PITRM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)7.32811368
2COPI coating of Golgi vesicle (GO:0048205)7.32811368
3DNA unwinding involved in DNA replication (GO:0006268)5.19661865
4nuclear pore organization (GO:0006999)5.19164188
5nuclear pore complex assembly (GO:0051292)5.00973306
6folic acid-containing compound biosynthetic process (GO:0009396)4.97126701
7hemidesmosome assembly (GO:0031581)4.91069480
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.87601876
9IMP biosynthetic process (GO:0006188)4.79627716
10protein localization to kinetochore (GO:0034501)4.65246749
11mitotic nuclear envelope disassembly (GO:0007077)4.49189321
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.47750783
13protein retention in ER lumen (GO:0006621)4.44003070
14protein localization to endosome (GO:0036010)4.42809693
15cell adhesion mediated by integrin (GO:0033627)4.37837622
16skin morphogenesis (GO:0043589)4.36335294
17COPII vesicle coating (GO:0048208)4.25638629
18formation of translation preinitiation complex (GO:0001731)4.23520597
19membrane disassembly (GO:0030397)4.18492482
20nuclear envelope disassembly (GO:0051081)4.18492482
21DNA strand elongation involved in DNA replication (GO:0006271)4.17272088
22IMP metabolic process (GO:0046040)4.16670005
23DNA replication initiation (GO:0006270)4.15769891
24cell-substrate junction assembly (GO:0007044)4.07712164
25vesicle coating (GO:0006901)4.04780182
26nucleobase biosynthetic process (GO:0046112)3.99765829
27DNA strand elongation (GO:0022616)3.95328670
28pore complex assembly (GO:0046931)3.86969795
29DNA replication-dependent nucleosome organization (GO:0034723)3.80685666
30DNA replication-dependent nucleosome assembly (GO:0006335)3.80685666
31protein localization to chromosome, centromeric region (GO:0071459)3.77860901
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71746112
33telomere maintenance via semi-conservative replication (GO:0032201)3.69686521
34DNA duplex unwinding (GO:0032508)3.69118407
35DNA geometric change (GO:0032392)3.66516323
36barbed-end actin filament capping (GO:0051016)3.65868816
37mitotic chromosome condensation (GO:0007076)3.65078319
38mitotic metaphase plate congression (GO:0007080)3.63862438
39protein maturation by protein folding (GO:0022417)3.62218800
40regulation of translational fidelity (GO:0006450)3.60576522
41desmosome organization (GO:0002934)3.59350604
42purine nucleobase biosynthetic process (GO:0009113)3.53360115
43sister chromatid segregation (GO:0000819)3.53159829
44mitotic sister chromatid segregation (GO:0000070)3.49072934
45focal adhesion assembly (GO:0048041)3.46115481
46cell-substrate adherens junction assembly (GO:0007045)3.46115481
47stress fiber assembly (GO:0043149)3.44950015
48regulation of spindle organization (GO:0090224)3.41590518
49activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.41047140
50cytoskeletal anchoring at plasma membrane (GO:0007016)3.38189769
51ribosomal small subunit assembly (GO:0000028)3.33669090
52adherens junction assembly (GO:0034333)3.33383525
53telomere maintenance via recombination (GO:0000722)3.32106831
54mitotic recombination (GO:0006312)3.31898471
55mitotic sister chromatid cohesion (GO:0007064)3.26694178
56metaphase plate congression (GO:0051310)3.26035909
57positive regulation of nuclease activity (GO:0032075)3.23959935
58heterochromatin organization (GO:0070828)3.19813521
59nuclear envelope organization (GO:0006998)3.19135610
60tetrahydrofolate metabolic process (GO:0046653)3.17689362
61endoplasmic reticulum unfolded protein response (GO:0030968)3.17386530
62hypotonic response (GO:0006971)3.16511378
63DNA replication checkpoint (GO:0000076)3.16428398
64regulation of mitotic spindle organization (GO:0060236)3.15939451
65membrane raft organization (GO:0031579)3.14878586
66protein hydroxylation (GO:0018126)3.14808823
67regulation of early endosome to late endosome transport (GO:2000641)3.14623423
68negative regulation of cell size (GO:0045792)3.11995943
69ribosome assembly (GO:0042255)3.09958342
70regulation of translational termination (GO:0006449)3.08351222
71kinetochore organization (GO:0051383)3.08019133
72ER-nucleus signaling pathway (GO:0006984)3.07541796
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07521407
74dosage compensation (GO:0007549)3.07281905
75translesion synthesis (GO:0019985)3.06758480
76attachment of spindle microtubules to kinetochore (GO:0008608)3.04503223
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04493989
78epithelial cell-cell adhesion (GO:0090136)3.04087812
79CENP-A containing nucleosome assembly (GO:0034080)3.02522367
80chromatin remodeling at centromere (GO:0031055)3.01518142
81telomere maintenance via telomere lengthening (GO:0010833)3.00819981
82pre-miRNA processing (GO:0031054)3.00816258
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.99973419
84NADH metabolic process (GO:0006734)2.97565797
85DNA conformation change (GO:0071103)2.96603250
86maturation of SSU-rRNA (GO:0030490)2.95752959
87regulation of histone H3-K9 methylation (GO:0051570)2.95291472
88DNA replication-independent nucleosome assembly (GO:0006336)2.95237246
89DNA replication-independent nucleosome organization (GO:0034724)2.95237246
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.94735580
91cellular response to unfolded protein (GO:0034620)2.94003936
92negative regulation of RNA splicing (GO:0033119)2.93660785
93establishment of chromosome localization (GO:0051303)2.93155467
94peptidyl-proline hydroxylation (GO:0019511)2.92217551
95proline biosynthetic process (GO:0006561)2.90382752
96hyaluronan catabolic process (GO:0030214)2.90242935
97protoporphyrinogen IX metabolic process (GO:0046501)2.90050574
98regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89897120
99folic acid metabolic process (GO:0046655)2.88204288
100postreplication repair (GO:0006301)2.87805089
101chromatin assembly or disassembly (GO:0006333)2.86781352
102positive regulation of chromosome segregation (GO:0051984)2.84262590
103ribosome biogenesis (GO:0042254)2.83680921
104chromatin assembly (GO:0031497)2.83284640
105histone-serine phosphorylation (GO:0035404)2.81696296
106regulation of sister chromatid cohesion (GO:0007063)2.80986967
107regulation of nuclease activity (GO:0032069)2.79626864
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.79153010
109pteridine-containing compound biosynthetic process (GO:0042559)2.78985688
