PITPNA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by phosphoinositide-3-kinase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.67283647
2locomotory exploration behavior (GO:0035641)5.08624843
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.83727047
4synaptic vesicle exocytosis (GO:0016079)4.73245457
5glutamate secretion (GO:0014047)4.39708794
6sodium ion export (GO:0071436)4.35329631
7regulation of synaptic vesicle exocytosis (GO:2000300)4.23432178
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22479451
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.07117256
10cellular potassium ion homeostasis (GO:0030007)4.02852802
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.92222064
12vocalization behavior (GO:0071625)3.88622892
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.86025529
14negative regulation of cell killing (GO:0031342)3.86025529
15layer formation in cerebral cortex (GO:0021819)3.85356425
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80051582
17exploration behavior (GO:0035640)3.69978385
18regulation of synaptic vesicle transport (GO:1902803)3.68281994
19regulation of glutamate receptor signaling pathway (GO:1900449)3.62476470
20regulation of ARF protein signal transduction (GO:0032012)3.57134070
21regulation of synapse structural plasticity (GO:0051823)3.57046161
22neurotransmitter secretion (GO:0007269)3.56356622
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.53479555
24proline transport (GO:0015824)3.52864953
25barbed-end actin filament capping (GO:0051016)3.50450116
26negative regulation of erythrocyte differentiation (GO:0045647)3.44679842
27neuronal action potential propagation (GO:0019227)3.43695974
28activation of protein kinase A activity (GO:0034199)3.40742387
29regulation of clathrin-mediated endocytosis (GO:2000369)3.40438802
30clathrin coat assembly (GO:0048268)3.36821118
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32937947
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.27675747
33positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.22143515
34G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.19353981
35negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.18349669
36regulation of neuronal synaptic plasticity (GO:0048168)3.15844426
37protein localization to synapse (GO:0035418)3.15549988
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07293009
39regulation of NFAT protein import into nucleus (GO:0051532)3.04803982
40nerve growth factor signaling pathway (GO:0038180)3.04325644
41cell-cell junction maintenance (GO:0045217)2.97837445
42neuromuscular process controlling balance (GO:0050885)2.96294507
43lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93026440
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.91461843
45response to peptidoglycan (GO:0032494)2.91329604
46gamma-aminobutyric acid transport (GO:0015812)2.91102734
47protein localization to endosome (GO:0036010)2.88096344
48vesicle transport along microtubule (GO:0047496)2.87962308
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87057314
50synaptic vesicle endocytosis (GO:0048488)2.84678781
51positive regulation of cellular amide metabolic process (GO:0034250)2.84452091
52regulation of early endosome to late endosome transport (GO:2000641)2.83845308
53positive regulation of Cdc42 GTPase activity (GO:0043089)2.83307534
54positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.82421621
55epithelial cell differentiation involved in prostate gland development (GO:0060742)2.80878670
56potassium ion import (GO:0010107)2.79569111
57positive regulation of receptor recycling (GO:0001921)2.76737781
58positive regulation of fibroblast migration (GO:0010763)2.76635911
59long-term memory (GO:0007616)2.76485234
60virion attachment to host cell (GO:0019062)2.76337433
61adhesion of symbiont to host cell (GO:0044650)2.76337433
62glutamate receptor signaling pathway (GO:0007215)2.76195260
63cellular response to nerve growth factor stimulus (GO:1990090)2.75325279
64response to nerve growth factor (GO:1990089)2.75325279
65regulation of ARF GTPase activity (GO:0032312)2.73973503
66negative regulation of toll-like receptor signaling pathway (GO:0034122)2.72586055
67cell communication by electrical coupling (GO:0010644)2.72315997
68regulation of excitatory postsynaptic membrane potential (GO:0060079)2.72201789
69dendritic spine morphogenesis (GO:0060997)2.71581630
70adhesion of symbiont to host (GO:0044406)2.71137787
71neurotransmitter transport (GO:0006836)2.70278964
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.68269237
73glycosphingolipid catabolic process (GO:0046479)2.67266746
74neuron cell-cell adhesion (GO:0007158)2.65697082
75dendrite morphogenesis (GO:0048813)2.65242358
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65093319
77cellular response to thyroid hormone stimulus (GO:0097067)2.65039296
78regulation of synaptic plasticity (GO:0048167)2.63825987
79cortical actin cytoskeleton organization (GO:0030866)2.63088097
80modulation by symbiont of host cellular process (GO:0044068)2.62131533
81cerebellar Purkinje cell differentiation (GO:0021702)2.61014511
82amino acid import (GO:0043090)2.60821000
83regulation of dendritic spine morphogenesis (GO:0061001)2.60160546
84hormone catabolic process (GO:0042447)2.59608713
85positive regulation of membrane potential (GO:0045838)2.57685332
86cerebellar granule cell differentiation (GO:0021707)2.57469643
