PIPSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.39477415
2behavioral response to nicotine (GO:0035095)5.24654955
3ATP synthesis coupled proton transport (GO:0015986)5.00648548
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.00648548
5viral transcription (GO:0019083)4.41992639
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.41639357
7translational termination (GO:0006415)4.38389156
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.79882041
9sequestering of actin monomers (GO:0042989)3.68414915
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.64224773
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.58402930
12protein complex biogenesis (GO:0070271)3.57320968
13cotranslational protein targeting to membrane (GO:0006613)3.57313063
14electron transport chain (GO:0022900)3.51634264
15respiratory electron transport chain (GO:0022904)3.51007534
16neuron fate determination (GO:0048664)3.50419281
17protein targeting to ER (GO:0045047)3.50404432
18translational elongation (GO:0006414)3.47208535
19G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47118865
20chaperone-mediated protein transport (GO:0072321)3.45376425
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.44184343
22NADH dehydrogenase complex assembly (GO:0010257)3.44184343
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44184343
24cellular protein complex disassembly (GO:0043624)3.43180177
25ribosomal small subunit assembly (GO:0000028)3.36954446
26epithelial cilium movement (GO:0003351)3.36510368
27sperm motility (GO:0030317)3.35298653
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.33243705
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.33243705
30regulation of translation, ncRNA-mediated (GO:0045974)3.33243705
31establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31855958
32protein localization to cilium (GO:0061512)3.30326571
33mitochondrial respiratory chain complex assembly (GO:0033108)3.29821876
34nonmotile primary cilium assembly (GO:0035058)3.26679100
35positive regulation of meiosis (GO:0045836)3.25843197
36cilium movement (GO:0003341)3.24900961
37regulation of mesenchymal cell apoptotic process (GO:2001053)3.24741222
38negative regulation of transcription regulatory region DNA binding (GO:2000678)3.24636995
39protein localization to endoplasmic reticulum (GO:0070972)3.23249960
40axonemal dynein complex assembly (GO:0070286)3.12546106
41indolalkylamine metabolic process (GO:0006586)3.12099679
42regulation of sarcomere organization (GO:0060297)3.08910722
43viral life cycle (GO:0019058)3.07003080
44positive regulation of gastrulation (GO:2000543)3.05919274
45midbrain development (GO:0030901)3.05729823
46postsynaptic membrane organization (GO:0001941)3.05369666
47positive regulation of meiotic cell cycle (GO:0051446)3.05298772
48cellular response to nicotine (GO:0071316)3.04701138
49reflex (GO:0060004)2.97499236
50indole-containing compound catabolic process (GO:0042436)2.96614988
51indolalkylamine catabolic process (GO:0046218)2.96614988
52tryptophan catabolic process (GO:0006569)2.96614988
53protein complex disassembly (GO:0043241)2.95464424
54cellular ketone body metabolic process (GO:0046950)2.94789991
55protein-cofactor linkage (GO:0018065)2.90205048
56spinal cord motor neuron differentiation (GO:0021522)2.89984383
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89615850
58neuron fate specification (GO:0048665)2.88774417
59NAD biosynthetic process (GO:0009435)2.87033699
60kynurenine metabolic process (GO:0070189)2.86905056
61detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86265294
62maturation of SSU-rRNA (GO:0030490)2.83506881
63regulation of posttranscriptional gene silencing (GO:0060147)2.83082046
64regulation of gene silencing by miRNA (GO:0060964)2.83082046
65regulation of gene silencing by RNA (GO:0060966)2.83082046
66macromolecular complex disassembly (GO:0032984)2.82285902
67signal peptide processing (GO:0006465)2.81369680
68translational initiation (GO:0006413)2.80396056
69termination of RNA polymerase III transcription (GO:0006386)2.76521804
70transcription elongation from RNA polymerase III promoter (GO:0006385)2.76521804