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.77786922
111protein localization to chromosome (GO:0034502)2.76733508
112mannose metabolic process (GO:0006013)2.76326458
113actin filament depolymerization (GO:0030042)2.76173899
114basement membrane organization (GO:0071711)2.73886316
115translational initiation (GO:0006413)2.73641872
116negative regulation of histone methylation (GO:0031061)2.73477332
117spindle assembly checkpoint (GO:0071173)2.72785126
118endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.72660779
119protoporphyrinogen IX biosynthetic process (GO:0006782)2.72509995
120negative regulation of chromosome segregation (GO:0051985)2.71647900
121regulation of chromosome segregation (GO:0051983)2.70512915
122nuclear envelope reassembly (GO:0031468)2.70220075
123mitotic nuclear envelope reassembly (GO:0007084)2.70220075
124membrane protein ectodomain proteolysis (GO:0006509)2.69397384
125pentose-phosphate shunt (GO:0006098)2.68100114
126negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.67906511
127negative regulation of sister chromatid segregation (GO:0033046)2.67906511
128negative regulation of mitotic sister chromatid separation (GO:2000816)2.67906511
129negative regulation of mitotic sister chromatid segregation (GO:0033048)2.67906511
130mitotic spindle assembly checkpoint (GO:0007094)2.67539755
131regulation of centrosome cycle (GO:0046605)2.67287076
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66763526
133spindle checkpoint (GO:0031577)2.65114458
134mRNA transport (GO:0051028)2.64687789
135cellular response to topologically incorrect protein (GO:0035967)2.64451904
136translational termination (GO:0006415)2.64210955
137DNA topological change (GO:0006265)2.63564754
138activation of Rac GTPase activity (GO:0032863)2.63081931
139tRNA aminoacylation for protein translation (GO:0006418)2.61545945
140RNA stabilization (GO:0043489)2.61504994
141mRNA stabilization (GO:0048255)2.61504994
142chromosome condensation (GO:0030261)2.61464906
143meiotic chromosome segregation (GO:0045132)2.61170561
144negative regulation of mRNA processing (GO:0050686)2.60790213
145negative regulation of mRNA metabolic process (GO:1903312)2.60248721
146telomere maintenance (GO:0000723)2.60102047
147ribosomal large subunit biogenesis (GO:0042273)2.59989075
148viral transcription (GO:0019083)2.59895981
149mitotic G1 DNA damage checkpoint (GO:0031571)2.59650107
150endodermal cell differentiation (GO:0035987)2.58461427
151protein targeting to plasma membrane (GO:0072661)2.57895452
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49736854
153spliceosomal tri-snRNP complex assembly (GO:0000244)2.49648637
154negative regulation of protein localization to plasma membrane (GO:1903077)2.48654801
155pinocytosis (GO:0006907)2.48627887
156tricarboxylic acid metabolic process (GO:0072350)2.47484480
157dicarboxylic acid biosynthetic process (GO:0043650)2.46776416
158endocytic recycling (GO:0032456)2.46696086
159negative regulation of fatty acid transport (GO:2000192)2.46038755
160positive regulation of receptor recycling (GO:0001921)2.45302600
161cellular copper ion homeostasis (GO:0006878)2.44749573
162protein localization to microtubule (GO:0035372)2.44133119
163vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.43802094
164regulation of mammary gland epithelial cell proliferation (GO:0033599)2.40567775
165positive regulation of endothelial cell apoptotic process (GO:2000353)2.40543615
166negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.40173233
167mammary gland epithelial cell proliferation (GO:0033598)2.40122252
168response to endoplasmic reticulum stress (GO:0034976)2.40092761
169regulation of glucose import in response to insulin stimulus (GO:2001273)2.39841235
170positive regulation of keratinocyte differentiation (GO:0045618)2.38068842
171embryo implantation (GO:0007566)2.37747377
172negative regulation of erythrocyte differentiation (GO:0045647)2.37621356
173positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.35611956
174regulation of NFAT protein import into nucleus (GO:0051532)2.35203882
175response to unfolded protein (GO:0006986)2.34686145
176apoptotic cell clearance (GO:0043277)2.32343282
177mesodermal cell differentiation (GO:0048333)2.29150968
178regulation of water loss via skin (GO:0033561)2.27818452
179branching involved in mammary gland duct morphogenesis (GO:0060444)2.27687919
180regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.27541155
181Golgi organization (GO:0007030)2.25993093
182negative regulation of necroptotic process (GO:0060546)2.25587760
183peptidyl-lysine dimethylation (GO:0018027)2.24793995
184actin filament bundle assembly (GO:0051017)2.24587150
185actin filament bundle organization (GO:0061572)2.24587150
186dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.24308352
187glucose catabolic process (GO:0006007)2.23939454
188substrate-dependent cell migration (GO:0006929)2.20318935
189insulin-like growth factor receptor signaling pathway (GO:0048009)2.18562511
1904-hydroxyproline metabolic process (GO:0019471)2.18316737
191embryonic process involved in female pregnancy (GO:0060136)2.18159738
192positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.17308944
193tricarboxylic acid cycle (GO:0006099)2.16562761
194negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.16444800
195adhesion of symbiont to host (GO:0044406)2.16003206
196regulation of protein localization to plasma membrane (GO:1903076)2.15813535
197response to topologically incorrect protein (GO:0035966)2.15601188
198peptidyl-asparagine modification (GO:0018196)2.13522618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.95007640
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.74464092
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.38596225
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98742497
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.91944007
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.60827974
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02536527
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.91913923
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.84990135
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.65242068
11ZNF263_19887448_ChIP-Seq_K562_Human2.62857351
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52693414
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.43954687
