PIPOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.71686686
2L-phenylalanine catabolic process (GO:0006559)7.71686686
3L-phenylalanine metabolic process (GO:0006558)7.42747819
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.42747819
5aromatic amino acid family catabolic process (GO:0009074)7.01766823
6epoxygenase P450 pathway (GO:0019373)6.68892486
7omega-hydroxylase P450 pathway (GO:0097267)6.52024090
8indole-containing compound catabolic process (GO:0042436)6.40026212
9indolalkylamine catabolic process (GO:0046218)6.40026212
10tryptophan catabolic process (GO:0006569)6.40026212
11glyoxylate metabolic process (GO:0046487)6.28396907
12kynurenine metabolic process (GO:0070189)6.13359877
13blood coagulation, intrinsic pathway (GO:0007597)6.07239745
14tryptophan metabolic process (GO:0006568)6.02846172
15cysteine metabolic process (GO:0006534)5.90831531
16bile acid biosynthetic process (GO:0006699)5.89205931
17triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.84949317
18serine family amino acid catabolic process (GO:0009071)5.51512712
19urea cycle (GO:0000050)5.49203750
20urea metabolic process (GO:0019627)5.49203750
21sulfur amino acid catabolic process (GO:0000098)5.45325446
22alpha-linolenic acid metabolic process (GO:0036109)5.39043259
23homocysteine metabolic process (GO:0050667)5.23157216
24negative regulation of fibrinolysis (GO:0051918)5.19743578
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.14519255
26aromatic amino acid family metabolic process (GO:0009072)5.11911609
27high-density lipoprotein particle remodeling (GO:0034375)5.11201145
28oxidative demethylation (GO:0070989)5.07484137
29nitrogen cycle metabolic process (GO:0071941)5.06966039
30peptidyl-glutamic acid carboxylation (GO:0017187)4.99412804
31protein carboxylation (GO:0018214)4.99412804
32bile acid metabolic process (GO:0008206)4.98695660
33regulation of fibrinolysis (GO:0051917)4.98419445
34complement activation, alternative pathway (GO:0006957)4.97973232
35regulation of plasminogen activation (GO:0010755)4.95454679
36regulation of protein activation cascade (GO:2000257)4.94616514
37amino-acid betaine metabolic process (GO:0006577)4.87550719
38* lysine metabolic process (GO:0006553)4.87463652
39* lysine catabolic process (GO:0006554)4.87463652
40* alpha-amino acid catabolic process (GO:1901606)4.81419905
41phenylpropanoid metabolic process (GO:0009698)4.78348066
42tyrosine metabolic process (GO:0006570)4.76098404
43serine family amino acid metabolic process (GO:0009069)4.66804376
44intestinal cholesterol absorption (GO:0030299)4.65837168
45glycine metabolic process (GO:0006544)4.64873356
46regulation of complement activation (GO:0030449)4.62184549
47cellular ketone body metabolic process (GO:0046950)4.58709551
48drug catabolic process (GO:0042737)4.56249325
49regulation of cholesterol esterification (GO:0010872)4.53439232
50indolalkylamine metabolic process (GO:0006586)4.52646062
51urate metabolic process (GO:0046415)4.52058282
52* cellular amino acid catabolic process (GO:0009063)4.48433936
53regulation of triglyceride catabolic process (GO:0010896)4.48076356
54glutamate metabolic process (GO:0006536)4.46864832
55negative regulation of cholesterol transport (GO:0032375)4.46586276
56negative regulation of sterol transport (GO:0032372)4.46586276
57serine family amino acid biosynthetic process (GO:0009070)4.46085998
58reverse cholesterol transport (GO:0043691)4.44625625
59cellular modified amino acid catabolic process (GO:0042219)4.42010811
60amine catabolic process (GO:0009310)4.40885878
61cellular biogenic amine catabolic process (GO:0042402)4.40885878
62ethanol metabolic process (GO:0006067)4.39875127
63protein-lipid complex remodeling (GO:0034368)4.39082411
64macromolecular complex remodeling (GO:0034367)4.39082411
65plasma lipoprotein particle remodeling (GO:0034369)4.39082411
66drug transmembrane transport (GO:0006855)4.38716500
67negative regulation of hemostasis (GO:1900047)4.38053939
68negative regulation of blood coagulation (GO:0030195)4.38053939
69triglyceride homeostasis (GO:0070328)4.36439539
70acylglycerol homeostasis (GO:0055090)4.36439539
71protein activation cascade (GO:0072376)4.35275237
72coenzyme catabolic process (GO:0009109)4.33893489
73very-low-density lipoprotein particle assembly (GO:0034379)4.32317963
74cellular glucuronidation (GO:0052695)4.25984698
75benzene-containing compound metabolic process (GO:0042537)4.25401871
76S-adenosylmethionine metabolic process (GO:0046500)4.24123432
77negative regulation of protein activation cascade (GO:2000258)4.23296649
78imidazole-containing compound metabolic process (GO:0052803)4.22610825
79bile acid and bile salt transport (GO:0015721)4.20011795
80ethanol oxidation (GO:0006069)4.17883854
81aldehyde catabolic process (GO:0046185)4.15414953
82phospholipid efflux (GO:0033700)4.15182360
83short-chain fatty acid metabolic process (GO:0046459)4.13911726
84dicarboxylic acid biosynthetic process (GO:0043650)4.11998361
85exogenous drug catabolic process (GO:0042738)4.07464942
