PITX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.35438932
2muscle filament sliding (GO:0030049)5.74203932
3actin-myosin filament sliding (GO:0033275)5.74203932
4peptidyl-arginine omega-N-methylation (GO:0035247)5.69270645
5muscle cell fate commitment (GO:0042693)5.64074826
6histone arginine methylation (GO:0034969)5.09719931
7actin-mediated cell contraction (GO:0070252)5.07994236
8peptidyl-arginine N-methylation (GO:0035246)5.00061857
9peptidyl-arginine methylation (GO:0018216)5.00061857
10negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.90628726
11otic vesicle formation (GO:0030916)4.76105178
12nucleobase catabolic process (GO:0046113)4.64670900
13response to pheromone (GO:0019236)4.59014621
14genitalia morphogenesis (GO:0035112)4.56076091
15erythrocyte maturation (GO:0043249)4.42012648
16glomerular basement membrane development (GO:0032836)4.37108154
17regulation of skeletal muscle contraction (GO:0014819)4.35473191
18negative regulation of astrocyte differentiation (GO:0048712)4.25711438
19urogenital system development (GO:0001655)4.20084193
20paraxial mesoderm development (GO:0048339)4.18271009
21negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.17735006
22embryonic foregut morphogenesis (GO:0048617)4.15386888
23cell migration involved in gastrulation (GO:0042074)3.99731497
24regulation of stem cell maintenance (GO:2000036)3.98758137
25negative regulation of microtubule polymerization (GO:0031115)3.94889719
26pre-miRNA processing (GO:0031054)3.90810042
27dopaminergic neuron differentiation (GO:0071542)3.89790610
28lateral sprouting from an epithelium (GO:0060601)3.87408989
29skeletal muscle contraction (GO:0003009)3.84895219
30limb bud formation (GO:0060174)3.83099388
31neuronal stem cell maintenance (GO:0097150)3.82460927
32outer ear morphogenesis (GO:0042473)3.79139037
33pattern specification involved in kidney development (GO:0061004)3.79004785
34regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.78319784
35chondrocyte proliferation (GO:0035988)3.78201805
36regulation of mesoderm development (GO:2000380)3.76432853
37dosage compensation (GO:0007549)3.68211975
38skeletal muscle adaptation (GO:0043501)3.66314911
39nodal signaling pathway (GO:0038092)3.57366772
40spinal cord association neuron differentiation (GO:0021527)3.56040443
41nucleosome disassembly (GO:0006337)3.55743101
42protein-DNA complex disassembly (GO:0032986)3.55743101
43negative regulation of cell fate specification (GO:0009996)3.53230106
44mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.52716728
45cranial nerve morphogenesis (GO:0021602)3.52158426
46actin filament-based movement (GO:0030048)3.48910199
47myofibril assembly (GO:0030239)3.41503998
48regulation of telomere maintenance via telomerase (GO:0032210)3.37330382
49thalamus development (GO:0021794)3.32615096
50striated muscle hypertrophy (GO:0014897)3.30454465
51regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.30079254
52organ induction (GO:0001759)3.27175071
53negative regulation of oligodendrocyte differentiation (GO:0048715)3.26270981
54renal system development (GO:0072001)3.25619674
55regulation of cardioblast differentiation (GO:0051890)3.23182763
56response to muscle activity (GO:0014850)3.21338569
57sarcoplasmic reticulum calcium ion transport (GO:0070296)3.18201273
58proteasome assembly (GO:0043248)3.17882907
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17196182
60signal transduction involved in regulation of gene expression (GO:0023019)3.17117252
61mesenchymal-epithelial cell signaling (GO:0060638)3.14037076
62cartilage morphogenesis (GO:0060536)3.13992167
63spliceosomal complex assembly (GO:0000245)3.13773872
64cardiac myofibril assembly (GO:0055003)3.09417187
65skeletal muscle fiber development (GO:0048741)3.08678819
66negative regulation of cell cycle arrest (GO:0071157)3.08121913
67DNA unwinding involved in DNA replication (GO:0006268)3.05013650
68negative regulation of RNA splicing (GO:0033119)3.04423181
69central nervous system myelination (GO:0022010)3.03853939
70axon ensheathment in central nervous system (GO:0032291)3.03853939
71sarcomere organization (GO:0045214)3.00843505
72radial glial cell differentiation (GO:0060019)3.00362695
73negative regulation of glial cell differentiation (GO:0045686)2.98818315
74midbrain development (GO:0030901)2.97408745
75RNA localization (GO:0006403)2.96255760
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.94511514
77myotube cell development (GO:0014904)2.94443895
78regulation of acyl-CoA biosynthetic process (GO:0050812)2.94275411
79tricarboxylic acid cycle (GO:0006099)2.94244801
80gastrulation with mouth forming second (GO:0001702)2.93529120
81regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.92794075
82peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.89796529
83response to inactivity (GO:0014854)2.88253570
84regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.87997072
85primitive streak formation (GO:0090009)2.87990711
86spliceosomal snRNP assembly (GO:0000387)2.87562367
87regulation of cofactor metabolic process (GO:0051193)2.86967192
88regulation of coenzyme metabolic process (GO:0051196)2.86967192
89kidney morphogenesis (GO:0060993)2.85363147
90establishment of integrated proviral latency (GO:0075713)2.83779407
91striated muscle adaptation (GO:0014888)2.82262143
92mesenchymal cell differentiation (GO:0048762)2.81020809
93muscle cell cellular homeostasis (GO:0046716)2.80990276
94striated muscle contraction (GO:0006941)2.79948738
95folic acid-containing compound biosynthetic process (GO:0009396)2.79148780
96central nervous system projection neuron axonogenesis (GO:0021952)2.77260832
97muscle hypertrophy (GO:0014896)2.76293938
98dendritic spine morphogenesis (GO:0060997)2.76235451
99outflow tract septum morphogenesis (GO:0003148)2.75419831
100negative regulation of mRNA processing (GO:0050686)2.74954777
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.74723199
102nephron tubule morphogenesis (GO:0072078)2.74412730
103nephron epithelium morphogenesis (GO:0072088)2.74412730
104negative regulation of axon extension involved in axon guidance (GO:0048843)2.74237318
