip-Seq_MESODERM_Mouse0.94942699
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94505472
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94437706
121FOXM1_23109430_ChIP-Seq_U2OS_Human0.93324567
122MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.92896753
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92812819
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92500448
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92083102
126RNF2_27304074_Chip-Seq_NSC_Mouse0.91946169
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91297524
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90311751
129MYC_27129775_Chip-Seq_CORNEA_Mouse0.89141770
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86861730
131NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83725418
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.82570436
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.81807494
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.81192127
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81112476
136OCT4_19829295_ChIP-Seq_ESCs_Human0.78918865
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78773045
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77537692
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.76970701
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76896818
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75216429
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74151594
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.73890344

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.02115330
2MP0004858_abnormal_nervous_system4.18056719
3MP0004270_analgesia2.85564739
4MP0003122_maternal_imprinting2.85079396
5MP0003705_abnormal_hypodermis_morpholog2.81017475
6MP0005499_abnormal_olfactory_system2.73412255
7MP0005394_taste/olfaction_phenotype2.73412255
8MP0003635_abnormal_synaptic_transmissio2.72373808
9MP0003890_abnormal_embryonic-extraembry2.55308336
10MP0008961_abnormal_basal_metabolism2.47949917
11MP0002254_reproductive_system_inflammat2.35378581
12MP0002063_abnormal_learning/memory/cond2.31247041
13MP0004264_abnormal_extraembryonic_tissu2.27735858
14MP0004742_abnormal_vestibular_system2.18031931
15MP0002735_abnormal_chemical_nociception2.14973322
16MP0006292_abnormal_olfactory_placode2.08510568
17MP0003011_delayed_dark_adaptation2.04396105
18MP0003121_genomic_imprinting1.93595896
19MP0010352_gastrointestinal_tract_polyps1.87645548
20MP0002572_abnormal_emotion/affect_behav1.87343476
21MP0000751_myopathy1.87156449
22MP0003787_abnormal_imprinting1.80745379
23MP0002064_seizures1.80594108
24MP0009046_muscle_twitch1.80247744
25MP0002736_abnormal_nociception_after1.78991679
26MP0001348_abnormal_lacrimal_gland1.74278015
27MP0009745_abnormal_behavioral_response1.72599257
28MP0003880_abnormal_central_pattern1.72229897
29MP0002653_abnormal_ependyma_morphology1.71662610
30MP0002332_abnormal_exercise_endurance1.71376192
31MP0002909_abnormal_adrenal_gland1.70319813
32MP0001486_abnormal_startle_reflex1.64292164
33MP0003879_abnormal_hair_cell1.62737604
34MP0000778_abnormal_nervous_system1.62236376
35MP0005623_abnormal_meninges_morphology1.62193246
36MP0001502_abnormal_circadian_rhythm1.60193989
37MP0002734_abnormal_mechanical_nocicepti1.58724508
38MP0003283_abnormal_digestive_organ1.56649701
39MP0000955_abnormal_spinal_cord1.55575255
40MP0003123_paternal_imprinting1.53536645
41MP0002733_abnormal_thermal_nociception1.51201503
42MP0005257_abnormal_intraocular_pressure1.50130770
43MP0004811_abnormal_neuron_physiology1.49885716
44MP0005423_abnormal_somatic_nervous1.48097777
45MP0002184_abnormal_innervation1.41036716
46MP0003938_abnormal_ear_development1.40148650
47MP0001849_ear_inflammation1.37587759
48MP0006276_abnormal_autonomic_nervous1.31466994