86plasma lipoprotein particle clearance (GO:0034381)4.02784741
87negative regulation of coagulation (GO:0050819)3.99227577
88arginine metabolic process (GO:0006525)3.99216175
89ketone body metabolic process (GO:1902224)3.96497739
90negative regulation of wound healing (GO:0061045)3.94723144
91acute-phase response (GO:0006953)3.94096829
92alkaloid metabolic process (GO:0009820)3.93169636
93negative regulation of lipase activity (GO:0060192)3.92191142
94* carboxylic acid catabolic process (GO:0046395)3.92084479
95* organic acid catabolic process (GO:0016054)3.92084479
96heme transport (GO:0015886)3.90767844
97positive regulation of blood coagulation (GO:0030194)3.90056349
98positive regulation of hemostasis (GO:1900048)3.90056349
99uronic acid metabolic process (GO:0006063)3.84807062
100glucuronate metabolic process (GO:0019585)3.84807062
101regulation of humoral immune response (GO:0002920)3.83532988
102cholesterol efflux (GO:0033344)3.81401106
103complement activation, classical pathway (GO:0006958)3.80981531
104regulation of bile acid biosynthetic process (GO:0070857)3.80684734
105positive regulation of lipoprotein lipase activity (GO:0051006)3.77152610
106positive regulation of triglyceride lipase activity (GO:0061365)3.77152610
1072-oxoglutarate metabolic process (GO:0006103)3.74467998
108complement activation (GO:0006956)3.73375393
109low-density lipoprotein particle remodeling (GO:0034374)3.73125092
110regulation of cholesterol homeostasis (GO:2000188)3.72921796
111fibrinolysis (GO:0042730)3.71215663
112plasma lipoprotein particle assembly (GO:0034377)3.67897450
113plasma lipoprotein particle organization (GO:0071827)3.66594852
114drug transport (GO:0015893)3.65731428
115* acetyl-CoA metabolic process (GO:0006084)3.64226029
116cofactor catabolic process (GO:0051187)3.62737667
117drug metabolic process (GO:0017144)3.61947167
118fatty acid beta-oxidation (GO:0006635)3.61682213
119cholesterol homeostasis (GO:0042632)3.61187696
120carnitine metabolic process (GO:0009437)3.61112359
121fatty acid oxidation (GO:0019395)3.60742788
122monocarboxylic acid catabolic process (GO:0072329)3.60045483
123positive regulation of coagulation (GO:0050820)3.59207516
124* aspartate family amino acid catabolic process (GO:0009068)3.58623010
125sterol homeostasis (GO:0055092)3.57550063
126nicotinamide nucleotide biosynthetic process (GO:0019359)3.57159520
127pyridine nucleotide biosynthetic process (GO:0019363)3.57159520
128phospholipid homeostasis (GO:0055091)3.56516931
129NAD biosynthetic process (GO:0009435)3.56284678
130negative regulation of complement activation (GO:0045916)3.54785164
131flavonoid metabolic process (GO:0009812)3.53794741
132sodium-independent organic anion transport (GO:0043252)3.45841182
133fat-soluble vitamin biosynthetic process (GO:0042362)3.40744494
134regulation of apoptotic cell clearance (GO:2000425)3.40695052
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40638835
136cytolysis (GO:0019835)3.39666264
137L-serine metabolic process (GO:0006563)3.37688027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.46237496
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.28178920
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.92013666
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.48430928
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.16436969
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04787280
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89326640
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.10768809
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97362726
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77550501
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.24410091
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.16142498
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13811142
14GBX2_23144817_ChIP-Seq_PC3_Human2.12554382
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0173893
16IGF1R_20145208_ChIP-Seq_DFB_Human1.91177553
17ZNF274_21170338_ChIP-Seq_K562_Hela1.77949514
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70348951
19CLOCK_20551151_ChIP-Seq_293T_Human1.65254155
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64573520
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.59487671
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54383346
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53464691
24* HNF4A_19822575_ChIP-Seq_HepG2_Human1.49542317
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.42159096
26TAF15_26573619_Chip-Seq_HEK293_Human1.37034784
27BCAT_22108803_ChIP-Seq_LS180_Human1.35985495
28HTT_18923047_ChIP-ChIP_STHdh_Human1.34690950
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.33444030
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32714106
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32204342
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32049557
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.27552652
34VDR_22108803_ChIP-Seq_LS180_Human1.25680689