105regulation of gastrulation (GO:0010470)2.74142630
106auditory receptor cell differentiation (GO:0042491)2.73145027
107peptidyl-arginine modification (GO:0018195)2.73082286
108regulation of gene silencing by RNA (GO:0060966)2.73035941
109regulation of posttranscriptional gene silencing (GO:0060147)2.73035941
110regulation of gene silencing by miRNA (GO:0060964)2.73035941
111DNA demethylation (GO:0080111)2.72844290
112positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.71931740
113regulation of relaxation of muscle (GO:1901077)2.71596689
114neuron fate determination (GO:0048664)2.70878458
115G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.69845041
116de novo protein folding (GO:0006458)2.69508742
117maturation of SSU-rRNA (GO:0030490)2.69307902
118* muscle tissue morphogenesis (GO:0060415)2.69110473
119gastrulation (GO:0007369)2.68807773
120cochlea morphogenesis (GO:0090103)2.68750229
121regulation of transforming growth factor beta2 production (GO:0032909)2.68565731
122anterior/posterior axis specification, embryo (GO:0008595)2.67825035
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.67154624
124branch elongation of an epithelium (GO:0060602)2.67071308
1254-hydroxyproline metabolic process (GO:0019471)2.64912760
126organ formation (GO:0048645)2.64721566
127mesenchymal cell proliferation (GO:0010463)2.64720928
128melanin biosynthetic process (GO:0042438)2.64364780
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.63650597
130de novo posttranslational protein folding (GO:0051084)2.63635353
131cellular response to vitamin (GO:0071295)2.63522154
132negative regulation of cell fate commitment (GO:0010454)2.63518694
133behavioral response to nicotine (GO:0035095)2.63252497
134* cardiac muscle tissue morphogenesis (GO:0055008)2.62075966
135ketone body metabolic process (GO:1902224)2.61992132
136response to UV-C (GO:0010225)2.61850200
137lung-associated mesenchyme development (GO:0060484)2.61154769
138forebrain neuron differentiation (GO:0021879)2.60789880
139plasma membrane repair (GO:0001778)2.60722803
140keratan sulfate catabolic process (GO:0042340)2.60721304
141epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60542647
142interkinetic nuclear migration (GO:0022027)2.60526873
143notochord development (GO:0030903)2.60399214
144negative regulation of embryonic development (GO:0045992)2.60310387
145segment specification (GO:0007379)2.59031646
146mRNA splice site selection (GO:0006376)2.58960973
147endoderm formation (GO:0001706)2.58787508
148regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57894848
149granulocyte differentiation (GO:0030851)2.57839599
150cornea development in camera-type eye (GO:0061303)2.57131913
151positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56784443
152positive regulation of gastrulation (GO:2000543)2.55686274
153* embryonic digestive tract morphogenesis (GO:0048557)2.54710384
154regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.54208903
155chaperone-mediated protein transport (GO:0072321)2.53783310
156* digestive tract morphogenesis (GO:0048546)2.52562064
157protein localization to cell surface (GO:0034394)2.52364785
158response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51210268
159axis elongation (GO:0003401)2.50769811
160negative regulation of axon guidance (GO:1902668)2.50625518
161spliceosomal tri-snRNP complex assembly (GO:0000244)2.50559743
162mitotic spindle assembly checkpoint (GO:0007094)2.50305325
163secondary metabolite biosynthetic process (GO:0044550)2.50203238
164negative regulation of gliogenesis (GO:0014014)2.49714326
165negative regulation of chromosome segregation (GO:0051985)2.49243066
166regulation of chromatin binding (GO:0035561)2.49044978
167negative regulation of mitotic sister chromatid segregation (GO:0033048)2.48632566
168negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.48632566
169negative regulation of sister chromatid segregation (GO:0033046)2.48632566
170negative regulation of mitotic sister chromatid separation (GO:2000816)2.48632566
171regulation of activin receptor signaling pathway (GO:0032925)2.48359071
172telencephalon development (GO:0021537)2.47884103
173negative regulation of DNA repair (GO:0045738)2.47444801
174epithelial cell-cell adhesion (GO:0090136)2.46677221
175mesenchymal to epithelial transition (GO:0060231)2.46203054
176somite rostral/caudal axis specification (GO:0032525)2.45927109
177histone deubiquitination (GO:0016578)2.45744144
178regulation of sulfur metabolic process (GO:0042762)2.45405048
179spindle assembly checkpoint (GO:0071173)2.45104879
180regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.45031447
181cardiac muscle hypertrophy (GO:0003300)2.44720084
182actomyosin structure organization (GO:0031032)2.44533332
183histamine secretion (GO:0001821)2.43621320
184cranial suture morphogenesis (GO:0060363)2.42771335
185anterior/posterior axis specification (GO:0009948)2.41272017
186* embryonic camera-type eye development (GO:0031076)2.40724972
187muscle contraction (GO:0006936)2.40651980
188dorsal/ventral axis specification (GO:0009950)2.39892722
189positive regulation of cardiac muscle cell proliferation (GO:0060045)2.39042196
190response to BMP (GO:0071772)2.39042160
191cellular response to BMP stimulus (GO:0071773)2.39042160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.96487200
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89803556
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.86469953
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.59224390
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.32997626
6EZH2_22144423_ChIP-Seq_EOC_Human3.20837643
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.20476395
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.00044477
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81915827
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.68455911
11XRN2_22483619_ChIP-Seq_HELA_Human2.66485235
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.64142127
13SRY_22984422_ChIP-ChIP_TESTIS_Rat2.58655952
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45780337
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.38304163
16* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.27182656
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17025486
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12960900
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08406003
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.06934557
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05630181
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03372991
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97164947
24SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.96940230
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.96052907
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93208354
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.91999325
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.89023234
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86889136
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.86669494
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.83189011
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82699963
33EP300_21415370_ChIP-Seq_HL-1_Mouse1.82054291
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.77621886
35* TP53_20018659_ChIP-ChIP_R1E_Mouse1.77325021
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75738793
37TTF2_22483619_ChIP-Seq_HELA_Human1.73017580
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70730871
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.70267584
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67205812
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65742320
42* SMAD3_21741376_ChIP-Seq_HESCs_Human1.64726090
43* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61962708
44* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.58581972
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58336993
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56740048
47* EOMES_21245162_ChIP-Seq_HESCs_Human1.55500629
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55443722
49MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54934232
50FUS_26573619_Chip-Seq_HEK293_Human1.54054736
51HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53522225
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50821466
53ETS1_20019798_ChIP-Seq_JURKAT_Human1.48827629
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.48745245
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47495361
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46964433
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45309961
58SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45242688
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45020495
60* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44758785
61VDR_22108803_ChIP-Seq_LS180_Human1.43326457
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41702573
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39799399
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38052927
65ZNF274_21170338_ChIP-Seq_K562_Hela1.35896381
66TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.35772105
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34622672
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.33809195
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.33739417
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.33376949
71WT1_19549856_ChIP-ChIP_CCG9911_Human1.32811056
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31596433
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31494105
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30638015
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30328767
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30203236
77* SOX2_16153702_ChIP-ChIP_HESCs_Human1.30037868
78* ISL1_27105846_Chip-Seq_CPCs_Mouse1.29866731
79IGF1R_20145208_ChIP-Seq_DFB_Human1.28610840
80AR_21909140_ChIP-Seq_LNCAP_Human1.28274817
81TP53_18474530_ChIP-ChIP_U2OS_Human1.28007055
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27280383
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27280383
84KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27280383
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26615212
86MYC_22102868_ChIP-Seq_BL_Human1.26340844
87CLOCK_20551151_ChIP-Seq_293T_Human1.26271776
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26190674
89* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25197504
90* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25197504
91* EZH2_27304074_Chip-Seq_ESCs_Mouse1.25053846
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24280525
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.24096107
94* CBX2_27304074_Chip-Seq_ESCs_Mouse1.23495427
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.21767670
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21113903
97* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20522566
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20489879
99* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19210109
100* P300_19829295_ChIP-Seq_ESCs_Human1.17140913
101SALL1_21062744_ChIP-ChIP_HESCs_Human1.16867740
102* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16838483
103EWS_26573619_Chip-Seq_HEK293_Human1.16179531
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16154546
105JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15843243
106* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15804523
107POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15218543
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.14640367
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13748523
110* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13240360
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12687486
112ELK1_19687146_ChIP-ChIP_HELA_Human1.12089805
113* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10397820
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09667334
115TRIM28_21343339_ChIP-Seq_HEK293_Human1.09666495
116RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09630077
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09215222
118FLI1_27457419_Chip-Seq_LIVER_Mouse1.08952860
