PIRT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of temperature stimulus involved in sensory perception of pain (GO:0050965)8.33855483
2detection of temperature stimulus involved in sensory perception (GO:0050961)8.33855483
3detection of temperature stimulus (GO:0016048)8.33269441
4neurofilament cytoskeleton organization (GO:0060052)7.91807762
5neuronal action potential (GO:0019228)6.65358095
6negative regulation of dendrite morphogenesis (GO:0050774)6.55611996
7axon ensheathment in central nervous system (GO:0032291)6.38728590
8central nervous system myelination (GO:0022010)6.38728590
9regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)5.97834301
10peripheral nervous system neuron development (GO:0048935)5.80739644
11response to pain (GO:0048265)5.48367785
12cell migration in hindbrain (GO:0021535)5.12388085
13cellular potassium ion homeostasis (GO:0030007)5.11097777
14postsynaptic membrane organization (GO:0001941)5.08075640
15behavioral response to pain (GO:0048266)5.04260786
16membrane depolarization during action potential (GO:0086010)4.95663520
17urinary tract smooth muscle contraction (GO:0014848)4.91821243
18locomotory exploration behavior (GO:0035641)4.81419786
19L-amino acid import (GO:0043092)4.70530282
20negative regulation of calcium ion transport into cytosol (GO:0010523)4.69384498
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.65306654
22sodium ion export (GO:0071436)4.61820535
23positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.57624608
24one-carbon compound transport (GO:0019755)4.55130222
25proline transport (GO:0015824)4.52391692
26presynaptic membrane assembly (GO:0097105)4.51578944
27enteric nervous system development (GO:0048484)4.48252217
28response to water (GO:0009415)4.45953281
29presynaptic membrane organization (GO:0097090)4.38975580
30negative regulation of dendrite development (GO:2000171)4.29970485
31hyperosmotic salinity response (GO:0042538)4.22513534
32astrocyte differentiation (GO:0048708)4.21084988
33neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.19822301
34potassium ion import (GO:0010107)4.18512078
35negative regulation of microtubule polymerization (GO:0031115)4.17946307
36synaptic vesicle docking involved in exocytosis (GO:0016081)4.15393057
37neuronal ion channel clustering (GO:0045161)4.10593191
38potassium ion homeostasis (GO:0055075)4.10230587
39detection of mechanical stimulus involved in sensory perception (GO:0050974)4.09016381
40negative regulation of homotypic cell-cell adhesion (GO:0034111)4.01543743
41amino acid import (GO:0043090)3.99714071
42cell communication involved in cardiac conduction (GO:0086065)3.92908126
43action potential (GO:0001508)3.92738909
44positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.92657124
45cellular sodium ion homeostasis (GO:0006883)3.91824605
46sympathetic nervous system development (GO:0048485)3.91769990
47cellular response to nicotine (GO:0071316)3.91387483
48regulation of platelet aggregation (GO:0090330)3.88274133
49neurotransmitter uptake (GO:0001504)3.84357258
50adenosine metabolic process (GO:0046085)3.81512631
51neuronal action potential propagation (GO:0019227)3.80022835
52cerebellar granule cell differentiation (GO:0021707)3.77913806
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.74585227
54neuromuscular synaptic transmission (GO:0007274)3.73363323
55exploration behavior (GO:0035640)3.72569370
56behavioral response to nicotine (GO:0035095)3.72515992
57neurotransmitter-gated ion channel clustering (GO:0072578)3.70992758
58positive regulation of potassium ion transmembrane transport (GO:1901381)3.69665509
59astrocyte development (GO:0014002)3.68005120
60ionotropic glutamate receptor signaling pathway (GO:0035235)3.65879329
61positive regulation of synapse maturation (GO:0090129)3.63495516
62axon cargo transport (GO:0008088)3.62006471
63calcium-mediated signaling using intracellular calcium source (GO:0035584)3.60342125
64positive regulation of synaptic transmission, GABAergic (GO:0032230)3.59436161
65potassium ion export (GO:0071435)3.59003589
66establishment of mitochondrion localization (GO:0051654)3.57609976
67retinal ganglion cell axon guidance (GO:0031290)3.56247829
68neurotransmitter secretion (GO:0007269)3.49625916
69regulation of neuronal synaptic plasticity (GO:0048168)3.48864893
70positive regulation of cardiac muscle hypertrophy (GO:0010613)3.46334189
71positive regulation of muscle hypertrophy (GO:0014742)3.46334189
72negative regulation of complement activation (GO:0045916)3.42140012
73dopamine biosynthetic process (GO:0042416)3.38479349
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29624421
75peristalsis (GO:0030432)3.28125479
76positive regulation of neurological system process (GO:0031646)3.26225382
77myelination (GO:0042552)3.25919846
78intermediate filament organization (GO:0045109)3.25883651
79regulation of neurotransmitter levels (GO:0001505)3.23442315
80ensheathment of neurons (GO:0007272)3.21963133
81axon ensheathment (GO:0008366)3.21963133
82regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21540650
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20267369
84mitochondrion transport along microtubule (GO:0047497)3.20267369
85vocalization behavior (GO:0071625)3.19263524
86neurotransmitter transport (GO:0006836)3.17479660
87cell communication by electrical coupling (GO:0010644)3.16497666
88multicellular organismal response to stress (GO:0033555)3.13481745