14AR_21909140_ChIP-Seq_LNCAP_Human2.40549067
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35163911
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30964003
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.22820237
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.16480551
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.15785142
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13250337
21MYC_22102868_ChIP-Seq_BL_Human2.10505268
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.08597549
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.05629621
24XRN2_22483619_ChIP-Seq_HELA_Human2.05627743
25RACK7_27058665_Chip-Seq_MCF-7_Human2.04730745
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03338505
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03011133
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.00979056
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99587707
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.99031585
31RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.95138051
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.92124955
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.90111834
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83228753
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.83036533
36* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.81938335
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81730438
38LXR_22292898_ChIP-Seq_THP-1_Human1.80622495
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.77147722
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.77029266
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76784352
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76690727
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76522251
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74344745
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.73379777
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72806744
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72327775
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71096671
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69965824
50* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.69658896
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68648298
52VDR_23849224_ChIP-Seq_CD4+_Human1.67492057
53SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.66966329
54SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.66966329
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66935798
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65074923
57DCP1A_22483619_ChIP-Seq_HELA_Human1.64949332
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64740066
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64209292
60FOXP3_21729870_ChIP-Seq_TREG_Human1.64046069
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60922222
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57425839
63ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.56591041
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55549742
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55203733
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54568459
67CIITA_25753668_ChIP-Seq_RAJI_Human1.52912004
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52049612
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51441169
70GABP_19822575_ChIP-Seq_HepG2_Human1.50204261
71ELK1_19687146_ChIP-ChIP_HELA_Human1.49009043
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48286583
73TTF2_22483619_ChIP-Seq_HELA_Human1.47807157
74TFEB_21752829_ChIP-Seq_HELA_Human1.45927170
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43488902
76KDM5A_27292631_Chip-Seq_BREAST_Human1.43060680
77TBX20_22328084_ChIP-Seq_HEART_Mouse1.42910324
78TBX20_22080862_ChIP-Seq_HEART_Mouse1.42910324
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42444637
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40688307
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39282825
82TCF7_22412390_ChIP-Seq_EML_Mouse1.38825746
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38803457
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38781874
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.37595287
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36009588
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35260117
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.34852581
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.33587168
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31212036
91TP53_22127205_ChIP-Seq_IMR90_Human1.26843356
92HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26069073
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.25963848
94KDM2B_26808549_Chip-Seq_DND41_Human1.25166952
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24861447
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22739274
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22160999
98* TET1_21451524_ChIP-Seq_MESCs_Mouse1.21803794
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21454496
100CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20581365
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20509730
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20151222
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.20140956
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.19546592
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19116749
106KDM2B_26808549_Chip-Seq_K562_Human1.18989917
107NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16394221
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15839287
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15742166
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15461908
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14767425
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14628323
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14065748
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12261178
115* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11501579
116RXR_22158963_ChIP-Seq_LIVER_Mouse1.11378059
117* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10990251
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10669987
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09824884
120VDR_21846776_ChIP-Seq_THP-1_Human1.09745565