71rRNA modification (GO:0000154)2.76392864
72acrosome reaction (GO:0007340)2.76212970
73cell differentiation in spinal cord (GO:0021515)2.74457358
74ATP biosynthetic process (GO:0006754)2.72767022
75microtubule depolymerization (GO:0007019)2.72305454
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69826482
77hydrogen ion transmembrane transport (GO:1902600)2.69775194
78regulation of female gonad development (GO:2000194)2.69055164
79gamma-aminobutyric acid transport (GO:0015812)2.68243230
80mannosylation (GO:0097502)2.66278428
81protein polyglutamylation (GO:0018095)2.64986576
82response to pheromone (GO:0019236)2.64457891
83cell proliferation in forebrain (GO:0021846)2.61160789
84regulation of cilium movement (GO:0003352)2.60679251
85ketone body metabolic process (GO:1902224)2.60103257
86axoneme assembly (GO:0035082)2.58139540
87ribosomal large subunit biogenesis (GO:0042273)2.58048222
88ribosomal small subunit biogenesis (GO:0042274)2.57386921
89proton transport (GO:0015992)2.56937660
90dendritic spine morphogenesis (GO:0060997)2.56552373
91rRNA methylation (GO:0031167)2.56072844
92spinal cord association neuron differentiation (GO:0021527)2.55929670
93detection of light stimulus involved in sensory perception (GO:0050962)2.55201236
94detection of light stimulus involved in visual perception (GO:0050908)2.55201236
95tryptophan metabolic process (GO:0006568)2.55056653
96preassembly of GPI anchor in ER membrane (GO:0016254)2.53876599
97epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.52307724
98protein neddylation (GO:0045116)2.51779592
99hydrogen transport (GO:0006818)2.50721876
100cilium organization (GO:0044782)2.48976100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59552702
2VDR_22108803_ChIP-Seq_LS180_Human3.33429572
3ZNF274_21170338_ChIP-Seq_K562_Hela2.85564903
4CBX2_27304074_Chip-Seq_ESCs_Mouse2.71099067
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50672235
6CTBP1_25329375_ChIP-Seq_LNCAP_Human2.41941358
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35605398
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28907575
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.25442984
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22104699
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14120796
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.12256899
13GBX2_23144817_ChIP-Seq_PC3_Human2.10713540
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.09605538
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00006047
16TAF15_26573619_Chip-Seq_HEK293_Human1.99456801
17POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.93779822
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93779822
19FUS_26573619_Chip-Seq_HEK293_Human1.89598004
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85771687
21RNF2_27304074_Chip-Seq_NSC_Mouse1.84980807
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84807813
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.83142445
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82526409
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.76973015
26P300_19829295_ChIP-Seq_ESCs_Human1.73184787
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.71769914
28EWS_26573619_Chip-Seq_HEK293_Human1.70477670
29REST_21632747_ChIP-Seq_MESCs_Mouse1.68546199
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63903044
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60275524
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59733105
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.58744483
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56398120
35AR_21572438_ChIP-Seq_LNCaP_Human1.55291189
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50414901
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48617801
38ER_23166858_ChIP-Seq_MCF-7_Human1.46730648
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46301554
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.46246678
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45742010
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43088381
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.42209584
