PITX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.47920844
2paraxial mesoderm development (GO:0048339)6.40366246
3ribosomal small subunit biogenesis (GO:0042274)5.48467022
4polarized epithelial cell differentiation (GO:0030859)4.81059968
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.79362289
6lung morphogenesis (GO:0060425)4.67299782
7negative regulation of DNA repair (GO:0045738)4.66964189
8outer ear morphogenesis (GO:0042473)4.63547178
9lung-associated mesenchyme development (GO:0060484)4.50821299
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.39038828
11keratinization (GO:0031424)4.33015124
12peptide cross-linking (GO:0018149)4.22225852
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.13702460
14regulation of cardioblast proliferation (GO:0003264)3.97105788
15regulation of secondary heart field cardioblast proliferation (GO:0003266)3.97105788
16middle ear morphogenesis (GO:0042474)3.95995138
17keratinocyte differentiation (GO:0030216)3.94221024
18hippo signaling (GO:0035329)3.88426143
19establishment of apical/basal cell polarity (GO:0035089)3.85827006
20mammary gland epithelial cell differentiation (GO:0060644)3.83190831
21regulation of apoptotic process involved in morphogenesis (GO:1902337)3.83050358
22proximal/distal pattern formation (GO:0009954)3.81426028
23regulation of mammary gland epithelial cell proliferation (GO:0033599)3.79736852
24negative regulation of T cell differentiation in thymus (GO:0033085)3.77217902
25embryonic skeletal joint morphogenesis (GO:0060272)3.71689128
26pharyngeal system development (GO:0060037)3.66725605
27regulation of heart morphogenesis (GO:2000826)3.63042806
28thyroid gland development (GO:0030878)3.60532445
29DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.60064006
30negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.57401056
31morphogenesis of embryonic epithelium (GO:0016331)3.54114168
32embryonic foregut morphogenesis (GO:0048617)3.52171106
33regulation of translational termination (GO:0006449)3.50164017
34regulation of translational fidelity (GO:0006450)3.48575176
35ribonucleoprotein complex biogenesis (GO:0022613)3.44404744
36cochlea morphogenesis (GO:0090103)3.43180734
37mesenchyme development (GO:0060485)3.42947111
38translational elongation (GO:0006414)3.41356240
39protein localization to kinetochore (GO:0034501)3.37463832
40mesenchymal cell proliferation (GO:0010463)3.35790450
41bone trabecula formation (GO:0060346)3.34824741
42establishment of monopolar cell polarity (GO:0061162)3.32272184
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.32272184
44eyelid development in camera-type eye (GO:0061029)3.31821701
45G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.30177847
46embryonic cranial skeleton morphogenesis (GO:0048701)3.27702233
47maturation of SSU-rRNA (GO:0030490)3.26691227
48establishment of skin barrier (GO:0061436)3.26562487
49mitotic metaphase plate congression (GO:0007080)3.26431200
50regulation of cell proliferation involved in kidney development (GO:1901722)3.26013538
51DNA damage response, signal transduction resulting in transcription (GO:0042772)3.25101116
52tooth mineralization (GO:0034505)3.20425395
53protein localization to chromosome, centromeric region (GO:0071459)3.19888970
54epidermal cell differentiation (GO:0009913)3.19484463
55Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17737950
56ribosome biogenesis (GO:0042254)3.15225760
57DNA unwinding involved in DNA replication (GO:0006268)3.12978416
58regulation of water loss via skin (GO:0033561)3.10468325
59ribosomal small subunit assembly (GO:0000028)3.09161711
60cranial suture morphogenesis (GO:0060363)3.08024793
61outflow tract septum morphogenesis (GO:0003148)3.06416965
62regulation of G0 to G1 transition (GO:0070316)3.04417602
63embryonic forelimb morphogenesis (GO:0035115)3.02395201
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01813733
65regulation of chromatin binding (GO:0035561)3.01539254
66epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.00499023
67regulation of establishment of planar polarity (GO:0090175)3.00220380
68establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.99645717
69non-canonical Wnt signaling pathway (GO:0035567)2.99603783
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98165140
71cranial nerve morphogenesis (GO:0021602)2.95755573
72intestinal epithelial cell development (GO:0060576)2.95474343
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.93349631
74renal system development (GO:0072001)2.93342777
75viral life cycle (GO:0019058)2.93272243
76positive regulation of transcription regulatory region DNA binding (GO:2000679)2.93214945
77diaphragm development (GO:0060539)2.92963603
78notochord development (GO:0030903)2.92297546
79organ induction (GO:0001759)2.92239005
80cell differentiation involved in embryonic placenta development (GO:0060706)2.91998591
81chondrocyte proliferation (GO:0035988)2.90760747
82pseudouridine synthesis (GO:0001522)2.90294389
83heterochromatin organization (GO:0070828)2.89366726
84forelimb morphogenesis (GO:0035136)2.88935031
85protein targeting to ER (GO:0045047)2.86988688
86* hindlimb morphogenesis (GO:0035137)2.86589092
87regulation of glucocorticoid metabolic process (GO:0031943)2.86102114
88replicative senescence (GO:0090399)2.85676578
89atrioventricular valve morphogenesis (GO:0003181)2.84082156
90viral transcription (GO:0019083)2.84049409
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.83786820
92ribosome assembly (GO:0042255)2.83048844
93cotranslational protein targeting to membrane (GO:0006613)2.82687294
94translational termination (GO:0006415)2.80880180
95mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.80759160
96respiratory tube development (GO:0030323)2.80731330