49MP0003119_abnormal_digestive_system1.24219949
50MP0000534_abnormal_ureter_morphology1.24177122
51MP0008770_decreased_survivor_rate1.22507098
52MP0009780_abnormal_chondrocyte_physiolo1.20409416
53MP0006035_abnormal_mitochondrial_morpho1.18042854
54MP0003137_abnormal_impulse_conducting1.17980526
55MP0001970_abnormal_pain_threshold1.15842560
56MP0003861_abnormal_nervous_system1.15442246
57MP0001177_atelectasis1.12824103
58MP0003634_abnormal_glial_cell1.12514382
59MP0005380_embryogenesis_phenotype1.10590961
60MP0001672_abnormal_embryogenesis/_devel1.10590961
61MP0001440_abnormal_grooming_behavior1.10084819
62MP0001968_abnormal_touch/_nociception1.08766389
63MP0004130_abnormal_muscle_cell1.07765657
64MP0005248_abnormal_Harderian_gland1.06100205
65MP0005409_darkened_coat_color1.06070545
66MP0002088_abnormal_embryonic_growth/wei1.05694502
67MP0004885_abnormal_endolymph1.05622570
68MP0002822_catalepsy1.04775088
69MP0002882_abnormal_neuron_morphology1.04617860
70MP0003984_embryonic_growth_retardation1.03354032
71MP0000920_abnormal_myelination1.02886281
72MP0000750_abnormal_muscle_regeneration1.02312105
73MP0002152_abnormal_brain_morphology1.02190429
74MP0002272_abnormal_nervous_system1.02144550
75MP0001501_abnormal_sleep_pattern1.00815214
76MP0001984_abnormal_olfaction1.00662905
77MP0003329_amyloid_beta_deposits1.00463479
78MP0000569_abnormal_digit_pigmentation1.00094017
79MP0000428_abnormal_craniofacial_morphol0.99186656
80MP0001958_emphysema0.99054723
81MP0005075_abnormal_melanosome_morpholog0.98457723
82MP0002932_abnormal_joint_morphology0.98373320
83MP0005076_abnormal_cell_differentiation0.97753191
84MP0003690_abnormal_glial_cell0.96652269
85MP0000678_abnormal_parathyroid_gland0.96467288
86MP0002084_abnormal_developmental_patter0.96343919
87MP0002127_abnormal_cardiovascular_syste0.96201482
88MP0001485_abnormal_pinna_reflex0.95441567
89MP0002557_abnormal_social/conspecific_i0.93040764
90MP0001963_abnormal_hearing_physiology0.92879477
91MP0000049_abnormal_middle_ear0.92556817
92MP0002249_abnormal_larynx_morphology0.91309368
93MP0000015_abnormal_ear_pigmentation0.90618527
94MP0002086_abnormal_extraembryonic_tissu0.90297571
95MP0001943_abnormal_respiration0.88651639
96MP0008789_abnormal_olfactory_epithelium0.88602950
97MP0003935_abnormal_craniofacial_develop0.88478016
98MP0002269_muscular_atrophy0.88416433
99MP0005187_abnormal_penis_morphology0.88174340
100MP0001299_abnormal_eye_distance/0.88120843
101MP0002085_abnormal_embryonic_tissue0.87548500
102MP0002752_abnormal_somatic_nervous0.87357342
103* MP0002081_perinatal_lethality0.87037178
104MP0003172_abnormal_lysosome_physiology0.86321854
105MP0003183_abnormal_peptide_metabolism0.86239064
106MP0008569_lethality_at_weaning0.85828473
107MP0002092_abnormal_eye_morphology0.85156932
108MP0002066_abnormal_motor_capabilities/c0.85051553
109MP0002233_abnormal_nose_morphology0.84758006
110MP0003755_abnormal_palate_morphology0.82981855
111MP0004197_abnormal_fetal_growth/weight/0.82961468
112MP0004085_abnormal_heartbeat0.82305631
113MP0000759_abnormal_skeletal_muscle0.82181041
114MP0000762_abnormal_tongue_morphology0.82098669
115MP0003631_nervous_system_phenotype0.81788165
116MP0003942_abnormal_urinary_system0.81690472
117MP0004924_abnormal_behavior0.81460653
118MP0005386_behavior/neurological_phenoty0.81460653
119MP0003632_abnormal_nervous_system0.81357520
120MP0000026_abnormal_inner_ear0.81077580
121MP0002067_abnormal_sensory_capabilities0.79968918
122MP0002925_abnormal_cardiovascular_devel0.79361581
123MP0000350_abnormal_cell_proliferation0.77710516
124* MP0002114_abnormal_axial_skeleton0.77399691
125MP0009703_decreased_birth_body0.76746669
126MP0008874_decreased_physiological_sensi0.76418530
127MP0002116_abnormal_craniofacial_bone0.76269733
