PIP4K2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.01120517
2hemidesmosome assembly (GO:0031581)5.94976747
3COPI coating of Golgi vesicle (GO:0048205)5.28335687
4Golgi transport vesicle coating (GO:0048200)5.28335687
5regulation of water loss via skin (GO:0033561)4.87575409
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.77998084
7sodium ion export (GO:0071436)4.35269487
8synaptic vesicle maturation (GO:0016188)4.03185405
9establishment of skin barrier (GO:0061436)3.99589593
10activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.96328690
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.91946239
12regulation of early endosome to late endosome transport (GO:2000641)3.80897510
13activation of Rac GTPase activity (GO:0032863)3.78812858
14positive regulation of nuclease activity (GO:0032075)3.76650375
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71202181
16regulation of clathrin-mediated endocytosis (GO:2000369)3.65083537
17phosphate ion transport (GO:0006817)3.64356672
18protein localization to endosome (GO:0036010)3.62761300
19protein retention in ER lumen (GO:0006621)3.61700578
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.55764182
21multicellular organismal water homeostasis (GO:0050891)3.52112618
22thyroid hormone generation (GO:0006590)3.47060244
23COPII vesicle coating (GO:0048208)3.46876286
24positive regulation of histone deacetylation (GO:0031065)3.46373050
25response to parathyroid hormone (GO:0071107)3.41008075
26macroautophagy (GO:0016236)3.40225185
27intestinal epithelial cell development (GO:0060576)3.39284377
28regulation of nuclease activity (GO:0032069)3.37661663
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.37218698
30endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.34916813
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31896487
32regulation of cholesterol homeostasis (GO:2000188)3.29007066
33phosphate ion transmembrane transport (GO:0035435)3.28286046
34stress fiber assembly (GO:0043149)3.26632450
35regulation of hippo signaling (GO:0035330)3.26367677
36cellular potassium ion homeostasis (GO:0030007)3.22297514
37endoplasmic reticulum unfolded protein response (GO:0030968)3.21373610
38cell-substrate junction assembly (GO:0007044)3.20115205
39protein localization to microtubule (GO:0035372)3.18356432
40positive regulation of keratinocyte differentiation (GO:0045618)3.16128747
41L-alpha-amino acid transmembrane transport (GO:1902475)3.15921000
42positive regulation of macroautophagy (GO:0016239)3.14989920
43L-serine transport (GO:0015825)3.14741814
44proline biosynthetic process (GO:0006561)3.14253529
45positive regulation of Cdc42 GTPase activity (GO:0043089)3.12173171
46positive regulation of epidermal cell differentiation (GO:0045606)3.10053724
47skin morphogenesis (GO:0043589)3.09940532
48keratinocyte proliferation (GO:0043616)3.07950965
49negative regulation of cell size (GO:0045792)3.06892166
50cellular response to unfolded protein (GO:0034620)3.06233344
51water homeostasis (GO:0030104)3.05590117
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.01576130
53CDP-diacylglycerol metabolic process (GO:0046341)3.01014148
54regulation of short-term neuronal synaptic plasticity (GO:0048172)2.99025075
55glucose 6-phosphate metabolic process (GO:0051156)2.98962854
56actin filament depolymerization (GO:0030042)2.98922766
57lysine metabolic process (GO:0006553)2.98840064
58lysine catabolic process (GO:0006554)2.98840064
59branching involved in mammary gland duct morphogenesis (GO:0060444)2.96346795
60tricarboxylic acid metabolic process (GO:0072350)2.95548132
61ER-nucleus signaling pathway (GO:0006984)2.91828435
62regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.90931024
63cellular response to topologically incorrect protein (GO:0035967)2.88382695
64negative regulation of keratinocyte proliferation (GO:0010839)2.88237660
65myelin maintenance (GO:0043217)2.86508052
66hormone catabolic process (GO:0042447)2.85591266
67negative regulation of dendrite morphogenesis (GO:0050774)2.85012865
68locomotory exploration behavior (GO:0035641)2.84907258
69membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.84761012
70calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.82117901
71amyloid precursor protein metabolic process (GO:0042982)2.81979435
72mating behavior (GO:0007617)2.81861511
73glutamate secretion (GO:0014047)2.78745791
74ER overload response (GO:0006983)2.78102113
75negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77686348
76vitamin transmembrane transport (GO:0035461)2.77545814
77thyroid hormone metabolic process (GO:0042403)2.77472522
78positive regulation of epidermis development (GO:0045684)2.76459446
79regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.76454826
80apoptotic cell clearance (GO:0043277)2.74204135
81cellular copper ion homeostasis (GO:0006878)2.73942413
82regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.72962687
83regulation of translational termination (GO:0006449)2.72952623
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.72715070
85mammary gland epithelial cell proliferation (GO:0033598)2.70627613
86hepatocyte apoptotic process (GO:0097284)2.70075294
87regulation of ARF protein signal transduction (GO:0032012)2.69935896
88transferrin transport (GO:0033572)2.69141555
89cell communication by electrical coupling (GO:0010644)2.68673796
90CDP-diacylglycerol biosynthetic process (GO:0016024)2.67601338
91regulation of cholesterol biosynthetic process (GO:0045540)2.67581505
92cellular zinc ion homeostasis (GO:0006882)2.67115700
93tight junction assembly (GO:0070830)2.66818836
94hypotonic response (GO:0006971)2.65603556
