PKD1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.41802406
2intestinal epithelial cell development (GO:0060576)5.09654013
3behavioral response to nicotine (GO:0035095)4.95260848
4mitotic metaphase plate congression (GO:0007080)4.84420399
5rRNA modification (GO:0000154)4.57134800
6formation of translation preinitiation complex (GO:0001731)4.51413643
7DNA replication checkpoint (GO:0000076)4.33572831
8fucose catabolic process (GO:0019317)4.32869673
9L-fucose metabolic process (GO:0042354)4.32869673
10L-fucose catabolic process (GO:0042355)4.32869673
11intestinal cholesterol absorption (GO:0030299)4.22204289
12tryptophan catabolic process (GO:0006569)4.15550765
13indole-containing compound catabolic process (GO:0042436)4.15550765
14indolalkylamine catabolic process (GO:0046218)4.15550765
15ribosome biogenesis (GO:0042254)4.12085569
16protein localization to kinetochore (GO:0034501)4.09753129
17indolalkylamine metabolic process (GO:0006586)4.06096135
18regulation of translation in response to stress (GO:0043555)4.05326703
19kynurenine metabolic process (GO:0070189)3.98662085
20purine nucleobase biosynthetic process (GO:0009113)3.92831549
21GDP-mannose metabolic process (GO:0019673)3.90927874
22rRNA methylation (GO:0031167)3.88931310
23folic acid metabolic process (GO:0046655)3.87748747
24proline biosynthetic process (GO:0006561)3.75708355
25metaphase plate congression (GO:0051310)3.74874569
26nucleobase biosynthetic process (GO:0046112)3.69068976
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69049642
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64824414
29regulation of nuclear cell cycle DNA replication (GO:0033262)3.62872549
30cellular ketone body metabolic process (GO:0046950)3.59330000
31tryptophan metabolic process (GO:0006568)3.57954476
32detection of light stimulus involved in sensory perception (GO:0050962)3.56603027
33detection of light stimulus involved in visual perception (GO:0050908)3.56603027
34mitotic sister chromatid segregation (GO:0000070)3.54151139
35ribosome assembly (GO:0042255)3.52459835
36protein localization to chromosome, centromeric region (GO:0071459)3.52220879
37ketone body metabolic process (GO:1902224)3.43446466
38folic acid transport (GO:0015884)3.41114102
39regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38777335
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34410388
41digestion (GO:0007586)3.32854899
42ribonucleoprotein complex biogenesis (GO:0022613)3.31185887
43regulation of double-strand break repair via homologous recombination (GO:0010569)3.29747426
44DNA replication initiation (GO:0006270)3.28425079
45axoneme assembly (GO:0035082)3.27471119
46regulation of spindle organization (GO:0090224)3.27293055
47response to pheromone (GO:0019236)3.26683904
48piRNA metabolic process (GO:0034587)3.25208880
49proteasome assembly (GO:0043248)3.21912147
50protein K6-linked ubiquitination (GO:0085020)3.21320842
51reflex (GO:0060004)3.21195657
52sulfation (GO:0051923)3.20604486
53parturition (GO:0007567)3.19973737
54exocrine pancreas development (GO:0031017)3.18176570
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15506585
56rRNA processing (GO:0006364)3.14001193
57transcription from RNA polymerase I promoter (GO:0006360)3.13274681
58replication fork processing (GO:0031297)3.11477043
59indole-containing compound metabolic process (GO:0042430)3.10426706
60pseudouridine synthesis (GO:0001522)3.08968853
61glycine metabolic process (GO:0006544)3.08042663
62DNA replication-dependent nucleosome organization (GO:0034723)3.04269878
63DNA replication-dependent nucleosome assembly (GO:0006335)3.04269878
64termination of RNA polymerase III transcription (GO:0006386)3.03524654
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.03524654
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03411882
67establishment of chromosome localization (GO:0051303)3.03268335
68cullin deneddylation (GO:0010388)3.03162314
69rRNA metabolic process (GO:0016072)3.02985945
70regulation of hippo signaling (GO:0035330)3.02889475
71cobalamin metabolic process (GO:0009235)3.02359434
72mitotic nuclear envelope disassembly (GO:0007077)3.02244965
73cellular biogenic amine catabolic process (GO:0042402)2.98644702
74amine catabolic process (GO:0009310)2.98644702
75histone H4-K12 acetylation (GO:0043983)2.97981744
76transcription from mitochondrial promoter (GO:0006390)2.97277418
77RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.97234150
78G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97197380
