PITX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1skeletal muscle fiber development (GO:0048741)9.53943805
2muscle cell fate commitment (GO:0042693)9.38399552
3sarcoplasmic reticulum calcium ion transport (GO:0070296)9.04808629
4actin-mediated cell contraction (GO:0070252)8.84557695
5regulation of skeletal muscle contraction (GO:0014819)8.52757215
6myotube cell development (GO:0014904)8.24134617
7positive regulation of myotube differentiation (GO:0010831)7.24982479
8myotube differentiation (GO:0014902)6.65971474
9striated muscle contraction (GO:0006941)6.65925785
10response to inactivity (GO:0014854)6.64576706
11response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.53988890
12dopamine biosynthetic process (GO:0042416)6.41644381
13alkaloid metabolic process (GO:0009820)6.37670933
14pyrimidine nucleobase catabolic process (GO:0006208)6.37282290
15actin filament-based movement (GO:0030048)6.33963644
16regulation of cell-cell adhesion mediated by cadherin (GO:2000047)6.19958157
17* lens development in camera-type eye (GO:0002088)6.14820703
18creatine metabolic process (GO:0006600)6.07081062
19muscle fiber development (GO:0048747)5.76645684
20myofibril assembly (GO:0030239)5.63412884
21L-phenylalanine catabolic process (GO:0006559)5.49603746
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.49603746
23epithelial cell differentiation involved in prostate gland development (GO:0060742)5.48476935
24lens fiber cell development (GO:0070307)5.48332272
25sarcomere organization (GO:0045214)5.46805876
26regulation of relaxation of muscle (GO:1901077)5.36645440
27muscle contraction (GO:0006936)5.15673192
28plasma membrane repair (GO:0001778)5.09034086
29dopamine transport (GO:0015872)5.08120868
30bile acid and bile salt transport (GO:0015721)5.07994966
31skeletal muscle tissue development (GO:0007519)5.06441785
32nucleobase catabolic process (GO:0046113)5.02085565
33L-phenylalanine metabolic process (GO:0006558)5.00870732
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.00870732
35aromatic amino acid family catabolic process (GO:0009074)4.94294261
36striated muscle atrophy (GO:0014891)4.94182849
37bile acid biosynthetic process (GO:0006699)4.73503204
38cytolysis (GO:0019835)4.70454599
39regulation of somitogenesis (GO:0014807)4.68990168
40glyoxylate metabolic process (GO:0046487)4.68314277
41positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.67406328
42kynurenine metabolic process (GO:0070189)4.63878003
43muscle atrophy (GO:0014889)4.62739838
44muscle system process (GO:0003012)4.61319728
45indolalkylamine metabolic process (GO:0006586)4.57422741
46cardiac muscle contraction (GO:0060048)4.56664063
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.55569150
48response to insecticide (GO:0017085)4.54766718
49ethanol oxidation (GO:0006069)4.53806371
50coenzyme catabolic process (GO:0009109)4.52988095
51urea cycle (GO:0000050)4.52822413
52urea metabolic process (GO:0019627)4.52822413
53glycogen biosynthetic process (GO:0005978)4.47520153
54glucan biosynthetic process (GO:0009250)4.47520153
55indole-containing compound catabolic process (GO:0042436)4.47152415
56indolalkylamine catabolic process (GO:0046218)4.47152415
57tryptophan catabolic process (GO:0006569)4.47152415
58skeletal muscle adaptation (GO:0043501)4.43298988
59striated muscle cell development (GO:0055002)4.37672828
60* dopaminergic neuron differentiation (GO:0071542)4.33513371
61negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.32345492
62alpha-linolenic acid metabolic process (GO:0036109)4.29306331
63complement activation, alternative pathway (GO:0006957)4.28271279
64cardiac myofibril assembly (GO:0055003)4.26219725
65nitrogen cycle metabolic process (GO:0071941)4.25873015
66neuromuscular synaptic transmission (GO:0007274)4.20709393
67tyrosine metabolic process (GO:0006570)4.20226347
68muscle organ development (GO:0007517)4.17335946
69muscle structure development (GO:0061061)4.13094334
70glycogen catabolic process (GO:0005980)4.11643342
71positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)4.05604243
72negative regulation of fibrinolysis (GO:0051918)4.02886950
73muscle organ morphogenesis (GO:0048644)4.00284492
74regulation of protein activation cascade (GO:2000257)3.98975877
75tryptophan metabolic process (GO:0006568)3.98793629
76skeletal muscle tissue regeneration (GO:0043403)3.98275108
77regulation of fibrinolysis (GO:0051917)3.97961352
78actomyosin structure organization (GO:0031032)3.97862475
79striated muscle adaptation (GO:0014888)3.96327672
80catecholamine biosynthetic process (GO:0042423)3.90574103
81catechol-containing compound biosynthetic process (GO:0009713)3.90574103
82acetyl-CoA metabolic process (GO:0006084)3.90258467
83regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.87886028
84triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.87336744
85negative regulation of microtubule polymerization (GO:0031115)3.84228197
86muscle cell development (GO:0055001)3.83583218
87cellular ketone body metabolic process (GO:0046950)3.83473483
88glucan catabolic process (GO:0009251)3.81852132
89muscle cell cellular homeostasis (GO:0046716)3.78739804
90negative regulation of potassium ion transmembrane transport (GO:1901380)3.78011467
91bile acid metabolic process (GO:0008206)3.75929455
92regulation of complement activation (GO:0030449)3.74897048
93regulation of actin filament-based movement (GO:1903115)3.74388639
94aromatic amino acid family metabolic process (GO:0009072)3.73308048
95fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.67774090
96sulfur amino acid catabolic process (GO:0000098)3.66412887
97regulation of myotube differentiation (GO:0010830)3.62531020
98regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.62482858
99regulation of dopamine metabolic process (GO:0042053)3.60955944
100regulation of catecholamine metabolic process (GO:0042069)3.60955944
101muscle tissue morphogenesis (GO:0060415)3.56864333
102catecholamine transport (GO:0051937)3.56626980
103positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.55895369