95proline transport (GO:0015824)2.65449431
96membrane repolarization during action potential (GO:0086011)2.65448297
974-hydroxyproline metabolic process (GO:0019471)2.64788750
98valine metabolic process (GO:0006573)2.64731015
99serine transport (GO:0032329)2.64679443
100focal adhesion assembly (GO:0048041)2.64471662
101cell-substrate adherens junction assembly (GO:0007045)2.64471662
102amyloid precursor protein catabolic process (GO:0042987)2.64250535
103negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.62492172
104establishment of protein localization to plasma membrane (GO:0090002)2.61703844
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.61647641
106keratinocyte development (GO:0003334)2.58485767
107response to endoplasmic reticulum stress (GO:0034976)2.58095447
108cellular modified amino acid catabolic process (GO:0042219)2.57832460
109trivalent inorganic cation transport (GO:0072512)2.56964462
110ferric iron transport (GO:0015682)2.56964462
111peptidyl-tyrosine autophosphorylation (GO:0038083)2.56758345
112protein autoprocessing (GO:0016540)2.56430510
113regulation of transforming growth factor beta1 production (GO:0032908)2.56094584
114negative regulation of hormone metabolic process (GO:0032351)2.54192266
115negative regulation of hormone biosynthetic process (GO:0032353)2.54192266
116maternal placenta development (GO:0001893)2.51733547
117trophectodermal cell differentiation (GO:0001829)2.51146107
118aminoglycoside antibiotic metabolic process (GO:0030647)2.50671916
119surfactant homeostasis (GO:0043129)2.49612874
120regulation of keratinocyte differentiation (GO:0045616)2.48767991
121vesicle coating (GO:0006901)2.48361527
122activation of protein kinase A activity (GO:0034199)2.48076313
123modified amino acid transport (GO:0072337)2.47351450
124cell adhesion mediated by integrin (GO:0033627)2.47348198
125positive regulation of protein deacetylation (GO:0090312)2.46753398
126intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.46450414
127negative regulation of TOR signaling (GO:0032007)2.45509927
128zinc ion transmembrane transport (GO:0071577)2.43530877
129adherens junction assembly (GO:0034333)2.43402932
130sphingomyelin metabolic process (GO:0006684)2.43044524
131potassium ion import (GO:0010107)2.42627416
132growth hormone secretion (GO:0030252)2.42358320
133nucleotide-sugar biosynthetic process (GO:0009226)2.41727187
134negative regulation of protein localization to plasma membrane (GO:1903077)2.40817955
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.40689435
136vesicle targeting (GO:0006903)2.40453048
137norepinephrine metabolic process (GO:0042415)2.39715217
138NADH metabolic process (GO:0006734)2.39292342
139mannose metabolic process (GO:0006013)2.38612133
140positive regulation of actin filament depolymerization (GO:0030836)2.38548270
141regulation of cardioblast differentiation (GO:0051890)2.38114264
142polarized epithelial cell differentiation (GO:0030859)2.37769333
143membrane protein ectodomain proteolysis (GO:0006509)2.37608216
144epithelial cell-cell adhesion (GO:0090136)2.37598726
145cellular sodium ion homeostasis (GO:0006883)2.35873009
146cellular response to nutrient (GO:0031670)2.35678524
147bone resorption (GO:0045453)2.35575296
148mammary gland alveolus development (GO:0060749)2.34227947
149signal complex assembly (GO:0007172)2.33729502
150mitotic G1 DNA damage checkpoint (GO:0031571)2.33501966
151negative regulation of fatty acid transport (GO:2000192)2.33303466
152cell-cell junction assembly (GO:0007043)2.33198357
153anterior/posterior axis specification, embryo (GO:0008595)2.33128928
154endocytic recycling (GO:0032456)2.32385590
155pentose-phosphate shunt (GO:0006098)2.32201357
156Golgi organization (GO:0007030)2.32122783
157membrane repolarization (GO:0086009)2.32058719
158negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.31715186
159positive regulation of nitric-oxide synthase activity (GO:0051000)2.31532067
160NLS-bearing protein import into nucleus (GO:0006607)2.31205837
161negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.31155439
162positive regulation of vesicle fusion (GO:0031340)2.30009786
163regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28929553
164protein targeting to Golgi (GO:0000042)2.28569159
165regulation of ARF GTPase activity (GO:0032312)2.28509866
166actin filament bundle assembly (GO:0051017)2.27923592
167actin filament bundle organization (GO:0061572)2.27923592
168regulation of tight junction assembly (GO:2000810)2.27706352
169plasma membrane repair (GO:0001778)2.27142635
170response to unfolded protein (GO:0006986)2.25765977
171negative regulation of nucleotide catabolic process (GO:0030812)2.25454781
172maintenance of protein localization in organelle (GO:0072595)2.24755777

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.80432110
2ESR1_20079471_ChIP-ChIP_T-47D_Human2.95433450
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81288857
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.74931944
5ZNF263_19887448_ChIP-Seq_K562_Human2.26307724
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22976717
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.22415225
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.19450613
9LXR_22292898_ChIP-Seq_THP-1_Human2.16828968
10RACK7_27058665_Chip-Seq_MCF-7_Human2.16203914
11MYC_22102868_ChIP-Seq_BL_Human2.14790229
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14410658
13ZFP281_18757296_ChIP-ChIP_E14_Mouse2.04396037
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.98478159
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.98478159