119YY1_21170310_ChIP-Seq_MESCs_Mouse1.08463474
120SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08462993
121* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08262627
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07398623
123ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07283367
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07068231
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07036451
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06587283
127EST1_17652178_ChIP-ChIP_JURKAT_Human1.06331686
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.05704709
129* RING1B_27294783_Chip-Seq_NPCs_Mouse1.05309533
130HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05121263
131* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04149027
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03407351
133* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03371101
134* RNF2_27304074_Chip-Seq_NSC_Mouse1.03180778
135TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02792410
136GABP_17652178_ChIP-ChIP_JURKAT_Human1.02383063
137TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02340549
138PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02098897
139EZH2_27294783_Chip-Seq_NPCs_Mouse1.01649959
140TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00352226
141HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00269189
142GABP_19822575_ChIP-Seq_HepG2_Human0.99840473
143* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.99473344
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99237629
145POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98871281
146* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98688750
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98264317
148* NANOG_16153702_ChIP-ChIP_HESCs_Human0.98157699
149HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96650420
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96524068
151* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.96113320
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95529879
153SOX3_22085726_ChIP-Seq_NPCs_Mouse0.95132680
154NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94745070
155* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94633575
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93845703
157CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93533115
158PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91756675
159* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89283704
160* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89095111
161NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87303866
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87303866
163TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84507201
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84483045
165CRX_20693478_ChIP-Seq_RETINA_Mouse0.84437400
166SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84202540
167ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83053981
168* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82422371
169NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82310744
170* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81591873
171* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80479651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010030_abnormal_orbit_morphology3.70897030
2MP0003122_maternal_imprinting3.67642400
3MP0003878_abnormal_ear_physiology3.55474416
4MP0000749_muscle_degeneration3.45659169
5MP0000566_synostosis3.28314810
6MP0003315_abnormal_perineum_morphology3.20577593
7MP0003880_abnormal_central_pattern3.11052148
8MP0006276_abnormal_autonomic_nervous3.10595484
9MP0003283_abnormal_digestive_organ2.99109873
10MP0000537_abnormal_urethra_morphology2.92593260
11MP0000372_irregular_coat_pigmentation2.84809374
12MP0003121_genomic_imprinting2.67797052
13MP0008438_abnormal_cutaneous_collagen2.65366238
14MP0008995_early_reproductive_senescence2.56569373
15MP0002653_abnormal_ependyma_morphology2.41653907
16MP0003890_abnormal_embryonic-extraembry2.41358000
17MP0003123_paternal_imprinting2.35184768
18* MP0004133_heterotaxia2.34255003
19MP0005423_abnormal_somatic_nervous2.27650426
20MP0003119_abnormal_digestive_system2.22383766
21MP0002108_abnormal_muscle_morphology2.09645068
22MP0003567_abnormal_fetal_cardiomyocyte2.09014620
23MP0001730_embryonic_growth_arrest2.02916500
24MP0003646_muscle_fatigue1.96060167
25MP0002102_abnormal_ear_morphology1.89926658
26MP0005187_abnormal_penis_morphology1.87458124
27MP0000569_abnormal_digit_pigmentation1.85221736
28MP0000049_abnormal_middle_ear1.79412483
29MP0001661_extended_life_span1.78391040
30MP0004957_abnormal_blastocyst_morpholog1.73604864
31MP0002938_white_spotting1.71897476
32MP0008932_abnormal_embryonic_tissue1.71342454
33* MP0000759_abnormal_skeletal_muscle1.71170953
34MP0004087_abnormal_muscle_fiber1.68818677
35MP0005275_abnormal_skin_tensile1.67144318
36* MP0002084_abnormal_developmental_patter1.60790255
37MP0004036_abnormal_muscle_relaxation1.59731943
38MP0003693_abnormal_embryo_hatching1.58387721
39MP0002249_abnormal_larynx_morphology1.57705993
40MP0003937_abnormal_limbs/digits/tail_de1.57426305
41MP0000747_muscle_weakness1.56619941
42MP0003111_abnormal_nucleus_morphology1.55297378
43MP0002269_muscular_atrophy1.55173517
44* MP0002085_abnormal_embryonic_tissue1.51763965
45MP0000778_abnormal_nervous_system1.48893688
46MP0005257_abnormal_intraocular_pressure1.47375172
47MP0003077_abnormal_cell_cycle1.46143073
48MP0002932_abnormal_joint_morphology1.46005507
49MP0002234_abnormal_pharynx_morphology1.44921233
50MP0001529_abnormal_vocalization1.44904441
51MP0004197_abnormal_fetal_growth/weight/1.44461163
52MP0003941_abnormal_skin_development1.41719734
53MP0002751_abnormal_autonomic_nervous1.40208857
54MP0003950_abnormal_plasma_membrane1.38287581
55* MP0003861_abnormal_nervous_system1.37687212
56MP0005248_abnormal_Harderian_gland1.37300410
57MP0005380_embryogenesis_phenotype1.36677384
58MP0001672_abnormal_embryogenesis/_devel1.36677384
59* MP0003385_abnormal_body_wall1.36652001
60MP0000538_abnormal_urinary_bladder1.36172483
61* MP0001697_abnormal_embryo_size1.34536841