128MP0004087_abnormal_muscle_fiber0.76166609
129MP0002069_abnormal_eating/drinking_beha0.76071552
130MP0000537_abnormal_urethra_morphology0.75880957
131MP0002106_abnormal_muscle_physiology0.75834381
132MP0004145_abnormal_muscle_electrophysio0.74935477
133MP0000631_abnormal_neuroendocrine_gland0.74719558
134MP0000747_muscle_weakness0.74598616
135MP0010769_abnormal_survival0.73674909
136MP0008057_abnormal_DNA_replication0.73045239
137MP0001293_anophthalmia0.72938286
138MP0003633_abnormal_nervous_system0.72360193
139MP0010770_preweaning_lethality0.71382503
140MP0002082_postnatal_lethality0.71382503
141MP0010768_mortality/aging0.69039919
142MP0002896_abnormal_bone_mineralization0.68251382
143MP0002229_neurodegeneration0.66125267
144MP0005369_muscle_phenotype0.65162506
145MP0000579_abnormal_nail_morphology0.62731386

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)5.43454887
2Bilateral microphthalmos (HP:0007633)4.95688331
3Hepatoblastoma (HP:0002884)4.80635439
4Hypochromic microcytic anemia (HP:0004840)4.05856046
5Amyotrophic lateral sclerosis (HP:0007354)3.94766533
6Ependymoma (HP:0002888)3.61638151
7Astrocytoma (HP:0009592)3.49712606
8Abnormality of the astrocytes (HP:0100707)3.49712606
9Conjugated hyperbilirubinemia (HP:0002908)3.33669430
10Abnormality of the right ventricle (HP:0001707)3.31953295
11Rectal prolapse (HP:0002035)3.19046318
12Thin ribs (HP:0000883)3.03425345
13Cerebral hypomyelination (HP:0006808)3.01499653
14Rib fusion (HP:0000902)2.99532209
15Vitreoretinal degeneration (HP:0000655)2.99271555
16Multiple enchondromatosis (HP:0005701)2.98536831
17Focal seizures (HP:0007359)2.94319105
18Obstructive sleep apnea (HP:0002870)2.93983101
19Difficulty running (HP:0009046)2.88764184
20Myokymia (HP:0002411)2.88457675
21Fetal akinesia sequence (HP:0001989)2.88446630
22Amblyopia (HP:0000646)2.78732096
23Neoplasm of striated muscle (HP:0009728)2.78648024
24Turricephaly (HP:0000262)2.72908323
25Generalized hypotonia (HP:0001290)2.72074753
26Achilles tendon contracture (HP:0001771)2.70760706
27Neoplasm of the heart (HP:0100544)2.70676419
28Resting tremor (HP:0002322)2.69607309
29Renal duplication (HP:0000075)2.68324188
30Macroorchidism (HP:0000053)2.68133825
31Epileptic encephalopathy (HP:0200134)2.66795516
32Neurofibrillary tangles (HP:0002185)2.65707114
33Mitral regurgitation (HP:0001653)2.64885442
34Hip dysplasia (HP:0001385)2.64160755
35Hyperventilation (HP:0002883)2.60009449
36Horizontal nystagmus (HP:0000666)2.59107076
37Abnormality of the corticospinal tract (HP:0002492)2.55673673
38Morphological abnormality of the middle ear (HP:0008609)2.53792336
39Insomnia (HP:0100785)2.48510569
40Abnormality of the ischium (HP:0003174)2.48469642
41Visual hallucinations (HP:0002367)2.46693065
42Ulnar bowing (HP:0003031)2.44944218
43Abnormality of the Achilles tendon (HP:0005109)2.41376457
44Hypoplastic ischia (HP:0003175)2.39510965
45Cerebral inclusion bodies (HP:0100314)2.39191193
46Febrile seizures (HP:0002373)2.39169843
47Morphological abnormality of the inner ear (HP:0011390)2.39071531
48Glioma (HP:0009733)2.38944853
49Ankle clonus (HP:0011448)2.35898746
50Hand muscle atrophy (HP:0009130)2.34032518
51Rhabdomyosarcoma (HP:0002859)2.33476216
52Hemiparesis (HP:0001269)2.31975787
53Abnormality of the aortic arch (HP:0012303)2.29061588
54Ankyloglossia (HP:0010296)2.28869710
55Long clavicles (HP:0000890)2.28516925
56Upper limb amyotrophy (HP:0009129)2.28349040
57Distal upper limb amyotrophy (HP:0007149)2.28349040
58Apathy (HP:0000741)2.26218538
59Large earlobe (HP:0009748)2.20498747
60Poor eye contact (HP:0000817)2.20411038
61Megalencephaly (HP:0001355)2.19468076
62Tetraplegia (HP:0002445)2.18405512
63Vertebral arch anomaly (HP:0008438)2.16082931
64Delusions (HP:0000746)2.15802467