16KDM2B_26808549_Chip-Seq_K562_Human1.96821272
17ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.93746387
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92140778
19KDM2B_26808549_Chip-Seq_DND41_Human1.91221775
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87939094
21ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.86850697
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81978271
23CLOCK_20551151_ChIP-Seq_293T_Human1.80361040
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.80241331
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.77525646
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77379025
27ATF3_27146783_Chip-Seq_COLON_Human1.76934061
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74657215
29NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72593128
30GATA1_22025678_ChIP-Seq_K562_Human1.71930137
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.70954851
32TCF7_22412390_ChIP-Seq_EML_Mouse1.67996694
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67575498
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66635512
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.64723459
36NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64331735
37CREB1_26743006_Chip-Seq_LNCaP_Human1.64032730
38GATA3_24758297_ChIP-Seq_MCF-7_Human1.63266748
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60491717
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59202876
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58344520
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56811674
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.56591607
44* TFEB_21752829_ChIP-Seq_HELA_Human1.56342032
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55640005
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53963336
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.53478016
48SMC4_20622854_ChIP-Seq_HELA_Human1.50812181
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50538791
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.50220693
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.49932204
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49668260
53* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49080966
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48684003
55CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47535419
56P68_20966046_ChIP-Seq_HELA_Human1.46969767
57GATA1_19941826_ChIP-Seq_K562_Human1.46804675
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46048261
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46044929
60CHD1_26751641_Chip-Seq_LNCaP_Human1.45320610
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.44864224
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44843961
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43938987
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.43844198
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42805922
66CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41271390
67ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39857716
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39618623
69SOX2_20726797_ChIP-Seq_SW620_Human1.38996361
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.38939078
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.38364147
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37571015
73TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.36628438
74FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36535965
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36004500
76NCOR1_26117541_ChIP-Seq_K562_Human1.35566051
77DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35159028
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.34997293
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33571210
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32840371
81GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.32553068
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31346277
83HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30387340
84AR_21909140_ChIP-Seq_LNCAP_Human1.30375834
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30075663
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.29654551
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28289516
88EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.28222075
89KDM2B_26808549_Chip-Seq_JURKAT_Human1.27944913
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27760575
91* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26634576
92GATA6_25053715_ChIP-Seq_YYC3_Human1.26629958
93SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25730383
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24454496
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24207647
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23678785
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21916334
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21175737
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16877523
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16877523
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16877523
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16359540
103ELF5_23300383_ChIP-Seq_T47D_Human1.16197893
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16165157
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16025649
106LXR_22158963_ChIP-Seq_LIVER_Mouse1.15202383
107MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14414767
108KDM5A_27292631_Chip-Seq_BREAST_Human1.12754971
109AHR_22903824_ChIP-Seq_MCF-7_Human1.12568138
110SPI1_23127762_ChIP-Seq_K562_Human1.11921038
111TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.11311271
