PJA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.35964882
2nucleobase catabolic process (GO:0046113)5.32920236
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31679857
4synaptic vesicle exocytosis (GO:0016079)5.29079210
5neuron cell-cell adhesion (GO:0007158)5.25560885
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.89637020
7glutamate secretion (GO:0014047)4.84061265
8regulation of synaptic vesicle exocytosis (GO:2000300)4.74911480
9protein localization to synapse (GO:0035418)4.71397379
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.64792515
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.62645739
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.58637921
13regulation of glutamate receptor signaling pathway (GO:1900449)4.53050854
14synaptic vesicle maturation (GO:0016188)4.52219742
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43455547
16neurotransmitter-gated ion channel clustering (GO:0072578)4.43104859
17positive regulation of mitochondrial fission (GO:0090141)4.35093834
18establishment of mitochondrion localization (GO:0051654)4.34828974
19neurotransmitter secretion (GO:0007269)4.34773798
20locomotory exploration behavior (GO:0035641)4.21592121
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.15265629
22regulation of synaptic vesicle transport (GO:1902803)4.14698045
23neuronal action potential propagation (GO:0019227)3.96668680
24presynaptic membrane assembly (GO:0097105)3.95467847
25synaptic transmission, glutamatergic (GO:0035249)3.93311264
26neuron-neuron synaptic transmission (GO:0007270)3.93218361
27postsynaptic membrane organization (GO:0001941)3.88068162
28neuron recognition (GO:0008038)3.85826196
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79041433
30exploration behavior (GO:0035640)3.75181575
31glutamate receptor signaling pathway (GO:0007215)3.70795522
32regulation of neuronal synaptic plasticity (GO:0048168)3.69915442
33layer formation in cerebral cortex (GO:0021819)3.68565939
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67773665
35presynaptic membrane organization (GO:0097090)3.66323995
36gamma-aminobutyric acid transport (GO:0015812)3.64410704
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61005635
38positive regulation of synapse maturation (GO:0090129)3.59339934
39regulation of synapse structural plasticity (GO:0051823)3.53253701
40neurotransmitter transport (GO:0006836)3.52974666
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.51921057
42negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.49273230
43positive regulation of synapse assembly (GO:0051965)3.48864100
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.47237625
45calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.45780593
46startle response (GO:0001964)3.39787559
47synaptic vesicle endocytosis (GO:0048488)3.38655546
48axonal fasciculation (GO:0007413)3.38110407
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32833566
50long-term synaptic potentiation (GO:0060291)3.31699064
51regulation of neurotransmitter levels (GO:0001505)3.30592943
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.29356552
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28798435
54negative regulation of oligodendrocyte differentiation (GO:0048715)3.28120678
55neurofilament cytoskeleton organization (GO:0060052)3.27723041
56proline transport (GO:0015824)3.27554240
57pyrimidine nucleobase catabolic process (GO:0006208)3.26673138
58dendritic spine morphogenesis (GO:0060997)3.25547437
59regulation of postsynaptic membrane potential (GO:0060078)3.25120836
60hippocampus development (GO:0021766)3.24050608
61positive regulation of membrane potential (GO:0045838)3.23705161
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17641997
63regulation of neurotransmitter secretion (GO:0046928)3.15205510
64regulation of synaptic transmission, GABAergic (GO:0032228)3.10862078
65cerebral cortex radially oriented cell migration (GO:0021799)3.09148832
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.08453104
67regulation of synaptic plasticity (GO:0048167)3.08117522
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08012667
69glycosphingolipid biosynthetic process (GO:0006688)3.07459709
70transmission of nerve impulse (GO:0019226)3.06179955
71cerebellar granule cell differentiation (GO:0021707)3.04550199
72long-term memory (GO:0007616)3.04485122
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04225311
74synapse assembly (GO:0007416)3.03476845
75response to histamine (GO:0034776)3.03269008
76positive regulation of neurotransmitter transport (GO:0051590)3.02576999
77activation of protein kinase A activity (GO:0034199)3.01936291
78female mating behavior (GO:0060180)3.01573145
79regulation of female receptivity (GO:0045924)3.01171627
80neuronal ion channel clustering (GO:0045161)3.00340293
81behavioral response to cocaine (GO:0048148)2.99905507
82nonmotile primary cilium assembly (GO:0035058)2.99265961
83energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.98740424
84ATP hydrolysis coupled proton transport (GO:0015991)2.98740424
85behavioral fear response (GO:0001662)2.98218182
86behavioral defense response (GO:0002209)2.98218182
87membrane hyperpolarization (GO:0060081)2.95495148
88regulation of glutamate secretion (GO:0014048)2.95160617
89auditory behavior (GO:0031223)2.95046294
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94204389
91regulation of neurotransmitter transport (GO:0051588)2.93455603
92transferrin transport (GO:0033572)2.91617709
93DNA damage response, detection of DNA damage (GO:0042769)2.90806521
94regulation of synapse maturation (GO:0090128)2.90254112
95response to pheromone (GO:0019236)2.89700776
96cerebellar Purkinje cell differentiation (GO:0021702)2.89317120
97positive regulation of synaptic transmission (GO:0050806)2.88294738
98regulation of vesicle fusion (GO:0031338)2.87490708
99learning (GO:0007612)2.87019522
100neuromuscular process controlling posture (GO:0050884)2.86716360
101cell migration in hindbrain (GO:0021535)2.85981949
102synaptic vesicle transport (GO:0048489)2.85367198
103establishment of synaptic vesicle localization (GO:0097480)2.85367198
104regulation of synapse assembly (GO:0051963)2.84958353
105synaptic transmission (GO:0007268)2.84710691
106retinal ganglion cell axon guidance (GO:0031290)2.84334098
107regulation of respiratory system process (GO:0044065)2.84324515
108regulation of mitochondrial fission (GO:0090140)2.84260952
109mechanosensory behavior (GO:0007638)2.83211017
110dendrite morphogenesis (GO:0048813)2.82910073
111positive regulation of neurotransmitter secretion (GO:0001956)2.82759112
112membrane depolarization (GO:0051899)2.82012268
113limb bud formation (GO:0060174)2.81805350
114regulation of dendritic spine morphogenesis (GO:0061001)2.81163681
115protein polyglutamylation (GO:0018095)2.80999318
116fear response (GO:0042596)2.80702248
117establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.79900020
118mitochondrion transport along microtubule (GO:0047497)2.79900020
119central nervous system projection neuron axonogenesis (GO:0021952)2.79808984
120synapse organization (GO:0050808)2.78184741
121regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.76603130
122response to auditory stimulus (GO:0010996)2.70955584
123protein localization to cilium (GO:0061512)2.69345512
124sequestering of actin monomers (GO:0042989)2.68004778
125regulation of development, heterochronic (GO:0040034)2.65800296
126growth hormone secretion (GO:0030252)2.62753828
127protein insertion into membrane (GO:0051205)2.58967832
128neuromuscular synaptic transmission (GO:0007274)2.55343940
129short-term memory (GO:0007614)2.51650522
130dendritic spine organization (GO:0097061)2.51453665
131cytoskeleton-dependent intracellular transport (GO:0030705)2.49710979
132behavioral response to nicotine (GO:0035095)2.49087276
133DNA integration (GO:0015074)2.48858730
134olfactory bulb development (GO:0021772)2.48080696
135organelle transport along microtubule (GO:0072384)2.47954297
136negative regulation of microtubule polymerization (GO:0031115)2.47576166
137establishment of vesicle localization (GO:0051650)2.47005554
138axon extension (GO:0048675)2.46719237
139positive regulation of dendritic spine morphogenesis (GO:0061003)2.46648021
140substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.43712749
141substrate-independent telencephalic tangential migration (GO:0021826)2.43712749
142response to dietary excess (GO:0002021)2.42597719
143nervous system development (GO:0007399)2.42322166
144cullin deneddylation (GO:0010388)2.42084859
145cerebral cortex cell migration (GO:0021795)2.41093498
146positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.39843917
147mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.39843917
148regulation of feeding behavior (GO:0060259)2.39696888
149homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.39484974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37927310
2GBX2_23144817_ChIP-Seq_PC3_Human3.99190401
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12557330
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04126748
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96403107
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78079665
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.66458000
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.63146131
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60048493
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.60037222
11REST_21632747_ChIP-Seq_MESCs_Mouse2.58817977
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58590831
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58590831
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57939569
15TAF15_26573619_Chip-Seq_HEK293_Human2.55845048
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53566617
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52559499
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44799049
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40018904
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35458570
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.34452770
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.20508529
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20003861
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19950505
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.19619012
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.12997506
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.06872540
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05046649
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94681580
30DROSHA_22980978_ChIP-Seq_HELA_Human1.88281187
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87179186
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82675396
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79896704
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76033678
35* CBX2_27304074_Chip-Seq_ESCs_Mouse1.71511483
36SMAD4_21799915_ChIP-Seq_A2780_Human1.70994613
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65689914
38AR_21572438_ChIP-Seq_LNCaP_Human1.63520047
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60459002
40* P300_19829295_ChIP-Seq_ESCs_Human1.60193024
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59902162
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59683132
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59017195
44ZNF274_21170338_ChIP-Seq_K562_Hela1.57322975
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49939451
46RNF2_27304074_Chip-Seq_NSC_Mouse1.48907283
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47369618
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.45364027
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.44407890
50IGF1R_20145208_ChIP-Seq_DFB_Human1.43961154
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42222718
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40963679
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.40483136
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39215826
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38092099
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.37756782
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.37225228
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.36895220
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36416625
60EWS_26573619_Chip-Seq_HEK293_Human1.35796613
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35718798
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32330588
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29816759
64AR_25329375_ChIP-Seq_VCAP_Human1.28863907
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.28515593
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27659075
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.22100169
68IRF1_19129219_ChIP-ChIP_H3396_Human1.21992114
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19807037
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19434443
71FUS_26573619_Chip-Seq_HEK293_Human1.19238566
72STAT3_23295773_ChIP-Seq_U87_Human1.17633228
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17570222
74CBP_20019798_ChIP-Seq_JUKART_Human1.16873923
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16873923
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12189213
77ER_23166858_ChIP-Seq_MCF-7_Human1.11839197
78AR_19668381_ChIP-Seq_PC3_Human1.11043572
79VDR_22108803_ChIP-Seq_LS180_Human1.11001571
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10662933
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07632820
82RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06474763
83TCF4_23295773_ChIP-Seq_U87_Human1.05924996
84MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05583864
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04554443
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04304600
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04128235
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.02048063
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01814515
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.01750448
91* RUNX2_22187159_ChIP-Seq_PCA_Human1.00930484
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00540673
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00524507
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00459197
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99896240
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99006453
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98601011
98GABP_17652178_ChIP-ChIP_JURKAT_Human0.97075585
99JUN_21703547_ChIP-Seq_K562_Human0.96850514
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96771417
101THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96721136
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96680182
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.96361476
104MYC_18940864_ChIP-ChIP_HL60_Human0.94784357
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.94228996
106WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94228230
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93860652
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93860652
109AHR_22903824_ChIP-Seq_MCF-7_Human0.93458248
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92999946
111POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92983031
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92426754
113CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92050842
114TAL1_26923725_Chip-Seq_HPCs_Mouse0.89455407
115ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89395030
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88424995
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88372801
118CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88046418
119* SMAD3_21741376_ChIP-Seq_ESCs_Human0.88026378
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87613786
121BCAT_22108803_ChIP-Seq_LS180_Human0.87103200
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86727901
123ETS1_20019798_ChIP-Seq_JURKAT_Human0.86357910
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86173885
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86156526
126WT1_19549856_ChIP-ChIP_CCG9911_Human0.86034338
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85729605
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85676345
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.85599338
130SOX9_26525672_Chip-Seq_HEART_Mouse0.84073446
131KDM2B_26808549_Chip-Seq_REH_Human0.83681003
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83657756
133NANOG_18555785_Chip-Seq_ESCs_Mouse0.83138303
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83092402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.88285451
2MP0003880_abnormal_central_pattern4.71793682
3MP0003635_abnormal_synaptic_transmissio3.65871911
4MP0009745_abnormal_behavioral_response3.13427115
5MP0002063_abnormal_learning/memory/cond3.09609060
6MP0004270_analgesia3.07306062
7MP0001968_abnormal_touch/_nociception2.95746167
8MP0002064_seizures2.94160191
9MP0009046_muscle_twitch2.86242863
10MP0003122_maternal_imprinting2.74764401
11MP0002572_abnormal_emotion/affect_behav2.74203077
12MP0002102_abnormal_ear_morphology2.53836772
13MP0002736_abnormal_nociception_after2.53090004
14MP0005423_abnormal_somatic_nervous2.47857159
15MP0002822_catalepsy2.47185774
16MP0002272_abnormal_nervous_system2.46239076
17MP0006276_abnormal_autonomic_nervous2.44459888
18MP0002734_abnormal_mechanical_nocicepti2.41341553
19MP0002735_abnormal_chemical_nociception2.30289974
20MP0001486_abnormal_startle_reflex2.21481850
21MP0001440_abnormal_grooming_behavior2.14369901
22MP0001501_abnormal_sleep_pattern2.13247250
23MP0003787_abnormal_imprinting2.12718871
24MP0005646_abnormal_pituitary_gland2.07807047
25MP0002067_abnormal_sensory_capabilities2.01760759
26MP0009780_abnormal_chondrocyte_physiolo2.00232450
27MP0002733_abnormal_thermal_nociception1.95214688
28MP0000778_abnormal_nervous_system1.91415734
29MP0005645_abnormal_hypothalamus_physiol1.87499670
30MP0002184_abnormal_innervation1.86427398
31MP0002557_abnormal_social/conspecific_i1.84390493
32MP0001970_abnormal_pain_threshold1.82120039
33MP0001529_abnormal_vocalization1.79400497
34MP0000049_abnormal_middle_ear1.70479553
35MP0000013_abnormal_adipose_tissue1.67773840
36MP0005386_behavior/neurological_phenoty1.67060307
37MP0004924_abnormal_behavior1.67060307
38MP0003879_abnormal_hair_cell1.66923337
39MP0001984_abnormal_olfaction1.65019713
40MP0003329_amyloid_beta_deposits1.63374417
41MP0008995_early_reproductive_senescence1.60328582
42MP0002909_abnormal_adrenal_gland1.60245469
43MP0004811_abnormal_neuron_physiology1.55889591
44MP0000955_abnormal_spinal_cord1.44980837
45MP0001905_abnormal_dopamine_level1.44134113
46MP0002882_abnormal_neuron_morphology1.39508457
47MP0004142_abnormal_muscle_tone1.39393044
48MP0008569_lethality_at_weaning1.36607499
49MP0002066_abnormal_motor_capabilities/c1.34711940
50MP0010386_abnormal_urinary_bladder1.33976327
51MP0002234_abnormal_pharynx_morphology1.33473784
52MP0002837_dystrophic_cardiac_calcinosis1.33010335
53MP0004858_abnormal_nervous_system1.26570026
54MP0003121_genomic_imprinting1.26344341
55MP0003119_abnormal_digestive_system1.24642681
56MP0001502_abnormal_circadian_rhythm1.24517685
57MP0004133_heterotaxia1.20443225
58MP0000631_abnormal_neuroendocrine_gland1.20378179
59MP0000751_myopathy1.19699330
60MP0005248_abnormal_Harderian_gland1.19367459
61MP0004885_abnormal_endolymph1.18695466
62MP0003385_abnormal_body_wall1.18665032
63MP0001188_hyperpigmentation1.15073636
64MP0005551_abnormal_eye_electrophysiolog1.15051652
65MP0002233_abnormal_nose_morphology1.12630333
66MP0001299_abnormal_eye_distance/1.11848177
67MP0003136_yellow_coat_color1.10023622
68MP0002152_abnormal_brain_morphology1.08756294
69MP0004742_abnormal_vestibular_system1.06167280
70MP0002876_abnormal_thyroid_physiology1.06009459
71MP0003938_abnormal_ear_development1.05788555
72MP0005499_abnormal_olfactory_system1.04689058
73MP0005394_taste/olfaction_phenotype1.04689058
74MP0003890_abnormal_embryonic-extraembry1.03927991
75MP0003633_abnormal_nervous_system1.03667878
76MP0003221_abnormal_cardiomyocyte_apopto0.99055545
77MP0002069_abnormal_eating/drinking_beha0.98868273
78MP0002229_neurodegeneration0.96666648
79MP0003755_abnormal_palate_morphology0.92349865
80MP0003631_nervous_system_phenotype0.91727728
81MP0001963_abnormal_hearing_physiology0.90274349
82MP0001293_anophthalmia0.89291837
83MP0003937_abnormal_limbs/digits/tail_de0.88852538
84MP0000566_synostosis0.86944564
85MP0000647_abnormal_sebaceous_gland0.86166252
86MP0002752_abnormal_somatic_nervous0.86162572
87MP0004043_abnormal_pH_regulation0.84618040
88MP0005367_renal/urinary_system_phenotyp0.80939777
89MP0000516_abnormal_urinary_system0.80939777
90MP0002938_white_spotting0.80878993
91MP0001986_abnormal_taste_sensitivity0.79969116
92MP0004085_abnormal_heartbeat0.79608572
93MP0001177_atelectasis0.79168267
94MP0006072_abnormal_retinal_apoptosis0.78999030
95MP0003123_paternal_imprinting0.78939937
96MP0008877_abnormal_DNA_methylation0.78929461
97MP0003567_abnormal_fetal_cardiomyocyte0.78557874
98MP0002081_perinatal_lethality0.78497800
99MP0003283_abnormal_digestive_organ0.77630261
100MP0001664_abnormal_digestion0.75147973
101MP0005391_vision/eye_phenotype0.74751618
102MP0004145_abnormal_muscle_electrophysio0.74728389
103MP0008872_abnormal_physiological_respon0.74635565
104MP0002653_abnormal_ependyma_morphology0.74524246
105MP0003634_abnormal_glial_cell0.73944213
106MP0003137_abnormal_impulse_conducting0.72905399
107MP0002638_abnormal_pupillary_reflex0.72452800
108MP0002751_abnormal_autonomic_nervous0.71606702
109MP0005535_abnormal_body_temperature0.69540904
110MP0002090_abnormal_vision0.67592624
111MP0005253_abnormal_eye_physiology0.67427549
112MP0004233_abnormal_muscle_weight0.66602921
113MP0003632_abnormal_nervous_system0.66339382
114MP0003183_abnormal_peptide_metabolism0.63911204
115MP0000026_abnormal_inner_ear0.63315028
116MP0001943_abnormal_respiration0.62020890
117MP0005187_abnormal_penis_morphology0.60743970
118MP0003861_abnormal_nervous_system0.58601432
119MP0001485_abnormal_pinna_reflex0.58114002
120MP0006292_abnormal_olfactory_placode0.57704220
121MP0000604_amyloidosis0.57652780
122MP0008874_decreased_physiological_sensi0.56746311
123MP0008789_abnormal_olfactory_epithelium0.56525016
124MP0000534_abnormal_ureter_morphology0.55784488
125MP0002082_postnatal_lethality0.55746447
126MP0010770_preweaning_lethality0.55746447
127MP0000639_abnormal_adrenal_gland0.53467239

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.53082997
2Myokymia (HP:0002411)5.27577463
3Atonic seizures (HP:0010819)4.82819139
4Focal seizures (HP:0007359)4.79733128
5Epileptic encephalopathy (HP:0200134)4.58112229
6Cortical dysplasia (HP:0002539)4.30054392
7Visual hallucinations (HP:0002367)4.23595530
8Febrile seizures (HP:0002373)4.19855258
9Hyperventilation (HP:0002883)3.82189260
10Absence seizures (HP:0002121)3.75589375
11Progressive cerebellar ataxia (HP:0002073)3.73744297
12Pheochromocytoma (HP:0002666)3.44725765
13Generalized tonic-clonic seizures (HP:0002069)3.43246467
14Dialeptic seizures (HP:0011146)3.39200643
15Polyphagia (HP:0002591)3.32194632
16Limb dystonia (HP:0002451)3.25082603
17Ankle clonus (HP:0011448)3.20673132
18Failure to thrive in infancy (HP:0001531)3.17293968
19Abnormal eating behavior (HP:0100738)3.15850040
20Neuroendocrine neoplasm (HP:0100634)3.05777699
21Broad-based gait (HP:0002136)2.97543271
22Epileptiform EEG discharges (HP:0011182)2.82790066
23Amyotrophic lateral sclerosis (HP:0007354)2.82346168
24Drooling (HP:0002307)2.79197262
25Excessive salivation (HP:0003781)2.79197262
26Impaired vibration sensation in the lower limbs (HP:0002166)2.77729737
27Anxiety (HP:0000739)2.77620114
28Truncal ataxia (HP:0002078)2.74421053
29Poor eye contact (HP:0000817)2.72936998
30Amblyopia (HP:0000646)2.71590496
31EEG with generalized epileptiform discharges (HP:0011198)2.69349655
32Retinal dysplasia (HP:0007973)2.67604266
33Depression (HP:0000716)2.67248074
34Poor suck (HP:0002033)2.66179307
35Progressive inability to walk (HP:0002505)2.65267409
36Gait imbalance (HP:0002141)2.64335468
37Abnormal hair whorl (HP:0010721)2.60935984
38Gaze-evoked nystagmus (HP:0000640)2.57562058
39Split foot (HP:0001839)2.57193791
40Hypsarrhythmia (HP:0002521)2.57098886
41Supranuclear gaze palsy (HP:0000605)2.50927519
42Abnormal social behavior (HP:0012433)2.49510368
43Impaired social interactions (HP:0000735)2.49510368
44Agitation (HP:0000713)2.48929182
45Spastic tetraplegia (HP:0002510)2.47731471
46Action tremor (HP:0002345)2.47077783
47Hepatoblastoma (HP:0002884)2.45699825
48Dysdiadochokinesis (HP:0002075)2.45329034
49Pachygyria (HP:0001302)2.40574999
50Shoulder girdle muscle weakness (HP:0003547)2.37794725
51Ulnar claw (HP:0001178)2.37446814
52Hypoventilation (HP:0002791)2.36877331
53Torticollis (HP:0000473)2.36486372
54Blue irides (HP:0000635)2.34455167
55Optic nerve hypoplasia (HP:0000609)2.33570443
56Specific learning disability (HP:0001328)2.32450307
57Focal dystonia (HP:0004373)2.30636792
58Abnormality of the lower motor neuron (HP:0002366)2.29271645
59Spastic gait (HP:0002064)2.29095397
60Urinary bladder sphincter dysfunction (HP:0002839)2.28939410
61Termporal pattern (HP:0011008)2.28807853
62Insidious onset (HP:0003587)2.28807853
63Septo-optic dysplasia (HP:0100842)2.27699351
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26607008
65Degeneration of the lateral corticospinal tracts (HP:0002314)2.26607008
66Mutism (HP:0002300)2.25570427
67Esotropia (HP:0000565)2.25292895
68Medial flaring of the eyebrow (HP:0010747)2.24131284
69Congenital primary aphakia (HP:0007707)2.23449931
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21199946
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.20831393
72Hypoplasia of the brainstem (HP:0002365)2.20671459
73Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20671459
74Inability to walk (HP:0002540)2.15983316
75True hermaphroditism (HP:0010459)2.14902256
76Dysmetria (HP:0001310)2.13952857
77Craniofacial dystonia (HP:0012179)2.11367970
78Urinary urgency (HP:0000012)2.11292907
79Abnormality of the hip-girdle musculature (HP:0001445)2.10925711
80Abnormality of the musculature of the pelvis (HP:0001469)2.10925711
81Nephrogenic diabetes insipidus (HP:0009806)2.10722783
82Narrow nasal bridge (HP:0000446)2.10664125
83Hyperthyroidism (HP:0000836)2.10647536
84Oligomenorrhea (HP:0000876)2.06650344
85Peripheral hypomyelination (HP:0007182)2.05453456
86Protruding tongue (HP:0010808)2.04564841
87Fetal akinesia sequence (HP:0001989)2.03669135
88Lower limb muscle weakness (HP:0007340)2.02611076
89Neoplasm of the peripheral nervous system (HP:0100007)2.01892934
90Abnormal mitochondria in muscle tissue (HP:0008316)2.00046202
91Acute necrotizing encephalopathy (HP:0006965)1.99490338
92Broad foot (HP:0001769)1.98825562
93Hemiparesis (HP:0001269)1.97838841
94Cerebral inclusion bodies (HP:0100314)1.97598186
95Bradykinesia (HP:0002067)1.96247721
96Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95228716
97Lissencephaly (HP:0001339)1.94989329
98Scanning speech (HP:0002168)1.94256157
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94119226
100Absent speech (HP:0001344)1.93949705
101Abnormality of the corticospinal tract (HP:0002492)1.92124497
102Generalized hypotonia (HP:0001290)1.91171021
103Postural tremor (HP:0002174)1.88792393
104Intestinal atresia (HP:0011100)1.88337563
105Abnormality of the labia minora (HP:0012880)1.86723896
106Progressive macrocephaly (HP:0004481)1.86710501
107Sleep apnea (HP:0010535)1.85918435
108Type II lissencephaly (HP:0007260)1.85859194
109Resting tremor (HP:0002322)1.85815537
110Decreased testicular size (HP:0008734)1.85626480
111Abnormality of pain sensation (HP:0010832)1.84818286
112Impaired pain sensation (HP:0007328)1.84818286
113Diplopia (HP:0000651)1.84527877
114Abnormality of binocular vision (HP:0011514)1.84527877
115Morphological abnormality of the pyramidal tract (HP:0002062)1.84464922
116Vaginal atresia (HP:0000148)1.83061710
117Postaxial hand polydactyly (HP:0001162)1.82486668
118Genital tract atresia (HP:0001827)1.82171216
119Hypoplasia of the corpus callosum (HP:0002079)1.81734731
120Micropenis (HP:0000054)1.81556746
121Postural instability (HP:0002172)1.81458651
122Abnormality of salivation (HP:0100755)1.81415934
123Generalized myoclonic seizures (HP:0002123)1.80959584
124Neurofibrillary tangles (HP:0002185)1.80943137
125Psychosis (HP:0000709)1.80282430
126Intention tremor (HP:0002080)1.80012521
127Poor coordination (HP:0002370)1.78482615
128Impaired vibratory sensation (HP:0002495)1.77436208
129Gait ataxia (HP:0002066)1.77151461
130Pancreatic cysts (HP:0001737)1.76960559
131Neoplasm of the heart (HP:0100544)1.75499204
132Paraplegia (HP:0010550)1.72796616
133Abnormality of the metopic suture (HP:0005556)1.70972222
134Short tibia (HP:0005736)1.70767570
135Narrow forehead (HP:0000341)1.70070350
136Pelvic girdle muscle weakness (HP:0003749)1.69990673
137Hammertoe (HP:0001765)1.69607262
138Pancreatic fibrosis (HP:0100732)1.68714663
139Muscular hypotonia of the trunk (HP:0008936)1.66481055
140Medulloblastoma (HP:0002885)1.66227332
141Exotropia (HP:0000577)1.65521533
142Labial hypoplasia (HP:0000066)1.64673257
143Neonatal respiratory distress (HP:0002643)1.63959378
144Intellectual disability, moderate (HP:0002342)1.62048620
145Scrotal hypoplasia (HP:0000046)1.61727902
146Cerebral hypomyelination (HP:0006808)1.60980371
147Anophthalmia (HP:0000528)1.59268964
148Nephronophthisis (HP:0000090)1.59081403
149Occipital encephalocele (HP:0002085)1.59045483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.23068137
2NTRK33.84855943
3MARK13.36380399
4MAP3K43.24572324
5MAP3K122.89267794
6EPHA42.87338502
7MAP2K72.81462848
8TRIM282.78407643
9PRPF4B2.66051026
10MAP4K22.65147949
11MINK12.61579035
12MAP3K92.56174326
13EPHA32.33537578
14DAPK22.21694190
15SRPK12.06303211
16MAP2K42.03528663
17NTRK22.03498690
18CDK191.99471155
19PLK21.71759066
20SIK31.65112586
21PAK61.64575029
22BCKDK1.63556664
23BCR1.63138693
24DAPK11.59167599
25MAPK131.56936257
26WNK31.46243982
27CDK51.39782033
28GRK51.38916516
29EPHB21.37859361
30KSR11.36379626
31DYRK31.32242224
32OXSR11.30953528
33UHMK11.30616120
34AKT31.29453545
35PRKCG1.26229002
36TNIK1.25514314
37NTRK11.22327339
38TSSK61.15661064
39ARAF1.15387403
40PNCK1.14501571
41SGK4941.12411549
42SGK2231.12411549
43RPS6KA41.11749540
44CAMK2A1.08723584
45PRKD31.03977102
46TYRO31.01184518
47DYRK1B1.00346355
48FER0.99466261
49CDK180.97820537
50KSR20.96897928
51CSNK1G20.96437426
52PAK30.93910585
53CDK140.93570900
54SIK20.93262386
55TESK10.93189525
56CAMK2B0.92575580
57CAMKK10.90489279
58CDK150.89464892
59PHKG10.86295032
60PHKG20.86295032
61SGK20.86095596
62BRAF0.85190298
63DYRK1A0.84830216
64CCNB10.84442702
65NME10.80375130
66CSNK1G30.79202055
67PRKCE0.77704624
68CDK11A0.77677226
69CAMKK20.76096596
70FES0.75765999
71LIMK10.70931483
72PRKCH0.70739497
73PLK40.68312246
74PTK2B0.66386292
75DYRK20.65926851
76MKNK10.65779185
77PINK10.63547880
78LATS20.62430155
79STK380.61718135
80TNK20.61067970
81STK38L0.59730501
82NEK10.56667923
83ADRBK10.56217541
84RIPK40.56201356
85CSNK1A1L0.53141770
86MARK20.52862642
87WNK40.52793985
88SGK30.52618415
89BRD40.52565936
90MAP3K50.52322290
91CAMK2G0.51966980
92CAMK2D0.51310925
93PDK40.51250530
94PDK30.51250530
95MKNK20.51188499
96CAMK10.51103919
97RET0.50704455
98CAMK40.50485481
99TAOK10.49579341
100PKN10.49010860
101STK110.48485109
102SGK10.48121433
103ERBB30.48077478
104BMPR1B0.47258722
105PRKCZ0.46672739
106MYLK0.45228842
107CSNK1A10.45028852
108MAP3K20.44688516
109STK390.44456693
110RPS6KA20.43683483
111ROCK20.43614007
112ZAK0.43267135
113MAP2K10.43180210
114RPS6KA30.41259448
115DAPK30.40780096
116ADRBK20.40166587
117INSRR0.39893624
118MAPK90.39248681
119PLK30.38878907
120CSNK1G10.38811961
121CSNK1D0.38759239
122IRAK20.38412534
123ERBB40.38160528
124PIM20.38153913
125LMTK20.36968208
126ROCK10.36867138
127RPS6KA50.32411993
128PRKACA0.30994115
129PLK10.30837990
130PRKAA10.30241463
131PRKACB0.28607432
132VRK10.28156528
133CDK30.27403090
134EPHB10.26972590
135CSNK1E0.26509619
136AURKA0.25011688
137BRSK10.22877628

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.05312324
2Synaptic vesicle cycle_Homo sapiens_hsa047213.88317630
3GABAergic synapse_Homo sapiens_hsa047272.84158816
4Collecting duct acid secretion_Homo sapiens_hsa049662.74761287
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69991065
6Circadian entrainment_Homo sapiens_hsa047132.43447457
7Morphine addiction_Homo sapiens_hsa050322.41133651
8Olfactory transduction_Homo sapiens_hsa047402.34873737
9Amphetamine addiction_Homo sapiens_hsa050312.33168811
10Glutamatergic synapse_Homo sapiens_hsa047242.24288607
11Steroid biosynthesis_Homo sapiens_hsa001002.18702756
12Long-term potentiation_Homo sapiens_hsa047202.17951822
13Dopaminergic synapse_Homo sapiens_hsa047282.14003703
14Insulin secretion_Homo sapiens_hsa049111.93643468
15Taste transduction_Homo sapiens_hsa047421.91641238
16Vibrio cholerae infection_Homo sapiens_hsa051101.90445797
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86959987
18Cocaine addiction_Homo sapiens_hsa050301.80559042
19Protein export_Homo sapiens_hsa030601.80290614
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77338907
21Serotonergic synapse_Homo sapiens_hsa047261.72103307
22Salivary secretion_Homo sapiens_hsa049701.70351152
23Cholinergic synapse_Homo sapiens_hsa047251.65791946
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61903593
25Long-term depression_Homo sapiens_hsa047301.60448170
26Oxidative phosphorylation_Homo sapiens_hsa001901.59089658
27Renin secretion_Homo sapiens_hsa049241.53793697
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.52782499
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51282449
30Gastric acid secretion_Homo sapiens_hsa049711.46239281
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37692747
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32171463
33Calcium signaling pathway_Homo sapiens_hsa040201.30504844
34Oxytocin signaling pathway_Homo sapiens_hsa049211.30493772
35Axon guidance_Homo sapiens_hsa043601.29198598
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28692958
37Gap junction_Homo sapiens_hsa045401.28617747
38Fatty acid elongation_Homo sapiens_hsa000621.17766749
39Parkinsons disease_Homo sapiens_hsa050121.14101145
40Cardiac muscle contraction_Homo sapiens_hsa042601.12800222
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12175534
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11199534
43Propanoate metabolism_Homo sapiens_hsa006401.10444227
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08900132
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07738631
46Phototransduction_Homo sapiens_hsa047441.07340776
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07059142
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06848016
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06846410
50Alzheimers disease_Homo sapiens_hsa050101.06202709
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.05800546
52RNA polymerase_Homo sapiens_hsa030201.05434532
53GnRH signaling pathway_Homo sapiens_hsa049121.05187916
54cAMP signaling pathway_Homo sapiens_hsa040241.03453736
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03385378
56Hippo signaling pathway_Homo sapiens_hsa043900.99274677
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96790255
58Butanoate metabolism_Homo sapiens_hsa006500.95173499
59Estrogen signaling pathway_Homo sapiens_hsa049150.94904985
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94393303
61Type II diabetes mellitus_Homo sapiens_hsa049300.94003077
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90284492
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85921401
64ErbB signaling pathway_Homo sapiens_hsa040120.85634570
65Biosynthesis of amino acids_Homo sapiens_hsa012300.83697492
66Glioma_Homo sapiens_hsa052140.82016609
67Basal cell carcinoma_Homo sapiens_hsa052170.81936826
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81241093
69Melanogenesis_Homo sapiens_hsa049160.81033482
70Basal transcription factors_Homo sapiens_hsa030220.80267123
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79568407
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79370201
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77289238
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.77014166
75Spliceosome_Homo sapiens_hsa030400.75385307
76Regulation of autophagy_Homo sapiens_hsa041400.74477500
77beta-Alanine metabolism_Homo sapiens_hsa004100.73622570
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73470535
79Arginine and proline metabolism_Homo sapiens_hsa003300.69358460
80Pyruvate metabolism_Homo sapiens_hsa006200.69283162
81Base excision repair_Homo sapiens_hsa034100.69137266
82Huntingtons disease_Homo sapiens_hsa050160.68477199
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66398945
84Fanconi anemia pathway_Homo sapiens_hsa034600.65706139
85mRNA surveillance pathway_Homo sapiens_hsa030150.65640635
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62349836
87Tight junction_Homo sapiens_hsa045300.61531837
88Oocyte meiosis_Homo sapiens_hsa041140.59914817
89Peroxisome_Homo sapiens_hsa041460.58679717
90Type I diabetes mellitus_Homo sapiens_hsa049400.58365733
91RNA degradation_Homo sapiens_hsa030180.57501212
92Thyroid hormone synthesis_Homo sapiens_hsa049180.55214655
93Alcoholism_Homo sapiens_hsa050340.54195179
94Glucagon signaling pathway_Homo sapiens_hsa049220.54168579
95Rheumatoid arthritis_Homo sapiens_hsa053230.52065751
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51302826
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.51105156
98Pancreatic secretion_Homo sapiens_hsa049720.50569204
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50484816
100Vitamin B6 metabolism_Homo sapiens_hsa007500.50410051
101Endometrial cancer_Homo sapiens_hsa052130.48874970
102Carbon metabolism_Homo sapiens_hsa012000.48125879
103MAPK signaling pathway_Homo sapiens_hsa040100.47966306
104Dilated cardiomyopathy_Homo sapiens_hsa054140.47778286
105Prion diseases_Homo sapiens_hsa050200.46816455
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46738926
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.45942223
108Selenocompound metabolism_Homo sapiens_hsa004500.45731652
109Phagosome_Homo sapiens_hsa041450.45720671
110Ras signaling pathway_Homo sapiens_hsa040140.45622402
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45042792
112AMPK signaling pathway_Homo sapiens_hsa041520.44251523
113Choline metabolism in cancer_Homo sapiens_hsa052310.42804129
114Dorso-ventral axis formation_Homo sapiens_hsa043200.42526896
115Ether lipid metabolism_Homo sapiens_hsa005650.41613243
116Fatty acid metabolism_Homo sapiens_hsa012120.40765793
117RNA transport_Homo sapiens_hsa030130.39554444
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38827037
119Proteasome_Homo sapiens_hsa030500.37763762
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36439004
121Ovarian steroidogenesis_Homo sapiens_hsa049130.35497606
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35387124
123Wnt signaling pathway_Homo sapiens_hsa043100.35252578
124Sulfur relay system_Homo sapiens_hsa041220.34889997
125Bile secretion_Homo sapiens_hsa049760.34795912
126Insulin signaling pathway_Homo sapiens_hsa049100.34774323
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34419460
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33062223
129Renal cell carcinoma_Homo sapiens_hsa052110.32989725
130Metabolic pathways_Homo sapiens_hsa011000.32962387
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32559283
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.32208248
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.31787761
134Hedgehog signaling pathway_Homo sapiens_hsa043400.31266555
135Rap1 signaling pathway_Homo sapiens_hsa040150.31063771
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30362191
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28476918
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28270723
139Inositol phosphate metabolism_Homo sapiens_hsa005620.27299444
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26497290
141Circadian rhythm_Homo sapiens_hsa047100.24005179

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