87regulation of T-helper 2 cell differentiation (GO:0045628)2.57091805
88signal complex assembly (GO:0007172)2.56343446
89positive regulation of synapse maturation (GO:0090129)2.56016241
90positive regulation by symbiont of host defense response (GO:0052509)2.55311971
91modulation by symbiont of host defense response (GO:0052031)2.55311971
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55311971
93modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55311971
94positive regulation by organism of defense response of other organism involved in symbiotic interact2.55311971
95modulation by symbiont of host immune response (GO:0052553)2.55311971
96positive regulation of protein dephosphorylation (GO:0035307)2.54473017
97semaphorin-plexin signaling pathway (GO:0071526)2.53180793
98regulation of postsynaptic membrane potential (GO:0060078)2.52752606
99axon cargo transport (GO:0008088)2.52116479
100negative regulation of microtubule polymerization (GO:0031115)2.52002862
101response to acidic pH (GO:0010447)2.51646337
102mating behavior (GO:0007617)2.51006349
103synaptic transmission, glutamatergic (GO:0035249)2.50578671
104regulation of neurotransmitter levels (GO:0001505)2.50287968
105regulation of podosome assembly (GO:0071801)2.49308770
106glycine transport (GO:0015816)2.49039327
107regulation of neurotransmitter secretion (GO:0046928)2.47943137
108cellular sodium ion homeostasis (GO:0006883)2.46533145
109negative regulation of interleukin-12 production (GO:0032695)2.46488847
110cortical cytoskeleton organization (GO:0030865)2.45524077
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.44289849
112organelle transport along microtubule (GO:0072384)2.44219738
113macrophage activation involved in immune response (GO:0002281)2.43676270
114peptidyl-tyrosine autophosphorylation (GO:0038083)2.41749682
115neuron-neuron synaptic transmission (GO:0007270)2.40953452
116adenosine receptor signaling pathway (GO:0001973)2.40486149
117neurotransmitter-gated ion channel clustering (GO:0072578)2.39897753
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.39513415
119L-amino acid import (GO:0043092)2.37996667
120hypotonic response (GO:0006971)2.37621677
121regulation of vesicle fusion (GO:0031338)2.37575629
122regulation of leukocyte degranulation (GO:0043300)2.37376074
123membrane repolarization (GO:0086009)2.37214960
124regulation of regulated secretory pathway (GO:1903305)2.35982352
125potassium ion homeostasis (GO:0055075)2.35839777
126regulation of dendritic spine development (GO:0060998)2.35816019
127glycolipid catabolic process (GO:0019377)2.35593584
128membrane depolarization during action potential (GO:0086010)2.35534587
129regulation of protein dephosphorylation (GO:0035304)2.34882731
130stress fiber assembly (GO:0043149)2.34006738
131negative regulation of synaptic transmission, GABAergic (GO:0032229)2.33334008
132apoptotic cell clearance (GO:0043277)2.31688565
133regulation of voltage-gated calcium channel activity (GO:1901385)2.31367344
134long-term synaptic potentiation (GO:0060291)2.29966415
135actin filament bundle assembly (GO:0051017)2.29861197
136actin filament bundle organization (GO:0061572)2.29861197
137regulation of vitamin D biosynthetic process (GO:0060556)2.29343878
138regulation of amyloid precursor protein catabolic process (GO:1902991)2.28516577
139regulation of B cell receptor signaling pathway (GO:0050855)2.28459660
140cerebellar Purkinje cell layer development (GO:0021680)2.27967635
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.27832962
142prepulse inhibition (GO:0060134)2.27723395
143endocytic recycling (GO:0032456)2.27406606
144neuromuscular process controlling posture (GO:0050884)2.27005922
145response to histamine (GO:0034776)2.26684978
146positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.25896318
147activation of MAPKKK activity (GO:0000185)2.25427405
148mannose metabolic process (GO:0006013)2.25330486
149response to laminar fluid shear stress (GO:0034616)2.25100774
150protein retention in ER lumen (GO:0006621)2.22227968
151detection of molecule of bacterial origin (GO:0032490)2.21632836
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.20433679
153regulation of vitamin metabolic process (GO:0030656)2.19818360
154regulation of membrane protein ectodomain proteolysis (GO:0051043)2.19740642
155positive regulation of Rap GTPase activity (GO:0032854)2.17927182
156angiotensin maturation (GO:0002003)2.17201507
157skin morphogenesis (GO:0043589)2.16003861
158regulation of defense response to virus by virus (GO:0050690)2.14542091
159modulation by virus of host morphology or physiology (GO:0019048)2.14146366
160regulation of lipid kinase activity (GO:0043550)2.12910128
161adherens junction assembly (GO:0034333)2.10428202
162detection of other organism (GO:0098543)2.10293639
163cellular copper ion homeostasis (GO:0006878)2.09305943
164positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.08279547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.78444998
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.96253848
3IKZF1_21737484_ChIP-ChIP_HCT116_Human2.54869242
4DROSHA_22980978_ChIP-Seq_HELA_Human2.38570797
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.34413384
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29520517
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23883903
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22305738