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11299721
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.11260117
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10936772
115VDR_21846776_ChIP-Seq_THP-1_Human1.10542643
116CDX2_20551321_ChIP-Seq_CACO-2_Human1.10423011
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10422862
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10152667
119FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10073821
120SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10039594
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09877169
122GATA1_19941827_ChIP-Seq_MEL_Mouse1.09313151
123BCOR_27268052_Chip-Seq_Bcells_Human1.09067286
124CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08946362
125KLF5_25053715_ChIP-Seq_YYC3_Human1.08701987
126TP63_22573176_ChIP-Seq_HFKS_Human1.08537641
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07823875
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07530156
129EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07133289
130* TET1_21490601_ChIP-Seq_MESCs_Mouse1.06826051
131STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06668386
132SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05837313
133NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05119193
134HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04438333
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04081190
136ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01496305
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98215093
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98110417
139NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97635454
140DCP1A_22483619_ChIP-Seq_HELA_Human0.95432394
141* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94849031
142* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93162558
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91962765
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90899515
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90560823
146CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88485629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation3.97672732
2MP0008961_abnormal_basal_metabolism3.58018662
3MP0010234_abnormal_vibrissa_follicle3.54748800
4MP0000579_abnormal_nail_morphology3.39767713
5MP0004264_abnormal_extraembryonic_tissu3.28843308
6MP0010678_abnormal_skin_adnexa3.11169601
7MP0003705_abnormal_hypodermis_morpholog3.00974498
8MP0003283_abnormal_digestive_organ2.93986943
9MP0004859_abnormal_synaptic_plasticity2.82547613
10MP0002909_abnormal_adrenal_gland2.73478081
11MP0004858_abnormal_nervous_system2.64278103
12MP0005058_abnormal_lysosome_morphology2.63076493
13MP0002877_abnormal_melanocyte_morpholog2.57597863
14MP0005409_darkened_coat_color2.43854821
15MP0003172_abnormal_lysosome_physiology2.38817797
16MP0005451_abnormal_body_composition2.30846533
17MP0002098_abnormal_vibrissa_morphology2.28895781
18MP0005501_abnormal_skin_physiology2.26560210
19MP0003941_abnormal_skin_development2.20426875
20MP0009840_abnormal_foam_cell2.15158695
21MP0002060_abnormal_skin_morphology2.13274817
22MP0003300_gastrointestinal_ulcer2.11566183
23MP0010352_gastrointestinal_tract_polyps2.10508870
24MP0004381_abnormal_hair_follicle2.08382636
25MP0001216_abnormal_epidermal_layer2.07935816
26MP0009780_abnormal_chondrocyte_physiolo2.07360121
27MP0003566_abnormal_cell_adhesion2.00297078
28MP0001765_abnormal_ion_homeostasis1.95678562
29MP0000013_abnormal_adipose_tissue1.95480327
30MP0001756_abnormal_urination1.92514157
31MP0009643_abnormal_urine_homeostasis1.86880140
32MP0000377_abnormal_hair_follicle1.82924460
33MP0000383_abnormal_hair_follicle1.80487812
34MP0004185_abnormal_adipocyte_glucose1.78723223
35MP0002653_abnormal_ependyma_morphology1.78390855
36MP0000627_abnormal_mammary_gland1.72982011
37MP0008260_abnormal_autophagy1.72546474
38MP0005076_abnormal_cell_differentiation1.69272869
39MP0005408_hypopigmentation1.66407073
40MP0003329_amyloid_beta_deposits1.64290223
41MP0001849_ear_inflammation1.62256815
42MP0005248_abnormal_Harderian_gland1.60751229
43MP0000467_abnormal_esophagus_morphology1.58861949
44MP0000003_abnormal_adipose_tissue1.57674123
45MP0010771_integument_phenotype1.54687895
46MP0003045_fibrosis1.53959628
47MP0004782_abnormal_surfactant_physiolog1.52573121
48MP0000427_abnormal_hair_cycle1.47582311
49MP0000678_abnormal_parathyroid_gland1.45181981
50MP0004885_abnormal_endolymph1.44697627
51MP0001881_abnormal_mammary_gland1.41202368
52MP0002254_reproductive_system_inflammat1.41063237
53MP0003075_altered_response_to1.38812985
54MP0005310_abnormal_salivary_gland1.38156898
55MP0000462_abnormal_digestive_system1.36952807
56MP0004019_abnormal_vitamin_homeostasis1.34923408
57MP0005332_abnormal_amino_acid1.34445675
58MP0002269_muscular_atrophy1.30455093
59MP0000762_abnormal_tongue_morphology1.29221641
60MP0001346_abnormal_lacrimal_gland1.28862327
61MP0003183_abnormal_peptide_metabolism1.26910234
62MP0005375_adipose_tissue_phenotype1.26496672
63MP0004233_abnormal_muscle_weight1.25734672
64MP0000537_abnormal_urethra_morphology1.21416022
65MP0005666_abnormal_adipose_tissue1.19693120
66MP0001727_abnormal_embryo_implantation1.18386761
67MP0003195_calcinosis1.14496625
68MP0002136_abnormal_kidney_physiology1.13444079
69MP0003656_abnormal_erythrocyte_physiolo1.13161925
70MP0001944_abnormal_pancreas_morphology1.12213125
71MP0003191_abnormal_cellular_cholesterol1.11170015
72MP0001666_abnormal_nutrient_absorption1.08714722
73MP0004084_abnormal_cardiac_muscle1.08218252
74MP0005167_abnormal_blood-brain_barrier1.07747727
75MP0004130_abnormal_muscle_cell1.05088398