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24326377
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24103006
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.22693249
38* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21056685
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.20688718
40ER_23166858_ChIP-Seq_MCF-7_Human1.18377890
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16810559
42* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16568376
43KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14392466
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14090517
45GATA1_22025678_ChIP-Seq_K562_Human1.13762177
46ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13598757
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12624276
48P300_19829295_ChIP-Seq_ESCs_Human1.12365911
49NANOG_19829295_ChIP-Seq_ESCs_Human1.12039777
50SOX2_19829295_ChIP-Seq_ESCs_Human1.12039777
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11079938
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07650777
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04651952
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03562736
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03097436
56* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02672151
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02453509
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02314150
59TCF4_22108803_ChIP-Seq_LS180_Human1.02069835
60STAT3_23295773_ChIP-Seq_U87_Human1.00909136
61* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00655213
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98676453
63CBP_20019798_ChIP-Seq_JUKART_Human0.98676453
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.98452260
65* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96675607
66* CRX_20693478_ChIP-Seq_RETINA_Mouse0.95645418
67* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93305299
68RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92598574
69GATA4_25053715_ChIP-Seq_YYC3_Human0.91173334
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90839475
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90053579
72TCF4_23295773_ChIP-Seq_U87_Human0.89800676
73FOXA1_25329375_ChIP-Seq_VCAP_Human0.89577133
74FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89577133
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89144451
76OCT4_18555785_Chip-Seq_ESCs_Mouse0.87594431
77MYC_19829295_ChIP-Seq_ESCs_Human0.87430974
78AR_25329375_ChIP-Seq_VCAP_Human0.87420287
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86694229
80STAT3_18555785_Chip-Seq_ESCs_Mouse0.86192013
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85285667
82SMAD1_18555785_Chip-Seq_ESCs_Mouse0.85169444
83* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84944117
84RUNX1_27457419_Chip-Seq_LIVER_Mouse0.84030028
85NANOG_18555785_Chip-Seq_ESCs_Mouse0.83249408
86P300_18555785_Chip-Seq_ESCs_Mouse0.83243340
87OCT4_21477851_ChIP-Seq_ESCs_Mouse0.83125929
88RUNX2_22187159_ChIP-Seq_PCA_Human0.83002739
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82938258
90P53_22387025_ChIP-Seq_ESCs_Mouse0.82913589
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.82547272
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82455760
93SMAD4_21741376_ChIP-Seq_EPCs_Human0.82248711
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82227559
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81696274
96NCOR_22424771_ChIP-Seq_293T_Human0.81275989
97ZNF263_19887448_ChIP-Seq_K562_Human0.81134541
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.81078260
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81069586
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77527524
101* SMAD4_21799915_ChIP-Seq_A2780_Human0.77367240
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77310036
103REST_21632747_ChIP-Seq_MESCs_Mouse0.77308540
104AR_21572438_ChIP-Seq_LNCaP_Human0.77191706
105RARA_24833708_ChIP-Seq_LIVER_Mouse0.77077229
106SUZ12_18555785_Chip-Seq_ESCs_Mouse0.77063476
107FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76706338
108TCF4_18268006_ChIP-ChIP_LS174T_Human0.76415983
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76026849
110* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75903916
111SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74160718
112ESR1_21235772_ChIP-Seq_MCF-7_Human0.73550114
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.73441481
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72349596
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68147315
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67137226
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.65148295
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63576819
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63318079
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63018479
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63016886
122* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61708404
123CEBPB_22108803_ChIP-Seq_LS180_Human0.59957696
