PIP5K1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.37005020
2detection of calcium ion (GO:0005513)4.96406222
3protoporphyrinogen IX biosynthetic process (GO:0006782)4.47443462
4nerve growth factor signaling pathway (GO:0038180)4.20064191
5gas transport (GO:0015669)4.05736125
6positive regulation of Cdc42 GTPase activity (GO:0043089)4.05675247
7vocalization behavior (GO:0071625)3.93806990
8lipoprotein transport (GO:0042953)3.91970228
9porphyrin-containing compound biosynthetic process (GO:0006779)3.83762093
10regulation of guanylate cyclase activity (GO:0031282)3.81891675
11thrombin receptor signaling pathway (GO:0070493)3.72200517
12regulation of dendritic cell antigen processing and presentation (GO:0002604)3.66423388
13NADH metabolic process (GO:0006734)3.62070861
14membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.57316585
15membrane repolarization during action potential (GO:0086011)3.51996201
16photoreceptor cell differentiation (GO:0046530)3.45111990
17eye photoreceptor cell differentiation (GO:0001754)3.45111990
18glycine transport (GO:0015816)3.44983008
19very-low-density lipoprotein particle assembly (GO:0034379)3.44843889
20ER overload response (GO:0006983)3.39403136
21positive regulation of action potential (GO:0045760)3.38301269
22tetrapyrrole biosynthetic process (GO:0033014)3.34860209
23angiotensin maturation (GO:0002003)3.34129580
24endocrine pancreas development (GO:0031018)3.31948161
25sodium ion export (GO:0071436)3.31652249
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31193274
27regulation of mitochondrial depolarization (GO:0051900)3.29659236
28positive regulation of glycoprotein biosynthetic process (GO:0010560)3.29632176
29cytidine metabolic process (GO:0046087)3.26853763
30cytidine catabolic process (GO:0006216)3.26853763
31cytidine deamination (GO:0009972)3.26853763
32glomerular basement membrane development (GO:0032836)3.26700547
33cGMP-mediated signaling (GO:0019934)3.25949684
34peptide hormone processing (GO:0016486)3.22933682
35intestinal absorption (GO:0050892)3.21546836
36hemoglobin metabolic process (GO:0020027)3.21386305
37positive regulation of Rap GTPase activity (GO:0032854)3.21208868
38relaxation of cardiac muscle (GO:0055119)3.20371513
39regulation of B cell receptor signaling pathway (GO:0050855)3.18530663
40positive regulation of B cell differentiation (GO:0045579)3.17213875
41regulation of platelet aggregation (GO:0090330)3.14596896
42regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.11559329
43negative regulation of dendrite morphogenesis (GO:0050774)3.10922643
44skeletal muscle adaptation (GO:0043501)3.05961534
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05802712
46bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04019575
47insulin secretion (GO:0030073)3.03859423
48cellular response to epinephrine stimulus (GO:0071872)3.03636004
49negative regulation of erythrocyte differentiation (GO:0045647)3.01217232
50response to epinephrine (GO:0071871)2.99711776
51ventricular cardiac muscle cell action potential (GO:0086005)2.99061971
52neuronal action potential propagation (GO:0019227)2.98273915
53heme biosynthetic process (GO:0006783)2.95514549
54porphyrin-containing compound metabolic process (GO:0006778)2.94657215
55regulation of female receptivity (GO:0045924)2.94565519
56pyrimidine ribonucleoside catabolic process (GO:0046133)2.93681195
57positive regulation of guanylate cyclase activity (GO:0031284)2.93008553
58cellular response to reactive nitrogen species (GO:1902170)2.92240109
59B cell receptor signaling pathway (GO:0050853)2.90745524
60positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89192418
61Golgi transport vesicle coating (GO:0048200)2.88783914
62COPI coating of Golgi vesicle (GO:0048205)2.88783914
63regulation of bile acid biosynthetic process (GO:0070857)2.87925854
64antibacterial humoral response (GO:0019731)2.87054180
65phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.83704452
66regulation of T-helper 1 cell differentiation (GO:0045625)2.83659299
67cardiac conduction (GO:0061337)2.83264971
68sequestering of metal ion (GO:0051238)2.83250410
69striated muscle hypertrophy (GO:0014897)2.82436179
70oxygen transport (GO:0015671)2.82208103
71erythrocyte development (GO:0048821)2.80603132
72regulation of protein glycosylation (GO:0060049)2.79817819
73protein maturation by protein folding (GO:0022417)2.78681626
74protein localization to Golgi apparatus (GO:0034067)2.77786844
75positive regulation of gamma-delta T cell activation (GO:0046645)2.77711980
76peptide catabolic process (GO:0043171)2.77011730
77neuron cell-cell adhesion (GO:0007158)2.76091227
78mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75180829
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75066516
80regulation of Rap GTPase activity (GO:0032317)2.74990946
81cell communication involved in cardiac conduction (GO:0086065)2.74879463
82glandular epithelial cell differentiation (GO:0002067)2.73149546
83regulation of action potential (GO:0098900)2.71457556
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.70789840
85cellular sodium ion homeostasis (GO:0006883)2.70495766
86regulation of heart rate by cardiac conduction (GO:0086091)2.70445727
87response to nitric oxide (GO:0071731)2.69625226
88protein targeting to Golgi (GO:0000042)2.69622743
89multicellular organismal signaling (GO:0035637)2.69322178
90regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.68347269
91regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67650500
92positive regulation of glycoprotein metabolic process (GO:1903020)2.66728599
93plasma lipoprotein particle assembly (GO:0034377)2.65063364
94response to insecticide (GO:0017085)2.64961793
95regulation of clathrin-mediated endocytosis (GO:2000369)2.63728232
96phospholipid scrambling (GO:0017121)2.63375990
97definitive hemopoiesis (GO:0060216)2.63347791
98ionotropic glutamate receptor signaling pathway (GO:0035235)2.62442874
99otic vesicle formation (GO:0030916)2.61786643
100L-fucose catabolic process (GO:0042355)2.61097947
101fucose catabolic process (GO:0019317)2.61097947
102L-fucose metabolic process (GO:0042354)2.61097947
