PJA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49181374
2synaptic vesicle exocytosis (GO:0016079)5.20248995
3vocalization behavior (GO:0071625)5.17898098
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10434826
5synaptic vesicle maturation (GO:0016188)4.97364579
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95456325
7locomotory exploration behavior (GO:0035641)4.95055959
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.84922423
9regulation of synaptic vesicle exocytosis (GO:2000300)4.77668202
10glutamate secretion (GO:0014047)4.77370450
11neuron cell-cell adhesion (GO:0007158)4.62963588
12regulation of glutamate receptor signaling pathway (GO:1900449)4.59515104
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.44869805
14protein localization to synapse (GO:0035418)4.44282969
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.43667703
16neuronal action potential propagation (GO:0019227)4.42686780
17regulation of synaptic vesicle transport (GO:1902803)4.28990363
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.27126786
19neurotransmitter secretion (GO:0007269)4.24356242
20exploration behavior (GO:0035640)4.17848823
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.13524015
22glutamate receptor signaling pathway (GO:0007215)4.06448960
23regulation of neuronal synaptic plasticity (GO:0048168)4.04096158
24neuron-neuron synaptic transmission (GO:0007270)3.95061494
25synaptic transmission, glutamatergic (GO:0035249)3.93004195
26regulation of synapse structural plasticity (GO:0051823)3.91553521
27neurotransmitter-gated ion channel clustering (GO:0072578)3.75655748
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.74271957
29layer formation in cerebral cortex (GO:0021819)3.65884477
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.64687658
31neuron recognition (GO:0008038)3.63599465
32pyrimidine nucleobase catabolic process (GO:0006208)3.61964848
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.59203466
34positive regulation of synaptic transmission, GABAergic (GO:0032230)3.58034126
35gamma-aminobutyric acid transport (GO:0015812)3.57849041
36proline transport (GO:0015824)3.57234927
37L-amino acid import (GO:0043092)3.56420671
38regulation of postsynaptic membrane potential (GO:0060078)3.51978045
39activation of protein kinase A activity (GO:0034199)3.49731886
40dendritic spine morphogenesis (GO:0060997)3.47647187
41neuronal ion channel clustering (GO:0045161)3.47216454
42neurotransmitter transport (GO:0006836)3.47174002
43long-term synaptic potentiation (GO:0060291)3.46620392
44negative regulation of synaptic transmission, GABAergic (GO:0032229)3.42962237
45positive regulation of synapse maturation (GO:0090129)3.42885532
46* long-term memory (GO:0007616)3.41016821
47regulation of synaptic plasticity (GO:0048167)3.40293916
48positive regulation of membrane potential (GO:0045838)3.37633983
49cellular potassium ion homeostasis (GO:0030007)3.37495337
50synaptic vesicle endocytosis (GO:0048488)3.35430389
51regulation of dendritic spine morphogenesis (GO:0061001)3.32973428
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32531510
53presynaptic membrane assembly (GO:0097105)3.32317515
54amino acid import (GO:0043090)3.31048461
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.29916884
56transmission of nerve impulse (GO:0019226)3.29174609
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27608520
58regulation of vesicle fusion (GO:0031338)3.26630565
59axonal fasciculation (GO:0007413)3.25458740
60positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22710113
61postsynaptic membrane organization (GO:0001941)3.21929587
62regulation of neurotransmitter secretion (GO:0046928)3.21823552
63regulation of neurotransmitter levels (GO:0001505)3.21707654
64response to histamine (GO:0034776)3.17654353
65detection of calcium ion (GO:0005513)3.14461249
66vesicle transport along microtubule (GO:0047496)3.12674070
67presynaptic membrane organization (GO:0097090)3.12310456
68nucleobase catabolic process (GO:0046113)3.12061848
69behavioral fear response (GO:0001662)3.10638895
70behavioral defense response (GO:0002209)3.10638895
71G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.06989837
72potassium ion import (GO:0010107)3.05015132
73cerebellar Purkinje cell differentiation (GO:0021702)3.04893308
74mechanosensory behavior (GO:0007638)3.04629675
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04362230
76membrane depolarization (GO:0051899)3.04143917
77central nervous system projection neuron axonogenesis (GO:0021952)3.03601546
78membrane depolarization during action potential (GO:0086010)3.03490205
79innervation (GO:0060384)3.02731549
80positive regulation of neurotransmitter transport (GO:0051590)3.02553990
81regulation of neurotransmitter transport (GO:0051588)3.00791422
82positive regulation of neurotransmitter secretion (GO:0001956)3.00679887
83negative regulation of neurotransmitter transport (GO:0051589)3.00067684
84learning (GO:0007612)3.00046945
85fear response (GO:0042596)2.99459190
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97808689
87neuromuscular process controlling balance (GO:0050885)2.97640760
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96519478
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95701198
90positive regulation of synaptic transmission (GO:0050806)2.94755449
91neuromuscular process controlling posture (GO:0050884)2.94700642
92regulation of synaptic transmission, GABAergic (GO:0032228)2.94624106
93regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94373379
94synapse assembly (GO:0007416)2.94046815
95cellular sodium ion homeostasis (GO:0006883)2.93557185
96glycosphingolipid biosynthetic process (GO:0006688)2.93035601
97synaptic transmission (GO:0007268)2.92863884
98behavioral response to cocaine (GO:0048148)2.92706861
99mating behavior (GO:0007617)2.92642745
100neurotransmitter uptake (GO:0001504)2.91224282
101potassium ion homeostasis (GO:0055075)2.91163265
102nerve growth factor signaling pathway (GO:0038180)2.90828800
103response to auditory stimulus (GO:0010996)2.90475933
104auditory behavior (GO:0031223)2.89848681
105regulation of synaptic transmission (GO:0050804)2.88763600
106establishment of nucleus localization (GO:0040023)2.88561051
107prepulse inhibition (GO:0060134)2.87463242
108negative regulation of neurotransmitter secretion (GO:0046929)2.87326586
109dendrite morphogenesis (GO:0048813)2.85589352
110cell communication by electrical coupling (GO:0010644)2.85340693
111regulation of glutamate secretion (GO:0014048)2.84549245
112negative regulation of dendrite morphogenesis (GO:0050774)2.84459487
113striatum development (GO:0021756)2.84364573
114regulation of dendritic spine development (GO:0060998)2.84262875
115membrane hyperpolarization (GO:0060081)2.83104769
116sodium ion export (GO:0071436)2.82944156
117startle response (GO:0001964)2.82190592
118cerebellar granule cell differentiation (GO:0021707)2.81772055
119negative regulation of dendrite development (GO:2000171)2.79955735
120organelle transport along microtubule (GO:0072384)2.79907075
121regulation of voltage-gated calcium channel activity (GO:1901385)2.79527962
122establishment of mitochondrion localization (GO:0051654)2.78977749
123regulation of cell communication by electrical coupling (GO:0010649)2.78333290
124cerebral cortex radially oriented cell migration (GO:0021799)2.78266667
125clathrin coat assembly (GO:0048268)2.77662189
126positive regulation of dendritic spine morphogenesis (GO:0061003)2.77166626
127acidic amino acid transport (GO:0015800)2.76441734
128regulation of clathrin-mediated endocytosis (GO:2000369)2.73914518
129regulation of cAMP-dependent protein kinase activity (GO:2000479)2.72169479
130C4-dicarboxylate transport (GO:0015740)2.69134781
131establishment of synaptic vesicle localization (GO:0097480)2.67897207
132synaptic vesicle transport (GO:0048489)2.67897207
133positive regulation of dendritic spine development (GO:0060999)2.67113225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87879820
2GBX2_23144817_ChIP-Seq_PC3_Human3.80725877
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12587517
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05902085
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96193709
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63751708
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62364314
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62364314
9REST_21632747_ChIP-Seq_MESCs_Mouse2.61922133
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54100647
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51566027
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46832142
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45860264
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44274259
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.42928196
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.40328512