62MP0002233_abnormal_nose_morphology1.30352642
63MP0008961_abnormal_basal_metabolism1.29805520
64MP0000751_myopathy1.27695418
65MP0005330_cardiomyopathy1.27048658
66MP0000516_abnormal_urinary_system1.26614750
67MP0005367_renal/urinary_system_phenotyp1.26614750
68MP0002127_abnormal_cardiovascular_syste1.26547935
69MP0004233_abnormal_muscle_weight1.26072076
70MP0001849_ear_inflammation1.25950740
71MP0001346_abnormal_lacrimal_gland1.25882926
72MP0004084_abnormal_cardiac_muscle1.25777175
73MP0002088_abnormal_embryonic_growth/wei1.25099443
74MP0002282_abnormal_trachea_morphology1.24731253
75MP0003984_embryonic_growth_retardation1.23658234
76MP0002111_abnormal_tail_morphology1.23487294
77MP0005620_abnormal_muscle_contractility1.22685142
78MP0003115_abnormal_respiratory_system1.21677660
79MP0000750_abnormal_muscle_regeneration1.21376990
80MP0003786_premature_aging1.21334963
81MP0000350_abnormal_cell_proliferation1.19927785
82MP0003136_yellow_coat_color1.18662315
83MP0003942_abnormal_urinary_system1.17820383
84* MP0005197_abnormal_uvea_morphology1.16577903
85MP0009250_abnormal_appendicular_skeleto1.15114004
86MP0002089_abnormal_postnatal_growth/wei1.15096550
87MP0002638_abnormal_pupillary_reflex1.13655538
88MP0005171_absent_coat_pigmentation1.12461947
89MP0002086_abnormal_extraembryonic_tissu1.12075174
90MP0000462_abnormal_digestive_system1.12072857
91MP0004145_abnormal_muscle_electrophysio1.10883812
92MP0010094_abnormal_chromosome_stability1.10671408
93MP0006054_spinal_hemorrhage1.08119654
94MP0008007_abnormal_cellular_replicative1.07110787
95MP0009053_abnormal_anal_canal1.06425329
96* MP0005193_abnormal_anterior_eye1.01443671
97* MP0001299_abnormal_eye_distance/1.01428245
98MP0004885_abnormal_endolymph1.01398536
99* MP0003935_abnormal_craniofacial_develop0.98863728
100MP0002972_abnormal_cardiac_muscle0.96359800
101MP0010630_abnormal_cardiac_muscle0.95915486
102MP0005451_abnormal_body_composition0.95787022
103MP0002106_abnormal_muscle_physiology0.95591670
104* MP0002116_abnormal_craniofacial_bone0.94880921
105* MP0003755_abnormal_palate_morphology0.94089809
106MP0000534_abnormal_ureter_morphology0.93515256
107* MP0002697_abnormal_eye_size0.91451999
108* MP0000733_abnormal_muscle_development0.89913702
109* MP0002080_prenatal_lethality0.89354258
110MP0000428_abnormal_craniofacial_morphol0.88017599
111* MP0001286_abnormal_eye_development0.87841405
112* MP0003137_abnormal_impulse_conducting0.86495589
113MP0003938_abnormal_ear_development0.86311621
114MP0005503_abnormal_tendon_morphology0.86124453
115MP0002332_abnormal_exercise_endurance0.85807195
116MP0002132_abnormal_respiratory_system0.85579787
117* MP0000432_abnormal_head_morphology0.84767121
118MP0001293_anophthalmia0.84584988
119* MP0002114_abnormal_axial_skeleton0.83949035
120MP0004264_abnormal_extraembryonic_tissu0.83805843
121MP0002277_abnormal_respiratory_mucosa0.83455250
122MP0001324_abnormal_eye_pigmentation0.82947291
123MP0009384_cardiac_valve_regurgitation0.82446586
124MP0005623_abnormal_meninges_morphology0.81597768
125MP0004215_abnormal_myocardial_fiber0.79862658
126MP0002184_abnormal_innervation0.79615595
127* MP0002081_perinatal_lethality0.79544140
128MP0005645_abnormal_hypothalamus_physiol0.77944952
129MP0005508_abnormal_skeleton_morphology0.77649569
130MP0010386_abnormal_urinary_bladder0.76767386
131MP0003279_aneurysm0.75775960
132MP0002295_abnormal_pulmonary_circulatio0.75655588
133MP0004272_abnormal_basement_membrane0.74384473
134MP0005369_muscle_phenotype0.74372292
135MP0003705_abnormal_hypodermis_morpholog0.74229455
136MP0000026_abnormal_inner_ear0.73636513
137MP0008058_abnormal_DNA_repair0.73492900
138MP0000762_abnormal_tongue_morphology0.72636267
139MP0009840_abnormal_foam_cell0.72532444
140MP0002109_abnormal_limb_morphology0.72172235
141MP0003221_abnormal_cardiomyocyte_apopto0.71247563
142* MP0002152_abnormal_brain_morphology0.71191053
143MP0005084_abnormal_gallbladder_morpholo0.71018850
144* MP0002092_abnormal_eye_morphology0.70599691
145MP0001544_abnormal_cardiovascular_syste0.69886108
146MP0005385_cardiovascular_system_phenoty0.69886108
147MP0003186_abnormal_redox_activity0.69136672
148MP0000579_abnormal_nail_morphology0.68891656
149MP0005377_hearing/vestibular/ear_phenot0.66816727

Predicted human phenotypes

RankGene SetZ-score
1Popliteal pterygium (HP:0009756)4.77596226
2Exercise-induced muscle cramps (HP:0003710)4.34844644
3Exercise-induced myalgia (HP:0003738)4.20746639
4Distal arthrogryposis (HP:0005684)3.99157121
5Type 2 muscle fiber atrophy (HP:0003554)3.96276488
6Intestinal atresia (HP:0011100)3.80785449
7Failure to thrive in infancy (HP:0001531)3.70984005
8Muscle hypertrophy of the lower extremities (HP:0008968)3.68755116
9Partial duplication of the phalanx of hand (HP:0009999)3.64831572
10Partial duplication of thumb phalanx (HP:0009944)3.41404020
11Aplasia of the musculature (HP:0100854)3.37591888
12Supernumerary spleens (HP:0009799)3.36512255
13Abnormality of the labia minora (HP:0012880)3.36133782
14Muscle fiber atrophy (HP:0100295)3.35554788
15Round ear (HP:0100830)3.26288008
16Fatigable weakness (HP:0003473)3.17632882
17Abnormality of the neuromuscular junction (HP:0003398)3.17632882
18Trismus (HP:0000211)3.13744189
19Weak cry (HP:0001612)3.12427671
20Neonatal short-limb short stature (HP:0008921)3.10023290
21Esophageal atresia (HP:0002032)3.00760566
22Calcaneovalgus deformity (HP:0001848)2.95902097
23Abnormality of the calf musculature (HP:0001430)2.94272421
24Neoplasm of the adrenal cortex (HP:0100641)2.91662367
25Abnormality of the 2nd finger (HP:0004100)2.88311861
26Increased serum pyruvate (HP:0003542)2.85810028
27Abnormality of glycolysis (HP:0004366)2.85810028
28Neck muscle weakness (HP:0000467)2.82774515
29Nonprogressive disorder (HP:0003680)2.80718858
30Malignant hyperthermia (HP:0002047)2.78458645
31Wrist flexion contracture (HP:0001239)2.76486876
32Premature rupture of membranes (HP:0001788)2.74254002
33Absent phalangeal crease (HP:0006109)2.72776648
34Ulnar deviation of the wrist (HP:0003049)2.67448786
35Rimmed vacuoles (HP:0003805)2.66661458
36Short palpebral fissure (HP:0012745)2.66102760
37Gowers sign (HP:0003391)2.65657668
38High anterior hairline (HP:0009890)2.63910567
39Deformed tarsal bones (HP:0008119)2.63799213
40Concave nail (HP:0001598)2.61435933
41Polyphagia (HP:0002591)2.54478132
42Abdominal situs inversus (HP:0003363)2.53783840
43Abnormality of abdominal situs (HP:0011620)2.53783840
44Aplasia/Hypoplasia involving the musculature (HP:0001460)2.51659874
45Renal duplication (HP:0000075)2.49951333
46Neoplasm of the adrenal gland (HP:0100631)2.48088513
47EMG: myopathic abnormalities (HP:0003458)2.47089832
48Thin ribs (HP:0000883)2.46986755
49Asplenia (HP:0001746)2.46831569
50Ependymoma (HP:0002888)2.44643261
51Hyporeflexia of lower limbs (HP:0002600)2.42479185
52Absent radius (HP:0003974)2.41737099
53Aplasia/Hypoplasia of the patella (HP:0006498)2.41006775
54Abnormality of the phalanges of the 2nd finger (HP:0009541)2.40331317
55Muscle fiber splitting (HP:0003555)2.40228597
56Shoulder girdle muscle weakness (HP:0003547)2.37397064
57Annular pancreas (HP:0001734)2.34432731
58Fetal akinesia sequence (HP:0001989)2.33966329
59Absent forearm bone (HP:0003953)2.33493262
60Aplasia involving forearm bones (HP:0009822)2.33493262
61Reticulocytopenia (HP:0001896)2.33444176
62Patellar aplasia (HP:0006443)2.33185746
63Rhabdomyolysis (HP:0003201)2.29474428
64Pterygium (HP:0001059)2.27583002
65Aplasia of the phalanges of the hand (HP:0009802)2.25784872
66Aplasia involving bones of the extremities (HP:0009825)2.25784872
67Aplasia involving bones of the upper limbs (HP:0009823)2.25784872
68Abnormal finger flexion creases (HP:0006143)2.25760740
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.25022935
70Aplasia/Hypoplasia of the spleen (HP:0010451)2.24430864
71Hyperacusis (HP:0010780)2.24426819
72Hydroureter (HP:0000072)2.23740772
73Increased nuchal translucency (HP:0010880)2.21316815
74Degeneration of anterior horn cells (HP:0002398)2.21142226
75Abnormality of the anterior horn cell (HP:0006802)2.21142226
76Easy fatigability (HP:0003388)2.19659817
77Proximal placement of thumb (HP:0009623)2.18260813
78Muscle fiber inclusion bodies (HP:0100299)2.17202610
79Abnormality of placental membranes (HP:0011409)2.16088586
80Amniotic constriction ring (HP:0009775)2.16088586
81Abnormality of the left ventricular outflow tract (HP:0011103)2.15196359
82Subaortic stenosis (HP:0001682)2.15196359
83Ridged nail (HP:0001807)2.13560639
84Nemaline bodies (HP:0003798)2.12788442
85Hypoplastic heart (HP:0001961)2.12562098
86Depressed nasal tip (HP:0000437)2.12056950
87Long clavicles (HP:0000890)2.11231948
88Abnormal number of incisors (HP:0011064)2.11219748
89Abnormality of the umbilical cord (HP:0010881)2.10486240
90Bell-shaped thorax (HP:0001591)2.10137930
91Deviation of the thumb (HP:0009603)2.07750011
92Cortical dysplasia (HP:0002539)2.06630929
93Areflexia of lower limbs (HP:0002522)2.05684605
94Duplication of thumb phalanx (HP:0009942)2.03389942
95Abnormalities of placenta or umbilical cord (HP:0001194)2.02647434
96Abnormality of the astrocytes (HP:0100707)2.02057128
97Astrocytoma (HP:0009592)2.02057128
98Leiomyosarcoma (HP:0100243)2.00767010
99Uterine leiomyosarcoma (HP:0002891)2.00767010
100Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00280334
101Hypoplasia of the brainstem (HP:0002365)2.00280334
102Short 4th metacarpal (HP:0010044)1.99525390
103Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99525390
104Myotonia (HP:0002486)1.97921040
105Exostoses (HP:0100777)1.97887640
106Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.97161053
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.97103524
108Soft skin (HP:0000977)1.95979099
109Sleep apnea (HP:0010535)1.94779367
110Pelvic girdle muscle weakness (HP:0003749)1.93626630
111Abnormality of the upper arm (HP:0001454)1.92121174
112Myopathic facies (HP:0002058)1.91677333
113Aortic dissection (HP:0002647)1.91283610
114Myoglobinuria (HP:0002913)1.89256514
115Recurrent corneal erosions (HP:0000495)1.89197850
116Selective tooth agenesis (HP:0001592)1.88246185
117Abnormality of the ischium (HP:0003174)1.86645644
118Patellar dislocation (HP:0002999)1.86229671
119Adducted thumb (HP:0001181)1.86223989
120Alacrima (HP:0000522)1.85885939
121Preaxial foot polydactyly (HP:0001841)1.84982852
122Abnormal delivery (HP:0001787)1.84822641
123Symphalangism affecting the phalanges of the hand (HP:0009773)1.84336345
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83399433
125Abnormality of alanine metabolism (HP:0010916)1.83399433
126Hyperalaninemia (HP:0003348)1.83399433
127Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.82743438
12811 pairs of ribs (HP:0000878)1.82448023
129Decreased lacrimation (HP:0000633)1.81595607
130Elfin facies (HP:0004428)1.80903969
131Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.80548766
132Trigonocephaly (HP:0000243)1.78719820
133Respiratory insufficiency due to muscle weakness (HP:0002747)1.77925457
134Delayed gross motor development (HP:0002194)1.77336838
135Abnormality of the fetal cardiovascular system (HP:0010948)1.77137606
136Abnormal umbilical cord blood vessels (HP:0011403)1.77137606
137Single umbilical artery (HP:0001195)1.77137606
138Gastrointestinal atresia (HP:0002589)1.76999252
139Bifid tongue (HP:0010297)1.76872064
140Hypoalphalipoproteinemia (HP:0003233)1.76668818
141Acute necrotizing encephalopathy (HP:0006965)1.76642806
142Spontaneous abortion (HP:0005268)1.74920350
143Muscle stiffness (HP:0003552)1.74763750
144Bronchomalacia (HP:0002780)1.74496051
145Abnormal sex determination (HP:0012244)1.73904509
146Sex reversal (HP:0012245)1.73904509
147Calf muscle hypertrophy (HP:0008981)1.73109072
148Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72364433
149Coronal craniosynostosis (HP:0004440)1.72277136
150Nasal speech (HP:0001611)1.72082086
151Infantile muscular hypotonia (HP:0008947)1.71955891
152Glossoptosis (HP:0000162)1.71674732
153Patchy hypopigmentation of hair (HP:0011365)1.71282974
154Mixed hearing impairment (HP:0000410)1.70863722
155Abnormality of the calcaneus (HP:0008364)1.70362292
156Abnormality of the vocal cords (HP:0008777)1.69856474
157Malignant gastrointestinal tract tumors (HP:0006749)1.69408487
158Gastrointestinal carcinoma (HP:0002672)1.69408487
