PITPNM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.94293893
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68285178
3locomotory exploration behavior (GO:0035641)5.67037965
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.14210278
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.99698603
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.92789909
7vocalization behavior (GO:0071625)4.66011260
8glutamate secretion (GO:0014047)4.60253373
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.48408166
10regulation of synapse structural plasticity (GO:0051823)4.42271396
11regulation of glutamate receptor signaling pathway (GO:1900449)4.39763716
12synaptic vesicle exocytosis (GO:0016079)4.35815086
13negative regulation of erythrocyte differentiation (GO:0045647)4.20586862
14regulation of synaptic vesicle exocytosis (GO:2000300)4.19921302
15regulation of neuronal synaptic plasticity (GO:0048168)4.19324903
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.08096563
17sodium ion export (GO:0071436)4.06669009
18exploration behavior (GO:0035640)4.05344766
19layer formation in cerebral cortex (GO:0021819)4.03674179
20regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94097979
21activation of protein kinase A activity (GO:0034199)3.91829955
22cell communication by electrical coupling (GO:0010644)3.87576221
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85403601
24regulation of synaptic vesicle transport (GO:1902803)3.81711827
25protein localization to synapse (GO:0035418)3.80758101
26neurotransmitter secretion (GO:0007269)3.79735529
27thymic T cell selection (GO:0045061)3.78891514
28neurotransmitter-gated ion channel clustering (GO:0072578)3.77241880
29positive thymic T cell selection (GO:0045059)3.73956291
30dendritic spine morphogenesis (GO:0060997)3.71502252
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.64574070
32cellular potassium ion homeostasis (GO:0030007)3.61883735
33proline transport (GO:0015824)3.55342213
34regulation of ARF protein signal transduction (GO:0032012)3.51194023
35long-term memory (GO:0007616)3.45183459
36positive T cell selection (GO:0043368)3.41881392
37T cell selection (GO:0045058)3.40800935
38neuromuscular process controlling balance (GO:0050885)3.39860842
39regulation of dendritic spine morphogenesis (GO:0061001)3.39038188
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.38819537
41mannose metabolic process (GO:0006013)3.37487811
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36865300
43negative thymic T cell selection (GO:0045060)3.36457884
44synaptic transmission, glutamatergic (GO:0035249)3.33318884
45negative T cell selection (GO:0043383)3.32483356
46signal complex assembly (GO:0007172)3.32222357
47gamma-aminobutyric acid transport (GO:0015812)3.30780860
48regulation of gamma-delta T cell differentiation (GO:0045586)3.29281558
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27303138
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.25846329
51negative regulation of cell killing (GO:0031342)3.25778402
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.25778402
53neuronal action potential propagation (GO:0019227)3.24920005
54positive regulation of granulocyte differentiation (GO:0030854)3.22873784
55positive regulation of membrane potential (GO:0045838)3.22173618
56cerebellar granule cell differentiation (GO:0021707)3.21946408
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21796611
58cell communication involved in cardiac conduction (GO:0086065)3.21352538
59positive regulation of synapse maturation (GO:0090129)3.18623686
60regulation of synaptic plasticity (GO:0048167)3.18173659
61positive regulation of gamma-delta T cell activation (GO:0046645)3.16728660
62membrane depolarization during action potential (GO:0086010)3.15831054
63B cell receptor signaling pathway (GO:0050853)3.15174217
64positive regulation of CREB transcription factor activity (GO:0032793)3.12371798
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12293589
66positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06503201
67regulation of postsynaptic membrane potential (GO:0060078)3.06099532
68prepulse inhibition (GO:0060134)3.05660392
69cellular sodium ion homeostasis (GO:0006883)3.05426207
70glutamate receptor signaling pathway (GO:0007215)3.03619787
71positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.03349346
72neuron-neuron synaptic transmission (GO:0007270)2.98602162
73regulation of B cell receptor signaling pathway (GO:0050855)2.97281583
74glycine transport (GO:0015816)2.95920036
75potassium ion import (GO:0010107)2.94783019
76auditory behavior (GO:0031223)2.90317428
77cytoskeletal anchoring at plasma membrane (GO:0007016)2.90084859
78dendrite morphogenesis (GO:0048813)2.89285307
79negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87509058
80cerebellar Purkinje cell differentiation (GO:0021702)2.87350632
81negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86560264
82alanine transport (GO:0032328)2.83391690
83establishment of nucleus localization (GO:0040023)2.83320264
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.82999282
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.82923321
86regulation of gamma-delta T cell activation (GO:0046643)2.79830594
87neurotransmitter transport (GO:0006836)2.79138762
88regulation of synaptic transmission, glutamatergic (GO:0051966)2.78568986
89regulation of T-helper 2 cell differentiation (GO:0045628)2.78544873
90regulation of neurotransmitter secretion (GO:0046928)2.77803700
91neuronal ion channel clustering (GO:0045161)2.75911414
92positive regulation of neurotransmitter secretion (GO:0001956)2.75278437
93membrane repolarization (GO:0086009)2.75096136