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.59453915
125IRF8_22096565_ChIP-ChIP_GC-B_Human0.59201015
126LXR_22292898_ChIP-Seq_THP-1_Human0.58568898
127* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.55741683
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.55060844
129EGR1_19032775_ChIP-ChIP_M12_Human0.54473981
130AR_20517297_ChIP-Seq_VCAP_Human0.54068738
131MYC_19915707_ChIP-ChIP_AK7_Human0.53600397
132GATA6_25053715_ChIP-Seq_YYC3_Human0.52673914
133ESET_19884257_ChIP-Seq_ESCs_Mouse0.52582696
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51699468
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.51239669
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.51239669
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50252729
138AR_21909140_ChIP-Seq_LNCAP_Human0.48727530
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.48268697
140FOXA1_25552417_ChIP-Seq_VCAP_Human0.47746309
141CBP_21632823_ChIP-Seq_H3396_Human0.46865566
142* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.45301000
143STAT1_17558387_ChIP-Seq_HELA_Human0.44072460
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44050395
145STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.44001688
146TAF2_19829295_ChIP-Seq_ESCs_Human0.43690866
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.42970222
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42618260
149P53_21459846_ChIP-Seq_SAOS-2_Human0.42186460
150* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.42069445
151GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.41789186
152NANOG_16518401_ChIP-PET_MESCs_Mouse0.40966938
153* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.39782558
154PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.39346799
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.39133175
156* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.39043857
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.38451510
158SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38274302
159IRF1_19129219_ChIP-ChIP_H3396_Human0.38249953
160CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37496230
161* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.37253206
162PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37085218
163SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.36009025
164NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.36000799
165P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.35556738
166CDX2_22108803_ChIP-Seq_LS180_Human0.35206907
167SPI1_26923725_Chip-Seq_HPCs_Mouse0.35046013
168FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.34488079
169TET1_21451524_ChIP-Seq_MESCs_Mouse0.34349618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.23773502
2MP0005360_urolithiasis8.02684131
3MP0005085_abnormal_gallbladder_physiolo6.25255085
4MP0005365_abnormal_bile_salt5.96840564
5MP0008875_abnormal_xenobiotic_pharmacok5.10155254
6MP0003806_abnormal_nucleotide_metabolis4.36080883
7MP0003252_abnormal_bile_duct3.91502899
8MP0010329_abnormal_lipoprotein_level3.34723413
9MP0005332_abnormal_amino_acid3.24174056
10MP0003195_calcinosis3.09984190
11MP0009840_abnormal_foam_cell2.93657835
12MP0005083_abnormal_biliary_tract2.79774728
13MP0004019_abnormal_vitamin_homeostasis2.66579275
14MP0001666_abnormal_nutrient_absorption2.51380716
15MP0002138_abnormal_hepatobiliary_system2.29501450
16MP0003122_maternal_imprinting2.24134345
17MP0003191_abnormal_cellular_cholesterol2.12492851
18MP0000609_abnormal_liver_physiology2.05394968
19MP0002118_abnormal_lipid_homeostasis2.01287820
20MP0005319_abnormal_enzyme/_coenzyme1.86554814
21MP0001764_abnormal_homeostasis1.72071103
22MP0003868_abnormal_feces_composition1.71578636
23MP0009643_abnormal_urine_homeostasis1.65116658
24MP0005584_abnormal_enzyme/coenzyme_acti1.61718152
25MP0003186_abnormal_redox_activity1.48142839
26MP0005451_abnormal_body_composition1.40438093
27MP0009697_abnormal_copulation1.34569677
28MP0005636_abnormal_mineral_homeostasis1.23117208
29MP0003011_delayed_dark_adaptation1.20134584
30MP0000598_abnormal_liver_morphology1.15850427
31MP0003705_abnormal_hypodermis_morpholog1.13031379
32MP0005647_abnormal_sex_gland1.05485447
33MP0005551_abnormal_eye_electrophysiolog1.05203515
34MP0003656_abnormal_erythrocyte_physiolo1.03628777
35MP0001984_abnormal_olfaction1.00145455
36MP0009764_decreased_sensitivity_to0.98852358
37MP0006292_abnormal_olfactory_placode0.97746351
38MP0004043_abnormal_pH_regulation0.96471338
39MP0001756_abnormal_urination0.94397902
40MP0006036_abnormal_mitochondrial_physio0.94345541
41MP0002909_abnormal_adrenal_gland0.92701496
42MP0009763_increased_sensitivity_to0.92239136
43MP0000604_amyloidosis0.91983114
44MP0002254_reproductive_system_inflammat0.90506516
45MP0003121_genomic_imprinting0.88999463
46MP0005670_abnormal_white_adipose0.88732188
47MP0005084_abnormal_gallbladder_morpholo0.88217816
48MP0009642_abnormal_blood_homeostasis0.87496593
49MP0002132_abnormal_respiratory_system0.83709551
50MP0001915_intracranial_hemorrhage0.83371675