103antimicrobial humoral response (GO:0019730)2.60668177
104cellular potassium ion homeostasis (GO:0030007)2.60618960
105detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.60405458
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.60213227
107regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60126526
108synaptic vesicle maturation (GO:0016188)2.59780044
109sodium ion homeostasis (GO:0055078)2.59303648
110sensory perception of taste (GO:0050909)2.58946181
111gonadal mesoderm development (GO:0007506)2.58079700
112positive regulation of antigen processing and presentation (GO:0002579)2.57971306
113muscle atrophy (GO:0014889)2.57378273
114regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.57337141
115synaptic vesicle exocytosis (GO:0016079)2.56742162
116locomotory exploration behavior (GO:0035641)2.56294446
117regulation of actin filament-based movement (GO:1903115)2.54801968
118fucose metabolic process (GO:0006004)2.54690233
119dendritic cell chemotaxis (GO:0002407)2.54682379
120female mating behavior (GO:0060180)2.54653439
121phosphatidylserine acyl-chain remodeling (GO:0036150)2.53816114
122receptor guanylyl cyclase signaling pathway (GO:0007168)2.52386529
123regulation of synapse maturation (GO:0090128)2.52099662
124regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52012754
125muscle hypertrophy (GO:0014896)2.51951807
126cGMP biosynthetic process (GO:0006182)2.51816558
127regulation of cell communication by electrical coupling (GO:0010649)2.50991644
128transmission of nerve impulse (GO:0019226)2.50748355
129positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.50084968
130bicarbonate transport (GO:0015701)2.49659249
131regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48551961
132phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.48345725
133neurotransmitter catabolic process (GO:0042135)2.47711378
134positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.47305556
135cellular response to hepatocyte growth factor stimulus (GO:0035729)2.47160826
136response to hepatocyte growth factor (GO:0035728)2.47160826
137membrane repolarization (GO:0086009)2.45866471
138surfactant homeostasis (GO:0043129)2.45676598
139regulation of synaptic vesicle exocytosis (GO:2000300)2.45366031
140fucosylation (GO:0036065)2.45295466
141short-chain fatty acid metabolic process (GO:0046459)2.45248027
142myeloid cell development (GO:0061515)2.45127220
143nucleoside diphosphate biosynthetic process (GO:0009133)2.45106518
144neuron recognition (GO:0008038)2.44305865
145regulation of type B pancreatic cell apoptotic process (GO:2000674)2.44069936
146Rap protein signal transduction (GO:0032486)2.43710385
147potassium ion import (GO:0010107)2.43527433
148regulation of insulin secretion (GO:0050796)2.42682959
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.41705151
150inositol phosphate dephosphorylation (GO:0046855)2.41705151
151glomerular filtration (GO:0003094)2.41656420
152presynaptic membrane assembly (GO:0097105)2.41308413
153glutamate receptor signaling pathway (GO:0007215)2.40632421
154response to monoamine (GO:0071867)2.39645480
155response to catecholamine (GO:0071869)2.39645480
156growth hormone secretion (GO:0030252)2.39630546
157positive regulation of DNA-templated transcription, initiation (GO:2000144)2.39097681
158regulation of cardiac muscle cell contraction (GO:0086004)2.38120639
159sperm capacitation (GO:0048240)2.38042017
160cellular response to nitric oxide (GO:0071732)2.37820024
161interkinetic nuclear migration (GO:0022027)2.37248040
162succinate metabolic process (GO:0006105)2.36328819
163respiratory electron transport chain (GO:0022904)2.36290763
164maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35699926
165cell communication by electrical coupling (GO:0010644)2.35687526
166signal peptide processing (GO:0006465)2.35601376
167labyrinthine layer development (GO:0060711)2.35356384
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.34890129
169catechol-containing compound biosynthetic process (GO:0009713)2.34840144
170catecholamine biosynthetic process (GO:0042423)2.34840144
171calcium ion import (GO:0070509)2.34582069
172transepithelial transport (GO:0070633)2.34443206
173inositol phosphate catabolic process (GO:0071545)2.34123437
174regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.33917883
175immunoglobulin mediated immune response (GO:0016064)2.33901728
176regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.33820141
177adrenergic receptor signaling pathway (GO:0071875)2.33580704
178one-carbon compound transport (GO:0019755)2.33491223
179neuronal ion channel clustering (GO:0045161)2.33411375
180regulation of RIG-I signaling pathway (GO:0039535)2.33279900
181regulation of synaptic vesicle transport (GO:1902803)2.33076673
182peptide hormone secretion (GO:0030072)2.32622970
183negative regulation of norepinephrine secretion (GO:0010700)2.32410371
184regulation of oxidative phosphorylation (GO:0002082)2.31863289
185negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.31618672
186relaxation of muscle (GO:0090075)2.31181088
187potassium ion export (GO:0071435)2.31078769
188regulation of cholesterol homeostasis (GO:2000188)2.30906646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.82303146
2GBX2_23144817_ChIP-Seq_PC3_Human3.58835213
3SCL_19346495_ChIP-Seq_HPC-7_Human3.53036270
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.50545679
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.26512109
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.11156667
7GATA1_22025678_ChIP-Seq_K562_Human2.92924918
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69460168
9* GATA2_19941826_ChIP-Seq_K562_Human2.68268949
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67699804
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53211972
12VDR_22108803_ChIP-Seq_LS180_Human2.48898472
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37402243
14DROSHA_22980978_ChIP-Seq_HELA_Human2.34778565
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.30861655
16IGF1R_20145208_ChIP-Seq_DFB_Human2.30200090
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18949970
