PIWIL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)7.39120386
2multicellular organism reproduction (GO:0032504)6.85648499
3piRNA metabolic process (GO:0034587)6.46727427
4regulation of female gonad development (GO:2000194)6.04129732
5retinal cone cell development (GO:0046549)5.68954411
6DNA methylation involved in gamete generation (GO:0043046)5.28052507
7behavioral response to nicotine (GO:0035095)4.99791213
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69531104
9regulation of DNA methylation (GO:0044030)4.46208712
10protein K11-linked deubiquitination (GO:0035871)4.36338510
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.33930837
12reproduction (GO:0000003)4.31428486
13* meiotic cell cycle (GO:0051321)4.05939801
14oocyte development (GO:0048599)3.99017450
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.91185906
16regulation of meiosis I (GO:0060631)3.88905315
17L-fucose catabolic process (GO:0042355)3.69856588
18fucose catabolic process (GO:0019317)3.69856588
19L-fucose metabolic process (GO:0042354)3.69856588
20negative regulation of transcription regulatory region DNA binding (GO:2000678)3.67918651
21epithelial cilium movement (GO:0003351)3.67211178
22glycine transport (GO:0015816)3.66374522
23DNA deamination (GO:0045006)3.64394445
24positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.53900210
25regulation of calcium ion-dependent exocytosis (GO:0017158)3.51929615
26male meiosis I (GO:0007141)3.51702802
27female gamete generation (GO:0007292)3.49759803
28tachykinin receptor signaling pathway (GO:0007217)3.39634198
29protein polyglutamylation (GO:0018095)3.37111919
30response to pheromone (GO:0019236)3.36334517
31negative regulation of reproductive process (GO:2000242)3.33857712
32protein kinase C signaling (GO:0070528)3.32952987
33positive regulation of humoral immune response (GO:0002922)3.28846879
34detection of light stimulus involved in visual perception (GO:0050908)3.28190391
35detection of light stimulus involved in sensory perception (GO:0050962)3.28190391
36synaptic transmission, cholinergic (GO:0007271)3.24055490
37sperm-egg recognition (GO:0035036)3.22529647
38single fertilization (GO:0007338)3.19415749
39regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.18524910
40cilium movement (GO:0003341)3.13933573
41cilium or flagellum-dependent cell motility (GO:0001539)3.13584640
42gamma-aminobutyric acid transport (GO:0015812)3.12273187
43attachment of spindle microtubules to kinetochore (GO:0008608)3.07976103
44synapsis (GO:0007129)3.06754831
45regulation of steroid hormone secretion (GO:2000831)3.04813836
46fertilization (GO:0009566)3.03175516
47pyrimidine nucleobase catabolic process (GO:0006208)3.02369452
48behavioral response to ethanol (GO:0048149)2.97521244
49DNA methylation (GO:0006306)2.97377715
50DNA alkylation (GO:0006305)2.97377715
51regulation of histone H3-K9 methylation (GO:0051570)2.96594083
52positive regulation of histone H3-K4 methylation (GO:0051571)2.92965336
53* gene silencing by RNA (GO:0031047)2.92559276
54indolalkylamine metabolic process (GO:0006586)2.87450261
55photoreceptor cell development (GO:0042461)2.85895094
56centriole replication (GO:0007099)2.83954425
57regulation of glucokinase activity (GO:0033131)2.81494828
58regulation of hexokinase activity (GO:1903299)2.81494828
59male meiosis (GO:0007140)2.81220162
60positive regulation of gastrulation (GO:2000543)2.79978578
61protein K6-linked ubiquitination (GO:0085020)2.79607405
62nucleobase catabolic process (GO:0046113)2.75409693
63indole-containing compound catabolic process (GO:0042436)2.74762871
64indolalkylamine catabolic process (GO:0046218)2.74762871
65tryptophan catabolic process (GO:0006569)2.74762871
66DNA modification (GO:0006304)2.73885811
67kynurenine metabolic process (GO:0070189)2.72821601
68neuron fate determination (GO:0048664)2.69948769
69eye photoreceptor cell development (GO:0042462)2.69831898
70positive regulation of meiosis (GO:0045836)2.67939460
71positive regulation of uterine smooth muscle contraction (GO:0070474)2.67519954
72meiosis I (GO:0007127)2.67196251
73DNA methylation or demethylation (GO:0044728)2.67136546