51MP0008469_abnormal_protein_level0.83356401
52MP0000566_synostosis0.83066783
53MP0005408_hypopigmentation0.82521533
54MP0005377_hearing/vestibular/ear_phenot0.82220198
55MP0003878_abnormal_ear_physiology0.82220198
56MP0002876_abnormal_thyroid_physiology0.81328818
57MP0003123_paternal_imprinting0.80902143
58MP0002136_abnormal_kidney_physiology0.80275590
59MP0005376_homeostasis/metabolism_phenot0.79383765
60MP0003136_yellow_coat_color0.77741137
61MP0005220_abnormal_exocrine_pancreas0.76863606
62MP0003890_abnormal_embryonic-extraembry0.75277093
63MP0009765_abnormal_xenobiotic_induced0.74736388
64MP0002078_abnormal_glucose_homeostasis0.74595545
65MP0001661_extended_life_span0.71866391
66MP0003879_abnormal_hair_cell0.71806366
67MP0010368_abnormal_lymphatic_system0.70259425
68MP0005646_abnormal_pituitary_gland0.70083591
69MP0005266_abnormal_metabolism0.69451754
70MP0005535_abnormal_body_temperature0.69246453
71MP0002938_white_spotting0.69242268
72MP0005187_abnormal_penis_morphology0.69170041
73MP0002971_abnormal_brown_adipose0.64952753
74MP0002090_abnormal_vision0.63300082
75MP0009053_abnormal_anal_canal0.63280146
76MP0003283_abnormal_digestive_organ0.62208756
77MP0006035_abnormal_mitochondrial_morpho0.62179955
78MP0002282_abnormal_trachea_morphology0.61718584
79MP0003567_abnormal_fetal_cardiomyocyte0.61527835
80MP0005334_abnormal_fat_pad0.60307326
81MP0004133_heterotaxia0.59227717
82MP0001324_abnormal_eye_pigmentation0.58687515
83MP0004142_abnormal_muscle_tone0.58648136
84MP0001765_abnormal_ion_homeostasis0.58471917
85MP0002928_abnormal_bile_duct0.56882124
86MP0003329_amyloid_beta_deposits0.56332541
87MP0003690_abnormal_glial_cell0.56253359
88MP0002089_abnormal_postnatal_growth/wei0.55936535
89MP0005395_other_phenotype0.55656591
90MP0001986_abnormal_taste_sensitivity0.55242993
91MP0004130_abnormal_muscle_cell0.54999109
92MP0003638_abnormal_response/metabolism_0.53949459
93MP0008877_abnormal_DNA_methylation0.50440776
94MP0003718_maternal_effect0.50258157
95MP0002638_abnormal_pupillary_reflex0.47265953
96MP0003787_abnormal_imprinting0.46825955
97MP0001944_abnormal_pancreas_morphology0.46675007
98MP0003632_abnormal_nervous_system0.46467733
99MP0003633_abnormal_nervous_system0.46331989
100MP0000639_abnormal_adrenal_gland0.46224146
101MP0005666_abnormal_adipose_tissue0.45919052
102MP0005410_abnormal_fertilization0.45913099
103MP0001529_abnormal_vocalization0.45264842
104MP0005448_abnormal_energy_balance0.44438237
105MP0005379_endocrine/exocrine_gland_phen0.43955670
106MP0002168_other_aberrant_phenotype0.42388598
107MP0009672_abnormal_birth_weight0.42102035
108MP0003953_abnormal_hormone_level0.41910455
109MP0002557_abnormal_social/conspecific_i0.41008496
110MP0002796_impaired_skin_barrier0.41002879
111MP0008873_increased_physiological_sensi0.40627544
112MP0009046_muscle_twitch0.40214955
113MP0009745_abnormal_behavioral_response0.40015588
114MP0008872_abnormal_physiological_respon0.39894181
115MP0005058_abnormal_lysosome_morphology0.39776926
116MP0006072_abnormal_retinal_apoptosis0.39290410
117MP0000230_abnormal_systemic_arterial0.38333566
118MP0008874_decreased_physiological_sensi0.38076437
119MP0004782_abnormal_surfactant_physiolog0.34687861
120MP0004264_abnormal_extraembryonic_tissu0.34169059
121MP0002135_abnormal_kidney_morphology0.34051275
122MP0005166_decreased_susceptibility_to0.33451904
123MP0003075_altered_response_to0.33231391
124MP0002822_catalepsy0.32630795
125MP0005464_abnormal_platelet_physiology0.31447300
126MP0000538_abnormal_urinary_bladder0.30884499
127MP0009115_abnormal_fat_cell0.29996378
128MP0005248_abnormal_Harderian_gland0.29994491
129MP0003724_increased_susceptibility_to0.28801288
130MP0002970_abnormal_white_adipose0.27558045
131MP0009384_cardiac_valve_regurgitation0.26826489
132MP0002837_dystrophic_cardiac_calcinosis0.25795936
133MP0000579_abnormal_nail_morphology0.25000506
134MP0003436_decreased_susceptibility_to0.23781854
135MP0010234_abnormal_vibrissa_follicle0.23029983
136MP0001845_abnormal_inflammatory_respons0.22703245
137MP0005167_abnormal_blood-brain_barrier0.22701055
138MP0000249_abnormal_blood_vessel0.22031895
139MP0001853_heart_inflammation0.21638420
140MP0003959_abnormal_lean_body0.20912266

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.21473522
2Intrahepatic cholestasis (HP:0001406)6.99171780
3Deep venous thrombosis (HP:0002625)6.68831529
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44288553
5Xanthomatosis (HP:0000991)5.97130009
6Hypobetalipoproteinemia (HP:0003563)5.88535314
7Prolonged partial thromboplastin time (HP:0003645)5.83345946
8Hyperlipoproteinemia (HP:0010980)5.00288653
9Complement deficiency (HP:0004431)4.80822575
10Hyperglycinemia (HP:0002154)4.79685595
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.78018230
12Hyperammonemia (HP:0001987)4.76643702
13Hyperglycinuria (HP:0003108)4.70663798
14Ketosis (HP:0001946)4.53853912
15Abnormality of serine family amino acid metabolism (HP:0010894)4.51471885
16Abnormality of glycine metabolism (HP:0010895)4.51471885