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12638277
90regulation of synaptic vesicle exocytosis (GO:2000300)3.12407893
91long-term synaptic potentiation (GO:0060291)3.11926993
92phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.11605909
93acrosome reaction (GO:0007340)3.11577488
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.10921615
95synaptic vesicle endocytosis (GO:0048488)3.10382331
96synaptic transmission, glutamatergic (GO:0035249)3.09040310
97intermediate filament-based process (GO:0045103)3.08287108
98negative regulation of neurotransmitter transport (GO:0051589)3.07320118
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07319399
100regulation of cell communication by electrical coupling (GO:0010649)3.06779395
101glutamate secretion (GO:0014047)3.06675464
102behavioral response to ethanol (GO:0048149)3.06522354
103membrane repolarization (GO:0086009)3.05184579
104gamma-aminobutyric acid signaling pathway (GO:0007214)3.04596934
105regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.04235768
106regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.03991631
107neuron cell-cell adhesion (GO:0007158)3.03191520
108intermediate filament cytoskeleton organization (GO:0045104)3.03029151
109regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.02604314
110glutamate receptor signaling pathway (GO:0007215)3.01393166
111gamma-aminobutyric acid transport (GO:0015812)3.01015314
112regulation of synapse maturation (GO:0090128)3.00070561
113adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.99617263
114axon development (GO:0061564)2.98942545
115auditory behavior (GO:0031223)2.97486540
116positive regulation of potassium ion transport (GO:0043268)2.97229088
117innervation (GO:0060384)2.96346052
118sodium ion transmembrane transport (GO:0035725)2.96327240
119acidic amino acid transport (GO:0015800)2.96252166
120negative regulation of inclusion body assembly (GO:0090084)2.95521106
121response to methylmercury (GO:0051597)2.94444347
122regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.93525429
123regulation of neurotransmitter uptake (GO:0051580)2.93392118
124synaptic vesicle maturation (GO:0016188)2.93333723
125myelin maintenance (GO:0043217)2.92942072
126negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92740623
127regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.91372332
128regulation of amyloid precursor protein catabolic process (GO:1902991)2.90829295
129long-chain fatty acid biosynthetic process (GO:0042759)2.90474810
130neuromuscular process controlling balance (GO:0050885)2.89601780
131activation of protein kinase A activity (GO:0034199)2.89217601
132regulation of neurotransmitter transport (GO:0051588)2.88160710
133endothelial cell chemotaxis (GO:0035767)2.88153669
134plasma membrane repair (GO:0001778)2.87564230
135nerve growth factor signaling pathway (GO:0038180)2.86967703
136response to ATP (GO:0033198)2.86853358
137negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.86747976
138sensory perception of pain (GO:0019233)2.86652241
139cranial nerve development (GO:0021545)2.86020732
140response to acidic pH (GO:0010447)2.84573766
141phenol-containing compound catabolic process (GO:0019336)2.84343328
142calcium ion-dependent exocytosis (GO:0017156)2.84248530
143regulation of ARF protein signal transduction (GO:0032012)2.82521169
144regulation of long-term neuronal synaptic plasticity (GO:0048169)2.81626534
145membrane budding (GO:0006900)2.80180524
146organelle transport along microtubule (GO:0072384)2.79870858
147alanine transport (GO:0032328)2.79819117
148neuron fate specification (GO:0048665)2.79480303
149neurotransmitter catabolic process (GO:0042135)2.78976003
150regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78964482
151negative regulation of cation channel activity (GO:2001258)2.78232463
152neuron-neuron synaptic transmission (GO:0007270)2.78051448
153layer formation in cerebral cortex (GO:0021819)2.77816313
154regulation of respiratory system process (GO:0044065)2.76646037
155synaptic vesicle exocytosis (GO:0016079)2.76445181
156negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.76358365
157adult walking behavior (GO:0007628)2.76312764
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76035927
159regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75267230
160regulation of sensory perception (GO:0051931)2.74827561
161regulation of sensory perception of pain (GO:0051930)2.74827561
162regulation of synapse structural plasticity (GO:0051823)2.74220114
163regulation of neurotransmitter secretion (GO:0046928)2.73393223
164startle response (GO:0001964)2.73346435
165transmission of nerve impulse (GO:0019226)2.73133239
166axonal fasciculation (GO:0007413)2.72571852
167myelination in peripheral nervous system (GO:0022011)2.72406822
168peripheral nervous system axon ensheathment (GO:0032292)2.72406822
169regulation of potassium ion transmembrane transporter activity (GO:1901016)2.72210001
170L-glutamate transport (GO:0015813)2.71172797
171cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.70943133
172regulation of axon regeneration (GO:0048679)2.70036327
173regulation of neuron projection regeneration (GO:0070570)2.70036327
174positive regulation of membrane potential (GO:0045838)2.69043444
175membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.68882480
176protein localization to synapse (GO:0035418)2.68617719