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17881889
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15923931
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14664516
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12015392
22* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.09898437
23* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.07856986
24* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.06863991
25* GATA1_19941827_ChIP-Seq_MEL_Mouse2.06334099
26* REST_21632747_ChIP-Seq_MESCs_Mouse2.01913996
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.92727847
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.92588035
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.91110276
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.91110276
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86738707
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85185000
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.83975235
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.77541096
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77246124
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72044941
37ZNF274_21170338_ChIP-Seq_K562_Hela1.70955906
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.69984729
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69593397
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69554308
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69021896
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68573422
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.68513214
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.67816568
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.64945728
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63423744
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.62470140
48TAF15_26573619_Chip-Seq_HEK293_Human1.61299371
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60955928
50* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58500159
51RUNX_20019798_ChIP-Seq_JUKART_Human1.58457032
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55269039
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.55140284
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.51194563
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50619090
56MYB_26560356_Chip-Seq_TH2_Human1.49362308
57CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47882523
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.47252306
59STAT3_23295773_ChIP-Seq_U87_Human1.47209293
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.47063271
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46896933
62IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46840552
63ER_23166858_ChIP-Seq_MCF-7_Human1.45293827
64P300_19829295_ChIP-Seq_ESCs_Human1.44268691
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43868829
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.43047674
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38963841
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38830343
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37884518
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.36806810
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36417613
72FUS_26573619_Chip-Seq_HEK293_Human1.34874218
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34426473
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32753054
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32541987
76OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29100244
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.29099504
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28677712
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26915129
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26639007
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25953754
82* TCF4_23295773_ChIP-Seq_U87_Human1.25564820
83* GATA4_25053715_ChIP-Seq_YYC3_Human1.25397879
84* SALL4_22934838_ChIP-ChIP_CD34+_Human1.24988853
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23628923
86* CDX2_22108803_ChIP-Seq_LS180_Human1.22897717
87SPI1_23127762_ChIP-Seq_K562_Human1.22702645
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20996047
89* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19888108
90AR_25329375_ChIP-Seq_VCAP_Human1.19822705
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19511646
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19361816
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.19114013
94ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18747036
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.18316528
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16899548
97SMRT_27268052_Chip-Seq_Bcells_Human1.16255670
98* GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14166241
99CEBPB_22108803_ChIP-Seq_LS180_Human1.13941265
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13060510
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12558558
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.12040775
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11123219
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.10958902
105BCAT_22108803_ChIP-Seq_LS180_Human1.10539655
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09714365
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09600918
108GATA1_19941826_ChIP-Seq_K562_Human1.09015580
109* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08874338
110P53_22387025_ChIP-Seq_ESCs_Mouse1.08157396
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.08035148
112RUNX2_22187159_ChIP-Seq_PCA_Human1.07875636
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07741219
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.07431675
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07006585
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.06892539
117ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06780476
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06168740
119EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05192768
120EP300_21415370_ChIP-Seq_HL-1_Mouse1.04629937
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04472774