44DROSHA_22980978_ChIP-Seq_HELA_Human1.41838089
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40904621
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39250046
47BCAT_22108803_ChIP-Seq_LS180_Human1.36547408
48AR_25329375_ChIP-Seq_VCAP_Human1.35961448
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35163597
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35132990
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33848590
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32810870
53IGF1R_20145208_ChIP-Seq_DFB_Human1.31673328
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.30612807
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30451966
56CBP_20019798_ChIP-Seq_JUKART_Human1.28901690
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28901690
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28312475
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28312475
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28303123
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.23707742
62MYC_18940864_ChIP-ChIP_HL60_Human1.23288093
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23036112
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22776054
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19918349
66SMAD4_21799915_ChIP-Seq_A2780_Human1.19590644
67TP53_22573176_ChIP-Seq_HFKS_Human1.18129269
68TCF4_22108803_ChIP-Seq_LS180_Human1.17550597
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16998067
70* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15966975
71NANOG_19829295_ChIP-Seq_ESCs_Human1.15524306
72SOX2_19829295_ChIP-Seq_ESCs_Human1.15524306
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13981659
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.13981659
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.13470150
76RUNX2_22187159_ChIP-Seq_PCA_Human1.11775559
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.11539208
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10655982
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10187104
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09640875
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09467273
82STAT3_23295773_ChIP-Seq_U87_Human1.08690416
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05886640
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.03867626
85ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03510899
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03226181
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01422521
88* TCF4_23295773_ChIP-Seq_U87_Human1.01225187
89AR_20517297_ChIP-Seq_VCAP_Human1.00332786
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00294085
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99971957
92MYC_19829295_ChIP-Seq_ESCs_Human0.98990168
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.98756528
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.98086988
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97763149
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97292326
97SOX2_16153702_ChIP-ChIP_HESCs_Human0.96095050
98SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95365596
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.95112352
100ERA_21632823_ChIP-Seq_H3396_Human0.94428809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.21416224
2MP0006292_abnormal_olfactory_placode2.91233693
3MP0003136_yellow_coat_color2.76239542
4MP0003880_abnormal_central_pattern2.44842573
5MP0002938_white_spotting2.24260419
6MP0000566_synostosis2.18274674
7MP0001485_abnormal_pinna_reflex2.15519561
8MP0004885_abnormal_endolymph2.08871590
9MP0006072_abnormal_retinal_apoptosis2.06564307
10MP0009745_abnormal_behavioral_response2.05925025
11MP0003878_abnormal_ear_physiology2.05372253
12MP0005377_hearing/vestibular/ear_phenot2.05372253
13MP0004142_abnormal_muscle_tone1.99804934
14MP0000631_abnormal_neuroendocrine_gland1.97457762
15MP0003195_calcinosis1.97388670
16MP0001501_abnormal_sleep_pattern1.95850334
17MP0005423_abnormal_somatic_nervous1.94169298
18MP0001968_abnormal_touch/_nociception1.94067892
19MP0002822_catalepsy1.91614436