76MP0002078_abnormal_glucose_homeostasis1.02744794
77MP0000367_abnormal_coat/_hair1.00801337
78MP0000747_muscle_weakness1.00591127
79MP0010307_abnormal_tumor_latency1.00338619
80MP0000604_amyloidosis0.98902227
81MP0009931_abnormal_skin_appearance0.98652705
82MP0002234_abnormal_pharynx_morphology0.98120352
83MP0001348_abnormal_lacrimal_gland0.97681329
84MP0005636_abnormal_mineral_homeostasis0.97510994
85MP0004270_analgesia0.97013247
86MP0004947_skin_inflammation0.95778689
87MP0002086_abnormal_extraembryonic_tissu0.94509661
88MP0001958_emphysema0.93157663
89MP0003123_paternal_imprinting0.92761374
90MP0002896_abnormal_bone_mineralization0.90747981
91MP0005670_abnormal_white_adipose0.90268940
92MP0005257_abnormal_intraocular_pressure0.88273780
93MP0005075_abnormal_melanosome_morpholog0.86542417
94MP0001730_embryonic_growth_arrest0.86361837
95MP0002693_abnormal_pancreas_physiology0.86282502
96MP0003011_delayed_dark_adaptation0.85626186
97MP0003890_abnormal_embryonic-extraembry0.84141602
98MP0005360_urolithiasis0.83456050
99MP0006035_abnormal_mitochondrial_morpho0.83318493
100MP0000566_synostosis0.83109954
101MP0003119_abnormal_digestive_system0.82613070
102MP0000015_abnormal_ear_pigmentation0.80157584
103MP0005319_abnormal_enzyme/_coenzyme0.79963224
104MP0005379_endocrine/exocrine_gland_phen0.79413872
105MP0003091_abnormal_cell_migration0.79231090
106MP0003984_embryonic_growth_retardation0.78968939
107MP0002088_abnormal_embryonic_growth/wei0.78094643
108MP0005023_abnormal_wound_healing0.76992772
109MP0003303_peritoneal_inflammation0.76890850
110MP0005623_abnormal_meninges_morphology0.76828391
111MP0000609_abnormal_liver_physiology0.76512100
112MP0001672_abnormal_embryogenesis/_devel0.76109323
113MP0005380_embryogenesis_phenotype0.76109323
114MP0005621_abnormal_cell_physiology0.74421947
115MP0009672_abnormal_birth_weight0.71459461
116MP0002090_abnormal_vision0.70678637
117MP0002118_abnormal_lipid_homeostasis0.70648551
118MP0003635_abnormal_synaptic_transmissio0.70455487
119MP0000358_abnormal_cell_content/0.70351143
120MP0003879_abnormal_hair_cell0.70112598
121MP0005083_abnormal_biliary_tract0.69834975
122MP0002796_impaired_skin_barrier0.68813607
123MP0002138_abnormal_hepatobiliary_system0.68801786
124MP0005377_hearing/vestibular/ear_phenot0.68492901
125MP0003878_abnormal_ear_physiology0.68492901
126MP0001191_abnormal_skin_condition0.67963796
127MP0002089_abnormal_postnatal_growth/wei0.67826941
128MP0003953_abnormal_hormone_level0.66196687
129MP0004272_abnormal_basement_membrane0.66098724
130MP0002168_other_aberrant_phenotype0.65985758
131MP0003453_abnormal_keratinocyte_physiol0.65610654
132MP0000647_abnormal_sebaceous_gland0.65120081
133MP0001873_stomach_inflammation0.65100903
134MP0002084_abnormal_developmental_patter0.64486281
135MP0002080_prenatal_lethality0.63027243
136MP0000858_altered_metastatic_potential0.62830000
137MP0003252_abnormal_bile_duct0.62181627
138MP0005220_abnormal_exocrine_pancreas0.62143645
139MP0010329_abnormal_lipoprotein_level0.61900358
140MP0002970_abnormal_white_adipose0.60344355
141MP0004087_abnormal_muscle_fiber0.60215185
142MP0002837_dystrophic_cardiac_calcinosis0.59820513
143MP0001697_abnormal_embryo_size0.59609891
144MP0005384_cellular_phenotype0.58149967
145MP0005365_abnormal_bile_salt0.58130691
146MP0000350_abnormal_cell_proliferation0.55593430
147MP0008874_decreased_physiological_sensi0.54488380
148MP0005165_increased_susceptibility_to0.54141571
149MP0003634_abnormal_glial_cell0.53859081
150MP0003943_abnormal_hepatobiliary_system0.50308190
151MP0008875_abnormal_xenobiotic_pharmacok0.49776315
152MP0003936_abnormal_reproductive_system0.49053474

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.75349797
2Gout (HP:0001997)4.61754976
3Hyperactive renin-angiotensin system (HP:0000841)3.72381576
4Onycholysis (HP:0001806)3.70789518
5Milia (HP:0001056)3.62229190
6Plantar hyperkeratosis (HP:0007556)3.47309979
7Hand muscle atrophy (HP:0009130)3.40913325
8Fragile nails (HP:0001808)3.37257918
9Abnormality of nail color (HP:0100643)3.34362471
10Abnormality of the lower motor neuron (HP:0002366)3.33620292
11Septate vagina (HP:0001153)3.29019144
12Abnormal hair laboratory examination (HP:0003328)3.25017222
13Distal upper limb amyotrophy (HP:0007149)3.24528730
14Upper limb amyotrophy (HP:0009129)3.24528730
15Hyperinsulinemic hypoglycemia (HP:0000825)3.15818834
16Hypokinesia (HP:0002375)3.13748907
17Urinary glycosaminoglycan excretion (HP:0003541)3.13486541
18Mucopolysacchariduria (HP:0008155)3.13486541
19Abnormality of chloride homeostasis (HP:0011422)3.00017504
20Increased circulating renin level (HP:0000848)2.99786707
21Abnormality of mucopolysaccharide metabolism (HP:0011020)2.91960831
22Abnormality of polysaccharide metabolism (HP:0011012)2.91960831
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.91960831
24Global brain atrophy (HP:0002283)2.90117244
25Dysostosis multiplex (HP:0000943)2.87888540
26Resting tremor (HP:0002322)2.86435817
27Hypokalemic alkalosis (HP:0001949)2.80677569
28Nail dystrophy (HP:0008404)2.76648545
29Increased cerebral lipofuscin (HP:0011813)2.75001287
30Micronodular cirrhosis (HP:0001413)2.74179021
31Cerebral aneurysm (HP:0004944)2.72660254
32Ketoacidosis (HP:0001993)2.71653350
33Supranuclear gaze palsy (HP:0000605)2.69672743
34Growth hormone excess (HP:0000845)2.69514774
35Lip pit (HP:0100267)2.62555459
36Renal salt wasting (HP:0000127)2.60893490
37Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56833014
38Atrophic scars (HP:0001075)2.56534402
39Palmoplantar hyperkeratosis (HP:0000972)2.55453582
40Alopecia of scalp (HP:0002293)2.54404420
41Thick nail (HP:0001805)2.52472646