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04289105
123E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03707822
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03541171
125GATA3_27048872_Chip-Seq_THYMUS_Human1.03304901
126NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03085904
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.02729870
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02377437
129FLI1_27457419_Chip-Seq_LIVER_Mouse1.02309156
130SOX2_18555785_Chip-Seq_ESCs_Mouse1.02102281
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00694356
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.99845119
133AR_19668381_ChIP-Seq_PC3_Human0.99460820
134AHR_22903824_ChIP-Seq_MCF-7_Human0.99123120
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98398527
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97075096
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96967772
138RNF2_27304074_Chip-Seq_NSC_Mouse0.96610669
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96030534
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95780105
141* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95041260
142CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94787125
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94653922
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94623832
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94449312
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94217640
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94175553
148TP53_16413492_ChIP-PET_HCT116_Human0.93867337
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.93693602
150PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93601966
151IRF8_27001747_Chip-Seq_BMDM_Mouse0.93120018
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93091039
153YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93021516
154SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92923175
155CMYC_18555785_Chip-Seq_ESCs_Mouse0.92716207
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92308603
157IRF8_21731497_ChIP-ChIP_J774_Mouse0.92237075
158CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90676224
159* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90114185
160GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89751538
161VDR_24787735_ChIP-Seq_THP-1_Human0.87950849
162STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87042227
163* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86890059
164ETV1_20927104_ChIP-Seq_GIST48_Human0.84903090
165PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84862193
166STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.84794489
167NANOG_19829295_ChIP-Seq_ESCs_Human0.84783445
168SOX2_19829295_ChIP-Seq_ESCs_Human0.84783445
169FOXA1_25552417_ChIP-Seq_VCAP_Human0.84006010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology3.99146631
2MP0005377_hearing/vestibular/ear_phenot3.99146631
3MP0003656_abnormal_erythrocyte_physiolo3.52088518
4MP0001986_abnormal_taste_sensitivity3.36878407
5MP0002876_abnormal_thyroid_physiology3.29098209
6MP0002837_dystrophic_cardiac_calcinosis3.23492507
7MP0005645_abnormal_hypothalamus_physiol3.12542018
8MP0003183_abnormal_peptide_metabolism2.78520871
9MP0004043_abnormal_pH_regulation2.69600381
10MP0004147_increased_porphyrin_level2.65873580
11MP0002735_abnormal_chemical_nociception2.57571014
12MP0002909_abnormal_adrenal_gland2.49315615
13MP0002877_abnormal_melanocyte_morpholog2.46568194
14MP0010386_abnormal_urinary_bladder2.44911424
15MP0004859_abnormal_synaptic_plasticity2.43389762
16MP0003880_abnormal_central_pattern2.37337325
17MP0002102_abnormal_ear_morphology2.35702815
18MP0002693_abnormal_pancreas_physiology2.27505251
19MP0003283_abnormal_digestive_organ2.18825651
20MP0004215_abnormal_myocardial_fiber2.13874046
21MP0001501_abnormal_sleep_pattern2.07298788
22MP0003635_abnormal_synaptic_transmissio2.05719341
23MP0005464_abnormal_platelet_physiology1.96614547
24MP0002132_abnormal_respiratory_system1.92838371
25MP0004270_analgesia1.92519180
26MP0008004_abnormal_stomach_pH1.92132688
27MP0005310_abnormal_salivary_gland1.91753400
28MP0003303_peritoneal_inflammation1.90547446
29MP0002254_reproductive_system_inflammat1.85965024
30MP0004885_abnormal_endolymph1.81171292
31MP0002272_abnormal_nervous_system1.80050989
32MP0010155_abnormal_intestine_physiology1.77276615
33MP0003879_abnormal_hair_cell1.76077763
34MP0004264_abnormal_extraembryonic_tissu1.75146916
35MP0001664_abnormal_digestion1.72023951
36MP0009780_abnormal_chondrocyte_physiolo1.70232026
37MP0009745_abnormal_behavioral_response1.68112382
38MP0002734_abnormal_mechanical_nocicepti1.67764837
39MP0001188_hyperpigmentation1.67012156
40MP0004484_altered_response_of1.66184700
41MP0002139_abnormal_hepatobiliary_system1.64226579
42MP0005397_hematopoietic_system_phenotyp1.62635524
43MP0001545_abnormal_hematopoietic_system1.62635524
44MP0004036_abnormal_muscle_relaxation1.61109405
45MP0005085_abnormal_gallbladder_physiolo1.60800082
46MP0004084_abnormal_cardiac_muscle1.60100787
47MP0002009_preneoplasia1.59834639
48MP0002822_catalepsy1.59739718
49MP0002733_abnormal_thermal_nociception1.58046408
50MP0006276_abnormal_autonomic_nervous1.57412471
51MP0000462_abnormal_digestive_system1.56367850
52MP0000465_gastrointestinal_hemorrhage1.56366015
53MP0005360_urolithiasis1.56344837
54MP0001346_abnormal_lacrimal_gland1.55520153
55MP0001348_abnormal_lacrimal_gland1.55054820
56MP0000013_abnormal_adipose_tissue1.54982870
57MP0002064_seizures1.54530605
58MP0002572_abnormal_emotion/affect_behav1.50516342
59MP0009046_muscle_twitch1.50438033
60MP0005646_abnormal_pituitary_gland1.50421541
61MP0001944_abnormal_pancreas_morphology1.48495531
62MP0002736_abnormal_nociception_after1.48194465
63MP0005636_abnormal_mineral_homeostasis1.45762025
64MP0002063_abnormal_learning/memory/cond1.45573779
65MP0001440_abnormal_grooming_behavior1.45369472
66MP0000678_abnormal_parathyroid_gland1.45283598
67MP0001968_abnormal_touch/_nociception1.43789523
68MP0003866_abnormal_defecation1.41132025
69MP0001835_abnormal_antigen_presentation1.40727387
70MP0002928_abnormal_bile_duct1.37564187