20MP0002234_abnormal_pharynx_morphology1.89148050
21MP0006276_abnormal_autonomic_nervous1.86403463
22MP0002735_abnormal_chemical_nociception1.80170813
23MP0003011_delayed_dark_adaptation1.76574370
24MP0002736_abnormal_nociception_after1.73842217
25MP0004133_heterotaxia1.72581642
26MP0005551_abnormal_eye_electrophysiolog1.72123262
27MP0008789_abnormal_olfactory_epithelium1.71073915
28MP0002638_abnormal_pupillary_reflex1.70878374
29MP0001905_abnormal_dopamine_level1.69318633
30MP0001486_abnormal_startle_reflex1.68657696
31MP0000049_abnormal_middle_ear1.68199243
32MP0004742_abnormal_vestibular_system1.67793291
33MP0005410_abnormal_fertilization1.67096882
34MP0005645_abnormal_hypothalamus_physiol1.62539956
35MP0002272_abnormal_nervous_system1.62314101
36MP0000778_abnormal_nervous_system1.57299710
37MP0009046_muscle_twitch1.57024293
38MP0000026_abnormal_inner_ear1.55902856
39MP0005253_abnormal_eye_physiology1.48951400
40MP0002572_abnormal_emotion/affect_behav1.46288378
41MP0002557_abnormal_social/conspecific_i1.43818432
42MP0001293_anophthalmia1.42904559
43MP0002837_dystrophic_cardiac_calcinosis1.42608854
44MP0001440_abnormal_grooming_behavior1.42139645
45MP0001529_abnormal_vocalization1.40302209
46MP0005646_abnormal_pituitary_gland1.39654274
47MP0002064_seizures1.39076474
48MP0000569_abnormal_digit_pigmentation1.37696532
49MP0002733_abnormal_thermal_nociception1.32373338
50MP0003283_abnormal_digestive_organ1.31679104
51MP0008995_early_reproductive_senescence1.31036705
52MP0002876_abnormal_thyroid_physiology1.24224851
53MP0001963_abnormal_hearing_physiology1.24000455
54MP0005499_abnormal_olfactory_system1.23958055
55MP0005394_taste/olfaction_phenotype1.23958055
56MP0002102_abnormal_ear_morphology1.23548853
57MP0003938_abnormal_ear_development1.21831807
58MP0002067_abnormal_sensory_capabilities1.21001875
59MP0001970_abnormal_pain_threshold1.20085234
60MP0001984_abnormal_olfaction1.18835327
61MP0002734_abnormal_mechanical_nocicepti1.18764484
62MP0003937_abnormal_limbs/digits/tail_de1.18749691
63MP0000372_irregular_coat_pigmentation1.17869087
64MP0003698_abnormal_male_reproductive1.15943334
65MP0005084_abnormal_gallbladder_morpholo1.15052265
66MP0003635_abnormal_synaptic_transmissio1.14561964
67MP0004043_abnormal_pH_regulation1.14414874
68MP0002928_abnormal_bile_duct1.13900745
69MP0001346_abnormal_lacrimal_gland1.11968352
70MP0008872_abnormal_physiological_respon1.11809427
71MP0002752_abnormal_somatic_nervous1.11096594
72MP0003718_maternal_effect1.10954971
73MP0010386_abnormal_urinary_bladder1.08530358
74MP0002095_abnormal_skin_pigmentation1.07656640
75MP0009250_abnormal_appendicular_skeleto1.06898485
76MP0008877_abnormal_DNA_methylation1.06610547
77MP0003119_abnormal_digestive_system1.06553892
78MP0002653_abnormal_ependyma_morphology1.04852861
79MP0005195_abnormal_posterior_eye1.03611694
80MP0004145_abnormal_muscle_electrophysio1.03512621
81MP0001348_abnormal_lacrimal_gland1.02035468
82MP0001929_abnormal_gametogenesis1.00314560
83MP0002751_abnormal_autonomic_nervous1.00133126
84MP0004147_increased_porphyrin_level0.97489349
85MP0002277_abnormal_respiratory_mucosa0.95937223
86MP0000955_abnormal_spinal_cord0.95784124
87MP0001188_hyperpigmentation0.95346882
88MP0002210_abnormal_sex_determination0.94615928
89MP0002184_abnormal_innervation0.93608781
90MP0001986_abnormal_taste_sensitivity0.90055733
91MP0002063_abnormal_learning/memory/cond0.88973937
92MP0002249_abnormal_larynx_morphology0.87020144
93MP0005391_vision/eye_phenotype0.83141379
94MP0003646_muscle_fatigue0.80688647
95MP0002882_abnormal_neuron_morphology0.80331232
96MP0009053_abnormal_anal_canal0.80192051
97MP0008961_abnormal_basal_metabolism0.79059631
98MP0000653_abnormal_sex_gland0.77397793
99MP0001286_abnormal_eye_development0.73290014
100MP0005171_absent_coat_pigmentation0.70511576

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)4.43262492
2Congenital, generalized hypertrichosis (HP:0004540)4.32513154
3Pancreatic cysts (HP:0001737)3.82811346
4Nephronophthisis (HP:0000090)3.68303428
5Pancreatic fibrosis (HP:0100732)3.42554903
6Abnormal ciliary motility (HP:0012262)3.35097958
7Genetic anticipation (HP:0003743)3.32053465