104response to activity (GO:0014823)3.55501506
105cysteine metabolic process (GO:0006534)3.55091605
106protein carboxylation (GO:0018214)3.51481255
107peptidyl-glutamic acid carboxylation (GO:0017187)3.51481255
108serine family amino acid catabolic process (GO:0009071)3.50729937
109positive regulation of myoblast differentiation (GO:0045663)3.50690061
110striated muscle tissue development (GO:0014706)3.50410508
111myoblast fusion (GO:0007520)3.50248177
112cellular polysaccharide catabolic process (GO:0044247)3.49394010
113fatty acid elongation (GO:0030497)3.45725736
114dorsal/ventral neural tube patterning (GO:0021904)3.44861717
115positive regulation of striated muscle cell differentiation (GO:0051155)3.42808679
116imidazole-containing compound metabolic process (GO:0052803)3.41944440
117regulation of cell communication by electrical coupling (GO:0010649)3.41692359
118regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.41669712
119homocysteine metabolic process (GO:0050667)3.39576637
120positive regulation of skeletal muscle tissue development (GO:0048643)3.36549013
121regulation of striated muscle contraction (GO:0006942)3.32992804
122alpha-amino acid catabolic process (GO:1901606)3.32747799
123aldehyde catabolic process (GO:0046185)3.32389652
124indole-containing compound metabolic process (GO:0042430)3.29179559
125NADH metabolic process (GO:0006734)3.29058631
126glutamate metabolic process (GO:0006536)3.28655521
127ketone body metabolic process (GO:1902224)3.27030661
128high-density lipoprotein particle remodeling (GO:0034375)3.26985699
129glycogen metabolic process (GO:0005977)3.26498627
130arginine metabolic process (GO:0006525)3.26172608
131lysine catabolic process (GO:0006554)3.24069403
132lysine metabolic process (GO:0006553)3.24069403
133cardiac muscle tissue morphogenesis (GO:0055008)3.23828647
134acylglycerol homeostasis (GO:0055090)3.22344455
135triglyceride homeostasis (GO:0070328)3.22344455
136regulation of skeletal muscle cell differentiation (GO:2001014)3.21016932
137benzene-containing compound metabolic process (GO:0042537)3.20653546
138glucan metabolic process (GO:0044042)3.18483822
139cellular glucan metabolic process (GO:0006073)3.18483822
140regulation of myoblast differentiation (GO:0045661)3.17026442
141neurotransmitter biosynthetic process (GO:0042136)3.16795354
142dicarboxylic acid biosynthetic process (GO:0043650)3.15927177
143response to muscle activity (GO:0014850)3.15297416
144muscle adaptation (GO:0043500)3.14406855
145regulation of triglyceride catabolic process (GO:0010896)3.13978631
146polysaccharide catabolic process (GO:0000272)3.13279295
147cellular biogenic amine catabolic process (GO:0042402)3.11290212
148amine catabolic process (GO:0009310)3.11290212
149cardiac muscle cell development (GO:0055013)3.10719233
150cellular amino acid catabolic process (GO:0009063)3.08703079
151cellular response to estradiol stimulus (GO:0071392)3.07077251
152muscle tissue development (GO:0060537)3.06049004
153ethanol metabolic process (GO:0006067)3.05581785
154cardiac muscle hypertrophy (GO:0003300)3.04629714
155ubiquinone biosynthetic process (GO:0006744)3.04213192
156syncytium formation by plasma membrane fusion (GO:0000768)3.04136697
157cellular modified amino acid catabolic process (GO:0042219)3.03684554
158regulation of plasminogen activation (GO:0010755)3.02260265
159fatty acid transmembrane transport (GO:1902001)2.98554626
160amino-acid betaine metabolic process (GO:0006577)2.98546467
161cofactor catabolic process (GO:0051187)2.95957018
162midgut development (GO:0007494)2.95503902
163plasma lipoprotein particle remodeling (GO:0034369)2.93923012
164protein-lipid complex remodeling (GO:0034368)2.93923012
165macromolecular complex remodeling (GO:0034367)2.93923012
166gluconeogenesis (GO:0006094)2.93649709
167skeletal muscle cell differentiation (GO:0035914)2.93162097
168regulation of dopamine secretion (GO:0014059)2.92793436
169IMP metabolic process (GO:0046040)2.92757842
170striated muscle hypertrophy (GO:0014897)2.91177495
171negative regulation of calcium ion transmembrane transport (GO:1903170)2.89019036
172negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.89019036
173neuron cell-cell adhesion (GO:0007158)2.88896521
174carnitine shuttle (GO:0006853)2.88469861
175phospholipid efflux (GO:0033700)2.87207972
176positive regulation of muscle cell differentiation (GO:0051149)2.85160704
177linoleic acid metabolic process (GO:0043651)2.85096894
178mating behavior (GO:0007617)2.84113200
179glycine metabolic process (GO:0006544)2.83495384
1802-oxoglutarate metabolic process (GO:0006103)2.83024763
181cardiac cell development (GO:0055006)2.81160348
182adult heart development (GO:0007512)2.81133493
183regulation of sequestering of triglyceride (GO:0010889)2.80416755
184response to cocaine (GO:0042220)2.79603086
185regulation of secondary heart field cardioblast proliferation (GO:0003266)2.78463665
186regulation of cardioblast proliferation (GO:0003264)2.78463665
187very long-chain fatty acid metabolic process (GO:0000038)2.76797481
188regulation of bile acid biosynthetic process (GO:0070857)2.76406752
189ubiquinone metabolic process (GO:0006743)2.73689428
190negative regulation of muscle contraction (GO:0045932)2.73165553
191regulation of calcium ion transmembrane transport (GO:1903169)2.67937076
192regulation of calcium ion transmembrane transporter activity (GO:1901019)2.67937076
193positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.67740159
194kidney mesenchyme development (GO:0072074)2.67090356
195oxidative phosphorylation (GO:0006119)2.65380675
196muscle filament sliding (GO:0030049)10.8191907
197actin-myosin filament sliding (GO:0033275)10.8191907
198skeletal muscle contraction (GO:0003009)10.1530122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.29353712
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.05835286
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.67820503
4ZNF263_19887448_ChIP-Seq_K562_Human3.44463463
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.37927098