65Abnormality of binocular vision (HP:0011514)2.15082136
66Diplopia (HP:0000651)2.15082136
6711 pairs of ribs (HP:0000878)2.14753924
68Excessive salivation (HP:0003781)2.14653698
69Drooling (HP:0002307)2.14653698
70Abnormality of chromosome segregation (HP:0002916)2.13914450
71Dialeptic seizures (HP:0011146)2.12508949
72Focal motor seizures (HP:0011153)2.11877632
73Pseudobulbar signs (HP:0002200)2.10756917
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10645342
75Wide anterior fontanel (HP:0000260)2.08914726
76Testicular atrophy (HP:0000029)2.08612987
77Thickened calvaria (HP:0002684)2.06127283
78Malignant neoplasm of the central nervous system (HP:0100836)2.05445533
79Atonic seizures (HP:0010819)2.04776490
80Abnormal eating behavior (HP:0100738)2.04636451
81Fused cervical vertebrae (HP:0002949)2.04330178
82Shallow orbits (HP:0000586)2.03635773
83Supranuclear gaze palsy (HP:0000605)2.03558682
84Renovascular hypertension (HP:0100817)2.03355101
85Elfin facies (HP:0004428)2.02181030
86Bronchomalacia (HP:0002780)2.01773991
87Type 1 muscle fiber predominance (HP:0003803)1.99294211
88Metabolic alkalosis (HP:0200114)1.98685064
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98541974
90Papilledema (HP:0001085)1.98317724
91Diminished motivation (HP:0000745)1.98181082
92Hypopigmentation of the fundus (HP:0007894)1.98162288
93Megalocornea (HP:0000485)1.96868012
94Abnormality of the 4th metacarpal (HP:0010012)1.96508852
95Nephroblastoma (Wilms tumor) (HP:0002667)1.96462469
96Pheochromocytoma (HP:0002666)1.96296083
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.96049709
98Short 4th metacarpal (HP:0010044)1.95994794
99Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95994794
100Abnormality of the calcaneus (HP:0008364)1.95668515
101Open mouth (HP:0000194)1.93330811
102Increased connective tissue (HP:0009025)1.92508206
103Aplasia involving bones of the extremities (HP:0009825)1.92215834
104Aplasia involving bones of the upper limbs (HP:0009823)1.92215834
105Aplasia of the phalanges of the hand (HP:0009802)1.92215834
106Generalized tonic-clonic seizures (HP:0002069)1.91843999
107Annular pancreas (HP:0001734)1.91783769
108Short chin (HP:0000331)1.91763738
109Spastic gait (HP:0002064)1.91246357
110Akinesia (HP:0002304)1.88980203
111Neuroectodermal neoplasm (HP:0030061)1.88974654
112Neuroepithelial neoplasm (HP:0030063)1.88974654
113Nervous tissue neoplasm (HP:0030060)1.88974654
114Abnormality of the musculature of the hand (HP:0001421)1.87398015
115Inappropriate behavior (HP:0000719)1.87253019
116Adenoma sebaceum (HP:0009720)1.86570837
117Angiofibromas (HP:0010615)1.86570837
118Abnormal EKG (HP:0003115)1.86498698
119Torticollis (HP:0000473)1.86464029
120Abnormality of the nasal septum (HP:0000419)1.86455917
121Status epilepticus (HP:0002133)1.85793946
122Short humerus (HP:0005792)1.85333957
123Hammertoe (HP:0001765)1.84835684
124Intellectual disability, profound (HP:0002187)1.84567322
125Overriding aorta (HP:0002623)1.84469473
126Craniofacial hyperostosis (HP:0004493)1.84148782
127Abnormality of the salivary glands (HP:0010286)1.83017722
128Embryonal renal neoplasm (HP:0011794)1.82966140
129Lymphangioma (HP:0100764)1.82845636
130Absence seizures (HP:0002121)1.82139779
131Broad palm (HP:0001169)1.81940549
132Shawl scrotum (HP:0000049)1.81876315
133Fibroma (HP:0010614)1.81554461
134Heterotopia (HP:0002282)1.81333052
135Abnormality of incisor morphology (HP:0011063)1.81185705
136Action tremor (HP:0002345)1.81021689
137Urinary bladder sphincter dysfunction (HP:0002839)1.80488991
138EMG: neuropathic changes (HP:0003445)1.79973924
139Fibular hypoplasia (HP:0003038)1.78650344
140Impaired vibration sensation in the lower limbs (HP:0002166)1.78456266
141Skin tags (HP:0010609)1.77870536