74somite rostral/caudal axis specification (GO:0032525)2.66979908
75startle response (GO:0001964)2.63898768
76cellular ketone body metabolic process (GO:0046950)2.63390104
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63229904
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.63229904
79regulation of translation, ncRNA-mediated (GO:0045974)2.63229904
80cell-cell recognition (GO:0009988)2.63190339
81photoreceptor cell maintenance (GO:0045494)2.63065120
82base-excision repair, AP site formation (GO:0006285)2.61948058
83neural tube formation (GO:0001841)2.60799572
84regulation of action potential (GO:0098900)2.60593004
85binding of sperm to zona pellucida (GO:0007339)2.59434857
86ketone body metabolic process (GO:1902224)2.58739728
87protein localization to cilium (GO:0061512)2.58150303
88positive regulation of meiotic cell cycle (GO:0051446)2.58124963
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57872986
90head development (GO:0060322)2.57557472
91postsynaptic membrane organization (GO:0001941)2.56204178
92regulation of cell maturation (GO:1903429)2.55922221
93cilium morphogenesis (GO:0060271)2.53067514
94positive regulation of reproductive process (GO:2000243)2.49960329
95axoneme assembly (GO:0035082)2.47557485
96detection of mechanical stimulus involved in sensory perception (GO:0050974)2.47463572
97adaptation of signaling pathway (GO:0023058)2.44587902
98regulation of cilium movement (GO:0003352)2.43837353
99cAMP catabolic process (GO:0006198)2.42296711
100positive regulation of defense response to virus by host (GO:0002230)2.42216305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.43848060
2ZNF274_21170338_ChIP-Seq_K562_Hela3.49104786
3GBX2_23144817_ChIP-Seq_PC3_Human3.32237821
4VDR_22108803_ChIP-Seq_LS180_Human2.61850380
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49018696
6IGF1R_20145208_ChIP-Seq_DFB_Human2.16757808
7TAF15_26573619_Chip-Seq_HEK293_Human2.07633081
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06354377
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05526311
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05155092
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94011313
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93162496
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92102015
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90624634
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89082112
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84150735
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.81317202
18EWS_26573619_Chip-Seq_HEK293_Human1.79816858
19P300_19829295_ChIP-Seq_ESCs_Human1.78004944
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.75932066
21IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.73226836
22CBP_20019798_ChIP-Seq_JUKART_Human1.73226836
23FUS_26573619_Chip-Seq_HEK293_Human1.72551457
24ER_23166858_ChIP-Seq_MCF-7_Human1.70566971
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.69620063
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69594740
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69524437
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69189563
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66191848
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66038316
31* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63639681
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59132943
33AR_25329375_ChIP-Seq_VCAP_Human1.54619105
34SMAD4_21799915_ChIP-Seq_A2780_Human1.52661803
35TCF4_23295773_ChIP-Seq_U87_Human1.51833543
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51351824
37STAT3_23295773_ChIP-Seq_U87_Human1.51052169
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41646525
39REST_21632747_ChIP-Seq_MESCs_Mouse1.40408429
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39212742
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35930955
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34506217
43TP53_22573176_ChIP-Seq_HFKS_Human1.34492208
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32442603