71MP0004782_abnormal_surfactant_physiolog1.37228540
72MP0004085_abnormal_heartbeat1.35579628
73MP0008569_lethality_at_weaning1.35178628
74MP0008872_abnormal_physiological_respon1.34995794
75MP0001970_abnormal_pain_threshold1.34418050
76MP0003137_abnormal_impulse_conducting1.33898865
77MP0001485_abnormal_pinna_reflex1.33403489
78MP0001765_abnormal_ion_homeostasis1.27910174
79MP0006072_abnormal_retinal_apoptosis1.25964752
80MP0002166_altered_tumor_susceptibility1.25901223
81MP0005379_endocrine/exocrine_gland_phen1.24922881
82MP0002396_abnormal_hematopoietic_system1.18281634
83MP0001873_stomach_inflammation1.17721612
84MP0008775_abnormal_heart_ventricle1.16776084
85MP0002557_abnormal_social/conspecific_i1.15500709
86MP0002234_abnormal_pharynx_morphology1.15169626
87MP0001502_abnormal_circadian_rhythm1.13698465
88MP0001800_abnormal_humoral_immune1.12687467
89MP0005671_abnormal_response_to1.08580003
90MP0003329_amyloid_beta_deposits1.07796851
91MP0000003_abnormal_adipose_tissue1.07120688
92MP0003787_abnormal_imprinting1.06968063
93MP0009643_abnormal_urine_homeostasis1.06737891
94MP0002067_abnormal_sensory_capabilities1.05576938
95MP0005365_abnormal_bile_salt1.05237521
96MP0002972_abnormal_cardiac_muscle1.04838721
97MP0001486_abnormal_startle_reflex1.04790456
98MP0002078_abnormal_glucose_homeostasis1.04581280
99MP0004145_abnormal_muscle_electrophysio1.04322789
100MP0000490_abnormal_crypts_of1.04211229
101MP0003122_maternal_imprinting1.02060968
102MP0005083_abnormal_biliary_tract1.01907703
103MP0001790_abnormal_immune_system1.01494124
104MP0005387_immune_system_phenotype1.01494124
105MP0000685_abnormal_immune_system0.99868079
106MP0008260_abnormal_autophagy0.99725709
107MP0003195_calcinosis0.99715296
108MP0002398_abnormal_bone_marrow0.99621586
109MP0004742_abnormal_vestibular_system0.98131650
110MP0005670_abnormal_white_adipose0.97599800
111MP0008057_abnormal_DNA_replication0.95338515
112MP0006036_abnormal_mitochondrial_physio0.95060755
113MP0010329_abnormal_lipoprotein_level0.94999573
114MP0003724_increased_susceptibility_to0.94197725
115MP0000477_abnormal_intestine_morphology0.93310345
116MP0001661_extended_life_span0.92145599
117MP0000538_abnormal_urinary_bladder0.91859323
118MP0004510_myositis0.91842679
119MP0005166_decreased_susceptibility_to0.90919891
120MP0002136_abnormal_kidney_physiology0.88899751
121MP0000470_abnormal_stomach_morphology0.88756829
122MP0005332_abnormal_amino_acid0.88660753
123MP0005535_abnormal_body_temperature0.86958277
124MP0002229_neurodegeneration0.86330593
125MP0000230_abnormal_systemic_arterial0.85791599
126MP0002006_tumorigenesis0.85151181
127MP0000613_abnormal_salivary_gland0.84481790
128MP0001905_abnormal_dopamine_level0.83994353
129MP0000631_abnormal_neuroendocrine_gland0.83752685
130MP0005084_abnormal_gallbladder_morpholo0.83709551
131MP0003646_muscle_fatigue0.83430459
132MP0005385_cardiovascular_system_phenoty0.82925131
133MP0001544_abnormal_cardiovascular_syste0.82925131
134MP0003953_abnormal_hormone_level0.82057224
135MP0003868_abnormal_feces_composition0.80839796
136MP0003638_abnormal_response/metabolism_0.80199340
137MP0005381_digestive/alimentary_phenotyp0.80070626
138MP0004142_abnormal_muscle_tone0.79688375
139MP0005025_abnormal_response_to0.79418140
140MP0002723_abnormal_immune_serum0.77653886
141MP0000689_abnormal_spleen_morphology0.77413784
142MP0005000_abnormal_immune_tolerance0.77314842
143MP0002160_abnormal_reproductive_system0.76634334
144* MP0002420_abnormal_adaptive_immunity0.76194848
145MP0002277_abnormal_respiratory_mucosa0.75923714
146MP0005386_behavior/neurological_phenoty0.75658746
147MP0004924_abnormal_behavior0.75658746
148MP0006138_congestive_heart_failure0.75269891
149MP0005167_abnormal_blood-brain_barrier0.75267027
150MP0003300_gastrointestinal_ulcer0.74756699
151MP0009840_abnormal_foam_cell0.74724806
152MP0003045_fibrosis0.74472305
153* MP0001819_abnormal_immune_cell0.73839275
154MP0001666_abnormal_nutrient_absorption0.73547737
155MP0000716_abnormal_immune_system0.73372180
156MP0002066_abnormal_motor_capabilities/c0.73025174
157MP0002429_abnormal_blood_cell0.71321326
158MP0000566_synostosis0.71284333
159MP0001663_abnormal_digestive_system0.70167053
160MP0005423_abnormal_somatic_nervous0.69378540
161MP0002722_abnormal_immune_system0.69243614
162MP0009697_abnormal_copulation0.68376549
163MP0001756_abnormal_urination0.68206394
164MP0002452_abnormal_antigen_presenting0.66723704
165MP0008995_early_reproductive_senescence0.66701445
166MP0005409_darkened_coat_color0.65213824
167MP0008874_decreased_physiological_sensi0.65189016
168MP0005248_abnormal_Harderian_gland0.63898105

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)4.75093158
2Decreased circulating renin level (HP:0003351)4.44171899
3Hyperinsulinemic hypoglycemia (HP:0000825)4.26588154
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.15637988
5Focal motor seizures (HP:0011153)4.08476489
6Abnormality of calcium-phosphate metabolism (HP:0100530)3.89077369
7Symptomatic seizures (HP:0011145)3.72070737
8Chronic diarrhea (HP:0002028)3.64502355
9Ventricular fibrillation (HP:0001663)3.58805373
10Bundle branch block (HP:0011710)3.47641690
11Glomerulonephritis (HP:0000099)3.40626861
12Visual hallucinations (HP:0002367)3.25037661
13Pancreatic islet-cell hyperplasia (HP:0004510)3.20305302
14Hypoglycemic seizures (HP:0002173)3.18627913
15Acute necrotizing encephalopathy (HP:0006965)3.15967090
16Syncope (HP:0001279)3.13614668
17Prolonged QT interval (HP:0001657)3.12056489
18Abnormality of renin-angiotensin system (HP:0000847)3.04830819
19Right ventricular cardiomyopathy (HP:0011663)2.96838683
20Abnormal mitochondria in muscle tissue (HP:0008316)2.95275004
21Postural instability (HP:0002172)2.87617746
22Focal seizures (HP:0007359)2.87292390
23Agammaglobulinemia (HP:0004432)2.87196906
24Epileptic encephalopathy (HP:0200134)2.86413023
25Hyponatremia (HP:0002902)2.84529788
26Progressive macrocephaly (HP:0004481)2.82198354
27Abnormality of binocular vision (HP:0011514)2.77944066
28Diplopia (HP:0000651)2.77944066
29Double outlet right ventricle (HP:0001719)2.75529121
30Congenital malformation of the right heart (HP:0011723)2.75529121
31Abnormal pancreas size (HP:0012094)2.74993592