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.07354753
122P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07211525
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06390304
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05909918
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.05219848
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03799501
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03346214
128SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01667584
129BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01038701
130RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00853817
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00470184
132* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99508748
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99404254
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98201482
135CLOCK_20551151_ChIP-Seq_293T_Human0.97767288
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96910291
137NCOR1_26117541_ChIP-Seq_K562_Human0.95368231
138CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.95146707
139PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95077832
140GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94346037
141GATA1_22025678_ChIP-Seq_K562_Human0.94115685
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93916221
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93911334
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93739687
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.93444911
146* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93285664
147* SRF_21415370_ChIP-Seq_HL-1_Mouse0.92795459
148CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92705091
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91519092
150ATF3_27146783_Chip-Seq_COLON_Human0.91240201
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.90746122
152KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90364453
153HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89844269
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89584625
155FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89490391
156* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89476932
157CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89470597
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88463363
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87847238
160CHD1_26751641_Chip-Seq_LNCaP_Human0.87514369
161SALL1_21062744_ChIP-ChIP_HESCs_Human0.85394744
162ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84792276
163SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84091889
164HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83920836
165GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83104177
166PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81758438
167* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81547402
168TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80929969
169TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80490606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.53559502
2MP0003693_abnormal_embryo_hatching3.42836999
3MP0003111_abnormal_nucleus_morphology3.33575787
4MP0004957_abnormal_blastocyst_morpholog3.30533279
5MP0003077_abnormal_cell_cycle3.11385119
6MP0010352_gastrointestinal_tract_polyps3.08901387
7MP0003705_abnormal_hypodermis_morpholog2.83704946
8MP0009780_abnormal_chondrocyte_physiolo2.58200727
9MP0008057_abnormal_DNA_replication2.56931421
10MP0010234_abnormal_vibrissa_follicle2.52461439
11MP0005451_abnormal_body_composition2.40152960
12MP0003123_paternal_imprinting2.39693437
13MP0005058_abnormal_lysosome_morphology2.37916521
14MP0006054_spinal_hemorrhage2.37314862
15MP0008007_abnormal_cellular_replicative2.37247228
16MP0009840_abnormal_foam_cell2.33337073
17MP0003191_abnormal_cellular_cholesterol2.31257580
18MP0002396_abnormal_hematopoietic_system2.22179229
19MP0010307_abnormal_tumor_latency2.16932031
20MP0003950_abnormal_plasma_membrane2.16092148
21MP0000751_myopathy2.15953808
22MP0003091_abnormal_cell_migration2.14610021
23MP0001730_embryonic_growth_arrest2.13338664
24MP0008058_abnormal_DNA_repair2.02592621
25MP0008260_abnormal_autophagy2.01607671
26MP0000350_abnormal_cell_proliferation2.01257170
27MP0005257_abnormal_intraocular_pressure1.98260181
28MP0000013_abnormal_adipose_tissue1.91494912
29MP0003806_abnormal_nucleotide_metabolis1.89312109
30MP0005076_abnormal_cell_differentiation1.86267695
31MP0008932_abnormal_embryonic_tissue1.79640386
32MP0004197_abnormal_fetal_growth/weight/1.76910850
33MP0004147_increased_porphyrin_level1.75954686
34MP0003656_abnormal_erythrocyte_physiolo1.73800900
35MP0001672_abnormal_embryogenesis/_devel1.71235966
36MP0005380_embryogenesis_phenotype1.71235966
37MP0000003_abnormal_adipose_tissue1.69346405
38MP0003453_abnormal_keratinocyte_physiol1.68776547
39MP0001697_abnormal_embryo_size1.67630135
40MP0003984_embryonic_growth_retardation1.67172895
41MP0000759_abnormal_skeletal_muscle1.65041376
42MP0002088_abnormal_embryonic_growth/wei1.64236652
43MP0010368_abnormal_lymphatic_system1.63600437
44MP0008438_abnormal_cutaneous_collagen1.61215963
45MP0002086_abnormal_extraembryonic_tissu1.57356053
46MP0000749_muscle_degeneration1.56586930
47MP0010030_abnormal_orbit_morphology1.55744720
48MP0001958_emphysema1.55070479
49MP0004808_abnormal_hematopoietic_stem1.54628823
50MP0002080_prenatal_lethality1.53936037
51MP0003567_abnormal_fetal_cardiomyocyte1.52151589
52MP0009053_abnormal_anal_canal1.51284288
53MP0005409_darkened_coat_color1.51188084
54MP0003566_abnormal_cell_adhesion1.49968710
55MP0002796_impaired_skin_barrier1.47817517
56MP0002877_abnormal_melanocyte_morpholog1.47240430
57MP0002084_abnormal_developmental_patter1.44483373
58MP0000490_abnormal_crypts_of1.39732326
59MP0002085_abnormal_embryonic_tissue1.38228380
60MP0005397_hematopoietic_system_phenotyp1.37572463
61MP0001545_abnormal_hematopoietic_system1.37572463
62MP0004087_abnormal_muscle_fiber1.37175899
63MP0005023_abnormal_wound_healing1.33003109
64MP0002896_abnormal_bone_mineralization1.32537504
65MP0004510_myositis1.32464125
66MP0000747_muscle_weakness1.32111968
67MP0005330_cardiomyopathy1.26003368
68MP0001915_intracranial_hemorrhage1.24493098
69MP0003121_genomic_imprinting1.20384941
70MP0003329_amyloid_beta_deposits1.20258895
71MP0002019_abnormal_tumor_incidence1.19174114
72MP0000313_abnormal_cell_death1.18107483