94membrane depolarization (GO:0051899)2.73952235
95neuromuscular process controlling posture (GO:0050884)2.73811035
96mucosal-associated lymphoid tissue development (GO:0048537)2.73376585
97Peyers patch development (GO:0048541)2.73376585
98positive regulation of neurotransmitter transport (GO:0051590)2.73093251
99dendritic spine organization (GO:0097061)2.72867785
100regulation of dendritic spine development (GO:0060998)2.72263874
101vesicle transport along microtubule (GO:0047496)2.71922296
102regulation of neurotransmitter levels (GO:0001505)2.71546197
103regulation of ARF GTPase activity (GO:0032312)2.69245674
104regulation of Rap GTPase activity (GO:0032317)2.68912225
105neuron cell-cell adhesion (GO:0007158)2.68386550
106tolerance induction (GO:0002507)2.68213134
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68064813
108positive regulation of dendritic spine development (GO:0060999)2.67815432
109activation of JUN kinase activity (GO:0007257)2.66746660
110regulation of synapse maturation (GO:0090128)2.66701560
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66562458
112nerve growth factor signaling pathway (GO:0038180)2.66044062
113negative regulation of myotube differentiation (GO:0010832)2.65801229
114regulation of membrane repolarization (GO:0060306)2.65380155
115innervation (GO:0060384)2.64377465
116positive regulation of fibroblast migration (GO:0010763)2.64253111
117chemosensory behavior (GO:0007635)2.63708047
118long-term synaptic potentiation (GO:0060291)2.63346171
119response to auditory stimulus (GO:0010996)2.63276752
120regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62932271
121regulation of ion transmembrane transporter activity (GO:0032412)2.60853177
122cerebellar Purkinje cell layer development (GO:0021680)2.60597596
123plasma membrane repair (GO:0001778)2.58555335
124regulation of neurotransmitter transport (GO:0051588)2.57883488
125neuromuscular process (GO:0050905)2.57254903
126synaptic vesicle endocytosis (GO:0048488)2.57026055
127positive regulation of Rap GTPase activity (GO:0032854)2.56730673
128dopamine receptor signaling pathway (GO:0007212)2.56634043
129regulation of platelet aggregation (GO:0090330)2.54812337
130protein targeting to plasma membrane (GO:0072661)2.48635310
131antigen processing and presentation of endogenous antigen (GO:0019883)2.47478397
132histone H3-K36 demethylation (GO:0070544)2.46374251
133megakaryocyte development (GO:0035855)2.45089463
134response to laminar fluid shear stress (GO:0034616)2.45004144
135adenosine receptor signaling pathway (GO:0001973)2.42890825
136positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.42775386
137regulation of histone H3-K27 methylation (GO:0061085)2.41470076
138histone H4 deacetylation (GO:0070933)2.41103901
139regulation of granulocyte differentiation (GO:0030852)2.37993070
140L-amino acid import (GO:0043092)2.37980056
141positive regulation of protein dephosphorylation (GO:0035307)2.37974992
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37339102
143apoptotic process involved in morphogenesis (GO:0060561)2.36745490
144histone H3 deacetylation (GO:0070932)2.36020079
145cell-substrate adherens junction assembly (GO:0007045)2.34553625
146focal adhesion assembly (GO:0048041)2.34553625
147negative regulation of T-helper cell differentiation (GO:0045623)2.34475641
148negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.34475641
149positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.34460560
150cellular response to epinephrine stimulus (GO:0071872)2.33670439
151response to interleukin-15 (GO:0070672)2.30359595
152peptidyl-glutamic acid carboxylation (GO:0017187)2.27116170
153protein carboxylation (GO:0018214)2.27116170
154response to muramyl dipeptide (GO:0032495)2.23911670
155angiogenesis involved in wound healing (GO:0060055)2.23047750
156regulation of extracellular matrix disassembly (GO:0010715)2.23013925
157regulation of leukocyte degranulation (GO:0043300)2.21655821
158regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21620772
159regulation of regulated secretory pathway (GO:1903305)2.20746900
160amino acid import (GO:0043090)2.20638914
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.20505028
162receptor recycling (GO:0001881)2.18991928
163adherens junction assembly (GO:0034333)2.14730334
164blood coagulation, intrinsic pathway (GO:0007597)2.13734570
165negative regulation of Ras protein signal transduction (GO:0046580)2.10952459
166negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.10305428
167myelin maintenance (GO:0043217)2.09786855
168triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.09649015
169leukocyte aggregation (GO:0070486)2.08964434
170germinal center formation (GO:0002467)2.08232160
171negative regulation of fibrinolysis (GO:0051918)2.06366964
172regulation of amyloid precursor protein catabolic process (GO:1902991)2.05673627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04655668
2MYC_22102868_ChIP-Seq_BL_Human3.00944019
3* RARB_27405468_Chip-Seq_BRAIN_Mouse2.96169948
4DROSHA_22980978_ChIP-Seq_HELA_Human2.82723257
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.67011217
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56967902
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55038062
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51583443
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43954710
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43699797
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43699797
12VDR_21846776_ChIP-Seq_THP-1_Human2.43000978
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34561585
14* REST_21632747_ChIP-Seq_MESCs_Mouse2.33511006