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32442603
46BCAT_22108803_ChIP-Seq_LS180_Human1.31977230
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31464078
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31387063
49RUNX2_22187159_ChIP-Seq_PCA_Human1.30238550
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29903820
51RNF2_27304074_Chip-Seq_NSC_Mouse1.27623006
52PRDM14_20953172_ChIP-Seq_ESCs_Human1.26386447
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25503520
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.24894224
55MYC_18940864_ChIP-ChIP_HL60_Human1.23560810
56NCOR_22424771_ChIP-Seq_293T_Human1.22190711
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21638589
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.18800700
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18629261
60IRF1_19129219_ChIP-ChIP_H3396_Human1.18022030
61TCF4_22108803_ChIP-Seq_LS180_Human1.17823975
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.15233228
63NANOG_19829295_ChIP-Seq_ESCs_Human1.14887975
64SOX2_19829295_ChIP-Seq_ESCs_Human1.14887975
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14489212
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.14489212
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14356729
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14317791
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14168554
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.12601973
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.10602395
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09725598
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08104742
74NANOG_20526341_ChIP-Seq_ESCs_Human1.07024438
75AR_20517297_ChIP-Seq_VCAP_Human1.06956799
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06671685
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06436814
78AUTS2_25519132_ChIP-Seq_293T-REX_Human1.06241837
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05919807
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05827275
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04913316
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.02522091
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.02266388
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01468270
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.01279649
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01228984
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.00897469
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00197393
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.00134865
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.98727226
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97294243
92TAL1_26923725_Chip-Seq_HPCs_Mouse0.96986541
93EST1_17652178_ChIP-ChIP_JURKAT_Human0.96547960
94MYC_19829295_ChIP-Seq_ESCs_Human0.94908116
95CRX_20693478_ChIP-Seq_RETINA_Mouse0.93151120
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92061915
97HOXB7_26014856_ChIP-Seq_BT474_Human0.91892069
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91193317
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90296428
100CDX2_22108803_ChIP-Seq_LS180_Human0.90011870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.50546794
2MP0008877_abnormal_DNA_methylation4.00486224
3MP0006292_abnormal_olfactory_placode3.28397467
4MP0003195_calcinosis2.72021449
5MP0002138_abnormal_hepatobiliary_system2.68601434
6MP0002234_abnormal_pharynx_morphology2.60628090
7MP0008789_abnormal_olfactory_epithelium2.29802507
8MP0005551_abnormal_eye_electrophysiolog2.17559352
9MP0001986_abnormal_taste_sensitivity2.12727689
10MP0002102_abnormal_ear_morphology2.12631527
11MP0003879_abnormal_hair_cell2.07718128
12MP0006276_abnormal_autonomic_nervous2.03047810
13MP0005499_abnormal_olfactory_system1.99152455
14MP0005394_taste/olfaction_phenotype1.99152455
15MP0002272_abnormal_nervous_system1.90852848
16MP0001968_abnormal_touch/_nociception1.89272407
17MP0000569_abnormal_digit_pigmentation1.84208592
18MP0005395_other_phenotype1.82126992
19MP0003890_abnormal_embryonic-extraembry1.76440812
20MP0004142_abnormal_muscle_tone1.76065317
21MP0003880_abnormal_central_pattern1.75734812
22MP0003646_muscle_fatigue1.75484016
23MP0005646_abnormal_pituitary_gland1.68976878
24MP0000631_abnormal_neuroendocrine_gland1.68023273
25MP0002736_abnormal_nociception_after1.67862161
26MP0006072_abnormal_retinal_apoptosis1.66798760
27MP0003136_yellow_coat_color1.65909434
28MP0002638_abnormal_pupillary_reflex1.64000583
29MP0009745_abnormal_behavioral_response1.61771114
30MP0009046_muscle_twitch1.60896790
31MP0003787_abnormal_imprinting1.56820620
32MP0001929_abnormal_gametogenesis1.56745018
33MP0000427_abnormal_hair_cycle1.56208389
34MP0008058_abnormal_DNA_repair1.52381991
35MP0008875_abnormal_xenobiotic_pharmacok1.51712156
36MP0004147_increased_porphyrin_level1.44851527
37MP0001984_abnormal_olfaction1.44812902
38MP0005410_abnormal_fertilization1.43901514
39MP0002210_abnormal_sex_determination1.43049874
40MP0004043_abnormal_pH_regulation1.42696722
41MP0005253_abnormal_eye_physiology1.41113866
42MP0002876_abnormal_thyroid_physiology1.40484156
43MP0005075_abnormal_melanosome_morpholog1.40417396
44MP0005389_reproductive_system_phenotype1.38031341
45MP0000015_abnormal_ear_pigmentation1.37094811
46MP0003121_genomic_imprinting1.35742826
47MP0002735_abnormal_chemical_nociception1.34546043
48MP0002139_abnormal_hepatobiliary_system1.34292799
49MP0004885_abnormal_endolymph1.33197407
50MP0001486_abnormal_startle_reflex1.30571726
51MP0000372_irregular_coat_pigmentation1.29319466
52MP0005645_abnormal_hypothalamus_physiol1.28913455
53MP0003252_abnormal_bile_duct1.28700843
54MP0003699_abnormal_female_reproductive1.25674612
55MP0008995_early_reproductive_senescence1.22480414
56MP0000778_abnormal_nervous_system1.20503733
57MP0002160_abnormal_reproductive_system1.20388910
58MP0000653_abnormal_sex_gland1.19226492
59MP0001501_abnormal_sleep_pattern1.18432163
60MP0002095_abnormal_skin_pigmentation1.17718722
61MP0001324_abnormal_eye_pigmentation1.15895542
62MP0001919_abnormal_reproductive_system1.15259950
63MP0003698_abnormal_male_reproductive1.14335831
64MP0002928_abnormal_bile_duct1.11252147
65MP0005174_abnormal_tail_pigmentation1.09986376
66MP0001119_abnormal_female_reproductive1.09932794
67MP0004133_heterotaxia1.09473702
68MP0003635_abnormal_synaptic_transmissio1.09156795
69MP0008872_abnormal_physiological_respon1.08156063
70MP0005386_behavior/neurological_phenoty1.05825895
71MP0004924_abnormal_behavior1.05825895
72MP0002557_abnormal_social/conspecific_i1.04872322
73MP0002572_abnormal_emotion/affect_behav1.03968323
74MP0002751_abnormal_autonomic_nervous1.00414203
75MP0002163_abnormal_gland_morphology0.99719413
76MP0002064_seizures0.99525041
77MP0002161_abnormal_fertility/fecundity0.98989980
78MP0001905_abnormal_dopamine_level0.98753453
79MP0000383_abnormal_hair_follicle0.98465164
80MP0002653_abnormal_ependyma_morphology0.98115134
81MP0001502_abnormal_circadian_rhythm0.96656034
82MP0005360_urolithiasis0.96516160
83MP0005085_abnormal_gallbladder_physiolo0.94764319
84MP0002229_neurodegeneration0.93841900
85MP0001963_abnormal_hearing_physiology0.92485745
86MP0004742_abnormal_vestibular_system0.92307459
87MP0002063_abnormal_learning/memory/cond0.91403615
88MP0005195_abnormal_posterior_eye0.90459792
89MP0001293_anophthalmia0.90315577
90MP0001485_abnormal_pinna_reflex0.90072690
91MP0002067_abnormal_sensory_capabilities0.89847326
92MP0001529_abnormal_vocalization0.89308904
93MP0000049_abnormal_middle_ear0.88826085
94MP0002752_abnormal_somatic_nervous0.88586116
95MP0001145_abnormal_male_reproductive0.86587095
96MP0000647_abnormal_sebaceous_gland0.86134860
97MP0003693_abnormal_embryo_hatching0.83552397
98MP0004145_abnormal_muscle_electrophysio0.79754828
99MP0003119_abnormal_digestive_system0.77860691
100MP0000026_abnormal_inner_ear0.76780067

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.29747994
2Abnormality of midbrain morphology (HP:0002418)3.89921108
3Molar tooth sign on MRI (HP:0002419)3.89921108
4Pancreatic fibrosis (HP:0100732)3.72009367
5True hermaphroditism (HP:0010459)3.48770939
6Hypoplasia of the fovea (HP:0007750)3.42566216
7Aplasia/Hypoplasia of the fovea (HP:0008060)3.42566216
8Supernumerary spleens (HP:0009799)3.35036220
9Congenital stationary night blindness (HP:0007642)3.21852071
10Bile duct proliferation (HP:0001408)3.20411467
11Abnormal biliary tract physiology (HP:0012439)3.20411467
12Nephronophthisis (HP:0000090)3.14494512
13Abnormality of the fovea (HP:0000493)3.01940097
14Type II lissencephaly (HP:0007260)2.87101701
15Chronic hepatic failure (HP:0100626)2.80057001
16Attenuation of retinal blood vessels (HP:0007843)2.80025921
17Hyperventilation (HP:0002883)2.76340838
18Congenital sensorineural hearing impairment (HP:0008527)2.74280578
19Pendular nystagmus (HP:0012043)2.73263066
20Abnormality of the renal medulla (HP:0100957)2.72088379
21Abnormality of the renal cortex (HP:0011035)2.61271707
22Gaze-evoked nystagmus (HP:0000640)2.61194179
23Cystic liver disease (HP:0006706)2.60535936
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.55786885
25Anterior segment dysgenesis (HP:0007700)2.54599097
26Abolished electroretinogram (ERG) (HP:0000550)2.54307432
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.54196856
28Oligodactyly (hands) (HP:0001180)2.53598997
29Abnormality of the labia minora (HP:0012880)2.48380026
30Bony spicule pigmentary retinopathy (HP:0007737)2.44770290
31Abnormal ciliary motility (HP:0012262)2.37965045
32Focal motor seizures (HP:0011153)2.34851849
33Lissencephaly (HP:0001339)2.34452362
34Abnormal drinking behavior (HP:0030082)2.33011198
35Polydipsia (HP:0001959)2.33011198
36Decreased circulating renin level (HP:0003351)2.31148365
37Hypophosphatemic rickets (HP:0004912)2.28860050
38Aplasia/Hypoplasia of the tibia (HP:0005772)2.28382437
39Fair hair (HP:0002286)2.27596810
40Absent/shortened dynein arms (HP:0200106)2.26966463
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.26966463
42Pachygyria (HP:0001302)2.25271894
43Abnormal rod and cone electroretinograms (HP:0008323)2.23207572
44Medial flaring of the eyebrow (HP:0010747)2.22693253
45Abnormal respiratory motile cilium physiology (HP:0012261)2.21999543
46Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21927128
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.21253472
48Anencephaly (HP:0002323)2.20649694
49Septo-optic dysplasia (HP:0100842)2.20421108
50Infertility (HP:0000789)2.20174396
51Optic nerve hypoplasia (HP:0000609)2.19718905
52Aplasia/Hypoplasia of the macula (HP:0008059)2.17978391
53Abnormal respiratory motile cilium morphology (HP:0005938)2.14404360
54Abnormal respiratory epithelium morphology (HP:0012253)2.14404360
55Impulsivity (HP:0100710)2.13833547
56Abnormality of the ileum (HP:0001549)2.13549155
57Azoospermia (HP:0000027)2.12898086
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12298044
59Tubular atrophy (HP:0000092)2.07327912
60Sclerocornea (HP:0000647)2.05459135
61Acute necrotizing encephalopathy (HP:0006965)2.04781441
62Polyuria (HP:0000103)2.04619089
63Meckel diverticulum (HP:0002245)2.03662466
64Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.03343838
65Decreased central vision (HP:0007663)2.03266808
66Progressive inability to walk (HP:0002505)2.01662159
67Renal cortical cysts (HP:0000803)2.01422761
68Aplasia/Hypoplasia affecting the retina (HP:0008061)2.01205663
69Broad-based gait (HP:0002136)2.01185409
70Congenital hepatic fibrosis (HP:0002612)1.97058041
71Abnormality of abdominal situs (HP:0011620)1.95285911
72Abdominal situs inversus (HP:0003363)1.95285911
73Short tibia (HP:0005736)1.93856676
74Inability to walk (HP:0002540)1.90981828
75Focal seizures (HP:0007359)1.90839226
76Occipital encephalocele (HP:0002085)1.90275961
77Gonadotropin excess (HP:0000837)1.90085943
78Absent septum pellucidum (HP:0001331)1.88103844
79Methylmalonic acidemia (HP:0002912)1.87782842
803-Methylglutaconic aciduria (HP:0003535)1.85342648
81Dandy-Walker malformation (HP:0001305)1.84609540
82Concave nail (HP:0001598)1.82543509
83Gait imbalance (HP:0002141)1.81613403
84Increased circulating renin level (HP:0000848)1.81024176
85Acute encephalopathy (HP:0006846)1.80742046
86Progressive cerebellar ataxia (HP:0002073)1.80681214
87Postaxial foot polydactyly (HP:0001830)1.80486619
88Genetic anticipation (HP:0003743)1.80078716
89Preaxial hand polydactyly (HP:0001177)1.79897570
90Intestinal atresia (HP:0011100)1.79400394
91Osteomalacia (HP:0002749)1.78875723
92Progressive macrocephaly (HP:0004481)1.78753831
93Nephrogenic diabetes insipidus (HP:0009806)1.78451491
94Generalized hypopigmentation of hair (HP:0011358)1.77918149
95Abnormality of macular pigmentation (HP:0008002)1.77598244
96Cerebellar dysplasia (HP:0007033)1.77574672
97Patellar aplasia (HP:0006443)1.75991104
98Retinal dysplasia (HP:0007973)1.74924183
99Male pseudohermaphroditism (HP:0000037)1.73091942
100Median cleft lip (HP:0000161)1.72302289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.49882114
2WNK33.08256574
3PINK12.93187980
4MAPK132.55844383
5CDK192.54325973
6TRIM282.48320071
7MAP3K42.36986479
8ADRBK22.31114105
9BMPR1B2.25034580
10MAP4K22.17541988
11TAOK32.10885775
12OXSR12.05093862
13CASK2.01506986
14ZAK1.99475626
15NUAK11.89619907
16ACVR1B1.86760265
17GRK11.66154910
18MAP2K71.57094095
19TXK1.56970416
20NTRK31.51234141
21MARK11.43906439
22NTRK21.41838823
23INSRR1.40784872
24WNK41.29998299
25MAPKAPK31.29126289
26STK391.23708159
27CAMK1D1.22356068
28NEK61.16589998
29CAMKK21.14153155
30MAP3K91.13946204
31BCR1.10431182
32MUSK1.04308088
33CSNK1G31.02812187
34CSNK1G21.01299000
35CSNK1G11.00398048
36PRKCI0.99706345
37DYRK20.97708161
38TLK10.93092027
39PRKCG0.88655943
40DYRK1B0.88491356
41EPHB20.88372009
42CSNK1A1L0.85692879
43MAP3K130.82946591
44SIK20.82449629
45TIE10.82040517
46PLK10.78214699
47NEK20.77683837
48AURKA0.74694486
49CAMK10.74355797
50PRKCZ0.73585061
51TNK20.72751564
52CAMK1G0.71974849
53SIK30.71658754
54ADRBK10.69214499
55EPHA40.66608362
56PRKCE0.65927234
57TNIK0.65636223
58PLK20.65603845
59MAPKAPK50.63505734
60BUB10.62172559
61MARK30.61633639
62PLK30.61522307
63ARAF0.60306418
64CAMK40.59651583
65PAK30.58862454
66MKNK20.58084780
67STK30.57980540
68PRKAA10.57201684
69CAMK2A0.56983434
70CHUK0.56864168
71PRKACA0.56332920
72DYRK1A0.55974803
73PRKCQ0.55524378
74NME10.54918205
75PRKG10.54093437
76CSNK1D0.53591313
77VRK10.52263608
78TGFBR10.51957872
79PKN10.51900742
80TEC0.50854522
81NEK10.50296748
82CHEK20.49428194
83BCKDK0.49402329
84MINK10.48827490
85ATR0.48502475
86PRKAA20.47084779
87DAPK20.45538764
88PHKG10.45437823
89PHKG20.45437823
90ATM0.43324978
91MST40.41262026
92FER0.40908679
93EIF2AK30.40086212
94IKBKB0.39581737
95WEE10.39021087
96CDK50.37519720
97CSNK1A10.36339158
98MAP2K40.35967575
99CDK90.35775625
100STK110.35745645

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.16387654
2Phototransduction_Homo sapiens_hsa047442.88900386
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.86244768
4Caffeine metabolism_Homo sapiens_hsa002322.72017893
5Nicotine addiction_Homo sapiens_hsa050332.60540212
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49074761
7Linoleic acid metabolism_Homo sapiens_hsa005912.31392562
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.31287680
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19859345
10RNA polymerase_Homo sapiens_hsa030202.15169935
11Fanconi anemia pathway_Homo sapiens_hsa034602.11425761
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.07967557
13Ovarian steroidogenesis_Homo sapiens_hsa049132.03398694
14Homologous recombination_Homo sapiens_hsa034402.02978119
15Butanoate metabolism_Homo sapiens_hsa006502.02655325
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96572095
17Selenocompound metabolism_Homo sapiens_hsa004501.86593906
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.83107651
19Oxidative phosphorylation_Homo sapiens_hsa001901.73480076
20Olfactory transduction_Homo sapiens_hsa047401.72710710
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68862880
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.63838178
23Nitrogen metabolism_Homo sapiens_hsa009101.62549778
24RNA degradation_Homo sapiens_hsa030181.54932177
25Morphine addiction_Homo sapiens_hsa050321.53100829
26ABC transporters_Homo sapiens_hsa020101.46543451
27Tryptophan metabolism_Homo sapiens_hsa003801.45236828
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40220529
29Protein export_Homo sapiens_hsa030601.34764968
30Ether lipid metabolism_Homo sapiens_hsa005651.33433315
31Parkinsons disease_Homo sapiens_hsa050121.31403500
32Taste transduction_Homo sapiens_hsa047421.28633233
33Collecting duct acid secretion_Homo sapiens_hsa049661.24034215
34Huntingtons disease_Homo sapiens_hsa050161.22589178
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15680233
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.15159046
37GABAergic synapse_Homo sapiens_hsa047271.13432468
38Propanoate metabolism_Homo sapiens_hsa006401.09380578
39Peroxisome_Homo sapiens_hsa041461.07040686
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06511375
41Regulation of autophagy_Homo sapiens_hsa041401.06331216
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.00695428
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98808225
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97586095
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93275785
46Circadian entrainment_Homo sapiens_hsa047130.91076732
47Chemical carcinogenesis_Homo sapiens_hsa052040.90750682
48Serotonergic synapse_Homo sapiens_hsa047260.89423171
49RNA transport_Homo sapiens_hsa030130.85322500
50Retinol metabolism_Homo sapiens_hsa008300.84116561
51Oocyte meiosis_Homo sapiens_hsa041140.80240597
52Fatty acid elongation_Homo sapiens_hsa000620.79978061
53Glycerolipid metabolism_Homo sapiens_hsa005610.79274885
54Synaptic vesicle cycle_Homo sapiens_hsa047210.79155005
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.75502366
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74612049
57Base excision repair_Homo sapiens_hsa034100.73826758
58Insulin secretion_Homo sapiens_hsa049110.73393437
59Cell cycle_Homo sapiens_hsa041100.73307884
60Circadian rhythm_Homo sapiens_hsa047100.70487069
61Glutamatergic synapse_Homo sapiens_hsa047240.70088018
62Arachidonic acid metabolism_Homo sapiens_hsa005900.69881526
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69661898
64One carbon pool by folate_Homo sapiens_hsa006700.69585831
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69217332
66Purine metabolism_Homo sapiens_hsa002300.68104701
67Histidine metabolism_Homo sapiens_hsa003400.67137372
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65938254
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65604477
70Cardiac muscle contraction_Homo sapiens_hsa042600.65119783
71Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64289554
72Proteasome_Homo sapiens_hsa030500.64197480
73beta-Alanine metabolism_Homo sapiens_hsa004100.61554763
74Fat digestion and absorption_Homo sapiens_hsa049750.59419218
75Dopaminergic synapse_Homo sapiens_hsa047280.57579355
76Alzheimers disease_Homo sapiens_hsa050100.56676324
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55711196
78Metabolic pathways_Homo sapiens_hsa011000.53365309
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51975589
80Nucleotide excision repair_Homo sapiens_hsa034200.48743836
81Mismatch repair_Homo sapiens_hsa034300.48158762
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47154330
83Calcium signaling pathway_Homo sapiens_hsa040200.46946961
84Pyrimidine metabolism_Homo sapiens_hsa002400.45950481
85Asthma_Homo sapiens_hsa053100.45944848
86Salivary secretion_Homo sapiens_hsa049700.44130744
87Non-homologous end-joining_Homo sapiens_hsa034500.43390232
88Graft-versus-host disease_Homo sapiens_hsa053320.43139016
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42099820
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41792621
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39821557
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39356788
93Long-term depression_Homo sapiens_hsa047300.39200011
94Type I diabetes mellitus_Homo sapiens_hsa049400.39068617
95cAMP signaling pathway_Homo sapiens_hsa040240.38089161
96Folate biosynthesis_Homo sapiens_hsa007900.36538039
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.35762866
98Fatty acid biosynthesis_Homo sapiens_hsa000610.35739918
99* Dorso-ventral axis formation_Homo sapiens_hsa043200.35372159
100Amphetamine addiction_Homo sapiens_hsa050310.34343828

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