142Preauricular skin tag (HP:0000384)1.77839789
143Missing ribs (HP:0000921)1.77523790
144Abnormality of the pubic bones (HP:0003172)1.77491097
145Abnormality of the lumbar spine (HP:0100712)1.77109329
146Spastic tetraparesis (HP:0001285)1.77013964
147Hypokalemic alkalosis (HP:0001949)1.74743350
148Leiomyosarcoma (HP:0100243)1.74534404
149Uterine leiomyosarcoma (HP:0002891)1.74534404
150Depression (HP:0000716)1.73965240
151Bowel diverticulosis (HP:0005222)1.73647872
152Cutaneous syndactyly (HP:0012725)1.73640081
153Overgrowth (HP:0001548)1.73289903
154Ragged-red muscle fibers (HP:0003200)1.72589260
155Lower limb amyotrophy (HP:0007210)1.72404625
156Fibrous tissue neoplasm (HP:0012316)1.72055578
157Oligodactyly (hands) (HP:0001180)1.71673543
158Increased variability in muscle fiber diameter (HP:0003557)1.71105688
159Absent frontal sinuses (HP:0002688)1.70883650
160Mutism (HP:0002300)1.70821405
161Impaired social interactions (HP:0000735)1.70400572
162Abnormal social behavior (HP:0012433)1.70400572
163Rectal fistula (HP:0100590)1.69720672
164Rectovaginal fistula (HP:0000143)1.69720672
165Aplasia/hypoplasia of the humerus (HP:0006507)1.69382914
166Hyperacusis (HP:0010780)1.69033077
167Abnormality of oral frenula (HP:0000190)1.68826154
168Pointed chin (HP:0000307)1.68038438
169Round face (HP:0000311)1.67790105
170Flat cornea (HP:0007720)1.66732627
171Neonatal short-limb short stature (HP:0008921)1.66683740
172Tracheomalacia (HP:0002779)1.65137087
173Increased nuchal translucency (HP:0010880)1.63977930
174Aplasia/Hypoplasia of the sternum (HP:0006714)1.63297273
175Cutaneous finger syndactyly (HP:0010554)1.63287031
176Metaphyseal cupping (HP:0003021)1.63190202
177Tubulointerstitial fibrosis (HP:0005576)1.62679362
178Limb dystonia (HP:0002451)1.62646886

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.63536806
2GRK53.77033032
3LATS13.71606544
4MAP3K93.27741979
5MARK13.09873187
6TYRO32.94794817
7GRK62.86546474
8CASK2.56618802
9ERN12.46819704
10NTRK32.19549669
11NTRK12.17630494
12EPHA42.05185430
13PNCK1.92617409
14MAP2K41.89083306
15PAK61.88444427
16LATS21.84196858
17ALK1.69074388
18SIK21.65079288
19CSF1R1.61765042
20NTRK21.55210932
21MAP3K41.54208288
22MARK21.52651662
23TRIB31.51005738
24MAP3K101.47435619
25WNK11.46735259
26MAPK71.44310537
27MINK11.44185227
28KSR21.43005594
29CDK31.40131267
30PRKD31.37394332
31MATK1.35787643
32DAPK21.33849698
33RIPK11.31071104
34TGFBR21.30021568
35MOS1.29199943
36SGK4941.23393279
37SGK2231.23393279
38CAMK41.21658111
39TAOK11.17429542
40EPHB21.16730631
41PKN21.16392809
42ADRBK21.15055228
43GRK71.13011291
44CAMKK11.12967819
45GRK11.12753061
46MAP3K131.10911190
47SGK21.10544626
48SIK11.09760619
49PDGFRA1.05933134
50SGK31.04746042
51MAP3K71.02942951
52PHKG11.01956326
53PHKG21.01956326
54STK381.00732393
55NUAK10.97979762
56KSR10.97015303
57ICK0.92393278
58STK100.90772998
59EEF2K0.87093402
60MAPK120.86687935
61CDK50.85904999
62FGFR30.83931232
63TTK0.82917301
64OBSCN0.80103422
65BMX0.78502808
66HIPK20.77545899
67CDK190.77467932
68CDK150.77307197
69SCYL20.76303585
70CAMK2B0.75507190
71DDR20.74420779
72PAK30.73689141
73PDPK10.72895131
74CDK180.72118242
75NEK10.70608779
76FGFR10.70539688
77RET0.70509563
78DYRK1B0.69555864
79CSNK1G10.69086142
80PRKCH0.68484130
81ROCK20.67807357
82CDK140.67480644
83CDK11A0.66809418
84DAPK10.65484268
85PRKCG0.64346553
86STK110.63998109
87SGK10.63662776
88MTOR0.63661379
89PRKG20.63142466
90ROCK10.59988074
91PRPF4B0.59753897
92ADRBK10.59353702
93PAK40.59030202
94CAMK1G0.58175234
95CAMK2A0.57653268
96MAP2K60.55903683
97UHMK10.55565413
98YES10.55471960
99MAPK100.51699336
100MAP2K20.51274312
101ARAF0.50531181
102PTK20.49458626
103RPS6KB10.49297775
104DYRK1A0.49277517
105PDK10.47112290
106LIMK10.46794623
107AKT20.46476465
108DMPK0.45639901
109CHEK20.43969738