6EZH2_22144423_ChIP-Seq_EOC_Human3.34284465
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.17916186
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12157149
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.02288212
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91884088
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55360014
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27316408
13* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22956822
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.22149944
15* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20075306
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17744260
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17533828
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.15284354
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07155303
20* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05111984
21* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02005767
22* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02005767
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01225180
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97446198
25BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.91227097
26TAF15_26573619_Chip-Seq_HEK293_Human1.90526893
27* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89390024
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86260668
29STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.82247210
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.82161516
31* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.81641354
32* EED_16625203_ChIP-ChIP_MESCs_Mouse1.80424274
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.79731575
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.79137231
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78034047
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.76895478
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.74278337
38VDR_22108803_ChIP-Seq_LS180_Human1.74075532
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.72745227
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.72745227
41NFIB_24661679_ChIP-Seq_LUNG_Mouse1.69782474
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66264660
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64714843
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.63399227
45NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.62469539
46DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60876672
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.60576158
48* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59956319
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.59013809
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.58933745
51GBX2_23144817_ChIP-Seq_PC3_Human1.53842452
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49217527
53SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.49166226
54* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48617451
55HTT_18923047_ChIP-ChIP_STHdh_Human1.44366956
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44128168
57ZNF274_21170338_ChIP-Seq_K562_Hela1.43158752
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40559239
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40030114
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.39613446
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.37671741
62MYC_27129775_Chip-Seq_CORNEA_Mouse1.36276282
63* LXR_22292898_ChIP-Seq_THP-1_Human1.36152546
64CTCF_21964334_Chip-Seq_Bcells_Human1.30875544
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30580487
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29966321
67REST_21632747_ChIP-Seq_MESCs_Mouse1.28810715
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27753806
69AR_21572438_ChIP-Seq_LNCaP_Human1.24826126
70CTCF_27219007_Chip-Seq_Bcells_Human1.24179360
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.23981512
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.23583776
73EGR1_19032775_ChIP-ChIP_M12_Human1.23324923
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22590071
75XRN2_22483619_ChIP-Seq_HELA_Human1.19619886
76CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19012949
77DROSHA_22980978_ChIP-Seq_HELA_Human1.17691662
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.16569145
79KDM2B_26808549_Chip-Seq_DND41_Human1.16340002
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16180681
81EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16063655
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.15480120
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.15442098
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14984430
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14827352
86CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13211260
87P68_20966046_ChIP-Seq_HELA_Human1.11841444
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11454954
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10968361
90NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10656107
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10466887
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10462233
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08486581
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07710840
95RBPJ_22232070_ChIP-Seq_NCS_Mouse1.07665466
96* SA1_27219007_Chip-Seq_Bcells_Human1.06668637
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06269267
98* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05790918
99RING1B_27294783_Chip-Seq_NPCs_Mouse1.05468123
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.04669369
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04410703
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.04292627
103GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03548870
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02600991
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00961455
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00603744