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.19517323
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.12761151
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09144552
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06396616
13* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06043399
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03044337
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01944028
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00318023
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99496816
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99496816
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93186343
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90978984
21REST_21632747_ChIP-Seq_MESCs_Mouse1.87518056
22KDM2B_26808549_Chip-Seq_DND41_Human1.78389136
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.77703747
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.77702766
25KDM2B_26808549_Chip-Seq_K562_Human1.74943050
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73453396
27CLOCK_20551151_ChIP-Seq_293T_Human1.71654896
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.69632639
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67357993
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.62928003
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61543957
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59305126
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59274905
34AR_21572438_ChIP-Seq_LNCaP_Human1.56910574
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56762896
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56612990
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56234724
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.55221427
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54932675
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.52811203
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.50805866
42* SPI1_23127762_ChIP-Seq_K562_Human1.50373476
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.50250902
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.50084874
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48060658
46EZH2_27294783_Chip-Seq_ESCs_Mouse1.46945755
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45026735
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44709029
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.44695978
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44076671
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43707502
52* LXR_22292898_ChIP-Seq_THP-1_Human1.42631576
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.42213400
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40417014
55* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40181977
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39219950
57SMC4_20622854_ChIP-Seq_HELA_Human1.37963372
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37541592
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.36947322
60GBX2_23144817_ChIP-Seq_PC3_Human1.36441855
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32724905
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32606919
63* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31722045
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29990096
65TCF7_22412390_ChIP-Seq_EML_Mouse1.29810484
66* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29783868
67* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29048930
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29001848
69CREB1_26743006_Chip-Seq_LNCaP_Human1.28696329
70* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28519027
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26675329
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25001317
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.23754227
74RUNX_20019798_ChIP-Seq_JUKART_Human1.21813117
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21301395
76MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20667592
77ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20653932
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20504584
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20357937
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19524145
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.19277969
82NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19171177
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.18291796
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.16924428
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16762156
86RXR_22108803_ChIP-Seq_LS180_Human1.16547874
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15619778
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14834041
89* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14647439
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14560535
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.14125933
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.12870694
93* P68_20966046_ChIP-Seq_HELA_Human1.11723022
94* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11578128
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.11405368
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11309962
97BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10608174
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10402715
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09040597