79behavioral response to ethanol (GO:0048149)2.97128536
80photoreceptor cell maintenance (GO:0045494)2.96824984
81protein retention in ER lumen (GO:0006621)2.96492215
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.96010341
83kinetochore assembly (GO:0051382)2.93596661
84positive regulation of chromosome segregation (GO:0051984)2.93353614
85maturation of SSU-rRNA (GO:0030490)2.93274728
86platelet dense granule organization (GO:0060155)2.89388849
87protein deneddylation (GO:0000338)2.89357675
88neural tube formation (GO:0001841)2.88228741
89retinal cone cell development (GO:0046549)2.88166344
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.87670903
91signal peptide processing (GO:0006465)2.86958859
92auditory receptor cell stereocilium organization (GO:0060088)2.86356448
93epithelial cilium movement (GO:0003351)2.85207951
94negative regulation of mast cell activation (GO:0033004)2.84075152
95respiratory chain complex IV assembly (GO:0008535)2.83243341
96cilium morphogenesis (GO:0060271)2.83200998
97negative regulation of translational initiation (GO:0045947)2.82656360
98protein polyglutamylation (GO:0018095)2.82208609
99termination of RNA polymerase I transcription (GO:0006363)2.81452422
100maturation of 5.8S rRNA (GO:0000460)2.80166711
101rRNA transcription (GO:0009303)2.80156275
102nonmotile primary cilium assembly (GO:0035058)2.79964481
103gamma-aminobutyric acid transport (GO:0015812)2.79743771
104neuronal action potential (GO:0019228)2.79411188
105transcription elongation from RNA polymerase I promoter (GO:0006362)2.79121176
106nuclear envelope disassembly (GO:0051081)2.78879547
107membrane disassembly (GO:0030397)2.78879547
108water-soluble vitamin biosynthetic process (GO:0042364)2.78739689
109negative regulation of chromosome segregation (GO:0051985)2.78027342
110regulation of mitotic spindle organization (GO:0060236)2.77837859
111regulation of spindle checkpoint (GO:0090231)2.76863631
112spindle checkpoint (GO:0031577)2.76728136
113attachment of spindle microtubules to kinetochore (GO:0008608)2.75941538
114sulfur amino acid biosynthetic process (GO:0000097)2.75446255
115cornea development in camera-type eye (GO:0061303)2.75340502
116DNA strand elongation involved in DNA replication (GO:0006271)2.74875988
117mannosylation (GO:0097502)2.74526959
118sister chromatid segregation (GO:0000819)2.73853505
119preassembly of GPI anchor in ER membrane (GO:0016254)2.73707932
120regulation of telomere maintenance via telomerase (GO:0032210)2.73010673
121amino acid salvage (GO:0043102)2.72020337
122L-methionine salvage (GO:0071267)2.72020337
123L-methionine biosynthetic process (GO:0071265)2.72020337
124nephron tubule morphogenesis (GO:0072078)2.71358769
125nephron epithelium morphogenesis (GO:0072088)2.71358769
126meiotic chromosome segregation (GO:0045132)2.71009649
127dopamine transport (GO:0015872)2.70694781
128primary amino compound metabolic process (GO:1901160)2.70356666
129inner ear receptor stereocilium organization (GO:0060122)2.70223430
130telomere maintenance via semi-conservative replication (GO:0032201)2.69391989
131DNA damage response, signal transduction resulting in transcription (GO:0042772)2.69014704
132regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68564910
133regulation of action potential (GO:0098900)2.67172699
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.66414416
135somatic hypermutation of immunoglobulin genes (GO:0016446)2.66414416
136regulation of chromosome segregation (GO:0051983)2.65799174
137pre-miRNA processing (GO:0031054)2.65638002
138NAD biosynthetic process (GO:0009435)2.64539700
139mitotic G1 DNA damage checkpoint (GO:0031571)2.64467979
140protein complex biogenesis (GO:0070271)2.64295002
141regulation of neurotransmitter uptake (GO:0051580)2.63895482
142negative regulation of telomere maintenance (GO:0032205)2.63290289
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63191850
144mitochondrial respiratory chain complex I assembly (GO:0032981)2.62970560
145NADH dehydrogenase complex assembly (GO:0010257)2.62970560
146mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62970560
147protein localization to cilium (GO:0061512)2.62962322
148protein-cofactor linkage (GO:0018065)2.62654072
149spindle assembly (GO:0051225)2.62576197
150positive regulation of fatty acid transport (GO:2000193)2.61859743
151spindle assembly checkpoint (GO:0071173)2.61668995
152DNA strand elongation (GO:0022616)2.60474220
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60420176
