PKD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glutamate secretion (GO:0014047)5.58536927
2synaptic vesicle exocytosis (GO:0016079)5.26470237
3cerebellar granule cell differentiation (GO:0021707)4.95366708
4regulation of synaptic vesicle exocytosis (GO:2000300)4.73762178
5neurotransmitter secretion (GO:0007269)4.21557677
6regulation of synapse maturation (GO:0090128)4.03162220
7regulation of synaptic vesicle transport (GO:1902803)3.92692701
8regulation of neuronal synaptic plasticity (GO:0048168)3.89011442
9neuronal ion channel clustering (GO:0045161)3.85036940
10plasma membrane repair (GO:0001778)3.83095184
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.70250580
12cytoskeletal anchoring at plasma membrane (GO:0007016)3.55152130
13neuronal action potential propagation (GO:0019227)3.54850997
14regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53381048
15L-amino acid import (GO:0043092)3.48325185
16ionotropic glutamate receptor signaling pathway (GO:0035235)3.46235238
17amino acid import (GO:0043090)3.38451060
18locomotory exploration behavior (GO:0035641)3.36704492
19establishment of nucleus localization (GO:0040023)3.34909744
20dendritic spine morphogenesis (GO:0060997)3.32494385
21cell migration in hindbrain (GO:0021535)3.31784755
22sodium ion export (GO:0071436)3.25438214
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24485879
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23781989
25regulation of glutamate receptor signaling pathway (GO:1900449)3.23524477
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.22863537
27synaptic vesicle endocytosis (GO:0048488)3.21496378
28exploration behavior (GO:0035640)3.21403749
29neurotransmitter transport (GO:0006836)3.20119307
30postsynaptic membrane organization (GO:0001941)3.19923742
31potassium ion homeostasis (GO:0055075)3.09538763
32neurotransmitter-gated ion channel clustering (GO:0072578)3.08954057
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.07163489
34regulation of synaptic plasticity (GO:0048167)3.05897043
35cell differentiation in hindbrain (GO:0021533)3.03389097
36protein heterotrimerization (GO:0070208)3.02996299
37synaptic vesicle maturation (GO:0016188)3.02279347
38positive regulation of membrane potential (GO:0045838)3.02250556
39positive regulation of dendritic spine development (GO:0060999)3.01882007
40cell communication by electrical coupling (GO:0010644)3.01425619
41regulation of p38MAPK cascade (GO:1900744)3.00455960
42activation of protein kinase A activity (GO:0034199)2.92887202
43regulation of vesicle fusion (GO:0031338)2.91378361
44auditory behavior (GO:0031223)2.90689381
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.90262160
46regulation of neurotransmitter levels (GO:0001505)2.88236962
47dendritic spine organization (GO:0097061)2.86819864
48regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86636428
49regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86212561
50regulation of neurotransmitter secretion (GO:0046928)2.84841435
51positive regulation of p38MAPK cascade (GO:1900745)2.84474244
52synaptic transmission, glutamatergic (GO:0035249)2.84131360
53long-term memory (GO:0007616)2.83280595
54stress fiber assembly (GO:0043149)2.83273281
55regulation of voltage-gated calcium channel activity (GO:1901385)2.83223499
56neuromuscular process controlling posture (GO:0050884)2.82868689
57collagen fibril organization (GO:0030199)2.82739628
58regulation of ARF protein signal transduction (GO:0032012)2.82130078
59axon ensheathment in central nervous system (GO:0032291)2.82031973
60central nervous system myelination (GO:0022010)2.82031973
61positive regulation of histone deacetylation (GO:0031065)2.79366897
62positive regulation of dendrite development (GO:1900006)2.77783392
63semaphorin-plexin signaling pathway (GO:0071526)2.74577120
64layer formation in cerebral cortex (GO:0021819)2.74444740
65regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74328248
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.74064820
67positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73930183
68protein localization to synapse (GO:0035418)2.72563933
69negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70105001
70synaptic vesicle docking involved in exocytosis (GO:0016081)2.70060597
71regulation of postsynaptic membrane potential (GO:0060078)2.68620713
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.68447578
73axon extension involved in axon guidance (GO:0048846)2.68447578
74apoptotic cell clearance (GO:0043277)2.61605010
75positive regulation of neurotransmitter transport (GO:0051590)2.60032454
76negative regulation of dendrite morphogenesis (GO:0050774)2.59697447
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59269894
78cellular potassium ion homeostasis (GO:0030007)2.59087954
79glutamate receptor signaling pathway (GO:0007215)2.56459119
80positive regulation of glycogen biosynthetic process (GO:0045725)2.56255992
81regulation of synapse structural plasticity (GO:0051823)2.55928479
82potassium ion import (GO:0010107)2.55113201
83chemosensory behavior (GO:0007635)2.53528601
84membrane depolarization (GO:0051899)2.52917133
85establishment of protein localization to Golgi (GO:0072600)2.52832624
86regulation of neurotransmitter transport (GO:0051588)2.52310047
87myelination in peripheral nervous system (GO:0022011)2.49484732
88peripheral nervous system axon ensheathment (GO:0032292)2.49484732
89neuromuscular synaptic transmission (GO:0007274)2.47637418
90regulation of dendrite morphogenesis (GO:0048814)2.47377405
91dopamine receptor signaling pathway (GO:0007212)2.47235555
92peptidyl-tyrosine autophosphorylation (GO:0038083)2.46296881
93cardiac myofibril assembly (GO:0055003)2.45973089
94neuromuscular process (GO:0050905)2.45874041
95protein targeting to Golgi (GO:0000042)2.45458722
96sequestering of extracellular ligand from receptor (GO:0035581)2.44257646
97vascular endothelial growth factor signaling pathway (GO:0038084)2.43778375
98neuron-neuron synaptic transmission (GO:0007270)2.43010929
99regulation of dendritic spine morphogenesis (GO:0061001)2.42947000
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42842873
101positive regulation of neurotransmitter secretion (GO:0001956)2.42497763
102adherens junction assembly (GO:0034333)2.41717936
103cerebellar Purkinje cell differentiation (GO:0021702)2.41340916
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41243051
105dendrite morphogenesis (GO:0048813)2.40540111
106response to auditory stimulus (GO:0010996)2.40280905
107positive regulation of fibroblast migration (GO:0010763)2.39509605
108cellular response to catecholamine stimulus (GO:0071870)2.39362064
109cellular response to monoamine stimulus (GO:0071868)2.39362064
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.38427653
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.37773721
112negative regulation of catenin import into nucleus (GO:0035414)2.37135868
113regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.34895574
114negative regulation of cell size (GO:0045792)2.32579270
115heart morphogenesis (GO:0003007)2.32100169
116cerebellar Purkinje cell layer development (GO:0021680)2.31383862
117cell communication involved in cardiac conduction (GO:0086065)2.30862266
118protein targeting to plasma membrane (GO:0072661)2.29543558
119negative regulation of fatty acid transport (GO:2000192)2.28883114
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.28399843
121protein localization to endosome (GO:0036010)2.27844464
122endodermal cell differentiation (GO:0035987)2.24764841
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.24523657
124nerve growth factor signaling pathway (GO:0038180)2.23715702
125nucleus localization (GO:0051647)2.23415651
126cell-substrate junction assembly (GO:0007044)2.22559535
127regulation of ARF GTPase activity (GO:0032312)2.20738221
128proline transport (GO:0015824)2.20626446
129cytoplasmic mRNA processing body assembly (GO:0033962)2.17528357
130neuromuscular process controlling balance (GO:0050885)2.17504353
131neuromuscular junction development (GO:0007528)2.16418107
132regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.14367575
133cellular sodium ion homeostasis (GO:0006883)2.13179340
134positive regulation of glycogen metabolic process (GO:0070875)2.12666538
135growth hormone secretion (GO:0030252)2.12317538
136heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.12143515
137alanine transport (GO:0032328)2.11927007
138positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.11714162
139cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.11572150
140macroautophagy (GO:0016236)2.11486494
141vocalization behavior (GO:0071625)2.10461445
142regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.10039010
143positive regulation of axon extension (GO:0045773)2.08674527
144cell migration involved in sprouting angiogenesis (GO:0002042)2.07641986
145regulation of clathrin-mediated endocytosis (GO:2000369)2.07534482
146innervation (GO:0060384)2.07283232
147focal adhesion assembly (GO:0048041)2.06777195
148cell-substrate adherens junction assembly (GO:0007045)2.06777195
149camera-type eye morphogenesis (GO:0048593)2.05603176
150regulation of axon extension involved in axon guidance (GO:0048841)2.04100195
151membrane depolarization during action potential (GO:0086010)2.03387512
152cAMP biosynthetic process (GO:0006171)2.03362689
153positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.03328580
154negative regulation of vascular permeability (GO:0043116)2.02429327
155positive regulation of synapse maturation (GO:0090129)2.01717152
156multicellular organismal macromolecule metabolic process (GO:0044259)2.00274213
157mannose metabolic process (GO:0006013)2.00251765
158fibroblast migration (GO:0010761)1.99978475
159collagen metabolic process (GO:0032963)1.99846821
160ovulation cycle (GO:0042698)1.99823364
161negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.99574258
162neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.99393350
163positive regulation of Rap GTPase activity (GO:0032854)1.99042931
164positive regulation of fatty acid beta-oxidation (GO:0032000)1.99015385
165regulation of fatty acid beta-oxidation (GO:0031998)1.98531171
166negative regulation of potassium ion transmembrane transport (GO:1901380)1.97437872
167positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.97221438
168collagen catabolic process (GO:0030574)1.96909308
169coronary vasculature morphogenesis (GO:0060977)1.96688863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.50864149
2DROSHA_22980978_ChIP-Seq_HELA_Human2.46195813
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32228341
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06276817
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04899467
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97512247
7EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96893894
8RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96893894
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.90421622
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89419840
11TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85823073
12KDM2B_26808549_Chip-Seq_K562_Human1.83144915
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.82323776
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81541450
15REST_21632747_ChIP-Seq_MESCs_Mouse1.77228288
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.75617672
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.75332884
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66606223
19DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.66480256
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65728338
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64846481
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63636694
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63549982
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62308892
25CTCF_27219007_Chip-Seq_Bcells_Human1.61593485
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61304989
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.60306551
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60057969
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.56869749
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56410332
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56384098
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.55491411
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55183534
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.54384667
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.52333089
36KDM2B_26808549_Chip-Seq_DND41_Human1.51474628
37WT1_25993318_ChIP-Seq_PODOCYTE_Human1.49947328
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.48818568
39SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48166032
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47988222
41* SMC4_20622854_ChIP-Seq_HELA_Human1.47703981
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.45042673
43RACK7_27058665_Chip-Seq_MCF-7_Human1.45029203
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43369885
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.39960903
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39405325
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38958205
48TET1_21490601_ChIP-Seq_MESCs_Mouse1.38937493
49CLOCK_20551151_ChIP-Seq_293T_Human1.37786282
50* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37410809
51ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37001861
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36988180
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36814655
54CREB1_26743006_Chip-Seq_LNCaP_Human1.36165303
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.34652218
56TP53_16413492_ChIP-PET_HCT116_Human1.34478550
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.34442052
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.33476852
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33424035
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32547361
61AR_21572438_ChIP-Seq_LNCaP_Human1.32436879
62P68_20966046_ChIP-Seq_HELA_Human1.29964198
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29828972
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28886341
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.28717589
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28282341
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28034782
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27188867
69TBX20_22328084_ChIP-Seq_HEART_Mouse1.26503941
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.26503941
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26449684
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24735982
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23941400
74AHR_22903824_ChIP-Seq_MCF-7_Human1.23779411
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23474590
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22715587
77LXR_22292898_ChIP-Seq_THP-1_Human1.20742279
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20118847
79* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19430105
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19151568
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19090331
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18067111
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17975638
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.17862345
85AR_19668381_ChIP-Seq_PC3_Human1.15153258
86* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15043242
87GBX2_23144817_ChIP-Seq_PC3_Human1.14068600
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.13386647
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13071394
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12751191
91* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11137756
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10198333
93ARNT_22903824_ChIP-Seq_MCF-7_Human1.09230868
94DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09085377
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.08775774
96ISL1_27105846_Chip-Seq_CPCs_Mouse1.08659910
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.07768332
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.07380812
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07339596
100TP53_20018659_ChIP-ChIP_R1E_Mouse1.07115545
101* OCT4_19829295_ChIP-Seq_ESCs_Human1.06806164
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05968375
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05128095
104TCF7_22412390_ChIP-Seq_EML_Mouse1.04635704
105ERG_21242973_ChIP-ChIP_JURKAT_Human1.04602976
106ELK3_25401928_ChIP-Seq_HUVEC_Human1.02755298
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01756643
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00059600
109TP63_17297297_ChIP-ChIP_HaCaT_Human0.99590355
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99543453
111SOX2_21211035_ChIP-Seq_LN229_Gbm0.99023141
112RING1B_27294783_Chip-Seq_ESCs_Mouse0.98798303
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.98391415
114CJUN_26792858_Chip-Seq_BT549_Human0.97286065
115VDR_21846776_ChIP-Seq_THP-1_Human0.96484131
116PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96294515
117* TET1_21451524_ChIP-Seq_MESCs_Mouse0.96293313
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95998383
119PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95991471
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95070387
121RXR_22108803_ChIP-Seq_LS180_Human0.94780142
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.94356468
123* TP53_23651856_ChIP-Seq_MEFs_Mouse0.94267758
124SMAD3_21741376_ChIP-Seq_HESCs_Human0.93863291
125* TP63_22573176_ChIP-Seq_HFKS_Human0.92879614
126SMAD4_21741376_ChIP-Seq_HESCs_Human0.91923778
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91727548
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91201224
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.91048148
130GATA1_19941826_ChIP-Seq_K562_Human0.90514309
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90351592
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89483467

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.13126374
2MP0005423_abnormal_somatic_nervous3.61575779
3MP0003880_abnormal_central_pattern3.54993174
4MP0003705_abnormal_hypodermis_morpholog3.52363428
5MP0005275_abnormal_skin_tensile3.24513041
6MP0004859_abnormal_synaptic_plasticity3.23165392
7MP0009780_abnormal_chondrocyte_physiolo2.87263577
8MP0000751_myopathy2.80641709
9MP0005503_abnormal_tendon_morphology2.68952705
10MP0001958_emphysema2.64901764
11MP0003283_abnormal_digestive_organ2.55565710
12MP0000569_abnormal_digit_pigmentation2.51233123
13MP0005623_abnormal_meninges_morphology2.41053405
14MP0002734_abnormal_mechanical_nocicepti2.39048131
15MP0000013_abnormal_adipose_tissue2.37004269
16MP0003879_abnormal_hair_cell2.25215185
17MP0008961_abnormal_basal_metabolism2.17250883
18MP0004272_abnormal_basement_membrane2.15350695
19MP0001348_abnormal_lacrimal_gland2.15221761
20MP0001486_abnormal_startle_reflex2.13666196
21MP0002272_abnormal_nervous_system2.10277315
22MP0005409_darkened_coat_color2.05546984
23MP0002572_abnormal_emotion/affect_behav2.02690641
24MP0002837_dystrophic_cardiac_calcinosis2.02468876
25MP0000003_abnormal_adipose_tissue2.00867469
26MP0003300_gastrointestinal_ulcer1.92435480
27* MP0003045_fibrosis1.91473993
28* MP0003279_aneurysm1.90125670
29MP0002909_abnormal_adrenal_gland1.87754564
30MP0001501_abnormal_sleep_pattern1.82667967
31MP0004858_abnormal_nervous_system1.72886216
32MP0004084_abnormal_cardiac_muscle1.68664273
33MP0001299_abnormal_eye_distance/1.66981837
34MP0004130_abnormal_muscle_cell1.66496309
35MP0003091_abnormal_cell_migration1.66346864
36MP0001502_abnormal_circadian_rhythm1.66202148
37MP0002108_abnormal_muscle_morphology1.65557102
38MP0001968_abnormal_touch/_nociception1.63035098
39MP0004145_abnormal_muscle_electrophysio1.59415589
40MP0003566_abnormal_cell_adhesion1.59322954
41MP0002735_abnormal_chemical_nociception1.57958994
42MP0003635_abnormal_synaptic_transmissio1.54747109
43MP0005670_abnormal_white_adipose1.50818264
44MP0005375_adipose_tissue_phenotype1.50672808
45MP0002822_catalepsy1.46886642
46MP0001970_abnormal_pain_threshold1.44315229
47MP0004087_abnormal_muscle_fiber1.44302649
48MP0002877_abnormal_melanocyte_morpholog1.38364286
49MP0000733_abnormal_muscle_development1.38003696
50MP0002733_abnormal_thermal_nociception1.34881942
51MP0001440_abnormal_grooming_behavior1.32035059
52MP0000920_abnormal_myelination1.31810718
53MP0005257_abnormal_intraocular_pressure1.31760761
54MP0003634_abnormal_glial_cell1.31087905
55MP0000778_abnormal_nervous_system1.30318127
56MP0005076_abnormal_cell_differentiation1.29042354
57MP0004510_myositis1.25307445
58MP0004233_abnormal_muscle_weight1.24622823
59MP0002067_abnormal_sensory_capabilities1.24394107
60MP0002066_abnormal_motor_capabilities/c1.23202107
61MP0010368_abnormal_lymphatic_system1.23095387
62MP0009384_cardiac_valve_regurgitation1.22275158
63MP0002557_abnormal_social/conspecific_i1.22051414
64MP0004036_abnormal_muscle_relaxation1.21414265
65MP0008569_lethality_at_weaning1.21395471
66MP0004215_abnormal_myocardial_fiber1.20175222
67MP0000749_muscle_degeneration1.19091681
68MP0002269_muscular_atrophy1.18882954
69MP0005666_abnormal_adipose_tissue1.18426077
70MP0002882_abnormal_neuron_morphology1.16967871
71* MP0002249_abnormal_larynx_morphology1.15485025
72MP0000579_abnormal_nail_morphology1.15001547
73MP0000955_abnormal_spinal_cord1.12776107
74MP0000747_muscle_weakness1.12606206
75MP0003123_paternal_imprinting1.11994622
76MP0002184_abnormal_innervation1.10862753
77* MP0002896_abnormal_bone_mineralization1.10736234
78MP0000759_abnormal_skeletal_muscle1.10131665
79MP0009046_muscle_twitch1.07660474
80MP0005330_cardiomyopathy1.07369411
81MP0004185_abnormal_adipocyte_glucose1.06828861
82MP0000767_abnormal_smooth_muscle1.06825106
83MP0002089_abnormal_postnatal_growth/wei1.05891718
84MP0003631_nervous_system_phenotype1.03820681
85MP0004270_analgesia1.03115437
86MP0000534_abnormal_ureter_morphology0.99662268
87MP0006138_congestive_heart_failure0.98971068
88* MP0010630_abnormal_cardiac_muscle0.97622131
89* MP0002168_other_aberrant_phenotype0.97487130
90MP0003385_abnormal_body_wall0.97292961
91MP0002063_abnormal_learning/memory/cond0.96956877
92MP0008775_abnormal_heart_ventricle0.96743226
93MP0002234_abnormal_pharynx_morphology0.95352283
94MP0000428_abnormal_craniofacial_morphol0.94901981
95MP0004924_abnormal_behavior0.94106669
96MP0005386_behavior/neurological_phenoty0.94106669
97MP0010234_abnormal_vibrissa_follicle0.93990659
98MP0005620_abnormal_muscle_contractility0.93933821
99MP0001177_atelectasis0.93502351
100MP0005369_muscle_phenotype0.93045723
101MP0004085_abnormal_heartbeat0.92986778
102MP0002295_abnormal_pulmonary_circulatio0.92919421
103MP0002060_abnormal_skin_morphology0.91891489
104MP0003632_abnormal_nervous_system0.91271421
105MP0010352_gastrointestinal_tract_polyps0.90579469
106MP0000750_abnormal_muscle_regeneration0.90468471
107* MP0002152_abnormal_brain_morphology0.90403126
108MP0003115_abnormal_respiratory_system0.87868165
109MP0004885_abnormal_endolymph0.86639011
110MP0000566_synostosis0.86205134
111* MP0005508_abnormal_skeleton_morphology0.84872795
112MP0002106_abnormal_muscle_physiology0.83457273
113MP0006276_abnormal_autonomic_nervous0.83151337
114MP0003172_abnormal_lysosome_physiology0.82425403
115MP0008874_decreased_physiological_sensi0.80489673
116MP0003303_peritoneal_inflammation0.80338199
117MP0002972_abnormal_cardiac_muscle0.79419112
118MP0003137_abnormal_impulse_conducting0.79204963
119MP0005646_abnormal_pituitary_gland0.79143081
120MP0000604_amyloidosis0.78063879
121MP0002064_seizures0.78017319
122MP0005023_abnormal_wound_healing0.76820049
123MP0004811_abnormal_neuron_physiology0.76729118
124MP0009278_abnormal_bone_marrow0.76683065
125MP0009745_abnormal_behavioral_response0.76631448
126MP0005187_abnormal_penis_morphology0.75338741
127MP0003329_amyloid_beta_deposits0.74322088
128MP0000678_abnormal_parathyroid_gland0.74248873
129MP0003122_maternal_imprinting0.73819187
130MP0005167_abnormal_blood-brain_barrier0.73719129
131* MP0002925_abnormal_cardiovascular_devel0.73336755
132MP0006054_spinal_hemorrhage0.72050817
133MP0003690_abnormal_glial_cell0.71781742
134MP0001544_abnormal_cardiovascular_syste0.70602493
135MP0005385_cardiovascular_system_phenoty0.70602493
136MP0002736_abnormal_nociception_after0.70547765
137* MP0002128_abnormal_blood_circulation0.70326488
138MP0001963_abnormal_hearing_physiology0.69939907
139MP0001346_abnormal_lacrimal_gland0.69267922
140MP0001984_abnormal_olfaction0.68297534
141MP0001849_ear_inflammation0.67910838
142MP0004484_altered_response_of0.67849647
143MP0003633_abnormal_nervous_system0.66922594
144MP0000681_abnormal_thyroid_gland0.66143427
145MP0001879_abnormal_lymphatic_vessel0.66032876
146* MP0000266_abnormal_heart_morphology0.65820284
147MP0002229_neurodegeneration0.65227209
148MP0001188_hyperpigmentation0.62001738

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)5.44069317
2Myokymia (HP:0002411)4.53619320
3Protrusio acetabuli (HP:0003179)4.37235499
4Broad metatarsal (HP:0001783)4.17609401
5Premature rupture of membranes (HP:0001788)3.82763360
6Shallow orbits (HP:0000586)3.81948173
7Supranuclear gaze palsy (HP:0000605)3.64205022
8Ankle contracture (HP:0006466)3.62603751
9* Cerebral aneurysm (HP:0004944)3.55698190
10Focal motor seizures (HP:0011153)3.53467134
11Annular pancreas (HP:0001734)3.40861338
12Aortic aneurysm (HP:0004942)3.40834720
13Diplopia (HP:0000651)3.35058301
14Abnormality of binocular vision (HP:0011514)3.35058301
15Bladder diverticulum (HP:0000015)3.29065226
16Aortic dissection (HP:0002647)3.26444359
17Ankle clonus (HP:0011448)3.26153422
18Neurofibrillary tangles (HP:0002185)3.15474205
19Increased connective tissue (HP:0009025)3.05572384
20Dilatation of the ascending aorta (HP:0005111)3.03861892
21Febrile seizures (HP:0002373)2.97667214
22Mitral valve prolapse (HP:0001634)2.95139089
23Epileptic encephalopathy (HP:0200134)2.86573062
24Hyperacusis (HP:0010780)2.81804359
25Increased variability in muscle fiber diameter (HP:0003557)2.68530356
26Type 1 muscle fiber predominance (HP:0003803)2.68286860
27Broad face (HP:0000283)2.66358618
28Cerebral inclusion bodies (HP:0100314)2.62224840
29Torticollis (HP:0000473)2.60838172
30Atonic seizures (HP:0010819)2.60638167
31Atrophic scars (HP:0001075)2.60492998
32Macroorchidism (HP:0000053)2.58539235
33Sleep apnea (HP:0010535)2.58394952
34* Aneurysm (HP:0002617)2.55905712
35Truncal ataxia (HP:0002078)2.54278876
36Mildly elevated creatine phosphokinase (HP:0008180)2.52265071
37Progressive cerebellar ataxia (HP:0002073)2.47549050
38Renovascular hypertension (HP:0100817)2.44669484
39Spastic gait (HP:0002064)2.40425617
40Striae distensae (HP:0001065)2.39219416
41Distal upper limb amyotrophy (HP:0007149)2.38511832
42Upper limb amyotrophy (HP:0009129)2.38511832
43Difficulty running (HP:0009046)2.37651332
44Elfin facies (HP:0004428)2.34289005
45Genu recurvatum (HP:0002816)2.32945185
46* Bowel diverticulosis (HP:0005222)2.32888153
47Dysmetric saccades (HP:0000641)2.29731587
48Postural instability (HP:0002172)2.28374223
49Flat cornea (HP:0007720)2.26381138
50Fragile skin (HP:0001030)2.25437396
51Impaired smooth pursuit (HP:0007772)2.22911661
52Short 4th metacarpal (HP:0010044)2.21795198
53Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.21795198
54Abnormality of skeletal muscle fiber size (HP:0012084)2.20732890
55Hemiplegia (HP:0002301)2.19997138
56Neoplasm of the heart (HP:0100544)2.16892865
57Long toe (HP:0010511)2.16006998
58Vascular tortuosity (HP:0004948)2.15429046
59Urinary bladder sphincter dysfunction (HP:0002839)2.14340851
60Hyporeflexia of lower limbs (HP:0002600)2.13773413
61Insomnia (HP:0100785)2.11245532
62Cervical subluxation (HP:0003308)2.09352597
63Spinal canal stenosis (HP:0003416)2.08323715
64Dysmetria (HP:0001310)2.07985684
65Depression (HP:0000716)2.07537640
66Turricephaly (HP:0000262)2.06779355
67Enlarged penis (HP:0000040)2.06464685
68Stridor (HP:0010307)2.06335136
69Spinal rigidity (HP:0003306)2.06178228
70Soft skin (HP:0000977)2.05612628
71Action tremor (HP:0002345)2.04902092
72Overgrowth (HP:0001548)2.04834445
73Lower limb amyotrophy (HP:0007210)2.03918641
74Arterial tortuosity (HP:0005116)2.03168873
75Wrist flexion contracture (HP:0001239)2.02271916
76Neuronal loss in central nervous system (HP:0002529)2.00712769
77Abnormality of the 4th metacarpal (HP:0010012)1.97809752
78Aplasia involving bones of the extremities (HP:0009825)1.97729267
79Aplasia involving bones of the upper limbs (HP:0009823)1.97729267
80Aplasia of the phalanges of the hand (HP:0009802)1.97729267
81Stereotypic behavior (HP:0000733)1.97679809
82Thin bony cortex (HP:0002753)1.97079059
83Scapular winging (HP:0003691)1.96362858
84Renal duplication (HP:0000075)1.95766183
85Follicular hyperkeratosis (HP:0007502)1.95473272
86Sudden death (HP:0001699)1.95264076
87Abnormal eating behavior (HP:0100738)1.95037842
88Bundle branch block (HP:0011710)1.94907682
89Peritonitis (HP:0002586)1.94694354
90Broad ribs (HP:0000885)1.93995877
91Hand muscle atrophy (HP:0009130)1.93280081
92Distal lower limb amyotrophy (HP:0008944)1.92549440
93Slender build (HP:0001533)1.92256123
94Narrow palate (HP:0000189)1.92218026
95Mild short stature (HP:0003502)1.91396069
96Hyperextensible skin (HP:0000974)1.91066064
97Overriding aorta (HP:0002623)1.90367638
98Akinesia (HP:0002304)1.90090427
99Hypoventilation (HP:0002791)1.89889043
100Joint laxity (HP:0001388)1.89767597
101Pointed chin (HP:0000307)1.89072849
102Lymphangioma (HP:0100764)1.88828370
103Focal seizures (HP:0007359)1.87958625
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87191402
105Deviation of the hallux (HP:0010051)1.87130036
106Generalized tonic-clonic seizures (HP:0002069)1.87066589
107Abnormality of the lower motor neuron (HP:0002366)1.85683003
108Tetraplegia (HP:0002445)1.85232523
109Focal dystonia (HP:0004373)1.85064814
110Buphthalmos (HP:0000557)1.82802619
111Difficulty climbing stairs (HP:0003551)1.82538699
112Abnormality of ocular smooth pursuit (HP:0000617)1.82218954
113Hallux valgus (HP:0001822)1.82102495
114Rapidly progressive (HP:0003678)1.81623286
115Craniofacial dystonia (HP:0012179)1.81504151
116Abnormal atrioventricular conduction (HP:0005150)1.80941400
117Blue sclerae (HP:0000592)1.79324030
118Round ear (HP:0100830)1.78444644
119Mitral regurgitation (HP:0001653)1.77359434
120Hypoplastic ischia (HP:0003175)1.77179482
121Precocious puberty (HP:0000826)1.77024406
122Disproportionate tall stature (HP:0001519)1.77000891
123Camptodactyly of toe (HP:0001836)1.76885625
124Hammertoe (HP:0001765)1.75515926
125Wormian bones (HP:0002645)1.75196300
126Muscle fiber splitting (HP:0003555)1.74271302
127Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71874502
128Heart block (HP:0012722)1.71841110
129Lower limb asymmetry (HP:0100559)1.71752940
130Genetic anticipation (HP:0003743)1.71735522
131Lower limb muscle weakness (HP:0007340)1.69813668
132Absence seizures (HP:0002121)1.69576562
133Papilledema (HP:0001085)1.69143182
134EMG: neuropathic changes (HP:0003445)1.68043969
135Bronchomalacia (HP:0002780)1.66458010
136Clonus (HP:0002169)1.65683021
137Foot dorsiflexor weakness (HP:0009027)1.65237793
138Intention tremor (HP:0002080)1.64124842
139Abnormality of the fingertips (HP:0001211)1.63926874
140Scanning speech (HP:0002168)1.62920413
141Absent frontal sinuses (HP:0002688)1.62515514
142Ulnar bowing (HP:0003031)1.62389106
143Vertebral arch anomaly (HP:0008438)1.61141907
144Prolonged QT interval (HP:0001657)1.59164883
145Right ventricular cardiomyopathy (HP:0011663)1.58691267
146Abnormality of the ischium (HP:0003174)1.56144888
147Atrial fibrillation (HP:0005110)1.54799829
148Radial bowing (HP:0002986)1.54426334
149Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.53718292
150Increased density of long bones (HP:0006392)1.53213541
151Visual hallucinations (HP:0002367)1.52404260
152Aortic regurgitation (HP:0001659)1.52344648
153Resting tremor (HP:0002322)1.52304564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.72551228
2RIPK13.24064292
3TTN3.13950658
4PDGFRA2.71047328
5SIK12.35853214
6PRPF4B2.35674495
7PKN22.26610271
8DDR22.24950506
9CAMK1G2.15181842
10PRKD32.10112883
11CAMK1D2.08474707
12UHMK11.99975375
13LATS11.91988067
14DMPK1.77150255
15NTRK31.74636643
16LMTK21.67453127
17STK381.58992139
18PTK61.57378802
19CAMKK11.55254001
20EEF2K1.51610541
21PAK61.47726046
22ERN11.46000545
23MAP3K91.39907520
24FGFR21.35184352
25NTRK11.35157289
26TYRO31.32439251
27RET1.29962859
28PDGFRB1.24211949
29CDK121.22736000
30MAP3K71.22654490
31INSRR1.19728000
32CDC42BPA1.19486652
33TGFBR21.18023560
34ICK1.16706665
35SIK21.15378145
36NTRK21.11536223
37MAPK121.11097284
38JAK11.11044654
39WNK11.11006992
40MTOR1.10414458
41MARK21.10198115
42PTK21.06848467
43CAMKK21.05215894
44DAPK21.04819341
45SMG11.04014138
46KSR21.04008574
47LATS21.01999215
48TAOK11.01902468
49PRKD21.01514381
50PAK31.00424070
51FGFR41.00110814
52BMX0.99827474
53FER0.98947200
54FGFR30.98170854
55MAP3K20.96603174
56SGK30.96546927
57* PRKCH0.96303137
58PHKG20.94560123
59PHKG10.94560123
60PAK20.93492645
61MAP3K100.92182644
62TNK20.89651334
63EPHA40.88231993
64CAMK2B0.87051262
65PRKD10.87006199
66NEK60.81198551
67PTK2B0.80821082
68ARAF0.80568769
69ALK0.80529876
70EPHB10.78461806
71FGFR10.77252579
72MAP3K60.75995130
73CDK150.73535700
74MAPK100.72969231
75SCYL20.72405535
76MAP3K40.71757312
77CAMK40.71216892
78CAMK2G0.70106486
79ROCK10.69647857
80GRK50.68817659
81EPHA30.67661089
82CDK11A0.67290377
83HIPK20.66939695
84CDK180.66050887
85STK110.65410001
86CDK50.64722395
87MINK10.64711823
88DYRK1A0.61210183
89EPHB20.61142417
90CAMK10.58777383
91TESK10.58569022
92RPS6KA20.58329829
93SGK20.58131846
94PKN10.55379012
95MAP3K130.53856117
96MAPK150.53842755
97PRKAA10.53764722
98TIE10.53603819
99MAP2K60.52545152
100CASK0.51942070
101PDPK10.51086254
102DAPK10.50846255
103MAPK70.49824118
104CDK140.48953098
105SGK10.48160388
106RPS6KC10.48012382
107RPS6KL10.48012382
108MAP3K10.46067237
109PDK10.45639250
110PRKAA20.45251362
111MAPK110.43996430
112SGK4940.43694788
113SGK2230.43694788
114* SRC0.43564954
115CAMK2A0.43533708
116RPS6KA30.42704317
117MARK10.42376963
118KSR10.42253234
119FYN0.42148556
120HCK0.41615451
121JAK20.41018137
122FRK0.39307804
123INSR0.38116612
124ERBB20.36542922
125LRRK20.34765708
126ROCK20.34760318
127MAPK80.34493261
128DYRK1B0.33422331

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054141.79967367
2Type II diabetes mellitus_Homo sapiens_hsa049301.66941512
3ECM-receptor interaction_Homo sapiens_hsa045121.60990203
4Insulin secretion_Homo sapiens_hsa049111.58933911
5Circadian entrainment_Homo sapiens_hsa047131.57593964
6Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57571675
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56229523
8Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.51143231
9Focal adhesion_Homo sapiens_hsa045101.50908794
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47552743
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44723747
12Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40483179
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38301965
14Salivary secretion_Homo sapiens_hsa049701.33764428
15Gastric acid secretion_Homo sapiens_hsa049711.32064742
16Long-term potentiation_Homo sapiens_hsa047201.31709121
17Renin secretion_Homo sapiens_hsa049241.28566850
18Nitrogen metabolism_Homo sapiens_hsa009101.28122241
19Olfactory transduction_Homo sapiens_hsa047401.26946290
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26902228
21Glutamatergic synapse_Homo sapiens_hsa047241.24292373
22Oxytocin signaling pathway_Homo sapiens_hsa049211.22980798
23Morphine addiction_Homo sapiens_hsa050321.22105623
24GABAergic synapse_Homo sapiens_hsa047271.21629060
25Cholinergic synapse_Homo sapiens_hsa047251.20286081
26cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20267743
27Estrogen signaling pathway_Homo sapiens_hsa049151.20259597
28Proteoglycans in cancer_Homo sapiens_hsa052051.20132635
29mTOR signaling pathway_Homo sapiens_hsa041501.20033620
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19186484
31Glioma_Homo sapiens_hsa052141.18839120
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17143581
33GnRH signaling pathway_Homo sapiens_hsa049121.16690441
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16262736
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15463703
36Dorso-ventral axis formation_Homo sapiens_hsa043201.13974367
37cAMP signaling pathway_Homo sapiens_hsa040241.09706279
38Protein digestion and absorption_Homo sapiens_hsa049741.09332329
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07915922
40Amoebiasis_Homo sapiens_hsa051461.06115452
41Amphetamine addiction_Homo sapiens_hsa050311.05377430
42Gap junction_Homo sapiens_hsa045401.04010508
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.03215216
44Lysine degradation_Homo sapiens_hsa003101.02739652
45Insulin resistance_Homo sapiens_hsa049311.01365897
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01001131
47Cocaine addiction_Homo sapiens_hsa050301.00757344
48Dopaminergic synapse_Homo sapiens_hsa047281.00498334
49Synaptic vesicle cycle_Homo sapiens_hsa047211.00294145
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.00114119
51Chronic myeloid leukemia_Homo sapiens_hsa052201.00053048
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.99930259
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98421168
54Prion diseases_Homo sapiens_hsa050200.95474728
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93925679
56Calcium signaling pathway_Homo sapiens_hsa040200.93622367
57Nicotine addiction_Homo sapiens_hsa050330.93157659
58Melanogenesis_Homo sapiens_hsa049160.91997178
59Adherens junction_Homo sapiens_hsa045200.91196485
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.90771963
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88078524
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.87258348
63Endometrial cancer_Homo sapiens_hsa052130.87148941
64Insulin signaling pathway_Homo sapiens_hsa049100.86743443
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86589816
66Taste transduction_Homo sapiens_hsa047420.84443164
67Platelet activation_Homo sapiens_hsa046110.84313547
68Glucagon signaling pathway_Homo sapiens_hsa049220.83734688
69Thyroid hormone synthesis_Homo sapiens_hsa049180.83161482
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82996133
71Pancreatic secretion_Homo sapiens_hsa049720.82661584
72Rap1 signaling pathway_Homo sapiens_hsa040150.82278595
73Axon guidance_Homo sapiens_hsa043600.80928847
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80655052
75Vitamin B6 metabolism_Homo sapiens_hsa007500.80641123
76Long-term depression_Homo sapiens_hsa047300.79231191
77ErbB signaling pathway_Homo sapiens_hsa040120.77240555
78AMPK signaling pathway_Homo sapiens_hsa041520.75988577
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75360381
80VEGF signaling pathway_Homo sapiens_hsa043700.74259534
81MAPK signaling pathway_Homo sapiens_hsa040100.73591339
82Serotonergic synapse_Homo sapiens_hsa047260.73316472
83Fatty acid biosynthesis_Homo sapiens_hsa000610.72542214
84Renal cell carcinoma_Homo sapiens_hsa052110.72048173
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.71610282
86Non-small cell lung cancer_Homo sapiens_hsa052230.71609345
87Small cell lung cancer_Homo sapiens_hsa052220.71091159
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70954679
89Bile secretion_Homo sapiens_hsa049760.70207181
90Inositol phosphate metabolism_Homo sapiens_hsa005620.70024222
91Choline metabolism in cancer_Homo sapiens_hsa052310.69800359
92Pancreatic cancer_Homo sapiens_hsa052120.67979111
93Basal cell carcinoma_Homo sapiens_hsa052170.64746942
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62516774
95Notch signaling pathway_Homo sapiens_hsa043300.60902969
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60801154
97Endocytosis_Homo sapiens_hsa041440.60266295
98Ovarian steroidogenesis_Homo sapiens_hsa049130.58141893
99Hippo signaling pathway_Homo sapiens_hsa043900.58112306
100Circadian rhythm_Homo sapiens_hsa047100.58111583
101MicroRNAs in cancer_Homo sapiens_hsa052060.57439993
102Ras signaling pathway_Homo sapiens_hsa040140.56851174
103Prolactin signaling pathway_Homo sapiens_hsa049170.56422392
104Viral myocarditis_Homo sapiens_hsa054160.55312139
105Colorectal cancer_Homo sapiens_hsa052100.53840392
106Bladder cancer_Homo sapiens_hsa052190.53618150
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.53246876
108Tight junction_Homo sapiens_hsa045300.53229387
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52192784
110Vibrio cholerae infection_Homo sapiens_hsa051100.52176820
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50820136
112HIF-1 signaling pathway_Homo sapiens_hsa040660.48304503
113ABC transporters_Homo sapiens_hsa020100.47907718
114Oocyte meiosis_Homo sapiens_hsa041140.45942979
115Wnt signaling pathway_Homo sapiens_hsa043100.44909717
116Acute myeloid leukemia_Homo sapiens_hsa052210.44425413

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