177regulation of synaptic transmission, glutamatergic (GO:0051966)2.67671619
178neuron projection regeneration (GO:0031102)2.67020314
179cerebellar Purkinje cell differentiation (GO:0021702)2.66852347
180vesicle transport along microtubule (GO:0047496)2.65391136
181regulation of synaptic vesicle transport (GO:1902803)2.65137800
182negative regulation of protein activation cascade (GO:2000258)2.64945122
183regulation of potassium ion transmembrane transport (GO:1901379)2.64531093
184regulation of cell maturation (GO:1903429)2.64500035

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.85909102
2GBX2_23144817_ChIP-Seq_PC3_Human3.07659683
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03840373
4JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79366386
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76677258
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71897116
7TAF15_26573619_Chip-Seq_HEK293_Human2.71484102
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.55430547
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52625439
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52625439
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.49474326
12VDR_22108803_ChIP-Seq_LS180_Human2.49200702
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41755727
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41194441
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36898222
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.35124083
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.33885836
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.30714278
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25143240
20REST_21632747_ChIP-Seq_MESCs_Mouse2.21601729
21NR3C1_23031785_ChIP-Seq_PC12_Mouse2.10602622
22SMAD4_21799915_ChIP-Seq_A2780_Human1.92773527
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.89316851
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.85881972
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.82836377
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78686016
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.78595014
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78354481
29IGF1R_20145208_ChIP-Seq_DFB_Human1.77264318
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.73954023
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66896466
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.60536193
33P300_19829295_ChIP-Seq_ESCs_Human1.60433694
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.59957968
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59832810
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57238235
37AR_21572438_ChIP-Seq_LNCaP_Human1.57130120
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.56497308
39* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56204067
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51671701
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51066677
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46528723
43AHR_22903824_ChIP-Seq_MCF-7_Human1.46430459
44WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46253046
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40730430
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.39826798
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38447805
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37980298
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37216353
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37195272
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.36536821
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35986952
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35898002
54ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35691703
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.34053501
56MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33274418
57AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32077398
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31244440
59RNF2_27304074_Chip-Seq_NSC_Mouse1.28238928
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.28040611
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24786115
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24717140
63STAT3_23295773_ChIP-Seq_U87_Human1.22318496
64BCAT_22108803_ChIP-Seq_LS180_Human1.22289078
65DROSHA_22980978_ChIP-Seq_HELA_Human1.21876317
66AR_25329375_ChIP-Seq_VCAP_Human1.21724106
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21570786
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.20478989
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18043444
70PRDM14_20953172_ChIP-Seq_ESCs_Human1.17376827
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17276007
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.16968669
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16027742
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14765068
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14027336
76* SMAD3_21741376_ChIP-Seq_HESCs_Human1.13203363
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13153060
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11783912
79ZNF263_19887448_ChIP-Seq_K562_Human1.11119892
80* CTCF_27219007_Chip-Seq_Bcells_Human1.11063002
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10802077
82* SMAD4_21741376_ChIP-Seq_HESCs_Human1.10405844
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09730356
84ZNF274_21170338_ChIP-Seq_K562_Hela1.09452586