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07231448
101GATA1_19941827_ChIP-Seq_MEL_Mouse1.07101235
102TP53_16413492_ChIP-PET_HCT116_Human1.06722251
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05989716
104RUNX1_22412390_ChIP-Seq_EML_Mouse1.05398647
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.04625127
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04446306
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03699704
108ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03566709
109ZNF263_19887448_ChIP-Seq_K562_Human1.02150144
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01492920
111CTCF_27219007_Chip-Seq_Bcells_Human1.01174855
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99694686
113VDR_24763502_ChIP-Seq_THP-1_Human0.99022708
114NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98449907
115VDR_24787735_ChIP-Seq_THP-1_Human0.98421512
116SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97849897
117PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96846583
118* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96817616
119* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96817616
120EED_16625203_ChIP-ChIP_MESCs_Mouse0.96794710
121JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96687534
122AHR_22903824_ChIP-Seq_MCF-7_Human0.96022619
123GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95768174
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95400711
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.95190261
126SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94947510
127SOX2_21211035_ChIP-Seq_LN229_Gbm0.94306688
128* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94290446
129* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94205666
130* ELK3_25401928_ChIP-Seq_HUVEC_Human0.93736101
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93640179
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93494473
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.93221048
134* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93209296
135AR_19668381_ChIP-Seq_PC3_Human0.93156976
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93093873
137SMAD4_21799915_ChIP-Seq_A2780_Human0.92891306
138NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92349186
139* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91750862
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88807529
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88605349
142VDR_21846776_ChIP-Seq_THP-1_Human0.87298234
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.86328033
144ZNF274_21170338_ChIP-Seq_K562_Hela0.85091417
145MYC_22102868_ChIP-Seq_BL_Human0.84904185
146RACK7_27058665_Chip-Seq_MCF-7_Human0.84647503
147TET1_21490601_ChIP-Seq_MESCs_Mouse0.84310119
148PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83745813
149EGR1_19032775_ChIP-ChIP_M12_Human0.83585970
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.81894525
151TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81686762

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.40721329
2MP0003303_peritoneal_inflammation3.76416084
3MP0003635_abnormal_synaptic_transmissio3.51155867
4MP0003880_abnormal_central_pattern2.94721451
5MP0004270_analgesia2.84105667
6MP0005409_darkened_coat_color2.69140614
7MP0009046_muscle_twitch2.60720190
8* MP0002064_seizures2.58777393
9MP0002063_abnormal_learning/memory/cond2.57950154
10MP0009745_abnormal_behavioral_response2.51039505
11MP0004510_myositis2.48702592
12MP0004858_abnormal_nervous_system2.47074449
13MP0001968_abnormal_touch/_nociception2.46683963
14MP0009840_abnormal_foam_cell2.44898694
15MP0008260_abnormal_autophagy2.36469246
16MP0003453_abnormal_keratinocyte_physiol2.24999509
17MP0000569_abnormal_digit_pigmentation2.22755766
18MP0003172_abnormal_lysosome_physiology2.16727644
19MP0001849_ear_inflammation2.14284800
20MP0005451_abnormal_body_composition2.11318717
21MP0003300_gastrointestinal_ulcer2.09928214
22MP0002735_abnormal_chemical_nociception2.06987577
23MP0003329_amyloid_beta_deposits2.04119791
24MP0002572_abnormal_emotion/affect_behav1.96953895
25MP0002734_abnormal_mechanical_nocicepti1.95097981
26MP0001501_abnormal_sleep_pattern1.94027449
27MP0008569_lethality_at_weaning1.92248240
28MP0002909_abnormal_adrenal_gland1.90800944
29MP0002733_abnormal_thermal_nociception1.88262718
30MP0002736_abnormal_nociception_after1.86093149
31MP0003075_altered_response_to1.84439291
32MP0003191_abnormal_cellular_cholesterol1.82978361
33MP0008004_abnormal_stomach_pH1.79230330
34MP0001970_abnormal_pain_threshold1.76679459
35MP0000604_amyloidosis1.75143499
36MP0005058_abnormal_lysosome_morphology1.73656529
37MP0004811_abnormal_neuron_physiology1.71801389
38MP0001440_abnormal_grooming_behavior1.64285240
39MP0002272_abnormal_nervous_system1.63888627
40MP0005423_abnormal_somatic_nervous1.63428536
41MP0009780_abnormal_chondrocyte_physiolo1.60357230
42MP0000343_altered_response_to1.52770944
43MP0003633_abnormal_nervous_system1.49139406
44MP0002877_abnormal_melanocyte_morpholog1.48828043
45MP0005167_abnormal_blood-brain_barrier1.48521370
46MP0002067_abnormal_sensory_capabilities1.48357113
47MP0001486_abnormal_startle_reflex1.45843608
48MP0002796_impaired_skin_barrier1.42711597
49MP0003690_abnormal_glial_cell1.39080456
50MP0000678_abnormal_parathyroid_gland1.38736329
51MP0003879_abnormal_hair_cell1.37057559
52MP0010234_abnormal_vibrissa_follicle1.36566784
