PITHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.08027009
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.05898908
3synaptic vesicle maturation (GO:0016188)4.98064000
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46046609
5neuronal action potential propagation (GO:0019227)4.28345976
6neuromuscular process controlling posture (GO:0050884)4.26481378
7regulation of synaptic vesicle exocytosis (GO:2000300)4.21855448
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13521307
9glutamate secretion (GO:0014047)4.00147110
10regulation of synaptic vesicle transport (GO:1902803)3.89123484
11protein maturation by protein folding (GO:0022417)3.77629907
12DNA damage response, detection of DNA damage (GO:0042769)3.75212466
13ATP synthesis coupled proton transport (GO:0015986)3.70870857
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.70870857
15startle response (GO:0001964)3.69771680
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.65964869
17neurotransmitter secretion (GO:0007269)3.55416627
18negative regulation of microtubule polymerization (GO:0031115)3.47207277
19chaperone-mediated protein transport (GO:0072321)3.42631329
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.42207520
21axon ensheathment in central nervous system (GO:0032291)3.33135562
22central nervous system myelination (GO:0022010)3.33135562
23cellular potassium ion homeostasis (GO:0030007)3.32088923
24mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.26357681
25gamma-aminobutyric acid signaling pathway (GO:0007214)3.21685346
26protein localization to synapse (GO:0035418)3.21294322
27establishment of mitochondrion localization (GO:0051654)3.20667130
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20510671
29serotonin metabolic process (GO:0042428)3.19657553
30neurotransmitter transport (GO:0006836)3.19639008
31cerebellar Purkinje cell layer development (GO:0021680)3.17938375
32postsynaptic membrane organization (GO:0001941)3.16825538
33sodium ion export (GO:0071436)3.14328396
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14236669
35pyrimidine nucleobase catabolic process (GO:0006208)3.13390721
36presynaptic membrane assembly (GO:0097105)3.13123013
37microtubule depolymerization (GO:0007019)3.12772470
38negative regulation of inclusion body assembly (GO:0090084)3.11708652
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.10382353
40respiratory electron transport chain (GO:0022904)3.10057917
41protein-cofactor linkage (GO:0018065)3.09838127
42locomotory exploration behavior (GO:0035641)3.07289912
43electron transport chain (GO:0022900)3.05874689
44vocalization behavior (GO:0071625)3.05868763
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05215357
46regulation of neuronal synaptic plasticity (GO:0048168)3.04962820
47male meiosis I (GO:0007141)3.04572736
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03757699
49regulation of vesicle fusion (GO:0031338)3.00476217
50glutamate receptor signaling pathway (GO:0007215)2.97778618
51behavioral response to cocaine (GO:0048148)2.97084846
52synaptic vesicle endocytosis (GO:0048488)2.96378965
53regulation of neurotransmitter levels (GO:0001505)2.95656494
54neuron cell-cell adhesion (GO:0007158)2.94459486
55meiosis I (GO:0007127)2.92504869
56presynaptic membrane organization (GO:0097090)2.92472233
57regulation of synapse structural plasticity (GO:0051823)2.91534897
58neurotransmitter-gated ion channel clustering (GO:0072578)2.91459334
59glycine transport (GO:0015816)2.90181499
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.89860248
61deoxyribose phosphate biosynthetic process (GO:0046385)2.88696662
622-deoxyribonucleotide biosynthetic process (GO:0009265)2.88696662
63transmission of nerve impulse (GO:0019226)2.88110365
64activation of protein kinase A activity (GO:0034199)2.85095399
65calcium ion-dependent exocytosis (GO:0017156)2.84311734
66regulation of long-term neuronal synaptic plasticity (GO:0048169)2.84071355
67spermatid nucleus differentiation (GO:0007289)2.83992465
68cerebellar Purkinje cell differentiation (GO:0021702)2.82357320
69organelle transport along microtubule (GO:0072384)2.82235332
70response to insecticide (GO:0017085)2.81722159
71microtubule polymerization or depolymerization (GO:0031109)2.81655374
72ATP hydrolysis coupled proton transport (GO:0015991)2.80850488
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.80850488
74inner mitochondrial membrane organization (GO:0007007)2.80354372
75mitochondrion transport along microtubule (GO:0047497)2.79695932
76establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.79695932
77righting reflex (GO:0060013)2.79245173
78negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79195795
79response to methylmercury (GO:0051597)2.76816902
80mating behavior (GO:0007617)2.76627729
81protoporphyrinogen IX metabolic process (GO:0046501)2.76387030
82regulation of dopamine metabolic process (GO:0042053)2.75316627
83regulation of catecholamine metabolic process (GO:0042069)2.75316627
84establishment of synaptic vesicle localization (GO:0097480)2.74403171