97negative regulation of mRNA processing (GO:0050686)2.80135006
98negative regulation of cell fate specification (GO:0009996)2.80097882
99positive regulation of gastrulation (GO:2000543)2.79642783
100odontogenesis (GO:0042476)2.77843142
101cellular component biogenesis (GO:0044085)2.77583461
102DNA deamination (GO:0045006)2.76721637
103craniofacial suture morphogenesis (GO:0097094)2.76671045
104regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.76575174
105tRNA methylation (GO:0030488)2.76567012
106ncRNA 3-end processing (GO:0043628)2.75865948
107* embryonic hindlimb morphogenesis (GO:0035116)2.75145903
108cartilage morphogenesis (GO:0060536)2.74886511
109cell migration involved in heart development (GO:0060973)2.74501342
110cell surface receptor signaling pathway involved in heart development (GO:0061311)2.74351405
111negative regulation of kidney development (GO:0090185)2.73252997
112regulation of organ formation (GO:0003156)2.72875715
113odontogenesis of dentin-containing tooth (GO:0042475)2.72391198
114convergent extension (GO:0060026)2.71831393
115establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71480988
116DNA replication checkpoint (GO:0000076)2.71334050
117embryonic skeletal system morphogenesis (GO:0048704)2.70077974
118cellular protein complex disassembly (GO:0043624)2.69931530
119peptidyl-arginine methylation (GO:0018216)2.69178713
120peptidyl-arginine N-methylation (GO:0035246)2.69178713
121protein localization to endoplasmic reticulum (GO:0070972)2.68498642
122rRNA processing (GO:0006364)2.68077227
123hemidesmosome assembly (GO:0031581)2.67996844
124regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.67145115
125translational initiation (GO:0006413)2.67081244
126regulation of mesenchymal cell apoptotic process (GO:2001053)2.67061888
127regulation of glomerulus development (GO:0090192)2.67023812
128establishment of tissue polarity (GO:0007164)2.66194882
129establishment of planar polarity (GO:0001736)2.66194882
130membrane repolarization during action potential (GO:0086011)2.66018430
131axis elongation (GO:0003401)2.65219301
132positive regulation of cartilage development (GO:0061036)2.65167492
133morphogenesis of an epithelial fold (GO:0060571)2.63966384
134establishment of mitotic spindle orientation (GO:0000132)2.63644098
135purine nucleobase biosynthetic process (GO:0009113)2.62645676
136ganglion development (GO:0061548)2.62432168
137trophectodermal cell differentiation (GO:0001829)2.60816952
138* embryonic limb morphogenesis (GO:0030326)2.60733498
139* embryonic appendage morphogenesis (GO:0035113)2.60733498
140metanephros development (GO:0001656)2.59519292
141ribosomal large subunit biogenesis (GO:0042273)2.59418040
142lateral sprouting from an epithelium (GO:0060601)2.59216812
143peptidyl-arginine omega-N-methylation (GO:0035247)2.58392992
144regulation of double-strand break repair (GO:2000779)2.58066523
145rRNA metabolic process (GO:0016072)2.57963541
146establishment of mitotic spindle localization (GO:0040001)2.57927683
147regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57690917
148lung vasculature development (GO:0060426)2.57628644
149mesenchyme morphogenesis (GO:0072132)2.57467632
150UTP biosynthetic process (GO:0006228)2.57287825
151midgut development (GO:0007494)2.57211751
152epidermis development (GO:0008544)2.57077165
153proline biosynthetic process (GO:0006561)2.57043196
154negative regulation of catenin import into nucleus (GO:0035414)2.56584444
155negative regulation of embryonic development (GO:0045992)2.56579429
156aorta morphogenesis (GO:0035909)2.56220315
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.56141190
158mesodermal cell differentiation (GO:0048333)2.55946586
159anterior/posterior axis specification, embryo (GO:0008595)2.55787639
160regulation of translational elongation (GO:0006448)2.55603064
161glandular epithelial cell differentiation (GO:0002067)2.55396313
162kidney mesenchyme development (GO:0072074)2.55374293
163endocardial cushion development (GO:0003197)2.54633861
164* limb morphogenesis (GO:0035108)2.54468182
165* appendage morphogenesis (GO:0035107)2.54468182
166cell proliferation in forebrain (GO:0021846)2.54316330
167metanephric mesenchyme development (GO:0072075)2.54126981
168tRNA modification (GO:0006400)2.53909411
169cornea development in camera-type eye (GO:0061303)2.53210989
170keratinocyte development (GO:0003334)2.52373344
171positive regulation of fatty acid oxidation (GO:0046321)2.52342547
172keratinocyte proliferation (GO:0043616)2.52038274
173rRNA transcription (GO:0009303)2.51881941
174epithelial cell maturation (GO:0002070)2.50816164
175deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.48927847

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.45754464
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.31642344
3E2F7_22180533_ChIP-Seq_HELA_Human3.77394022
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.29275916
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.08223589
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.82603116
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76012936
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.69208483
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.65661460
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58288637
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.58136484
12AR_21909140_ChIP-Seq_LNCAP_Human2.44061953
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.42208744
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34639112
15VDR_21846776_ChIP-Seq_THP-1_Human2.26617942
16LXR_22292898_ChIP-Seq_THP-1_Human2.23242390
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19772381
18ZNF263_19887448_ChIP-Seq_K562_Human2.19334098
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18149637
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13017240
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.11096008
22* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08157188
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03355592
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03096708
25XRN2_22483619_ChIP-Seq_HELA_Human2.02875834
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87637508
27* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.83705634
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83235519
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83235519
30KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83235519
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.82918136
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.82270122
33P68_20966046_ChIP-Seq_HELA_Human1.81129868
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73880223
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73857122
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73162122
37* TP53_20018659_ChIP-ChIP_R1E_Mouse1.63450607
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61526932
39TTF2_22483619_ChIP-Seq_HELA_Human1.61284866
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59192247
41CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59165360
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56615953
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52634119
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52137890
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48775211
46TP53_22127205_ChIP-Seq_IMR90_Human1.47009099
47SA1_27219007_Chip-Seq_ERYTHROID_Human1.46285661
48ATF3_27146783_Chip-Seq_COLON_Human1.41881346
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41842027
50RACK7_27058665_Chip-Seq_MCF-7_Human1.41720218
51CLOCK_20551151_ChIP-Seq_293T_Human1.41303318
52SOX2_18692474_ChIP-Seq_MEFs_Mouse1.39946073
53* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39892038
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.39693392
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39271481
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38891871
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.37921661
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35545877
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34890300
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.34764079
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34693886
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.34686401
63E2F1_20622854_ChIP-Seq_HELA_Human1.34498501
64GABP_19822575_ChIP-Seq_HepG2_Human1.34318945
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.34279871
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33584602
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33366216
68OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31535396
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31370953
70* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30916401
71* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30884933
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.30519392
73KDM5A_27292631_Chip-Seq_BREAST_Human1.30318898
74CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28155022
75BCL6_27268052_Chip-Seq_Bcells_Human1.28076134
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27917832
77* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.27564046
78CTCF_20526341_ChIP-Seq_ESCs_Human1.26153049
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25503215
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25213149
81EST1_17652178_ChIP-ChIP_JURKAT_Human1.24845935
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24739490
83E2F1_21310950_ChIP-Seq_MCF-7_Human1.24550796
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.24352389
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23725838
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23393198
87BCOR_27268052_Chip-Seq_Bcells_Human1.22934832
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21960610
89CTCF_27219007_Chip-Seq_Bcells_Human1.21737415
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21000531
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.20994511
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20882492
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20751751
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20274705
95ESR1_21235772_ChIP-Seq_MCF-7_Human1.20147063
96* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19731695
97PHF8_20622854_ChIP-Seq_HELA_Human1.18829013
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18760474
99CTCF_26484167_Chip-Seq_Bcells_Mouse1.18511191
100CHD1_26751641_Chip-Seq_LNCaP_Human1.18455838
101* SMC4_20622854_ChIP-Seq_HELA_Human1.18209615
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18089935
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17218686
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.15621189
105CTCF_21964334_Chip-Seq_Bcells_Human1.15586449
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.15420659
107SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15175358
108TP63_22573176_ChIP-Seq_HFKS_Human1.15078966
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14693062
110RARA_24833708_ChIP-Seq_LIVER_Mouse1.14125897
111E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13499729
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12581345
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12213043
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11884857
115POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11816560
116NANOG_21062744_ChIP-ChIP_HESCs_Human1.11443772
117PKCTHETA_26484144_Chip-Seq_BREAST_Human1.11415076
118KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11347344
119* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11142983
120MYC_18940864_ChIP-ChIP_HL60_Human1.10738562
121* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10443546
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09989783
123DCP1A_22483619_ChIP-Seq_HELA_Human1.09691611
124* EED_16625203_ChIP-ChIP_MESCs_Mouse1.09537109
125* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09493015
126MYC_22102868_ChIP-Seq_BL_Human1.09369608
127YY1_21170310_ChIP-Seq_MESCs_Mouse1.08814422
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08137752
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07219753
130FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06644426
131CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06481986
132ESR2_21235772_ChIP-Seq_MCF-7_Human1.06342273
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06020348
134WT1_19549856_ChIP-ChIP_CCG9911_Human1.05653026
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04544017
136RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04005514
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03842651
138CREB1_26743006_Chip-Seq_LNCaP_Human1.03715177
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03304303
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02510202
141KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02138427
142SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.01463395
143* CDX2_20551321_ChIP-Seq_CACO-2_Human1.00485633
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99361947
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99361947
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.99263416
147SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99259849
148ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99054089
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98098731
150RARB_24833708_ChIP-Seq_LIVER_Mouse0.97792642
151JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97573669
152CTCF_21964334_ChIP-Seq_BJAB-B_Human0.96034398
153CIITA_25753668_ChIP-Seq_RAJI_Human0.95923686
154SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95260968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.46270443
2MP0010234_abnormal_vibrissa_follicle4.22969233
3MP0009053_abnormal_anal_canal4.11880794
4MP0003123_paternal_imprinting3.14333978
5MP0002653_abnormal_ependyma_morphology3.13080528
6MP0000537_abnormal_urethra_morphology3.06136239
7MP0005501_abnormal_skin_physiology2.64345585
8MP0000579_abnormal_nail_morphology2.64017876
9MP0003385_abnormal_body_wall2.61701404
10MP0003315_abnormal_perineum_morphology2.52137829
11* MP0009250_abnormal_appendicular_skeleto2.46522014
12MP0004185_abnormal_adipocyte_glucose2.39663570
13MP0002160_abnormal_reproductive_system2.38711777
14MP0008789_abnormal_olfactory_epithelium2.34990022
15* MP0003937_abnormal_limbs/digits/tail_de2.30492083
16* MP0000049_abnormal_middle_ear2.30196985
17MP0005503_abnormal_tendon_morphology2.21071751
18MP0000516_abnormal_urinary_system2.20804103
19MP0005367_renal/urinary_system_phenotyp2.20804103
20MP0003693_abnormal_embryo_hatching2.20336815
21MP0003705_abnormal_hypodermis_morpholog2.14950971
22MP0000733_abnormal_muscle_development2.06546806
23MP0009379_abnormal_foot_pigmentation2.03158517
24MP0002249_abnormal_larynx_morphology2.02038599
25MP0008438_abnormal_cutaneous_collagen2.00287953
26MP0005275_abnormal_skin_tensile1.98059671
27MP0005083_abnormal_biliary_tract1.96800043
28MP0002877_abnormal_melanocyte_morpholog1.90430728
29MP0000566_synostosis1.90076183
30MP0003119_abnormal_digestive_system1.89769984
31MP0003941_abnormal_skin_development1.88356457
32MP0002932_abnormal_joint_morphology1.81518382
33MP0000428_abnormal_craniofacial_morphol1.76704051
34MP0005499_abnormal_olfactory_system1.75206830
35MP0005394_taste/olfaction_phenotype1.75206830
36MP0003111_abnormal_nucleus_morphology1.74993077
37* MP0003755_abnormal_palate_morphology1.74920615
38MP0000681_abnormal_thyroid_gland1.73113975
39MP0000534_abnormal_ureter_morphology1.72836032
40MP0006292_abnormal_olfactory_placode1.71791240
41MP0003942_abnormal_urinary_system1.69577074
42MP0001661_extended_life_span1.69015286
43MP0000013_abnormal_adipose_tissue1.63949640
44MP0000467_abnormal_esophagus_morphology1.62155347
45MP0002111_abnormal_tail_morphology1.61884826
46MP0002233_abnormal_nose_morphology1.61103070
47* MP0003935_abnormal_craniofacial_develop1.60962746
48MP0001216_abnormal_epidermal_layer1.60675844
49MP0003122_maternal_imprinting1.60393543
50MP0004957_abnormal_blastocyst_morpholog1.58174142
51MP0001849_ear_inflammation1.55740901
52MP0003938_abnormal_ear_development1.55316137
53MP0005187_abnormal_penis_morphology1.53486697
54* MP0000762_abnormal_tongue_morphology1.52294845
55MP0010771_integument_phenotype1.51948932
56MP0009780_abnormal_chondrocyte_physiolo1.50403751
57MP0005508_abnormal_skeleton_morphology1.48412506
58MP0000462_abnormal_digestive_system1.47702431
59MP0005389_reproductive_system_phenotype1.47549628
60MP0004134_abnormal_chest_morphology1.46514358
61MP0003453_abnormal_keratinocyte_physiol1.46272847
62MP0009672_abnormal_birth_weight1.45247318
63MP0003115_abnormal_respiratory_system1.43326001
64MP0000432_abnormal_head_morphology1.43308155
65MP0004043_abnormal_pH_regulation1.42638786
66* MP0002116_abnormal_craniofacial_bone1.42115350
67MP0010678_abnormal_skin_adnexa1.39215166
68MP0002282_abnormal_trachea_morphology1.37638413
69MP0005623_abnormal_meninges_morphology1.35702488
70MP0008007_abnormal_cellular_replicative1.34044471
71MP0000383_abnormal_hair_follicle1.33552523
72MP0001986_abnormal_taste_sensitivity1.32624626
73MP0002163_abnormal_gland_morphology1.32569925
74MP0003283_abnormal_digestive_organ1.30864708
75MP0010352_gastrointestinal_tract_polyps1.30288490
76MP0003567_abnormal_fetal_cardiomyocyte1.28301586
77MP0002114_abnormal_axial_skeleton1.27740727
78MP0002177_abnormal_outer_ear1.27720436
79MP0005670_abnormal_white_adipose1.27503207
80MP0002092_abnormal_eye_morphology1.27459902
81MP0004272_abnormal_basement_membrane1.26977700
82MP0004233_abnormal_muscle_weight1.23942700
83MP0001293_anophthalmia1.23931298
84MP0008932_abnormal_embryonic_tissue1.23853016
85MP0006054_spinal_hemorrhage1.23734925
86* MP0002085_abnormal_embryonic_tissue1.23243014
87MP0001873_stomach_inflammation1.23228132
88MP0000470_abnormal_stomach_morphology1.23146906
89MP0005646_abnormal_pituitary_gland1.22646273
90MP0000350_abnormal_cell_proliferation1.22123744
91MP0005257_abnormal_intraocular_pressure1.20717211
92MP0000003_abnormal_adipose_tissue1.19080136
93MP0003786_premature_aging1.18384644
94MP0003077_abnormal_cell_cycle1.16857271
95MP0009703_decreased_birth_body1.16430215
96* MP0002109_abnormal_limb_morphology1.16244193
97MP0004197_abnormal_fetal_growth/weight/1.15057420
98MP0001346_abnormal_lacrimal_gland1.13469725
99MP0003121_genomic_imprinting1.13387362
100MP0004782_abnormal_surfactant_physiolog1.11525628
101MP0000377_abnormal_hair_follicle1.11342279
102MP0000163_abnormal_cartilage_morphology1.10975509
103MP0002234_abnormal_pharynx_morphology1.09269338
104MP0003718_maternal_effect1.08878779
105MP0000678_abnormal_parathyroid_gland1.07112136
106MP0002084_abnormal_developmental_patter1.06634355
107MP0005380_embryogenesis_phenotype1.06131385
108MP0001672_abnormal_embryogenesis/_devel1.06131385
109MP0009384_cardiac_valve_regurgitation1.06122648
110MP0001348_abnormal_lacrimal_gland1.04934298
111MP0001697_abnormal_embryo_size1.02225557
112MP0009333_abnormal_splenocyte_physiolog1.01720712
113* MP0002115_abnormal_skeleton_extremities1.01354610
114MP0001730_embryonic_growth_arrest0.99996759
115MP0000427_abnormal_hair_cycle0.98709500
116MP0005360_urolithiasis0.98503223
117MP0001286_abnormal_eye_development0.97467157
118MP0002098_abnormal_vibrissa_morphology0.95588240
119MP0004858_abnormal_nervous_system0.94986897
120MP0000627_abnormal_mammary_gland0.94950933
121MP0002089_abnormal_postnatal_growth/wei0.92793943
122MP0002796_impaired_skin_barrier0.92704928
123* MP0002113_abnormal_skeleton_development0.92230289
124MP0004264_abnormal_extraembryonic_tissu0.90567727
125MP0009931_abnormal_skin_appearance0.89053128
126MP0002938_white_spotting0.88325474
127MP0002697_abnormal_eye_size0.87049869
128MP0002088_abnormal_embryonic_growth/wei0.85598437
129MP0001919_abnormal_reproductive_system0.85083764
130MP0003984_embryonic_growth_retardation0.84877442
131MP0001243_abnormal_dermal_layer0.84352111
132MP0001299_abnormal_eye_distance/0.83800595
133MP0003878_abnormal_ear_physiology0.83222254
134MP0005377_hearing/vestibular/ear_phenot0.83222254
135MP0005076_abnormal_cell_differentiation0.82960486
136MP0001188_hyperpigmentation0.82381954
137MP0001340_abnormal_eyelid_morphology0.82245048
138MP0004885_abnormal_endolymph0.81909678
139MP0002086_abnormal_extraembryonic_tissu0.80732097
140* MP0000613_abnormal_salivary_gland0.78873601
141MP0003936_abnormal_reproductive_system0.78597739
142MP0010094_abnormal_chromosome_stability0.77576642
143MP0005023_abnormal_wound_healing0.77514050
144MP0002751_abnormal_autonomic_nervous0.77417492
145MP0001542_abnormal_bone_strength0.76796830
146MP0001270_distended_abdomen0.73668162
147MP0000750_abnormal_muscle_regeneration0.73400157
148MP0002060_abnormal_skin_morphology0.73143568
149MP0010368_abnormal_lymphatic_system0.73028898
150MP0003566_abnormal_cell_adhesion0.69825668
151MP0001765_abnormal_ion_homeostasis0.67646221
152MP0000367_abnormal_coat/_hair0.67612195
153MP0001664_abnormal_digestion0.67373006

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)4.51482157
2Shallow orbits (HP:0000586)4.27431661
3Premature rupture of membranes (HP:0001788)4.19073417
4Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56763297
5Short 4th metacarpal (HP:0010044)3.56763297
6Abnormality of the 4th metacarpal (HP:0010012)3.37874616
7Pendular nystagmus (HP:0012043)3.32198123
8Squamous cell carcinoma (HP:0002860)3.26969916
9Amelogenesis imperfecta (HP:0000705)3.15637228
10Abnormality of nail color (HP:0100643)3.13102521
11Short middle phalanx of the 5th finger (HP:0004220)3.12920968
12Abnormality of the phalanges of the hallux (HP:0010057)3.03181751
13Alopecia of scalp (HP:0002293)3.01444659
14Protrusio acetabuli (HP:0003179)2.99885656
15Oligodontia (HP:0000677)2.94722344
16Sparse eyelashes (HP:0000653)2.91828532
17Mesomelia (HP:0003027)2.90197976
18Abnormality of the 2nd finger (HP:0004100)2.89080138
19Short 1st metacarpal (HP:0010034)2.85736429
20Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.85736429
21Concave nail (HP:0001598)2.84701954
22Abnormality of the anterior horn cell (HP:0006802)2.78594534
23Degeneration of anterior horn cells (HP:0002398)2.78594534
24Abnormality of the distal phalanges of the toes (HP:0010182)2.78371303
25Morphological abnormality of the middle ear (HP:0008609)2.77145275
26Renal duplication (HP:0000075)2.76102047
27Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.75861974
28Atrophic scars (HP:0001075)2.75233932
29Trismus (HP:0000211)2.74275937
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.73934757
31Abnormality of the renal collecting system (HP:0004742)2.71863129
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68367263
33Abnormality of the 1st metacarpal (HP:0010009)2.67798884
34Abnormality of cells of the erythroid lineage (HP:0012130)2.66158701
35Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.66021954
36Broad metatarsal (HP:0001783)2.63951595
37Abnormal number of erythroid precursors (HP:0012131)2.60519583
38Broad toe (HP:0001837)2.57007741
39Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.55951957
40Ulnar bowing (HP:0003031)2.55896823
41Fragile nails (HP:0001808)2.53491506
42Hypotrichosis (HP:0001006)2.53017925
43Deviation of the hallux (HP:0010051)2.52114758
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.49440057
45Absent thumb (HP:0009777)2.48968462
46Hypoplasia of the uterus (HP:0000013)2.48539205
47Selective tooth agenesis (HP:0001592)2.47594876
48Rib fusion (HP:0000902)2.45393370
49Coronal craniosynostosis (HP:0004440)2.44875550
50Abnormality of the fetal cardiovascular system (HP:0010948)2.42714448
51Abnormal umbilical cord blood vessels (HP:0011403)2.42714448
52Single umbilical artery (HP:0001195)2.42714448
53Septate vagina (HP:0001153)2.42228684
54Abnormality of the phalanges of the 5th finger (HP:0004213)2.41993052
55Down-sloping shoulders (HP:0200021)2.39971150
56Erythroderma (HP:0001019)2.38020787
57Congenital ichthyosiform erythroderma (HP:0007431)2.37694019
58Thick nail (HP:0001805)2.36805066
59Nasolacrimal duct obstruction (HP:0000579)2.36414488
60Broad thumb (HP:0011304)2.35155647
61Short 5th finger (HP:0009237)2.33564273
62Hallux valgus (HP:0001822)2.33210769
63* Carpal synostosis (HP:0009702)2.32345478
64Short femoral neck (HP:0100864)2.31930709
65Broad hallux (HP:0010055)2.28763558
66Abnormality of the aortic arch (HP:0012303)2.28379928
67Short hallux (HP:0010109)2.28354043
68Broad distal phalanx of finger (HP:0009836)2.26471423
69Deformed tarsal bones (HP:0008119)2.25463025
70Pili torti (HP:0003777)2.25419570
71Carpal bone hypoplasia (HP:0001498)2.23735621
72Pseudobulbar signs (HP:0002200)2.22465822
73Palmoplantar hyperkeratosis (HP:0000972)2.21315383
74Hyperthyroidism (HP:0000836)2.20979142
75Fused cervical vertebrae (HP:0002949)2.20612521
76Short phalanx of the thumb (HP:0009660)2.19269527
77Broad phalanges of the hand (HP:0009768)2.18527289
78Abnormality of the middle phalanges of the toes (HP:0010183)2.18227916
79Abnormal hair laboratory examination (HP:0003328)2.16332336
80Reticulocytopenia (HP:0001896)2.15524196
81Nail dystrophy (HP:0008404)2.15178516
82Follicular hyperkeratosis (HP:0007502)2.14966989
83Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.14916415
84Abnormality of the umbilical cord (HP:0010881)2.13474721
85Microretrognathia (HP:0000308)2.12284674
86Broad long bones (HP:0005622)2.11751098
87Broad finger (HP:0001500)2.11634851
88Plantar hyperkeratosis (HP:0007556)2.11406160
89Fibular aplasia (HP:0002990)2.11259510
90Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.10775779
91Fragile skin (HP:0001030)2.10625353
92Nasal polyposis (HP:0100582)2.10185753
93Microglossia (HP:0000171)2.10068159
94Woolly hair (HP:0002224)2.09379793
95Aplasia/hypoplasia of the humerus (HP:0006507)2.07347531
96Duplicated collecting system (HP:0000081)2.07293608
97Milia (HP:0001056)2.06991131
98Aplasia/Hypoplasia of the hallux (HP:0008362)2.06923079
99Syringomyelia (HP:0003396)2.06163293
100Spinal cord lesions (HP:0100561)2.06163293
101Stridor (HP:0010307)2.06074568
102Abnormal number of incisors (HP:0011064)2.05531988
103Sparse lateral eyebrow (HP:0005338)2.05474583
104Broad phalanx (HP:0006009)2.01931823
105Unilateral renal agenesis (HP:0000122)2.01581098
106Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00827617
107Ridged nail (HP:0001807)2.00208222
108Cupped ribs (HP:0000887)1.99743628
109* Synostosis involving bones of the hand (HP:0004278)1.98609905
110Ureteral duplication (HP:0000073)1.97127995
111Acanthosis nigricans (HP:0000956)1.96959834
112Short middle phalanx of finger (HP:0005819)1.96607547
113Abnormality of the parietal bone (HP:0002696)1.95616470
114Aortic dissection (HP:0002647)1.94934458
115Atresia of the external auditory canal (HP:0000413)1.94608683
116Reduced subcutaneous adipose tissue (HP:0003758)1.93560405
117Sparse scalp hair (HP:0002209)1.93247559
118Oral leukoplakia (HP:0002745)1.93118892
119Palmar hyperkeratosis (HP:0010765)1.93073022
120Aplasia/Hypoplasia of the clavicles (HP:0006710)1.92876871
121Bowed forearm bones (HP:0003956)1.92349086
122Bowing of the arm (HP:0006488)1.92349086
123Soft skin (HP:0000977)1.92345014
124Skin pits (HP:0100276)1.92240698
125Patellar dislocation (HP:0002999)1.91797103
126Calcaneovalgus deformity (HP:0001848)1.91543547
127Breast hypoplasia (HP:0003187)1.91513928
128Aplasia/hypoplasia of the uterus (HP:0008684)1.91267960
129Abnormality of the distal phalanx of the thumb (HP:0009617)1.90536769
130Symphalangism affecting the phalanges of the hand (HP:0009773)1.90449529
131Hydroureter (HP:0000072)1.88623900
132Achilles tendon contracture (HP:0001771)1.88609062
133Abnormality of DNA repair (HP:0003254)1.87508952
134Partial duplication of the phalanx of hand (HP:0009999)1.87342341
135Decreased subcutaneous fat (HP:0001002)1.86859113
136Ankle contracture (HP:0006466)1.85982035
137* Aplasia/Hypoplasia of the patella (HP:0006498)1.84920260
138Testicular atrophy (HP:0000029)1.84822873
139Dilatation of the ascending aorta (HP:0005111)1.84797781
140Radial bowing (HP:0002986)1.84793677
141Corneal erosion (HP:0200020)1.83100044
142Vertebral fusion (HP:0002948)1.82970433
143Abnormality of the proximal phalanges of the hand (HP:0009834)1.82870513
144Short clavicles (HP:0000894)1.82466473
145Renal agenesis (HP:0000104)1.81213914
146* Synostosis of carpal bones (HP:0005048)1.81194020
147Cutaneous melanoma (HP:0012056)1.81166997
148Abnormality of the calcaneus (HP:0008364)1.80471632
149Increased corneal curvature (HP:0100692)1.80177900
150Keratoconus (HP:0000563)1.80177900
151Short thumb (HP:0009778)1.80052105
152Severe visual impairment (HP:0001141)1.78848888
153Hypoplasia of the radius (HP:0002984)1.78202161
154Absent phalangeal crease (HP:0006109)1.75507641
155Abnormality of the nasal mucosa (HP:0000433)1.75349991
156Genu recurvatum (HP:0002816)1.75163805
157Preaxial foot polydactyly (HP:0001841)1.74898345
158Mitral valve prolapse (HP:0001634)1.74171872
159Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.72089438
160Bladder diverticulum (HP:0000015)1.71731585
161Hypoplastic toenails (HP:0001800)1.71623070
162Pelvic girdle muscle weakness (HP:0003749)1.71410133
163Abnormality of subcutaneous fat tissue (HP:0001001)1.71184646
164Patellar aplasia (HP:0006443)1.71087538
165Pterygium (HP:0001059)1.70928064
166Choanal stenosis (HP:0000452)1.70486205
167Abnormality of the salivary glands (HP:0010286)1.69460569
168* Elbow flexion contracture (HP:0002987)1.69395966
169Abnormality of the nasal septum (HP:0000419)1.69060084
170Cheilitis (HP:0100825)1.66524691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.15008895
2BUB14.02398278
3NME23.88247441
4EPHB23.28402271
5MKNK13.25886067
6MKNK23.20179562
7LATS13.09220508
8MAPKAPK33.05213409
9SMG13.02883894
10SRPK13.00864062
11EPHA22.82895795
12IRAK32.75665903
13TTN2.71476891
14DDR22.63819066
15SIK12.48945961
16NEK22.42026533
17TRIB32.29427436
18ERN12.23514903
19LATS22.20796803
20MAP3K102.07695597
21ERBB32.05855334
22VRK21.99379776
23TTK1.97908892
24GRK11.86782679
25PIM21.79479626
26PRKD21.76986330
27TSSK61.75901830
28WEE11.70227209
29PAK41.69199028
30FLT31.67055201
31CDK81.66709827
32PLK41.57456036
33CDK191.51763595
34GRK61.43444751
35STK31.43436139
36BCKDK1.40308954
37MAP3K81.36574374
38STK38L1.33829657
39CDK61.33400287
40PDGFRA1.31638456
41RPS6KA41.28029079
42SCYL21.25500074
43AURKA1.25483509
44PLK31.25361870
45PLK11.18126368
46MAP2K21.16694114
47PAK21.14748527
48NUAK11.14641603
49RIPK11.13518163
50DYRK31.12110747
51MYLK1.10356188
52ADRBK21.10152656
53CLK11.08454822
54MUSK1.07398737
55CHEK21.06435386
56ABL21.04451661
57NME11.02939568
58RPS6KB20.99491884
59BRAF0.98689779
60PBK0.97937822
61NEK10.97312575
62PKN20.97267377
63CDC70.92761076
64MAP3K30.89144763
65MAP3K60.88923145
66AURKB0.88685875
67LRRK20.88425515
68WNK40.88193604
69PRKD30.87406376
70ZAK0.86889161
71LMTK20.86764732
72BRSK20.85834457
73PRKCI0.85004277
74ARAF0.84490316
75AKT30.83391050
76EPHA30.81938620
77PIK3CG0.80911444
78PAK10.79333556
79CDK40.78900815
80MAP2K30.78700384
81ALK0.77096842
82MAPK110.76882860
83PTK20.74935214
84CDK70.70566481
85RPS6KA20.69958406
86ILK0.69560716
87IKBKB0.68106481
88PTK60.66720495
89FGFR10.66113398
90TESK20.65021765
91FER0.64887631
92HIPK20.64747356
93CDK90.64649775
94EIF2AK20.64209978
95GRK50.63882048
96MTOR0.63397979
97GRK70.62557442
98CSNK1E0.62186024
99TAOK10.62019232
100DAPK30.61735552
101JAK30.60549181
102STK390.60195136
103TESK10.58944089
104RPS6KC10.58657450
105RPS6KL10.58657450
106ATR0.58457520
107TAOK20.58152278
108RPS6KA60.56102363
109CDK20.55595774
110MAP2K60.55340474
111ERBB20.54903311
112EEF2K0.54824066
113CHEK10.53650832
114MET0.52518876
115ADRBK10.52009375
116IRAK20.51833561
117PNCK0.51413290
118TAF10.51075650
119RPS6KA50.51022976
120MAP3K90.47958013
121STK160.46169507
122PASK0.43884803
123LIMK10.43743302
124STK40.43716203
125MAP3K110.43381291
126CDK120.43098826
127NEK90.43072117
128MAPKAPK20.41471255
129PDK20.41255563
130STK100.40678583
131ITK0.40524691
132BRSK10.40129654
133CSNK2A10.38795282
134ICK0.37049745
135CSNK1A1L0.36313971
136PDPK10.36251755
137BLK0.36195498
138AKT20.35210462
139TGFBR10.33893671
140CSNK1G10.33837978
141MAP2K10.32265882
142CDK10.31827253
143PRKG20.31618398
144CSNK2A20.31535524
145TRPM70.28344731
146CSNK1G30.28235244
147CAMK2G0.27327931
148CSNK1A10.26527911
149MST1R0.25088385
150EIF2AK10.23887694
151KDR0.23784449
152MAPK90.22949093
153BMX0.20812830

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.34397306
2Spliceosome_Homo sapiens_hsa030403.12060538
3Ribosome_Homo sapiens_hsa030103.04734995
4Hippo signaling pathway_Homo sapiens_hsa043902.84678715
5RNA transport_Homo sapiens_hsa030132.64142038
6Hedgehog signaling pathway_Homo sapiens_hsa043402.57185608
7Cell cycle_Homo sapiens_hsa041102.51914532
8DNA replication_Homo sapiens_hsa030302.33023346
9Proteasome_Homo sapiens_hsa030502.23673555
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23473376
11Sulfur relay system_Homo sapiens_hsa041222.05727764
12Base excision repair_Homo sapiens_hsa034102.01962654
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96907498
14One carbon pool by folate_Homo sapiens_hsa006701.96325807
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.95473334
16mRNA surveillance pathway_Homo sapiens_hsa030151.94903946
17RNA polymerase_Homo sapiens_hsa030201.83897774
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.82730138
19Folate biosynthesis_Homo sapiens_hsa007901.80299737
20Bladder cancer_Homo sapiens_hsa052191.73937405
21ECM-receptor interaction_Homo sapiens_hsa045121.70701142
22Homologous recombination_Homo sapiens_hsa034401.69400204
23Mismatch repair_Homo sapiens_hsa034301.66176869
24Oxidative phosphorylation_Homo sapiens_hsa001901.65609256
25Notch signaling pathway_Homo sapiens_hsa043301.65033883
26Oocyte meiosis_Homo sapiens_hsa041141.63577930
27Wnt signaling pathway_Homo sapiens_hsa043101.59946591
28Tight junction_Homo sapiens_hsa045301.55872103
29Proteoglycans in cancer_Homo sapiens_hsa052051.53632073
30p53 signaling pathway_Homo sapiens_hsa041151.50065310
31Adherens junction_Homo sapiens_hsa045201.49445214
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.46121045
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45864684
34Huntingtons disease_Homo sapiens_hsa050161.42747845
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42572268
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41485799
37TGF-beta signaling pathway_Homo sapiens_hsa043501.38365901
38MicroRNAs in cancer_Homo sapiens_hsa052061.34537804