73MP0000537_abnormal_urethra_morphology1.15617673
74MP0001661_extended_life_span1.15161004
75MP0005165_increased_susceptibility_to1.14344558
76MP0004858_abnormal_nervous_system1.13698105
77MP0004185_abnormal_adipocyte_glucose1.12746858
78MP0002332_abnormal_exercise_endurance1.12668519
79MP0005375_adipose_tissue_phenotype1.09438327
80MP0001216_abnormal_epidermal_layer1.08233434
81MP0000762_abnormal_tongue_morphology1.06653704
82MP0001542_abnormal_bone_strength1.06301912
83MP0005360_urolithiasis1.05465527
84MP0001293_anophthalmia1.05071453
85MP0000733_abnormal_muscle_development1.04371891
86MP0000767_abnormal_smooth_muscle1.04208774
87MP0000467_abnormal_esophagus_morphology1.03968378
88MP0003890_abnormal_embryonic-extraembry1.00893484
89MP0004947_skin_inflammation1.00059716
90MP0000678_abnormal_parathyroid_gland0.99873145
91MP0009672_abnormal_birth_weight0.97429892
92MP0003786_premature_aging0.96630618
93MP0004036_abnormal_muscle_relaxation0.95869945
94MP0006138_congestive_heart_failure0.93705906
95MP0009333_abnormal_splenocyte_physiolog0.92838779
96MP0005275_abnormal_skin_tensile0.91505457
97MP0004264_abnormal_extraembryonic_tissu0.91192960
98MP0009278_abnormal_bone_marrow0.90698221
99MP0003868_abnormal_feces_composition0.90225740
100MP0004782_abnormal_surfactant_physiolog0.90060319
101MP0009384_cardiac_valve_regurgitation0.89198260
102MP0000428_abnormal_craniofacial_morphol0.88758992
103MP0001243_abnormal_dermal_layer0.88538819
104MP0001849_ear_inflammation0.88395075
105MP0000579_abnormal_nail_morphology0.87932639
106MP0000703_abnormal_thymus_morphology0.87413537
107MP0003279_aneurysm0.86329411
108MP0000358_abnormal_cell_content/0.86157073
109MP0004233_abnormal_muscle_weight0.85745728
110MP0000627_abnormal_mammary_gland0.85089963
111MP0002111_abnormal_tail_morphology0.85010604
112MP0003828_pulmonary_edema0.83085711
113MP0000858_altered_metastatic_potential0.82129407
114MP0009703_decreased_birth_body0.80025102
115MP0005666_abnormal_adipose_tissue0.79062715
116MP0005503_abnormal_tendon_morphology0.78341334
117MP0003186_abnormal_redox_activity0.78304824
118MP0005384_cellular_phenotype0.78003379
119MP0002697_abnormal_eye_size0.77718682
120MP0002722_abnormal_immune_system0.77318590
121MP0002398_abnormal_bone_marrow0.77130069
122MP0005621_abnormal_cell_physiology0.77121103
123MP0003075_altered_response_to0.76866771
124MP0000598_abnormal_liver_morphology0.76704965
125MP0002925_abnormal_cardiovascular_devel0.76440666
126MP0005508_abnormal_skeleton_morphology0.75632534
127MP0003172_abnormal_lysosome_physiology0.75406332
128MP0003115_abnormal_respiratory_system0.75155684
129MP0003959_abnormal_lean_body0.74726144
130MP0010630_abnormal_cardiac_muscle0.74145744
131MP0000266_abnormal_heart_morphology0.73653593
132MP0001881_abnormal_mammary_gland0.72577900
133MP0010771_integument_phenotype0.72145284
134MP0000604_amyloidosis0.71887247
135MP0003221_abnormal_cardiomyocyte_apopto0.71719497
136MP0002092_abnormal_eye_morphology0.71638094
137MP0001299_abnormal_eye_distance/0.71203432
138MP0001348_abnormal_lacrimal_gland0.68890769
139MP0005501_abnormal_skin_physiology0.68606500
140MP0000689_abnormal_spleen_morphology0.68173649
141MP0002269_muscular_atrophy0.67677330
142MP0009931_abnormal_skin_appearance0.67537327
143MP0000750_abnormal_muscle_regeneration0.66843813
144MP0003283_abnormal_digestive_organ0.66693666
145MP0003119_abnormal_digestive_system0.66147884
146MP0003942_abnormal_urinary_system0.66116116
147MP0004084_abnormal_cardiac_muscle0.65213175
148MP0003941_abnormal_skin_development0.63686551
149MP0005623_abnormal_meninges_morphology0.63607468
150MP0000477_abnormal_intestine_morphology0.63540698
151MP0004272_abnormal_basement_membrane0.63033531
152MP0002060_abnormal_skin_morphology0.63028963
153MP0008877_abnormal_DNA_methylation0.62894550
154MP0003448_altered_tumor_morphology0.62181052
155MP0003300_gastrointestinal_ulcer0.62149234
156MP0002295_abnormal_pulmonary_circulatio0.62108265
157MP0004134_abnormal_chest_morphology0.61220442
158MP0002108_abnormal_muscle_morphology0.60939185
159MP0000462_abnormal_digestive_system0.60835233
160MP0003943_abnormal_hepatobiliary_system0.60212605
161MP0008770_decreased_survivor_rate0.59995986
162MP0002106_abnormal_muscle_physiology0.59801785
163MP0003763_abnormal_thymus_physiology0.59477083
164MP0000377_abnormal_hair_follicle0.58562291
165MP0002429_abnormal_blood_cell0.58551402
166MP0000343_altered_response_to0.57744227
167MP0002932_abnormal_joint_morphology0.56325982

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.43141182
2Selective tooth agenesis (HP:0001592)3.57641626
3Vertebral compression fractures (HP:0002953)3.52561546
4Spinal rigidity (HP:0003306)3.40602102
5Distal lower limb amyotrophy (HP:0008944)3.26621288
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.24751208
7Birth length less than 3rd percentile (HP:0003561)3.14314251
8Ependymoma (HP:0002888)3.12854251
9Atrophic scars (HP:0001075)3.11543287
10Distal lower limb muscle weakness (HP:0009053)3.04900358
11Protrusio acetabuli (HP:0003179)3.02519672
12Centrally nucleated skeletal muscle fibers (HP:0003687)2.98814399
13Distal upper limb amyotrophy (HP:0007149)2.96084957
14Upper limb amyotrophy (HP:0009129)2.96084957
15Short nail (HP:0001799)2.85586133
16Colon cancer (HP:0003003)2.83930311
17Medulloblastoma (HP:0002885)2.83275332
18Short 4th metacarpal (HP:0010044)2.82825937
19Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.82825937
20Osteolytic defects of the phalanges of the hand (HP:0009771)2.78187555
21Osteolytic defects of the hand bones (HP:0009699)2.78187555
22Type 1 muscle fiber predominance (HP:0003803)2.71221382
23Achilles tendon contracture (HP:0001771)2.68000419
24Increased variability in muscle fiber diameter (HP:0003557)2.64207315
25Abnormality of skeletal muscle fiber size (HP:0012084)2.64100923
26Broad face (HP:0000283)2.63003306
27Deviation of the thumb (HP:0009603)2.62421460
28Reticulocytopenia (HP:0001896)2.61682704
29Abnormality of the anterior horn cell (HP:0006802)2.61405802
30Degeneration of anterior horn cells (HP:0002398)2.61405802
31Mildly elevated creatine phosphokinase (HP:0008180)2.55615505
32Fragile skin (HP:0001030)2.52550676
33Abnormality of the Achilles tendon (HP:0005109)2.49455967
34Increased nuchal translucency (HP:0010880)2.48509605
35Hand muscle atrophy (HP:0009130)2.47163249
36Wormian bones (HP:0002645)2.46124109