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08231711
86TP53_16413492_ChIP-PET_HCT116_Human1.06937556
87KDM2B_26808549_Chip-Seq_REH_Human1.06764656
88JUN_21703547_ChIP-Seq_K562_Human1.06704765
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05335587
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03775553
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.03535538
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.03442045
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.03400352
94EGR1_19032775_ChIP-ChIP_M12_Human1.03070671
95SOX2_19829295_ChIP-Seq_ESCs_Human1.03052734
96NANOG_19829295_ChIP-Seq_ESCs_Human1.03052734
97RARB_27405468_Chip-Seq_BRAIN_Mouse1.02498063
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01636353
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.01500092
100* SMAD3_21741376_ChIP-Seq_EPCs_Human0.99533066
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99311036
102P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98357635
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97065314
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97065314
105KDM2B_26808549_Chip-Seq_K562_Human0.96026755
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95908841
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95765755
108RUNX2_22187159_ChIP-Seq_PCA_Human0.95362654
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94930142
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94851705
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94837336
112TCF4_23295773_ChIP-Seq_U87_Human0.94183696
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94172293
114* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93859895
115CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93115145
116* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92940016
117POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92928217
118KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.91418140
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91233756
120AR_19668381_ChIP-Seq_PC3_Human0.90686066
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90117662
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.89583082
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.87913298
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87794324
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87738212
126* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87305477
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87121432
128DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86154934
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85443499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception7.06786222
2MP0002736_abnormal_nociception_after6.54773374
3* MP0002735_abnormal_chemical_nociception6.48834842
4MP0001986_abnormal_taste_sensitivity4.75466690
5MP0004270_analgesia4.64017720
6MP0004858_abnormal_nervous_system4.38891178
7MP0002734_abnormal_mechanical_nocicepti4.22589874
8* MP0002733_abnormal_thermal_nociception4.05040366
9MP0003690_abnormal_glial_cell3.85251516
10* MP0001970_abnormal_pain_threshold3.55676543
11* MP0006276_abnormal_autonomic_nervous3.37127017
12MP0004885_abnormal_endolymph2.78238352
13MP0002751_abnormal_autonomic_nervous2.50610368
14MP0002272_abnormal_nervous_system2.35220431
15MP0000372_irregular_coat_pigmentation2.19848090
16MP0002184_abnormal_innervation2.16391914
17MP0002067_abnormal_sensory_capabilities2.15703912
18MP0005167_abnormal_blood-brain_barrier2.14476020
19MP0004859_abnormal_synaptic_plasticity2.00989510
20MP0000569_abnormal_digit_pigmentation1.95519129
21MP0002822_catalepsy1.90441290
22MP0010386_abnormal_urinary_bladder1.87853142
23MP0009780_abnormal_chondrocyte_physiolo1.83550230
24MP0003283_abnormal_digestive_organ1.71535716
25MP0001502_abnormal_circadian_rhythm1.71180634
26MP0003635_abnormal_synaptic_transmissio1.71151800
27MP0003880_abnormal_central_pattern1.63061821
28MP0001984_abnormal_olfaction1.57922915
29MP0009745_abnormal_behavioral_response1.56977352
30MP0000566_synostosis1.56448226
31MP0009046_muscle_twitch1.55734483
32MP0002332_abnormal_exercise_endurance1.51296487
33MP0008260_abnormal_autophagy1.44639806
34MP0001958_emphysema1.43755921
35MP0001348_abnormal_lacrimal_gland1.40801480
36MP0000955_abnormal_spinal_cord1.39226499
37MP0001177_atelectasis1.39075602
38MP0001270_distended_abdomen1.35856485
39MP0002064_seizures1.35647367
40MP0002572_abnormal_emotion/affect_behav1.32550624
41MP0002063_abnormal_learning/memory/cond1.31947174
42MP0000538_abnormal_urinary_bladder1.30975920
43* MP0004811_abnormal_neuron_physiology1.29509284
44MP0001440_abnormal_grooming_behavior1.27962890
45MP0003329_amyloid_beta_deposits1.24473028
46MP0003656_abnormal_erythrocyte_physiolo1.22550990
47MP0005423_abnormal_somatic_nervous1.20612217
48MP0002638_abnormal_pupillary_reflex1.17162442
49MP0005551_abnormal_eye_electrophysiolog1.15894508
50MP0004147_increased_porphyrin_level1.13881447
51MP0002653_abnormal_ependyma_morphology1.13044205
52MP0000778_abnormal_nervous_system1.12746904
53MP0001905_abnormal_dopamine_level1.11517877
54MP0002882_abnormal_neuron_morphology1.10779267
55MP0002152_abnormal_brain_morphology1.09359687
56MP0000749_muscle_degeneration1.07890500
57MP0001188_hyperpigmentation1.07392999
58MP0003633_abnormal_nervous_system1.06778223
59MP0002837_dystrophic_cardiac_calcinosis1.04213111
60MP0000751_myopathy1.03727073
61MP0009379_abnormal_foot_pigmentation1.00361903