32Hyperactive renin-angiotensin system (HP:0000841)2.73826013
33Paralysis (HP:0003470)2.73418939
34Hypercortisolism (HP:0001578)2.73065661
35Prolonged bleeding time (HP:0003010)2.68610245
36Hypoglycemic coma (HP:0001325)2.67551265
37Febrile seizures (HP:0002373)2.60495593
38Large for gestational age (HP:0001520)2.60342313
39Atonic seizures (HP:0010819)2.60085845
40Abnormal EKG (HP:0003115)2.60068008
41Nephritis (HP:0000123)2.56446207
42Hypochromic microcytic anemia (HP:0004840)2.56107198
43Palpitations (HP:0001962)2.55722733
44Reticulocytosis (HP:0001923)2.55391221
45Microcytic anemia (HP:0001935)2.53673654
46Nausea (HP:0002018)2.50967373
47Poikilocytosis (HP:0004447)2.48030312
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.47992480
49Ventricular arrhythmia (HP:0004308)2.47779471
50Abnormality of the pancreatic islet cells (HP:0006476)2.46010502
51Abnormality of endocrine pancreas physiology (HP:0012093)2.46010502
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.45397041
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42462124
54Hyperphosphatemia (HP:0002905)2.41577582
55Polycythemia (HP:0001901)2.39515494
56Acute encephalopathy (HP:0006846)2.39423256
57Ventricular tachycardia (HP:0004756)2.37629269
58Mitochondrial inheritance (HP:0001427)2.35712803
59Abnormality of sodium homeostasis (HP:0010931)2.35630464
60Papillary thyroid carcinoma (HP:0002895)2.34903716
61Hyperglycinuria (HP:0003108)2.33995227
62Adrenal overactivity (HP:0002717)2.33662464
63Hyperglycemia (HP:0003074)2.33573929
64Sudden death (HP:0001699)2.32758833
65Hypokalemia (HP:0002900)2.31428757
66Hyperkalemia (HP:0002153)2.29268071
67Hyperparathyroidism (HP:0000843)2.26356132
68Central scotoma (HP:0000603)2.25836935
69Alacrima (HP:0000522)2.24638894
70Insulin-resistant diabetes mellitus (HP:0000831)2.24293555
71Petechiae (HP:0000967)2.24110925
72Atrial fibrillation (HP:0005110)2.23843980
73Abnormality of vitamin B metabolism (HP:0004340)2.23032974
74Inflammation of the large intestine (HP:0002037)2.21487874
75Confusion (HP:0001289)2.21128193
76Joint swelling (HP:0001386)2.19981085
77Colitis (HP:0002583)2.19835269
78Osteomyelitis (HP:0002754)2.19182302
79Abnormality of incisor morphology (HP:0011063)2.18127721
80Scotoma (HP:0000575)2.17747878
81Gastrointestinal infarctions (HP:0005244)2.17716064
82Pigmentary retinal degeneration (HP:0001146)2.16933035
83Vasculitis (HP:0002633)2.16578390
84Ankle clonus (HP:0011448)2.16325359
85Partial duplication of thumb phalanx (HP:0009944)2.15906554
86Ketoacidosis (HP:0001993)2.15257498
87Abnormal pupillary function (HP:0007686)2.14048679
88Abnormality of potassium homeostasis (HP:0011042)2.12185586
89Thyroid carcinoma (HP:0002890)2.11774256
90Toxemia of pregnancy (HP:0100603)2.11484521
91Primary atrial arrhythmia (HP:0001692)2.10855958
92Epileptiform EEG discharges (HP:0011182)2.08439150
93Chronic otitis media (HP:0000389)2.07481198
94Generalized tonic-clonic seizures (HP:0002069)2.07274004
95Cortical visual impairment (HP:0100704)2.07225707
96Agitation (HP:0000713)2.06722532
97Gastrointestinal inflammation (HP:0004386)2.06065059
98Anxiety (HP:0000739)2.05141317
99Panhypogammaglobulinemia (HP:0003139)2.04643088
100Abnormality of chloride homeostasis (HP:0011422)2.03290244
101Dialeptic seizures (HP:0011146)2.03210237
102Absence seizures (HP:0002121)2.02480994
103Autoimmune hemolytic anemia (HP:0001890)2.00774696
104Osteomalacia (HP:0002749)2.00654576
105EEG with generalized epileptiform discharges (HP:0011198)2.00247126
106Epistaxis (HP:0000421)1.99952122
107Metabolic alkalosis (HP:0200114)1.99316437
108Abnormality of the salivary glands (HP:0010286)1.98519818
109Type I transferrin isoform profile (HP:0003642)1.98143606
110Recurrent corneal erosions (HP:0000495)1.98060932
111Ileus (HP:0002595)1.97859187
112Partial duplication of the phalanx of hand (HP:0009999)1.97804981
113Hyperventilation (HP:0002883)1.97535387
114Gingival bleeding (HP:0000225)1.97354999
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.96818606
116Recurrent sinusitis (HP:0011108)1.96622441
117Supraventricular tachycardia (HP:0004755)1.96372166
118Hypothermia (HP:0002045)1.95948898
119Hyperaldosteronism (HP:0000859)1.94259267
120Increased circulating renin level (HP:0000848)1.93901296
121Encephalitis (HP:0002383)1.93826374
122Congenital sensorineural hearing impairment (HP:0008527)1.92926369
123Alkalosis (HP:0001948)1.92297976
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91994370
125Unilateral renal agenesis (HP:0000122)1.91750795
126Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.90955778
127Poor eye contact (HP:0000817)1.90068311
128Left ventricular hypertrophy (HP:0001712)1.89262053
129Increased CSF lactate (HP:0002490)1.89020814
130Supraventricular arrhythmia (HP:0005115)1.88665541
131Myokymia (HP:0002411)1.88537626
132Type I diabetes mellitus (HP:0100651)1.88128994
133Hypsarrhythmia (HP:0002521)1.87447877
134Abnormal social behavior (HP:0012433)1.87175969
135Impaired social interactions (HP:0000735)1.87175969
136Asplenia (HP:0001746)1.87170621
137Decreased lacrimation (HP:0000633)1.86715586
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.83383067
139Xerostomia (HP:0000217)1.81318462
140Vertigo (HP:0002321)1.80783119
141Gastrointestinal stroma tumor (HP:0100723)1.80637137
142Abnormality of the fovea (HP:0000493)1.80499224
143Paresthesia (HP:0003401)1.80182427
144Decreased central vision (HP:0007663)1.79430595
145Meningitis (HP:0001287)1.79046205
14611 pairs of ribs (HP:0000878)1.78544588
147Abnormal protein glycosylation (HP:0012346)1.77597145
148Abnormal glycosylation (HP:0012345)1.77597145
149Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77597145
150Abnormal protein N-linked glycosylation (HP:0012347)1.77597145
151Papilledema (HP:0001085)1.77513690
152Hypoplasia of dental enamel (HP:0006297)1.77403901
153Abnormality of the fingertips (HP:0001211)1.76873304
154Hypochromic anemia (HP:0001931)1.76853917
155Abnormality of the periventricular white matter (HP:0002518)1.76622993
156Exocrine pancreatic insufficiency (HP:0001738)1.76252740
157Recurrent viral infections (HP:0004429)1.75972535