53MP0005257_abnormal_intraocular_pressure1.35531074
54MP0003436_decreased_susceptibility_to1.32366802
55MP0005166_decreased_susceptibility_to1.31831934
56MP0003123_paternal_imprinting1.20357665
57MP0003183_abnormal_peptide_metabolism1.17622752
58MP0000858_altered_metastatic_potential1.16708530
59MP0005386_behavior/neurological_phenoty1.16112242
60MP0004924_abnormal_behavior1.16112242
61MP0009379_abnormal_foot_pigmentation1.16010988
62MP0002184_abnormal_innervation1.14731796
63MP0004130_abnormal_muscle_cell1.13620321
64MP0003705_abnormal_hypodermis_morpholog1.13389966
65MP0004185_abnormal_adipocyte_glucose1.12466140
66MP0003724_increased_susceptibility_to1.10337274
67MP0008961_abnormal_basal_metabolism1.10105242
68MP0001835_abnormal_antigen_presentation1.10098456
69MP0003631_nervous_system_phenotype1.09992825
70MP0008874_decreased_physiological_sensi1.09991353
71MP0002896_abnormal_bone_mineralization1.09189621
72MP0002822_catalepsy1.07885973
73MP0002557_abnormal_social/conspecific_i1.05950552
74* MP0002066_abnormal_motor_capabilities/c1.03930185
75MP0000751_myopathy1.03172680
76MP0002139_abnormal_hepatobiliary_system1.02757405
77MP0003045_fibrosis1.01716642
78MP0005000_abnormal_immune_tolerance1.01429420
79MP0006082_CNS_inflammation1.01247149
80MP0009785_altered_susceptibility_to0.99441163
81* MP0000955_abnormal_spinal_cord0.99327992
82MP0002419_abnormal_innate_immunity0.99268514
83MP0005666_abnormal_adipose_tissue0.99044319
84MP0000566_synostosis0.98490575
85MP0004264_abnormal_extraembryonic_tissu0.96391688
86MP0005623_abnormal_meninges_morphology0.93739127
87MP0002090_abnormal_vision0.93552984
88MP0005464_abnormal_platelet_physiology0.93087429
89MP0003091_abnormal_cell_migration0.91993997
90MP0010155_abnormal_intestine_physiology0.91074657
91MP0001790_abnormal_immune_system0.90893887
92MP0005387_immune_system_phenotype0.90893887
93MP0003634_abnormal_glial_cell0.90692706
94MP0005310_abnormal_salivary_gland0.89813754
95MP0005076_abnormal_cell_differentiation0.89532232
96MP0004484_altered_response_of0.88956029
97MP0003828_pulmonary_edema0.88514085
98* MP0002882_abnormal_neuron_morphology0.88473093
99MP0002148_abnormal_hypersensitivity_rea0.88130602
100MP0005023_abnormal_wound_healing0.87892984
101MP0001853_heart_inflammation0.86371873
102MP0003866_abnormal_defecation0.85538610
103MP0005248_abnormal_Harderian_gland0.85192205
104MP0003279_aneurysm0.85066414
105MP0000579_abnormal_nail_morphology0.83901899
106MP0000778_abnormal_nervous_system0.83469819
107* MP0000920_abnormal_myelination0.83403686
108MP0005375_adipose_tissue_phenotype0.83399737
109MP0002452_abnormal_antigen_presenting0.82579459
110MP0000015_abnormal_ear_pigmentation0.80852440
111MP0002089_abnormal_postnatal_growth/wei0.79581580
112MP0001348_abnormal_lacrimal_gland0.78928673
113MP0001533_abnormal_skeleton_physiology0.78871356
114MP0005174_abnormal_tail_pigmentation0.77021508
115MP0003566_abnormal_cell_adhesion0.75452678
116MP0000747_muscle_weakness0.74794271
117MP0004885_abnormal_endolymph0.74354668
118MP0004947_skin_inflammation0.73506030
119MP0001819_abnormal_immune_cell0.72862215
120MP0002420_abnormal_adaptive_immunity0.72156152
121MP0003632_abnormal_nervous_system0.71472885
122MP0010352_gastrointestinal_tract_polyps0.70986528
123MP0000685_abnormal_immune_system0.70377157
124MP0005025_abnormal_response_to0.70033659
125MP0002998_abnormal_bone_remodeling0.69880605
126MP0005390_skeleton_phenotype0.69795438
127MP0002723_abnormal_immune_serum0.69216279
128MP0001800_abnormal_humoral_immune0.68710436
129MP0004381_abnormal_hair_follicle0.67999736
130MP0002653_abnormal_ependyma_morphology0.67337041
131MP0003868_abnormal_feces_composition0.66605095
132MP0004233_abnormal_muscle_weight0.65580122
133MP0009278_abnormal_bone_marrow0.64523158
134MP0001216_abnormal_epidermal_layer0.63882321
135MP0001663_abnormal_digestive_system0.62739930
136MP0000767_abnormal_smooth_muscle0.62576565
137MP0001845_abnormal_inflammatory_respons0.62213355
138MP0003448_altered_tumor_morphology0.59884592
139MP0000013_abnormal_adipose_tissue0.59711397
140* MP0002229_neurodegeneration0.59593737
141MP0001958_emphysema0.58973934
142* MP0002152_abnormal_brain_morphology0.58734579
143MP0002133_abnormal_respiratory_system0.57628158

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.88849196
2Focal motor seizures (HP:0011153)4.84649509
3Visual hallucinations (HP:0002367)4.62107957
4Focal seizures (HP:0007359)4.02631546
5Papilledema (HP:0001085)4.00207527
6Supranuclear gaze palsy (HP:0000605)3.91367074
7Mutism (HP:0002300)3.78789094
8Action tremor (HP:0002345)3.44742493
9Progressive cerebellar ataxia (HP:0002073)3.21638043
10Increased cerebral lipofuscin (HP:0011813)3.14634436
11Atonic seizures (HP:0010819)3.09998162
12Inappropriate behavior (HP:0000719)2.90010857
13Absence seizures (HP:0002121)2.89509261
14Disinhibition (HP:0000734)2.89499452
15Apathy (HP:0000741)2.86548837
16Hyperparathyroidism (HP:0000843)2.84788580
17Systemic lupus erythematosus (HP:0002725)2.81445475
18Diminished motivation (HP:0000745)2.75982282
19Epileptic encephalopathy (HP:0200134)2.75574322
20Febrile seizures (HP:0002373)2.74988877
21Diplopia (HP:0000651)2.71152648
22Abnormality of binocular vision (HP:0011514)2.71152648
23Abnormality of macrophages (HP:0004311)2.69488556
24Segmental peripheral demyelination/remyelination (HP:0003481)2.66561261
25Postural instability (HP:0002172)2.66286608
26Nuclear cataract (HP:0100018)2.64658043