110NEK60.43667456
111RPS6KA30.43661921
112TTN0.42873638
113PKN10.40816249
114GSK3A0.40752638
115MAPK80.40329709
116CSNK1E0.39377645
117FGFR20.38688253
118RAF10.38649196
119RIPK40.38329440
120PRKCZ0.37804112
121CAMK10.37444926
122MAP2K70.37215560
123MAP3K20.37129775
124FYN0.36185458
125CHEK10.35207309
126PRKD20.34816345
127CDK20.33783293
128MAPK130.33124853
129CAMK1D0.32457087
130CSK0.31894990
131GSK3B0.31367031
132PLK20.31181000
133ERBB20.30908930
134CSNK1D0.30720493
135DYRK20.30654220

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.62429744
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23374821
3Long-term potentiation_Homo sapiens_hsa047202.13348345
4Glutamatergic synapse_Homo sapiens_hsa047241.93111823
5mTOR signaling pathway_Homo sapiens_hsa041501.90066089
6GABAergic synapse_Homo sapiens_hsa047271.89405841
7Olfactory transduction_Homo sapiens_hsa047401.76207745
8Nicotine addiction_Homo sapiens_hsa050331.72160465
9Synaptic vesicle cycle_Homo sapiens_hsa047211.72026277
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68791993
11Circadian entrainment_Homo sapiens_hsa047131.63397164
12Vitamin B6 metabolism_Homo sapiens_hsa007501.57932313
13Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.56550831
14Dopaminergic synapse_Homo sapiens_hsa047281.54278374
15GnRH signaling pathway_Homo sapiens_hsa049121.49683109
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49393880
17Glioma_Homo sapiens_hsa052141.49298697
18Oxytocin signaling pathway_Homo sapiens_hsa049211.48796451
19Salivary secretion_Homo sapiens_hsa049701.45364260
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44838876
21Long-term depression_Homo sapiens_hsa047301.42729218
22Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.42563552
23Phospholipase D signaling pathway_Homo sapiens_hsa040721.40919616
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38176357
25Morphine addiction_Homo sapiens_hsa050321.38144665
26Amphetamine addiction_Homo sapiens_hsa050311.33049154
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28049304
28Non-small cell lung cancer_Homo sapiens_hsa052231.28007643
29Cholinergic synapse_Homo sapiens_hsa047251.27957931
30Nitrogen metabolism_Homo sapiens_hsa009101.27707287
31Gap junction_Homo sapiens_hsa045401.27566921
32Renin secretion_Homo sapiens_hsa049241.27184213
33VEGF signaling pathway_Homo sapiens_hsa043701.26860971
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.25847581
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24665944
36Axon guidance_Homo sapiens_hsa043601.23559187
37Gastric acid secretion_Homo sapiens_hsa049711.23342598
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21853119
39ErbB signaling pathway_Homo sapiens_hsa040121.19986823
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.19432260
41Estrogen signaling pathway_Homo sapiens_hsa049151.17344517
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12837087
43Choline metabolism in cancer_Homo sapiens_hsa052311.12460352
44Endometrial cancer_Homo sapiens_hsa052131.11220009
45Fructose and mannose metabolism_Homo sapiens_hsa000511.10123629
46Dorso-ventral axis formation_Homo sapiens_hsa043201.09979001
47Colorectal cancer_Homo sapiens_hsa052101.07060320
48cAMP signaling pathway_Homo sapiens_hsa040241.06933324
49Calcium signaling pathway_Homo sapiens_hsa040201.06678585
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.06259253
51Rap1 signaling pathway_Homo sapiens_hsa040151.06008988
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.03666421
53Serotonergic synapse_Homo sapiens_hsa047261.03652156
54Taste transduction_Homo sapiens_hsa047421.02435361
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02406923
56Insulin secretion_Homo sapiens_hsa049111.02019510