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29204108
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28266773
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.17338951
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07618753
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06113917
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.04843064
21* ELK3_25401928_ChIP-Seq_HUVEC_Human2.03530290
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02783663
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.02106059
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97703255
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94742862
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94189316
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.93831942
28GBX2_23144817_ChIP-Seq_PC3_Human1.91543753
29RUNX_20019798_ChIP-Seq_JUKART_Human1.87397155
30* KDM2B_26808549_Chip-Seq_K562_Human1.82195991
31SCL_19346495_ChIP-Seq_HPC-7_Human1.81621448
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77673753
33* GATA1_19941827_ChIP-Seq_MEL_Mouse1.75088565
34* UTX_26944678_Chip-Seq_JUKART_Human1.75031449
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74801211
36* MAF_26560356_Chip-Seq_TH1_Human1.73380943
37P68_20966046_ChIP-Seq_HELA_Human1.70832524
38* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.70287238
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.70067265
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69679432
41* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68954799
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66137480
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65966421
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65427156
45* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64028979
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62496881
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61355595
48MAF_26560356_Chip-Seq_TH2_Human1.58191649
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.57862838
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.57736103
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57057461
52VDR_24763502_ChIP-Seq_THP-1_Human1.57050794
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54580331
54* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54269069
55RUNX1_22412390_ChIP-Seq_EML_Mouse1.52888792
56RACK7_27058665_Chip-Seq_MCF-7_Human1.52592153
57* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52200326
58AR_21572438_ChIP-Seq_LNCaP_Human1.49248004
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48907581
60KDM2B_26808549_Chip-Seq_DND41_Human1.47573975
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42685012
62* LXR_22292898_ChIP-Seq_THP-1_Human1.41885590
63SPI1_23127762_ChIP-Seq_K562_Human1.41587150
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41076541
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38301081
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.37330471
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.36259046
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33686958
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.32713655
70DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29572448
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28976864
72* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28968345
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27015074
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.26978886
75CTCF_27219007_Chip-Seq_Bcells_Human1.26600813
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25620563
77* BCOR_27268052_Chip-Seq_Bcells_Human1.25600275
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.24177428
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.23515854
80* AR_19668381_ChIP-Seq_PC3_Human1.22234942
81* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19899399
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18458130
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15370941
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15338208
85* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15122975
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.14689002
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14665736
88SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14099012
89IRF8_22096565_ChIP-ChIP_GC-B_Human1.14078687
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13156051
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.12384418
92ESR1_20079471_ChIP-ChIP_T-47D_Human1.11340904
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.10421173
94SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10201687
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09386480
96ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08769662
97* RXR_22158963_ChIP-Seq_LIVER_Mouse1.08144514
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.07820306
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07756086
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07518541
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07367899
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07276518
103BCL6_27268052_Chip-Seq_Bcells_Human1.07124931
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06515828
105SMC4_20622854_ChIP-Seq_HELA_Human1.04095737
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04082437
107SMAD4_21799915_ChIP-Seq_A2780_Human1.03402727
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.02598898
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02581676
110TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02376954
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01873552