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.00031223
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98760679
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98760679
110ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96479708
111RACK7_27058665_Chip-Seq_MCF-7_Human0.96337363
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96196338
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95598546
114ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94897315
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.94508998
116BCAT_22108803_ChIP-Seq_LS180_Human0.93410331
117TRIM28_21343339_ChIP-Seq_HEK293_Human0.93051292
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92349002
119SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91661010
120MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.91387169
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91053066
122RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90962912
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89448260
124CLOCK_20551151_ChIP-Seq_293T_Human0.88719208
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88679167
126ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87901404
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87175547
128RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86893963
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86591016
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86469000
131TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86251263
132NFI_21473784_ChIP-Seq_ESCs_Mouse0.83649377
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.83465455
134IGF1R_20145208_ChIP-Seq_DFB_Human0.83437340
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82914059
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82215519
137SOX2_21211035_ChIP-Seq_LN229_Gbm0.81235527
138FOXA2_19822575_ChIP-Seq_HepG2_Human0.80900910
139SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80795621
140IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80146986
141CBP_20019798_ChIP-Seq_JUKART_Human0.80146986
142DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79573478
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.78624672
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78179513
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77071494
146* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76300876
147SUZ12_27294783_Chip-Seq_NPCs_Mouse0.75996044
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74723284
149ESR2_21235772_ChIP-Seq_MCF-7_Human0.73935100
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72403819
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.71513631
152RNF2_27304074_Chip-Seq_NSC_Mouse0.71097852
153P300_19829295_ChIP-Seq_ESCs_Human0.70923420
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.70792083
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68806468
156NFE2_27457419_Chip-Seq_LIVER_Mouse0.67595872
157KDM2B_26808549_Chip-Seq_K562_Human0.66601968
158NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65905532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.19387343
2MP0000569_abnormal_digit_pigmentation5.46313700
3MP0005360_urolithiasis4.53343907
4MP0005085_abnormal_gallbladder_physiolo4.31324438
5MP0005365_abnormal_bile_salt3.88756736
6MP0000733_abnormal_muscle_development3.79275788
7MP0004036_abnormal_muscle_relaxation3.58844703
8* MP0002697_abnormal_eye_size3.18301856
9MP0004233_abnormal_muscle_weight3.08989710
10MP0003252_abnormal_bile_duct2.80939991
11MP0002909_abnormal_adrenal_gland2.70447633
12MP0005083_abnormal_biliary_tract2.61660610
13MP0008875_abnormal_xenobiotic_pharmacok2.57283625
14MP0006276_abnormal_autonomic_nervous2.44887225
15MP0010329_abnormal_lipoprotein_level2.44148257
16MP0009379_abnormal_foot_pigmentation2.43748828
17MP0004084_abnormal_cardiac_muscle2.43372074
18* MP0001905_abnormal_dopamine_level2.33034008
19MP0000751_myopathy2.24125776
20MP0003880_abnormal_central_pattern2.07256309
21* MP0005193_abnormal_anterior_eye1.97410392
22MP0002837_dystrophic_cardiac_calcinosis1.95831826
23MP0000749_muscle_degeneration1.95623723
24MP0003283_abnormal_digestive_organ1.92942865
25MP0000566_synostosis1.86754793
26MP0003868_abnormal_feces_composition1.77823449
27MP0004215_abnormal_myocardial_fiber1.68398600
28MP0003806_abnormal_nucleotide_metabolis1.66067108
29MP0002972_abnormal_cardiac_muscle1.63519666
30MP0006035_abnormal_mitochondrial_morpho1.59114720
31MP0005220_abnormal_exocrine_pancreas1.57760302
32MP0005670_abnormal_white_adipose1.56121024
33MP0010030_abnormal_orbit_morphology1.55558903
34MP0001666_abnormal_nutrient_absorption1.52874357
35MP0000747_muscle_weakness1.35896791
36MP0005332_abnormal_amino_acid1.34663650
37MP0004270_analgesia1.32709804
38MP0003195_calcinosis1.31687066
39MP0010630_abnormal_cardiac_muscle1.28627707
40MP0002234_abnormal_pharynx_morphology1.27703439
41MP0000013_abnormal_adipose_tissue1.27524758
42MP0004145_abnormal_muscle_electrophysio1.27004435
43MP0001529_abnormal_vocalization1.25582650
44MP0003137_abnormal_impulse_conducting1.23266434
45MP0002127_abnormal_cardiovascular_syste1.22315111
46MP0004185_abnormal_adipocyte_glucose1.20851924
47MP0002269_muscular_atrophy1.20477684
48* MP0002118_abnormal_lipid_homeostasis1.20329525
49MP0002108_abnormal_muscle_morphology1.20251187
50MP0004859_abnormal_synaptic_plasticity1.19099175
51MP0002332_abnormal_exercise_endurance1.16584497
52MP0006138_congestive_heart_failure1.15836955
53MP0002184_abnormal_innervation1.09645109
54MP0000778_abnormal_nervous_system1.07983872
55* MP0000609_abnormal_liver_physiology1.06967471
56MP0005409_darkened_coat_color1.06173139
57MP0003942_abnormal_urinary_system1.04800621
58MP0001661_extended_life_span1.03310837
59* MP0005197_abnormal_uvea_morphology1.03241468
60MP0003136_yellow_coat_color1.02516246
61MP0004858_abnormal_nervous_system1.02489321
62MP0003635_abnormal_synaptic_transmissio1.00888958
63MP0000759_abnormal_skeletal_muscle0.99214714
64MP0000003_abnormal_adipose_tissue0.97800570
65* MP0005535_abnormal_body_temperature0.96584218