8Abnormality of the renal medulla (HP:0100957)3.31522623
9Abnormal number of erythroid precursors (HP:0012131)3.25256962
10True hermaphroditism (HP:0010459)3.24772144
11Abnormality of midbrain morphology (HP:0002418)3.21976440
12Molar tooth sign on MRI (HP:0002419)3.21976440
13Progressive cerebellar ataxia (HP:0002073)3.15095957
14Abnormal respiratory motile cilium morphology (HP:0005938)3.10212838
15Abnormal respiratory epithelium morphology (HP:0012253)3.10212838
16Congenital stationary night blindness (HP:0007642)3.03289381
17Acute necrotizing encephalopathy (HP:0006965)3.00509133
18Abnormality of the renal cortex (HP:0011035)2.95272350
19Retinal dysplasia (HP:0007973)2.94538335
20Abnormality of cells of the erythroid lineage (HP:0012130)2.89884656
21Abnormal respiratory motile cilium physiology (HP:0012261)2.85717610
22Sclerocornea (HP:0000647)2.77479092
23Mitochondrial inheritance (HP:0001427)2.74722840
24Dynein arm defect of respiratory motile cilia (HP:0012255)2.70915832
25Absent/shortened dynein arms (HP:0200106)2.70915832
26Type II lissencephaly (HP:0007260)2.69124396
27Decreased central vision (HP:0007663)2.68893924
28Reticulocytopenia (HP:0001896)2.61900969
29Abolished electroretinogram (ERG) (HP:0000550)2.57850549
30Increased hepatocellular lipid droplets (HP:0006565)2.56921878
31Acute encephalopathy (HP:0006846)2.55523371
32Abnormal drinking behavior (HP:0030082)2.52323594
33Polydipsia (HP:0001959)2.52323594
34Oligodactyly (hands) (HP:0001180)2.51349207
353-Methylglutaconic aciduria (HP:0003535)2.50966136
36Abnormal mitochondria in muscle tissue (HP:0008316)2.46350540
37Bony spicule pigmentary retinopathy (HP:0007737)2.46115140
38Attenuation of retinal blood vessels (HP:0007843)2.45231558
39Increased CSF lactate (HP:0002490)2.42222722
40Hypoplasia of the pons (HP:0012110)2.40114847
41Chronic hepatic failure (HP:0100626)2.39699157
42Tubular atrophy (HP:0000092)2.39689851
43Progressive macrocephaly (HP:0004481)2.37529611
44Medial flaring of the eyebrow (HP:0010747)2.31118138
45Pendular nystagmus (HP:0012043)2.30770829
46Cystic liver disease (HP:0006706)2.29481841
47Rhinitis (HP:0012384)2.29138001
48Lipid accumulation in hepatocytes (HP:0006561)2.28731137
49Decreased circulating renin level (HP:0003351)2.25348127
50Abnormality of the pons (HP:0007361)2.24568935
51Macrocytic anemia (HP:0001972)2.19328770
52Anencephaly (HP:0002323)2.18487024
53Renal Fanconi syndrome (HP:0001994)2.18459822
54Maternal diabetes (HP:0009800)2.18287985
55Optic disc pallor (HP:0000543)2.17863551
56Abnormality of binocular vision (HP:0011514)2.14861852
57Diplopia (HP:0000651)2.14861852
58Gaze-evoked nystagmus (HP:0000640)2.13903770
59Septo-optic dysplasia (HP:0100842)2.12021538
60Cerebellar dysplasia (HP:0007033)2.10965339
61Focal motor seizures (HP:0011153)2.10824985
62Hyperventilation (HP:0002883)2.10207966
63Hepatocellular necrosis (HP:0001404)2.04222860
64Polyuria (HP:0000103)2.01115686
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.96662585
66Optic nerve hypoplasia (HP:0000609)1.96613975
67Abnormal number of incisors (HP:0011064)1.95338806
68Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.93968277
69Abnormal rod and cone electroretinograms (HP:0008323)1.93858933
70Bilateral microphthalmos (HP:0007633)1.93084176
71Hepatic necrosis (HP:0002605)1.92711053
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91379227
73Patellar aplasia (HP:0006443)1.90410355
74Broad-based gait (HP:0002136)1.86973170
75Anophthalmia (HP:0000528)1.86747309
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86553675
77Abnormality of alanine metabolism (HP:0010916)1.86553675
78Hyperalaninemia (HP:0003348)1.86553675
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84287802
80Methylmalonic acidemia (HP:0002912)1.84167951
81Congenital hepatic fibrosis (HP:0002612)1.83861198
82Aplasia/Hypoplasia of the patella (HP:0006498)1.83274977
83Renal cortical cysts (HP:0000803)1.82261856
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.81630368
85Pallor (HP:0000980)1.81472731
86Chronic sinusitis (HP:0011109)1.78615060
87Keratoconus (HP:0000563)1.77422903