112CREB1_26743006_Chip-Seq_LNCaP_Human1.01314589
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00911289
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00871594
115ZNF263_19887448_ChIP-Seq_K562_Human1.00777116
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00683129
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.00462193
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00107578
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.00008166
120TP63_22573176_ChIP-Seq_HFKS_Human0.99127604
121* MYB_26560356_Chip-Seq_TH1_Human0.98939614
122NCOR1_26117541_ChIP-Seq_K562_Human0.97074406
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97024046
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97014587
125* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96739450
126KLF4_19829295_ChIP-Seq_ESCs_Human0.96662866
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96300822
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95389432
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95380634
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95142610
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95136206
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.94654081
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94110346
134MYB_26560356_Chip-Seq_TH2_Human0.93660302
135ZNF274_21170338_ChIP-Seq_K562_Hela0.93113310
136GATA2_19941826_ChIP-Seq_K562_Human0.92981701
137* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92611720
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90915888
139STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90462783
140* AHR_22903824_ChIP-Seq_MCF-7_Human0.90286656
141* EP300_21415370_ChIP-Seq_HL-1_Mouse0.90082919
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89805523
143NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89649020
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.86939979
145TCF7_22412390_ChIP-Seq_EML_Mouse0.85648518
146* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85525007
147STAT3_23295773_ChIP-Seq_U87_Human0.85423745
148* OCT4_19829295_ChIP-Seq_ESCs_Human0.85299181
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84545497
150* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84302038
151* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83571696
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82607693
153* ARNT_22903824_ChIP-Seq_MCF-7_Human0.81921447
154OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80780988
155RXR_22108803_ChIP-Seq_LS180_Human0.80559388
156CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80526749
157PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80477749
158GATA1_19941826_ChIP-Seq_K562_Human0.79648373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.25356741
2MP0002822_catalepsy4.19101425
3MP0003635_abnormal_synaptic_transmissio3.95229649
4MP0004270_analgesia3.46259827
5MP0003763_abnormal_thymus_physiology3.19119533
6MP0002063_abnormal_learning/memory/cond3.15244353
7MP0003880_abnormal_central_pattern3.07897554
8MP0009745_abnormal_behavioral_response3.06665415
9MP0002064_seizures2.68898874
10MP0005464_abnormal_platelet_physiology2.66495134
11MP0001968_abnormal_touch/_nociception2.59661365
12MP0002909_abnormal_adrenal_gland2.44868714
13MP0005409_darkened_coat_color2.42691595
14MP0002572_abnormal_emotion/affect_behav2.39842473
15MP0003172_abnormal_lysosome_physiology2.39599289
16MP0009780_abnormal_chondrocyte_physiolo2.38879746
17MP0003436_decreased_susceptibility_to2.31699446
18MP0004858_abnormal_nervous_system2.27569135
19MP0009046_muscle_twitch2.24111703
20MP0005423_abnormal_somatic_nervous2.23297473
21MP0008961_abnormal_basal_metabolism2.20629453
22MP0004381_abnormal_hair_follicle2.16141222
23MP0002735_abnormal_chemical_nociception2.16118398
24MP0000751_myopathy2.09330841
25MP0002272_abnormal_nervous_system2.09251130
26MP0002734_abnormal_mechanical_nocicepti2.08371823
27MP0001348_abnormal_lacrimal_gland2.02662824
28MP0003329_amyloid_beta_deposits2.00100256
29MP0001486_abnormal_startle_reflex1.99848027
30MP0002837_dystrophic_cardiac_calcinosis1.97085931
31MP0008569_lethality_at_weaning1.89969325
32MP0001501_abnormal_sleep_pattern1.85920010
33MP0002736_abnormal_nociception_after1.82806802
34MP0002733_abnormal_thermal_nociception1.77247975
35MP0004811_abnormal_neuron_physiology1.76667825
36MP0001440_abnormal_grooming_behavior1.67566974
37MP0003303_peritoneal_inflammation1.66787959
38MP0001970_abnormal_pain_threshold1.66717855
39MP0005451_abnormal_body_composition1.66093475
40MP0004130_abnormal_muscle_cell1.64619459
41MP0001800_abnormal_humoral_immune1.63828078
42MP0009840_abnormal_foam_cell1.61374107
43MP0000703_abnormal_thymus_morphology1.54534605
44MP0003300_gastrointestinal_ulcer1.54395923
45MP0004947_skin_inflammation1.53668087
46MP0003879_abnormal_hair_cell1.52144326
47MP0002398_abnormal_bone_marrow1.50567912
48MP0001986_abnormal_taste_sensitivity1.47930103
49MP0000685_abnormal_immune_system1.47903132
50MP0005387_immune_system_phenotype1.45589511
51MP0001790_abnormal_immune_system1.45589511
52MP0004924_abnormal_behavior1.44826128
53MP0005386_behavior/neurological_phenoty1.44826128
54MP0008260_abnormal_autophagy1.43457847
55MP0001851_eye_inflammation1.42793881
56MP0004215_abnormal_myocardial_fiber1.42736117
57MP0005000_abnormal_immune_tolerance1.42012824
58MP0003633_abnormal_nervous_system1.41399651
59MP0002067_abnormal_sensory_capabilities1.41113525
60MP0002138_abnormal_hepatobiliary_system1.39228754
61MP0000465_gastrointestinal_hemorrhage1.37258311
62MP0003191_abnormal_cellular_cholesterol1.37016137
63MP0002557_abnormal_social/conspecific_i1.36258126
64MP0005670_abnormal_white_adipose1.35716521