66MP0005666_abnormal_adipose_tissue0.95498512
67MP0003879_abnormal_hair_cell0.95312292
68MP0005385_cardiovascular_system_phenoty0.95258757
69MP0001544_abnormal_cardiovascular_syste0.95258757
70MP0000579_abnormal_nail_morphology0.94161181
71MP0002138_abnormal_hepatobiliary_system0.92874267
72MP0005375_adipose_tissue_phenotype0.92402292
73MP0003221_abnormal_cardiomyocyte_apopto0.91504217
74MP0005187_abnormal_penis_morphology0.90919915
75MP0002638_abnormal_pupillary_reflex0.89676140
76MP0004484_altered_response_of0.89623893
77MP0005248_abnormal_Harderian_gland0.88989571
78MP0004019_abnormal_vitamin_homeostasis0.88977083
79MP0005369_muscle_phenotype0.88940029
80MP0002090_abnormal_vision0.88591893
81MP0004087_abnormal_muscle_fiber0.88173606
82MP0000538_abnormal_urinary_bladder0.85761005
83MP0008961_abnormal_basal_metabolism0.85381970
84MP0005423_abnormal_somatic_nervous0.85184474
85MP0004883_abnormal_blood_vessel0.85044179
86MP0009840_abnormal_foam_cell0.84385304
87MP0009250_abnormal_appendicular_skeleto0.83478148
88MP0004130_abnormal_muscle_cell0.81979774
89MP0005266_abnormal_metabolism0.80795670
90* MP0005319_abnormal_enzyme/_coenzyme0.80416381
91MP0002653_abnormal_ependyma_morphology0.79745351
92MP0002106_abnormal_muscle_physiology0.79211720
93MP0009053_abnormal_anal_canal0.78705442
94MP0002163_abnormal_gland_morphology0.77183053
95MP0005253_abnormal_eye_physiology0.76826753
96MP0004924_abnormal_behavior0.76790764
97MP0005386_behavior/neurological_phenoty0.76790764
98MP0003705_abnormal_hypodermis_morpholog0.76683198
99MP0002971_abnormal_brown_adipose0.75494940
100MP0002249_abnormal_larynx_morphology0.75208549
101MP0000750_abnormal_muscle_regeneration0.74876987
102MP0005584_abnormal_enzyme/coenzyme_acti0.74316918
103MP0006036_abnormal_mitochondrial_physio0.73870601
104MP0002067_abnormal_sensory_capabilities0.73150050
105MP0005620_abnormal_muscle_contractility0.72253810
106* MP0001286_abnormal_eye_development0.72110202
107MP0005623_abnormal_meninges_morphology0.71993006
108MP0002822_catalepsy0.71150587
109MP0000762_abnormal_tongue_morphology0.68923956
110MP0002114_abnormal_axial_skeleton0.68875978
111MP0003950_abnormal_plasma_membrane0.68628686
112MP0001188_hyperpigmentation0.67202274
113MP0000049_abnormal_middle_ear0.66696554
114* MP0003959_abnormal_lean_body0.66008659
115MP0000462_abnormal_digestive_system0.65461576
116MP0005330_cardiomyopathy0.65005101
117MP0002751_abnormal_autonomic_nervous0.64059265
118MP0002177_abnormal_outer_ear0.63807244
119MP0005376_homeostasis/metabolism_phenot0.63047406
120* MP0002063_abnormal_learning/memory/cond0.62755782
121MP0001440_abnormal_grooming_behavior0.60432415
122MP0002277_abnormal_respiratory_mucosa0.59960751
123MP0003646_muscle_fatigue0.58975456
124MP0003123_paternal_imprinting0.57563781
125MP0005451_abnormal_body_composition0.55534173
126MP0002064_seizures0.55045906
127MP0002932_abnormal_joint_morphology0.54943289
128MP0003122_maternal_imprinting0.54764135
129* MP0002066_abnormal_motor_capabilities/c0.54344094
130MP0005084_abnormal_gallbladder_morpholo0.54171936
131MP0002078_abnormal_glucose_homeostasis0.53964100
132* MP0002572_abnormal_emotion/affect_behav0.53661174
133MP0001486_abnormal_startle_reflex0.53198636
134MP0000678_abnormal_parathyroid_gland0.53089465
135MP0004134_abnormal_chest_morphology0.53063013
136MP0004142_abnormal_muscle_tone0.52989065
137MP0004085_abnormal_heartbeat0.52527240
138MP0002796_impaired_skin_barrier0.52422327
139MP0004510_myositis0.52059528
140* MP0001340_abnormal_eyelid_morphology0.51841692
141* MP0001346_abnormal_lacrimal_gland0.51371353
142MP0004043_abnormal_pH_regulation0.51106654
143MP0000534_abnormal_ureter_morphology0.49989217
144MP0000266_abnormal_heart_morphology0.49474819
145MP0008775_abnormal_heart_ventricle0.49450642
146* MP0002734_abnormal_mechanical_nocicepti0.49268062
147MP0003632_abnormal_nervous_system0.49227464
148* MP0001943_abnormal_respiration0.48239609
149MP0003385_abnormal_body_wall0.45734283
150MP0003938_abnormal_ear_development0.43458780
151MP0002081_perinatal_lethality0.43209619
152MP0001879_abnormal_lymphatic_vessel0.42908835
153MP0004197_abnormal_fetal_growth/weight/0.41054474
154MP0004133_heterotaxia0.39095153
155MP0009672_abnormal_birth_weight0.38344972
156MP0000631_abnormal_neuroendocrine_gland0.38070175
157MP0003948_abnormal_gas_homeostasis0.35586070
158MP0002938_white_spotting0.35465832
159MP0003755_abnormal_palate_morphology0.34835557
160MP0002160_abnormal_reproductive_system0.34133095
161MP0002116_abnormal_craniofacial_bone0.33231825

Predicted human phenotypes

RankGene SetZ-score
1Myopathic facies (HP:0002058)6.47684646
2Limb dystonia (HP:0002451)4.93081408
3Ulnar deviation of the wrist (HP:0003049)4.86231467
4Calcaneovalgus deformity (HP:0001848)4.66912882
5Intrahepatic cholestasis (HP:0001406)4.59559953
6Aplasia of the musculature (HP:0100854)4.43268696
7Deep venous thrombosis (HP:0002625)4.38425342
8Amblyopia (HP:0000646)4.30308543
9Deformed tarsal bones (HP:0008119)4.11827173
10Hypobetalipoproteinemia (HP:0003563)4.10253824
11Congenital cataract (HP:0000519)4.03314783
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.02693121
13Neck muscle weakness (HP:0000467)3.95498023
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.91864333
15Xanthomatosis (HP:0000991)3.87331926
16Abnormality of skeletal muscle fiber size (HP:0012084)3.82512628
17Subaortic stenosis (HP:0001682)3.77173310
18Abnormality of the left ventricular outflow tract (HP:0011103)3.77173310
19Prolonged partial thromboplastin time (HP:0003645)3.74360969
20Complement deficiency (HP:0004431)3.70702946
21Muscle fiber inclusion bodies (HP:0100299)3.60896594
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.60147257
23Rimmed vacuoles (HP:0003805)3.44264989
24Increased connective tissue (HP:0009025)3.39740375
25Absent phalangeal crease (HP:0006109)3.38533514
26Abnormality of placental membranes (HP:0011409)3.30045820
27Amniotic constriction ring (HP:0009775)3.30045820
28Nemaline bodies (HP:0003798)3.29034509
29Abnormality of monocarboxylic acid metabolism (HP:0010996)3.25703176