88Increased corneal curvature (HP:0100692)1.77422903
89Nonprogressive disorder (HP:0003680)1.77300108
90Severe visual impairment (HP:0001141)1.74927995
91Male pseudohermaphroditism (HP:0000037)1.72506464
92Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71161427
93Abnormality of the labia minora (HP:0012880)1.71146873
94Abnormal biliary tract physiology (HP:0012439)1.70316699
95Bile duct proliferation (HP:0001408)1.70316699
96Myokymia (HP:0002411)1.69611917
97Methylmalonic aciduria (HP:0012120)1.69323035
98Abnormal urine output (HP:0012590)1.68540417
99Abnormality of macular pigmentation (HP:0008002)1.68179698
100Thyroid-stimulating hormone excess (HP:0002925)1.68116059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.83243437
2TLK13.50440729
3ADRBK23.12260578
4INSRR3.01155169
5PNCK2.53348046
6VRK22.42757832
7CASK2.39141421
8ZAK2.30146502
9BMPR1B2.29697855
10WNK32.26805449
11MAP4K22.06464427
12GRK11.92121845
13NUAK11.88658240
14MAPK151.87216456
15VRK11.73944548
16TXK1.67129409
17PINK11.66623685
18CDK191.65311441
19SIK21.62941849
20PASK1.62610217
21DYRK21.61937578
22STK161.56851697
23TAF11.48676872
24OXSR11.42987532
25NME11.40923056
26BUB11.40040480
27MAP3K41.36932400
28EPHB21.35018960
29NEK21.32454881
30TNIK1.31673468
31WNK41.29253868
32CDC71.28555835
33ACVR1B1.28405471
34PLK41.26380732
35ADRBK11.25724560
36MAPK131.25565649
37NTRK31.21422457
38PRKCG1.19540264
39TAOK31.14828638
40MKNK21.07227365
41TGFBR11.06588657
42PRKCE0.97173473
43MKNK10.96401806
44NTRK20.92062974
45STK390.92059254
46PHKG10.91452427
47PHKG20.91452427
48KIT0.90968976
49BCR0.90236286
50STK38L0.89886271
51MARK10.86127591
52WEE10.79073004
53MAP2K20.73980337
54TIE10.73210491
55DAPK20.72814244
56MAP2K70.72500943
57CDK30.68388791
58FGFR20.62193688
59CDK80.61988657
60SRPK10.61578356
61BCKDK0.61251414
62MUSK0.60219517
63PKN10.60097707
64PLK20.60082398
65CHUK0.59569527
66MAPKAPK50.55882816
67PRKACA0.55708181
68EPHA30.55593014
69RPS6KA50.53326573
70OBSCN0.53037019
71TNK20.52283116
72PAK30.51277248
73DYRK30.50948172
74PRKG10.50918849
75GRK70.50728166
76CAMK1G0.47968037
77CSNK1A10.47913919
78MST40.46978176
79EPHA40.46223177
80PLK30.44843791
81CSNK2A10.43900749
82CAMK2A0.43540009
83PLK10.43319711
84CAMK10.42186008
85CAMK1D0.40547796
86MARK30.40291870
87CSNK1G20.38823472
88CHEK20.37483707
89SGK10.37383876
90PRKCA0.36562741
91IKBKB0.34280262
92ERBB20.33291164
93PRKACB0.33203685
94MAP2K60.32619166
95DDR20.32425304
96CSNK2A20.31698404
97IRAK10.31190672
98UHMK10.31152113
99PRKCZ0.30631639
100DYRK1A0.29803905

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.13582207
2Oxidative phosphorylation_Homo sapiens_hsa001904.04382462
3Parkinsons disease_Homo sapiens_hsa050123.37723306
4Nicotine addiction_Homo sapiens_hsa050332.70883068
5Huntingtons disease_Homo sapiens_hsa050162.44870281
6Cardiac muscle contraction_Homo sapiens_hsa042602.37218548
7Alzheimers disease_Homo sapiens_hsa050102.35594953
8RNA polymerase_Homo sapiens_hsa030202.16139568
9Phototransduction_Homo sapiens_hsa047442.04488908
10Protein export_Homo sapiens_hsa030601.99583070
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98314034
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.96100652
13Proteasome_Homo sapiens_hsa030501.96041354
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91807041
15Homologous recombination_Homo sapiens_hsa034401.91202619
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83782421
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81829148
18Morphine addiction_Homo sapiens_hsa050321.77998590
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71141441
20Butanoate metabolism_Homo sapiens_hsa006501.65458762
21Selenocompound metabolism_Homo sapiens_hsa004501.64801214
22Taste transduction_Homo sapiens_hsa047421.63432277
23Linoleic acid metabolism_Homo sapiens_hsa005911.61838770
24GABAergic synapse_Homo sapiens_hsa047271.47653941
25Tryptophan metabolism_Homo sapiens_hsa003801.41505286
26Nitrogen metabolism_Homo sapiens_hsa009101.40429055
27Basal transcription factors_Homo sapiens_hsa030221.39629348
28Olfactory transduction_Homo sapiens_hsa047401.29287683
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26585767