65MP0003075_altered_response_to1.35651878
66MP0003091_abnormal_cell_migration1.35244732
67MP0004085_abnormal_heartbeat1.33769245
68MP0002396_abnormal_hematopoietic_system1.32920703
69MP0000955_abnormal_spinal_cord1.32505870
70MP0002184_abnormal_innervation1.31110291
71MP0009278_abnormal_bone_marrow1.29428860
72MP0005076_abnormal_cell_differentiation1.29198822
73MP0005666_abnormal_adipose_tissue1.29139606
74MP0004510_myositis1.28092034
75MP0004084_abnormal_cardiac_muscle1.26501615
76MP0003724_increased_susceptibility_to1.26082280
77MP0002420_abnormal_adaptive_immunity1.25697790
78MP0001873_stomach_inflammation1.25313574
79MP0002723_abnormal_immune_serum1.23082513
80MP0003283_abnormal_digestive_organ1.22619495
81MP0001819_abnormal_immune_cell1.22334193
82MP0008874_decreased_physiological_sensi1.22241593
83MP0003646_muscle_fatigue1.21697951
84MP0004036_abnormal_muscle_relaxation1.20789280
85MP0003566_abnormal_cell_adhesion1.18745777
86MP0002066_abnormal_motor_capabilities/c1.18553399
87MP0005058_abnormal_lysosome_morphology1.18357535
88MP0005167_abnormal_blood-brain_barrier1.18211634
89MP0000716_abnormal_immune_system1.17149729
90MP0009333_abnormal_splenocyte_physiolog1.16984625
91MP0002933_joint_inflammation1.16803693
92MP0003183_abnormal_peptide_metabolism1.15556323
93MP0002722_abnormal_immune_system1.14443594
94MP0004885_abnormal_endolymph1.13011147
95MP0000013_abnormal_adipose_tissue1.12696374
96MP0004185_abnormal_adipocyte_glucose1.12369859
97MP0002882_abnormal_neuron_morphology1.10689021
98MP0003137_abnormal_impulse_conducting1.10321974
99MP0003279_aneurysm1.09610822
100MP0005646_abnormal_pituitary_gland1.09344341
101MP0005360_urolithiasis1.08403468
102MP0003631_nervous_system_phenotype1.06491224
103MP0001835_abnormal_antigen_presentation1.06262347
104MP0005535_abnormal_body_temperature1.05553657
105MP0000778_abnormal_nervous_system1.05453740
106MP0002089_abnormal_postnatal_growth/wei1.04865872
107MP0002405_respiratory_system_inflammati1.04141585
108MP0010155_abnormal_intestine_physiology1.03661610
109MP0001849_ear_inflammation1.02953922
110MP0004233_abnormal_muscle_weight1.02502185
111MP0000689_abnormal_spleen_morphology1.01769918
112MP0002452_abnormal_antigen_presenting1.00462604
113MP0010234_abnormal_vibrissa_follicle1.00002603
114MP0004145_abnormal_muscle_electrophysio0.98775265
115MP0001502_abnormal_circadian_rhythm0.97329143
116MP0000604_amyloidosis0.97306675
117MP0003787_abnormal_imprinting0.97303277
118MP0008872_abnormal_physiological_respon0.96632662
119MP0002429_abnormal_blood_cell0.94595954
120MP0004087_abnormal_muscle_fiber0.93329539
121MP0002069_abnormal_eating/drinking_beha0.92756294
122MP0000678_abnormal_parathyroid_gland0.92200821
123MP0005025_abnormal_response_to0.91120850
124MP0008004_abnormal_stomach_pH0.90812654
125MP0000747_muscle_weakness0.89076617
126MP0003866_abnormal_defecation0.87729094
127MP0001765_abnormal_ion_homeostasis0.86940945
128MP0005620_abnormal_muscle_contractility0.86854677
129MP0009115_abnormal_fat_cell0.86687992
130MP0005671_abnormal_response_to0.86524244
131MP0000249_abnormal_blood_vessel0.85572141
132MP0005330_cardiomyopathy0.85380058
133MP0001177_atelectasis0.84789631
134MP0002152_abnormal_brain_morphology0.84282057
135MP0004484_altered_response_of0.83528646
136MP0005310_abnormal_salivary_gland0.83086348
137MP0002269_muscular_atrophy0.81328773
138MP0000749_muscle_degeneration0.80570879
139MP0002419_abnormal_innate_immunity0.79874479
140MP0002090_abnormal_vision0.79008026
141MP0003045_fibrosis0.78100367
142MP0005085_abnormal_gallbladder_physiolo0.77898647
143MP0000569_abnormal_digit_pigmentation0.76812627
144MP0002234_abnormal_pharynx_morphology0.76100357
145MP0005187_abnormal_penis_morphology0.75961239
146MP0002972_abnormal_cardiac_muscle0.75715865
147MP0001984_abnormal_olfaction0.75690396
148MP0003690_abnormal_glial_cell0.74849309
149MP0000003_abnormal_adipose_tissue0.71938000
150MP0010368_abnormal_lymphatic_system0.71088951
151MP0010329_abnormal_lipoprotein_level0.69658083
152MP0002229_neurodegeneration0.69551050
153MP0006138_congestive_heart_failure0.69233875
154MP0005623_abnormal_meninges_morphology0.68571946
155MP0008775_abnormal_heart_ventricle0.68208122
156MP0002078_abnormal_glucose_homeostasis0.65249562
157MP0003705_abnormal_hypodermis_morpholog0.64920793
158MP0006276_abnormal_autonomic_nervous0.61402386
159MP0001544_abnormal_cardiovascular_syste0.59988042
160MP0005385_cardiovascular_system_phenoty0.59988042
161MP0000759_abnormal_skeletal_muscle0.59987525
162MP0005365_abnormal_bile_salt0.59585899
163MP0005166_decreased_susceptibility_to0.59409947
164MP0005375_adipose_tissue_phenotype0.59217973

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.61814092
2Focal motor seizures (HP:0011153)5.31494320
3Focal seizures (HP:0007359)4.60067873
4Visual hallucinations (HP:0002367)4.25140155
5Prolonged bleeding time (HP:0003010)4.17878146
6Abnormality of the lower motor neuron (HP:0002366)3.89488557
7Menorrhagia (HP:0000132)3.80916869
8Action tremor (HP:0002345)3.71525896
9Abnormality of binocular vision (HP:0011514)3.69526115
10Diplopia (HP:0000651)3.69526115
11Epistaxis (HP:0000421)3.42691945
12Ventricular fibrillation (HP:0001663)3.42012535
13Bundle branch block (HP:0011710)3.33350944
14Poor eye contact (HP:0000817)3.28227018
15Dysmetric saccades (HP:0000641)3.27070727
16Impaired social interactions (HP:0000735)3.22936911
17Abnormal social behavior (HP:0012433)3.22936911
18Impaired vibration sensation in the lower limbs (HP:0002166)3.21684866
19Epileptic encephalopathy (HP:0200134)3.19697292
20Depression (HP:0000716)3.19343492
21Ankle clonus (HP:0011448)3.17421168
22Hyperlipoproteinemia (HP:0010980)3.14676379