159Exotropia (HP:0000577)1.69257265
160Aplasia/hypoplasia of the humerus (HP:0006507)1.69065201
161Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.69039445
162Renovascular hypertension (HP:0100817)1.67512917
163Type 1 muscle fiber predominance (HP:0003803)1.67130725
164Abnormality of the nasolacrimal system (HP:0000614)1.65389978
165Overriding aorta (HP:0002623)1.64421987
166Limb-girdle muscle atrophy (HP:0003797)1.63658074
167Short phalanx of the thumb (HP:0009660)1.63646079
168Decreased muscle mass (HP:0003199)1.62822216
169Carpal synostosis (HP:0009702)1.62735231
170Acute encephalopathy (HP:0006846)1.62332602
171Abnormality of skeletal muscle fiber size (HP:0012084)1.62059032
172Abnormal mitochondria in muscle tissue (HP:0008316)1.61894291
173Abnormality of the 1st metacarpal (HP:0010009)1.61881324
174Neoplasm of the heart (HP:0100544)1.61625179
175Hypoplastic toenails (HP:0001800)1.61255454
176Abnormal pancreas size (HP:0012094)1.60406429
177Right ventricular cardiomyopathy (HP:0011663)1.59398291
178Abnormality of the aortic arch (HP:0012303)1.59286473
179Spina bifida occulta (HP:0003298)1.59194814
180Hyperkalemia (HP:0002153)1.58659883
181White forelock (HP:0002211)1.57872999
182Hip contracture (HP:0003273)1.57752830
183Mildly elevated creatine phosphokinase (HP:0008180)1.56895003
184Lipoatrophy (HP:0100578)1.55245087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK36.07378547
2MUSK5.24043068
3BCR4.33585064
4PDK24.11365871
5PLK43.47090376
6BUB13.37769522
7KSR13.31556152
8DYRK22.81912413
9EPHB22.68892977
10PHKG22.64968569
11PHKG12.64968569
12LIMK12.39623468
13NTRK22.22302965
14PBK2.10601077
15UHMK12.04816184
16DYRK31.93206374
17EIF2AK11.92880036
18MARK11.91902958
19FGFR21.87844427
20TYRO31.71707678
21STK161.70864192
22TESK21.70564313
23LATS11.66393154
24SRPK11.62636237
25MAP3K121.62428104
26MOS1.59077159
27TRIM281.56584244
28TESK11.50145370
29MINK11.49357177
30PDGFRA1.48193577
31TGFBR11.47574164
32CDK121.46906508
33MAP3K101.46502429
34BRD41.46397222
35PIK3CG1.46252975
36ICK1.40046968
37EIF2AK31.38969041
38ERBB31.34848330
39PINK11.33795043
40FGFR11.31563350
41BMPR1B1.30966694
42NEK11.27431494
43CDC71.24758005
44ERBB21.24535692
45OBSCN1.23889124
46VRK21.19908751
47MAP2K11.17082453
48CDK181.11590142
49CDK81.10962291
50STK38L1.08908192
51MKNK21.08296758
52NME11.07902759
53TGFBR21.07867508
54PAK41.05520350
55ACVR1B1.04869251
56SIK21.00007467
57DYRK1B0.99773043
58AURKA0.96180699
59WNK30.96092524
60FGFR40.92974791
61CDK70.90683831
62EEF2K0.89585955
63CSNK1G10.89225338
64ERBB40.88769394
65PLK20.86603013
66MTOR0.86390581
67TTK0.85930938
68CDK140.84490235
69TLK10.83716378
70MKNK10.83603136
71PNCK0.82824784
72EPHA20.82763789
73MAP3K110.82645371
74* AKT20.81359786
75MELK0.80344381
76TSSK60.79447231
77CDK150.78954553
78MYLK0.77652580
79AURKB0.77065317
80LATS20.76041127
81CDK11A0.74737136
82TTN0.73644323
83MET0.72455957
84STK390.71670562
85PAK30.71466080
86ATR0.71004749
87RPS6KB20.69820634
88PLK10.68942361
89NEK20.68702283
90PIM10.68384072
91CCNB10.67389441
92DDR20.67165962
93MAP2K40.66074215
94TNIK0.64921714
95FGFR30.62712334
96PAK10.60316453
97EPHA40.59396482
98CSNK1E0.58904968
99MAP3K90.58244308
100RIPK10.58157743
101PASK0.57418910
102MAPK90.57216266
103RPS6KB10.56414796
104ROCK10.55542313
105EIF2AK20.55477105
106MAPK130.55382217
107ROCK20.54829902
108MST1R0.53005839
109CHEK20.52551543
110MAP2K20.52065241
111PLK30.51301654
112CDK10.50235689
113CDK20.50054074
114CHEK10.49707169
115PIK3CA0.49103002
116KDR0.48918675
117STK30.47876092
118PAK20.47443289
119PRKCI0.46128504
120CSNK1G20.45690381
121CDK60.45196318
122ADRBK10.44489289
123ILK0.44003097
124CDK40.43826529
125ZAK0.43614279
126WEE10.41579549
127VRK10.41262829
128MAPK150.40886766
129NLK0.40435158
130GRK10.39802287
131CDK90.38932401
132CDK190.38458903
133NUAK10.37819200
134CAMK2B0.37696633
135BRSK20.37625679
136CSNK1G30.37439452
137PRKACB0.37089839
138DAPK30.36754555
139CSNK2A10.35774924
140MARK20.34257436
141PAK60.32559520
142AKT10.32191273
143CSNK1D0.31980686
144CDC42BPA0.31081447
145RPS6KA10.30937629
146CSNK2A20.30934815
147NEK90.28351563
148BRSK10.27596701
149TIE10.26065935
150MAP3K70.25952135
151MAPK70.23846528
152PRKAA20.21354735
153MAP3K40.20405705
154OXSR10.18615104

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.63734190
2Notch signaling pathway_Homo sapiens_hsa043303.03670530
3Basal cell carcinoma_Homo sapiens_hsa052172.81404776
4RNA transport_Homo sapiens_hsa030132.72606898
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.60035886
6Ribosome_Homo sapiens_hsa030102.41246352
7Cell cycle_Homo sapiens_hsa041102.27934245
8Hedgehog signaling pathway_Homo sapiens_hsa043402.27347010
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26553896
10Base excision repair_Homo sapiens_hsa034102.24368016
11Hippo signaling pathway_Homo sapiens_hsa043902.23501818
12One carbon pool by folate_Homo sapiens_hsa006702.07404806
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.05733911
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.05119219
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03914593
16Pyruvate metabolism_Homo sapiens_hsa006202.01754427
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98435311
18mRNA surveillance pathway_Homo sapiens_hsa030151.97712194
19Mismatch repair_Homo sapiens_hsa034301.94011095
20Nitrogen metabolism_Homo sapiens_hsa009101.89678154
21Axon guidance_Homo sapiens_hsa043601.89668849
22DNA replication_Homo sapiens_hsa030301.87986112
23Cardiac muscle contraction_Homo sapiens_hsa042601.87179926
24RNA polymerase_Homo sapiens_hsa030201.80164486
25Proteasome_Homo sapiens_hsa030501.74540006
26Bladder cancer_Homo sapiens_hsa052191.70183149
27Propanoate metabolism_Homo sapiens_hsa006401.63777050
28Sulfur relay system_Homo sapiens_hsa041221.63754092
29Protein export_Homo sapiens_hsa030601.61524016
30Pyrimidine metabolism_Homo sapiens_hsa002401.58189816
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55011739
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54978846
33Protein digestion and absorption_Homo sapiens_hsa049741.48471811
34ECM-receptor interaction_Homo sapiens_hsa045121.48377345
35Parkinsons disease_Homo sapiens_hsa050121.48178717