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.59876913
155serotonin metabolic process (GO:0042428)2.59610019
156DNA methylation involved in gamete generation (GO:0043046)2.58699889
157aromatic amino acid family catabolic process (GO:0009074)2.58464116
158negative regulation of mitotic sister chromatid separation (GO:2000816)2.56709781
159negative regulation of mitotic sister chromatid segregation (GO:0033048)2.56709781
160negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.56709781
161negative regulation of sister chromatid segregation (GO:0033046)2.56709781
162regulation of cilium movement (GO:0003352)2.56282407
163regulation of hexokinase activity (GO:1903299)2.56225961
164regulation of glucokinase activity (GO:0033131)2.56225961
165inner cell mass cell proliferation (GO:0001833)2.56122574
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.55640984
167rhodopsin mediated signaling pathway (GO:0016056)2.55056304
168aspartate family amino acid biosynthetic process (GO:0009067)2.54208234
169mitotic spindle assembly checkpoint (GO:0007094)2.54105941
170cAMP catabolic process (GO:0006198)2.53766666
171benzene-containing compound metabolic process (GO:0042537)2.53655394
172cilium or flagellum-dependent cell motility (GO:0001539)2.53439605
173protein K11-linked deubiquitination (GO:0035871)2.53055237
174ovulation cycle (GO:0042698)2.52974125
175reciprocal DNA recombination (GO:0035825)2.50922080
176reciprocal meiotic recombination (GO:0007131)2.50922080
177multicellular organism reproduction (GO:0032504)2.49418629
178cilium organization (GO:0044782)2.49056405
179photoreceptor cell development (GO:0042461)2.48957549
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.47606832
181S-adenosylmethionine metabolic process (GO:0046500)2.47582972
182kidney morphogenesis (GO:0060993)2.47338584
183cytochrome complex assembly (GO:0017004)2.45643611
184adaptation of signaling pathway (GO:0023058)2.44394232
185rRNA catabolic process (GO:0016075)2.43499618
186oxidative demethylation (GO:0070989)2.43137471
187cilium movement (GO:0003341)2.41252690
188positive regulation of meiosis (GO:0045836)2.40761594
189cilium assembly (GO:0042384)2.39507195
190regulation of posttranscriptional gene silencing (GO:0060147)2.39069655
191regulation of gene silencing by miRNA (GO:0060964)2.39069655
192regulation of gene silencing by RNA (GO:0060966)2.39069655
193negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38656237
194mitochondrial respiratory chain complex assembly (GO:0033108)2.38585444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.50143177
2ZNF274_21170338_ChIP-Seq_K562_Hela3.68323703
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.55060185
4VDR_22108803_ChIP-Seq_LS180_Human3.54259729
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.35694228
6GBX2_23144817_ChIP-Seq_PC3_Human3.22997561
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.20856469
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83219714
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78151913
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76032898
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72839588
12EZH2_22144423_ChIP-Seq_EOC_Human2.65407071
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.64606622
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64516878
15IGF1R_20145208_ChIP-Seq_DFB_Human2.63653446
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63558200
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61523462
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58122244
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.56467362
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51371757
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51371757
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51371757
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.40512379
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35826639
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33524076
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.32940606
27CREB1_15753290_ChIP-ChIP_HEK293T_Human2.31466461
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.31354111
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.30760536
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.30671462
31NANOG_18555785_ChIP-Seq_MESCs_Mouse2.27507036
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.25241539
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23585744
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.16217945