23Abnormality of the fingertips (HP:0001211)3.11286256
24Deep venous thrombosis (HP:0002625)3.09260924
25Purpura (HP:0000979)3.08712353
26Sudden death (HP:0001699)3.07587425
27Supranuclear gaze palsy (HP:0000605)3.05215834
28Joint hemorrhage (HP:0005261)3.03480063
29Abnormal platelet volume (HP:0011876)3.02754415
30Progressive cerebellar ataxia (HP:0002073)2.98270922
31Papilledema (HP:0001085)2.95765452
32Annular pancreas (HP:0001734)2.95097741
33Generalized tonic-clonic seizures (HP:0002069)2.94272481
34Febrile seizures (HP:0002373)2.88997788
35Torticollis (HP:0000473)2.88964638
36Urinary bladder sphincter dysfunction (HP:0002839)2.86827343
37Postural instability (HP:0002172)2.86440355
38Broad face (HP:0000283)2.85885508
39Increased mean platelet volume (HP:0011877)2.83681062
40Hemorrhage of the eye (HP:0011885)2.81248667
41Absence seizures (HP:0002121)2.80747369
42Urinary urgency (HP:0000012)2.77560867
43Atonic seizures (HP:0010819)2.74770613
44Hemiplegia (HP:0002301)2.74134013
45Dysdiadochokinesis (HP:0002075)2.73848707
46Insomnia (HP:0100785)2.68963141
47Anxiety (HP:0000739)2.67264043
48Gingival bleeding (HP:0000225)2.61456760
49Focal dystonia (HP:0004373)2.57915203
50Cerebral aneurysm (HP:0004944)2.55483304
51Pointed chin (HP:0000307)2.55047245
52Dysmetria (HP:0001310)2.54522996
53Dialeptic seizures (HP:0011146)2.53051756
54Exercise-induced myalgia (HP:0003738)2.52498856
55Panhypogammaglobulinemia (HP:0003139)2.50303063
56Genetic anticipation (HP:0003743)2.49115710
57Resting tremor (HP:0002322)2.47924373
58Eczematoid dermatitis (HP:0000976)2.45341333
59Agammaglobulinemia (HP:0004432)2.45103211
60Prolonged QT interval (HP:0001657)2.45040311
61Gaze-evoked nystagmus (HP:0000640)2.41173748
62Colitis (HP:0002583)2.40258125
63Cellulitis (HP:0100658)2.40109290
64Truncal ataxia (HP:0002078)2.39152365
65Spontaneous hematomas (HP:0007420)2.38504310
66Impaired smooth pursuit (HP:0007772)2.38402238
67Craniofacial dystonia (HP:0012179)2.35750914
68Abnormal EKG (HP:0003115)2.35710833
69Broad-based gait (HP:0002136)2.35706837
70Heart block (HP:0012722)2.35468590
71Atrioventricular block (HP:0001678)2.35307591
72Papilloma (HP:0012740)2.30072416
73Verrucae (HP:0200043)2.30072416
74Hyperacusis (HP:0010780)2.29360533
75Lower limb amyotrophy (HP:0007210)2.28390566
76Primary atrial arrhythmia (HP:0001692)2.25740088
77Stereotypic behavior (HP:0000733)2.25032413
78Impaired vibratory sensation (HP:0002495)2.24741523
79Spastic gait (HP:0002064)2.24356022
80Syncope (HP:0001279)2.22097445
81Gastrointestinal inflammation (HP:0004386)2.22060495
82Atrial fibrillation (HP:0005110)2.21365182
83Bradykinesia (HP:0002067)2.19867281
84Cerebral inclusion bodies (HP:0100314)2.19141537
85Amblyopia (HP:0000646)2.19121915
86Status epilepticus (HP:0002133)2.18394579
87Megalencephaly (HP:0001355)2.16086443
88Rapidly progressive (HP:0003678)2.15810122
89Abnormal atrioventricular conduction (HP:0005150)2.14895491
90Insidious onset (HP:0003587)2.14116519
91Termporal pattern (HP:0011008)2.14116519
92Intention tremor (HP:0002080)2.12825375
93Difficulty running (HP:0009046)2.12137729
94Abnormality of ocular smooth pursuit (HP:0000617)2.12099354
95Slow saccadic eye movements (HP:0000514)2.11147914
96Abnormal eating behavior (HP:0100738)2.10620738
97Macroorchidism (HP:0000053)2.09619760
98Distal lower limb amyotrophy (HP:0008944)2.09531865
99Supraventricular tachycardia (HP:0004755)2.09506960
100Abnormal platelet function (HP:0011869)2.07964808
101Impaired platelet aggregation (HP:0003540)2.07964808
102Supraventricular arrhythmia (HP:0005115)2.07441211
103Ventricular arrhythmia (HP:0004308)2.05399638
104Obstructive sleep apnea (HP:0002870)2.05387580
105Onion bulb formation (HP:0003383)2.03420598
106Increased IgE level (HP:0003212)2.02029463
107Inflammation of the large intestine (HP:0002037)2.01542205
108Meningitis (HP:0001287)1.99551344
109Abnormality of the common coagulation pathway (HP:0010990)1.96898919
110Gastrointestinal stroma tumor (HP:0100723)1.96816233
111Upper limb amyotrophy (HP:0009129)1.96784946
112Distal upper limb amyotrophy (HP:0007149)1.96784946
113Epileptiform EEG discharges (HP:0011182)1.96318472
114Ankyloglossia (HP:0010296)1.95771300
115EEG with generalized epileptiform discharges (HP:0011198)1.95607926
116Neoplasm of the heart (HP:0100544)1.95466733
117Lower limb muscle weakness (HP:0007340)1.95434912
118Hypsarrhythmia (HP:0002521)1.94708099
119Petechiae (HP:0000967)1.94558872
120Abnormality of the columella (HP:0009929)1.94343794
121Elfin facies (HP:0004428)1.94261433
122Xanthomatosis (HP:0000991)1.93603526
123Scanning speech (HP:0002168)1.93004351
124Hemiparesis (HP:0001269)1.92246256
125Hypercortisolism (HP:0001578)1.91920244
126Mutism (HP:0002300)1.91783678
127Achilles tendon contracture (HP:0001771)1.91760804
128Hyporeflexia of lower limbs (HP:0002600)1.91009152
129Abnormality of the Achilles tendon (HP:0005109)1.89207365
130Neurofibrillary tangles (HP:0002185)1.88555262
131Emphysema (HP:0002097)1.87986662
132Myotonia (HP:0002486)1.84832757
133Hyperventilation (HP:0002883)1.84652387
134Persistence of primary teeth (HP:0006335)1.84146975
135Clonus (HP:0002169)1.83286314
136Spinal canal stenosis (HP:0003416)1.82511978
137Dislocated radial head (HP:0003083)1.81686570
138Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81482472
139Abnormality of pain sensation (HP:0010832)1.80856229
140Impaired pain sensation (HP:0007328)1.80856229
141Lower limb asymmetry (HP:0100559)1.80676270
142Increased variability in muscle fiber diameter (HP:0003557)1.80236650
143Neuronal loss in central nervous system (HP:0002529)1.79273050
144Gastrointestinal infarctions (HP:0005244)1.77944345
145Dysostosis multiplex (HP:0000943)1.77480398