62MP0000026_abnormal_inner_ear1.00297318
63MP0004924_abnormal_behavior0.94674806
64MP0005386_behavior/neurological_phenoty0.94674806
65MP0002229_neurodegeneration0.93544569
66MP0002752_abnormal_somatic_nervous0.92680043
67MP0004142_abnormal_muscle_tone0.87998599
68MP0001299_abnormal_eye_distance/0.87330753
69MP0003136_yellow_coat_color0.87036759
70MP0001486_abnormal_startle_reflex0.86345181
71MP0003634_abnormal_glial_cell0.85814552
72MP0002066_abnormal_motor_capabilities/c0.85693426
73MP0008569_lethality_at_weaning0.85433258
74MP0005083_abnormal_biliary_tract0.84853899
75MP0002557_abnormal_social/conspecific_i0.84658622
76MP0003631_nervous_system_phenotype0.83898976
77MP0004145_abnormal_muscle_electrophysio0.80293200
78MP0002089_abnormal_postnatal_growth/wei0.79616318
79MP0008874_decreased_physiological_sensi0.79172052
80MP0000747_muscle_weakness0.76097142
81MP0000920_abnormal_myelination0.76072087
82MP0003950_abnormal_plasma_membrane0.73933387
83MP0005253_abnormal_eye_physiology0.73580897
84MP0005171_absent_coat_pigmentation0.73575308
85MP0000534_abnormal_ureter_morphology0.73220197
86MP0002909_abnormal_adrenal_gland0.73052467
87MP0005670_abnormal_white_adipose0.71281856
88MP0004085_abnormal_heartbeat0.70846632
89MP0010771_integument_phenotype0.70335169
90MP0003878_abnormal_ear_physiology0.70130873
91MP0005377_hearing/vestibular/ear_phenot0.70130873
92MP0000631_abnormal_neuroendocrine_gland0.69539866
93MP0001501_abnormal_sleep_pattern0.66937331
94MP0005595_abnormal_vascular_smooth0.66667188
95MP0003183_abnormal_peptide_metabolism0.66085543
96MP0004036_abnormal_muscle_relaxation0.65598047
97MP0000462_abnormal_digestive_system0.65269094
98MP0004742_abnormal_vestibular_system0.64235746
99MP0000579_abnormal_nail_morphology0.63335858
100MP0003045_fibrosis0.63275395
101MP0008872_abnormal_physiological_respon0.63042155
102MP0002133_abnormal_respiratory_system0.62150778
103MP0005388_respiratory_system_phenotype0.62150778
104MP0002972_abnormal_cardiac_muscle0.62089244
105MP0009697_abnormal_copulation0.61993140
106MP0001963_abnormal_hearing_physiology0.61811653
107MP0008775_abnormal_heart_ventricle0.60501127
108MP0003861_abnormal_nervous_system0.60377446
109MP0003075_altered_response_to0.60347868
110MP0004133_heterotaxia0.59962555
111MP0001664_abnormal_digestion0.59890454
112MP0003122_maternal_imprinting0.59722855
113MP0002069_abnormal_eating/drinking_beha0.59558231
114MP0000604_amyloidosis0.58432334
115MP0004130_abnormal_muscle_cell0.57850330
116MP0003866_abnormal_defecation0.57556435
117MP0010769_abnormal_survival0.55891023
118MP0005645_abnormal_hypothalamus_physiol0.55489892
119MP0004215_abnormal_myocardial_fiber0.52476186
120MP0005535_abnormal_body_temperature0.52419005
121MP0002160_abnormal_reproductive_system0.51928819
122MP0004883_abnormal_blood_vessel0.50863042
123MP0001529_abnormal_vocalization0.50166791
124MP0000427_abnormal_hair_cycle0.48471246
125MP0001485_abnormal_pinna_reflex0.45889512
126MP0000015_abnormal_ear_pigmentation0.44113991
127MP0005646_abnormal_pituitary_gland0.44100400
128MP0001542_abnormal_bone_strength0.43666871
129MP0003879_abnormal_hair_cell0.43350266
130MP0002163_abnormal_gland_morphology0.43111940
131MP0005409_darkened_coat_color0.42652157
132MP0004484_altered_response_of0.41997617
133MP0000759_abnormal_skeletal_muscle0.39647307
134MP0003137_abnormal_impulse_conducting0.38808201
135MP0003632_abnormal_nervous_system0.38202411
136MP0002876_abnormal_thyroid_physiology0.38002815

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.12605738
2Hypothermia (HP:0002045)6.30980160
3Myokymia (HP:0002411)6.15919983
4Segmental peripheral demyelination/remyelination (HP:0003481)5.82844640
5Dysautonomia (HP:0002459)5.67050890
6Action tremor (HP:0002345)5.53597106
7Termporal pattern (HP:0011008)5.41155276
8Insidious onset (HP:0003587)5.41155276
9Impaired pain sensation (HP:0007328)5.14889047
10Abnormality of pain sensation (HP:0010832)5.14889047
11Pheochromocytoma (HP:0002666)4.80568153
12Abnormal autonomic nervous system physiology (HP:0012332)4.62565936
13Neuroendocrine neoplasm (HP:0100634)4.46631025
14Abnormality of binocular vision (HP:0011514)4.44950510
15Diplopia (HP:0000651)4.44950510
16Decreased number of peripheral myelinated nerve fibers (HP:0003380)4.40940367
17Steppage gait (HP:0003376)4.35616627
18Foot dorsiflexor weakness (HP:0009027)4.19924196
19Hammertoe (HP:0001765)3.96242323
20Autoamputation (HP:0001218)3.96232759
21Neurofibrillary tangles (HP:0002185)3.91805313
22Abnormality of the foot musculature (HP:0001436)3.75611408
23Genetic anticipation (HP:0003743)3.57889482
24Atonic seizures (HP:0010819)3.52473192
25Onion bulb formation (HP:0003383)3.47514934
26Scanning speech (HP:0002168)3.45142120
27Neoplasm of the heart (HP:0100544)3.44845826
28Febrile seizures (HP:0002373)3.43628506
29Focal seizures (HP:0007359)3.40905759
30Postural instability (HP:0002172)3.38598633
31Megalencephaly (HP:0001355)3.37798086
32Myotonia (HP:0002486)3.34672340
33Orthostatic hypotension (HP:0001278)3.30625216
34Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.24903333
35Ankle clonus (HP:0011448)3.24004040
36Failure to thrive in infancy (HP:0001531)3.21002870
37Supranuclear gaze palsy (HP:0000605)3.18370806
38Thyroid carcinoma (HP:0002890)3.18361119
39Abnormal eating behavior (HP:0100738)3.10726120
40Focal motor seizures (HP:0011153)3.09264370
41Arthropathy (HP:0003040)3.04625715
42Distal sensory impairment (HP:0002936)3.02054053