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.14959962
36TAF15_26573619_Chip-Seq_HEK293_Human2.14793506
37P300_19829295_ChIP-Seq_ESCs_Human2.07818673
38STAT3_1855785_ChIP-Seq_MESCs_Mouse2.02711418
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.02706496
40YY1_21170310_ChIP-Seq_MESCs_Mouse2.01203616
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97663500
42FUS_26573619_Chip-Seq_HEK293_Human1.96132650
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94270005
44EWS_26573619_Chip-Seq_HEK293_Human1.92395379
45VDR_23849224_ChIP-Seq_CD4+_Human1.89246423
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87126897
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86640951
48ER_23166858_ChIP-Seq_MCF-7_Human1.86269567
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85664615
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83060559
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82760285
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82454280
53BCAT_22108803_ChIP-Seq_LS180_Human1.76656479
54NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.75135925
55GABP_19822575_ChIP-Seq_HepG2_Human1.72696101
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72019684
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69719299
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.67766233
59XRN2_22483619_ChIP-Seq_HELA_Human1.65454909
60DCP1A_22483619_ChIP-Seq_HELA_Human1.64623126
61* STAT3_23295773_ChIP-Seq_U87_Human1.64320401
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63780905
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63575039
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60679514
65SMAD4_21799915_ChIP-Seq_A2780_Human1.60435560
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.60376406
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58605693
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57712549
69TCF4_23295773_ChIP-Seq_U87_Human1.56347487
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56016131
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55468676
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53447494
73CBP_20019798_ChIP-Seq_JUKART_Human1.53447494
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53155683
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51833627
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51773198
77AR_25329375_ChIP-Seq_VCAP_Human1.50084556
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47543076
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47484712
80TP53_22573176_ChIP-Seq_HFKS_Human1.47326851
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46273495
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44191618
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42546036
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42082023
85FOXP3_21729870_ChIP-Seq_TREG_Human1.41640700
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40573980
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40464762
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40392084
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39975987
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.39603463
91NANOG_19829295_ChIP-Seq_ESCs_Human1.38942185
92SOX2_19829295_ChIP-Seq_ESCs_Human1.38942185
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38912936
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38678522
95KDM5A_27292631_Chip-Seq_BREAST_Human1.37662554
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37366987
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.35093702
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34101570
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.33902123
100* TCF4_22108803_ChIP-Seq_LS180_Human1.33795254
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.32482936
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31647125
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.31480971
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30570546
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.30184582
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30184582
107IRF8_21731497_ChIP-ChIP_J774_Mouse1.29631163
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29187501
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29187501
110RUNX2_22187159_ChIP-Seq_PCA_Human1.28283341
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27569732
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25249219
113NOTCH1_21737748_ChIP-Seq_TLL_Human1.24890262
114TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23180604
115REST_21632747_ChIP-Seq_MESCs_Mouse1.22894256
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22154187
117TTF2_22483619_ChIP-Seq_HELA_Human1.21769794
118GATA3_21878914_ChIP-Seq_MCF-7_Human1.21341422
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21101423
120BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20887475
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20592676
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.20051648
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.20041464
124* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18931140
125OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18294066
126E2F1_21310950_ChIP-Seq_MCF-7_Human1.17942195
127FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17861078
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17445178
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17072107
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16929863
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16673145
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15322673
133AR_21572438_ChIP-Seq_LNCaP_Human1.14970187
134TFEB_21752829_ChIP-Seq_HELA_Human1.14193036
135EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13245117
136AR_20517297_ChIP-Seq_VCAP_Human1.13223157
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.13031340
138MYC_22102868_ChIP-Seq_BL_Human1.12986128
139CBX2_27304074_Chip-Seq_ESCs_Mouse1.12969277
140PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12307068
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11519132
142AR_21909140_ChIP-Seq_LNCAP_Human1.10023532
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09860258
144CIITA_25753668_ChIP-Seq_RAJI_Human1.09813509
145NANOG_18555785_Chip-Seq_ESCs_Mouse1.09428501
146* CDX2_22108803_ChIP-Seq_LS180_Human1.09355015
147CRX_20693478_ChIP-Seq_RETINA_Mouse1.09299302
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08944181
149RNF2_27304074_Chip-Seq_NSC_Mouse1.07788768
150NCOR_22424771_ChIP-Seq_293T_Human1.07236842
151NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06958962
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06707187
153SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06170920
154SRF_21415370_ChIP-Seq_HL-1_Mouse1.05923206
155HOXB7_26014856_ChIP-Seq_BT474_Human1.05769351
156P53_22387025_ChIP-Seq_ESCs_Mouse1.05739157
157EGR1_19374776_ChIP-ChIP_THP-1_Human1.04983304
158MYC_18940864_ChIP-ChIP_HL60_Human1.04817174
159TP53_16413492_ChIP-PET_HCT116_Human1.04109007
160KAP1_27257070_Chip-Seq_ESCs_Mouse1.03985944
161MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03922203
162OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03597545
163POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03348181
164SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03243469
165IRF1_19129219_ChIP-ChIP_H3396_Human1.02833503
166TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01910980
167TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01697413
168* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00977646
169ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00742199
170TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00422658
171SPI1_23547873_ChIP-Seq_NB4_Human1.00098050
172SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99869342
173STAT3_18555785_Chip-Seq_ESCs_Mouse0.99518928
174FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99484410
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98256491
176BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97751859
177YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97345481
178NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97055031
179ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96834592
180NANOG_21062744_ChIP-ChIP_HESCs_Human0.95842460
181TP63_19390658_ChIP-ChIP_HaCaT_Human0.94858573
182PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93749554
183E2F1_18555785_Chip-Seq_ESCs_Mouse0.93325161
184SOX2_18692474_ChIP-Seq_MESCs_Mouse0.93146532
185* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92713564
186ELK1_19687146_ChIP-ChIP_HELA_Human0.92452159
187OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92422199
188NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92341714
189SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92172626
190SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92165951
191ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91247808
192NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90733921
193KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89738483
194SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89183761
195SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88264306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.20654771
2MP0008057_abnormal_DNA_replication4.98337254
3MP0003111_abnormal_nucleus_morphology4.13815579
4MP0004957_abnormal_blastocyst_morpholog3.99644751
5MP0003077_abnormal_cell_cycle3.22688186
6MP0003195_calcinosis2.97745470
7MP0010094_abnormal_chromosome_stability2.96844704
8MP0005083_abnormal_biliary_tract2.88824047
9MP0003646_muscle_fatigue2.86160119
10MP0001666_abnormal_nutrient_absorption2.75807174
11MP0005551_abnormal_eye_electrophysiolog2.67259680
12MP0000569_abnormal_digit_pigmentation2.62661714
13MP0008058_abnormal_DNA_repair2.45193254
14MP0002876_abnormal_thyroid_physiology2.41410976
15MP0002102_abnormal_ear_morphology2.40455403
16MP0003123_paternal_imprinting2.33953306
17MP0005220_abnormal_exocrine_pancreas2.26864530
18MP0002837_dystrophic_cardiac_calcinosis2.26595743
19MP0001968_abnormal_touch/_nociception2.26228353
20MP0005646_abnormal_pituitary_gland2.26015875
21MP0008007_abnormal_cellular_replicative2.25456656
22MP0001501_abnormal_sleep_pattern2.24741365
23MP0003011_delayed_dark_adaptation2.22842760
24MP0003786_premature_aging2.22546741
25MP0009046_muscle_twitch2.10387491
26MP0003718_maternal_effect2.09562812
27MP0008260_abnormal_autophagy2.09238443
28MP0002277_abnormal_respiratory_mucosa2.07978507
29MP0000490_abnormal_crypts_of2.07690640
30MP0002638_abnormal_pupillary_reflex2.07503532
31MP0009333_abnormal_splenocyte_physiolog2.06972961
32MP0005058_abnormal_lysosome_morphology2.03184542
33MP0010352_gastrointestinal_tract_polyps1.99870571
34MP0003136_yellow_coat_color1.99157970
35MP0000372_irregular_coat_pigmentation1.98194713
36MP0002736_abnormal_nociception_after1.93463868
37MP0004142_abnormal_muscle_tone1.92694906
38MP0008932_abnormal_embryonic_tissue1.91466778
39MP0004043_abnormal_pH_regulation1.88630056
40MP0008872_abnormal_physiological_respon1.87808577
41MP0008875_abnormal_xenobiotic_pharmacok1.82883545
42MP0006072_abnormal_retinal_apoptosis1.82224731
43MP0010307_abnormal_tumor_latency1.81548399
44MP0005253_abnormal_eye_physiology1.80196933
45MP0009745_abnormal_behavioral_response1.79234577
46MP0002653_abnormal_ependyma_morphology1.78865777
47MP0004264_abnormal_extraembryonic_tissu1.78621833
48MP0006276_abnormal_autonomic_nervous1.71513200
49MP0003787_abnormal_imprinting1.71356974
50MP0003172_abnormal_lysosome_physiology1.67731452
51MP0000350_abnormal_cell_proliferation1.66777991
52MP0001730_embryonic_growth_arrest1.66282857
53MP0009278_abnormal_bone_marrow1.61563413
54MP0000427_abnormal_hair_cycle1.60622699
55MP0005645_abnormal_hypothalamus_physiol1.59298149
56MP0002272_abnormal_nervous_system1.57347568
57MP0004885_abnormal_endolymph1.56847674
58MP0001986_abnormal_taste_sensitivity1.56509479
59MP0001486_abnormal_startle_reflex1.54886273
60MP0004147_increased_porphyrin_level1.53640388
61MP0002938_white_spotting1.48600273
62MP0005670_abnormal_white_adipose1.42987328
63MP0001984_abnormal_olfaction1.42317380
64MP0005397_hematopoietic_system_phenotyp1.41428630
65MP0001545_abnormal_hematopoietic_system1.41428630
66MP0001672_abnormal_embryogenesis/_devel1.39954879
67MP0005380_embryogenesis_phenotype1.39954879
68MP0005451_abnormal_body_composition1.38860471
69MP0005365_abnormal_bile_salt1.37023771
70MP0000631_abnormal_neuroendocrine_gland1.36792371
71MP0003186_abnormal_redox_activity1.36509919
72MP0003878_abnormal_ear_physiology1.33554038
73MP0005377_hearing/vestibular/ear_phenot1.33554038
74MP0004145_abnormal_muscle_electrophysio1.31990044
75MP0010386_abnormal_urinary_bladder1.31621779
76MP0001905_abnormal_dopamine_level1.28988917
77MP0003880_abnormal_central_pattern1.27160619
78MP0005075_abnormal_melanosome_morpholog1.26109032
79MP0005389_reproductive_system_phenotype1.25794302
80MP0002733_abnormal_thermal_nociception1.25240782
81MP0000313_abnormal_cell_death1.24918895
82MP0001485_abnormal_pinna_reflex1.24762052
83MP0001697_abnormal_embryo_size1.24619523
84MP0002405_respiratory_system_inflammati1.24410949
85MP0006292_abnormal_olfactory_placode1.22979168
86MP0001970_abnormal_pain_threshold1.20307579
87MP0002080_prenatal_lethality1.19536142
88MP0005386_behavior/neurological_phenoty1.19316551
89MP0004924_abnormal_behavior1.19316551
90MP0002572_abnormal_emotion/affect_behav1.19142607
91MP0000689_abnormal_spleen_morphology1.17311879
92MP0002086_abnormal_extraembryonic_tissu1.17231550
93MP0001145_abnormal_male_reproductive1.16489163
94MP0002085_abnormal_embryonic_tissue1.15871153
95MP0005084_abnormal_gallbladder_morpholo1.15128574
96MP0002557_abnormal_social/conspecific_i1.14413089
97MP0005379_endocrine/exocrine_gland_phen1.13613727
98MP0002019_abnormal_tumor_incidence1.13389305
99MP0003315_abnormal_perineum_morphology1.13291747
100MP0003252_abnormal_bile_duct1.12653701
101MP0008775_abnormal_heart_ventricle1.12621280
102MP0002064_seizures1.12479947
103MP0000358_abnormal_cell_content/1.11926232
104MP0000230_abnormal_systemic_arterial1.11603910
105MP0003984_embryonic_growth_retardation1.11164711
106MP0001929_abnormal_gametogenesis1.11048629
107MP0004215_abnormal_myocardial_fiber1.10808878
108MP0002160_abnormal_reproductive_system1.10682627
109MP0005167_abnormal_blood-brain_barrier1.10219851
110MP0001919_abnormal_reproductive_system1.09985227
111MP0009840_abnormal_foam_cell1.09805626
112MP0002088_abnormal_embryonic_growth/wei1.09165245
113MP0010329_abnormal_lipoprotein_level1.08912565
114MP0002735_abnormal_chemical_nociception1.08655168
115MP0000371_diluted_coat_color1.06915340
116MP0002067_abnormal_sensory_capabilities1.06420109
117MP0002138_abnormal_hepatobiliary_system1.05340005
118MP0002210_abnormal_sex_determination1.05136305
119MP0005195_abnormal_posterior_eye1.04697274
120MP0003890_abnormal_embryonic-extraembry1.04052450
121MP0002722_abnormal_immune_system1.03566057
122MP0005621_abnormal_cell_physiology1.01488070
123MP0002095_abnormal_skin_pigmentation0.99922179
124MP0000383_abnormal_hair_follicle0.98613361
125MP0004130_abnormal_muscle_cell0.98595409
126MP0005384_cellular_phenotype0.97342951
127MP0006082_CNS_inflammation0.96170893
128MP0001529_abnormal_vocalization0.96113734
129MP0002928_abnormal_bile_duct0.95406383
130MP0003938_abnormal_ear_development0.94739323
131MP0003448_altered_tumor_morphology0.92130486
132MP0005085_abnormal_gallbladder_physiolo0.91492040
133MP0002396_abnormal_hematopoietic_system0.90344412
134MP0002163_abnormal_gland_morphology0.89697554
135MP0005410_abnormal_fertilization0.89266543
136MP0001502_abnormal_circadian_rhythm0.88705763
137MP0001324_abnormal_eye_pigmentation0.87423455
138MP0003137_abnormal_impulse_conducting0.87248706
139MP0003635_abnormal_synaptic_transmissio0.86989279
140MP0000858_altered_metastatic_potential0.86642688
141MP0002398_abnormal_bone_marrow0.86020490
142MP0004742_abnormal_vestibular_system0.85982666
143MP0002693_abnormal_pancreas_physiology0.85856825
144MP0006035_abnormal_mitochondrial_morpho0.85057803
145MP0005187_abnormal_penis_morphology0.84946197
146MP0005332_abnormal_amino_acid0.84677804
147MP0002084_abnormal_developmental_patter0.84311168
148MP0002229_neurodegeneration0.83963555
149MP0005310_abnormal_salivary_gland0.83567656
150MP0005448_abnormal_energy_balance0.82767053
151MP0008877_abnormal_DNA_methylation0.82601371
152MP0002909_abnormal_adrenal_gland0.82160996
153MP0005171_absent_coat_pigmentation0.82081251
154MP0003656_abnormal_erythrocyte_physiolo0.81864375
155MP0000703_abnormal_thymus_morphology0.81778891
156MP0000653_abnormal_sex_gland0.81278620
157MP0002063_abnormal_learning/memory/cond0.80850807
158MP0001800_abnormal_humoral_immune0.80681851
159MP0004133_heterotaxia0.80630621
160MP0000647_abnormal_sebaceous_gland0.80351192
161MP0003950_abnormal_plasma_membrane0.80140160
162MP0000750_abnormal_muscle_regeneration0.79449535
163MP0000538_abnormal_urinary_bladder0.78409764
164MP0002752_abnormal_somatic_nervous0.78127730
165MP0003806_abnormal_nucleotide_metabolis0.75902920
166MP0002429_abnormal_blood_cell0.75508767
167MP0002723_abnormal_immune_serum0.75161199
168MP0003436_decreased_susceptibility_to0.74280326
169MP0002452_abnormal_antigen_presenting0.72862104
170MP0001542_abnormal_bone_strength0.72132517
171MP0000716_abnormal_immune_system0.71722761
172MP0002420_abnormal_adaptive_immunity0.71466593
173MP0006036_abnormal_mitochondrial_physio0.71455449
174MP0004197_abnormal_fetal_growth/weight/0.70795465
175MP0008995_early_reproductive_senescence0.70207480
176MP0005174_abnormal_tail_pigmentation0.69879890
177MP0001819_abnormal_immune_cell0.69819252
178MP0001873_stomach_inflammation0.69596826
179MP0001845_abnormal_inflammatory_respons0.69543682
180MP0003221_abnormal_cardiomyocyte_apopto0.67711503
181MP0004808_abnormal_hematopoietic_stem0.67056137
182MP0003453_abnormal_keratinocyte_physiol0.66515317
183MP0001764_abnormal_homeostasis0.65623598
184MP0002419_abnormal_innate_immunity0.65036647
185MP0003828_pulmonary_edema0.64992391