158Failure to thrive in infancy (HP:0001531)1.75233874
159Cholelithiasis (HP:0001081)1.74663430
160Widely patent fontanelles and sutures (HP:0004492)1.74608685
161Abnormality of serine family amino acid metabolism (HP:0010894)1.73659252
162Abnormality of glycine metabolism (HP:0010895)1.73659252
163Congenital primary aphakia (HP:0007707)1.73126245
164Abnormal biliary tract morphology (HP:0012440)1.72309535
165Medial flaring of the eyebrow (HP:0010747)1.70556387
166Flat acetabular roof (HP:0003180)1.70312691
167Abnormal ciliary motility (HP:0012262)1.70092472
168Metabolic acidosis (HP:0001942)1.69725450
169Stomach cancer (HP:0012126)1.69546318
170Gait imbalance (HP:0002141)1.69217483
171Renal tubular acidosis (HP:0001947)1.69113965
172Aplasia/hypoplasia of the uterus (HP:0008684)1.67808106
173Nonprogressive disorder (HP:0003680)1.66819874
174Aplasia/Hypoplasia of the fovea (HP:0008060)1.66572556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.84428153
2INSRR4.02711713
3TNIK3.58437971
4NTRK33.56669742
5MATK2.77742202
6NME12.64227359
7CDK192.48112413
8WNK42.20707902
9MAPK152.18450198
10FRK2.09895732
11LMTK22.06343994
12CASK1.95465830
13TAOK31.94190216
14MAPKAPK51.92185133
15IRAK41.82068702
16PASK1.76680778
17BMPR21.76606404
18MST41.70282734
19AKT31.61135569
20HIPK21.60064925
21MAP3K21.57517432
22PRKD31.48737967
23* SYK1.48000729
24MAP3K121.47214874
25NUAK11.44536240
26CDC42BPA1.41295001
27MAP4K11.40584982
28NTRK11.39240995
29MUSK1.33577705
30GRK51.33203386
31RIPK11.30566034
32GRK61.26995436
33EPHA41.25985872
34CAMK2D1.25584483
35PDK21.24174969
36PDK11.23090340
37IRAK11.22641882
38MYLK1.21274593
39ERBB31.20461401
40PRKCE1.20245241
41STK391.17220726
42JAK21.16586307
43MAP2K31.15452932
44WNK11.15076275
45MAP2K71.12591888
46IRAK31.12543210
47BCR1.12428713
48PRPF4B1.12411512
49CAMKK21.12395559
50MAP3K11.11861765
51PAK31.09908083
52CAMK2A1.09581126
53FGFR31.09537579
54CDK31.09433109
55TEC1.09008319
56DMPK1.08471290
57UHMK11.04814753
58STK41.04572510
59PRKG21.04343271
60EIF2AK11.04230541
61PIM11.02804821
62CAMK2B1.01560116
63TNK21.01138997
64RAF11.00530351
65MAP3K130.99752619
66KSR20.96373505
67SGK20.96094152
68RET0.95402124
69BTK0.94632704
70MAP3K110.94117306
71MAP3K140.93011233
72MAP2K20.90050856
73FLT30.89038950
74GRK10.88727244
75PINK10.87856018
76DYRK1B0.87681771
77BRAF0.86948491
78BRSK20.86579962
79CAMK10.85483741
80MAP3K50.85156136
81KIT0.82720446
82PTK2B0.82532483
83PRKD20.81651782
84LYN0.81061764
85CCNB10.80322329
86ARAF0.79952805
87PDPK10.79750545
88DYRK1A0.79609873
89VRK10.79420220
90RIPK40.79031520
91PIK3CG0.78423985
92EPHA30.77358376
93MAP3K60.77313045
94MAP3K40.77006527
95GRK70.76818709
96MKNK10.76576694
97* PRKCQ0.74347562
98STK110.73522586
99MAPK120.72370790
100BLK0.72109413
101YES10.71068902
102MAPK130.69289012
103BMX0.69286928
104KSR10.68619472
105MAP3K70.67194702
106IKBKE0.64370969
107ITK0.64008262
108CDK50.62474917
109SGK4940.62417625
110SGK2230.62417625
111PLK40.61993888
112PRKCI0.61281335
113MAP4K20.60419875
114STK240.59870580
115ERBB20.59328139
116PTK20.58960953
117MST1R0.58900859
118NEK60.58563142
119* PRKACA0.57746687
120CAMKK10.57715310
121PRKCH0.57588760
122MET0.57510991
123PRKAA20.56354530
124FES0.55712864
125PIK3CA0.55522551
126STK30.55336795
127IRAK20.55015376
128EIF2AK30.53604776
129SGK10.53224708
130CAMK2G0.52752583
131DYRK30.51861909
132FER0.51393564
133MARK30.50842962
134MAP2K10.49565430
135BMPR1B0.49348284
136PLK20.48843068
137PRKG10.48667719
138SCYL20.48397274
139TRPM70.45736443
140PRKACG0.45399337
141SGK30.44366230
142EPHB10.44358717
143OXSR10.42822127
144DAPK10.42732323
145PRKCZ0.42452208
146DAPK20.42358089
147JAK30.42065430
148MAP2K40.41773060
149MAPK110.41704267
150PRKCG0.40757500
151FGR0.40517188
152MAPK70.39848014
153CSF1R0.39792733
154FYN0.39341427
155HCK0.39157946

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.36202695
2Nitrogen metabolism_Homo sapiens_hsa009103.70478783
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.49133949
4Taste transduction_Homo sapiens_hsa047422.64694073
5Protein export_Homo sapiens_hsa030602.63382935
6Insulin secretion_Homo sapiens_hsa049112.49451559
7Nicotine addiction_Homo sapiens_hsa050332.24395888
8Asthma_Homo sapiens_hsa053102.21415878
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.21293900
10Oxidative phosphorylation_Homo sapiens_hsa001902.18042181
11Sulfur metabolism_Homo sapiens_hsa009202.03871667
12Allograft rejection_Homo sapiens_hsa053302.03304972
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.96186261
14Amphetamine addiction_Homo sapiens_hsa050311.94329429
15Long-term potentiation_Homo sapiens_hsa047201.91785879
16Serotonergic synapse_Homo sapiens_hsa047261.89244777
17Alzheimers disease_Homo sapiens_hsa050101.78871801
18Circadian entrainment_Homo sapiens_hsa047131.76839177
19Pancreatic secretion_Homo sapiens_hsa049721.70511628
20GABAergic synapse_Homo sapiens_hsa047271.68831825
21Cardiac muscle contraction_Homo sapiens_hsa042601.67449050
22Vibrio cholerae infection_Homo sapiens_hsa051101.67383541
23Glutamatergic synapse_Homo sapiens_hsa047241.64574409
24Autoimmune thyroid disease_Homo sapiens_hsa053201.64447047
25Morphine addiction_Homo sapiens_hsa050321.63972345
26Parkinsons disease_Homo sapiens_hsa050121.57030841
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.56196640
28Synaptic vesicle cycle_Homo sapiens_hsa047211.53419067
29Salivary secretion_Homo sapiens_hsa049701.52786575
30Bile secretion_Homo sapiens_hsa049761.50023343
31B cell receptor signaling pathway_Homo sapiens_hsa046621.49164842
32Type II diabetes mellitus_Homo sapiens_hsa049301.48244958
33Collecting duct acid secretion_Homo sapiens_hsa049661.46414661
34Graft-versus-host disease_Homo sapiens_hsa053321.45448336
35Caffeine metabolism_Homo sapiens_hsa002321.42863289
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40251548
37Long-term depression_Homo sapiens_hsa047301.38687387
38Linoleic acid metabolism_Homo sapiens_hsa005911.37448324
39Arginine biosynthesis_Homo sapiens_hsa002201.36072616
40Type I diabetes mellitus_Homo sapiens_hsa049401.35058024
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34216569
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33832784