43Bradycardia (HP:0001662)2.98976225
44Aplasia involving bones of the extremities (HP:0009825)2.96358522
45Aplasia involving bones of the upper limbs (HP:0009823)2.96358522
46Aplasia of the phalanges of the hand (HP:0009802)2.96358522
47Alacrima (HP:0000522)2.95793785
48Hyporeflexia of lower limbs (HP:0002600)2.94435672
49Abnormality of the corticospinal tract (HP:0002492)2.93034612
50Cerebral inclusion bodies (HP:0100314)2.92328254
51Decreased motor nerve conduction velocity (HP:0003431)2.86431663
52Abnormality of the vocal cords (HP:0008777)2.83231461
53Progressive cerebellar ataxia (HP:0002073)2.79184707
54Impaired proprioception (HP:0010831)2.78073915
55Hemiplegia (HP:0002301)2.77601512
56Akinesia (HP:0002304)2.75203988
57Hypoventilation (HP:0002791)2.70533701
58Hypoplasia of the brainstem (HP:0002365)2.69883498
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.69883498
60Dysdiadochokinesis (HP:0002075)2.67177850
61Distal arthrogryposis (HP:0005684)2.66537383
62Submucous cleft hard palate (HP:0000176)2.62096270
63Bundle branch block (HP:0011710)2.60665397
64Turricephaly (HP:0000262)2.59385064
65Bronchomalacia (HP:0002780)2.58767416
66Limb dystonia (HP:0002451)2.57388652
67Hemiparesis (HP:0001269)2.56238716
68Hypercortisolism (HP:0001578)2.54221371
69Recurrent corneal erosions (HP:0000495)2.53695889
70Neoplasm of the peripheral nervous system (HP:0100007)2.50389050
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.49565804
72Polyphagia (HP:0002591)2.49462088
73Increased IgE level (HP:0003212)2.47948758
74Areflexia of lower limbs (HP:0002522)2.44094156
75Urinary urgency (HP:0000012)2.43455079
76Peripheral hypomyelination (HP:0007182)2.41936512
77Hand muscle atrophy (HP:0009130)2.38941078
78Morphological abnormality of the pyramidal tract (HP:0002062)2.38543413
79Amblyopia (HP:0000646)2.37960270
80Neuronal loss in central nervous system (HP:0002529)2.34585830
81Dysmetria (HP:0001310)2.30605620
82Rigidity (HP:0002063)2.30354208
83Postural tremor (HP:0002174)2.25930647
84Increased circulating renin level (HP:0000848)2.25530559
85Spastic gait (HP:0002064)2.25332828
86Abnormality of the diencephalon (HP:0010662)2.24092415
87Abnormality of the lower motor neuron (HP:0002366)2.23383686
88Obstructive sleep apnea (HP:0002870)2.23263607
89Bradykinesia (HP:0002067)2.22194063
90Facial shape deformation (HP:0011334)2.22025766
91Potter facies (HP:0002009)2.22025766
92Decreased lacrimation (HP:0000633)2.22021102
93Absence seizures (HP:0002121)2.21574671
94Retinal dysplasia (HP:0007973)2.20698407
95Intention tremor (HP:0002080)2.18945201
96Dialeptic seizures (HP:0011146)2.18705292
97Impaired vibration sensation in the lower limbs (HP:0002166)2.17179326
98Ventricular fibrillation (HP:0001663)2.16826312
99Distal upper limb amyotrophy (HP:0007149)2.13664916
100Upper limb amyotrophy (HP:0009129)2.13664916
101Generalized tonic-clonic seizures (HP:0002069)2.13663045
102Anosmia (HP:0000458)2.13305388
103Gait imbalance (HP:0002141)2.12694525
104Hyperventilation (HP:0002883)2.11495549
105Dysmetric saccades (HP:0000641)2.10387781
106Abnormality of magnesium homeostasis (HP:0004921)2.08605035
107Gaze-evoked nystagmus (HP:0000640)2.07706099
108Exotropia (HP:0000577)2.06066986
109Lower limb muscle weakness (HP:0007340)2.05782024
110Abnormality of dental color (HP:0011073)2.05453883
111Distal lower limb muscle weakness (HP:0009053)2.04311444
112Torticollis (HP:0000473)2.04256986
113Palpitations (HP:0001962)2.03353979
114Urinary bladder sphincter dysfunction (HP:0002839)2.02355063
115Mutism (HP:0002300)2.02094892
116Abnormality of the parietal bone (HP:0002696)2.02042918
117Cerebral hemorrhage (HP:0001342)2.01363897
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99170807
119Short 4th metacarpal (HP:0010044)1.99170807
120Episodic fever (HP:0001954)1.99086582
121Visual hallucinations (HP:0002367)1.98820123
122Peripheral demyelination (HP:0011096)1.97250873
123Hypomagnesemia (HP:0002917)1.96779618
124Upper limb muscle weakness (HP:0003484)1.96748609
125Epileptiform EEG discharges (HP:0011182)1.95690643
126Abnormal hair whorl (HP:0010721)1.95655430
127Chin dimple (HP:0010751)1.92064426
128Fetal akinesia sequence (HP:0001989)1.90677421
129Paraplegia (HP:0010550)1.90480335
130Insomnia (HP:0100785)1.88717054
131Epileptic encephalopathy (HP:0200134)1.86370733
132Hypoplasia of the iris (HP:0007676)1.85765602
133Truncal ataxia (HP:0002078)1.85573171
134Anhidrosis (HP:0000970)1.85008489
135Stereotypic behavior (HP:0000733)1.81756978
136Increased CSF protein (HP:0002922)1.79574391
137EEG with generalized epileptiform discharges (HP:0011198)1.79314647
138Tetraplegia (HP:0002445)1.78633683
139Axonal loss (HP:0003447)1.78366502
140Mask-like facies (HP:0000298)1.78276423
141Genital tract atresia (HP:0001827)1.77685646
142Menstrual irregularities (HP:0000858)1.77129772
143Trigonocephaly (HP:0000243)1.76759258
144Abnormality of saccadic eye movements (HP:0000570)1.76535127
145Sensory axonal neuropathy (HP:0003390)1.75694053
146Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74112418
147Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73609516
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.73609516
149Neuroblastoma (HP:0003006)1.73134527
150Primitive neuroectodermal tumor (HP:0030065)1.73134527
151Neuroblastic tumors (HP:0004376)1.73134527
152Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.73134527
153Cutaneous finger syndactyly (HP:0010554)1.71856926