27Genetic anticipation (HP:0003743)2.61972991
28Dialeptic seizures (HP:0011146)2.59787754
29Depression (HP:0000716)2.58432773
30Generalized tonic-clonic seizures (HP:0002069)2.56786901
31Eczematoid dermatitis (HP:0000976)2.55639486
32Thin bony cortex (HP:0002753)2.51796034
33Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.50952394
34Ankle clonus (HP:0011448)2.46144362
35Dysostosis multiplex (HP:0000943)2.44812131
36Neuronal loss in central nervous system (HP:0002529)2.41338418
37Progressive inability to walk (HP:0002505)2.41241637
38Amyloidosis (HP:0011034)2.41036013
39Abnormal eating behavior (HP:0100738)2.40153397
40Recurrent abscess formation (HP:0002722)2.39892441
41Dysmetric saccades (HP:0000641)2.39320141
42Hemiplegia (HP:0002301)2.38587152
43Cerebral inclusion bodies (HP:0100314)2.35929604
44Urinary bladder sphincter dysfunction (HP:0002839)2.35827016
45Rapidly progressive (HP:0003678)2.32661333
46Lower limb asymmetry (HP:0100559)2.32321735
47Truncal ataxia (HP:0002078)2.32222910
48Obstructive sleep apnea (HP:0002870)2.31238582
49Annular pancreas (HP:0001734)2.29167564
50Abnormal social behavior (HP:0012433)2.28996717
51Impaired social interactions (HP:0000735)2.28996717
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.28366949
53Vertebral compression fractures (HP:0002953)2.26167404
54Achilles tendon contracture (HP:0001771)2.25429399
55Poor eye contact (HP:0000817)2.25260111
56Malnutrition (HP:0004395)2.23991774
57Dysmetria (HP:0001310)2.22431620
58Insidious onset (HP:0003587)2.21007108
59Termporal pattern (HP:0011008)2.21007108
60Impaired smooth pursuit (HP:0007772)2.20440881
61Broad-based gait (HP:0002136)2.18959254
62Hypercortisolism (HP:0001578)2.18733233
63Lower limb amyotrophy (HP:0007210)2.17783332
64Dysdiadochokinesis (HP:0002075)2.16690940
65Neurofibrillary tangles (HP:0002185)2.16675025
66Stereotypic behavior (HP:0000733)2.16447853
67Ventricular fibrillation (HP:0001663)2.14432868
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.13103930
69Urinary urgency (HP:0000012)2.12074578
70Frequent falls (HP:0002359)2.11193353
71Protrusio acetabuli (HP:0003179)2.10477196
72Recurrent bacterial skin infections (HP:0005406)2.08887280
73Gaze-evoked nystagmus (HP:0000640)2.08103922
74Vacuolated lymphocytes (HP:0001922)2.07946498
75Agitation (HP:0000713)2.07637119
76Impaired vibration sensation in the lower limbs (HP:0002166)2.06674412
77Insomnia (HP:0100785)2.05609456
78Macroorchidism (HP:0000053)2.03792300
79Abnormality of the nasal mucosa (HP:0000433)2.01306823
80Intention tremor (HP:0002080)2.00846157
81Mucopolysacchariduria (HP:0008155)2.00166153
82Urinary glycosaminoglycan excretion (HP:0003541)2.00166153
83Pointed chin (HP:0000307)1.98190134
84J-shaped sella turcica (HP:0002680)1.97845437
85Loss of speech (HP:0002371)1.97211189
86Amyotrophic lateral sclerosis (HP:0007354)1.96829499
87Turricephaly (HP:0000262)1.94214391
88Abnormality of ocular smooth pursuit (HP:0000617)1.93744281
89Pathologic fracture (HP:0002756)1.91363324
90Akinesia (HP:0002304)1.90515691
91Glomerulonephritis (HP:0000099)1.90213754
92Peripheral hypomyelination (HP:0007182)1.90137146
93Abnormality of the Achilles tendon (HP:0005109)1.89953094
94Cerebral aneurysm (HP:0004944)1.89580374
95Slow saccadic eye movements (HP:0000514)1.89432031
96Bradykinesia (HP:0002067)1.86749711
97Interstitial pulmonary disease (HP:0006530)1.85238634
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84174882
99Gingivitis (HP:0000230)1.83996052
100Abnormality of polysaccharide metabolism (HP:0011012)1.83459375
101Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83459375
102Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83459375
103Recurrent gram-negative bacterial infections (HP:0005420)1.82797217
104Cervical subluxation (HP:0003308)1.82471172
105Hematochezia (HP:0002573)1.81646656
106Anxiety (HP:0000739)1.80745349
107Cellulitis (HP:0100658)1.80017853
108Flat acetabular roof (HP:0003180)1.79731617
109Shallow orbits (HP:0000586)1.78328377
110Bundle branch block (HP:0011710)1.78090539
111Bone pain (HP:0002653)1.77710842
112Abnormality of glycolipid metabolism (HP:0010969)1.77710478
113Abnormality of liposaccharide metabolism (HP:0010968)1.77710478
114Abnormality of glycosphingolipid metabolism (HP:0004343)1.77710478
115Abnormality of the lower motor neuron (HP:0002366)1.77543751
116Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77174807
117Torticollis (HP:0000473)1.76288031
118Broad face (HP:0000283)1.76105488
119Axonal loss (HP:0003447)1.76050491
120Disproportionate tall stature (HP:0001519)1.76026664
121Thoracic kyphosis (HP:0002942)1.76025181
122Amblyopia (HP:0000646)1.75497179
123Polycythemia (HP:0001901)1.74929473
124Hyperacusis (HP:0010780)1.74833932
125Dementia (HP:0000726)1.73830080
126Ocular albinism (HP:0001107)1.73674886
127Distal upper limb amyotrophy (HP:0007149)1.72586187
128Upper limb amyotrophy (HP:0009129)1.72586187
129Increased IgE level (HP:0003212)1.72423295
130Long palpebral fissure (HP:0000637)1.70620863
131Polygenic inheritance (HP:0010982)1.70183746
132Spinal canal stenosis (HP:0003416)1.69249594
133Megalencephaly (HP:0001355)1.69177545
134Postural tremor (HP:0002174)1.68954394
135Decreased motor nerve conduction velocity (HP:0003431)1.68189816
136Upper motor neuron abnormality (HP:0002127)1.66100689
137Genu recurvatum (HP:0002816)1.65706183
138Centrally nucleated skeletal muscle fibers (HP:0003687)1.64648604
139Hand muscle atrophy (HP:0009130)1.64422427
140Mitral regurgitation (HP:0001653)1.64099065
141Short nail (HP:0001799)1.63892296
142Onion bulb formation (HP:0003383)1.63084574
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.63026147
144Increased connective tissue (HP:0009025)1.62510503
145Aneurysm (HP:0002617)1.62231447
146Nasal polyposis (HP:0100582)1.61694191
147Abnormality of the thoracic spine (HP:0100711)1.60411781
148Supernumerary nipples (HP:0002558)1.57923496
149Rigidity (HP:0002063)1.56194778
150Arterial tortuosity (HP:0005116)1.55228255
151Orchitis (HP:0100796)1.54594073
152Partial duplication of thumb phalanx (HP:0009944)1.53839056
153Personality changes (HP:0000751)1.52348109

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.96072304
2RIPK43.10524522
3NTRK32.74793474
4CAMKK12.60291331
5KSR22.59461500
6IRAK32.54088438
7EEF2K2.52722755
8MINK12.50210124
9TRIB32.34662897
10PAK62.31133962
11MARK12.22004581
12DAPK22.13978930
13SIK22.07434531
14ICK1.99597419
15SMG11.93486494
16FES1.91045611
17MAP3K41.90249408
18RIPK11.89010965
19MAP3K121.86217828
20SCYL21.75850334
21EPHA41.75627667
22CAMKK21.73760557
23TAOK11.68674385
24SIK11.62016323
25NTRK11.60884888
26PKN21.60804314
27MAP2K41.57384963
28ALK1.52238683
29CDK121.47860443
30MAP3K21.45698343
31CAMK1D1.44110192
32MARK21.39912997
33RET1.36416420
34DAPK11.27734929
35STK381.26971393
36PRKD31.26380994
37CDC42BPA1.23106577
38TESK11.22570548
39CDK51.21719395
40MAP2K71.20208789
41MAP3K131.19100670
42FGR1.17970623
43NTRK21.17874208
44PRKCH1.12482717
45DMPK1.12283819
46TAOK21.11656583
47GRK51.08401478
48KSR11.07273567
49CDK191.06742353
50MAP3K141.06341671
51BRAF1.05741471
52PDK11.05321916
53NME21.04884547
54TYRO31.04638528
55MAP4K11.02651038
56MAP3K31.01356518
57STK110.98950586
58LATS20.98371892
59PDPK10.97898391
60PLK20.97068031
61MAP3K10.96325959
62BLK0.95414734
63FGFR40.93071285
64BMX0.90707488
65LMTK20.90448730
66TYK20.89513981
67PRKD20.88896165
68PHKG20.88793071
69PHKG10.88793071
70MOS0.87480031
71PTK2B0.87235919
72JAK10.86886050
73MATK0.86698674
74MAP2K30.83223427
75CAMK1G0.81383497
76PRKG20.77823993
77PAK40.77207292
78IRAK20.77108454
79PTK20.75295829
80CDK140.74017607
81GRK60.73518034
82HCK0.73392393
83SYK0.72715050
84PRPF4B0.72046590
85ZAP700.70644444
86ERN10.70448074
87ARAF0.69981260
88CDK150.68871956
89MAP3K110.67864423
90FYN0.66844135
91CDK180.65759604
92CAMK10.64450196
93SGK4940.64251538
94SGK2230.64251538
95CSK0.63761281
96MTOR0.63450955
97PRKCG0.62167615
98TBK10.62026556
99RAF10.61250951
100PDGFRA0.60967076
101LRRK20.60741547
102WNK10.60533601
103JAK20.59634924
104SGK30.58169587
105CDK11A0.57698923
106DDR20.56728411
107EPHB20.55787403
108HIPK20.54357611
109UHMK10.54035482
110MAP3K60.53796891
111RPS6KA20.53671462
112IRAK40.53598945
113FGFR30.52866814
114DAPK30.52537207
115MAP3K80.51454473
116SGK20.51312180
117PTK60.50532619
118PAK30.50292382
119CSNK1G20.49387854
120CAMK2A0.48666328
121YES10.47185414
122EPHB10.47171884
123ROCK20.47003116
124TTN0.46207801
125MAP3K70.45992261
126EGFR0.45749171
127TGFBR20.44229408
128KIT0.44019925
129RPS6KC10.43881226
130RPS6KL10.43881226
131MAPK120.42431629
132AKT30.42303927
133EPHA20.42144122
134MAP3K100.42135328
135PRKD10.39545692
136SRC0.39209268
137MAP3K50.38594940
138FER0.38298885
139PRKCZ0.37916248
140PDGFRB0.37366614
141SGK10.37093489

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.52631995
2Long-term potentiation_Homo sapiens_hsa047202.10012381
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08769138
4Olfactory transduction_Homo sapiens_hsa047402.00955131
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97434529
6Nicotine addiction_Homo sapiens_hsa050331.84935704
7Prion diseases_Homo sapiens_hsa050201.80707799
8Other glycan degradation_Homo sapiens_hsa005111.79398898
9Circadian entrainment_Homo sapiens_hsa047131.71678490
10Salivary secretion_Homo sapiens_hsa049701.65874479
11Gastric acid secretion_Homo sapiens_hsa049711.64152397
12Glutamatergic synapse_Homo sapiens_hsa047241.63742976
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.59706956
14Dopaminergic synapse_Homo sapiens_hsa047281.57994066
15GABAergic synapse_Homo sapiens_hsa047271.57809772
16Morphine addiction_Homo sapiens_hsa050321.54745890
17Amphetamine addiction_Homo sapiens_hsa050311.50728512
18Cholinergic synapse_Homo sapiens_hsa047251.45448712
19Glioma_Homo sapiens_hsa052141.43686568
20Long-term depression_Homo sapiens_hsa047301.41692906
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40645378
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40056323
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39199820
24GnRH signaling pathway_Homo sapiens_hsa049121.38419277
25Oxytocin signaling pathway_Homo sapiens_hsa049211.35144360
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34001362
27Renin secretion_Homo sapiens_hsa049241.32723833
28Notch signaling pathway_Homo sapiens_hsa043301.30869995
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29877281
30Acute myeloid leukemia_Homo sapiens_hsa052211.29030828
31VEGF signaling pathway_Homo sapiens_hsa043701.28242004
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23022445
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.21540384
34Estrogen signaling pathway_Homo sapiens_hsa049151.19744483
35Insulin secretion_Homo sapiens_hsa049111.19648653
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18031904
37B cell receptor signaling pathway_Homo sapiens_hsa046621.16551973