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25658879
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.20378080
32Circadian entrainment_Homo sapiens_hsa047131.18605459
33Glutamatergic synapse_Homo sapiens_hsa047241.17038820
34Serotonergic synapse_Homo sapiens_hsa047261.15311619
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09445805
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05622498
37Fanconi anemia pathway_Homo sapiens_hsa034601.05504822
38Cocaine addiction_Homo sapiens_hsa050301.03396020
39Asthma_Homo sapiens_hsa053100.98735873
40Insulin secretion_Homo sapiens_hsa049110.98256646
41Caffeine metabolism_Homo sapiens_hsa002320.97177346
42Basal cell carcinoma_Homo sapiens_hsa052170.95546972
43RNA degradation_Homo sapiens_hsa030180.92087118
44Retinol metabolism_Homo sapiens_hsa008300.91110097
45Purine metabolism_Homo sapiens_hsa002300.88353375
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88043664
47Chemical carcinogenesis_Homo sapiens_hsa052040.87684982
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.86192356
49Sulfur relay system_Homo sapiens_hsa041220.86028458
50Mismatch repair_Homo sapiens_hsa034300.85383433
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.81301507
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80407655
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80404925
54Arachidonic acid metabolism_Homo sapiens_hsa005900.79239722
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77306265
56Ether lipid metabolism_Homo sapiens_hsa005650.76590529
57One carbon pool by folate_Homo sapiens_hsa006700.75964478
58Propanoate metabolism_Homo sapiens_hsa006400.75801006
59Hedgehog signaling pathway_Homo sapiens_hsa043400.73993357
60Nucleotide excision repair_Homo sapiens_hsa034200.73895299
61Graft-versus-host disease_Homo sapiens_hsa053320.72505780
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70957210
63Cholinergic synapse_Homo sapiens_hsa047250.69603591
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67708925
65Calcium signaling pathway_Homo sapiens_hsa040200.66839504
66Collecting duct acid secretion_Homo sapiens_hsa049660.65493406
67Type I diabetes mellitus_Homo sapiens_hsa049400.64716704
68Vitamin digestion and absorption_Homo sapiens_hsa049770.64173807
69Pyrimidine metabolism_Homo sapiens_hsa002400.63730760
70Allograft rejection_Homo sapiens_hsa053300.61798587
71Peroxisome_Homo sapiens_hsa041460.61560611
72Autoimmune thyroid disease_Homo sapiens_hsa053200.60651520
73beta-Alanine metabolism_Homo sapiens_hsa004100.59691178
74Salivary secretion_Homo sapiens_hsa049700.58543982
75Spliceosome_Homo sapiens_hsa030400.58165088
76Dopaminergic synapse_Homo sapiens_hsa047280.57762769
77Metabolic pathways_Homo sapiens_hsa011000.56394579
78Gastric acid secretion_Homo sapiens_hsa049710.55595821
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54159985
80Ovarian steroidogenesis_Homo sapiens_hsa049130.53545880
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52665002
82Amphetamine addiction_Homo sapiens_hsa050310.51579559
83cAMP signaling pathway_Homo sapiens_hsa040240.44092637
84RNA transport_Homo sapiens_hsa030130.43327184
85Fat digestion and absorption_Homo sapiens_hsa049750.43188896
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42210375
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40566197
88Oxytocin signaling pathway_Homo sapiens_hsa049210.38949886
89Base excision repair_Homo sapiens_hsa034100.37804307
90ABC transporters_Homo sapiens_hsa020100.37391878
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.36895654
92Primary immunodeficiency_Homo sapiens_hsa053400.36884769
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36647026
94Rheumatoid arthritis_Homo sapiens_hsa053230.34445345
95Antigen processing and presentation_Homo sapiens_hsa046120.33989513
96DNA replication_Homo sapiens_hsa030300.33276203
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31227902
98Glycerolipid metabolism_Homo sapiens_hsa005610.29900987
99Regulation of autophagy_Homo sapiens_hsa041400.29432361
100Renin secretion_Homo sapiens_hsa049240.29166550

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