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.44293393
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.44098075
19Joint hemorrhage (HP:0005261)4.35196327
20Hypolipoproteinemia (HP:0010981)4.35105224
21Epidermoid cyst (HP:0200040)4.17882513
22Abnormality of methionine metabolism (HP:0010901)4.12727427
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.96424069
24Abnormality of the common coagulation pathway (HP:0010990)3.94849156
25Fat malabsorption (HP:0002630)3.94562173
26Abnormality of pyrimidine metabolism (HP:0004353)3.93124041
27Hypoglycemic coma (HP:0001325)3.77119210
28Hypoalphalipoproteinemia (HP:0003233)3.74931855
29Gout (HP:0001997)3.61944141
30Abnormality of fatty-acid metabolism (HP:0004359)3.58292649
31Abnormality of nucleobase metabolism (HP:0010932)3.52241423
32Conjugated hyperbilirubinemia (HP:0002908)3.49813825
33Ketoacidosis (HP:0001993)3.48778073
34Abnormality of complement system (HP:0005339)3.46412545
35Delayed CNS myelination (HP:0002188)3.46318997
36Abnormality of the intrinsic pathway (HP:0010989)3.32313496
37Abnormality of purine metabolism (HP:0004352)3.31800114
38Abnormality of serum amino acid levels (HP:0003112)3.28299010
39Hypercholesterolemia (HP:0003124)3.27167005
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23351926
41Hyperbilirubinemia (HP:0002904)3.20424543
42Metabolic acidosis (HP:0001942)2.98474301
43Hepatocellular carcinoma (HP:0001402)2.97009421
44Steatorrhea (HP:0002570)2.96840241
45Nephritis (HP:0000123)2.94835897
46Vascular calcification (HP:0004934)2.89883581
47Lethargy (HP:0001254)2.84642738
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83411600
49Dicarboxylic aciduria (HP:0003215)2.83411600
50Arthropathy (HP:0003040)2.75420148
51Spastic diplegia (HP:0001264)2.71015123
52Myocardial infarction (HP:0001658)2.63051383
53Hypochromic microcytic anemia (HP:0004840)2.62492372
54Alkalosis (HP:0001948)2.62340287
55Spontaneous abortion (HP:0005268)2.61798385
56Generalized aminoaciduria (HP:0002909)2.61727796
57Pancreatic islet-cell hyperplasia (HP:0004510)2.61370963
58Proximal tubulopathy (HP:0000114)2.58233859
59Cardiovascular calcification (HP:0011915)2.55734561
60Osteomalacia (HP:0002749)2.54315521
61Malnutrition (HP:0004395)2.53861108
62Hyperuricemia (HP:0002149)2.52876462
63Increased purine levels (HP:0004368)2.52876462
64Irritability (HP:0000737)2.52626943
65Skin nodule (HP:0200036)2.51264299
66Cerebral edema (HP:0002181)2.51013457
67Systemic lupus erythematosus (HP:0002725)2.47087641
68Neonatal onset (HP:0003623)2.46158095
69Fair hair (HP:0002286)2.42239239
70Enlarged kidneys (HP:0000105)2.36542560
71Hypoglycemic seizures (HP:0002173)2.34818133
72Vomiting (HP:0002013)2.33204967
73Rickets (HP:0002748)2.31894476
74Gingival bleeding (HP:0000225)2.29751598
75Abnormality of proline metabolism (HP:0010907)2.27247495
76Hydroxyprolinuria (HP:0003080)2.27247495
77Reduced antithrombin III activity (HP:0001976)2.25854423
78Late onset (HP:0003584)2.25666547
79Sensorimotor neuropathy (HP:0007141)2.23851074
80Mitral stenosis (HP:0001718)2.22405861
81Acanthocytosis (HP:0001927)2.19328960
82Abnormal gallbladder morphology (HP:0012437)2.18829648
83Abnormal biliary tract physiology (HP:0012439)2.18741019
84Bile duct proliferation (HP:0001408)2.18741019
85Hyperphosphaturia (HP:0003109)2.18156793
86Glycosuria (HP:0003076)2.17044806
87Abnormality of urine glucose concentration (HP:0011016)2.17044806
88Pancreatitis (HP:0001733)2.16721551
89Glomerulonephritis (HP:0000099)2.14913953
90Cholelithiasis (HP:0001081)2.13461714
91Abnormal enzyme/coenzyme activity (HP:0012379)2.11133840
92Purpura (HP:0000979)2.10924355
93Esophageal varix (HP:0002040)2.10502950
94Abnormal gallbladder physiology (HP:0012438)2.06364996
95Cholecystitis (HP:0001082)2.06364996
96Hypothermia (HP:0002045)2.05386911
97Abnormality of the pancreatic islet cells (HP:0006476)2.04363607
98Abnormality of endocrine pancreas physiology (HP:0012093)2.04363607
99Opisthotonus (HP:0002179)2.01774309
100Brushfield spots (HP:0001088)1.99800589
101Hypophosphatemic rickets (HP:0004912)1.98925761
102Recurrent gram-negative bacterial infections (HP:0005420)1.93699282
103Abnormal cartilage morphology (HP:0002763)1.93188371
104Hyperinsulinemic hypoglycemia (HP:0000825)1.92871299
105Thrombophlebitis (HP:0004418)1.92677995
106Hepatoblastoma (HP:0002884)1.89355583
107Amyloidosis (HP:0011034)1.88484672
108Pulmonary embolism (HP:0002204)1.88234039
109Poikilocytosis (HP:0004447)1.87807334
110Confusion (HP:0001289)1.87752935
111Bifid scrotum (HP:0000048)1.87602666
112Menorrhagia (HP:0000132)1.87101993
113Abnormality of alkaline phosphatase activity (HP:0004379)1.86956347
114Nephrolithiasis (HP:0000787)1.86245542
115Abnormality of vitamin metabolism (HP:0100508)1.85188512
116Abnormality of the gallbladder (HP:0005264)1.83801106
117Elevated alkaline phosphatase (HP:0003155)1.80474562
118Hemorrhage of the eye (HP:0011885)1.79237174
119Retinal atrophy (HP:0001105)1.77812135
120Facial shape deformation (HP:0011334)1.70643760
121Potter facies (HP:0002009)1.70643760