42Insidious onset (HP:0003587)2.50374932
43Termporal pattern (HP:0011008)2.50374932
44Increased purine levels (HP:0004368)2.45054516
45Hyperuricemia (HP:0002149)2.45054516
46Hyperparathyroidism (HP:0000843)2.42412859
47Selective tooth agenesis (HP:0001592)2.38209676
48Sparse eyelashes (HP:0000653)2.36351372
49Metabolic alkalosis (HP:0200114)2.33793623
50Bundle branch block (HP:0011710)2.33328060
51Abnormality of renin-angiotensin system (HP:0000847)2.29815400
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29594398
53Palmar hyperkeratosis (HP:0010765)2.27957130
54Advanced eruption of teeth (HP:0006288)2.27611214
55Loss of speech (HP:0002371)2.26646253
56Apathy (HP:0000741)2.24719274
57Hypoplasia of dental enamel (HP:0006297)2.23881402
58Hyperaldosteronism (HP:0000859)2.23494857
59Unilateral renal agenesis (HP:0000122)2.23395695
60Abnormality of purine metabolism (HP:0004352)2.22344027
61Curly hair (HP:0002212)2.21584232
62Ankle clonus (HP:0011448)2.21202804
63Mitral stenosis (HP:0001718)2.20978291
64Hyperglycinuria (HP:0003108)2.20187815
65Distal lower limb muscle weakness (HP:0009053)2.19969936
66Symptomatic seizures (HP:0011145)2.19539556
67Neurofibrillary tangles (HP:0002185)2.19417771
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17535348
69Ventricular fibrillation (HP:0001663)2.16074657
70Asymmetry of the thorax (HP:0001555)2.15421341
71Achilles tendon contracture (HP:0001771)2.13693665
72J-shaped sella turcica (HP:0002680)2.12722524
73Ependymoma (HP:0002888)2.12378181
74Adrenal overactivity (HP:0002717)2.12134241
75Cervical subluxation (HP:0003308)2.11281356
76Congenital ichthyosiform erythroderma (HP:0007431)2.10014283
77Multiple enchondromatosis (HP:0005701)2.09819276
78Abnormality of the gastric mucosa (HP:0004295)2.09539646
79Ridged nail (HP:0001807)2.09001134
80Vascular calcification (HP:0004934)2.08006036
81Sparse lateral eyebrow (HP:0005338)2.07320894
82Hypoglycemic coma (HP:0001325)2.07300508
83Visual hallucinations (HP:0002367)2.07204045
84Diminished motivation (HP:0000745)2.06730765
85Abnormality of the distal phalanges of the toes (HP:0010182)2.06201275
86Abnormality of the Achilles tendon (HP:0005109)2.05767035
87Abnormal blistering of the skin (HP:0008066)2.03928802
88Autoamputation (HP:0001218)2.03712871
89Tetany (HP:0001281)2.03213300
90Aplasia cutis congenita (HP:0001057)2.02794580
91Abnormality of the salivary glands (HP:0010286)2.02324828
92Spinal muscular atrophy (HP:0007269)2.01780138
93Vertebral compression fractures (HP:0002953)2.01159539
94Hypercortisolism (HP:0001578)2.00773625
95Abnormality of glycolipid metabolism (HP:0010969)2.00637173
96Abnormality of liposaccharide metabolism (HP:0010968)2.00637173
97Abnormality of glycosphingolipid metabolism (HP:0004343)2.00637173
98Hypotrichosis (HP:0001006)1.99948235
99Progressive hearing impairment (HP:0001730)1.99505607
100Difficulty climbing stairs (HP:0003551)1.98048640
101Tongue fasciculations (HP:0001308)1.97470256
102Hypokalemia (HP:0002900)1.97046415
103Aneurysm (HP:0002617)1.96854244
104Abnormality of calcium-phosphate metabolism (HP:0100530)1.96444652
105Increased neuronal autofluorescent lipopigment (HP:0002074)1.95248313
106Increased CSF protein (HP:0002922)1.94447449
107Stridor (HP:0010307)1.93933738
108Diminished movement (HP:0002374)1.92621712
109Ankyloglossia (HP:0010296)1.92086027
110Overlapping toe (HP:0001845)1.91772600
111Turricephaly (HP:0000262)1.91508958
112Interstitial pulmonary disease (HP:0006530)1.91333479
113Testicular neoplasm (HP:0010788)1.90896666
114Trismus (HP:0000211)1.90751353
115Hypoglycemic seizures (HP:0002173)1.90700960
116Polycythemia (HP:0001901)1.90464505
117Polyuria (HP:0000103)1.90191027
118Abnormal gallbladder physiology (HP:0012438)1.89139975
119Cholecystitis (HP:0001082)1.89139975
120Insomnia (HP:0100785)1.88785653
121Hyperglycemia (HP:0003074)1.88569672
122Abnormal urine output (HP:0012590)1.88512607
123Mildly elevated creatine phosphokinase (HP:0008180)1.87543356
124Abdominal distention (HP:0003270)1.86048835
125Metaphyseal cupping (HP:0003021)1.85634536
126Broad face (HP:0000283)1.85430500
127Pterygium (HP:0001059)1.84727370
128Neonatal death (HP:0003811)1.83753788
129Neuronal loss in central nervous system (HP:0002529)1.82263560
130Progressive neurologic deterioration (HP:0002344)1.82173167
131Distal lower limb amyotrophy (HP:0008944)1.82160085
132Abnormality of the astrocytes (HP:0100707)1.81094205
133Astrocytoma (HP:0009592)1.81094205
134Abnormality of renal excretion (HP:0011036)1.80438476
135Hypotension (HP:0002615)1.80191249
136Abnormality of sodium homeostasis (HP:0010931)1.80072135
137Neoplasm of the heart (HP:0100544)1.79980650
138Rapidly progressive (HP:0003678)1.79491919
139Akinesia (HP:0002304)1.79126615
140Progressive muscle weakness (HP:0003323)1.78332102
141Testicular atrophy (HP:0000029)1.78066297
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78043770
143Ulnar bowing (HP:0003031)1.77874334
144Asymmetric septal hypertrophy (HP:0001670)1.76675878
145Spinal cord compression (HP:0002176)1.75836234
146Freckling (HP:0001480)1.75573874
147Cerebral inclusion bodies (HP:0100314)1.74690558
148Long palpebral fissure (HP:0000637)1.74408917
149Flat acetabular roof (HP:0003180)1.74400897
150Hyperphosphatemia (HP:0002905)1.74367449
151Macroorchidism (HP:0000053)1.73784640
152Abnormality of potassium homeostasis (HP:0011042)1.72599622
153Muscle fibrillation (HP:0010546)1.71925700
154Late onset (HP:0003584)1.70608350
155Hyperacusis (HP:0010780)1.70321766
156Tetraplegia (HP:0002445)1.69839608
157Hyperthyroidism (HP:0000836)1.69526541
158Hamartoma of the eye (HP:0010568)1.69453489