43Gastric acid secretion_Homo sapiens_hsa049711.30687474
44Dopaminergic synapse_Homo sapiens_hsa047281.30419161
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28254529
46Vitamin digestion and absorption_Homo sapiens_hsa049771.26739178
47Calcium signaling pathway_Homo sapiens_hsa040201.26428346
48Cholinergic synapse_Homo sapiens_hsa047251.20708354
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19926165
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19113112
51Leishmaniasis_Homo sapiens_hsa051401.16880762
52Platelet activation_Homo sapiens_hsa046111.16803181
53Cocaine addiction_Homo sapiens_hsa050301.16456850
54Olfactory transduction_Homo sapiens_hsa047401.14269059
55* Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13732777
56Huntingtons disease_Homo sapiens_hsa050161.10396973
57Vascular smooth muscle contraction_Homo sapiens_hsa042701.10284427
58Ether lipid metabolism_Homo sapiens_hsa005651.10185696
59Renin-angiotensin system_Homo sapiens_hsa046141.07192083
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07137100
61Primary immunodeficiency_Homo sapiens_hsa053401.06146465
62Mineral absorption_Homo sapiens_hsa049781.06112683
63Propanoate metabolism_Homo sapiens_hsa006401.03688740
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99739970
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98727029
66Fatty acid degradation_Homo sapiens_hsa000710.97228785
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97095981
68Arachidonic acid metabolism_Homo sapiens_hsa005900.95816639
69Renin secretion_Homo sapiens_hsa049240.94950164
70Thyroid hormone synthesis_Homo sapiens_hsa049180.94190084
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94062169
72cAMP signaling pathway_Homo sapiens_hsa040240.90513868
73Circadian rhythm_Homo sapiens_hsa047100.89595716
74Staphylococcus aureus infection_Homo sapiens_hsa051500.89201680
75Dorso-ventral axis formation_Homo sapiens_hsa043200.88304885
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87890199
77Sphingolipid metabolism_Homo sapiens_hsa006000.87785401
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87017526
79Dilated cardiomyopathy_Homo sapiens_hsa054140.85277612
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84280794
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84081216
82Oxytocin signaling pathway_Homo sapiens_hsa049210.83145735
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82013396
84GnRH signaling pathway_Homo sapiens_hsa049120.81827320
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81019459
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79730670
87PPAR signaling pathway_Homo sapiens_hsa033200.78680734
88Hematopoietic cell lineage_Homo sapiens_hsa046400.77628423
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76041710
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74533881
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73690315
92Glycerolipid metabolism_Homo sapiens_hsa005610.73092204
93Estrogen signaling pathway_Homo sapiens_hsa049150.72983014
94Arginine and proline metabolism_Homo sapiens_hsa003300.72503826
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71777640
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71089419
97Starch and sucrose metabolism_Homo sapiens_hsa005000.70266217
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68912023
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68187512
100Fat digestion and absorption_Homo sapiens_hsa049750.67855024
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64897962
102ABC transporters_Homo sapiens_hsa020100.64703135
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64671113
104* Inositol phosphate metabolism_Homo sapiens_hsa005620.63731855
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63473762
106Gap junction_Homo sapiens_hsa045400.62576480
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62429075
108N-Glycan biosynthesis_Homo sapiens_hsa005100.61698981
109Ovarian steroidogenesis_Homo sapiens_hsa049130.61509929
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.59427198
111* Choline metabolism in cancer_Homo sapiens_hsa052310.57256029
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57133758
113Melanogenesis_Homo sapiens_hsa049160.53883023
114Chemical carcinogenesis_Homo sapiens_hsa052040.52997115
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49382275
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48667416
117Ras signaling pathway_Homo sapiens_hsa040140.48465017
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.48087720
119Chemokine signaling pathway_Homo sapiens_hsa040620.47706319
120* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47121590
121Retinol metabolism_Homo sapiens_hsa008300.46000962
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45986702
123Influenza A_Homo sapiens_hsa051640.45031155
124Tuberculosis_Homo sapiens_hsa051520.44635040
125MAPK signaling pathway_Homo sapiens_hsa040100.44129925
126Glucagon signaling pathway_Homo sapiens_hsa049220.44103885
127Antigen processing and presentation_Homo sapiens_hsa046120.42159043
128Tryptophan metabolism_Homo sapiens_hsa003800.42123618
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42036651
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.42010873
131Non-small cell lung cancer_Homo sapiens_hsa052230.40007621
132Protein digestion and absorption_Homo sapiens_hsa049740.39592528
133* Phospholipase D signaling pathway_Homo sapiens_hsa040720.39387917
134Alcoholism_Homo sapiens_hsa050340.39248578
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.39115385
136ErbB signaling pathway_Homo sapiens_hsa040120.37034779
137Galactose metabolism_Homo sapiens_hsa000520.36949524
138Intestinal immune network for IgA production_Homo sapiens_hsa046720.36411576
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36218686
140VEGF signaling pathway_Homo sapiens_hsa043700.35507823
141Histidine metabolism_Homo sapiens_hsa003400.34871122
142Regulation of autophagy_Homo sapiens_hsa041400.34245051
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34240988
144Prolactin signaling pathway_Homo sapiens_hsa049170.33935148

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