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.24700176
18DROSHA_22980978_ChIP-Seq_HELA_Human2.24594278
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11670371
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.10841809
21TAF15_26573619_Chip-Seq_HEK293_Human2.10817122
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.10162255
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05224424
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99408539
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98618540
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95547907
27AR_21572438_ChIP-Seq_LNCaP_Human1.87567531
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86689741
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86614421
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86256635
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83832018
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.79262538
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.70777527
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.66950260
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66233265
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64597372
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63781297
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.59613288
39ZNF274_21170338_ChIP-Seq_K562_Hela1.57376470
40P300_19829295_ChIP-Seq_ESCs_Human1.57024974
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56704062
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.54525492
43* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47006285
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43543693
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40809967
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.40293453
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39608809
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.38518335
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.36919699
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36792186
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35349194
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.35141446
53AR_25329375_ChIP-Seq_VCAP_Human1.34640381
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34087172
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33583141
56* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32940022
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32898806
58* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32061390
59* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32061390
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.31875467
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31825916
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30510796
63STAT3_23295773_ChIP-Seq_U87_Human1.29516879
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.28326610
65IGF1R_20145208_ChIP-Seq_DFB_Human1.26759007
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26673020
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23969752
68LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22316639
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21066606
70FUS_26573619_Chip-Seq_HEK293_Human1.19785359
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.19319792
72* AR_19668381_ChIP-Seq_PC3_Human1.17730929
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17061733
74* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15420012
75* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15410375
76TCF4_23295773_ChIP-Seq_U87_Human1.15375074
77STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14888614
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13513968
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.13462334
80P53_22387025_ChIP-Seq_ESCs_Mouse1.13353469
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.12876896
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.12633013
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.12141692
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11700839
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11700839
86* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10656092
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10318920
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.09837806
89RNF2_27304074_Chip-Seq_NSC_Mouse1.09248000
90* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08508497
91KDM2B_26808549_Chip-Seq_REH_Human1.08190455
92VDR_22108803_ChIP-Seq_LS180_Human1.07971362
93* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07573703
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07170746
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06998019
96AHR_22903824_ChIP-Seq_MCF-7_Human1.06470442
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05984044
98CBP_20019798_ChIP-Seq_JUKART_Human1.05984044
99* RUNX2_22187159_ChIP-Seq_PCA_Human1.05404836
100CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05107864
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04842936
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04480042
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04405758
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03978453
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.03419206
106ER_23166858_ChIP-Seq_MCF-7_Human1.01933942
107CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01892060
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01556673
109BCAT_22108803_ChIP-Seq_LS180_Human0.99850550
110TP53_16413492_ChIP-PET_HCT116_Human0.99173986
111RING1B_27294783_Chip-Seq_NPCs_Mouse0.97738812
112JUN_21703547_ChIP-Seq_K562_Human0.97405702
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96927627
114SMAD3_21741376_ChIP-Seq_ESCs_Human0.95347636
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93382392
116* TP53_18474530_ChIP-ChIP_U2OS_Human0.92950000
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92745224
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92691908
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.91179813
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.89877886
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88906001
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.88267476
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.85329565
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84910347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.89794271
2MP0003880_abnormal_central_pattern4.97045151
3MP0003635_abnormal_synaptic_transmissio4.01648466
4MP0004270_analgesia3.67874639
5MP0009745_abnormal_behavioral_response3.37748799
6MP0002063_abnormal_learning/memory/cond3.25601109
7MP0002064_seizures3.08259074
8MP0001968_abnormal_touch/_nociception3.04883946
9MP0009046_muscle_twitch3.02493358
10MP0002572_abnormal_emotion/affect_behav2.78784648
11MP0002822_catalepsy2.78283192
12MP0002734_abnormal_mechanical_nocicepti2.61472446
13MP0002272_abnormal_nervous_system2.56730836
14MP0002736_abnormal_nociception_after2.45036817
15MP0002735_abnormal_chemical_nociception2.39552138
16MP0001486_abnormal_startle_reflex2.38375401
17MP0001501_abnormal_sleep_pattern2.33908233
18MP0005423_abnormal_somatic_nervous2.32117268
19MP0001440_abnormal_grooming_behavior2.19040872
20MP0009780_abnormal_chondrocyte_physiolo2.16747836
21MP0002733_abnormal_thermal_nociception2.06517947
22MP0001970_abnormal_pain_threshold1.99960468
23MP0006276_abnormal_autonomic_nervous1.98060457
24MP0002067_abnormal_sensory_capabilities1.96972323
25MP0002909_abnormal_adrenal_gland1.87739305
26MP0003329_amyloid_beta_deposits1.84188804
27MP0002184_abnormal_innervation1.79711826
28MP0002837_dystrophic_cardiac_calcinosis1.79194638
29MP0005386_behavior/neurological_phenoty1.78197114
30MP0004924_abnormal_behavior1.78197114
31MP0008569_lethality_at_weaning1.70809058
32MP0000778_abnormal_nervous_system1.69952894
33MP0002557_abnormal_social/conspecific_i1.68494984
34MP0005646_abnormal_pituitary_gland1.65775623
35MP0001529_abnormal_vocalization1.63467463
36MP0004811_abnormal_neuron_physiology1.61230703
37MP0003121_genomic_imprinting1.59166689
38MP0004858_abnormal_nervous_system1.57975774
39MP0001984_abnormal_olfaction1.54927719
40MP0003122_maternal_imprinting1.54706651
41MP0010386_abnormal_urinary_bladder1.54070652
42MP0003787_abnormal_imprinting1.48518254
43MP0000013_abnormal_adipose_tissue1.46060344
44MP0000955_abnormal_spinal_cord1.45392332
45MP0003879_abnormal_hair_cell1.43902635
46MP0002066_abnormal_motor_capabilities/c1.37137417
47MP0001905_abnormal_dopamine_level1.37111671
48MP0005645_abnormal_hypothalamus_physiol1.34689377
49MP0001188_hyperpigmentation1.33697497
50MP0004145_abnormal_muscle_electrophysio1.32685547
51MP0002882_abnormal_neuron_morphology1.32246501
52MP0000751_myopathy1.31316533
53MP0008877_abnormal_DNA_methylation1.27346026
54MP0003633_abnormal_nervous_system1.25022189
55MP0004142_abnormal_muscle_tone1.16317580
56MP0005248_abnormal_Harderian_gland1.16280313
57MP0004885_abnormal_endolymph1.14471272
58MP0001502_abnormal_circadian_rhythm1.14359656
59MP0003631_nervous_system_phenotype1.04381877
60MP0002152_abnormal_brain_morphology0.99919496
61MP0004215_abnormal_myocardial_fiber0.97989109
62MP0004085_abnormal_heartbeat0.97866095
63MP0005535_abnormal_body_temperature0.94907515
64MP0008872_abnormal_physiological_respon0.91544043
65MP0002069_abnormal_eating/drinking_beha0.91230612
66MP0002229_neurodegeneration0.90991203
67MP0004484_altered_response_of0.88856266
68MP0005551_abnormal_eye_electrophysiolog0.87042500
69MP0002876_abnormal_thyroid_physiology0.83993213
70MP0008874_decreased_physiological_sensi0.83752374
71MP0001177_atelectasis0.82212386
72MP0004742_abnormal_vestibular_system0.81943836
73MP0003283_abnormal_digestive_organ0.80595241
74MP0001986_abnormal_taste_sensitivity0.78795107
75MP0000604_amyloidosis0.77885623
76MP0003634_abnormal_glial_cell0.77609459
77MP0001963_abnormal_hearing_physiology0.75478318
78MP0000631_abnormal_neuroendocrine_gland0.74069183
79MP0005253_abnormal_eye_physiology0.73269213
80MP0004233_abnormal_muscle_weight0.72034203
81MP0004043_abnormal_pH_regulation0.71399915
82MP0003632_abnormal_nervous_system0.70609693
83MP0005499_abnormal_olfactory_system0.70374197
84MP0005394_taste/olfaction_phenotype0.70374197
85MP0003137_abnormal_impulse_conducting0.68562848
86MP0001664_abnormal_digestion0.68359714
87MP0002752_abnormal_somatic_nervous0.68352659
88MP0002102_abnormal_ear_morphology0.67494364
89MP0005623_abnormal_meninges_morphology0.66465678
90MP0000569_abnormal_digit_pigmentation0.65208281
91MP0003861_abnormal_nervous_system0.65081738
92MP0002090_abnormal_vision0.64885194
93MP0008961_abnormal_basal_metabolism0.64107012
94MP0001299_abnormal_eye_distance/0.63569245
95MP0004036_abnormal_muscle_relaxation0.63099733
96MP0002638_abnormal_pupillary_reflex0.62405919
97MP0000920_abnormal_myelination0.61410006
98MP0005171_absent_coat_pigmentation0.61080405
99MP0003690_abnormal_glial_cell0.60734125
100MP0003123_paternal_imprinting0.58444221
101MP0005409_darkened_coat_color0.58272704
102MP0001943_abnormal_respiration0.58094374
103MP0005620_abnormal_muscle_contractility0.57590919
104MP0002082_postnatal_lethality0.56954719
105MP0010770_preweaning_lethality0.56954719
106MP0005388_respiratory_system_phenotype0.56678468
107MP0002133_abnormal_respiratory_system0.56678468
108MP0010769_abnormal_survival0.56603621
109MP0005187_abnormal_penis_morphology0.56598670
110MP0000639_abnormal_adrenal_gland0.55723131
111MP0006072_abnormal_retinal_apoptosis0.55224144
112MP0003385_abnormal_body_wall0.54016588
113MP0004130_abnormal_muscle_cell0.53481163
114MP0000747_muscle_weakness0.53237228
115MP0000534_abnormal_ureter_morphology0.53211713
116MP0003075_altered_response_to0.53169306
117MP0001485_abnormal_pinna_reflex0.52109817
118MP0002234_abnormal_pharynx_morphology0.51280416

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.72659569
2Myokymia (HP:0002411)6.17016017
3Focal seizures (HP:0007359)5.62031086
4Visual hallucinations (HP:0002367)5.13944268
5Atonic seizures (HP:0010819)5.07490018
6Epileptic encephalopathy (HP:0200134)4.77409814
7Febrile seizures (HP:0002373)4.43669747
8Absence seizures (HP:0002121)4.38679620
9Progressive cerebellar ataxia (HP:0002073)4.14940368
10Dialeptic seizures (HP:0011146)3.94730065
11Generalized tonic-clonic seizures (HP:0002069)3.88662838
12Hyperventilation (HP:0002883)3.68636924
13Action tremor (HP:0002345)3.63341059
14Broad-based gait (HP:0002136)3.49344768
15Papillary thyroid carcinoma (HP:0002895)3.36073106
16Supranuclear gaze palsy (HP:0000605)3.34686320
17Poor eye contact (HP:0000817)3.16560373
18Depression (HP:0000716)3.13815944
19Anxiety (HP:0000739)3.13126573
20Truncal ataxia (HP:0002078)3.12270950
21Gaze-evoked nystagmus (HP:0000640)3.09643617
22Amblyopia (HP:0000646)3.03210313
23Pheochromocytoma (HP:0002666)3.02671009
24Impaired vibration sensation in the lower limbs (HP:0002166)3.00044730
25Dysdiadochokinesis (HP:0002075)2.98868185
26Ankle clonus (HP:0011448)2.97120829
27Impaired social interactions (HP:0000735)2.88429452
28Abnormal social behavior (HP:0012433)2.88429452
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.83957090
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.83957090
31Dysmetria (HP:0001310)2.83024611
32Abnormal eating behavior (HP:0100738)2.82238384
33Progressive inability to walk (HP:0002505)2.76235137
34Cerebral inclusion bodies (HP:0100314)2.75298696
35Excessive salivation (HP:0003781)2.72531159
36Drooling (HP:0002307)2.72531159
37Urinary bladder sphincter dysfunction (HP:0002839)2.69669735
38Papilledema (HP:0001085)2.69421982
39Neuroendocrine neoplasm (HP:0100634)2.66578373
40Termporal pattern (HP:0011008)2.63938114
41Insidious onset (HP:0003587)2.63938114
42Epileptiform EEG discharges (HP:0011182)2.60658093
43Limb dystonia (HP:0002451)2.57665754
44Scanning speech (HP:0002168)2.57103887
45Neurofibrillary tangles (HP:0002185)2.55904863
46Mutism (HP:0002300)2.53537215
47Postural instability (HP:0002172)2.48079457
48Urinary urgency (HP:0000012)2.47820110
49EEG with generalized epileptiform discharges (HP:0011198)2.46045328
50Diplopia (HP:0000651)2.45341171
51Abnormality of binocular vision (HP:0011514)2.45341171
52Impaired smooth pursuit (HP:0007772)2.44348150
53Hemiparesis (HP:0001269)2.42963849
54Genetic anticipation (HP:0003743)2.42776807
55Abnormality of the lower motor neuron (HP:0002366)2.39047900
56Torticollis (HP:0000473)2.36538466
57Fetal akinesia sequence (HP:0001989)2.35086477
58Bradykinesia (HP:0002067)2.34045245
59Hypsarrhythmia (HP:0002521)2.29965642
60Absent speech (HP:0001344)2.25483298
61Focal dystonia (HP:0004373)2.24867133
62Hammertoe (HP:0001765)2.24190121
63Stereotypic behavior (HP:0000733)2.24172743
64Inability to walk (HP:0002540)2.21781569
65Spastic gait (HP:0002064)2.21380410
66Agitation (HP:0000713)2.20175709
67Thyroid carcinoma (HP:0002890)2.20006406
68Dysmetric saccades (HP:0000641)2.17519334
69Polyphagia (HP:0002591)2.15597238
70Abnormality of the corticospinal tract (HP:0002492)2.14310068
71Blue irides (HP:0000635)2.11772841
72Morphological abnormality of the pyramidal tract (HP:0002062)2.11473017
73Abnormality of ocular smooth pursuit (HP:0000617)2.09206787
74Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07584346
75Megalencephaly (HP:0001355)2.06877117
76Intention tremor (HP:0002080)2.05765127
77Peripheral hypomyelination (HP:0007182)2.05560949
78Lower limb muscle weakness (HP:0007340)2.04408044
79Gait imbalance (HP:0002141)2.03766363
80Status epilepticus (HP:0002133)2.03400283
81Clonus (HP:0002169)2.03033007
82Thickened helices (HP:0000391)2.02316688
83Craniofacial dystonia (HP:0012179)2.02147053
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.00701316
85Spastic tetraplegia (HP:0002510)2.00358245
86Generalized myoclonic seizures (HP:0002123)2.00076209
87Failure to thrive in infancy (HP:0001531)1.99976974
88Hypoventilation (HP:0002791)1.99032292
89Impaired vibratory sensation (HP:0002495)1.98730325
90Resting tremor (HP:0002322)1.97183754
91Ventricular fibrillation (HP:0001663)1.96920700
92Amyotrophic lateral sclerosis (HP:0007354)1.95994458
93Neoplasm of the peripheral nervous system (HP:0100007)1.95687724
94Tetraplegia (HP:0002445)1.94006272
95Gait ataxia (HP:0002066)1.93783694
96Sleep apnea (HP:0010535)1.93755756
97Protruding tongue (HP:0010808)1.92928904
98Hypoplasia of the corpus callosum (HP:0002079)1.91286385
99Paraplegia (HP:0010550)1.90839170
100Psychosis (HP:0000709)1.89821817
101Delusions (HP:0000746)1.89606908
102Hemiplegia (HP:0002301)1.89193015
103Spastic paraplegia (HP:0001258)1.85695045
104Inappropriate behavior (HP:0000719)1.82968027
105Split foot (HP:0001839)1.82604039
106Rapidly progressive (HP:0003678)1.81743755
107Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.81569929
108Abnormality of salivation (HP:0100755)1.81346533
109Incomplete penetrance (HP:0003829)1.80204888
110Congenital primary aphakia (HP:0007707)1.77878014
111Neuronal loss in central nervous system (HP:0002529)1.77554265
112Hyperthyroidism (HP:0000836)1.74512010
113Menstrual irregularities (HP:0000858)1.73803959
114Ulnar claw (HP:0001178)1.73515196
115Impaired pain sensation (HP:0007328)1.73249615
116Abnormality of pain sensation (HP:0010832)1.73249615
117Specific learning disability (HP:0001328)1.72964082
118Akinesia (HP:0002304)1.71855314
119Abnormal EKG (HP:0003115)1.71730125
120Exercise-induced muscle cramps (HP:0003710)1.71022032
121Obstructive sleep apnea (HP:0002870)1.70840242
122Lower limb asymmetry (HP:0100559)1.70813413
123Heterochromia iridis (HP:0001100)1.70697673
124Hepatoblastoma (HP:0002884)1.70318405
125Postural tremor (HP:0002174)1.69250368
126Rigidity (HP:0002063)1.69085123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.48393627
2EPHA44.22685769
3MAP3K93.45129138
4MAP3K43.13472010
5MARK12.76455245
6MAP2K72.74527349
7MAP3K122.68455645
8MINK12.65936804
9CASK2.48536594
10RIPK42.36469162
11DAPK22.23848517
12MAP2K42.11928782
13KSR22.08478388
14NTRK12.01342496
15ERBB31.84692730
16PAK61.80416254
17PNCK1.73546888
18NTRK21.71471805
19PLK21.70571626
20KSR11.62143575
21PRKD31.57402666
22DAPK11.54568088
23ARAF1.54321700
24GRK51.51881694
25CAMKK11.51424343
26CDK51.48814535
27EPHA31.38835478
28TNIK1.33713990
29MAP3K21.30882817
30CDK191.30180484
31MAPK131.24257546
32PRKCG1.21068942
33CAMKK21.17680141
34FRK1.14814577
35STK381.11396926
36CAMK2A1.09890455
37PRPF4B1.07621305
38MAP3K131.07604004
39BMPR21.07129349
40SIK21.06043837
41FES1.05815391
42PHKG21.02870041
43PHKG11.02870041
44UHMK11.02197791
45TRIM281.01609885
46PTK2B1.00765823
47FGFR20.95187348
48CAMK2B0.93890566
49SGK4940.91376679
50SGK2230.91376679
51BRD40.90690936
52LATS20.88895148
53RET0.88358266
54PAK30.84718990
55CDK180.83427215
56OXSR10.83014097
57CDK140.82554719
58NEK60.82155288
59CDK150.79898123
60SGK20.79728543
61CSNK1A1L0.78964631
62RAF10.78559836
63NME10.78231661
64LMTK20.76228277
65TYRO30.76012846
66CAMK10.75792681
67STK38L0.74517513
68PRKCH0.73738451
69MAP3K60.73730175
70FER0.73714282
71AKT30.73058706
72MAP3K10.72570296
73YES10.68964634
74CSNK1G30.68125217
75CSNK1G20.68112094
76SGK10.67785056
77PRKCE0.67635607
78CDK11A0.67583691
79STK110.67400393
80CSNK1G10.66869773
81DYRK1A0.65336946
82CAMK2D0.64058229
83PINK10.62950832
84SGK30.61658275
85MAP4K20.60880330
86PKN10.59040447
87BMPR1B0.56995836
88CAMK40.56348600
89MAP2K10.56177289
90TAOK10.55593235
91CCNB10.55049414
92PDPK10.54899318
93PDK10.53952491
94PDGFRA0.53472403
95WNK10.53466186
96FGR0.52234037
97WNK30.52045355
98FGFR30.51913204
99PDK40.51667721
100PDK30.51667721
101TNK20.50103114
102CAMK2G0.49575251
103DYRK1B0.48174727
104MARK20.46783153
105DYRK20.46617423
106MAP3K50.46288884
107CAMK1G0.45820038
108SCYL20.45429829
109GRK70.44878463
110JAK10.44845478
111WNK40.44550562
112PRKCZ0.44185585
113RPS6KA30.43880479
114PDGFRB0.42946381
115ROCK20.42721358
116PRKG10.42656610
117DMPK0.42014604
118CDC42BPA0.41709825
119ERBB20.41389157
120ROCK10.40585767
121BRAF0.40219875
122FYN0.40200932
123BCR0.39747744
124SIK30.39567138
125MAPK100.38798024
126DAPK30.34665386
127RPS6KA20.33636121
128STK390.32890122
129ADRBK10.32577364

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67622366
2Synaptic vesicle cycle_Homo sapiens_hsa047213.24232679
3Long-term potentiation_Homo sapiens_hsa047202.73009073
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.68769462
5GABAergic synapse_Homo sapiens_hsa047272.63633212
6Circadian entrainment_Homo sapiens_hsa047132.62243264
7Olfactory transduction_Homo sapiens_hsa047402.57212075
8Amphetamine addiction_Homo sapiens_hsa050312.53169794
9Glutamatergic synapse_Homo sapiens_hsa047242.43333586
10Morphine addiction_Homo sapiens_hsa050322.42707851
11Dopaminergic synapse_Homo sapiens_hsa047282.21651076
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15689059
13Salivary secretion_Homo sapiens_hsa049702.09836896
14Insulin secretion_Homo sapiens_hsa049112.04018601
15Collecting duct acid secretion_Homo sapiens_hsa049661.90646676
16Renin secretion_Homo sapiens_hsa049241.87220126
17Gastric acid secretion_Homo sapiens_hsa049711.83983715
18Taste transduction_Homo sapiens_hsa047421.83820985
19Cholinergic synapse_Homo sapiens_hsa047251.82969363
20Long-term depression_Homo sapiens_hsa047301.76913175
21Serotonergic synapse_Homo sapiens_hsa047261.76095379
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72444080
23Cocaine addiction_Homo sapiens_hsa050301.65467847
24Oxytocin signaling pathway_Homo sapiens_hsa049211.62011322
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61841609
26Calcium signaling pathway_Homo sapiens_hsa040201.58316145
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57402742
28GnRH signaling pathway_Homo sapiens_hsa049121.42272971
29Gap junction_Homo sapiens_hsa045401.33761741
30Vibrio cholerae infection_Homo sapiens_hsa051101.30149890
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25589566
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24348930
33cAMP signaling pathway_Homo sapiens_hsa040241.20795637
34Cardiac muscle contraction_Homo sapiens_hsa042601.19489444
35Estrogen signaling pathway_Homo sapiens_hsa049151.15387402
36Type II diabetes mellitus_Homo sapiens_hsa049301.12256513
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08056255
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07708134
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06743867
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06573137
41Glioma_Homo sapiens_hsa052141.05146035
42Melanogenesis_Homo sapiens_hsa049161.02624949
43Axon guidance_Homo sapiens_hsa043601.01805483
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99005880
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.98568698
46Phototransduction_Homo sapiens_hsa047440.91055557
47ErbB signaling pathway_Homo sapiens_hsa040120.90396878
48Alzheimers disease_Homo sapiens_hsa050100.88599088
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86970717
50Pancreatic secretion_Homo sapiens_hsa049720.86340382
51Oxidative phosphorylation_Homo sapiens_hsa001900.85746820
52Dilated cardiomyopathy_Homo sapiens_hsa054140.82264425
53Dorso-ventral axis formation_Homo sapiens_hsa043200.81548918
54Oocyte meiosis_Homo sapiens_hsa041140.81546075
55Thyroid hormone synthesis_Homo sapiens_hsa049180.80456168
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76182732
57Glucagon signaling pathway_Homo sapiens_hsa049220.72964574
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71611625
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.70796808
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70220636
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70116565
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67173035
63Parkinsons disease_Homo sapiens_hsa050120.64758551
64MAPK signaling pathway_Homo sapiens_hsa040100.63433252
65Choline metabolism in cancer_Homo sapiens_hsa052310.63327668
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62935206
67Type I diabetes mellitus_Homo sapiens_hsa049400.59352268
68VEGF signaling pathway_Homo sapiens_hsa043700.56676818
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56283634
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56226969
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54504920
72Prolactin signaling pathway_Homo sapiens_hsa049170.53905054
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.53396183
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53046854
75Ras signaling pathway_Homo sapiens_hsa040140.52656196
76AMPK signaling pathway_Homo sapiens_hsa041520.51234508
77Butanoate metabolism_Homo sapiens_hsa006500.49504914
78Regulation of autophagy_Homo sapiens_hsa041400.49216938
79Adherens junction_Homo sapiens_hsa045200.49014757
80Rap1 signaling pathway_Homo sapiens_hsa040150.48806141
81Fatty acid biosynthesis_Homo sapiens_hsa000610.48249601
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48223248
83Colorectal cancer_Homo sapiens_hsa052100.47504666
84Alcoholism_Homo sapiens_hsa050340.47466168
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.45101245
86Prion diseases_Homo sapiens_hsa050200.44078993
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43541783
88Insulin signaling pathway_Homo sapiens_hsa049100.43296367
89Inositol phosphate metabolism_Homo sapiens_hsa005620.43127361
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42036837
91mTOR signaling pathway_Homo sapiens_hsa041500.41405112
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41190064
93Circadian rhythm_Homo sapiens_hsa047100.41136373
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40028820
95Renal cell carcinoma_Homo sapiens_hsa052110.38671613
96Wnt signaling pathway_Homo sapiens_hsa043100.38534912
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38433280
98Tight junction_Homo sapiens_hsa045300.38430804
99Endocytosis_Homo sapiens_hsa041440.38264811
100FoxO signaling pathway_Homo sapiens_hsa040680.37936146
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36848499
102Huntingtons disease_Homo sapiens_hsa050160.36755145
103African trypanosomiasis_Homo sapiens_hsa051430.36659554
104Endometrial cancer_Homo sapiens_hsa052130.36195547
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36008310
106Vitamin B6 metabolism_Homo sapiens_hsa007500.35711210
107HIF-1 signaling pathway_Homo sapiens_hsa040660.35340061
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34946328
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34639329
110Rheumatoid arthritis_Homo sapiens_hsa053230.34320286
111Ovarian steroidogenesis_Homo sapiens_hsa049130.34282968
112Hippo signaling pathway_Homo sapiens_hsa043900.34136543
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33999527
114Propanoate metabolism_Homo sapiens_hsa006400.33181972
115Bile secretion_Homo sapiens_hsa049760.32474703
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32387950
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32063916
118Non-small cell lung cancer_Homo sapiens_hsa052230.32008497

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