146Polygenic inheritance (HP:0010982)1.77238677
147Pustule (HP:0200039)1.75726240
148Easy fatigability (HP:0003388)1.75315031
149Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73088806
150Mucopolysacchariduria (HP:0008155)1.72564238
151Urinary glycosaminoglycan excretion (HP:0003541)1.72564238
152Complement deficiency (HP:0004431)1.72526282
153Hypoplasia of the thymus (HP:0000778)1.71970223
154Bowel incontinence (HP:0002607)1.71216964
155Prolonged partial thromboplastin time (HP:0003645)1.69588238
156Abnormality of skeletal muscle fiber size (HP:0012084)1.68479170
157Pulmonary embolism (HP:0002204)1.67601264
158Chest pain (HP:0100749)1.67572843
159Recurrent fungal infections (HP:0002841)1.66308281
160Truncus arteriosus (HP:0001660)1.66301459
161Thin bony cortex (HP:0002753)1.66255568
162Severe combined immunodeficiency (HP:0004430)1.65540052
163Growth hormone excess (HP:0000845)1.65416547
164Supernumerary nipples (HP:0002558)1.64125534
165Aneurysm (HP:0002617)1.63678303
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61662305
167Abnormality of polysaccharide metabolism (HP:0011012)1.61662305
168Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61662305
169Centrally nucleated skeletal muscle fibers (HP:0003687)1.60993383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.10953996
2NTRK33.85125638
3MAP3K93.68438940
4PRKD33.06454782
5DAPK22.83194533
6MAP4K12.77915813
7ERN12.75732322
8KSR22.61127638
9PAK62.27341796
10TRIB32.26706809
11MINK12.16445967
12MARK12.10810180
13CAMKK12.07996179
14CDK122.05278854
15MAP3K42.04604665
16TAOK11.84153773
17SMG11.83682563
18NTRK21.81130160
19NTRK11.75932366
20SIK21.68820297
21PKN21.59941702
22SIK31.57092453
23GRK61.56171979
24LMTK21.55838838
25TYRO31.54083785
26STK381.53633865
27FGFR41.50617239
28MAP2K41.47318379
29ZAP701.45755654
30PRKCH1.44273263
31RIPK11.43374628
32KSR11.41458746
33PHKG11.41388606
34PHKG21.41388606
35MAP3K21.38719930
36CDK51.37484177
37MAP3K71.35026278
38DAPK11.34881190
39MAPK111.31169177
40RET1.25955758
41MAP3K131.23151637
42MARK21.15942055
43CAMK11.14538005
44MAP2K31.14463738
45BTK1.13510131
46MAP2K71.10935325
47ALK1.10383707
48FES1.08578959
49PRPF4B1.07416652
50SGK31.05185558
51DMPK1.05056764
52HIPK21.04235597
53SYK1.00667748
54LATS20.98906727
55BLK0.98611412
56MAP3K10.97825959
57CAMK1G0.96125390
58JAK10.94788182
59PDGFRA0.94592654
60UHMK10.92819419
61NLK0.92321167
62PDK10.91265236
63PINK10.91098723
64HCK0.90884514
65STK110.90562487
66PTK2B0.90495154
67PAK30.88656946
68PRKCG0.87016231
69GRK50.86230793
70FGFR30.85208645
71ICK0.83493409
72RIPK40.83314058
73EPHB10.82752583
74PDPK10.82682505
75NEK10.81148442
76TYK20.80520323
77CAMK40.78908451
78SGK20.78407728
79BMPR20.77770184
80CDC42BPA0.77555869
81ITK0.77184576
82RAF10.76193589
83MAPK70.75461529
84TXK0.75452092
85SGK2230.75094476
86SGK4940.75094476
87ARAF0.72029732
88EEF2K0.66498037
89FGFR20.66080790
90CAMKK20.64453659
91TNK20.64444447
92PRKD20.64297128
93IRAK20.61943800
94SGK10.61908365
95CAMK2A0.60709434
96MTOR0.60690627
97CDK150.60000424
98MAP2K20.59865185
99CDK180.58072297
100SIK10.57335777
101MAP3K110.57103828
102CDK40.56322623
103RPS6KA30.56270429
104MAPK120.54243580
105MAPK130.53391098
106LCK0.52867957
107PRKD10.52371312
108CDK140.52359980
109TNIK0.51747779
110CSK0.51629551
111CDK11A0.50981354
112MAPK40.50287595
113MAP3K30.50112179
114MAP3K100.49973428
115PRKCZ0.48424236
116RPS6KA20.48369837
117MELK0.47277472
118FYN0.45862951
119MAP2K10.45763313
120DAPK30.45576030
121TTN0.44610823
122MAP3K60.43932437
123SCYL20.43479090
124PDGFRB0.41916815
125NEK60.41533940
126MARK30.41185502
127CAMK1D0.40239217
128MAPK100.39695175
129PTK60.38821236
130CSF1R0.38112558
131BMX0.37722845
132PRKAA10.37035793
133JAK30.36906601
134WNK10.36584010
135JAK20.35805889
136FER0.33780861
137PRKACG0.33388378
138PDK40.32710553
139PDK30.32710553
140MAPK80.32446268

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.50332936
2Olfactory transduction_Homo sapiens_hsa047402.45948972
3Circadian entrainment_Homo sapiens_hsa047132.33869744
4Synaptic vesicle cycle_Homo sapiens_hsa047212.33338935
5Long-term potentiation_Homo sapiens_hsa047202.29695138
6Nicotine addiction_Homo sapiens_hsa050332.20414512
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11131424
8Glutamatergic synapse_Homo sapiens_hsa047242.06226873
9GABAergic synapse_Homo sapiens_hsa047272.04784626
10Amphetamine addiction_Homo sapiens_hsa050311.99858579
11Aldosterone synthesis and secretion_Homo sapiens_hsa049251.98260704
12Insulin secretion_Homo sapiens_hsa049111.96028623
13B cell receptor signaling pathway_Homo sapiens_hsa046621.95997722
14Morphine addiction_Homo sapiens_hsa050321.92760025
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.89568048
16Salivary secretion_Homo sapiens_hsa049701.85461973
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.82447599
18Gastric acid secretion_Homo sapiens_hsa049711.75293690
19Dopaminergic synapse_Homo sapiens_hsa047281.75136616
20Cholinergic synapse_Homo sapiens_hsa047251.75120786
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.68398839
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58722473
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.56075765
24T cell receptor signaling pathway_Homo sapiens_hsa046601.55577253
25Acute myeloid leukemia_Homo sapiens_hsa052211.55112860
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.54267059
27Type II diabetes mellitus_Homo sapiens_hsa049301.49924495
28Renin secretion_Homo sapiens_hsa049241.47546152
29Primary immunodeficiency_Homo sapiens_hsa053401.43188615
30Cocaine addiction_Homo sapiens_hsa050301.41848656
31Calcium signaling pathway_Homo sapiens_hsa040201.39622392
32GnRH signaling pathway_Homo sapiens_hsa049121.38118514