159Posterior subcapsular cataract (HP:0007787)1.69225539
160Subacute progressive viral hepatitis (HP:0006572)1.68851240
161Long toe (HP:0010511)1.68784905
162Abnormality of the pancreatic islet cells (HP:0006476)1.67723316
163Abnormality of endocrine pancreas physiology (HP:0012093)1.67723316
164Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67718354
165Dysmetric saccades (HP:0000641)1.66553011
166Increased connective tissue (HP:0009025)1.66488036
167Retinal atrophy (HP:0001105)1.66344132
168Ketosis (HP:0001946)1.65566247
169Malnutrition (HP:0004395)1.65490931
170Spastic tetraparesis (HP:0001285)1.65410955
171Hyponatremia (HP:0002902)1.65292412
172Insulin-resistant diabetes mellitus (HP:0000831)1.65055283
173Status epilepticus (HP:0002133)1.63949806
174Abnormal cartilage morphology (HP:0002763)1.61568542
175EMG: neuropathic changes (HP:0003445)1.61479905
176Severe short stature (HP:0003510)1.61153412
177Hypomagnesemia (HP:0002917)1.59742854
178Pili torti (HP:0003777)1.59279817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.21896839
2TRIB33.94595172
3ERN13.21191024
4MAP3K92.98348135
5PRKD32.97344744
6TESK12.81375377
7CDK122.54185817
8KSR22.39445221
9MAP3K122.37954086
10TRIM282.20280730
11TAOK12.08431806
12NEK12.01858647
13SIK31.98287868
14EPHA21.96090802
15NTRK11.89656554
16RIPK11.85229637
17WNK41.79887512
18PDGFRA1.78578522
19MAP3K21.77277732
20SCYL21.76948523
21EIF2AK11.72471794
22ALK1.71731413
23PKN21.71618132
24TYRO31.64945782
25SMG11.61839003
26MST41.57110562
27STK381.55767364
28WNK31.53753507
29DAPK21.53328831
30IRAK31.49331310
31PAK61.44736735
32EEF2K1.39458307
33GRK61.39196940
34PTK21.38583204
35CAMKK11.33223642
36GRK51.30750876
37LIMK11.26640898
38NEK61.26295225
39STK101.20929470
40LRRK21.20723025
41DDR21.18221540
42NME21.17770005
43PTK61.17662463
44LATS21.15915995
45PAK41.14198617
46PRKCH1.09180009
47WNK11.05602970
48BMX1.05310872
49RPS6KB21.04298357
50NTRK31.02220479
51PBK1.02110373
52ICK1.01278437
53SIK11.00090059
54PAK30.99487010
55YES10.98552232
56EPHA40.97992054
57MAP3K10.97388105
58PHKG20.93721900
59PHKG10.93721900
60LMTK20.93429219
61HIPK20.92401180
62PRKD20.91712258
63MTOR0.90080294
64FGFR30.89334099
65AKT30.88661296
66NME10.88311199
67DAPK10.87421389
68SGK30.84835873
69RET0.84575121
70MAP3K100.83942844
71STK240.83588158
72LATS10.83002182
73FER0.82268306
74MAP2K10.81066988
75PRPF4B0.80857011
76MAP3K70.80606397
77MAPKAPK30.79755433
78PDPK10.78158390
79PDK10.77521357
80TSSK60.74519056
81INSRR0.72388828
82OXSR10.70932437
83ILK0.70090433
84MATK0.68684680
85FGFR20.68506652
86PDK40.68351637
87PDK30.68351637
88CDC42BPA0.68011101
89MARK20.66695604
90ERBB40.64822914
91TTN0.62941328
92JAK20.62149995
93PRKAA10.60937060
94PINK10.59705639
95TAOK30.59642223
96PRKCI0.59425156
97CAMK2G0.59046470
98PRKG20.58902564
99DMPK0.57976332
100BRSK10.56427297
101PDGFRB0.56143902
102TGFBR20.55866073
103CDK70.55569730
104DYRK1B0.55287010
105MAP3K80.55016547
106BCKDK0.54135037
107ARAF0.53560476
108PDK20.52130189
109MAP3K30.51852984
110TESK20.50625883
111MAP3K130.50394331
112MAP3K110.50060970
113CAMK2B0.48924338
114ROCK20.47955259
115GSK3A0.47751944
116EPHB10.47595200
117AKT20.46951296
118MET0.46547835
119FGFR40.46536142
120CDK50.46151137
121PRKD10.45963494
122RAF10.43409026
123PASK0.43168670
124MAP2K20.43048826
125MAPK150.42638001
126STK38L0.41308326
127STK110.40691883
128CAMK2D0.40539057
129ERBB30.40478423
130FLT30.39696809
131CAMK40.39308960
132DAPK30.39124487
133TTK0.38997209
134BMPR20.38418305
135KSR10.38208083
136JAK10.37805794
137PIK3CA0.36644242
138BRD40.36622758
139TBK10.34731532
140EPHA30.33064293
141RPS6KA20.32983850
142CDK90.32281765
143RPS6KB10.31903588
144BRAF0.30178683

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.83498538
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.63408271
3Nitrogen metabolism_Homo sapiens_hsa009102.63216727
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.23616108
5Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.01019676
6Synaptic vesicle cycle_Homo sapiens_hsa047211.93483387
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.92458813
8mTOR signaling pathway_Homo sapiens_hsa041501.88163493
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.87013991
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71875083
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.71481642
12Lysosome_Homo sapiens_hsa041421.71275137
13Insulin secretion_Homo sapiens_hsa049111.69071575
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.54578720
15Sphingolipid metabolism_Homo sapiens_hsa006001.54051395
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.51155611
17Fructose and mannose metabolism_Homo sapiens_hsa000511.49116998
18Gastric acid secretion_Homo sapiens_hsa049711.43022461
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41300849
20Vitamin B6 metabolism_Homo sapiens_hsa007501.41015691
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40928894
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39438768
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37309625
24Thyroid hormone synthesis_Homo sapiens_hsa049181.35984357
25Type II diabetes mellitus_Homo sapiens_hsa049301.34726488
26Long-term potentiation_Homo sapiens_hsa047201.31124292
27N-Glycan biosynthesis_Homo sapiens_hsa005101.30846728
28Bile secretion_Homo sapiens_hsa049761.30535167
29Fatty acid elongation_Homo sapiens_hsa000621.27782642
30Collecting duct acid secretion_Homo sapiens_hsa049661.24510352
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17623756
32Sulfur metabolism_Homo sapiens_hsa009201.17556536
33Hepatitis C_Homo sapiens_hsa051601.16991270
34Glioma_Homo sapiens_hsa052141.14763233