57Dilated cardiomyopathy_Homo sapiens_hsa054140.98681955
58* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95511122
59Type II diabetes mellitus_Homo sapiens_hsa049300.94883782
60Melanogenesis_Homo sapiens_hsa049160.92189920
61Renal cell carcinoma_Homo sapiens_hsa052110.89425397
62MAPK signaling pathway_Homo sapiens_hsa040100.89000357
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88651411
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88355013
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87787060
66Cocaine addiction_Homo sapiens_hsa050300.86375851
67Oocyte meiosis_Homo sapiens_hsa041140.85476527
68Thyroid cancer_Homo sapiens_hsa052160.85081402
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85077877
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83631609
71Proteoglycans in cancer_Homo sapiens_hsa052050.82667105
72* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82513222
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79519295
74Prion diseases_Homo sapiens_hsa050200.79151544
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.78709957
76Wnt signaling pathway_Homo sapiens_hsa043100.78702414
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78307232
78Notch signaling pathway_Homo sapiens_hsa043300.77217107
79Thyroid hormone synthesis_Homo sapiens_hsa049180.76651712
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76375831
81Hippo signaling pathway_Homo sapiens_hsa043900.76153064
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.75787518
83Bile secretion_Homo sapiens_hsa049760.74623039
84Ras signaling pathway_Homo sapiens_hsa040140.73974751
85Adherens junction_Homo sapiens_hsa045200.73915424
86Pancreatic cancer_Homo sapiens_hsa052120.72851745
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70567828
88Phototransduction_Homo sapiens_hsa047440.70400570
89Chronic myeloid leukemia_Homo sapiens_hsa052200.70106846
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69825549
91AMPK signaling pathway_Homo sapiens_hsa041520.69620791
92MicroRNAs in cancer_Homo sapiens_hsa052060.69416315
93Glucagon signaling pathway_Homo sapiens_hsa049220.68796197
94Insulin signaling pathway_Homo sapiens_hsa049100.66109900
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66053867
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64758263
97Endocytosis_Homo sapiens_hsa041440.64468201
98Hedgehog signaling pathway_Homo sapiens_hsa043400.64010869
99FoxO signaling pathway_Homo sapiens_hsa040680.63736613
100B cell receptor signaling pathway_Homo sapiens_hsa046620.63339186
101ECM-receptor interaction_Homo sapiens_hsa045120.62860794
102mRNA surveillance pathway_Homo sapiens_hsa030150.62733714
103Focal adhesion_Homo sapiens_hsa045100.60845580
104Pancreatic secretion_Homo sapiens_hsa049720.60415252
105Galactose metabolism_Homo sapiens_hsa000520.60296942
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59622686
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59580428
108Basal cell carcinoma_Homo sapiens_hsa052170.59529045
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58353239
110Acute myeloid leukemia_Homo sapiens_hsa052210.57757498
111Bladder cancer_Homo sapiens_hsa052190.57240623
112Tight junction_Homo sapiens_hsa045300.57165590
113T cell receptor signaling pathway_Homo sapiens_hsa046600.55548896
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55313664
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53715645
116Pathways in cancer_Homo sapiens_hsa052000.52999048
117Prolactin signaling pathway_Homo sapiens_hsa049170.52570863
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52323140
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52311028
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50383762

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