30Fatigable weakness (HP:0003473)3.20230597
31Abnormality of the neuromuscular junction (HP:0003398)3.20230597
32Epidermoid cyst (HP:0200040)3.13041811
33Weak cry (HP:0001612)3.12750236
34Myotonia (HP:0002486)3.12312229
35Increased variability in muscle fiber diameter (HP:0003557)3.11956733
36Muscle stiffness (HP:0003552)3.11221181
37Corneal dystrophy (HP:0001131)3.08033526
38Fetal akinesia sequence (HP:0001989)3.06458991
39Slender build (HP:0001533)2.98564149
40Asymmetric septal hypertrophy (HP:0001670)2.97780308
41Hypolipoproteinemia (HP:0010981)2.97094457
42Abnormal finger flexion creases (HP:0006143)2.93163508
43Type 2 muscle fiber atrophy (HP:0003554)2.92156161
44Sudden death (HP:0001699)2.91414226
45Abnormal pupillary function (HP:0007686)2.87482163
46Bulbar palsy (HP:0001283)2.86270649
47Ketosis (HP:0001946)2.84917258
48Frequent falls (HP:0002359)2.83920435
49Generalized muscle weakness (HP:0003324)2.83679678
50Muscle fiber atrophy (HP:0100295)2.82389002
51Muscle hypertrophy of the lower extremities (HP:0008968)2.79240872
52Aplasia/Hypoplasia involving the musculature (HP:0001460)2.78914088
53Gowers sign (HP:0003391)2.78098227
54Mildly elevated creatine phosphokinase (HP:0008180)2.76969194
55Distal lower limb muscle weakness (HP:0009053)2.72845959
56Joint hemorrhage (HP:0005261)2.72398282
57Hyperlipoproteinemia (HP:0010980)2.71100724
58Exercise-induced myalgia (HP:0003738)2.69187216
59Abnormality of the calcaneus (HP:0008364)2.67894859
60Abnormality of complement system (HP:0005339)2.66343911
61Progressive muscle weakness (HP:0003323)2.65641727
62Fat malabsorption (HP:0002630)2.59097638
63Calf muscle hypertrophy (HP:0008981)2.53936990
64Hyperglycinemia (HP:0002154)2.52830000
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52370160
66Areflexia of lower limbs (HP:0002522)2.48301978
67Hyperammonemia (HP:0001987)2.46212030
68EMG: neuropathic changes (HP:0003445)2.45301639
69Hypoalphalipoproteinemia (HP:0003233)2.44816994
70Limb-girdle muscle atrophy (HP:0003797)2.44237971
71Type 1 muscle fiber predominance (HP:0003803)2.42105730
72Hip contracture (HP:0003273)2.40520351
73Distal arthrogryposis (HP:0005684)2.40409272
74Popliteal pterygium (HP:0009756)2.36791202
75Cerebral edema (HP:0002181)2.35183671
76Malignant hyperthermia (HP:0002047)2.34840050
77Hyporeflexia of lower limbs (HP:0002600)2.33572790
78Akinesia (HP:0002304)2.31088878
79Skin nodule (HP:0200036)2.27870234
80Muscle fiber splitting (HP:0003555)2.27868028
81Bundle branch block (HP:0011710)2.27123431
82Hypothermia (HP:0002045)2.27104000
83Scapular winging (HP:0003691)2.24466711
84Abnormality of glycine metabolism (HP:0010895)2.23803212
85Abnormality of serine family amino acid metabolism (HP:0010894)2.23803212
86Distal lower limb amyotrophy (HP:0008944)2.23795784
87Hyperglycinuria (HP:0003108)2.22277394
88Round ear (HP:0100830)2.19586573
89Abnormal gallbladder physiology (HP:0012438)2.18437922
90Cholecystitis (HP:0001082)2.18437922
91Respiratory insufficiency due to muscle weakness (HP:0002747)2.17803538
92Dilated cardiomyopathy (HP:0001644)2.16864196
93Short palpebral fissure (HP:0012745)2.12660199
94Difficulty running (HP:0009046)2.12258019
95Ragged-red muscle fibers (HP:0003200)2.11982145
96Increased intramyocellular lipid droplets (HP:0012240)2.09711060
97Shoulder girdle muscle weakness (HP:0003547)2.08702744
98Thin ribs (HP:0000883)2.07255523
99* Anterior segment dysgenesis (HP:0007700)2.06403454
100Abnormality of the common coagulation pathway (HP:0010990)2.05614393
101Spinal rigidity (HP:0003306)2.04887921
102Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04094313
103Glomerulonephritis (HP:0000099)2.03925002
104Myoglobinuria (HP:0002913)2.02912864
105Rhabdomyolysis (HP:0003201)2.00944096
106Ketoacidosis (HP:0001993)2.00831051
107Nuclear cataract (HP:0100018)13.1026963
108Zonular cataract (HP:0010920)11.4144088
109Ventricular tachycardia (HP:0004756)1.97603821
110Lipoatrophy (HP:0100578)1.94558933
111Exercise-induced muscle cramps (HP:0003710)1.94104219
112Acute encephalopathy (HP:0006846)1.91781923
113Waddling gait (HP:0002515)1.89527885
114Morphological abnormality of the pyramidal tract (HP:0002062)1.88975158
115Poor suck (HP:0002033)1.87944664
116Cortical dysplasia (HP:0002539)1.87545736
117* Polar cataract (HP:0010696)1.85767116
118Nonprogressive disorder (HP:0003680)1.85400588
119Neonatal onset (HP:0003623)1.83410835
120Easy fatigability (HP:0003388)1.82554022
121Long clavicles (HP:0000890)1.81759759
122Increased muscle lipid content (HP:0009058)1.81195135
123Microcornea (HP:0000482)1.80676896
124Morphological abnormality of the middle ear (HP:0008609)1.80145332
125Abnormality of the intrinsic pathway (HP:0010989)1.79405675
126Exercise intolerance (HP:0003546)1.78973291
127Metatarsus adductus (HP:0001840)1.77828704
128Wrist flexion contracture (HP:0001239)1.77507796
129Steatorrhea (HP:0002570)1.77484421
130Abnormality of the shoulder girdle musculature (HP:0001435)1.76950117
131Abnormality of the calf musculature (HP:0001430)1.76626717
132Hypercholesterolemia (HP:0003124)1.75714254
133EMG: myopathic abnormalities (HP:0003458)1.74914440
134Abnormality of sulfur amino acid metabolism (HP:0004339)1.74640512
135Hyperkalemia (HP:0002153)1.74051460
136Abnormality of the Achilles tendon (HP:0005109)1.73363913
137Gout (HP:0001997)1.72533747
138Cerebral inclusion bodies (HP:0100314)1.72116590
139Hypoplastic heart (HP:0001961)1.72059365
140Abnormality of the axillary hair (HP:0100134)1.71550064
141Abnormality of secondary sexual hair (HP:0009888)1.71550064
142Pterygium (HP:0001059)1.71521281
143Pelvic girdle muscle weakness (HP:0003749)1.71148202
144Abnormality of the foot musculature (HP:0001436)1.71066514
145Abnormal gallbladder morphology (HP:0012437)1.70626692
146Difficulty climbing stairs (HP:0003551)1.70509424
147Visual hallucinations (HP:0002367)1.70402647
148Lipid accumulation in hepatocytes (HP:0006561)1.70122207
149Cholelithiasis (HP:0001081)1.69744232
150Conjugated hyperbilirubinemia (HP:0002908)1.68738768
151Late onset (HP:0003584)1.67645460
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66730448
153Proximal amyotrophy (HP:0007126)1.66462561
154Acute necrotizing encephalopathy (HP:0006965)1.65772458
155Adducted thumb (HP:0001181)1.64279348
156Diminished movement (HP:0002374)1.63469129
157Concave nail (HP:0001598)1.62857493
158Abnormality of the parathyroid morphology (HP:0011766)1.61709650
159Lethargy (HP:0001254)1.60217609
160Ulnar deviation of finger (HP:0009465)1.57634350
161Heart block (HP:0012722)1.56524609
162Lower limb amyotrophy (HP:0007210)1.56245347
163Limb-girdle muscle weakness (HP:0003325)1.56095464
164Foot dorsiflexor weakness (HP:0009027)1.55025318
165Muscular dystrophy (HP:0003560)1.52934954
166Facial diplegia (HP:0001349)1.50647609
167Limited hip movement (HP:0008800)1.50333610
168Double outlet right ventricle (HP:0001719)1.49317254
169Congenital malformation of the right heart (HP:0011723)1.49317254
170Abnormal atrioventricular conduction (HP:0005150)1.48739298
171Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.42879938
172Generalized amyotrophy (HP:0003700)1.41240995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR43.10259233
2MARK13.06060790
3FGFR22.89342399
4GRK62.80772205
5CASK2.55381687
6PHKG12.43947667
7PHKG22.43947667
8CSNK1G32.40947428
9PNCK2.40903314
10OBSCN2.40387008
11MAP2K42.22398407
12IRAK22.19671902
13ERBB42.10637986
14CSNK1G12.04863105
15PIK3CG1.99104854
16CSNK1G21.90687243
17NTRK21.88694128
18GRK51.85205401
19MAPK131.82185530
20MAP2K31.79097110
21TYRO31.73494385
22SIK11.66260369
23EEF2K1.61846249
24LATS21.60085813
25TRIB31.56130123
26FGR1.49469093
27TTN1.46858298
28MAP2K61.42265469
29UHMK11.41883716
30LATS11.39415274
31MAPKAPK51.32446258
32PDGFRA1.29121289
33MINK11.28943586
34BCKDK1.28585838
35CCNB11.26668758
36MAP3K101.24561416
37PAK61.24405806
38PAK31.23727730
39MOS1.18099626
40NME11.17103784
41DYRK21.09494068
42MAPK121.07686176
43MAP3K121.06715716
44DYRK1B1.05638443
45NEK11.03121921
46MAP2K11.01998858
47PKN10.97145610
48BCR0.96413265
49CSNK1A1L0.96021343
50RIPK10.95881747
51PDK20.95839711
52RET0.95653541
53MAPK40.95205906
54FGFR10.94704775
55MAP3K40.94192809
56CDK80.87172975
57DDR20.86771615
58ADRBK10.85058762
59ERN10.83846398
60CDK180.83697773
61CDK150.82634178
62PTK20.80571166
63MAP2K70.79317995
64PLK20.77842326
65PTK2B0.76482722
66DYRK1A0.76353484
67PTK60.75173872
68LIMK10.74757116
69CAMK1G0.73092395
70PINK10.72128129
71KSR10.71505039
72INSRR0.71125488
73ERBB30.69366394
74MST1R0.69356964
75FER0.69190608
76CDK11A0.69058282
77PRKCQ0.67899076
78WEE10.67488827
79CDK140.67426079
80CAMK2A0.65508048
81CAMK2B0.65203839
82ICK0.64341439
83CDK50.64260613
84YES10.64198590
85TRPM70.63667029
86KSR20.63343159
87CDK120.63219600
88BUB10.63067898
89ERBB20.62842978
90BLK0.58824472
91PRKG10.58794797
92CAMK2G0.57885525
93AKT20.57787856
94CDK70.57719060
95CAMK40.57609490
96BRAF0.56393898
97CDK190.56171626
98PKN20.55254507
99STK390.54917789
100MAP3K70.54240487
101SGK10.53519996
102MAPK150.53262784
103ABL20.52960377
104PRKACG0.52183740
105EPHB20.51066038
106MAPK110.50870142
107MUSK0.50364461
108CAMK2D0.50292190
109PRKACB0.49443931
110DYRK30.48425903
111MAPKAPK30.47812320
112PRKAA20.47653214
113PRKCB0.47526575
114TAOK20.46052746
115WNK40.45899289
116DMPK0.45412294
117PRKAA10.44663527
118CSNK1E0.44238896
119PRKCG0.42051014
120MAPK100.40644504
121STK110.40389717
122VRK20.40040171
123PRKACA0.39822347
124CHEK20.38558391
125NEK90.38043000
126ILK0.36605789
127CDC70.35087033
128MAPK70.29070884
129RPS6KB20.28335395
130MTOR0.21261523
131CDK10.19842430
132RPS6KA30.19497893
133AURKA0.18739552
134IRAK30.18517784
135ROCK10.18329237
136RPS6KA10.17349633
137CDK20.17170399
138PRKCI0.16797227
139MAP3K10.15765367
140RPS6KA60.15683676
141MAPK140.15527938
142GSK3B0.15364376
143PAK10.14854530
144PDPK10.14450127
145LRRK20.14304170
146CDK40.12804898
147MAPK90.12767087
148TESK10.12255427

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50125472
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.45675452
3Nitrogen metabolism_Homo sapiens_hsa009103.31194605
4Arginine biosynthesis_Homo sapiens_hsa002203.05813025
5Tryptophan metabolism_Homo sapiens_hsa003803.00725787
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61605125
7Butanoate metabolism_Homo sapiens_hsa006502.31398840
8Complement and coagulation cascades_Homo sapiens_hsa046102.31378627
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.31366231
10Phenylalanine metabolism_Homo sapiens_hsa003602.29821879
11Fatty acid degradation_Homo sapiens_hsa000712.25409252
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22367957
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21131470
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.11046623
15Tyrosine metabolism_Homo sapiens_hsa003502.10957403
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07593172
17Propanoate metabolism_Homo sapiens_hsa006401.92209672
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.87138462
19Histidine metabolism_Homo sapiens_hsa003401.86438445
20Fatty acid metabolism_Homo sapiens_hsa012121.76404696
21Peroxisome_Homo sapiens_hsa041461.75363485
22Fatty acid elongation_Homo sapiens_hsa000621.74849748
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.67262940
24Sulfur metabolism_Homo sapiens_hsa009201.58107260
25Parkinsons disease_Homo sapiens_hsa050121.55072779
26PPAR signaling pathway_Homo sapiens_hsa033201.54943682
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44430833
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.41494928
29beta-Alanine metabolism_Homo sapiens_hsa004101.40936627
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40721710
31Oxytocin signaling pathway_Homo sapiens_hsa049211.40083025
32Pentose phosphate pathway_Homo sapiens_hsa000301.39922780
33Calcium signaling pathway_Homo sapiens_hsa040201.39658537
34Retinol metabolism_Homo sapiens_hsa008301.38267803
35Oxidative phosphorylation_Homo sapiens_hsa001901.37621977
36Pyruvate metabolism_Homo sapiens_hsa006201.33885771
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30614522
38Starch and sucrose metabolism_Homo sapiens_hsa005001.24268664
39Bile secretion_Homo sapiens_hsa049761.22754767
40Fructose and mannose metabolism_Homo sapiens_hsa000511.22120262
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21682703
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.19224131
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18188680
44Chemical carcinogenesis_Homo sapiens_hsa052041.17228473
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16793428
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16673658
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.12881330
48Steroid biosynthesis_Homo sapiens_hsa001001.10533086
49Cocaine addiction_Homo sapiens_hsa050301.02090999
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.01985371
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01594733
52Biosynthesis of amino acids_Homo sapiens_hsa012301.00794673
53Alzheimers disease_Homo sapiens_hsa050100.99162244
54Staphylococcus aureus infection_Homo sapiens_hsa051500.99046350
55Carbon metabolism_Homo sapiens_hsa012000.98943889
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.93775741
57Fat digestion and absorption_Homo sapiens_hsa049750.92291845
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91399846
59ABC transporters_Homo sapiens_hsa020100.91114204
60Selenocompound metabolism_Homo sapiens_hsa004500.86537534
61Arginine and proline metabolism_Homo sapiens_hsa003300.85689611
62Vitamin B6 metabolism_Homo sapiens_hsa007500.84634466
63Bladder cancer_Homo sapiens_hsa052190.84420488
64Tight junction_Homo sapiens_hsa045300.80220944
65Cardiac muscle contraction_Homo sapiens_hsa042600.79564323
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.79346495
67Nicotine addiction_Homo sapiens_hsa050330.70419059
68Glioma_Homo sapiens_hsa052140.69845256
69Prion diseases_Homo sapiens_hsa050200.68758636
70Folate biosynthesis_Homo sapiens_hsa007900.68188365
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67276135
72Melanoma_Homo sapiens_hsa052180.66305499
73Caffeine metabolism_Homo sapiens_hsa002320.65330586
74Purine metabolism_Homo sapiens_hsa002300.64093933
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60967437
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.59183279
77Glucagon signaling pathway_Homo sapiens_hsa049220.58554024
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58119889
79Circadian entrainment_Homo sapiens_hsa047130.57189396
80Huntingtons disease_Homo sapiens_hsa050160.54886368
81Non-small cell lung cancer_Homo sapiens_hsa052230.53353740
82Galactose metabolism_Homo sapiens_hsa000520.51989098
83Synaptic vesicle cycle_Homo sapiens_hsa047210.51592011
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51580988
85Lysine degradation_Homo sapiens_hsa003100.49118378
86Gastric acid secretion_Homo sapiens_hsa049710.48809595
87MAPK signaling pathway_Homo sapiens_hsa040100.47882193
88GnRH signaling pathway_Homo sapiens_hsa049120.46830824
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46333491
90Long-term potentiation_Homo sapiens_hsa047200.44795540
91Metabolic pathways_Homo sapiens_hsa011000.44429200
92Focal adhesion_Homo sapiens_hsa045100.41572678
93Glycerolipid metabolism_Homo sapiens_hsa005610.41321952
94Renin secretion_Homo sapiens_hsa049240.41005049
95Insulin signaling pathway_Homo sapiens_hsa049100.40853541
96FoxO signaling pathway_Homo sapiens_hsa040680.40751406
97Amphetamine addiction_Homo sapiens_hsa050310.39949947
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.39550692
99cAMP signaling pathway_Homo sapiens_hsa040240.39044387
100Gap junction_Homo sapiens_hsa045400.39027635
101VEGF signaling pathway_Homo sapiens_hsa043700.38844698
102Sulfur relay system_Homo sapiens_hsa041220.37463797
103Vitamin digestion and absorption_Homo sapiens_hsa049770.37169696
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36955649
105Dopaminergic synapse_Homo sapiens_hsa047280.36087424
106Oocyte meiosis_Homo sapiens_hsa041140.35962293
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35853608
108Glutathione metabolism_Homo sapiens_hsa004800.35522952
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33640614
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33241402
111Serotonergic synapse_Homo sapiens_hsa047260.31773247
112Axon guidance_Homo sapiens_hsa043600.31598274
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30025977
114Pyrimidine metabolism_Homo sapiens_hsa002400.29971978
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29926141
116mTOR signaling pathway_Homo sapiens_hsa041500.29622531
117mRNA surveillance pathway_Homo sapiens_hsa030150.28738809
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27644803
119Insulin resistance_Homo sapiens_hsa049310.27007683
120Hippo signaling pathway_Homo sapiens_hsa043900.26923288
121Nucleotide excision repair_Homo sapiens_hsa034200.26757842
122Cell cycle_Homo sapiens_hsa041100.26716272
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.26158256
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.25825560
125Hedgehog signaling pathway_Homo sapiens_hsa043400.25595767
126RNA polymerase_Homo sapiens_hsa030200.25343453
127GABAergic synapse_Homo sapiens_hsa047270.25320967
128Regulation of autophagy_Homo sapiens_hsa041400.25183260
129Fatty acid biosynthesis_Homo sapiens_hsa000610.24548172
130AMPK signaling pathway_Homo sapiens_hsa041520.24199364
131Olfactory transduction_Homo sapiens_hsa047400.24082543
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23742708
133Basal cell carcinoma_Homo sapiens_hsa052170.23173081
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21890747
135Circadian rhythm_Homo sapiens_hsa047100.21729101
136Cholinergic synapse_Homo sapiens_hsa047250.17653362
137Long-term depression_Homo sapiens_hsa047300.17509179
138Ribosome_Homo sapiens_hsa030100.16016375
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14897866
140Melanogenesis_Homo sapiens_hsa049160.14830906
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14662251
142Dilated cardiomyopathy_Homo sapiens_hsa054140.14484791

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