33Chronic myeloid leukemia_Homo sapiens_hsa052201.32935715
34Notch signaling pathway_Homo sapiens_hsa043301.31913534
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26308253
36Glioma_Homo sapiens_hsa052141.25840702
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25220164
38cAMP signaling pathway_Homo sapiens_hsa040241.25210550
39Taste transduction_Homo sapiens_hsa047421.16758604
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16280043
41Estrogen signaling pathway_Homo sapiens_hsa049151.16185310
42Dilated cardiomyopathy_Homo sapiens_hsa054141.16172206
43Gap junction_Homo sapiens_hsa045401.15551604
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14541470
45Arginine biosynthesis_Homo sapiens_hsa002201.12252160
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11304461
47Dorso-ventral axis formation_Homo sapiens_hsa043201.10856411
48Long-term depression_Homo sapiens_hsa047301.10606502
49Osteoclast differentiation_Homo sapiens_hsa043801.10448954
50Bile secretion_Homo sapiens_hsa049761.10349990
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04535607
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98620922
53Pancreatic cancer_Homo sapiens_hsa052120.97513164
54ErbB signaling pathway_Homo sapiens_hsa040120.96585053
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.95617220
56Glucagon signaling pathway_Homo sapiens_hsa049220.94916506
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.92970719
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92392213
59Complement and coagulation cascades_Homo sapiens_hsa046100.91673145
60mTOR signaling pathway_Homo sapiens_hsa041500.90236367
61Serotonergic synapse_Homo sapiens_hsa047260.90102869
62Melanogenesis_Homo sapiens_hsa049160.89903086
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89734508
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88334567
65VEGF signaling pathway_Homo sapiens_hsa043700.87783401
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86872070
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.81747433
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81024873
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80168634
70Insulin signaling pathway_Homo sapiens_hsa049100.80110461
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.79037146
72Pancreatic secretion_Homo sapiens_hsa049720.78556102
73Other glycan degradation_Homo sapiens_hsa005110.78481108
74Axon guidance_Homo sapiens_hsa043600.77455840
75Cardiac muscle contraction_Homo sapiens_hsa042600.76991027
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.76375156
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75229343
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74671945
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74544609
80Colorectal cancer_Homo sapiens_hsa052100.74015813
81Non-small cell lung cancer_Homo sapiens_hsa052230.73575978
82Thyroid hormone synthesis_Homo sapiens_hsa049180.72629061
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.72463376
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72326490
85Choline metabolism in cancer_Homo sapiens_hsa052310.70817858
86FoxO signaling pathway_Homo sapiens_hsa040680.69700844
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69693768
88Endometrial cancer_Homo sapiens_hsa052130.69366663
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.68323564
90Hematopoietic cell lineage_Homo sapiens_hsa046400.67858001
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66757767
92ABC transporters_Homo sapiens_hsa020100.66498517
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65456721
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64900444
95Focal adhesion_Homo sapiens_hsa045100.64590223
96Insulin resistance_Homo sapiens_hsa049310.63476604
97MAPK signaling pathway_Homo sapiens_hsa040100.63410438
98Rap1 signaling pathway_Homo sapiens_hsa040150.62994391
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.61586205
100Hepatitis B_Homo sapiens_hsa051610.60758784
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.60260577
102Oocyte meiosis_Homo sapiens_hsa041140.58617937
103Fatty acid biosynthesis_Homo sapiens_hsa000610.58004736
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.57782886
105Thyroid cancer_Homo sapiens_hsa052160.57428181
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.56953154
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55854087
108Leishmaniasis_Homo sapiens_hsa051400.55788741
109Prion diseases_Homo sapiens_hsa050200.52066765
110Circadian rhythm_Homo sapiens_hsa047100.51425133
111Endocytosis_Homo sapiens_hsa041440.51138708
112Renal cell carcinoma_Homo sapiens_hsa052110.47505531
113AMPK signaling pathway_Homo sapiens_hsa041520.46860595
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46351663
115Ras signaling pathway_Homo sapiens_hsa040140.44723277
116Butanoate metabolism_Homo sapiens_hsa006500.44691391
117Inositol phosphate metabolism_Homo sapiens_hsa005620.43848819
118Prolactin signaling pathway_Homo sapiens_hsa049170.41148861
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39034761
120Platelet activation_Homo sapiens_hsa046110.38942283
121PPAR signaling pathway_Homo sapiens_hsa033200.38423514
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.38120051
123Lysine degradation_Homo sapiens_hsa003100.37503365
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37320824
125Ovarian steroidogenesis_Homo sapiens_hsa049130.36293439
126Glycerolipid metabolism_Homo sapiens_hsa005610.34806144
127Chemokine signaling pathway_Homo sapiens_hsa040620.33910049
128Fatty acid metabolism_Homo sapiens_hsa012120.33830732

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »