PIWIL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis I (GO:0007141)7.84238191
2cilium or flagellum-dependent cell motility (GO:0001539)7.79569020
3chromosome organization involved in meiosis (GO:0070192)7.71619858
4meiotic nuclear division (GO:0007126)7.54848915
5fusion of sperm to egg plasma membrane (GO:0007342)6.93513663
6* regulation of meiosis I (GO:0060631)6.83464537
7meiosis I (GO:0007127)6.60608938
8* gene silencing by RNA (GO:0031047)5.97309502
9nuclear pore complex assembly (GO:0051292)5.91159947
10spermatid development (GO:0007286)5.85570880
11nuclear pore organization (GO:0006999)5.68513524
12axonemal dynein complex assembly (GO:0070286)5.46272326
13sperm motility (GO:0030317)5.40538830
14meiotic cell cycle process (GO:1903046)5.28603283
15sphingosine metabolic process (GO:0006670)5.28316863
16sperm-egg recognition (GO:0035036)5.25462923
17binding of sperm to zona pellucida (GO:0007339)5.20854402
18plasma membrane fusion (GO:0045026)5.04353037
19diol metabolic process (GO:0034311)4.90831534
20acrosome assembly (GO:0001675)4.90244117
21* DNA alkylation (GO:0006305)4.86991477
22* DNA methylation (GO:0006306)4.86991477
23sphingoid metabolic process (GO:0046519)4.86040198
24cell-cell recognition (GO:0009988)4.67265809
25pore complex assembly (GO:0046931)4.60970806
26behavioral response to nicotine (GO:0035095)4.57236834
27* germ cell development (GO:0007281)4.55260501
28negative regulation of meiosis (GO:0045835)4.51991211
29* meiotic cell cycle (GO:0051321)4.44674993
30sex differentiation (GO:0007548)4.44050787
31multicellular organism reproduction (GO:0032504)4.42292131
32epithelial cilium movement (GO:0003351)4.40563431
33motile cilium assembly (GO:0044458)4.39791009
34* gene silencing (GO:0016458)4.37453898
35synapsis (GO:0007129)4.19042435
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.17110092
37centriole replication (GO:0007099)4.17071211
38* spermatogenesis (GO:0007283)4.14797553
39* male gamete generation (GO:0048232)4.14249455
40regulation of histone H3-K9 methylation (GO:0051570)4.13133050
41sister chromatid cohesion (GO:0007062)4.10946787
42heterochromatin organization (GO:0070828)4.07438886
43reciprocal DNA recombination (GO:0035825)4.04018903
44reciprocal meiotic recombination (GO:0007131)4.04018903
45* cellular process involved in reproduction in multicellular organism (GO:0022412)4.02607910
46oocyte development (GO:0048599)4.00899332
47monoubiquitinated protein deubiquitination (GO:0035520)3.99612411
48meiotic chromosome segregation (GO:0045132)3.95554896
49positive regulation of male gonad development (GO:2000020)3.95362728
50acrosome reaction (GO:0007340)3.89027034
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.87219305
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.84459337
53* gamete generation (GO:0007276)3.82708886
54cilium movement (GO:0003341)3.80966183
55fertilization (GO:0009566)3.80683211
56DNA replication-dependent nucleosome assembly (GO:0006335)3.80071054
57DNA replication-dependent nucleosome organization (GO:0034723)3.80071054
58regulation of protein polyubiquitination (GO:1902914)3.75358384
59* DNA methylation or demethylation (GO:0044728)3.73898052
60negative regulation of DNA repair (GO:0045738)3.71122963
61negative regulation of DNA-dependent DNA replication (GO:2000104)3.66708931
62fucose catabolic process (GO:0019317)3.64946219
63L-fucose metabolic process (GO:0042354)3.64946219
64L-fucose catabolic process (GO:0042355)3.64946219
65mitotic chromosome condensation (GO:0007076)3.59108038
66microtubule depolymerization (GO:0007019)3.57465534
67seminiferous tubule development (GO:0072520)3.56205052
68regulation of centriole replication (GO:0046599)3.53507043
69protein-chromophore linkage (GO:0018298)3.53034268
70DNA synthesis involved in DNA repair (GO:0000731)3.52759378
71reproduction (GO:0000003)3.48960885
72mitotic sister chromatid cohesion (GO:0007064)3.48584630
73negative regulation of inclusion body assembly (GO:0090084)3.45247781
74serotonin receptor signaling pathway (GO:0007210)3.43693364
75genitalia morphogenesis (GO:0035112)3.37439852
76regulation of protein glycosylation (GO:0060049)3.37414441
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.36732362
78somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36732362
79chaperone-mediated protein complex assembly (GO:0051131)3.36722358
80translesion synthesis (GO:0019985)3.36218181
81* positive regulation of meiosis (GO:0045836)3.35125128
82regulation of posttranscriptional gene silencing (GO:0060147)3.35037741
83regulation of gene silencing by miRNA (GO:0060964)3.35037741
84regulation of gene silencing by RNA (GO:0060966)3.35037741
85attachment of spindle microtubules to kinetochore (GO:0008608)3.34174220
86regulation of cilium movement (GO:0003352)3.32664170
87somite rostral/caudal axis specification (GO:0032525)3.32254954
88regulation of RNA export from nucleus (GO:0046831)3.31450425
89sulfate transmembrane transport (GO:1902358)3.29736022
90regulation of male gonad development (GO:2000018)3.29115418
91regulation of rhodopsin mediated signaling pathway (GO:0022400)3.28644852
92DNA packaging (GO:0006323)3.26801142
93resolution of meiotic recombination intermediates (GO:0000712)3.26053137
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22970725
95sulfate transport (GO:0008272)3.22833737
96mitotic nuclear envelope disassembly (GO:0007077)3.22670912
97histone H3-K9 methylation (GO:0051567)3.22550341
98* oogenesis (GO:0048477)3.18664490
99histone exchange (GO:0043486)3.17355409
100* positive regulation of meiotic cell cycle (GO:0051446)3.13952662
101rhodopsin mediated signaling pathway (GO:0016056)3.13586577
102protein K6-linked ubiquitination (GO:0085020)3.12584417
103negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.12146293
104histone H2A acetylation (GO:0043968)3.10757458
105positive regulation of translational initiation (GO:0045948)3.07329717
106photoreceptor cell maintenance (GO:0045494)3.06438643
107nuclear envelope disassembly (GO:0051081)3.05445284
108membrane disassembly (GO:0030397)3.05445284
109single fertilization (GO:0007338)3.05052309
110chromosome organization (GO:0051276)3.00014195
111chromosome condensation (GO:0030261)2.99962247
112* DNA modification (GO:0006304)2.99862909
113nucleus organization (GO:0006997)2.99067189
114cell wall macromolecule metabolic process (GO:0044036)2.98579445
115cell wall macromolecule catabolic process (GO:0016998)2.98579445
116chromatin assembly (GO:0031497)2.98332434
117regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.98078006
118indolalkylamine metabolic process (GO:0006586)2.97856678
119protein polyglutamylation (GO:0018095)2.97341324
120glycerophospholipid catabolic process (GO:0046475)2.97329063
121regulation of chromosome segregation (GO:0051983)2.96074453
122* multicellular organismal reproductive process (GO:0048609)2.95901817
123sex determination (GO:0007530)2.91219729
124regulation of chromatin binding (GO:0035561)2.89463386
125retinal cone cell development (GO:0046549)2.88757907
126histone H4-K12 acetylation (GO:0043983)2.87487486
127paraxial mesoderm development (GO:0048339)2.86616174
128indole-containing compound catabolic process (GO:0042436)2.84471671
129indolalkylamine catabolic process (GO:0046218)2.84471671
130tryptophan catabolic process (GO:0006569)2.84471671
131negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.83973886
132male sex determination (GO:0030238)2.83946210
133gonadal mesoderm development (GO:0007506)2.83238355
134detection of light stimulus involved in sensory perception (GO:0050962)2.83137755
135detection of light stimulus involved in visual perception (GO:0050908)2.83137755
136centriole assembly (GO:0098534)2.82666264
137phosphatidylinositol acyl-chain remodeling (GO:0036149)2.82323541
138lipopolysaccharide biosynthetic process (GO:0009103)2.80796286
139behavioral response to ethanol (GO:0048149)2.80646528
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76722888
141RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76722888
142recombinational repair (GO:0000725)2.76709426
143double-strand break repair via homologous recombination (GO:0000724)2.75667163
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73260473
145reflex (GO:0060004)2.72378409
146platelet dense granule organization (GO:0060155)2.70528874
147aspartate family amino acid catabolic process (GO:0009068)2.70383437
148kidney morphogenesis (GO:0060993)2.68545067
149tyrosine metabolic process (GO:0006570)2.67782320
150aromatic amino acid family catabolic process (GO:0009074)2.66129429
151positive regulation of developmental pigmentation (GO:0048087)2.65690774
152DNA deamination (GO:0045006)2.65278467
153heme transport (GO:0015886)2.63456372
154regulation of mesoderm development (GO:2000380)2.58034276
155neural tube formation (GO:0001841)2.57408027
156auditory receptor cell stereocilium organization (GO:0060088)2.54689513
157sulfation (GO:0051923)2.53746525
158regulation of pigment cell differentiation (GO:0050932)2.51460561
159nodal signaling pathway (GO:0038092)2.51014382
160phosphatidylserine acyl-chain remodeling (GO:0036150)2.49243691
161nonmotile primary cilium assembly (GO:0035058)2.47566286
162negative regulation of telomere maintenance (GO:0032205)2.47291396
163response to pheromone (GO:0019236)2.46921976
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.45494406
165L-phenylalanine catabolic process (GO:0006559)2.45494406
166axoneme assembly (GO:0035082)2.44380163
167kynurenine metabolic process (GO:0070189)2.42907509
168phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.42674652
169cellular ketone body metabolic process (GO:0046950)2.41363067
170* piRNA metabolic process (GO:0034587)14.1293995
171male meiosis (GO:0007140)10.9368449
172synaptonemal complex assembly (GO:0007130)10.9097353
173synaptonemal complex organization (GO:0070193)10.7147592
174* DNA methylation involved in gamete generation (GO:0043046)10.0741246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19034296
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.08403921
3ZNF274_21170338_ChIP-Seq_K562_Hela3.79643337
4IGF1R_20145208_ChIP-Seq_DFB_Human3.56355454
5VDR_22108803_ChIP-Seq_LS180_Human3.10801595
6GBX2_23144817_ChIP-Seq_PC3_Human3.10729427
7EZH2_22144423_ChIP-Seq_EOC_Human3.03729531
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.93234483
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92685610
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.86264007
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81277803
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76136202
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59978146
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57000699
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35407257
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30063775
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29313087
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29313087
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29313087
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28680986
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28620072
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.28123211
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23246838
24AR_21909140_ChIP-Seq_LNCAP_Human2.15210204
25P300_19829295_ChIP-Seq_ESCs_Human2.10447128
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.07305092
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.02953609
28FUS_26573619_Chip-Seq_HEK293_Human2.00018514
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.4348272
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95517433
31EWS_26573619_Chip-Seq_HEK293_Human1.90627245
32GATA1_26923725_Chip-Seq_HPCs_Mouse1.90527462
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87713714
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.85844228
35ER_23166858_ChIP-Seq_MCF-7_Human1.85126833
36TAF15_26573619_Chip-Seq_HEK293_Human1.84869533
37UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77249445
38AR_21572438_ChIP-Seq_LNCaP_Human1.76526774
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72477334
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69131541
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68970811
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68519817
43STAT3_23295773_ChIP-Seq_U87_Human1.67610216
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66508189
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65849245
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65711751
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64286281
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.61026986
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60842611
50AR_25329375_ChIP-Seq_VCAP_Human1.60513200
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60249319
52* TCF4_23295773_ChIP-Seq_U87_Human1.59767022
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59718650
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57587905
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.57461949
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56096001
57KDM5A_27292631_Chip-Seq_BREAST_Human1.54843260
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52502731
59NANOG_19829295_ChIP-Seq_ESCs_Human1.51982834
60SOX2_19829295_ChIP-Seq_ESCs_Human1.51982834
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50128060
62CBP_20019798_ChIP-Seq_JUKART_Human1.50128060
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50107424
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.48655155
65* SMAD4_21799915_ChIP-Seq_A2780_Human1.47797649
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47464876
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46464821
68BCAT_22108803_ChIP-Seq_LS180_Human1.45134521
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44046314
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.44012883
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42502181
72TP53_22573176_ChIP-Seq_HFKS_Human1.42034006
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41917748
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.41191425
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.37856945
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37040122
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36239632
78FOXA1_25329375_ChIP-Seq_VCAP_Human1.35178746
79FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35178746
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.35076718
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34050186
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.33861711
83* HOXB7_26014856_ChIP-Seq_BT474_Human1.33452705
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30926129
85TCF4_22108803_ChIP-Seq_LS180_Human1.29533987
86XRN2_22483619_ChIP-Seq_HELA_Human1.29481168
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25745725
88RUNX2_22187159_ChIP-Seq_PCA_Human1.25532495
89STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24552811
90* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24479586
91* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24479586
92DCP1A_22483619_ChIP-Seq_HELA_Human1.24228588
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.23901561
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22359102
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.21912231
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21886843
97ELK4_26923725_Chip-Seq_MESODERM_Mouse1.21213562
98VDR_23849224_ChIP-Seq_CD4+_Human1.21191994
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19929635
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19911879
101CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17934018
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.17812012
103REST_21632747_ChIP-Seq_MESCs_Mouse1.17680824
104NCOR_22424771_ChIP-Seq_293T_Human1.17639262
105GABP_19822575_ChIP-Seq_HepG2_Human1.17481331
106FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15803223
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15615701
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14825017
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.14723218
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13692802
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13061049
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12941307
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12939291
114HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.12667002
115ZNF263_19887448_ChIP-Seq_K562_Human1.12293135
116FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11998571
117* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11636617
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.11623823
119TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11053793
120* CDX2_22108803_ChIP-Seq_LS180_Human1.10415131
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10016515
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09475643
123FOXH1_21741376_ChIP-Seq_EPCs_Human1.08745369
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08433205
125AR_20517297_ChIP-Seq_VCAP_Human1.07100826
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07025450
127NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04767523
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04044704
129NANOG_18555785_Chip-Seq_ESCs_Mouse1.03734780
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01768591
131EST1_17652178_ChIP-ChIP_JURKAT_Human1.01183678
132AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01136609
133TAL1_26923725_Chip-Seq_HPCs_Mouse1.00869624
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00818107
135SMAD3_21741376_ChIP-Seq_ESCs_Human1.00645762
136FOXP3_21729870_ChIP-Seq_TREG_Human1.00462636
137CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00109050
138MYC_18940864_ChIP-ChIP_HL60_Human0.99955954
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99769767
140CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98117113
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97584690
142TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97484492
143PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97053556
144* MYC_19829295_ChIP-Seq_ESCs_Human0.96823904
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96778786
146POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95276520
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.95218078
148RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95184412
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95054931
150YY1_21170310_ChIP-Seq_MESCs_Mouse0.94006637
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90890936
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90653067
153TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90202333
154KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89871066
155SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88109195
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87713600
157CIITA_25753668_ChIP-Seq_RAJI_Human0.87575418
158SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86651978
159TTF2_22483619_ChIP-Seq_HELA_Human0.86549901
160YY1_22570637_ChIP-Seq_MALME-3M_Human0.86302762
161TFEB_21752829_ChIP-Seq_HELA_Human0.85479969
162SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84604436
163TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83316122
164NANOG_21062744_ChIP-ChIP_HESCs_Human0.80805980
165FLI1_27457419_Chip-Seq_LIVER_Mouse0.80788087
166PHF8_20622854_ChIP-Seq_HELA_Human0.77579730
167EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75856576
168* OCT4_19829295_ChIP-Seq_ESCs_Human0.75387571
169NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.75368227
170RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72338801
171FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.72137823
172CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71822419
173TP53_22127205_ChIP-Seq_IMR90_Human0.71706087
174GABP_17652178_ChIP-ChIP_JURKAT_Human0.70109242
175ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69839241
176FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.69394147
177TP63_19390658_ChIP-ChIP_HaCaT_Human0.68611436
178* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68355059
179GATA3_21867929_ChIP-Seq_CD8_Mouse0.67179706
180RNF2_27304074_Chip-Seq_NSC_Mouse0.66965480
181PCGF2_27294783_Chip-Seq_ESCs_Mouse0.66241732
182PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.66125080
183GATA3_26560356_Chip-Seq_TH1_Human0.65814897
184DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65606536
185RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64638672
186MYB_26560356_Chip-Seq_TH1_Human0.64083904
187* WDR5_24793694_ChIP-Seq_LNCAP_Human0.63910138
188THAP11_20581084_ChIP-Seq_MESCs_Mouse0.63743645
189STAT1_17558387_ChIP-Seq_HELA_Human0.63670734
190TCF7_22412390_ChIP-Seq_EML_Mouse0.63316282
191BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.63290028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.70136679
2MP0005410_abnormal_fertilization6.19746441
3MP0002837_dystrophic_cardiac_calcinosis5.49622641
4MP0003136_yellow_coat_color4.80290227
5MP0008995_early_reproductive_senescence4.40070335
6* MP0001929_abnormal_gametogenesis4.25448341
7* MP0002210_abnormal_sex_determination4.19765283
8MP0008057_abnormal_DNA_replication4.00520742
9* MP0003698_abnormal_male_reproductive3.85512046
10MP0005171_absent_coat_pigmentation3.64257424
11* MP0001145_abnormal_male_reproductive3.46592031
12MP0003786_premature_aging3.32171689
13MP0010094_abnormal_chromosome_stability3.32104729
14* MP0000653_abnormal_sex_gland2.98716149
15MP0003111_abnormal_nucleus_morphology2.77814929
16MP0008058_abnormal_DNA_repair2.73451953
17MP0003878_abnormal_ear_physiology2.60756189
18MP0005377_hearing/vestibular/ear_phenot2.60756189
19MP0003693_abnormal_embryo_hatching2.34277506
20MP0004147_increased_porphyrin_level2.24821000
21MP0003195_calcinosis2.22464476
22MP0003077_abnormal_cell_cycle2.20474476
23* MP0002161_abnormal_fertility/fecundity2.19254630
24MP0004957_abnormal_blastocyst_morpholog2.07443366
25MP0008007_abnormal_cellular_replicative2.04468550
26MP0010307_abnormal_tumor_latency2.01067447
27MP0002653_abnormal_ependyma_morphology2.00067032
28MP0005551_abnormal_eye_electrophysiolog1.99062829
29MP0002138_abnormal_hepatobiliary_system1.90908397
30MP0001986_abnormal_taste_sensitivity1.83474785
31MP0006292_abnormal_olfactory_placode1.78098669
32MP0002938_white_spotting1.75593777
33MP0005623_abnormal_meninges_morphology1.71820406
34MP0002160_abnormal_reproductive_system1.69020212
35MP0001730_embryonic_growth_arrest1.68894776
36MP0002735_abnormal_chemical_nociception1.67402865
37MP0001486_abnormal_startle_reflex1.61179302
38MP0003123_paternal_imprinting1.60292461
39MP0005646_abnormal_pituitary_gland1.57597533
40MP0001984_abnormal_olfaction1.57161627
41MP0000372_irregular_coat_pigmentation1.53368576
42MP0001968_abnormal_touch/_nociception1.51502223
43MP0002272_abnormal_nervous_system1.47255020
44MP0006072_abnormal_retinal_apoptosis1.44624422
45MP0005174_abnormal_tail_pigmentation1.43176964
46MP0009745_abnormal_behavioral_response1.43163772
47MP0004885_abnormal_endolymph1.41302137
48MP0005076_abnormal_cell_differentiation1.41099790
49MP0001485_abnormal_pinna_reflex1.38602174
50MP0008872_abnormal_physiological_respon1.38489019
51MP0002638_abnormal_pupillary_reflex1.37137537
52MP0002876_abnormal_thyroid_physiology1.35970182
53MP0004043_abnormal_pH_regulation1.35314028
54MP0009278_abnormal_bone_marrow1.33981357
55MP0005085_abnormal_gallbladder_physiolo1.32540845
56MP0009046_muscle_twitch1.31142717
57MP0003646_muscle_fatigue1.29578381
58MP0001661_extended_life_span1.28765611
59MP0005075_abnormal_melanosome_morpholog1.28341081
60MP0001501_abnormal_sleep_pattern1.27809580
61MP0005253_abnormal_eye_physiology1.27101087
62MP0005647_abnormal_sex_gland1.22388104
63MP0000350_abnormal_cell_proliferation1.21217075
64MP0006276_abnormal_autonomic_nervous1.19602450
65MP0008932_abnormal_embryonic_tissue1.18097918
66MP0004808_abnormal_hematopoietic_stem1.18078422
67MP0002736_abnormal_nociception_after1.15100985
68MP0004142_abnormal_muscle_tone1.14518899
69MP0001119_abnormal_female_reproductive1.13779810
70MP0010352_gastrointestinal_tract_polyps1.10865549
71MP0001672_abnormal_embryogenesis/_devel1.08557169
72MP0005380_embryogenesis_phenotype1.08557169
73MP0004197_abnormal_fetal_growth/weight/1.07286460
74MP0002095_abnormal_skin_pigmentation1.05999861
75MP0002254_reproductive_system_inflammat1.04891943
76MP0001727_abnormal_embryo_implantation1.01684377
77MP0005389_reproductive_system_phenotype1.00676316
78MP0005645_abnormal_hypothalamus_physiol1.00351691
79MP0002084_abnormal_developmental_patter1.00149317
80MP0005365_abnormal_bile_salt0.98379410
81MP0001697_abnormal_embryo_size0.97690635
82MP0008875_abnormal_xenobiotic_pharmacok0.96415592
83MP0003984_embryonic_growth_retardation0.95347388
84MP0004145_abnormal_muscle_electrophysio0.94722590
85MP0003137_abnormal_impulse_conducting0.94629223
86MP0004381_abnormal_hair_follicle0.94549962
87MP0010386_abnormal_urinary_bladder0.93808455
88MP0002085_abnormal_embryonic_tissue0.93619430
89MP0003936_abnormal_reproductive_system0.92898176
90MP0002733_abnormal_thermal_nociception0.92833845
91MP0000631_abnormal_neuroendocrine_gland0.92520079
92MP0004742_abnormal_vestibular_system0.92411168
93MP0002572_abnormal_emotion/affect_behav0.92312261
94MP0002088_abnormal_embryonic_growth/wei0.91309381
95MP0000313_abnormal_cell_death0.90947382
96MP0000566_synostosis0.90757301
97MP0008789_abnormal_olfactory_epithelium0.89247715
98MP0000569_abnormal_digit_pigmentation0.89242780
99MP0003699_abnormal_female_reproductive0.89180370
100MP0004215_abnormal_myocardial_fiber0.87671601
101MP0001970_abnormal_pain_threshold0.86523197
102MP0005397_hematopoietic_system_phenotyp0.85805761
103MP0001545_abnormal_hematopoietic_system0.85805761
104MP0002080_prenatal_lethality0.85738328
105MP0002163_abnormal_gland_morphology0.84821961
106MP0002751_abnormal_autonomic_nervous0.84211894
107MP0002557_abnormal_social/conspecific_i0.83087599
108MP0002064_seizures0.82966183
109MP0002086_abnormal_extraembryonic_tissu0.82733734
110MP0003718_maternal_effect0.81598896
111MP0003121_genomic_imprinting0.81208359
112MP0002229_neurodegeneration0.79739087
113MP0005386_behavior/neurological_phenoty0.79379238
114MP0004924_abnormal_behavior0.79379238
115MP0001324_abnormal_eye_pigmentation0.79044910
116MP0003252_abnormal_bile_duct0.78628386
117MP0004233_abnormal_muscle_weight0.77988970
118MP0002928_abnormal_bile_duct0.77525587
119MP0005423_abnormal_somatic_nervous0.77457989
120MP0002067_abnormal_sensory_capabilities0.77335869
121MP0003635_abnormal_synaptic_transmissio0.77084738
122MP0006054_spinal_hemorrhage0.77040573
123MP0001963_abnormal_hearing_physiology0.75854953
124MP0002734_abnormal_mechanical_nocicepti0.75464239
125MP0003890_abnormal_embryonic-extraembry0.74057729
126MP0000026_abnormal_inner_ear0.72545840
127MP0005195_abnormal_posterior_eye0.71995748
128MP0001764_abnormal_homeostasis0.71090400
129MP0003880_abnormal_central_pattern0.69911211
130MP0000427_abnormal_hair_cycle0.69620982
131MP0003787_abnormal_imprinting0.68797942
132MP0009672_abnormal_birth_weight0.66930084
133MP0002019_abnormal_tumor_incidence0.66816790
134MP0003115_abnormal_respiratory_system0.66602547
135MP0003315_abnormal_perineum_morphology0.65331431
136MP0001915_intracranial_hemorrhage0.64753422
137MP0000358_abnormal_cell_content/0.63847084
138MP0008260_abnormal_autophagy0.63233364
139MP0009703_decreased_birth_body0.60846418
140MP0000537_abnormal_urethra_morphology0.58058189
141MP0001293_anophthalmia0.57783368
142MP0002282_abnormal_trachea_morphology0.55678715
143MP0003045_fibrosis0.54214327
144MP0002009_preneoplasia0.52777951
145MP0005621_abnormal_cell_physiology0.51780547
146MP0005670_abnormal_white_adipose0.50768598
147MP0000647_abnormal_sebaceous_gland0.50513568
148MP0004134_abnormal_chest_morphology0.50343213
149MP0003879_abnormal_hair_cell0.49734119
150MP0005384_cellular_phenotype0.47077189
151MP0002102_abnormal_ear_morphology0.47033045
152MP0005395_other_phenotype0.46612083
153MP0002092_abnormal_eye_morphology0.44050173
154MP0003861_abnormal_nervous_system0.41069728
155MP0003221_abnormal_cardiomyocyte_apopto0.41036431
156MP0003119_abnormal_digestive_system0.39869736
157MP0006138_congestive_heart_failure0.38860395
158MP0000428_abnormal_craniofacial_morphol0.37616746
159MP0003567_abnormal_fetal_cardiomyocyte0.35872537
160MP0002697_abnormal_eye_size0.34143166
161MP0000432_abnormal_head_morphology0.34103583
162MP0001919_abnormal_reproductive_system0.33132695
163MP0003705_abnormal_hypodermis_morpholog0.32424011
164MP0000733_abnormal_muscle_development0.31576200
165MP0000703_abnormal_thymus_morphology0.31292998
166MP0000383_abnormal_hair_follicle0.30346950
167MP0003448_altered_tumor_morphology0.30211491
168MP0003941_abnormal_skin_development0.29903069
169MP0005666_abnormal_adipose_tissue0.29845951
170MP0003937_abnormal_limbs/digits/tail_de0.29026206
171MP0004084_abnormal_cardiac_muscle0.28906112

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.52308302
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.42883339
3Absent/shortened dynein arms (HP:0200106)7.42883339
4Gonadotropin excess (HP:0000837)6.46961019
5Azoospermia (HP:0000027)5.80405594
6Abnormality of the lower motor neuron (HP:0002366)5.56138911
7Abnormal spermatogenesis (HP:0008669)5.55336321
8Abnormal respiratory motile cilium physiology (HP:0012261)5.51821884
9Abnormal respiratory epithelium morphology (HP:0012253)5.12741437
10Abnormal respiratory motile cilium morphology (HP:0005938)5.12741437
11Rhinitis (HP:0012384)5.11326520
1211 pairs of ribs (HP:0000878)4.90693581
13Infertility (HP:0000789)4.69399276
14Male infertility (HP:0003251)4.53189501
15Pancreatic cysts (HP:0001737)4.50875263
16Chronic bronchitis (HP:0004469)4.30008840
17Abnormal ciliary motility (HP:0012262)4.11505654
18Nasal polyposis (HP:0100582)4.10398909
19Focal motor seizures (HP:0011153)3.96770956
20Fibular hypoplasia (HP:0003038)3.77626189
21Amyotrophic lateral sclerosis (HP:0007354)3.61670166
22Impulsivity (HP:0100710)3.56593506
23Abnormality of the renal cortex (HP:0011035)3.52987229
24Upper motor neuron abnormality (HP:0002127)3.48858699
25Nephronophthisis (HP:0000090)3.46102266
26Amelogenesis imperfecta (HP:0000705)3.40005633
27Selective tooth agenesis (HP:0001592)3.38673309
28Pancreatic fibrosis (HP:0100732)3.38242680
29Abnormality of the anterior horn cell (HP:0006802)3.35463297
30Degeneration of anterior horn cells (HP:0002398)3.35463297
31Congenital stationary night blindness (HP:0007642)3.24840044
32Abnormality of the nasal mucosa (HP:0000433)3.23493978
33True hermaphroditism (HP:0010459)3.09428064
34Colon cancer (HP:0003003)3.05576927
35Bronchiectasis (HP:0002110)2.96737828
36Pendular nystagmus (HP:0012043)2.96119578
37Missing ribs (HP:0000921)2.94406474
38Type II lissencephaly (HP:0007260)2.91418575
39Hand muscle atrophy (HP:0009130)2.85924948
40Chromsome breakage (HP:0040012)2.85480022
41Bronchitis (HP:0012387)2.77356370
42Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77050669
43Progressive inability to walk (HP:0002505)2.76381138
44Inability to walk (HP:0002540)2.71836817
45Cystic liver disease (HP:0006706)2.70888965
46Hyperglycinuria (HP:0003108)2.59074844
47Gonadal dysgenesis (HP:0000133)2.55441871
48Abnormality of the labia minora (HP:0012880)2.53155620
49Male pseudohermaphroditism (HP:0000037)2.53127284
50Tubulointerstitial nephritis (HP:0001970)2.52877129
51Abnormality of the renal medulla (HP:0100957)2.52553730
52Hyperventilation (HP:0002883)2.45815720
53Abolished electroretinogram (ERG) (HP:0000550)2.45655334
54Attenuation of retinal blood vessels (HP:0007843)2.41998717
55Aplasia/Hypoplasia of the fibula (HP:0006492)2.40297411
56Ectopic kidney (HP:0000086)2.39033348
57Metaphyseal cupping (HP:0003021)2.37319937
58Tubular atrophy (HP:0000092)2.35700505
59Polydipsia (HP:0001959)2.35020880
60Abnormal drinking behavior (HP:0030082)2.35020880
61Heterotopia (HP:0002282)2.33265565
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.32919994
63Prominent nose (HP:0000448)2.31351679
64Decreased circulating renin level (HP:0003351)2.30203443
65Medial flaring of the eyebrow (HP:0010747)2.27622906
66Supernumerary spleens (HP:0009799)2.27216272
67Focal seizures (HP:0007359)2.25932531
68Hyperglycinemia (HP:0002154)2.24910902
69Gaze-evoked nystagmus (HP:0000640)2.24517407
70Abnormality of chromosome stability (HP:0003220)2.23810394
71Acanthocytosis (HP:0001927)2.23209301
72Renovascular hypertension (HP:0100817)2.22592451
73Dialeptic seizures (HP:0011146)2.20017278
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.18837375
75Ependymoma (HP:0002888)2.18534098
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17168775
77Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.16210947
78Recurrent otitis media (HP:0000403)2.12530824
79Parakeratosis (HP:0001036)2.11643203
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.11563088
81Congenital hepatic fibrosis (HP:0002612)2.10081243
82Cerebellar dysplasia (HP:0007033)2.09991368
83Optic nerve hypoplasia (HP:0000609)2.09752070
84Chronic hepatic failure (HP:0100626)2.08042413
85Stomach cancer (HP:0012126)2.07082911
86Lissencephaly (HP:0001339)2.06933316
87Upper limb amyotrophy (HP:0009129)2.06875712
88Distal upper limb amyotrophy (HP:0007149)2.06875712
89Abnormality of serine family amino acid metabolism (HP:0010894)2.06803001
90Abnormality of glycine metabolism (HP:0010895)2.06803001
91Intestinal atresia (HP:0011100)2.06757328
92Breast carcinoma (HP:0003002)2.03914495
93Volvulus (HP:0002580)2.03698195
94Impaired proprioception (HP:0010831)2.03570803
95Facial cleft (HP:0002006)2.03486725
96Agnosia (HP:0010524)2.03058039
97Abnormality of the renal collecting system (HP:0004742)2.00990091
98Anencephaly (HP:0002323)2.00733727
99Meckel diverticulum (HP:0002245)2.00569051
100Congenital sensorineural hearing impairment (HP:0008527)1.99428295
101Conjunctival telangiectasia (HP:0000524)1.98898310
102Aplasia/Hypoplasia of the uvula (HP:0010293)1.98851400
103Stage 5 chronic kidney disease (HP:0003774)1.97244003
104Short ribs (HP:0000773)1.96659975
105Sloping forehead (HP:0000340)1.96538779
106Astrocytoma (HP:0009592)1.96394774
107Abnormality of the astrocytes (HP:0100707)1.96394774
108Protruding tongue (HP:0010808)1.96127145
109Abnormality of the carotid arteries (HP:0005344)1.96110105
110Neoplasm of the adrenal cortex (HP:0100641)1.95242598
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.93770094
112Hypoplasia of the fovea (HP:0007750)1.93770094
113Retinitis pigmentosa (HP:0000510)1.93215379
114Abnormal rod and cone electroretinograms (HP:0008323)1.92442205
115Birth length less than 3rd percentile (HP:0003561)1.91384110
116Renal cortical cysts (HP:0000803)1.89107567
117Polyuria (HP:0000103)1.88831719
118Microglossia (HP:0000171)1.88282358
119Increased nuchal translucency (HP:0010880)1.87717324
120Tubulointerstitial fibrosis (HP:0005576)1.87555434
121Ulnar claw (HP:0001178)1.87414612
122Keratoconus (HP:0000563)1.87253451
123Increased corneal curvature (HP:0100692)1.87253451
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.87118742
125Papillary thyroid carcinoma (HP:0002895)1.86156440
126Duplicated collecting system (HP:0000081)1.86132145
127Tongue fasciculations (HP:0001308)1.85541069
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85030660
129Abnormality of alanine metabolism (HP:0010916)1.85030660
130Hyperalaninemia (HP:0003348)1.85030660
131Bony spicule pigmentary retinopathy (HP:0007737)1.84244140
132Small hand (HP:0200055)1.84094758
133Abnormality of the ileum (HP:0001549)1.83573392
134Severe visual impairment (HP:0001141)1.82718237
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82684795
136Abnormality of macular pigmentation (HP:0008002)1.82130028
137Oligodactyly (hands) (HP:0001180)1.81523428
138Retinal dysplasia (HP:0007973)1.80937293
139Abnormality of the preputium (HP:0100587)1.79317264
140Tubulointerstitial abnormality (HP:0001969)1.78956074
141Sclerocornea (HP:0000647)1.78412132
142Recurrent sinusitis (HP:0011108)1.77485649
143Hypothermia (HP:0002045)1.76306461
144Bile duct proliferation (HP:0001408)1.76207075
145Abnormal biliary tract physiology (HP:0012439)1.76207075
146Broad-based gait (HP:0002136)1.76012866
147Recurrent bronchitis (HP:0002837)1.75588057
148Glioma (HP:0009733)1.74939602
149Spinal muscular atrophy (HP:0007269)1.74259037
150Short tibia (HP:0005736)1.73380489
151Hypoplastic iliac wings (HP:0002866)1.73241626
152Dislocated radial head (HP:0003083)1.72191633
153Genital tract atresia (HP:0001827)1.71964247
154Premature ovarian failure (HP:0008209)1.71536796
155Absent thumb (HP:0009777)1.70870760
156Nephrogenic diabetes insipidus (HP:0009806)1.69578006
157Postaxial foot polydactyly (HP:0001830)1.69334051
158Duodenal stenosis (HP:0100867)1.68894174
159Small intestinal stenosis (HP:0012848)1.68894174
160Molar tooth sign on MRI (HP:0002419)1.68520405
161Abnormality of midbrain morphology (HP:0002418)1.68520405
162Sandal gap (HP:0001852)1.67466474
163Muscle fibrillation (HP:0010546)1.67219015
164Gait imbalance (HP:0002141)1.66932973
165Facial hemangioma (HP:0000329)1.66832022
166Median cleft lip (HP:0000161)1.66790389
167Secondary amenorrhea (HP:0000869)1.66728792
168Abnormality of the musculature of the hand (HP:0001421)1.65591426
169Nephroblastoma (Wilms tumor) (HP:0002667)1.65333033
170Truncal obesity (HP:0001956)1.64628062
171Congenital primary aphakia (HP:0007707)1.63876473
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.63846274
173Medulloblastoma (HP:0002885)1.63735381
174Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.62768895
175Increased CSF lactate (HP:0002490)1.62454031
176Vaginal atresia (HP:0000148)1.62177780
177Fair hair (HP:0002286)1.62126730
178Abnormality of the fovea (HP:0000493)1.61531099
179Large eyes (HP:0001090)1.61503614
180Acute encephalopathy (HP:0006846)1.61356835
181Abnormal sex determination (HP:0012244)1.61292263
182Sex reversal (HP:0012245)1.61292263
183Hyperacusis (HP:0010780)1.60731210
184Abnormality of male internal genitalia (HP:0000022)1.60585232
185Abnormality of the radial head (HP:0003995)1.60146737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.86316028
2PDK36.86316028
3FRK4.98331318
4CDK124.89928231
5PDK24.42423370
6BMPR1B3.50342535
7CDC73.48272980
8NEK23.07781494
9ICK3.00610664
10PRKD32.64988357
11WEE12.64315664
12PNCK2.53254063
13PINK12.39294970
14TESK12.07871300
15BRD42.05101708
16LATS21.98965857
17NUAK11.97951852
18ADRBK21.94232287
19ACVR1B1.79292990
20TTK1.76728934
21STK31.71810091
22CASK1.70173687
23CDK191.66813924
24NLK1.62718000
25ATR1.57246214
26PTK2B1.54060314
27BUB11.48516429
28TYRO31.45849927
29GRK11.44331521
30EIF2AK31.44294369
31TGFBR11.39847538
32PLK11.38410694
33OXSR11.35241966
34MAP4K21.34706482
35CHEK11.33131843
36PLK41.30098697
37CDK71.21010004
38TAOK31.19455007
39MTOR1.13629011
40TLK11.12460875
41WNK41.11830442
42CDK41.11321967
43TNIK1.10506479
44MST41.10275908
45CHEK21.07457011
46WNK11.06996147
47TAF11.05664999
48ATM1.04109243
49DAPK21.03716296
50MAPK131.02107374
51WNK31.02022732
52INSRR0.99718528
53PASK0.97018477
54TXK0.95960128
55STK38L0.95927722
56CDK90.94982573
57SRPK10.93791867
58ADRBK10.92852710
59FGFR20.91118926
60NME10.87463339
61PLK20.87427101
62CSNK1A1L0.86272284
63DYRK30.84638926
64EEF2K0.82590953
65CSNK1G10.78471294
66PHKG20.77038790
67PHKG10.77038790
68CSNK1G20.76588442
69PIK3CG0.76467277
70STK390.75251020
71TSSK60.74542856
72TRIM280.74450207
73MUSK0.74216665
74PRKCE0.73867711
75TIE10.71807695
76DYRK20.71568163
77CAMK1G0.70986585
78CDK20.69999570
79LATS10.69960742
80MKNK20.69651343
81STK160.68824277
82PRKAA20.68079865
83CAMK1D0.67768028
84STK380.66709099
85BRSK20.65521115
86AURKB0.64948708
87PAK30.63794673
88MAP3K40.62261037
89STK40.62046064
90EPHA20.59476030
91OBSCN0.58955438
92NTRK20.57499215
93CDK10.57277529
94VRK10.57005861
95CSNK1G30.56470782
96PLK30.55762428
97PRKCG0.55442790
98SCYL20.54467773
99EPHA40.48065018
100FER0.47858762
101EIF2AK10.47382523
102RIPK10.47048482
103BCR0.44501270
104CAMK2A0.42449080
105CCNB10.41303849
106PRKDC0.41154927
107MARK10.40242552
108MAP2K70.40242369
109CSNK1D0.39362365
110PAK40.39209443
111MARK30.38171431
112ZAK0.37921932
113PRKACA0.36727393
114PRKCI0.36579762
115MELK0.36454353
116MAP2K20.36339860
117PAK20.36156656
118PIM10.35557185
119GSK3B0.33801626
120RPS6KB10.33586115
121CSNK2A20.31683816
122PAK10.31581639
123DYRK1B0.31516229
124NEK10.31067680
125TRIB30.30985034
126MET0.30826888
127MKNK10.30822503
128CSNK1E0.30182278
129PDK10.29603001
130BCKDK0.29566078
131CDK60.29561674
132PRKG10.29349506
133GRK70.28999816
134RPS6KA40.28558969
135RPS6KB20.28341098
136AURKA0.28295258
137CSNK1A10.28201386
138PRKCQ0.27645698
139BMX0.27316872
140NEK90.27038819
141VRK20.26724713
142PRKAA10.26670507
143AKT30.25953494
144MAPK140.25926964
145PDGFRB0.25032192
146MAP3K100.24930497
147TEC0.24811793
148ALK0.24748189
149GRK50.24300764
150MAP3K70.24276055
151MAPK10.24181050
152PKN10.23866012
153MAPKAPK30.23785723
154CLK10.22847782
155MAP2K10.22641253
156MAPK80.21950450
157CHUK0.21915530
158RPS6KA10.20585789
159MAPK100.19825821
160EGFR0.19348066
161STK240.18901992
162PTK60.18380922
163CSNK2A10.18039886
164BRSK10.16686567
165AKT10.16256321
166DYRK1A0.16208656
167MAP3K80.15335624
168STK110.13875150

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.37701006
2Basal transcription factors_Homo sapiens_hsa030224.17621444
3Phototransduction_Homo sapiens_hsa047443.83469823
4RNA transport_Homo sapiens_hsa030133.76818197
5Fanconi anemia pathway_Homo sapiens_hsa034603.29447476
6Homologous recombination_Homo sapiens_hsa034403.05522482
7mRNA surveillance pathway_Homo sapiens_hsa030152.89820900
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.73883501
9Vitamin B6 metabolism_Homo sapiens_hsa007502.72955928
10Cell cycle_Homo sapiens_hsa041102.66031653
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.55230003
12Nicotine addiction_Homo sapiens_hsa050332.54684145
13DNA replication_Homo sapiens_hsa030302.52184743
14Spliceosome_Homo sapiens_hsa030402.40161303
15Mismatch repair_Homo sapiens_hsa034302.35472925
16Selenocompound metabolism_Homo sapiens_hsa004502.35214170
17Nucleotide excision repair_Homo sapiens_hsa034202.19141462
18RNA polymerase_Homo sapiens_hsa030202.18678198
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15705437
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041202.15229412
21Oocyte meiosis_Homo sapiens_hsa041142.11038156
22Butanoate metabolism_Homo sapiens_hsa006502.03524639
23Pentose phosphate pathway_Homo sapiens_hsa000301.95798377
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.93630161
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.86603990
26Nitrogen metabolism_Homo sapiens_hsa009101.82417423
27Base excision repair_Homo sapiens_hsa034101.78321819
28Antigen processing and presentation_Homo sapiens_hsa046121.76656445
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.75323043
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75050760
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72464209
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67416739
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67241615
34Proteasome_Homo sapiens_hsa030501.66638458
35Ether lipid metabolism_Homo sapiens_hsa005651.65481927
36Taste transduction_Homo sapiens_hsa047421.63362119
37RNA degradation_Homo sapiens_hsa030181.59890311
38Tryptophan metabolism_Homo sapiens_hsa003801.57348041
39One carbon pool by folate_Homo sapiens_hsa006701.45877096
40p53 signaling pathway_Homo sapiens_hsa041151.45681392
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44710920
42* Dorso-ventral axis formation_Homo sapiens_hsa043201.39376577
43ABC transporters_Homo sapiens_hsa020101.39053384
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38533972
45Non-homologous end-joining_Homo sapiens_hsa034501.36088894
46Pyrimidine metabolism_Homo sapiens_hsa002401.35458015
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.34326942
48Protein export_Homo sapiens_hsa030601.31404623
49Herpes simplex infection_Homo sapiens_hsa051681.28320913
50Fatty acid biosynthesis_Homo sapiens_hsa000611.28238010
51Epstein-Barr virus infection_Homo sapiens_hsa051691.28196211
52Morphine addiction_Homo sapiens_hsa050321.28119043
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28107841
54Caffeine metabolism_Homo sapiens_hsa002321.27725600
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26484459
56Pyruvate metabolism_Homo sapiens_hsa006201.25126476
57Sphingolipid metabolism_Homo sapiens_hsa006001.23779075
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.22317440
59Olfactory transduction_Homo sapiens_hsa047401.21457095
60Oxidative phosphorylation_Homo sapiens_hsa001901.18571780
61beta-Alanine metabolism_Homo sapiens_hsa004101.13858673
62Glycerolipid metabolism_Homo sapiens_hsa005611.12665959
63Lysine degradation_Homo sapiens_hsa003101.12357814
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09823757
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07798790
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07452221
67Viral carcinogenesis_Homo sapiens_hsa052031.04987348
68GABAergic synapse_Homo sapiens_hsa047271.04656694
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03864228
70Chemical carcinogenesis_Homo sapiens_hsa052041.03761817
71Purine metabolism_Homo sapiens_hsa002301.02422273
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02172236
73Arachidonic acid metabolism_Homo sapiens_hsa005900.97881252
74Influenza A_Homo sapiens_hsa051640.96033615
75Serotonergic synapse_Homo sapiens_hsa047260.95164595
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93952335
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.93636333
78Retinol metabolism_Homo sapiens_hsa008300.92852097
79Glucagon signaling pathway_Homo sapiens_hsa049220.92475063
80Legionellosis_Homo sapiens_hsa051340.90104855
81Calcium signaling pathway_Homo sapiens_hsa040200.87468618
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86452489
83HTLV-I infection_Homo sapiens_hsa051660.85176305
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.84739356
85Vitamin digestion and absorption_Homo sapiens_hsa049770.84718469
86Ovarian steroidogenesis_Homo sapiens_hsa049130.83856015
87Sulfur relay system_Homo sapiens_hsa041220.80948267
88Parkinsons disease_Homo sapiens_hsa050120.80792981
89Linoleic acid metabolism_Homo sapiens_hsa005910.78247899
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78239547
91Small cell lung cancer_Homo sapiens_hsa052220.75424256
92Peroxisome_Homo sapiens_hsa041460.74543328
93Insulin secretion_Homo sapiens_hsa049110.74309773
94Histidine metabolism_Homo sapiens_hsa003400.71900824
95Glutamatergic synapse_Homo sapiens_hsa047240.71755093
96Systemic lupus erythematosus_Homo sapiens_hsa053220.71710909
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71410457
98Biosynthesis of amino acids_Homo sapiens_hsa012300.71389244
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70800087
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.69537000
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.68435726
102TGF-beta signaling pathway_Homo sapiens_hsa043500.66042793
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65517425
104Collecting duct acid secretion_Homo sapiens_hsa049660.64703323
105Notch signaling pathway_Homo sapiens_hsa043300.63327174
106Metabolic pathways_Homo sapiens_hsa011000.61604236
107Fatty acid degradation_Homo sapiens_hsa000710.59001269
108Circadian rhythm_Homo sapiens_hsa047100.58860902
109Cardiac muscle contraction_Homo sapiens_hsa042600.58585058
110Salivary secretion_Homo sapiens_hsa049700.57777087
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57146607
112mTOR signaling pathway_Homo sapiens_hsa041500.56611554
113Circadian entrainment_Homo sapiens_hsa047130.55752038
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54577496
115Arginine and proline metabolism_Homo sapiens_hsa003300.54298427
116Folate biosynthesis_Homo sapiens_hsa007900.52894255
117Tyrosine metabolism_Homo sapiens_hsa003500.50977024
118Toxoplasmosis_Homo sapiens_hsa051450.49639413
119Inositol phosphate metabolism_Homo sapiens_hsa005620.47339326
120Mineral absorption_Homo sapiens_hsa049780.46692534
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45641224
122Hedgehog signaling pathway_Homo sapiens_hsa043400.45357051
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44814058
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44169016
125Carbon metabolism_Homo sapiens_hsa012000.43396461
126Steroid biosynthesis_Homo sapiens_hsa001000.42797925
127MicroRNAs in cancer_Homo sapiens_hsa052060.42787158
128N-Glycan biosynthesis_Homo sapiens_hsa005100.42401912
129Tight junction_Homo sapiens_hsa045300.42073141
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41974696
131Bile secretion_Homo sapiens_hsa049760.41383618
132Adherens junction_Homo sapiens_hsa045200.40001052
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39128579
134Huntingtons disease_Homo sapiens_hsa050160.39022559
135Prostate cancer_Homo sapiens_hsa052150.36817539
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36296259
137Alzheimers disease_Homo sapiens_hsa050100.35594162
138Basal cell carcinoma_Homo sapiens_hsa052170.33111971
139Hippo signaling pathway_Homo sapiens_hsa043900.33078548
140HIF-1 signaling pathway_Homo sapiens_hsa040660.32844882
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32755797
142AMPK signaling pathway_Homo sapiens_hsa041520.32412358
143Fat digestion and absorption_Homo sapiens_hsa049750.31709484
144Estrogen signaling pathway_Homo sapiens_hsa049150.31056103
145Propanoate metabolism_Homo sapiens_hsa006400.30110022
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29577984
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28860119
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28739558
149VEGF signaling pathway_Homo sapiens_hsa043700.27191347
150Measles_Homo sapiens_hsa051620.24969730
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24168114
152Amoebiasis_Homo sapiens_hsa051460.24080528
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23879218
154Protein digestion and absorption_Homo sapiens_hsa049740.23786665
155Viral myocarditis_Homo sapiens_hsa054160.23732520
156Salmonella infection_Homo sapiens_hsa051320.22603131
157ECM-receptor interaction_Homo sapiens_hsa045120.21371500
158Renin-angiotensin system_Homo sapiens_hsa046140.19854619
159Apoptosis_Homo sapiens_hsa042100.19775469
160Endocytosis_Homo sapiens_hsa041440.19425813
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.19338185
162Alcoholism_Homo sapiens_hsa050340.18688062
163Fructose and mannose metabolism_Homo sapiens_hsa000510.18551074
164Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18178817
165Pathways in cancer_Homo sapiens_hsa052000.18151618
166NF-kappa B signaling pathway_Homo sapiens_hsa040640.17255557
167Thyroid cancer_Homo sapiens_hsa052160.17047010
168Regulation of autophagy_Homo sapiens_hsa041400.16172312

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