85synaptic vesicle transport (GO:0048489)2.74403171
86axon cargo transport (GO:0008088)2.71920245
87gamma-aminobutyric acid transport (GO:0015812)2.71199875
88regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70941357
89regulation of glutamate secretion (GO:0014048)2.70401382
90adult walking behavior (GO:0007628)2.68842922
91regulation of calcium ion-dependent exocytosis (GO:0017158)2.67800871
92neurotransmitter uptake (GO:0001504)2.67787447
93regulation of glutamate receptor signaling pathway (GO:1900449)2.67076800
94positive regulation of synapse maturation (GO:0090129)2.66164913
95neuron-neuron synaptic transmission (GO:0007270)2.63534009
96detection of temperature stimulus involved in sensory perception (GO:0050961)2.63270417
97detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63270417
98regulation of protein kinase A signaling (GO:0010738)2.63057244
99exploration behavior (GO:0035640)2.62841843
100regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62625107
101mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61522202
102mitochondrial respiratory chain complex I assembly (GO:0032981)2.61522202
103NADH dehydrogenase complex assembly (GO:0010257)2.61522202
104regulation of autophagic vacuole assembly (GO:2000785)2.61141448
105peptidyl-cysteine modification (GO:0018198)2.61032193
106neurofilament cytoskeleton organization (GO:0060052)2.60255965
107positive regulation of synapse assembly (GO:0051965)2.60056141
108regulation of oxidative phosphorylation (GO:0002082)2.60033264
109regulation of voltage-gated calcium channel activity (GO:1901385)2.59636124
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59581219
111neuron fate determination (GO:0048664)2.59095768
112layer formation in cerebral cortex (GO:0021819)2.58767857
113primary amino compound metabolic process (GO:1901160)2.58730120
114regulation of neurotransmitter secretion (GO:0046928)2.58253765
115regulation of synaptic transmission, dopaminergic (GO:0032225)2.58079327
116amino acid import (GO:0043090)2.57868507
117regulation of neurotransmitter transport (GO:0051588)2.57626813
118establishment of protein localization to mitochondrion (GO:0072655)2.57038974
119positive regulation of neurotransmitter secretion (GO:0001956)2.56654638
120L-amino acid import (GO:0043092)2.56221795
121dendritic spine morphogenesis (GO:0060997)2.55919015
122positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55410338
123calcium-mediated signaling using intracellular calcium source (GO:0035584)2.55094751
124sequestering of actin monomers (GO:0042989)2.55072807
125positive regulation of membrane potential (GO:0045838)2.54617589
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.54587101
127vesicle transport along microtubule (GO:0047496)2.54202017
128protein targeting to mitochondrion (GO:0006626)2.54173113
129regulation of neurotransmitter uptake (GO:0051580)2.53801825
130cerebellar granule cell differentiation (GO:0021707)2.53664533
131response to dietary excess (GO:0002021)2.52444458
132potassium ion homeostasis (GO:0055075)2.51079638
133positive regulation of neurotransmitter transport (GO:0051590)2.50286988
134iron coordination entity transport (GO:1901678)2.50165841
135positive regulation of potassium ion transmembrane transport (GO:1901381)2.49326207
136regulation of postsynaptic membrane potential (GO:0060078)2.48211388
137substantia nigra development (GO:0021762)2.48000275
138establishment of vesicle localization (GO:0051650)2.47678409
139protein insertion into membrane (GO:0051205)2.47542617
140response to pheromone (GO:0019236)2.46604338
141negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.46262101
142protein localization to mitochondrion (GO:0070585)2.46179252
143heme biosynthetic process (GO:0006783)2.46158644
144synaptic transmission, glutamatergic (GO:0035249)2.46054888
145protoporphyrinogen IX biosynthetic process (GO:0006782)2.42950173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.24803536
2REST_21632747_ChIP-Seq_MESCs_Mouse2.82653064
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75535038
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.70584444
5REST_18959480_ChIP-ChIP_MESCs_Mouse2.69134990
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46451018
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.44802323
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.44074184
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35252730
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26285095
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20278122
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19828878
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18419169
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08869059
15E2F7_22180533_ChIP-Seq_HELA_Human2.08755058
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08341172
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.07411565
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06282383
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.04890194
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04605996