154Spastic paraplegia (HP:0001258)1.71748883
155Abnormality of the 4th metacarpal (HP:0010012)1.71655969
156Rapidly progressive (HP:0003678)1.71336088
157Impaired vibratory sensation (HP:0002495)1.71208752
158Neoplasm of the thyroid gland (HP:0100031)1.69466439
159Prolonged QT interval (HP:0001657)1.67937498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK15.58288364
2NTRK33.73550417
3LMTK23.62300247
4MATK3.32646335
5KSR23.19331218
6NTRK23.17304565
7MINK13.07293135
8MAP4K23.06424631
9MAP3K22.92390032
10LIMK12.80190895
11MAP3K92.64788949
12GRK52.61282213
13RIPK42.59493347
14CASK2.27220613
15MAP3K122.17949266
16RIPK12.16579744
17EPHA42.02682464
18PHKG22.02071890
19PHKG12.02071890
20PNCK1.95647721
21RET1.94929153
22FGFR21.94704638
23ARAF1.88014627
24LATS21.85802704
25TYRO31.81289031
26CAMK2B1.78169425
27PKN11.78114885
28EPHA31.72341525
29MAP3K41.57280258
30MAPK151.54753267
31MAP2K71.53317509
32MARK31.49590458
33MAP2K41.42836725
34MAP2K11.41988837
35MAPK131.39147126
36MAPKAPK31.37258537
37MARK21.35817504
38GRK71.32883926
39STK391.31052934
40SGK2231.28757994
41SGK4941.28757994
42WNK11.28735772
43TNIK1.26114139
44TRIB31.24562997
45RPS6KA21.24307310
46SIK31.24029465
47PAK61.23642584
48ADRBK21.20938985
49SIK21.15166259
50FER1.11761195
51MAP3K11.10064943
52ADRBK11.08462195
53MAP2K21.06088704
54DDR21.05550644
55WNK40.99245802
56DAPK20.95596344
57PDK20.95309155
58PDGFRA0.94905026
59PRKCE0.93348758
60SGK10.93273221
61SGK20.93263338
62YES10.86900015
63CDK50.83785319
64PINK10.82512894
65CAMKK20.81959164
66NEK60.81589251
67PRKCG0.74791564
68UHMK10.74466750
69MARK10.73373363
70DYRK1A0.73359850
71PRKG20.72466121
72ICK0.69823928
73PRKD10.69117120
74DYRK20.68313126
75MAPK120.67963554
76BLK0.67888831
77BMPR1B0.65981827
78PKN20.63689493
79FES0.63158893
80CSNK1G10.62946094
81RPS6KA30.60716771
82CSNK1G20.60145967
83CDK140.59720156
84CAMK2A0.57680363
85CAMK10.57378261
86PDGFRB0.53329536
87EPHB10.51469803
88SGK30.51034683
89OXSR10.50530223
90MAP3K70.50311212
91PRKG10.49591258
92MET0.47563242
93CSNK1G30.47434947
94BRAF0.47034464
95SCYL20.46118610
96IRAK10.45961411
97FYN0.45938492
98CDK150.45153468
99CSNK1A10.44667791
100ERBB20.44443536
101TRPM70.43990502
102CAMK2G0.43863949
103CAMK2D0.43186053
104STK240.42140268
105PRKACA0.41900458
106IRAK20.40695331
107CDC42BPA0.39765741
108PRKAA10.39686057
109ROCK20.39195745
110STK380.38694529
111MUSK0.38186320
112PTK20.37974316
113CDK11A0.37726515
114CAMKK10.37392671
115ACVR1B0.37264396
116PRKCZ0.37047509
117PDK10.36822599
118PAK30.36735001
119PIM20.36114306
120ALK0.35447710
121PDPK10.35206868
122STK110.34713726
123PTK2B0.34136621
124MAP2K60.34034481
125ROCK10.33836107
126BMX0.33013152
127MAPK40.32890068
128MAPK70.32100125
129GSK3B0.31980653
130FGFR30.31523300
131CSNK1D0.31153973
132CSNK1A1L0.29451172
133MAPKAPK50.27625902
134BCR0.27504646
135PLK20.27239891
136SRC0.26339281
137PRKACB0.25701345
138CDK180.24471229
139CSNK1E0.24323545
140PRKD30.23404736
141MYLK0.22912307
142PRKACG0.22697395
143MAPK100.22402337
144TNK20.21199616
145TESK10.20758141
146PRKCA0.19996035
147PRKCH0.19770585

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.26832921
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.19189951
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.08405564
4Olfactory transduction_Homo sapiens_hsa047402.50323804
5Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.20115735
6Taste transduction_Homo sapiens_hsa047422.11160086
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.07644870
8Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.95853728
9Insulin secretion_Homo sapiens_hsa049111.94371499
10Thyroid cancer_Homo sapiens_hsa052161.90200950
11Dopaminergic synapse_Homo sapiens_hsa047281.87620608
12Cholinergic synapse_Homo sapiens_hsa047251.84719250
13Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81413552
14Collecting duct acid secretion_Homo sapiens_hsa049661.80805828
15Dorso-ventral axis formation_Homo sapiens_hsa043201.65381657
16Serotonergic synapse_Homo sapiens_hsa047261.64357064
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62724786
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58643824
19Circadian entrainment_Homo sapiens_hsa047131.56096244
20Histidine metabolism_Homo sapiens_hsa003401.55026705
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47203076
22Long-term potentiation_Homo sapiens_hsa047201.47062558
23Oxidative phosphorylation_Homo sapiens_hsa001901.46559325
24Salivary secretion_Homo sapiens_hsa049701.45515219
25Glutamatergic synapse_Homo sapiens_hsa047241.43971499
26Cardiac muscle contraction_Homo sapiens_hsa042601.43951476
27Parkinsons disease_Homo sapiens_hsa050121.32397450
28GnRH signaling pathway_Homo sapiens_hsa049121.32260059
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31763939
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.27636176
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.23909979
32Long-term depression_Homo sapiens_hsa047301.22664602
33Vibrio cholerae infection_Homo sapiens_hsa051101.20790466
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20759103
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.16661208
36Gap junction_Homo sapiens_hsa045401.16598939
37Arginine and proline metabolism_Homo sapiens_hsa003301.15143883
38Gastric acid secretion_Homo sapiens_hsa049711.14847661
39Nicotine addiction_Homo sapiens_hsa050331.14690573
40Alzheimers disease_Homo sapiens_hsa050101.14368881
41Inositol phosphate metabolism_Homo sapiens_hsa005621.13693211
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12725947
43Morphine addiction_Homo sapiens_hsa050321.10014035
44Steroid biosynthesis_Homo sapiens_hsa001001.09814846
45Melanoma_Homo sapiens_hsa052181.08575147
46Calcium signaling pathway_Homo sapiens_hsa040201.08391449
47Glioma_Homo sapiens_hsa052141.05831722
48Regulation of autophagy_Homo sapiens_hsa041401.04824894
49Amphetamine addiction_Homo sapiens_hsa050311.01712991
50Phagosome_Homo sapiens_hsa041451.00304217
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98131111
52Renin secretion_Homo sapiens_hsa049240.98012591
53Estrogen signaling pathway_Homo sapiens_hsa049150.97290149
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.96771390
55Salmonella infection_Homo sapiens_hsa051320.95854116
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.95619293
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.94414082
58GABAergic synapse_Homo sapiens_hsa047270.94307092
59beta-Alanine metabolism_Homo sapiens_hsa004100.93972299
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.93668202
61Axon guidance_Homo sapiens_hsa043600.92325200
62Melanogenesis_Homo sapiens_hsa049160.91248674
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90005297
64Insulin signaling pathway_Homo sapiens_hsa049100.89138696
65ErbB signaling pathway_Homo sapiens_hsa040120.88820275
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88350234
67Oxytocin signaling pathway_Homo sapiens_hsa049210.86416506
68Pancreatic secretion_Homo sapiens_hsa049720.85809998
69VEGF signaling pathway_Homo sapiens_hsa043700.83625784
70Vitamin B6 metabolism_Homo sapiens_hsa007500.82927769
71Arginine biosynthesis_Homo sapiens_hsa002200.82352995
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80960655
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80678968
74Type II diabetes mellitus_Homo sapiens_hsa049300.80298889
75Prolactin signaling pathway_Homo sapiens_hsa049170.75837209
76Endometrial cancer_Homo sapiens_hsa052130.74672913
77Circadian rhythm_Homo sapiens_hsa047100.73579582
78Huntingtons disease_Homo sapiens_hsa050160.73508654
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71557215
80Renin-angiotensin system_Homo sapiens_hsa046140.71349076
81Oocyte meiosis_Homo sapiens_hsa041140.71090332
82Choline metabolism in cancer_Homo sapiens_hsa052310.70463758
83ABC transporters_Homo sapiens_hsa020100.69840462
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69448239
85Tight junction_Homo sapiens_hsa045300.69427113
86Mineral absorption_Homo sapiens_hsa049780.69286765
87Thyroid hormone synthesis_Homo sapiens_hsa049180.68085943
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67386583
89Ovarian steroidogenesis_Homo sapiens_hsa049130.67233426
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66649612
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63463484
92Rap1 signaling pathway_Homo sapiens_hsa040150.62505097
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62134559
94Hippo signaling pathway_Homo sapiens_hsa043900.61820465
95cAMP signaling pathway_Homo sapiens_hsa040240.61007468
96Nitrogen metabolism_Homo sapiens_hsa009100.60314265
97Endocytosis_Homo sapiens_hsa041440.60157968
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59877503
99Ras signaling pathway_Homo sapiens_hsa040140.59567982
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58908320
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.57577361
102Ether lipid metabolism_Homo sapiens_hsa005650.56987184
103Phototransduction_Homo sapiens_hsa047440.56311096
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54808055
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54451740
106Phenylalanine metabolism_Homo sapiens_hsa003600.53437935
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53111469
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52703303
109MAPK signaling pathway_Homo sapiens_hsa040100.52639465
110Dilated cardiomyopathy_Homo sapiens_hsa054140.52382501
111Cocaine addiction_Homo sapiens_hsa050300.52266830
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52151662
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51340880
114Rheumatoid arthritis_Homo sapiens_hsa053230.49908986
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48108842
116Glycerolipid metabolism_Homo sapiens_hsa005610.46416186
117Fatty acid elongation_Homo sapiens_hsa000620.44964806
118Bile secretion_Homo sapiens_hsa049760.44813127
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44723140
120African trypanosomiasis_Homo sapiens_hsa051430.43868732
121Prion diseases_Homo sapiens_hsa050200.42415355
122PPAR signaling pathway_Homo sapiens_hsa033200.42147499
123Tyrosine metabolism_Homo sapiens_hsa003500.42068137
124mTOR signaling pathway_Homo sapiens_hsa041500.41771918
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41410136
126AMPK signaling pathway_Homo sapiens_hsa041520.40722721
127Glucagon signaling pathway_Homo sapiens_hsa049220.39628874
128ECM-receptor interaction_Homo sapiens_hsa045120.33490713
129Sphingolipid metabolism_Homo sapiens_hsa006000.33006727
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31696102
131Hedgehog signaling pathway_Homo sapiens_hsa043400.31526664
132Lysine degradation_Homo sapiens_hsa003100.31320714
133Adherens junction_Homo sapiens_hsa045200.30465950
134Basal cell carcinoma_Homo sapiens_hsa052170.30105579

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