37Proximal placement of thumb (HP:0009623)2.45118334
38Cervical subluxation (HP:0003308)2.37836228
39Ankle contracture (HP:0006466)2.34397947
40Abnormality of reticulocytes (HP:0004312)2.34052171
41Abnormality of the calcaneus (HP:0008364)2.33815890
42Exercise-induced myalgia (HP:0003738)2.33794697
43High pitched voice (HP:0001620)2.30861232
44Abnormality of cells of the erythroid lineage (HP:0012130)2.30625536
45Generalized amyotrophy (HP:0003700)2.29266571
46Chromsome breakage (HP:0040012)2.28948422
47Lower limb amyotrophy (HP:0007210)2.28921214
48Metaphyseal cupping (HP:0003021)2.27038361
49Astrocytoma (HP:0009592)2.26909384
50Abnormality of the astrocytes (HP:0100707)2.26909384
51Abnormal number of erythroid precursors (HP:0012131)2.26363212
52Rhabdomyosarcoma (HP:0002859)2.25780293
53Hyperacusis (HP:0010780)2.24910748
54Mitral stenosis (HP:0001718)2.23984198
55Volvulus (HP:0002580)2.23902338
56Aplastic anemia (HP:0001915)2.23162531
57Difficulty climbing stairs (HP:0003551)2.22485742
58Progressive muscle weakness (HP:0003323)2.21831177
59Basal cell carcinoma (HP:0002671)2.19850412
60Thrombocytosis (HP:0001894)2.18583448
61Reticulocytosis (HP:0001923)2.18509996
62Reduced subcutaneous adipose tissue (HP:0003758)2.18051813
63Poikilocytosis (HP:0004447)2.17572672
64Asymmetric septal hypertrophy (HP:0001670)2.17102000
65Vascular tortuosity (HP:0004948)2.16669329
66Abnormality of the 4th metacarpal (HP:0010012)2.16513890
67Multiple enchondromatosis (HP:0005701)2.15908165
68Interstitial pulmonary disease (HP:0006530)2.13360619
69Arterial tortuosity (HP:0005116)2.12048373
70Oral leukoplakia (HP:0002745)2.11990136
71Missing ribs (HP:0000921)2.11725651
72Abnormality of chromosome stability (HP:0003220)2.11489784
73Myelodysplasia (HP:0002863)2.09050175
74Ectopic kidney (HP:0000086)2.08934134
75Cerebral aneurysm (HP:0004944)2.08242270
76Elbow flexion contracture (HP:0002987)2.07644403
77Broad palm (HP:0001169)2.07007646
78Back pain (HP:0003418)2.06707126
79Aortic aneurysm (HP:0004942)2.06005501
80Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05997790
8111 pairs of ribs (HP:0000878)2.04250832
82Flat acetabular roof (HP:0003180)2.01637724
83Aortic dissection (HP:0002647)2.01268080
84Abnormality of liposaccharide metabolism (HP:0010968)2.01138152
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.01138152
86Abnormality of glycolipid metabolism (HP:0010969)2.01138152
87Glioma (HP:0009733)2.00915724
88Nemaline bodies (HP:0003798)2.00912408
89Entropion (HP:0000621)1.99806572
90Abnormal number of incisors (HP:0011064)1.99716740
91Right ventricular cardiomyopathy (HP:0011663)1.99118186
92Ragged-red muscle fibers (HP:0003200)1.99047207
93Amaurosis fugax (HP:0100576)1.96594409
94Muscle fiber inclusion bodies (HP:0100299)1.96526287
95Neoplasm of striated muscle (HP:0009728)1.94852454
96Ulnar bowing (HP:0003031)1.93649246
97J-shaped sella turcica (HP:0002680)1.93130609
98Cutaneous melanoma (HP:0012056)1.92672583
99Hyporeflexia of lower limbs (HP:0002600)1.92584257
100Slender long bone (HP:0003100)1.91997123
101Chromosomal breakage induced by crosslinking agents (HP:0003221)1.91342510
102Blue sclerae (HP:0000592)1.91213253
103Breast hypoplasia (HP:0003187)1.90828821
104Spastic diplegia (HP:0001264)1.90637794
105Thin bony cortex (HP:0002753)1.90123617
106Atresia of the external auditory canal (HP:0000413)1.90078070
107Spondylolisthesis (HP:0003302)1.89989330
108Prominent nose (HP:0000448)1.89520330
109Freckling (HP:0001480)1.89403877
110Dilatation of the ascending aorta (HP:0005111)1.89303300
111Small intestinal stenosis (HP:0012848)1.89226706
112Duodenal stenosis (HP:0100867)1.89226706
113Neoplasm of the pancreas (HP:0002894)1.88652963
114Abnormal gallbladder physiology (HP:0012438)1.88289159
115Cholecystitis (HP:0001082)1.88289159
116Upper limb muscle weakness (HP:0003484)1.88062946
117Short 5th finger (HP:0009237)1.87371656
118Dysostosis multiplex (HP:0000943)1.86950627
119Mitral regurgitation (HP:0001653)1.86629905
120Abnormality of dentin (HP:0010299)1.85794550
121Scapular winging (HP:0003691)1.85048659
122Abnormality of the distal phalanges of the toes (HP:0010182)1.84926763
123Cafe-au-lait spot (HP:0000957)1.84876563
124Patellar aplasia (HP:0006443)1.84791699
125Long eyelashes (HP:0000527)1.84762344
126Abnormality of oral frenula (HP:0000190)1.84214103
127Increased density of long bones (HP:0006392)1.84099122
128Rhabdomyolysis (HP:0003201)1.83951125
129Ankyloglossia (HP:0010296)1.83894315
130Squamous cell carcinoma (HP:0002860)1.83296142
131Agnosia (HP:0010524)1.83101448
132Natal tooth (HP:0000695)1.83060629
133Cerebral inclusion bodies (HP:0100314)1.82983403
134Aneurysm (HP:0002617)1.82941337
135Urinary glycosaminoglycan excretion (HP:0003541)1.82879315
136Mucopolysacchariduria (HP:0008155)1.82879315
137Hammertoe (HP:0001765)1.82820191
138EMG: myopathic abnormalities (HP:0003458)1.79693955
139Glucose intolerance (HP:0000833)1.79430516
140Renal duplication (HP:0000075)1.78613708
141Short middle phalanx of the 5th finger (HP:0004220)1.77904106
142Round ear (HP:0100830)1.77114983
143Adenoma sebaceum (HP:0009720)1.76871708
144Angiofibromas (HP:0010615)1.76871708
145Increased connective tissue (HP:0009025)1.76422440
146Hyperparathyroidism (HP:0000843)1.75435517
147Advanced eruption of teeth (HP:0006288)1.75361253
148Ovarian neoplasm (HP:0100615)1.75011440
149Bladder diverticulum (HP:0000015)1.74747257
150Broad thumb (HP:0011304)1.73134527
151Dysmetric saccades (HP:0000641)1.72947799
152Follicular hyperkeratosis (HP:0007502)1.72594799
153Bundle branch block (HP:0011710)1.72460498
154Neoplasm of the oral cavity (HP:0100649)1.72106308
155Abnormal lung lobation (HP:0002101)1.71657292
156Skin tags (HP:0010609)1.71056673
157Abnormality of the tricuspid valve (HP:0001702)1.70944605
158Intestinal polyp (HP:0005266)1.70637732
159Meckel diverticulum (HP:0002245)1.70498731
160Mesomelia (HP:0003027)1.70418796
161Aplasia/Hypoplasia of the patella (HP:0006498)1.70175551
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.69478283
163Abnormality of polysaccharide metabolism (HP:0011012)1.69478283
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.69478283
165Abnormality of the duodenum (HP:0002246)1.68710374
166Trismus (HP:0000211)1.68351695
167Bowel diverticulosis (HP:0005222)1.67854373
168Cardiovascular calcification (HP:0011915)1.67009603
169Biliary tract neoplasm (HP:0100574)1.66883995