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47635117
37p53 signaling pathway_Homo sapiens_hsa041151.46030992
38Sulfur metabolism_Homo sapiens_hsa009201.44955266
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.44100290
40Oocyte meiosis_Homo sapiens_hsa041141.38208549
41MicroRNAs in cancer_Homo sapiens_hsa052061.36476603
42Tight junction_Homo sapiens_hsa045301.36442857
43Wnt signaling pathway_Homo sapiens_hsa043101.30095472
44* TGF-beta signaling pathway_Homo sapiens_hsa043501.27434016
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22665532
46Oxidative phosphorylation_Homo sapiens_hsa001901.22316571
47Huntingtons disease_Homo sapiens_hsa050161.21817353
48Selenocompound metabolism_Homo sapiens_hsa004501.21153513
49RNA degradation_Homo sapiens_hsa030181.19774768
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14424413
51Colorectal cancer_Homo sapiens_hsa052101.14067259
52Viral myocarditis_Homo sapiens_hsa054161.12221460
53Adherens junction_Homo sapiens_hsa045201.08045193
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05618272
55Nucleotide excision repair_Homo sapiens_hsa034201.05166309
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.03919521
57Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03908113
58Biosynthesis of amino acids_Homo sapiens_hsa012301.02961554
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02776756
60Circadian rhythm_Homo sapiens_hsa047101.00254367
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96929261
62Fat digestion and absorption_Homo sapiens_hsa049750.95028142
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94784217
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93500858
65Arginine biosynthesis_Homo sapiens_hsa002200.92073958
66Proteoglycans in cancer_Homo sapiens_hsa052050.88186590
67Fatty acid degradation_Homo sapiens_hsa000710.84351664
68Fatty acid elongation_Homo sapiens_hsa000620.82825255
69Carbon metabolism_Homo sapiens_hsa012000.81074950
70Pathways in cancer_Homo sapiens_hsa052000.80770813
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80012229
72Glucagon signaling pathway_Homo sapiens_hsa049220.77553749
73Homologous recombination_Homo sapiens_hsa034400.77514260
74Peroxisome_Homo sapiens_hsa041460.76746926
75Dilated cardiomyopathy_Homo sapiens_hsa054140.75056253
76Focal adhesion_Homo sapiens_hsa045100.74910415
77Lysine degradation_Homo sapiens_hsa003100.74890881
78Gap junction_Homo sapiens_hsa045400.73723719
79Melanogenesis_Homo sapiens_hsa049160.72099746
80Vitamin digestion and absorption_Homo sapiens_hsa049770.71905879
81Epstein-Barr virus infection_Homo sapiens_hsa051690.71158037
82Alzheimers disease_Homo sapiens_hsa050100.71126182
83Non-homologous end-joining_Homo sapiens_hsa034500.69579306
84HTLV-I infection_Homo sapiens_hsa051660.69156060
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.67952862
86Basal transcription factors_Homo sapiens_hsa030220.66082738
87Chronic myeloid leukemia_Homo sapiens_hsa052200.65385188
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65285329
89Fanconi anemia pathway_Homo sapiens_hsa034600.62364478
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61836673
91Shigellosis_Homo sapiens_hsa051310.60518564
92Metabolic pathways_Homo sapiens_hsa011000.60256586
93Systemic lupus erythematosus_Homo sapiens_hsa053220.59980593
94Prion diseases_Homo sapiens_hsa050200.59957415
95Butanoate metabolism_Homo sapiens_hsa006500.59386290
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57954316
97beta-Alanine metabolism_Homo sapiens_hsa004100.57491041
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56120533
99Small cell lung cancer_Homo sapiens_hsa052220.55399748
100Pentose phosphate pathway_Homo sapiens_hsa000300.54638160
101Folate biosynthesis_Homo sapiens_hsa007900.52634097
102Amoebiasis_Homo sapiens_hsa051460.52620450
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51769734
104Tryptophan metabolism_Homo sapiens_hsa003800.51276639
105Tyrosine metabolism_Homo sapiens_hsa003500.51024248
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48640474
107Galactose metabolism_Homo sapiens_hsa000520.47772964
108Purine metabolism_Homo sapiens_hsa002300.46428765
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46400005
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44368459
111Viral carcinogenesis_Homo sapiens_hsa052030.43647742
112VEGF signaling pathway_Homo sapiens_hsa043700.43569376
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43537925
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42734078
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41942640
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41887354
117Calcium signaling pathway_Homo sapiens_hsa040200.41546710
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41015014
119Steroid biosynthesis_Homo sapiens_hsa001000.40957243
120PPAR signaling pathway_Homo sapiens_hsa033200.40103253
121Starch and sucrose metabolism_Homo sapiens_hsa005000.39819600
122Alcoholism_Homo sapiens_hsa050340.39184450
123Endometrial cancer_Homo sapiens_hsa052130.38219509
124Arginine and proline metabolism_Homo sapiens_hsa003300.37895888
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37238940
126Melanoma_Homo sapiens_hsa052180.36738499
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36630366
128AMPK signaling pathway_Homo sapiens_hsa041520.34777687
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33637997
130ErbB signaling pathway_Homo sapiens_hsa040120.32811990
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32613735
132Fructose and mannose metabolism_Homo sapiens_hsa000510.31449680
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.29465279
134HIF-1 signaling pathway_Homo sapiens_hsa040660.28727139
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.28591190
136Glutathione metabolism_Homo sapiens_hsa004800.28367639
137N-Glycan biosynthesis_Homo sapiens_hsa005100.28095131
138Linoleic acid metabolism_Homo sapiens_hsa005910.25538653
139Renin-angiotensin system_Homo sapiens_hsa046140.23346098
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.23020496

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