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14400732
36Bladder cancer_Homo sapiens_hsa052191.11391331
37Folate biosynthesis_Homo sapiens_hsa007901.07654808
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05898107
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05471969
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04709250
41Insulin resistance_Homo sapiens_hsa049311.03089668
42Salivary secretion_Homo sapiens_hsa049701.01539808
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01409612
44VEGF signaling pathway_Homo sapiens_hsa043700.99755991
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.99179293
46Estrogen signaling pathway_Homo sapiens_hsa049150.95241073
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94688305
48Mineral absorption_Homo sapiens_hsa049780.94148306
49Steroid biosynthesis_Homo sapiens_hsa001000.92150555
50Central carbon metabolism in cancer_Homo sapiens_hsa052300.90580562
51Endocytosis_Homo sapiens_hsa041440.90526798
52Vibrio cholerae infection_Homo sapiens_hsa051100.89775228
53GnRH signaling pathway_Homo sapiens_hsa049120.89270100
54* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88641486
55Amphetamine addiction_Homo sapiens_hsa050310.87032328
56Phenylalanine metabolism_Homo sapiens_hsa003600.86258528
57Galactose metabolism_Homo sapiens_hsa000520.85970357
58Biosynthesis of amino acids_Homo sapiens_hsa012300.85549280
59Arginine biosynthesis_Homo sapiens_hsa002200.84816899
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83209377
61Fatty acid biosynthesis_Homo sapiens_hsa000610.83029112
62Pancreatic secretion_Homo sapiens_hsa049720.82858004
63Carbon metabolism_Homo sapiens_hsa012000.82491884
64AMPK signaling pathway_Homo sapiens_hsa041520.82295270
65Glucagon signaling pathway_Homo sapiens_hsa049220.81001867
66Non-small cell lung cancer_Homo sapiens_hsa052230.80759628
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.78898053
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.78557694
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.76248969
70* Inositol phosphate metabolism_Homo sapiens_hsa005620.76234416
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75406276
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75331799
73Insulin signaling pathway_Homo sapiens_hsa049100.75225115
74Acute myeloid leukemia_Homo sapiens_hsa052210.74775150
75Endometrial cancer_Homo sapiens_hsa052130.74515345
76Dorso-ventral axis formation_Homo sapiens_hsa043200.73227234
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.72483390
78Choline metabolism in cancer_Homo sapiens_hsa052310.72309401
79Small cell lung cancer_Homo sapiens_hsa052220.70220029
80Proteoglycans in cancer_Homo sapiens_hsa052050.70015950
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69955090
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.68260664
83Chronic myeloid leukemia_Homo sapiens_hsa052200.68192188
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68185849
85Circadian entrainment_Homo sapiens_hsa047130.66878189
86Glycerolipid metabolism_Homo sapiens_hsa005610.66748313
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66227004
88Oxytocin signaling pathway_Homo sapiens_hsa049210.66181648
89Oocyte meiosis_Homo sapiens_hsa041140.66096302
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.65767414
91Protein digestion and absorption_Homo sapiens_hsa049740.65624668
92Prostate cancer_Homo sapiens_hsa052150.64639301
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64339506
94Proteasome_Homo sapiens_hsa030500.64299212
95Phototransduction_Homo sapiens_hsa047440.63875400
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63397910
97Dopaminergic synapse_Homo sapiens_hsa047280.63339282
98Thyroid cancer_Homo sapiens_hsa052160.63252349
99Tight junction_Homo sapiens_hsa045300.61869308
100Olfactory transduction_Homo sapiens_hsa047400.61844996
101Circadian rhythm_Homo sapiens_hsa047100.61679840
102Other glycan degradation_Homo sapiens_hsa005110.61499470
103GABAergic synapse_Homo sapiens_hsa047270.61365003
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.61048448
105Lysine degradation_Homo sapiens_hsa003100.59558518
106Shigellosis_Homo sapiens_hsa051310.59296551
107Gap junction_Homo sapiens_hsa045400.58556100
108Focal adhesion_Homo sapiens_hsa045100.58342862
109Fatty acid degradation_Homo sapiens_hsa000710.57984232
110Renal cell carcinoma_Homo sapiens_hsa052110.56658813
111HIF-1 signaling pathway_Homo sapiens_hsa040660.56187891
112ErbB signaling pathway_Homo sapiens_hsa040120.55997682
113Pentose phosphate pathway_Homo sapiens_hsa000300.55500602
114Adherens junction_Homo sapiens_hsa045200.54577996
115Selenocompound metabolism_Homo sapiens_hsa004500.53613238
116Cholinergic synapse_Homo sapiens_hsa047250.53338869
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52647993
118Pancreatic cancer_Homo sapiens_hsa052120.51325372
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51125347
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51120139
121Vitamin digestion and absorption_Homo sapiens_hsa049770.50484550
122Fatty acid metabolism_Homo sapiens_hsa012120.50424524
123Prolactin signaling pathway_Homo sapiens_hsa049170.50407410
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50394696
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.49643302
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49577297
127Glutathione metabolism_Homo sapiens_hsa004800.44197358
128Prion diseases_Homo sapiens_hsa050200.44027117
129Arginine and proline metabolism_Homo sapiens_hsa003300.39111946
130Starch and sucrose metabolism_Homo sapiens_hsa005000.37631247

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