170Hypokinesia (HP:0002375)1.66641392
171Spinal cord compression (HP:0002176)1.66314922
172Neck muscle weakness (HP:0000467)1.66109723
173Muscle stiffness (HP:0003552)1.65834705
174Foot dorsiflexor weakness (HP:0009027)1.65168800
175Gastrointestinal carcinoma (HP:0002672)1.64139777
176Malignant gastrointestinal tract tumors (HP:0006749)1.64139777
177Long toe (HP:0010511)1.64111056
178Neoplasm of the colon (HP:0100273)1.63643699
179Intestinal polyposis (HP:0200008)1.62952644
180Deep philtrum (HP:0002002)1.61937713
181Abnormality of the ileum (HP:0001549)1.61544876
182Impulsivity (HP:0100710)1.61505130
183Abnormality of the acetabulum (HP:0003170)1.61475031
184Preauricular skin tag (HP:0000384)1.61293840
185Overlapping toe (HP:0001845)1.60474364
186Shallow orbits (HP:0000586)1.60046709
187Abnormality of pyrimidine metabolism (HP:0004353)1.59238826
188Abnormality of the peritoneum (HP:0002585)1.59144351
189Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.58344563
190Broad phalanges of the hand (HP:0009768)1.58269243
191Pallor (HP:0000980)1.57278928
192Carpal bone hypoplasia (HP:0001498)1.57007378
193Nonimmune hydrops fetalis (HP:0001790)1.56034758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.86772130
2EEF2K2.91436825
3EIF2AK12.86089545
4PKN22.76584421
5NEK12.76550936
6WEE12.71737390
7IRAK32.64906395
8PRPF4B2.64443862
9CDK122.64374440
10BUB12.56814572
11ICK2.45617553
12NEK22.40001211
13TRIB32.31431047
14PASK2.29878274
15MST1R2.14370074
16ACVR1B2.11074032
17SMG12.08270603
18TTK1.98368373
19RPS6KB21.95479777
20SCYL21.89326324
21TSSK61.85400470
22NTRK11.83829925
23RPS6KA41.80385732
24TGFBR11.78936812
25MAP3K101.75558306
26BRSK21.74411931
27STK101.70195380
28TTN1.67622934
29FLT31.66123524
30ARAF1.61201426
31ATR1.57472941
32MAP3K81.49222684
33CDK41.48237021
34AURKB1.48123779
35PLK11.45990756
36CDK71.45850535
37SRPK11.44909598
38PRKD31.43173370
39LMTK21.41275343
40NME21.38586898
41MYLK1.37814042
42LIMK11.31703505
43KSR21.26785431
44LRRK21.23807101
45STK381.23603153
46CDK61.21315924
47MKNK11.20748144
48MAP2K31.20715595
49PLK31.19527616
50EPHA21.16432663
51CHEK11.15299882
52STK41.13466604
53EPHB11.13370046
54MOS1.12595332
55BRD41.12060890
56STK31.10632658
57LATS11.08244011
58PAK41.06958749
59MAP3K131.01341215
60PIM11.00976028
61BRSK10.99182879
62MTOR0.96538505
63PLK40.95191677
64TESK20.93998623
65PTK60.92389575
66PDGFRA0.91787153
67ATM0.90327415
68CHEK20.88209288
69ALK0.87417559
70DYRK30.85258133
71PAK20.84599121
72FGFR40.83879842
73PAK60.82007373
74AKT30.81436598
75EIF2AK30.80468695
76BRAF0.79673879
77PRKD20.79447185
78CDK20.77914405
79TLK10.77785015
80VRK10.77589447
81KDR0.77088121
82AURKA0.75437743
83NEK90.74668357
84RPS6KA20.74197828
85TBK10.73959541
86FGFR10.73004756
87PHKG10.71982716
88PHKG20.71982716
89MAP3K10.71284941
90MELK0.69160878
91MAPK110.68493123
92CDK90.64824110
93CDC42BPA0.64355376
94ZAK0.63961419
95BCKDK0.63245522
96PBK0.62937346
97PDPK10.62614158
98MAP3K140.59988293
99TESK10.59822607
100JAK30.58802865
101MAP3K20.58317432
102MAP3K30.58248851
103SIK10.55899890
104CDK10.55509041
105NEK60.55149196
106MAP3K90.53757315
107PIM20.53669608
108MAP3K120.52540947
109CSNK2A20.52175282
110MAPKAPK30.52025378
111MAP3K60.51966656
112CLK10.50785163
113RAF10.50489934
114MAP4K10.50464000
115TAOK20.50096245
116PDGFRB0.50005508
117ILK0.48985154
118AKT20.48167052
119CAMK1G0.48054106
120CDK80.47474308
121BMX0.46386888
122ERN10.46092071
123CHUK0.44751972
124DDR20.44409813
125ZAP700.44355194
126STK38L0.43645897
127RET0.42918894
128SGK30.42876091
129CAMK2G0.42450692
130MAP2K10.42016500
131PRKDC0.41685847
132DMPK0.40929429
133MAP3K110.40657124
134MARK20.40458602
135KSR10.39699127
136PAK10.39536505
137ERBB40.38760942
138LATS20.38599738
139CSNK2A10.38458778
140ROCK20.37931705
141RIPK10.37188084
142DAPK30.36707209
143PDK40.35597857
144PDK30.35597857
145DAPK10.35059433
146CAMK1D0.35026727
147TGFBR20.34315283
148EPHB20.34295451
149MAPKAPK20.33066136
150MKNK20.32705831
151AKT10.32250222
152RPS6KB10.30526970
153TRPM70.30404444
154PTK20.30316811
155MET0.29591008

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.48771739
2Mismatch repair_Homo sapiens_hsa034303.58535979
3One carbon pool by folate_Homo sapiens_hsa006703.42747088
4Other glycan degradation_Homo sapiens_hsa005113.13540021
5RNA transport_Homo sapiens_hsa030133.03795089
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03021981
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.94707398
8Cell cycle_Homo sapiens_hsa041102.76281346
9Spliceosome_Homo sapiens_hsa030402.72979444
10Base excision repair_Homo sapiens_hsa034102.58955379
11Nucleotide excision repair_Homo sapiens_hsa034202.47387044
12Glycosaminoglycan degradation_Homo sapiens_hsa005312.27576190
13Homologous recombination_Homo sapiens_hsa034402.11287242
14Ribosome_Homo sapiens_hsa030102.00510948
15Non-homologous end-joining_Homo sapiens_hsa034501.83559735
16Pyrimidine metabolism_Homo sapiens_hsa002401.76153860
17Proteasome_Homo sapiens_hsa030501.71780759
18RNA polymerase_Homo sapiens_hsa030201.70625917
19RNA degradation_Homo sapiens_hsa030181.60101382
20p53 signaling pathway_Homo sapiens_hsa041151.58818854
21Selenocompound metabolism_Homo sapiens_hsa004501.58216478
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58135918
23mRNA surveillance pathway_Homo sapiens_hsa030151.57801449
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56696804
25Systemic lupus erythematosus_Homo sapiens_hsa053221.55731898
26Fanconi anemia pathway_Homo sapiens_hsa034601.51562685
27Prion diseases_Homo sapiens_hsa050201.50087832
28Vibrio cholerae infection_Homo sapiens_hsa051101.47195823
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44993118
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39598510
31Viral carcinogenesis_Homo sapiens_hsa052031.34137186
32Biosynthesis of amino acids_Homo sapiens_hsa012301.34083474
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33470053
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31416454
35Dilated cardiomyopathy_Homo sapiens_hsa054141.24757510
36Glioma_Homo sapiens_hsa052141.22014819
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17862653
38Insulin signaling pathway_Homo sapiens_hsa049101.17693073
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.13712180
40Small cell lung cancer_Homo sapiens_hsa052221.13457031
41Amoebiasis_Homo sapiens_hsa051461.12411287
42VEGF signaling pathway_Homo sapiens_hsa043701.12270613
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12198048
44Lysosome_Homo sapiens_hsa041421.08493772
45Carbon metabolism_Homo sapiens_hsa012001.07005281
46ErbB signaling pathway_Homo sapiens_hsa040121.06038664
47Basal transcription factors_Homo sapiens_hsa030221.02811908
48Antigen processing and presentation_Homo sapiens_hsa046121.02517034
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02038112
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.01373582
51Renal cell carcinoma_Homo sapiens_hsa052110.99925593
52Epstein-Barr virus infection_Homo sapiens_hsa051690.98873737
53Herpes simplex infection_Homo sapiens_hsa051680.97493693
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.97383698
55Inositol phosphate metabolism_Homo sapiens_hsa005620.97123028
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95909361
57Legionellosis_Homo sapiens_hsa051340.95654703
58HTLV-I infection_Homo sapiens_hsa051660.95476191
59MicroRNAs in cancer_Homo sapiens_hsa052060.94873767
60Thyroid cancer_Homo sapiens_hsa052160.94442127
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93904753
62Chronic myeloid leukemia_Homo sapiens_hsa052200.93470747
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92723806
64Endocytosis_Homo sapiens_hsa041440.91856980
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91247087
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90502161
67Lysine degradation_Homo sapiens_hsa003100.88098207
68Sulfur metabolism_Homo sapiens_hsa009200.86509647
69Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85903523
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.85299045
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.85241185
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84695078
73Arginine biosynthesis_Homo sapiens_hsa002200.83063530
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79891878
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79186226
76Pentose phosphate pathway_Homo sapiens_hsa000300.78458241
77Phenylalanine metabolism_Homo sapiens_hsa003600.77805350
78Bladder cancer_Homo sapiens_hsa052190.75842661
79Fatty acid elongation_Homo sapiens_hsa000620.73292598
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73091857
81Hepatitis C_Homo sapiens_hsa051600.72899360
82Sphingolipid metabolism_Homo sapiens_hsa006000.72361608
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.71478215
84Circadian rhythm_Homo sapiens_hsa047100.71094725
85Purine metabolism_Homo sapiens_hsa002300.69547294
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.69394492
87Viral myocarditis_Homo sapiens_hsa054160.68070670
88Apoptosis_Homo sapiens_hsa042100.67198206
89Glucagon signaling pathway_Homo sapiens_hsa049220.66338460
90Prolactin signaling pathway_Homo sapiens_hsa049170.65669342
91Estrogen signaling pathway_Homo sapiens_hsa049150.64627702
92TNF signaling pathway_Homo sapiens_hsa046680.64319645
93TGF-beta signaling pathway_Homo sapiens_hsa043500.64161119
94Salmonella infection_Homo sapiens_hsa051320.63620914
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63470463
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63423771
97Adherens junction_Homo sapiens_hsa045200.62407227
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.61840378
99Fatty acid biosynthesis_Homo sapiens_hsa000610.61156275
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60153235
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59751590
102GnRH signaling pathway_Homo sapiens_hsa049120.59684139
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59365421
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58499594
105Basal cell carcinoma_Homo sapiens_hsa052170.57314557
106Oocyte meiosis_Homo sapiens_hsa041140.57012530
107Colorectal cancer_Homo sapiens_hsa052100.56179608
108Hippo signaling pathway_Homo sapiens_hsa043900.56018847
109Proteoglycans in cancer_Homo sapiens_hsa052050.55645896
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.55616696
111Hepatitis B_Homo sapiens_hsa051610.55466960
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52233559
113N-Glycan biosynthesis_Homo sapiens_hsa005100.51801340
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50341127
115mTOR signaling pathway_Homo sapiens_hsa041500.49757395
116Synaptic vesicle cycle_Homo sapiens_hsa047210.49002608
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.47890769
118Pyruvate metabolism_Homo sapiens_hsa006200.47748883
119Galactose metabolism_Homo sapiens_hsa000520.47443284
120Measles_Homo sapiens_hsa051620.46815548
121ECM-receptor interaction_Homo sapiens_hsa045120.44792152
122Melanoma_Homo sapiens_hsa052180.44764195
123Sulfur relay system_Homo sapiens_hsa041220.44357769
124Notch signaling pathway_Homo sapiens_hsa043300.44179265
125Arginine and proline metabolism_Homo sapiens_hsa003300.43939684
126Acute myeloid leukemia_Homo sapiens_hsa052210.43876720
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.43857232
128HIF-1 signaling pathway_Homo sapiens_hsa040660.43434247
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42521510
130Long-term potentiation_Homo sapiens_hsa047200.42341901
131Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41826124
132Pancreatic cancer_Homo sapiens_hsa052120.39904461
133Glutathione metabolism_Homo sapiens_hsa004800.39480243
134Non-small cell lung cancer_Homo sapiens_hsa052230.38304265
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37821450
136Focal adhesion_Homo sapiens_hsa045100.37620691
137Alcoholism_Homo sapiens_hsa050340.37523591
138Folate biosynthesis_Homo sapiens_hsa007900.37167783
139Fatty acid degradation_Homo sapiens_hsa000710.35772561
140Shigellosis_Homo sapiens_hsa051310.34988225
141Influenza A_Homo sapiens_hsa051640.33023983
142Prostate cancer_Homo sapiens_hsa052150.32735239
143Pathways in cancer_Homo sapiens_hsa052000.32046447
144NF-kappa B signaling pathway_Homo sapiens_hsa040640.31618401
145Endometrial cancer_Homo sapiens_hsa052130.29250512
146Toxoplasmosis_Homo sapiens_hsa051450.28862845
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28576189
148AMPK signaling pathway_Homo sapiens_hsa041520.26594912
149Insulin resistance_Homo sapiens_hsa049310.25656295
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25652550
151Fructose and mannose metabolism_Homo sapiens_hsa000510.25354315
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25039538

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »