PITPNM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.24110347
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.99613623
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.74746125
4sodium ion export (GO:0071436)5.60928411
5locomotory exploration behavior (GO:0035641)5.38690672
6cellular potassium ion homeostasis (GO:0030007)5.28030868
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.04273367
8synaptic vesicle exocytosis (GO:0016079)4.94360700
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.89207537
10regulation of synaptic vesicle exocytosis (GO:2000300)4.86661857
11antigen processing and presentation of endogenous antigen (GO:0019883)4.77956307
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.68793785
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.67520585
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.59975520
15response to pheromone (GO:0019236)4.58885928
16glutamate secretion (GO:0014047)4.37897432
17positive regulation of gamma-delta T cell activation (GO:0046645)4.35804170
18vocalization behavior (GO:0071625)4.35214436
19negative regulation of erythrocyte differentiation (GO:0045647)4.26728216
20regulation of synaptic vesicle transport (GO:1902803)4.25486961
21neurotransmitter secretion (GO:0007269)4.15743056
22regulation of ARF protein signal transduction (GO:0032012)4.14923656
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.05823393
24protein localization to synapse (GO:0035418)4.02459971
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.00730697
26regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00598949
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99317774
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.99317774
29modulation by symbiont of host immune response (GO:0052553)3.99317774
30positive regulation by symbiont of host defense response (GO:0052509)3.99317774
31modulation by symbiont of host defense response (GO:0052031)3.99317774
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99317774
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.93398298
34layer formation in cerebral cortex (GO:0021819)3.87713064
35cerebellar Purkinje cell differentiation (GO:0021702)3.86330997
36exploration behavior (GO:0035640)3.83611503
37detection of bacterium (GO:0016045)3.82953504
38regulation of glutamate receptor signaling pathway (GO:1900449)3.81570661
39detection of other organism (GO:0098543)3.80083607
40potassium ion homeostasis (GO:0055075)3.77088592
41potassium ion import (GO:0010107)3.70028801
42regulation of synapse structural plasticity (GO:0051823)3.64993253
43retinal cone cell development (GO:0046549)3.64183399
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.62591910
45retinal rod cell development (GO:0046548)3.61694315
46cell communication by electrical coupling (GO:0010644)3.60084660
47tolerance induction (GO:0002507)3.56855468
48regulation of clathrin-mediated endocytosis (GO:2000369)3.55465318
49activation of protein kinase A activity (GO:0034199)3.53713775
50synaptic vesicle endocytosis (GO:0048488)3.51982805
51macrophage activation involved in immune response (GO:0002281)3.51569781
52long-term memory (GO:0007616)3.46987987
53gamma-aminobutyric acid transport (GO:0015812)3.46096789
54positive thymic T cell selection (GO:0045059)3.45278652
55regulation of gamma-delta T cell activation (GO:0046643)3.42524466
56regulation of neuronal synaptic plasticity (GO:0048168)3.42212453
57positive regulation of synapse maturation (GO:0090129)3.42081895
58detection of light stimulus involved in sensory perception (GO:0050962)3.38710864
59detection of light stimulus involved in visual perception (GO:0050908)3.38710864
60cellular sodium ion homeostasis (GO:0006883)3.38274303
61rhodopsin mediated signaling pathway (GO:0016056)3.37971038
62negative regulation of lymphocyte mediated immunity (GO:0002707)3.36121570
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35911570
64germinal center formation (GO:0002467)3.34679651
65photoreceptor cell development (GO:0042461)3.33770233
66glutamate receptor signaling pathway (GO:0007215)3.33181099
67leukocyte aggregation (GO:0070486)3.32562063
68response to muramyl dipeptide (GO:0032495)3.32377827
69synaptic transmission, glutamatergic (GO:0035249)3.31652277
70positive regulation of membrane potential (GO:0045838)3.31537966
71neurotransmitter transport (GO:0006836)3.31039837
72signal complex assembly (GO:0007172)3.30305984
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.30067523
74thymic T cell selection (GO:0045061)3.29677394
75regulation of rhodopsin mediated signaling pathway (GO:0022400)3.29058690
76negative regulation of cell killing (GO:0031342)3.27156153
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27156153
78response to peptidoglycan (GO:0032494)3.26395619
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.24014348
80mannose metabolic process (GO:0006013)3.23922658
81membrane hyperpolarization (GO:0060081)3.19800591
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19721624
83negative regulation of leukocyte mediated immunity (GO:0002704)3.19050000
84regulation of voltage-gated calcium channel activity (GO:1901385)3.18214077
85regulation of B cell receptor signaling pathway (GO:0050855)3.16749564
86regulation of neurotransmitter secretion (GO:0046928)3.15630705
87eye photoreceptor cell development (GO:0042462)3.15239649
88prepulse inhibition (GO:0060134)3.15021659
89glycine transport (GO:0015816)3.13137987
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12901140
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.12877462
92negative thymic T cell selection (GO:0045060)3.12821345
93B cell receptor signaling pathway (GO:0050853)3.11659563
94neuronal action potential propagation (GO:0019227)3.11333202
95neurotransmitter-gated ion channel clustering (GO:0072578)3.09688426
96gamma-aminobutyric acid signaling pathway (GO:0007214)3.09462844
97neuromuscular process controlling posture (GO:0050884)3.08340447
98regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07771439
99neuromuscular process controlling balance (GO:0050885)3.07705965
100regulation of gamma-delta T cell differentiation (GO:0045586)3.07467896
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06155313
102dendritic spine morphogenesis (GO:0060997)3.05746110
103T cell selection (GO:0045058)3.04622488
104negative regulation of toll-like receptor signaling pathway (GO:0034122)3.04423448
105neuron-neuron synaptic transmission (GO:0007270)3.04051413
106regulation of postsynaptic membrane potential (GO:0060078)3.03660408
107membrane depolarization during action potential (GO:0086010)3.01950741
108regulation of interferon-beta biosynthetic process (GO:0045357)3.00409066
109neutrophil activation involved in immune response (GO:0002283)2.98914511
110proline transport (GO:0015824)2.98480393
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97551418
112regulation of vesicle fusion (GO:0031338)2.97354508
113regulation of T-helper 2 cell differentiation (GO:0045628)2.96593160
114regulation of leukocyte degranulation (GO:0043300)2.95231412
115negative T cell selection (GO:0043383)2.93547979
116antigen processing and presentation via MHC class Ib (GO:0002475)2.92051936
117regulation of neurotransmitter levels (GO:0001505)2.90566597
118protein localization to endosome (GO:0036010)2.89171668
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.88907779
120positive regulation of Rap GTPase activity (GO:0032854)2.87710185
121response to laminar fluid shear stress (GO:0034616)2.87152892
122regulation of tolerance induction (GO:0002643)2.87067865
123detection of external biotic stimulus (GO:0098581)2.86749568
124regulation of neurotransmitter transport (GO:0051588)2.86278878
125mating behavior (GO:0007617)2.83610709
126positive regulation of Cdc42 GTPase activity (GO:0043089)2.82041545
127regulation of myeloid leukocyte mediated immunity (GO:0002886)2.81792269
128regulation of ARF GTPase activity (GO:0032312)2.81304864
129dendrite morphogenesis (GO:0048813)2.81259464
130long-term synaptic potentiation (GO:0060291)2.78503568
131NIK/NF-kappaB signaling (GO:0038061)2.78450809
132response to auditory stimulus (GO:0010996)2.78207611
133positive regulation of potassium ion transmembrane transport (GO:1901381)2.78032807
134axon cargo transport (GO:0008088)2.77966374
135positive regulation of neurotransmitter transport (GO:0051590)2.77455867
136innervation (GO:0060384)2.77329506
137vesicle transport along microtubule (GO:0047496)2.76860967
138positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76742183
139response to interleukin-15 (GO:0070672)2.76042505
140negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.75836954
141membrane repolarization (GO:0086009)2.75065003
142activation of Rac GTPase activity (GO:0032863)2.74967277
143positive T cell selection (GO:0043368)2.72164077
144regulation of regulated secretory pathway (GO:1903305)2.72090074
145regulation of synaptic plasticity (GO:0048167)2.71667813
146positive regulation of vesicle fusion (GO:0031340)2.71160914
147positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.70921124
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.70556341
149immunoglobulin mediated immune response (GO:0016064)2.70176464
150membrane depolarization (GO:0051899)2.69122005
151regulation of mast cell degranulation (GO:0043304)2.68581211
152regulation of calcium ion-dependent exocytosis (GO:0017158)2.64982895
153dopamine receptor signaling pathway (GO:0007212)2.64120775
154auditory behavior (GO:0031223)2.63285287
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.63148585
156L-amino acid import (GO:0043092)2.62502918
157hypotonic response (GO:0006971)2.61774191
158regulation of defense response to virus by virus (GO:0050690)2.61433650
159response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59359005
160response to host (GO:0075136)2.59359005
161response to host defenses (GO:0052200)2.59359005
162response to type I interferon (GO:0034340)2.59326986
163peptidyl-tyrosine autophosphorylation (GO:0038083)2.59097092
164photoreceptor cell maintenance (GO:0045494)2.58638908
165positive regulation of tolerance induction (GO:0002645)2.57951680
166type I interferon signaling pathway (GO:0060337)2.57951348
167cellular response to type I interferon (GO:0071357)2.57951348
168negative regulation of T cell mediated immunity (GO:0002710)2.56861334
169response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.56070546
170response to host immune response (GO:0052572)2.56070546
171cellular extravasation (GO:0045123)2.55387223
172respiratory burst (GO:0045730)2.54939998
173regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53804980
174regulation of T cell tolerance induction (GO:0002664)2.51152796
175detection of biotic stimulus (GO:0009595)2.50828928
176modulation by symbiont of host cellular process (GO:0044068)2.50291554
177interferon-gamma-mediated signaling pathway (GO:0060333)2.47445823
178modulation by virus of host process (GO:0019054)2.46372991
179negative regulation of interleukin-12 production (GO:0032695)2.44829663
180regulation of extracellular matrix disassembly (GO:0010715)2.43952343
181negative regulation of type 2 immune response (GO:0002829)2.43157062
182negative regulation of glycoprotein biosynthetic process (GO:0010561)2.40794812
183positive regulation of protein dephosphorylation (GO:0035307)2.40352676
184myeloid cell activation involved in immune response (GO:0002275)2.37314577
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.35490962
186positive regulation of type 2 immune response (GO:0002830)2.35475765
187regulation of mast cell activation involved in immune response (GO:0033006)2.34288582
188positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.32892545
189regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.32276611
190regulation of Rap GTPase activity (GO:0032317)2.31901869
191cellular response to interleukin-15 (GO:0071350)2.30696455
192regulation of type I interferon-mediated signaling pathway (GO:0060338)2.29407087
193regulation of natural killer cell mediated immunity (GO:0002715)2.28347630
194regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.28347630
195negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.27927425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.76469836
2DROSHA_22980978_ChIP-Seq_HELA_Human3.12048101
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.98748743
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.79106646
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.53130352
6REST_21632747_ChIP-Seq_MESCs_Mouse2.46754589
7* IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41260680
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.35814440
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32001863
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.30064955
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29387015
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.27350619
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25201607
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24000214
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17407443
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.14688785
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13561096
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13438522
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13438522
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12904049
21VDR_24763502_ChIP-Seq_THP-1_Human2.10901318
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.08472436
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.04770430
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04074963
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01912960
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.99455777
27* MAF_26560356_Chip-Seq_TH1_Human1.98996905
28RACK7_27058665_Chip-Seq_MCF-7_Human1.95032129
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92907344
30* KDM2B_26808549_Chip-Seq_K562_Human1.92570173
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.88744228
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86291772
33* KDM2B_26808549_Chip-Seq_DND41_Human1.85794321
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.81691071
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80245004
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79917454
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.78372280
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.77996543
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75549149
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.75358162
41* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74964166
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73135341
43* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71024188
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68136354
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67911897
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66515796
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60935456
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59936441
49* KDM2B_26808549_Chip-Seq_JURKAT_Human1.59402252
50GBX2_23144817_ChIP-Seq_PC3_Human1.59015271
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58976944
52MAF_26560356_Chip-Seq_TH2_Human1.55805354
53LXR_22292898_ChIP-Seq_THP-1_Human1.53927835
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51441317
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48258363
56RUNX_20019798_ChIP-Seq_JUKART_Human1.48195460
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48163940
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.47897466
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.47264890
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.47070415
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.45159475
62* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44728534
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.43911943
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42309685
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.42019714
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39549794
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39158641
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38255875
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38004995
70BCOR_27268052_Chip-Seq_Bcells_Human1.37700204
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37168710
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37147333
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36829757
74AR_21572438_ChIP-Seq_LNCaP_Human1.36308362
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35744857
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34937629
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.34086094
78MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33895697
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32605484
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.31387881
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30859567
82* TCF7_22412390_ChIP-Seq_EML_Mouse1.30858496
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.30290734
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.29987518
85* TET1_21451524_ChIP-Seq_MESCs_Mouse1.29689865
86MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28680844
87MYC_22102868_ChIP-Seq_BL_Human1.28224881
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27577179
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26728820
90SMC4_20622854_ChIP-Seq_HELA_Human1.25918309
91BCL6_27268052_Chip-Seq_Bcells_Human1.25549143
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23659675
93AR_19668381_ChIP-Seq_PC3_Human1.23611629
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22309007
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.22092215
96* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21892491
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20452143
98* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20158403
99STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20081121
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19074633
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18845360
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.16979144
103SPI1_23127762_ChIP-Seq_K562_Human1.15894402
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15521723
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15492838
106SCL_19346495_ChIP-Seq_HPC-7_Human1.14607446
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13850593
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13103147
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12873907
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12670227
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12064841
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11812071
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.11752820
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11426319
115CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10419011
116* NCOR1_26117541_ChIP-Seq_K562_Human1.09579943
117* SPI1_23547873_ChIP-Seq_NB4_Human1.08973773
118STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08397916
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06995219
120* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06620813
121PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05861268
122MYB_26560356_Chip-Seq_TH1_Human1.04748414
123* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04164040
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03685412
125* TP63_22573176_ChIP-Seq_HFKS_Human1.03538474
126P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03208142
127NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98773777
128* CTCF_27219007_Chip-Seq_Bcells_Human0.98724864
129FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98609121
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.98600729
131RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97283914
132SMAD4_21799915_ChIP-Seq_A2780_Human0.96439094
133* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96018991
134P68_20966046_ChIP-Seq_HELA_Human0.95662084
135CREB1_26743006_Chip-Seq_LNCaP_Human0.95606987
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94763067
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.93412501
138GATA1_19941826_ChIP-Seq_K562_Human0.92198274
139OCT4_19829295_ChIP-Seq_ESCs_Human0.91269413
140RING1B_27294783_Chip-Seq_NPCs_Mouse0.87612557
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.86147239
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85561906
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.85398218
144* UTX_26944678_Chip-Seq_JUKART_Human0.85366857
145SMAD4_21741376_ChIP-Seq_ESCs_Human0.84886642
146CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84380907
147KLF4_19829295_ChIP-Seq_ESCs_Human0.84130350
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84094485
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83626618
150NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83473074
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83462916
152* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83182312
153SMAD3_21741376_ChIP-Seq_ESCs_Human0.82823752
154VDR_21846776_ChIP-Seq_THP-1_Human0.81958789
155ELK4_26923725_Chip-Seq_MESODERM_Mouse0.81696125
156EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81033581
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80537213
158STAT3_23295773_ChIP-Seq_U87_Human0.80406420
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79409141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.84931549
2MP0005551_abnormal_eye_electrophysiolog4.04600018
3MP0003436_decreased_susceptibility_to3.87512324
4MP0003635_abnormal_synaptic_transmissio3.64664964
5MP0005423_abnormal_somatic_nervous3.31380906
6MP0009046_muscle_twitch2.95515379
7MP0003880_abnormal_central_pattern2.92002787
8MP0006072_abnormal_retinal_apoptosis2.79813260
9MP0002064_seizures2.77192371
10MP0009745_abnormal_behavioral_response2.74830532
11MP0001835_abnormal_antigen_presentation2.67864223
12MP0004270_analgesia2.67396683
13MP0002063_abnormal_learning/memory/cond2.64091783
14MP0005253_abnormal_eye_physiology2.48890441
15MP0003724_increased_susceptibility_to2.43859696
16MP0000685_abnormal_immune_system2.43142326
17MP0008569_lethality_at_weaning2.42949122
18MP0008260_abnormal_autophagy2.39678822
19MP0003705_abnormal_hypodermis_morpholog2.34646662
20MP0003011_delayed_dark_adaptation2.31572193
21MP0002419_abnormal_innate_immunity2.30233114
22MP0005451_abnormal_body_composition2.28963633
23MP0001968_abnormal_touch/_nociception2.25996962
24MP0002272_abnormal_nervous_system2.24624387
25MP0001800_abnormal_humoral_immune2.23114153
26MP0005000_abnormal_immune_tolerance2.22687613
27MP0005025_abnormal_response_to2.22676676
28MP0009278_abnormal_bone_marrow2.16934639
29MP0004947_skin_inflammation2.11004167
30MP0002572_abnormal_emotion/affect_behav2.09271339
31MP0002734_abnormal_mechanical_nocicepti2.06671140
32MP0002090_abnormal_vision2.06262255
33MP0001486_abnormal_startle_reflex2.05872768
34MP0002822_catalepsy2.04110500
35MP0002909_abnormal_adrenal_gland2.01736977
36MP0005671_abnormal_response_to2.01333991
37MP0010155_abnormal_intestine_physiology2.00960874
38MP0001502_abnormal_circadian_rhythm2.00343532
39MP0005058_abnormal_lysosome_morphology2.00283129
40MP0001849_ear_inflammation1.98729058
41MP0001501_abnormal_sleep_pattern1.95267489
42MP0002420_abnormal_adaptive_immunity1.94415028
43MP0002452_abnormal_antigen_presenting1.92809208
44MP0001819_abnormal_immune_cell1.92718365
45MP0002723_abnormal_immune_serum1.91944332
46MP0008961_abnormal_basal_metabolism1.90946154
47MP0003191_abnormal_cellular_cholesterol1.87638272
48MP0003329_amyloid_beta_deposits1.85109582
49MP0000569_abnormal_digit_pigmentation1.77967007
50MP0009780_abnormal_chondrocyte_physiolo1.74818429
51MP0006082_CNS_inflammation1.74282325
52MP0001533_abnormal_skeleton_physiology1.70833103
53MP0002229_neurodegeneration1.70193347
54MP0002067_abnormal_sensory_capabilities1.69531313
55MP0001348_abnormal_lacrimal_gland1.66057864
56MP0004510_myositis1.63895719
57MP0004811_abnormal_neuron_physiology1.61954275
58MP0005076_abnormal_cell_differentiation1.58917520
59MP0009785_altered_susceptibility_to1.58876303
60MP0001970_abnormal_pain_threshold1.54133440
61MP0002405_respiratory_system_inflammati1.53907711
62MP0001984_abnormal_olfaction1.53226167
63MP0003172_abnormal_lysosome_physiology1.53128026
64MP0002184_abnormal_innervation1.52024036
65MP0004858_abnormal_nervous_system1.50978579
66MP0005464_abnormal_platelet_physiology1.50282783
67MP0004885_abnormal_endolymph1.50176912
68MP0009333_abnormal_splenocyte_physiolog1.48743544
69MP0002882_abnormal_neuron_morphology1.48585889
70MP0003633_abnormal_nervous_system1.48585542
71MP0001440_abnormal_grooming_behavior1.47925398
72MP0003787_abnormal_imprinting1.47381304
73MP0002132_abnormal_respiratory_system1.46684565
74MP0002736_abnormal_nociception_after1.45529782
75MP0002398_abnormal_bone_marrow1.45107728
76MP0005195_abnormal_posterior_eye1.44882305
77MP0000858_altered_metastatic_potential1.44432369
78MP0000716_abnormal_immune_system1.44105789
79MP0003091_abnormal_cell_migration1.42968515
80MP0003453_abnormal_keratinocyte_physiol1.41023875
81MP0003303_peritoneal_inflammation1.40650860
82MP0002733_abnormal_thermal_nociception1.38720889
83MP0005409_darkened_coat_color1.38595874
84MP0005310_abnormal_salivary_gland1.37584404
85MP0002638_abnormal_pupillary_reflex1.35729294
86MP0002735_abnormal_chemical_nociception1.34790930
87MP0002998_abnormal_bone_remodeling1.34669041
88MP0004924_abnormal_behavior1.34061873
89MP0005386_behavior/neurological_phenoty1.34061873
90MP0009840_abnormal_foam_cell1.33002210
91MP0002148_abnormal_hypersensitivity_rea1.31877570
92MP0003879_abnormal_hair_cell1.31493324
93MP0002557_abnormal_social/conspecific_i1.30479341
94MP0003566_abnormal_cell_adhesion1.30066417
95MP0001845_abnormal_inflammatory_respons1.29913673
96MP0001873_stomach_inflammation1.29069570
97MP0003045_fibrosis1.22481664
98MP0000955_abnormal_spinal_cord1.19854403
99MP0001851_eye_inflammation1.19708864
100MP0003075_altered_response_to1.18633266
101MP0003828_pulmonary_edema1.16139557
102MP0000465_gastrointestinal_hemorrhage1.13585903
103MP0002066_abnormal_motor_capabilities/c1.13454060
104MP0000703_abnormal_thymus_morphology1.13375447
105MP0002429_abnormal_blood_cell1.12067150
106MP0000678_abnormal_parathyroid_gland1.12047698
107MP0000013_abnormal_adipose_tissue1.11987994
108MP0002722_abnormal_immune_system1.11663897
109MP0000604_amyloidosis1.07932822
110MP0003631_nervous_system_phenotype1.07511202
111MP0000490_abnormal_crypts_of1.07277386
112MP0004381_abnormal_hair_follicle1.05903671
113MP0002396_abnormal_hematopoietic_system1.00319757
114MP0004233_abnormal_muscle_weight1.00116486
115MP0005645_abnormal_hypothalamus_physiol1.00014387
116MP0000689_abnormal_spleen_morphology0.99649217
117MP0005394_taste/olfaction_phenotype0.98548869
118MP0005499_abnormal_olfactory_system0.98548869
119MP0002752_abnormal_somatic_nervous0.98492015
120MP0001324_abnormal_eye_pigmentation0.97715944
121MP0003634_abnormal_glial_cell0.97635445
122MP0004145_abnormal_muscle_electrophysio0.96904218
123MP0003300_gastrointestinal_ulcer0.95771242
124MP0008469_abnormal_protein_level0.93797131
125MP0004264_abnormal_extraembryonic_tissu0.90269269
126MP0001958_emphysema0.88981067
127MP0005646_abnormal_pituitary_gland0.88940791
128MP0005391_vision/eye_phenotype0.88911250
129MP0000778_abnormal_nervous_system0.88313744
130MP0002152_abnormal_brain_morphology0.86521828
131MP0008874_decreased_physiological_sensi0.86424732
132MP0008872_abnormal_physiological_respon0.86370755
133MP0003866_abnormal_defecation0.86235918
134MP0000751_myopathy0.84304395
135MP0003690_abnormal_glial_cell0.84272531
136MP0002653_abnormal_ependyma_morphology0.83859037
137MP0002089_abnormal_postnatal_growth/wei0.81740122
138MP0003283_abnormal_digestive_organ0.81575765
139MP0004142_abnormal_muscle_tone0.81187995
140MP0002069_abnormal_eating/drinking_beha0.80301748
141MP0002933_joint_inflammation0.80234699
142MP0001663_abnormal_digestive_system0.79876785
143MP0001545_abnormal_hematopoietic_system0.78925621
144MP0005397_hematopoietic_system_phenotyp0.78925621
145MP0005390_skeleton_phenotype0.78159752
146MP0004742_abnormal_vestibular_system0.72842491
147MP0005535_abnormal_body_temperature0.72327508
148MP0001765_abnormal_ion_homeostasis0.72298639
149MP0002166_altered_tumor_susceptibility0.71154202
150MP0003183_abnormal_peptide_metabolism0.69381126
151MP0005377_hearing/vestibular/ear_phenot0.68545828
152MP0003878_abnormal_ear_physiology0.68545828
153MP0000920_abnormal_myelination0.66457176
154MP0003632_abnormal_nervous_system0.66346018
155MP0005666_abnormal_adipose_tissue0.66206733
156MP0004185_abnormal_adipocyte_glucose0.66179693
157MP0005023_abnormal_wound_healing0.65747767
158MP0003448_altered_tumor_morphology0.65341120
159MP0004808_abnormal_hematopoietic_stem0.64134016
160MP0005167_abnormal_blood-brain_barrier0.63006854
161MP0000003_abnormal_adipose_tissue0.62475399
162MP0004130_abnormal_muscle_cell0.61007902
163MP0002877_abnormal_melanocyte_morpholog0.60395433
164MP0003795_abnormal_bone_structure0.58841612
165MP0000249_abnormal_blood_vessel0.58244776
166MP0005166_decreased_susceptibility_to0.58214493
167MP0001986_abnormal_taste_sensitivity0.58189625
168MP0004085_abnormal_heartbeat0.57791460
169MP0010386_abnormal_urinary_bladder0.57066205
170MP0001177_atelectasis0.55758027
171MP0003763_abnormal_thymus_physiology0.54228885
172MP0010234_abnormal_vibrissa_follicle0.53432726
173MP0004215_abnormal_myocardial_fiber0.53171589
174MP0003122_maternal_imprinting0.52763576
175MP0005387_immune_system_phenotype0.52122525
176MP0001790_abnormal_immune_system0.52122525

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.16257929
2Central scotoma (HP:0000603)5.68749746
3Abnormal rod and cone electroretinograms (HP:0008323)5.52214042
4Absent rod-and cone-mediated responses on ERG (HP:0007688)5.27839718
5Bony spicule pigmentary retinopathy (HP:0007737)4.99247309
6Eczematoid dermatitis (HP:0000976)4.92583644
7Visual hallucinations (HP:0002367)4.91953847
8Scotoma (HP:0000575)4.31328837
9Abnormality of macular pigmentation (HP:0008002)4.29972124
10Focal motor seizures (HP:0011153)4.19917454
11Myokymia (HP:0002411)4.17389604
12Focal seizures (HP:0007359)4.06037346
13Obstructive sleep apnea (HP:0002870)4.01075225
14Severe visual impairment (HP:0001141)3.90884889
15Nasal polyposis (HP:0100582)3.71415839
16Action tremor (HP:0002345)3.64659607
17Pendular nystagmus (HP:0012043)3.61267430
18Progressive cerebellar ataxia (HP:0002073)3.56258207
19Recurrent abscess formation (HP:0002722)3.56104044
20Abnormality of macrophages (HP:0004311)3.55210404
21Recurrent bacterial skin infections (HP:0005406)3.55044696
22Decreased central vision (HP:0007663)3.51163063
23Abolished electroretinogram (ERG) (HP:0000550)3.50884181
24Pigmentary retinal degeneration (HP:0001146)3.39085647
25Abnormality of the nasal mucosa (HP:0000433)3.32809587
26Supranuclear gaze palsy (HP:0000605)3.32803679
27Hemiplegia (HP:0002301)3.32682795
28Epileptic encephalopathy (HP:0200134)3.30087106
29Febrile seizures (HP:0002373)3.28890258
30Chorioretinal atrophy (HP:0000533)3.27946444
31Myositis (HP:0100614)3.19100963
32Absence seizures (HP:0002121)3.02667062
33Cellulitis (HP:0100658)3.00053005
34Depression (HP:0000716)2.99024458
35Increased IgE level (HP:0003212)2.98164125
36Dysmetric saccades (HP:0000641)2.90762162
37Posterior subcapsular cataract (HP:0007787)2.88408713
38Truncal ataxia (HP:0002078)2.82484104
39Broad face (HP:0000283)2.80728899
40Genetic anticipation (HP:0003743)2.78118409
41Gingivitis (HP:0000230)2.77797805
42Dysdiadochokinesis (HP:0002075)2.77277465
43Dyschromatopsia (HP:0007641)2.77268258
44Attenuation of retinal blood vessels (HP:0007843)2.76262565
45Type II diabetes mellitus (HP:0005978)2.76071555
46Impaired smooth pursuit (HP:0007772)2.74040538
47Orchitis (HP:0100796)2.73566216
48Recurrent gram-negative bacterial infections (HP:0005420)2.73515678
49Macular degeneration (HP:0000608)2.73348358
50Abnormality of the lower motor neuron (HP:0002366)2.73045222
51Mutism (HP:0002300)2.67494303
52Flat acetabular roof (HP:0003180)2.63169595
53Atonic seizures (HP:0010819)2.63004245
54Postural instability (HP:0002172)2.62559253
55Mediastinal lymphadenopathy (HP:0100721)2.58582815
56Ankle clonus (HP:0011448)2.57939361
57Dialeptic seizures (HP:0011146)2.57131986
58Stridor (HP:0010307)2.56430741
59Colitis (HP:0002583)2.55926919
60Meningitis (HP:0001287)2.55672523
61Chronic obstructive pulmonary disease (HP:0006510)2.53025563
62Obstructive lung disease (HP:0006536)2.53025563
63Abnormality of binocular vision (HP:0011514)2.52737820
64Diplopia (HP:0000651)2.52737820
65Abnormality of ocular smooth pursuit (HP:0000617)2.52625408
66Photophobia (HP:0000613)2.52526634
67Recurrent fungal infections (HP:0002841)2.52517995
68Gastrointestinal inflammation (HP:0004386)2.52393655
69Elevated erythrocyte sedimentation rate (HP:0003565)2.52141434
70Gaze-evoked nystagmus (HP:0000640)2.49908549
71Distal lower limb muscle weakness (HP:0009053)2.45710373
72Insomnia (HP:0100785)2.45239374
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44110501
74Gastrointestinal infarctions (HP:0005244)2.43949418
75Recurrent sinusitis (HP:0011108)2.43042970
76Increased corneal curvature (HP:0100692)2.42424393
77Keratoconus (HP:0000563)2.42424393
78Papilledema (HP:0001085)2.41789334
79Hemiparesis (HP:0001269)2.41762649
80Hyperacusis (HP:0010780)2.40691297
81Ventricular fibrillation (HP:0001663)2.40405383
82Pustule (HP:0200039)2.40380815
83Inflammation of the large intestine (HP:0002037)2.40316884
84Urinary bladder sphincter dysfunction (HP:0002839)2.40061740
85Generalized tonic-clonic seizures (HP:0002069)2.37787068
86Abnormal social behavior (HP:0012433)2.34403174
87Impaired social interactions (HP:0000735)2.34403174
88Dysmetria (HP:0001310)2.32680340
89Retrobulbar optic neuritis (HP:0100654)2.30842768
90Optic neuritis (HP:0100653)2.30842768
91Hemorrhage of the eye (HP:0011885)2.30454859
92Constricted visual fields (HP:0001133)2.29533529
93Interstitial pulmonary disease (HP:0006530)2.28413831
94Pointed chin (HP:0000307)2.26866685
95Macroorchidism (HP:0000053)2.26340126
96Poor eye contact (HP:0000817)2.25228520
97Gastrointestinal stroma tumor (HP:0100723)2.24743736
98Recurrent skin infections (HP:0001581)2.22133671
99Annular pancreas (HP:0001734)2.22100498
100Intention tremor (HP:0002080)2.20715479
101Recurrent otitis media (HP:0000403)2.20065266
102Malnutrition (HP:0004395)2.18677149
103Cone-rod dystrophy (HP:0000548)2.16754507
104Vasculitis (HP:0002633)2.14419934
105Abnormal eating behavior (HP:0100738)2.13157111
106Impaired vibration sensation in the lower limbs (HP:0002166)2.11396896
107Choroideremia (HP:0001139)2.10578575
108Polygenic inheritance (HP:0010982)2.09653504
109Dysostosis multiplex (HP:0000943)2.08948012
110Broad-based gait (HP:0002136)2.08774664
111Anxiety (HP:0000739)2.07555761
112Scanning speech (HP:0002168)2.07321770
113Abnormal vertebral ossification (HP:0100569)2.06643999
114Spontaneous hematomas (HP:0007420)2.06401093
115Cerebral aneurysm (HP:0004944)2.04351827
116Abnormal delayed hypersensitivity skin test (HP:0002963)2.03399674
117Dynein arm defect of respiratory motile cilia (HP:0012255)2.02279290
118Absent/shortened dynein arms (HP:0200106)2.02279290
119Urinary urgency (HP:0000012)2.00890678
120Emphysema (HP:0002097)1.98317901
121Recurrent viral infections (HP:0004429)1.97942685
122Slow saccadic eye movements (HP:0000514)1.97859294
123Chest pain (HP:0100749)1.97420977
124Stomatitis (HP:0010280)1.97142023
125Neoplasm of the heart (HP:0100544)1.96542092
126Spastic gait (HP:0002064)1.96463129
127Bradykinesia (HP:0002067)1.96019606
128Premature loss of primary teeth (HP:0006323)1.95978425
129Loss of speech (HP:0002371)1.94739372
130Bronchiectasis (HP:0002110)1.94481623
131Amyloidosis (HP:0011034)1.94360729
132Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93585416
133Abnormal respiratory motile cilium morphology (HP:0005938)1.93547065
134Abnormal respiratory epithelium morphology (HP:0012253)1.93547065
135Agammaglobulinemia (HP:0004432)1.93304864
136Recurrent cutaneous fungal infections (HP:0011370)1.93288728
137Chronic mucocutaneous candidiasis (HP:0002728)1.93288728
138Thin bony cortex (HP:0002753)1.93184379
139Chronic otitis media (HP:0000389)1.93096000
140Urticaria (HP:0001025)1.92094271
141Progressive visual loss (HP:0000529)1.91905857
142Hand muscle atrophy (HP:0009130)1.91060205
143Spinal canal stenosis (HP:0003416)1.90203931
144Upper limb amyotrophy (HP:0009129)1.88558804
145Distal upper limb amyotrophy (HP:0007149)1.88558804
146Osteomyelitis (HP:0002754)1.87191811
147Abnormal respiratory motile cilium physiology (HP:0012261)1.86297095
148Metaphyseal cupping (HP:0003021)1.85596438
149Stereotypic behavior (HP:0000733)1.84386852
150Prolonged bleeding time (HP:0003010)1.84251457
151Torticollis (HP:0000473)1.83487779
152Segmental peripheral demyelination/remyelination (HP:0003481)1.83433341
153Neurofibrillary tangles (HP:0002185)1.83097022
154Increased cerebral lipofuscin (HP:0011813)1.82718625
155Distal lower limb amyotrophy (HP:0008944)1.81747780
156Abnormality of saccadic eye movements (HP:0000570)1.81527294
157Neuronal loss in central nervous system (HP:0002529)1.80049518
158Abnormality of the distal phalanges of the toes (HP:0010182)1.79538188
159Status epilepticus (HP:0002133)1.78377640
160Mucopolysacchariduria (HP:0008155)1.78283237
161Urinary glycosaminoglycan excretion (HP:0003541)1.78283237
162Elfin facies (HP:0004428)1.77948922
163Abnormal ciliary motility (HP:0012262)1.77802424
164Subcapsular cataract (HP:0000523)1.77761704
165Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77600379
166Restrictive lung disease (HP:0002091)1.76401385
167Abnormality of polysaccharide metabolism (HP:0011012)1.76330099
168Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76330099
169Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76330099
170Hypercortisolism (HP:0001578)1.74518897
171Agitation (HP:0000713)1.74438075
172Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74123294
173Growth hormone excess (HP:0000845)1.73023962
174Retinitis pigmentosa (HP:0000510)1.72664980
175Atelectasis (HP:0100750)1.72649522
176Abnormality of the fingertips (HP:0001211)1.72098158
177Pulmonary infiltrates (HP:0002113)1.71915884
178Decreased electroretinogram (ERG) amplitude (HP:0000654)1.70429279
179Recurrent bronchitis (HP:0002837)1.68694833
180Tetraplegia (HP:0002445)1.68590618
181Cerebral inclusion bodies (HP:0100314)1.67831006
182Encephalitis (HP:0002383)1.67725726
183Apathy (HP:0000741)1.65925291
184Lymphopenia (HP:0001888)1.65753284
185Hypoventilation (HP:0002791)1.65192731
186Bundle branch block (HP:0011710)1.65097207
187Horizontal nystagmus (HP:0000666)1.64153842
188Prolonged QT interval (HP:0001657)1.63932880
189Lower limb asymmetry (HP:0100559)1.63487620
190Amyotrophic lateral sclerosis (HP:0007354)1.62780414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.56090861
2ERN13.11216689
3NTRK32.94345941
4PAK62.77778012
5SIK22.53789268
6SMG12.48229371
7CAMKK12.39092874
8RIPK12.27893575
9STK382.17152234
10SIK12.16436732
11MINK12.11838573
12MARK12.08988794
13MAP3K132.06283913
14DAPK22.04888234
15PRKD32.04622383
16EPHB12.00283517
17NTRK21.98169142
18MAP3K41.95515265
19KSR21.92002586
20PRKCH1.91563324
21EPHA41.80472418
22MAP2K31.74217628
23RIPK41.70884872
24FES1.68945038
25IRAK41.67384932
26TRIB31.64201239
27FGFR41.62977594
28BLK1.62105409
29TAOK11.59401443
30EPHA21.55545319
31CSK1.54364998
32MAP3K31.45134632
33ZAP701.43626776
34MAP3K111.43037253
35ALK1.41415929
36CAMKK21.39421083
37MAP4K11.38229956
38CAMK1G1.36243892
39TNK21.35544209
40PKN21.33804606
41CDK51.32937281
42MAP3K71.32699953
43PRPF4B1.28912342
44MST1R1.26923857
45SIK31.24368860
46TYRO31.19819908
47MAP3K101.19800033
48IRAK31.19363959
49MAP3K141.18263898
50NTRK11.15907469
51CDK121.15731234
52JAK11.15353317
53SGK31.14467291
54BTK1.13594640
55TBK11.13101172
56MAP2K41.10296649
57STK111.10293058
58MAP2K71.07201996
59MARK21.06693259
60RET1.06491545
61MAPK151.05411627
62CAMK11.03976219
63JAK31.02633030
64KSR11.01645409
65TTN0.99501886
66PDK10.93442391
67SCYL20.91117731
68EEF2K0.90701845
69SGK4940.88872832
70SGK2230.88872832
71GRK10.88466834
72ARAF0.87662754
73DAPK10.86108140
74TAOK20.86000988
75WNK10.85160284
76GRK50.84716463
77MAP3K20.83293845
78CDC42BPA0.82273123
79CSF1R0.81868835
80HIPK20.80947709
81PHKG20.80467100
82PHKG10.80467100
83PRKD20.80246262
84UHMK10.80110974
85SGK20.79928282
86CAMK1D0.79313763
87FGR0.77675710
88PINK10.77604344
89PRKCG0.76967342
90LMTK20.75432804
91DYRK1A0.74236094
92MAP3K10.71674607
93PTK60.71300200
94MAP3K120.71205805
95DMPK0.70175034
96CDK150.69570521
97FYN0.66880496
98NEK10.66401444
99CDK180.65831268
100PDPK10.65799970
101SGK10.65749542
102TESK20.65688440
103CAMK40.64756355
104LCK0.62919100
105RAF10.62425034
106ITK0.61899466
107MAP3K60.61738606
108CDK11A0.61585575
109HCK0.61349376
110JAK20.61004879
111TESK10.60880728
112BMX0.59545949
113PRKG20.59266569
114LYN0.58265181
115RPS6KC10.57501334
116RPS6KL10.57501334
117RPS6KA30.57430462
118PAK30.56907057
119EPHA30.56747167
120ICK0.55754361
121CDK140.55439248
122MAP2K20.55110138
123FGFR30.54498557
124MAPK120.53773952
125RPS6KA20.53052616
126MAPK110.52884347
127MAPK70.51119453
128MAPK100.50961060
129SYK0.50960525
130LRRK20.50726736
131DYRK1B0.50611478
132CDK190.50313233
133MTOR0.49095129
134IKBKE0.48540860
135PRKCZ0.46813768
136PAK40.46543465
137MAP3K80.46507449
138GRK60.45311507
139TYK20.44303861
140IRAK20.42449232
141PRKCB0.42222559
142TXK0.41889032
143PDGFRA0.40174909
144MAPK80.40011754
145RPS6KA60.38762417
146IRAK10.38568687
147STK100.38160209

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.66023601
2Synaptic vesicle cycle_Homo sapiens_hsa047212.92205189
3Nicotine addiction_Homo sapiens_hsa050332.73854458
4GABAergic synapse_Homo sapiens_hsa047272.40706542
5Olfactory transduction_Homo sapiens_hsa047402.38768919
6Circadian entrainment_Homo sapiens_hsa047132.21584108
7Morphine addiction_Homo sapiens_hsa050322.20698476
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16245276
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15069736
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14041153
11Glutamatergic synapse_Homo sapiens_hsa047242.04892615
12Long-term potentiation_Homo sapiens_hsa047201.93023716
13Leishmaniasis_Homo sapiens_hsa051401.88462212
14Salivary secretion_Homo sapiens_hsa049701.81740614
15Other glycan degradation_Homo sapiens_hsa005111.81637746
16Insulin secretion_Homo sapiens_hsa049111.76769383
17Cholinergic synapse_Homo sapiens_hsa047251.76337266
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71134617
19Dopaminergic synapse_Homo sapiens_hsa047281.62863281
20Gastric acid secretion_Homo sapiens_hsa049711.60556605
21Allograft rejection_Homo sapiens_hsa053301.52332358
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50577276
23Amphetamine addiction_Homo sapiens_hsa050311.49035220
24Type II diabetes mellitus_Homo sapiens_hsa049301.47547270
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46775916
26Oxytocin signaling pathway_Homo sapiens_hsa049211.45689462
27Autoimmune thyroid disease_Homo sapiens_hsa053201.42589518
28Graft-versus-host disease_Homo sapiens_hsa053321.42201365
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.41940937
30Tuberculosis_Homo sapiens_hsa051521.39760528
31Renin secretion_Homo sapiens_hsa049241.39726278
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38982471
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38708394
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34212595
35Toxoplasmosis_Homo sapiens_hsa051451.33138971
36Notch signaling pathway_Homo sapiens_hsa043301.30686523
37Staphylococcus aureus infection_Homo sapiens_hsa051501.26119321
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.25422201
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25227471
40GnRH signaling pathway_Homo sapiens_hsa049121.22932967
41Long-term depression_Homo sapiens_hsa047301.19986335
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19955614
43Viral myocarditis_Homo sapiens_hsa054161.19530664
44Cocaine addiction_Homo sapiens_hsa050301.18282513
45Taste transduction_Homo sapiens_hsa047421.15322339
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15035883
47cAMP signaling pathway_Homo sapiens_hsa040241.14609862
48Calcium signaling pathway_Homo sapiens_hsa040201.10714229
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10601022
50Influenza A_Homo sapiens_hsa051641.10033169
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07765684
52Pancreatic cancer_Homo sapiens_hsa052121.06146688
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05274964
54Estrogen signaling pathway_Homo sapiens_hsa049151.04966899
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.04034460
56Hepatitis C_Homo sapiens_hsa051601.03231316
57Serotonergic synapse_Homo sapiens_hsa047261.02398999
58Glioma_Homo sapiens_hsa052141.01876782
59TNF signaling pathway_Homo sapiens_hsa046681.00252034
60Gap junction_Homo sapiens_hsa045400.99843616
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99570541
62Nitrogen metabolism_Homo sapiens_hsa009100.98020303
63mTOR signaling pathway_Homo sapiens_hsa041500.96625802
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.96415764
65Measles_Homo sapiens_hsa051620.95835425
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.93553738
67Antigen processing and presentation_Homo sapiens_hsa046120.92268414
68Hepatitis B_Homo sapiens_hsa051610.91147741
69Chemokine signaling pathway_Homo sapiens_hsa040620.91043706
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90984734
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.89943555
72Dilated cardiomyopathy_Homo sapiens_hsa054140.87628701
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86166169
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.85711134
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85709979
76Inositol phosphate metabolism_Homo sapiens_hsa005620.85396490
77Hematopoietic cell lineage_Homo sapiens_hsa046400.85091053
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.82702225
79Salmonella infection_Homo sapiens_hsa051320.81165767
80Pancreatic secretion_Homo sapiens_hsa049720.80977376
81Amoebiasis_Homo sapiens_hsa051460.80761126
82VEGF signaling pathway_Homo sapiens_hsa043700.80658180
83Apoptosis_Homo sapiens_hsa042100.80522475
84T cell receptor signaling pathway_Homo sapiens_hsa046600.80060417
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79810413
86MAPK signaling pathway_Homo sapiens_hsa040100.79485705
87Phagosome_Homo sapiens_hsa041450.79156809
88ErbB signaling pathway_Homo sapiens_hsa040120.78654301
89Shigellosis_Homo sapiens_hsa051310.77550025
90Herpes simplex infection_Homo sapiens_hsa051680.77066825
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76868991
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75552373
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.75367230
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.75303970
95B cell receptor signaling pathway_Homo sapiens_hsa046620.74505423
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.73990095
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73355037
98Circadian rhythm_Homo sapiens_hsa047100.73198646
99Malaria_Homo sapiens_hsa051440.73054795
100Thyroid hormone synthesis_Homo sapiens_hsa049180.72712221
101Endocytosis_Homo sapiens_hsa041440.70523165
102Non-small cell lung cancer_Homo sapiens_hsa052230.70392714
103Choline metabolism in cancer_Homo sapiens_hsa052310.70382086
104Lysosome_Homo sapiens_hsa041420.69605459
105Asthma_Homo sapiens_hsa053100.69590270
106Osteoclast differentiation_Homo sapiens_hsa043800.67596365
107Insulin resistance_Homo sapiens_hsa049310.66964253
108Endometrial cancer_Homo sapiens_hsa052130.66865595
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66222126
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65840730
111Dorso-ventral axis formation_Homo sapiens_hsa043200.65644623
112Platelet activation_Homo sapiens_hsa046110.63843044
113Pertussis_Homo sapiens_hsa051330.61319572
114African trypanosomiasis_Homo sapiens_hsa051430.60184306
115Prion diseases_Homo sapiens_hsa050200.59546845
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59341768
117Collecting duct acid secretion_Homo sapiens_hsa049660.59103183
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.58129574
119Renal cell carcinoma_Homo sapiens_hsa052110.58084858
120Thyroid cancer_Homo sapiens_hsa052160.57313076
121Melanogenesis_Homo sapiens_hsa049160.56691921
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56463284
123Prolactin signaling pathway_Homo sapiens_hsa049170.56037744
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55858911
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.55610467
126Chronic myeloid leukemia_Homo sapiens_hsa052200.55535597
127HTLV-I infection_Homo sapiens_hsa051660.54171714
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.54026480
129Type I diabetes mellitus_Homo sapiens_hsa049400.53426074
130Rap1 signaling pathway_Homo sapiens_hsa040150.51829250
131Axon guidance_Homo sapiens_hsa043600.51674242
132Insulin signaling pathway_Homo sapiens_hsa049100.50524889
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.50426761
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50211389
135Glucagon signaling pathway_Homo sapiens_hsa049220.49941938
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49315954
137Colorectal cancer_Homo sapiens_hsa052100.47565337
138Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.47206624
139Cardiac muscle contraction_Homo sapiens_hsa042600.46844717
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45504201
141Bile secretion_Homo sapiens_hsa049760.45490916
142Oocyte meiosis_Homo sapiens_hsa041140.45382554
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43945685
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43907113
145HIF-1 signaling pathway_Homo sapiens_hsa040660.43696531
146Ras signaling pathway_Homo sapiens_hsa040140.43658333
147Primary immunodeficiency_Homo sapiens_hsa053400.42520020
148Acute myeloid leukemia_Homo sapiens_hsa052210.41266920
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40435635

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