39Nucleotide excision repair_Homo sapiens_hsa034201.32601287
40Melanogenesis_Homo sapiens_hsa049161.30610966
41Basal transcription factors_Homo sapiens_hsa030221.29215359
42Parkinsons disease_Homo sapiens_hsa050121.28177185
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.26205037
44Alzheimers disease_Homo sapiens_hsa050101.19382065
45Thyroid cancer_Homo sapiens_hsa052161.18763834
46HTLV-I infection_Homo sapiens_hsa051661.18404551
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17701724
48N-Glycan biosynthesis_Homo sapiens_hsa005101.15882440
49Glutathione metabolism_Homo sapiens_hsa004801.13701469
50Pyrimidine metabolism_Homo sapiens_hsa002401.13352214
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13116737
52Focal adhesion_Homo sapiens_hsa045101.04617739
53Protein digestion and absorption_Homo sapiens_hsa049740.99397084
54Fat digestion and absorption_Homo sapiens_hsa049750.96652807
55Small cell lung cancer_Homo sapiens_hsa052220.94428605
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94064602
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93077614
58Galactose metabolism_Homo sapiens_hsa000520.92770887
59Pentose phosphate pathway_Homo sapiens_hsa000300.89417515
60Chronic myeloid leukemia_Homo sapiens_hsa052200.88486041
61RNA degradation_Homo sapiens_hsa030180.82546128
62Prostate cancer_Homo sapiens_hsa052150.81320577
63Pathways in cancer_Homo sapiens_hsa052000.80727932
64Prion diseases_Homo sapiens_hsa050200.80696091
65Phototransduction_Homo sapiens_hsa047440.75946157
66Fanconi anemia pathway_Homo sapiens_hsa034600.74897786
67Systemic lupus erythematosus_Homo sapiens_hsa053220.73995112
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73326146
69Axon guidance_Homo sapiens_hsa043600.73193725
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72783470
71Cardiac muscle contraction_Homo sapiens_hsa042600.72377230
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72291763
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.69737453
74Biosynthesis of amino acids_Homo sapiens_hsa012300.68758400
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.66999572
76Arginine and proline metabolism_Homo sapiens_hsa003300.66625075
77Vitamin B6 metabolism_Homo sapiens_hsa007500.66351630
78Viral carcinogenesis_Homo sapiens_hsa052030.66218238
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64267531
80Sulfur metabolism_Homo sapiens_hsa009200.64149559
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63844136
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63781662
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63742386
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.62643037
85Epstein-Barr virus infection_Homo sapiens_hsa051690.61625592
86Selenocompound metabolism_Homo sapiens_hsa004500.60958693
87Phenylalanine metabolism_Homo sapiens_hsa003600.60726182
88Melanoma_Homo sapiens_hsa052180.59989212
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58309817
90Glioma_Homo sapiens_hsa052140.57837169
91Fructose and mannose metabolism_Homo sapiens_hsa000510.56298020
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55589772
93Endometrial cancer_Homo sapiens_hsa052130.55256484
94Mineral absorption_Homo sapiens_hsa049780.54259177
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53500232
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52629437
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52260941
98Metabolic pathways_Homo sapiens_hsa011000.51554886
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51286592
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51049029
101Purine metabolism_Homo sapiens_hsa002300.50756124
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50575045
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50384986
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50183212
105Chemical carcinogenesis_Homo sapiens_hsa052040.49792795
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49412084
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.49313591
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.49300425
109Retinol metabolism_Homo sapiens_hsa008300.47214807
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46157106
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.45907667
112Renin-angiotensin system_Homo sapiens_hsa046140.44611741
113Colorectal cancer_Homo sapiens_hsa052100.43969469
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42364450
115mTOR signaling pathway_Homo sapiens_hsa041500.40695250
116Tyrosine metabolism_Homo sapiens_hsa003500.40662866
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.39758778
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36714033
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36166309
120Renal cell carcinoma_Homo sapiens_hsa052110.35947102
121VEGF signaling pathway_Homo sapiens_hsa043700.35863365
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35836839
123FoxO signaling pathway_Homo sapiens_hsa040680.35729443
124Alcoholism_Homo sapiens_hsa050340.35558280
125Estrogen signaling pathway_Homo sapiens_hsa049150.34391903
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34088149
127Vitamin digestion and absorption_Homo sapiens_hsa049770.33908126
128Amoebiasis_Homo sapiens_hsa051460.33031515
129Hepatitis C_Homo sapiens_hsa051600.32424001
130Rap1 signaling pathway_Homo sapiens_hsa040150.31878109
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30325880
132Pancreatic cancer_Homo sapiens_hsa052120.29916307
133Pyruvate metabolism_Homo sapiens_hsa006200.26374958
134Non-small cell lung cancer_Homo sapiens_hsa052230.24749857
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24236529
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23614923

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