38Type II diabetes mellitus_Homo sapiens_hsa049301.15477529
39TNF signaling pathway_Homo sapiens_hsa046681.13337856
40Dorso-ventral axis formation_Homo sapiens_hsa043201.13226835
41Osteoclast differentiation_Homo sapiens_hsa043801.12385529
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11957994
43Gap junction_Homo sapiens_hsa045401.10857350
44Bladder cancer_Homo sapiens_hsa052191.09275681
45Hepatitis C_Homo sapiens_hsa051601.08572339
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07806933
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07751864
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07713555
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07584582
50Tuberculosis_Homo sapiens_hsa051521.06440693
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.05718562
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04513301
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04308096
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01297503
55Salmonella infection_Homo sapiens_hsa051321.00855839
56Chemokine signaling pathway_Homo sapiens_hsa040621.00207802
57Endocytosis_Homo sapiens_hsa041441.00061781
58Staphylococcus aureus infection_Homo sapiens_hsa051500.99619579
59ErbB signaling pathway_Homo sapiens_hsa040120.99129499
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.98167912
61Cocaine addiction_Homo sapiens_hsa050300.95168124
62Leishmaniasis_Homo sapiens_hsa051400.95055015
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.94530196
64Collecting duct acid secretion_Homo sapiens_hsa049660.93950630
65cAMP signaling pathway_Homo sapiens_hsa040240.93662353
66Calcium signaling pathway_Homo sapiens_hsa040200.93305247
67Platelet activation_Homo sapiens_hsa046110.92440366
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.91606157
69Serotonergic synapse_Homo sapiens_hsa047260.90529189
70mTOR signaling pathway_Homo sapiens_hsa041500.90432234
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87222285
72Malaria_Homo sapiens_hsa051440.86891468
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85698087
74Influenza A_Homo sapiens_hsa051640.84495089
75Non-small cell lung cancer_Homo sapiens_hsa052230.84206427
76Lysosome_Homo sapiens_hsa041420.83661781
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83254242
78Pertussis_Homo sapiens_hsa051330.81245823
79Renal cell carcinoma_Homo sapiens_hsa052110.79898876
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79894506
81Shigellosis_Homo sapiens_hsa051310.79798239
82MAPK signaling pathway_Homo sapiens_hsa040100.78773731
83Endometrial cancer_Homo sapiens_hsa052130.77313465
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.76565741
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.76381189
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76206701
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76106941
88Nitrogen metabolism_Homo sapiens_hsa009100.76060212
89Taste transduction_Homo sapiens_hsa047420.75947799
90Choline metabolism in cancer_Homo sapiens_hsa052310.75360241
91Chronic myeloid leukemia_Homo sapiens_hsa052200.74310982
92Axon guidance_Homo sapiens_hsa043600.73636762
93Prostate cancer_Homo sapiens_hsa052150.73097874
94Rap1 signaling pathway_Homo sapiens_hsa040150.72331525
95Adherens junction_Homo sapiens_hsa045200.72262543
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72070951
97Hepatitis B_Homo sapiens_hsa051610.71775945
98Bile secretion_Homo sapiens_hsa049760.71339529
99Galactose metabolism_Homo sapiens_hsa000520.71225226
100Phagosome_Homo sapiens_hsa041450.70184191
101Mineral absorption_Homo sapiens_hsa049780.68924676
102Apoptosis_Homo sapiens_hsa042100.68917473
103Melanogenesis_Homo sapiens_hsa049160.68014150
104Pancreatic cancer_Homo sapiens_hsa052120.67770333
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67241886
106African trypanosomiasis_Homo sapiens_hsa051430.66769533
107Prolactin signaling pathway_Homo sapiens_hsa049170.66612681
108Dilated cardiomyopathy_Homo sapiens_hsa054140.66605267
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66430327
110Pancreatic secretion_Homo sapiens_hsa049720.65624571
111Rheumatoid arthritis_Homo sapiens_hsa053230.65220946
112T cell receptor signaling pathway_Homo sapiens_hsa046600.64552594
113HIF-1 signaling pathway_Homo sapiens_hsa040660.64381562
114Amoebiasis_Homo sapiens_hsa051460.63159428
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.62896322
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.62775983
117Colorectal cancer_Homo sapiens_hsa052100.62408231
118Proteoglycans in cancer_Homo sapiens_hsa052050.62200693
119Thyroid cancer_Homo sapiens_hsa052160.61762903
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.61189934
121Thyroid hormone synthesis_Homo sapiens_hsa049180.60360522
122Insulin signaling pathway_Homo sapiens_hsa049100.59688081
123Focal adhesion_Homo sapiens_hsa045100.59194995
124Toxoplasmosis_Homo sapiens_hsa051450.58922154
125Vibrio cholerae infection_Homo sapiens_hsa051100.58616171
126Oocyte meiosis_Homo sapiens_hsa041140.57827804
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57604134
128Ras signaling pathway_Homo sapiens_hsa040140.56067634
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55755256
130Fructose and mannose metabolism_Homo sapiens_hsa000510.54634944
131Inositol phosphate metabolism_Homo sapiens_hsa005620.52348507
132AMPK signaling pathway_Homo sapiens_hsa041520.51704702

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