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04355103
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.04120049
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97299107
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93258527
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90066024
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89355390
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.88299236
28CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.86083967
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85724798
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.83381095
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83204775
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82090689
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78258121
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75625877
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73791983
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.72183570
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.71435892
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.70724561
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.68712987
40GATA1_22025678_ChIP-Seq_K562_Human1.68397455
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67524100
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65996962
43RNF2_27304074_Chip-Seq_NSC_Mouse1.64683926
44VDR_23849224_ChIP-Seq_CD4+_Human1.62770071
45ZNF263_19887448_ChIP-Seq_K562_Human1.61102262
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.57710086
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57326504
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57073867
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57023035
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56297622
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54294998
52GBX2_23144817_ChIP-Seq_PC3_Human1.54201145
53CTCF_18555785_ChIP-Seq_MESCs_Mouse1.51087134
54MYC_18940864_ChIP-ChIP_HL60_Human1.50987333
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50298247
56TTF2_22483619_ChIP-Seq_HELA_Human1.48955391
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44172140
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44014067
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.42863695
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.39241614
61CTCF_27219007_Chip-Seq_Bcells_Human1.38469179
62VDR_22108803_ChIP-Seq_LS180_Human1.37962088
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36061821
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36061821
65ZNF274_21170338_ChIP-Seq_K562_Hela1.35675497
66DCP1A_22483619_ChIP-Seq_HELA_Human1.34003154
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.33740481
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32243509
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31876946
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.30055440
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.29817499
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28694359
73TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.28005382
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27781941
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27263091
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.23423528
77CTCF_20526341_ChIP-Seq_ESCs_Human1.23158221
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21936482
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.21355434
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21351361
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21137584
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20545357
83GABP_19822575_ChIP-Seq_HepG2_Human1.19658384
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19483248
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17689040
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16721807
87XRN2_22483619_ChIP-Seq_HELA_Human1.15747808
88MYC_19030024_ChIP-ChIP_MESCs_Mouse1.14827001
89REST_19997604_ChIP-ChIP_NEURONS_Mouse1.14577841
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.14339924
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12813541
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12733294
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.12663924
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12504871
95TET1_21490601_ChIP-Seq_MESCs_Mouse1.11919193
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10293638
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10291481
98IRF1_19129219_ChIP-ChIP_H3396_Human1.09652863
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08147460
100FOXP3_21729870_ChIP-Seq_TREG_Human1.08136666
101TAF15_26573619_Chip-Seq_HEK293_Human1.05179466
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.04749453
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04486908
104AR_21572438_ChIP-Seq_LNCaP_Human1.04416580
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03645882
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03577576
107RNF2_27304074_Chip-Seq_ESCs_Mouse1.03500343
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03435363
109* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02822664
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.02511128
111SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02402741
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02204990
113SMC4_20622854_ChIP-Seq_HELA_Human1.01913032
114TP53_22573176_ChIP-Seq_HFKS_Human1.00564577
115ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00455355
116LXR_22292898_ChIP-Seq_THP-1_Human1.00242583
117ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98989340
118SOX2_16153702_ChIP-ChIP_HESCs_Human0.98326224
119LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97962714
120P68_20966046_ChIP-Seq_HELA_Human0.97312673
121KDM5A_27292631_Chip-Seq_BREAST_Human0.96676735
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96496905
123SA1_27219007_Chip-Seq_Bcells_Human0.96380999
124DROSHA_22980978_ChIP-Seq_HELA_Human0.96355917
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95899830
126CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95736687
127IGF1R_20145208_ChIP-Seq_DFB_Human0.95069376
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93740959
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.92954886
130KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92507457
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.92401091
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91854140
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.91274455
134MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91263001
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89892872
136EOMES_21245162_ChIP-Seq_HESCs_Human0.89724279
137ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89325651
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88983134
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88983134
140HTT_18923047_ChIP-ChIP_STHdh_Human0.83817206
141BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83410021
142SRF_21415370_ChIP-Seq_HL-1_Mouse0.83355618
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82546638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.59886274
2MP0003880_abnormal_central_pattern4.59196032
3MP0003635_abnormal_synaptic_transmissio3.41291333
4MP0004270_analgesia3.35229864
5MP0001529_abnormal_vocalization2.97372282
6MP0003329_amyloid_beta_deposits2.77657964
7MP0002064_seizures2.75418942
8MP0001968_abnormal_touch/_nociception2.73815406
9MP0009745_abnormal_behavioral_response2.69692939
10MP0002272_abnormal_nervous_system2.64279496
11MP0002734_abnormal_mechanical_nocicepti2.55566271
12MP0002063_abnormal_learning/memory/cond2.50460146
13MP0002822_catalepsy2.45845914
14MP0009379_abnormal_foot_pigmentation2.45462989
15MP0002909_abnormal_adrenal_gland2.41425034
16MP0005423_abnormal_somatic_nervous2.33058365
17MP0009046_muscle_twitch2.29415232
18MP0003136_yellow_coat_color2.25174458
19MP0006276_abnormal_autonomic_nervous2.23692075
20MP0002572_abnormal_emotion/affect_behav2.16368296
21MP0002733_abnormal_thermal_nociception2.15043866
22MP0002736_abnormal_nociception_after2.08901258
23MP0001970_abnormal_pain_threshold2.07634153
24MP0004142_abnormal_muscle_tone2.05880885
25MP0001188_hyperpigmentation1.96864723
26MP0001905_abnormal_dopamine_level1.95964485
27MP0001486_abnormal_startle_reflex1.95615316
28MP0002837_dystrophic_cardiac_calcinosis1.92933814
29MP0001501_abnormal_sleep_pattern1.90823586
30MP0001440_abnormal_grooming_behavior1.83895369
31MP0001984_abnormal_olfaction1.78082695
32MP0008058_abnormal_DNA_repair1.77321782
33MP0006072_abnormal_retinal_apoptosis1.71102759
34MP0002735_abnormal_chemical_nociception1.70652395
35MP0002067_abnormal_sensory_capabilities1.70531490
36MP0008569_lethality_at_weaning1.65740999
37MP0000013_abnormal_adipose_tissue1.65357273
38MP0003656_abnormal_erythrocyte_physiolo1.60553719
39MP0004924_abnormal_behavior1.60547522
40MP0005386_behavior/neurological_phenoty1.60547522
41MP0003787_abnormal_imprinting1.57941305
42MP0000569_abnormal_digit_pigmentation1.55328504
43MP0002184_abnormal_innervation1.54772250
44MP0003283_abnormal_digestive_organ1.54311289
45MP0005646_abnormal_pituitary_gland1.53582395
46MP0005645_abnormal_hypothalamus_physiol1.51832557
47MP0004811_abnormal_neuron_physiology1.51565780
48MP0003122_maternal_imprinting1.48450357
49MP0000955_abnormal_spinal_cord1.47659540
50MP0004043_abnormal_pH_regulation1.45955282
51MP0003890_abnormal_embryonic-extraembry1.42959733
52MP0002229_neurodegeneration1.36681710
53MP0002066_abnormal_motor_capabilities/c1.35035691
54MP0002557_abnormal_social/conspecific_i1.33048984
55MP0003123_paternal_imprinting1.29703075
56MP0005410_abnormal_fertilization1.29612275
57MP0002882_abnormal_neuron_morphology1.28602361
58MP0001502_abnormal_circadian_rhythm1.25254097
59MP0008872_abnormal_physiological_respon1.25001946
60MP0000920_abnormal_myelination1.24928835
61MP0005551_abnormal_eye_electrophysiolog1.24184590
62MP0003879_abnormal_hair_cell1.22925232
63MP0003718_maternal_effect1.22704567
64MP0000747_muscle_weakness1.22085047
65MP0002638_abnormal_pupillary_reflex1.20965191
66MP0003693_abnormal_embryo_hatching1.18855051
67MP0004145_abnormal_muscle_electrophysio1.17536156
68MP0000604_amyloidosis1.15401896
69MP0004858_abnormal_nervous_system1.15183681
70MP0006036_abnormal_mitochondrial_physio1.12641607
71MP0002210_abnormal_sex_determination1.12537493
72MP0008995_early_reproductive_senescence1.12004266
73MP0004885_abnormal_endolymph1.11731536
74MP0010386_abnormal_urinary_bladder1.10761274
75MP0003633_abnormal_nervous_system1.10430566
76MP0003121_genomic_imprinting1.08521926
77MP0000566_synostosis1.08502433
78MP0005379_endocrine/exocrine_gland_phen1.06915298
79MP0003077_abnormal_cell_cycle1.04031240
80MP0001929_abnormal_gametogenesis1.03021893
81MP0004147_increased_porphyrin_level1.02661816
82MP0002277_abnormal_respiratory_mucosa1.00159481
83MP0002102_abnormal_ear_morphology1.00092091
84MP0002653_abnormal_ependyma_morphology0.99588506
85MP0003690_abnormal_glial_cell0.98176868
86MP0003634_abnormal_glial_cell0.97539075
87MP0003698_abnormal_male_reproductive0.97245344
88MP0005083_abnormal_biliary_tract0.97225107
89MP0010234_abnormal_vibrissa_follicle0.95356508
90MP0003631_nervous_system_phenotype0.93938898
91MP0005535_abnormal_body_temperature0.93463964
92MP0008260_abnormal_autophagy0.91476233
93MP0001944_abnormal_pancreas_morphology0.90497136
94MP0000778_abnormal_nervous_system0.88611364
95MP0002693_abnormal_pancreas_physiology0.87906450
96MP0002069_abnormal_eating/drinking_beha0.87458139
97MP0006035_abnormal_mitochondrial_morpho0.87094699
98MP0000631_abnormal_neuroendocrine_gland0.85228260
99MP0002152_abnormal_brain_morphology0.84657050
100MP0001765_abnormal_ion_homeostasis0.83927789
101MP0010094_abnormal_chromosome_stability0.83445293
102MP0009780_abnormal_chondrocyte_physiolo0.83372738
103MP0005636_abnormal_mineral_homeostasis0.81671599
104MP0001963_abnormal_hearing_physiology0.81555863
105MP0003221_abnormal_cardiomyocyte_apopto0.80918324
106MP0005394_taste/olfaction_phenotype0.80040524
107MP0005499_abnormal_olfactory_system0.80040524
108MP0000639_abnormal_adrenal_gland0.78154083
109MP0008877_abnormal_DNA_methylation0.77656546
110MP0000751_myopathy0.76695787
111MP0002234_abnormal_pharynx_morphology0.76471237
112MP0001986_abnormal_taste_sensitivity0.76279238
113MP0003111_abnormal_nucleus_morphology0.76053682
114MP0002161_abnormal_fertility/fecundity0.75541342
115MP0000015_abnormal_ear_pigmentation0.75534221
116MP0002752_abnormal_somatic_nervous0.75506330
117MP0008961_abnormal_basal_metabolism0.74730500
118MP0001145_abnormal_male_reproductive0.74432258
119MP0000026_abnormal_inner_ear0.73745769
120MP0001664_abnormal_digestion0.73047687
121MP0003186_abnormal_redox_activity0.72654425
122MP0005253_abnormal_eye_physiology0.71570068
123MP0004215_abnormal_myocardial_fiber0.71089096
124MP0000653_abnormal_sex_gland0.69736247
125MP0003861_abnormal_nervous_system0.68675246
126MP0002078_abnormal_glucose_homeostasis0.67195320
127MP0003632_abnormal_nervous_system0.66461461
128MP0004742_abnormal_vestibular_system0.65933375
129MP0002249_abnormal_larynx_morphology0.65454015
130MP0008874_decreased_physiological_sensi0.64821135
131MP0002095_abnormal_skin_pigmentation0.63954759
132MP0000462_abnormal_digestive_system0.62840338

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.15697362
2Focal motor seizures (HP:0011153)4.58398355
3Visual hallucinations (HP:0002367)4.35994203
4Delusions (HP:0000746)3.57413409
5Neurofibrillary tangles (HP:0002185)3.55200798
6Cerebral hypomyelination (HP:0006808)3.45621258
7Neuroendocrine neoplasm (HP:0100634)3.30716483
8Ankle clonus (HP:0011448)3.26986659
9Supranuclear gaze palsy (HP:0000605)3.26716020
10Cerebral inclusion bodies (HP:0100314)3.23820333
11Pheochromocytoma (HP:0002666)3.21843889
12Focal seizures (HP:0007359)3.21427024
13Absence seizures (HP:0002121)3.13768674
14Anxiety (HP:0000739)3.00606653
15Depression (HP:0000716)2.96625201
16Acute necrotizing encephalopathy (HP:0006965)2.95300613
17Abnormal mitochondria in muscle tissue (HP:0008316)2.92667338
18Atonic seizures (HP:0010819)2.91937902
19Cholecystitis (HP:0001082)2.88730042
20Abnormal gallbladder physiology (HP:0012438)2.88730042
21Retinal dysplasia (HP:0007973)2.86656964
22Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.85246273
23Generalized tonic-clonic seizures (HP:0002069)2.79099260
24Dialeptic seizures (HP:0011146)2.77551637
25CNS hypomyelination (HP:0003429)2.73853586
26Cortical dysplasia (HP:0002539)2.72436949
27Epileptic encephalopathy (HP:0200134)2.67982229
28Spastic gait (HP:0002064)2.67180218
29Abnormal pupillary function (HP:0007686)2.65445108
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60065645
31Dysmetria (HP:0001310)2.57969783
32Mitochondrial inheritance (HP:0001427)2.56805231
33Emotional lability (HP:0000712)2.56739978
34Insomnia (HP:0100785)2.55544879
35Type II lissencephaly (HP:0007260)2.55289820
36Status epilepticus (HP:0002133)2.51300265
37Acute encephalopathy (HP:0006846)2.47960584
38Hepatocellular necrosis (HP:0001404)2.46568531
39Agnosia (HP:0010524)2.44276160
40Abnormality of the labia minora (HP:0012880)2.43393543
41Papilledema (HP:0001085)2.40806460
42Poor suck (HP:0002033)2.40362290
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.39595405
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39043791
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39043791
46Limb dystonia (HP:0002451)2.39000989
47Atrophy/Degeneration involving motor neurons (HP:0007373)2.37830111
48Progressive macrocephaly (HP:0004481)2.36328459
49Truncal ataxia (HP:0002078)2.33111607
50Generalized myoclonic seizures (HP:0002123)2.30577736
51Clonus (HP:0002169)2.29924797
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28710538
53Abnormality of the anterior horn cell (HP:0006802)2.27603169
54Degeneration of anterior horn cells (HP:0002398)2.27603169
55Action tremor (HP:0002345)2.27280900
56Unsteady gait (HP:0002317)2.27015979
57Shoulder girdle muscle weakness (HP:0003547)2.22089046
58Leukodystrophy (HP:0002415)2.19567281
59Increased CSF lactate (HP:0002490)2.18590860
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.16731130
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16731130
62Diplopia (HP:0000651)2.16351382
63Abnormality of binocular vision (HP:0011514)2.16351382
64EEG with generalized epileptiform discharges (HP:0011198)2.15571197
65Abnormal eating behavior (HP:0100738)2.15097447
66Optic nerve hypoplasia (HP:0000609)2.14595889
67Muscular hypotonia of the trunk (HP:0008936)2.12547956
68Urinary urgency (HP:0000012)2.12032878
69Neuronal loss in central nervous system (HP:0002529)2.11493472
70Bradykinesia (HP:0002067)2.11300596
71Global brain atrophy (HP:0002283)2.11242201
72Epileptiform EEG discharges (HP:0011182)2.11214002
73Abnormality of the corticospinal tract (HP:0002492)2.09476128
74Rigidity (HP:0002063)2.08947059
75Dysdiadochokinesis (HP:0002075)2.08869374
76Annular pancreas (HP:0001734)2.07901072
77Scanning speech (HP:0002168)2.07620571
78Ventricular fibrillation (HP:0001663)2.07018307
79Psychosis (HP:0000709)2.05908726
80Neoplasm of the peripheral nervous system (HP:0100007)2.05216961
81Spastic tetraplegia (HP:0002510)2.04540486
82Choreoathetosis (HP:0001266)2.03942036
83Split foot (HP:0001839)2.03328377
84Progressive inability to walk (HP:0002505)2.03089537
85Termporal pattern (HP:0011008)2.03002944
86Insidious onset (HP:0003587)2.03002944
87Septo-optic dysplasia (HP:0100842)2.02983793
88Progressive cerebellar ataxia (HP:0002073)2.02452928
89Hypsarrhythmia (HP:0002521)2.02359572
90Hepatic necrosis (HP:0002605)2.01188045
91Peripheral hypomyelination (HP:0007182)2.00611701
92Postnatal microcephaly (HP:0005484)1.99456843
93Dysautonomia (HP:0002459)1.99452309
94Abnormality of calcium-phosphate metabolism (HP:0100530)1.97506516
95Postural instability (HP:0002172)1.96680565
96Spastic tetraparesis (HP:0001285)1.96534897
97Intention tremor (HP:0002080)1.96447187
98Pallor (HP:0000980)1.96246029
99Hemiparesis (HP:0001269)1.95843576
100Macrocytic anemia (HP:0001972)1.95590815
101Megalencephaly (HP:0001355)1.94262088
102Pelvic girdle muscle weakness (HP:0003749)1.94158142
103Diminished motivation (HP:0000745)1.92346429
104Increased intramyocellular lipid droplets (HP:0012240)1.92064847
105Maternal diabetes (HP:0009800)1.91523707
106Achilles tendon contracture (HP:0001771)1.91087567
107Absent septum pellucidum (HP:0001331)1.90816081
108Mutism (HP:0002300)1.89954588
109Impaired vibration sensation in the lower limbs (HP:0002166)1.88881140
110Lactic acidosis (HP:0003128)1.88768667
111Apathy (HP:0000741)1.88547049
112Amyotrophic lateral sclerosis (HP:0007354)1.88506404
113Progressive neurologic deterioration (HP:0002344)1.85767548
114Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85268015
115Abnormal number of erythroid precursors (HP:0012131)1.85136308
116Abnormal gallbladder morphology (HP:0012437)1.84883022
117Abnormality of the hip-girdle musculature (HP:0001445)1.84674522
118Abnormality of the musculature of the pelvis (HP:0001469)1.84674522
119Reticulocytopenia (HP:0001896)1.84119514
120Febrile seizures (HP:0002373)1.83821154
121Progressive muscle weakness (HP:0003323)1.83253263
122Craniofacial dystonia (HP:0012179)1.82351267
123Focal dystonia (HP:0004373)1.82076329
124Cortical visual impairment (HP:0100704)1.81005287
125Dysphonia (HP:0001618)1.80842579
126Abnormality of alanine metabolism (HP:0010916)1.80749159
127Hyperalaninemia (HP:0003348)1.80749159
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80749159
129Polyphagia (HP:0002591)1.80249205
130Poor eye contact (HP:0000817)1.79529556
131Cerebellar atrophy (HP:0001272)1.77905659
132Urinary bladder sphincter dysfunction (HP:0002839)1.76773631
133Increased hepatocellular lipid droplets (HP:0006565)1.75919200
134Abnormal hemoglobin (HP:0011902)1.70228806
135Incomplete penetrance (HP:0003829)1.70053861
136Abnormality of cells of the erythroid lineage (HP:0012130)1.69730305
137Rimmed vacuoles (HP:0003805)1.69028728
138Delayed myelination (HP:0012448)1.66722775
139Morphological abnormality of the pyramidal tract (HP:0002062)1.66412966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.96463263
2NTRK33.43151404
3KSR23.08293041
4CDK192.98101970
5NME12.84240666
6PRKD32.59879371
7ARAF2.57265357
8EPHA42.44512401
9PNCK2.44170859
10MAP3K122.15145135
11TSSK62.14037334
12MINK12.12791288
13NTRK12.00748802
14SCYL21.98187404
15TESK21.92804286
16UHMK11.90012900
17MAP3K21.87771790
18MAP3K41.85721501
19DYRK31.75119994
20PAK61.74985775
21MAPKAPK51.74580676
22MARK11.74354828
23VRK11.68745166
24MAP2K41.55810522
25GRK51.55456020
26PINK11.42590748
27SRPK11.42172371
28STK161.37367735
29CASK1.36788077
30CDK51.32510963
31MAP2K71.31329687
32MAP3K131.28068969
33SIK21.28059957
34MAPK151.27925730
35MAP3K11.26664147
36BUB11.26612968
37CDK141.26142615
38BRAF1.25404666
39DAPK21.25093335
40PLK31.24292427
41PLK21.21874901
42MAP3K111.18463130
43STK391.16595433
44CAMK2B1.16124831
45CDK151.11993111
46OXSR11.10530980
47CDK181.08313686
48CDK11A1.06399163
49CAMKK21.04969962
50KSR11.04630212
51CAMKK11.04152844
52RAF11.03729764
53WNK41.02685506
54NTRK21.02356952
55LIMK11.02038076
56CAMK2G1.01358750
57PHKG10.98881535
58PHKG20.98881535
59PASK0.90639636
60MAPKAPK30.89591944
61CAMK2D0.89147423
62PRKCG0.88095006
63DAPK10.87201422
64CDC70.85761062
65CAMK2A0.85560426
66ACVR1B0.84857968
67BRSK10.83462061
68MOS0.81463338
69WNK30.81115014
70TTK0.81012536
71PIM10.79228901
72FES0.78426038
73NEK10.77786038
74TESK10.77729529
75CSNK1G20.76802782
76CCNB10.76587416
77PBK0.75877218
78RIPK40.74937063
79RET0.74905297
80VRK20.74292088
81WEE10.74120830
82DAPK30.73019509
83PLK10.72735119
84MAP3K50.72091593
85MAP2K20.71864399
86DYRK1A0.70218137
87AURKA0.69762696
88RPS6KA50.69298878
89TLK10.68454109
90HIPK20.66807713
91CAMK40.66666129
92PAK30.66018296
93CSNK1G30.65744868
94TYRO30.64123558
95TRIM280.62875099
96MAPK130.62317768
97RPS6KA40.61252089
98TAOK20.59358317
99CAMK10.59216527
100MAP2K10.58484658
101PKN10.57411253
102CSNK1A1L0.56971557
103CSNK1G10.55384442
104PDK10.52464095
105DYRK1B0.52035093
106EIF2AK10.51911443
107PRKCH0.49788231
108PDK30.49556663
109PDK40.49556663
110BCKDK0.48950730
111CDK30.48229271
112MAP3K60.48021848
113TAOK30.48014284
114LATS20.47988457
115PDPK10.47670010
116FGR0.45708958
117TNIK0.45050766
118CAMK1D0.43415325
119STK110.42665019
120GRK70.40703352
121BCR0.40383754
122LMTK20.40096244
123CSNK1E0.38457878
124ALK0.38172709
125IRAK20.37072553
126DYRK20.37068270
127TNK20.36853806
128SGK10.36692562
129TAOK10.36664860
130CHEK20.36507643
131ZAK0.36450187
132PRPF4B0.35897294
133BMPR20.34888223
134STK40.34834716
135ROCK20.34638315
136GRK60.33752616
137MAPK100.32631452
138SGK4940.32355911
139SGK2230.32355911
140PRKACA0.30362119

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.53550330
2Oxidative phosphorylation_Homo sapiens_hsa001903.07173959
3Parkinsons disease_Homo sapiens_hsa050122.83338486
4Nicotine addiction_Homo sapiens_hsa050332.71736148
5GABAergic synapse_Homo sapiens_hsa047272.54114313
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47372903
7Mismatch repair_Homo sapiens_hsa034302.38154487
8Insulin secretion_Homo sapiens_hsa049112.15612727
9Protein export_Homo sapiens_hsa030602.12672363
10Alzheimers disease_Homo sapiens_hsa050102.11701962
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10235652
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.10124656
13Amphetamine addiction_Homo sapiens_hsa050312.04624185
14Long-term potentiation_Homo sapiens_hsa047202.04100639
15Collecting duct acid secretion_Homo sapiens_hsa049661.93768205
16Cardiac muscle contraction_Homo sapiens_hsa042601.92273366
17Dopaminergic synapse_Homo sapiens_hsa047281.90157710
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88565679
19Morphine addiction_Homo sapiens_hsa050321.88038602
20Spliceosome_Homo sapiens_hsa030401.86172361
21Circadian entrainment_Homo sapiens_hsa047131.86015136
22Nitrogen metabolism_Homo sapiens_hsa009101.82700228
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.81882454
24DNA replication_Homo sapiens_hsa030301.81156226
25Huntingtons disease_Homo sapiens_hsa050161.80132218
26Vibrio cholerae infection_Homo sapiens_hsa051101.75801319
27Cocaine addiction_Homo sapiens_hsa050301.73725040
28Olfactory transduction_Homo sapiens_hsa047401.72696976
29Base excision repair_Homo sapiens_hsa034101.71887579
30Glutamatergic synapse_Homo sapiens_hsa047241.70614971
31Serotonergic synapse_Homo sapiens_hsa047261.49624404
32Taste transduction_Homo sapiens_hsa047421.40875142
33Salivary secretion_Homo sapiens_hsa049701.37933304
34Cholinergic synapse_Homo sapiens_hsa047251.35816502
35Long-term depression_Homo sapiens_hsa047301.29796349
36Gastric acid secretion_Homo sapiens_hsa049711.29555787
37Cell cycle_Homo sapiens_hsa041101.24994307
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20612094
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20385606
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17776108
41Renin secretion_Homo sapiens_hsa049241.17518342
42Proteasome_Homo sapiens_hsa030501.17324424
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15587495
44Basal transcription factors_Homo sapiens_hsa030221.14129611
45Nucleotide excision repair_Homo sapiens_hsa034201.13306337
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13085805
47Folate biosynthesis_Homo sapiens_hsa007901.12508860
48Fanconi anemia pathway_Homo sapiens_hsa034601.11920764
49Ribosome_Homo sapiens_hsa030101.10250530
50Oocyte meiosis_Homo sapiens_hsa041141.09132737
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08761720
52Vitamin B6 metabolism_Homo sapiens_hsa007501.08690907
53Sulfur relay system_Homo sapiens_hsa041221.08315227
54Alcoholism_Homo sapiens_hsa050341.06048993
55Sulfur metabolism_Homo sapiens_hsa009201.04157326
56mRNA surveillance pathway_Homo sapiens_hsa030151.00673237
57Gap junction_Homo sapiens_hsa045401.00164353
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00041967
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00004667
60Oxytocin signaling pathway_Homo sapiens_hsa049210.97024896
61Homologous recombination_Homo sapiens_hsa034400.96927244
62GnRH signaling pathway_Homo sapiens_hsa049120.92569269
63Pancreatic secretion_Homo sapiens_hsa049720.92211636
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92202951
65RNA degradation_Homo sapiens_hsa030180.91088640
66RNA transport_Homo sapiens_hsa030130.86212466
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85334034
68Calcium signaling pathway_Homo sapiens_hsa040200.85278542
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83870367
70Estrogen signaling pathway_Homo sapiens_hsa049150.81661022
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76561053
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75871889
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75037137
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.73655251
75Prion diseases_Homo sapiens_hsa050200.72429924
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67963107
77Pyrimidine metabolism_Homo sapiens_hsa002400.66297489
78Biosynthesis of amino acids_Homo sapiens_hsa012300.65922512
79Pyruvate metabolism_Homo sapiens_hsa006200.65539476
80Regulation of autophagy_Homo sapiens_hsa041400.65462574
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.65093314
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.65082294
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.64192420
84Thyroid hormone synthesis_Homo sapiens_hsa049180.63806080
85Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61874541
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61687626
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61067511
88Butanoate metabolism_Homo sapiens_hsa006500.58125007
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57184716
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.56071303
91cAMP signaling pathway_Homo sapiens_hsa040240.55936628
92RNA polymerase_Homo sapiens_hsa030200.55724312
93Type II diabetes mellitus_Homo sapiens_hsa049300.54159555
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53166977
95Selenocompound metabolism_Homo sapiens_hsa004500.52941127
96Fatty acid elongation_Homo sapiens_hsa000620.52915496
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52058741
98Glucagon signaling pathway_Homo sapiens_hsa049220.48697107
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48667654
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48662855
101Melanogenesis_Homo sapiens_hsa049160.48414026
102Ether lipid metabolism_Homo sapiens_hsa005650.48310223
103N-Glycan biosynthesis_Homo sapiens_hsa005100.46641756
104Carbon metabolism_Homo sapiens_hsa012000.44951998
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44760640
106VEGF signaling pathway_Homo sapiens_hsa043700.44163358
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43994833
108Circadian rhythm_Homo sapiens_hsa047100.43963230
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42497228
110beta-Alanine metabolism_Homo sapiens_hsa004100.40789932
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39775295
112Linoleic acid metabolism_Homo sapiens_hsa005910.37693883
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.37438757
114Metabolic pathways_Homo sapiens_hsa011000.36667373
115Endocytosis_Homo sapiens_hsa041440.35875676
116Phototransduction_Homo sapiens_hsa047440.34720964
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33973437
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33803439
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33669691
120Purine metabolism_Homo sapiens_hsa002300.32428210
121ErbB signaling pathway_Homo sapiens_hsa040120.32242178
122Phagosome_Homo sapiens_hsa041450.32057927
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.31390133
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31223395
125Fructose and mannose metabolism_Homo sapiens_hsa000510.30676108
126Arginine and proline metabolism_Homo sapiens_hsa003300.30314686
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29958964
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27931399
129MAPK signaling pathway_Homo sapiens_hsa040100.27769724
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26858230
131Epstein-Barr virus infection_Homo sapiens_hsa051690.25447174

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