122Vaginal fistula (HP:0004320)1.69617252
123Abnormal urine phosphate concentration (HP:0012599)1.68756445
124Increased serum pyruvate (HP:0003542)1.64334098
125Hyperglycemia (HP:0003074)1.57624362
126Symptomatic seizures (HP:0011145)1.57343451
127Neoplasm of the liver (HP:0002896)1.54776494
128Status epilepticus (HP:0002133)1.54471586

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.71142311
2FGFR44.43822090
3SIK14.19224273
4ERN13.82242343
5ERBB42.94426683
6INSRR2.71153782
7BMPR1B2.58343538
8CASK2.55232424
9WNK32.44997753
10TAOK32.39310910
11WNK42.30729202
12NTRK32.20253108
13MST1R2.17128215
14PKN22.15450843
15TNIK2.00248297
16ZAK1.98844178
17MAPK111.96049313
18MAP2K41.89373434
19FLT31.83734716
20ADRBK21.80986172
21OXSR11.80098850
22STK38L1.80098203
23PIK3CA1.73319674
24MAP4K21.72358760
25DYRK21.70612781
26LATS11.61644338
27ACVR1B1.61514073
28BCR1.57824147
29ABL21.45670347
30PIK3CG1.40366136
31TRIB31.39940441
32TYK21.36402935
33PINK11.34312137
34GRK61.33678924
35PTK61.33496509
36DAPK21.27689934
37FGFR11.22571743
38STK161.21619192
39MAP3K41.20600597
40NLK1.20235622
41FRK1.17627796
42NTRK21.17148539
43NEK91.16514155
44MAP3K71.16104180
45KDR1.15059916
46FGFR21.13916063
47NUAK11.09817419
48JAK21.07602104
49MET1.06492517
50PRKAA21.06385568
51MAPK151.00671184
52MKNK21.00587028
53PDK41.00485178
54PDK31.00485178
55NEK10.99348834
56TYRO30.98004532
57MARK10.97917364
58CSNK1D0.94466051
59ERBB20.94455901
60PLK30.94100324
61MAP3K100.93701334
62PRKCZ0.91170454
63DYRK1B0.90280432
64CAMK1G0.89392949
65PASK0.88967885
66CSNK1E0.88922426
67CSNK1G20.88159322
68MAP2K30.85877346
69GSK3A0.85752293
70SGK30.83720721
71CDK60.82888998
72SGK2230.82126381
73SGK4940.82126381
74MAP3K30.82117724
75MAPK40.81307967
76PRKACA0.79414992
77CSNK1A1L0.77169915
78PRKAA10.75761857
79PRKG10.74841190
80EPHB10.73599738
81PRKCE0.73267020
82MAP3K140.72981046
83PRKACG0.72143195
84SGK20.70286920
85EIF2AK10.67113688
86MAPK130.66276649
87SGK10.66230841
88TIE10.65016871
89PTK20.64961364
90MAP3K110.62763637
91MAPK120.62580581
92TBK10.61971585
93JAK10.61257892
94WNK10.60935322
95CSK0.60647985
96MAP2K60.59131516
97PLK20.58841551
98CSNK1A10.58808686
99AKT30.58737644
100CAMK2G0.55632287
101PDK20.55601863
102PRKACB0.55289403
103STK30.52535010
104IRAK30.51372233
105TSSK60.50801178
106CDK40.50506442
107CSNK1G10.49294736
108RPS6KA30.48702967
109STK390.48388779
110RIPK10.47696540
111PRKCB0.46306518
112BRSK20.46163155
113MAPK70.45910317
114CSNK2A10.45879681
115PDPK10.45547595
116CAMKK20.44940616
117EIF2AK30.44397503
118ICK0.43832981
119PRKDC0.43818660
120MTOR0.43809463
121PBK0.43620732
122CAMK1D0.42574937
123TGFBR20.42298841
124CSNK2A20.41489121
125FER0.41426802
126NEK20.41373987
127ATM0.40868356
128MKNK10.40433500
129DYRK1A0.40258781
130TAOK20.38827858
131GRK10.36705592
132EPHA30.36595313
133STK380.36276986
134PHKG10.36022508
135PHKG20.36022508
136PRKCQ0.35978277
137IGF1R0.35942615
138RPS6KB10.35444830
139EPHA20.35351018
140ALK0.35295770
141SIK20.34980100
142FGFR30.34305961
143PRKCG0.33580066
144STK110.32529912
145CSF1R0.30872892
146CAMK2D0.30787425
147BMX0.29990448
148MAP3K50.28284481
149EPHA40.27915863
150IRAK20.27665724
151GSK3B0.27619357
152IRAK10.27342083
153LATS20.27089588
154EGFR0.27009857
155MAP2K10.26744685
156PDK10.25775073
157CAMK40.24428867
158PRKCA0.24053139
159MAP2K20.22782871
160PAK30.22416888
161CSNK1G30.21166416

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.24912335
2Nitrogen metabolism_Homo sapiens_hsa009103.45580644
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44694884
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32800359
5Arginine biosynthesis_Homo sapiens_hsa002202.95683091
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81679030
7Tryptophan metabolism_Homo sapiens_hsa003802.72216349
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60840861
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55774576
10Fatty acid degradation_Homo sapiens_hsa000712.51922405
11* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51210488
12Complement and coagulation cascades_Homo sapiens_hsa046102.44731985
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38674091
14Butanoate metabolism_Homo sapiens_hsa006502.38613745
15Propanoate metabolism_Homo sapiens_hsa006402.13414014
16* Peroxisome_Homo sapiens_hsa041462.12890517
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06048149
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85773725
19Histidine metabolism_Homo sapiens_hsa003401.85714727
20Chemical carcinogenesis_Homo sapiens_hsa052041.84764187
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82890409
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.82352799
23Fatty acid metabolism_Homo sapiens_hsa012121.81375437
24PPAR signaling pathway_Homo sapiens_hsa033201.81007189
25beta-Alanine metabolism_Homo sapiens_hsa004101.78705877
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78587745
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76690205
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.73664957
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71713045
30Selenocompound metabolism_Homo sapiens_hsa004501.64348028
31Retinol metabolism_Homo sapiens_hsa008301.59477167
32Phenylalanine metabolism_Homo sapiens_hsa003601.54864171
33Caffeine metabolism_Homo sapiens_hsa002321.54817757
34Pyruvate metabolism_Homo sapiens_hsa006201.54657379
35Bile secretion_Homo sapiens_hsa049761.53017682
36Staphylococcus aureus infection_Homo sapiens_hsa051501.48543775
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.42160678
38Sulfur metabolism_Homo sapiens_hsa009201.38566003
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35867995
40Tyrosine metabolism_Homo sapiens_hsa003501.35556862
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33223791
42Biosynthesis of amino acids_Homo sapiens_hsa012301.30817959
43Starch and sucrose metabolism_Homo sapiens_hsa005001.28792358
44Carbon metabolism_Homo sapiens_hsa012001.27029160
45Folate biosynthesis_Homo sapiens_hsa007901.26818807
46Fatty acid elongation_Homo sapiens_hsa000621.23746185
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17089940
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15445951
49Steroid biosynthesis_Homo sapiens_hsa001001.13958813
50Arginine and proline metabolism_Homo sapiens_hsa003301.09354027
51ABC transporters_Homo sapiens_hsa020101.08239988
52Fat digestion and absorption_Homo sapiens_hsa049751.03953259
53Vitamin digestion and absorption_Homo sapiens_hsa049771.01764244
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.97653103
55Sulfur relay system_Homo sapiens_hsa041220.91850604
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90095614
57One carbon pool by folate_Homo sapiens_hsa006700.86353606
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83371931
59Glutathione metabolism_Homo sapiens_hsa004800.82794986
60Vitamin B6 metabolism_Homo sapiens_hsa007500.82578583
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81349337
62* Lysine degradation_Homo sapiens_hsa003100.79709781
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.75514080
64Glycerolipid metabolism_Homo sapiens_hsa005610.71168687
65Pentose phosphate pathway_Homo sapiens_hsa000300.60972127
66* Metabolic pathways_Homo sapiens_hsa011000.49484858
67Fatty acid biosynthesis_Homo sapiens_hsa000610.42211454
68Fructose and mannose metabolism_Homo sapiens_hsa000510.35706738
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28816955
70Galactose metabolism_Homo sapiens_hsa000520.26856410
71Prion diseases_Homo sapiens_hsa050200.25821811
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23115174
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22692044
74Protein export_Homo sapiens_hsa030600.19968206
75Insulin resistance_Homo sapiens_hsa049310.19256811
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18062029
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.15997730
78Linoleic acid metabolism_Homo sapiens_hsa005910.15020456
79N-Glycan biosynthesis_Homo sapiens_hsa005100.11116820
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.09799779
81Ether lipid metabolism_Homo sapiens_hsa005650.09437350
82Serotonergic synapse_Homo sapiens_hsa047260.09229286
83Glucagon signaling pathway_Homo sapiens_hsa049220.06807432
84Phototransduction_Homo sapiens_hsa047440.03308231
85Pertussis_Homo sapiens_hsa051330.02388237
86AMPK signaling pathway_Homo sapiens_hsa041520.01234645
87Sphingolipid metabolism_Homo sapiens_hsa006000.00722253
88Pyrimidine metabolism_Homo sapiens_hsa00240-0.2470458
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2356992
90African trypanosomiasis_Homo sapiens_hsa05143-0.2324221
91Other glycan degradation_Homo sapiens_hsa00511-0.2176199
92Bladder cancer_Homo sapiens_hsa05219-0.2069713
93Hepatitis C_Homo sapiens_hsa05160-0.1958954
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1800601
95Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1674111
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1647305
97Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1606549
98Regulation of autophagy_Homo sapiens_hsa04140-0.1554837
99Mineral absorption_Homo sapiens_hsa04978-0.1492320
100Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1474449
101Insulin signaling pathway_Homo sapiens_hsa04910-0.1425165
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1399325
103Protein digestion and absorption_Homo sapiens_hsa04974-0.1348746
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1125481
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1040789
106Type II diabetes mellitus_Homo sapiens_hsa04930-0.0841852
107Nicotine addiction_Homo sapiens_hsa05033-0.0771493
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0639606
109Circadian rhythm_Homo sapiens_hsa04710-0.0607007
110GABAergic synapse_Homo sapiens_hsa04727-0.0594881
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0532091
112Renin-angiotensin system_Homo sapiens_hsa04614-0.0522634
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0481866
114Insulin secretion_Homo sapiens_hsa04911-0.0217537

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