186MP0003698_abnormal_male_reproductive0.64509226
187MP0005395_other_phenotype0.63288318
188MP0005266_abnormal_metabolism0.61034920
189MP0001119_abnormal_female_reproductive0.60272928

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.12520812
2Pancreatic cysts (HP:0001737)4.61523832
3Carpal bone hypoplasia (HP:0001498)4.61502949
4Breast hypoplasia (HP:0003187)4.49698701
5Pancreatic fibrosis (HP:0100732)4.27567209
6Abnormality of midbrain morphology (HP:0002418)4.23735332
7Molar tooth sign on MRI (HP:0002419)4.23735332
8Congenital stationary night blindness (HP:0007642)4.22802656
9Impulsivity (HP:0100710)4.19226111
10True hermaphroditism (HP:0010459)4.06018063
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.91363617
12Pustule (HP:0200039)3.78982845
13Nephronophthisis (HP:0000090)3.74100242
14Cerebral hypomyelination (HP:0006808)3.64652202
15Abnormality of the renal cortex (HP:0011035)3.42621945
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37960319
17Attenuation of retinal blood vessels (HP:0007843)3.36013060
18Multiple enchondromatosis (HP:0005701)3.28963783
19Type II lissencephaly (HP:0007260)3.28323882
20Abnormality of the renal medulla (HP:0100957)3.26600934
21Degeneration of anterior horn cells (HP:0002398)3.25872894
22Abnormality of the anterior horn cell (HP:0006802)3.25872894
23Hyperventilation (HP:0002883)3.24906525
24Abolished electroretinogram (ERG) (HP:0000550)3.17347467
25Premature ovarian failure (HP:0008209)3.17245213
26Medial flaring of the eyebrow (HP:0010747)3.15113988
27Progressive muscle weakness (HP:0003323)3.14785731
28Hyperglycinemia (HP:0002154)3.14572330
29Chronic hepatic failure (HP:0100626)3.08827528
30Abnormal rod and cone electroretinograms (HP:0008323)3.02666661
31Genetic anticipation (HP:0003743)3.01539993
32Cystic liver disease (HP:0006706)2.99795307
33Short chin (HP:0000331)2.98628441
34Abnormality of the ileum (HP:0001549)2.96969310
35Meckel diverticulum (HP:0002245)2.94390116
36Chromsome breakage (HP:0040012)2.92215758
37Dysautonomia (HP:0002459)2.90846209
38Patellar aplasia (HP:0006443)2.89716871
39Rectovaginal fistula (HP:0000143)2.88158010
40Rectal fistula (HP:0100590)2.88158010
41Progressive cerebellar ataxia (HP:0002073)2.86862672
42Tubular atrophy (HP:0000092)2.86293646
43Gaze-evoked nystagmus (HP:0000640)2.83613009
44Rough bone trabeculation (HP:0100670)2.83058183
45Abnormality of the labia minora (HP:0012880)2.80487089
46Aplasia/hypoplasia of the humerus (HP:0006507)2.76184096
47Abnormal drinking behavior (HP:0030082)2.75817740
48Polydipsia (HP:0001959)2.75817740
49Pendular nystagmus (HP:0012043)2.74614128
50Aplasia/Hypoplasia of the patella (HP:0006498)2.68345581
51Microretrognathia (HP:0000308)2.67865806
52Absent radius (HP:0003974)2.67306049
53Inability to walk (HP:0002540)2.64351783
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62426356
55Abnormality of alanine metabolism (HP:0010916)2.62426356
56Hyperalaninemia (HP:0003348)2.62426356
57Abnormality of liposaccharide metabolism (HP:0010968)2.61284043
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.61284043
59Abnormality of glycolipid metabolism (HP:0010969)2.61284043
60Hyperglycinuria (HP:0003108)2.60712835
61Increased corneal curvature (HP:0100692)2.60065582
62Keratoconus (HP:0000563)2.60065582
63Decreased subcutaneous fat (HP:0001002)2.58053824
64Hypothermia (HP:0002045)2.57667191
65Trismus (HP:0000211)2.57402743
66Ureteral duplication (HP:0000073)2.57227031
67Large for gestational age (HP:0001520)2.55832180
68Abnormality of the preputium (HP:0100587)2.54476863
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.51685614
70Personality changes (HP:0000751)2.50066843
71Intestinal fistula (HP:0100819)2.49852743
72Progressive inability to walk (HP:0002505)2.48898717
73Sclerocornea (HP:0000647)2.48655778
74Renal cortical cysts (HP:0000803)2.48324281
75Congenital, generalized hypertrichosis (HP:0004540)2.48107925
76Decreased central vision (HP:0007663)2.47732579
77Absent thumb (HP:0009777)2.46345936
78Short humerus (HP:0005792)2.42736031
79Bone marrow hypocellularity (HP:0005528)2.42303324
80Aplasia involving forearm bones (HP:0009822)2.41554005
81Absent forearm bone (HP:0003953)2.41554005
82Aplasia/Hypoplasia of the tibia (HP:0005772)2.39171992
83Vaginal fistula (HP:0004320)2.38663905
84Gait imbalance (HP:0002141)2.38525694
85Bony spicule pigmentary retinopathy (HP:0007737)2.37680232
86Rib fusion (HP:0000902)2.37546957
87Vacuolated lymphocytes (HP:0001922)2.35752571
88Facial hemangioma (HP:0000329)2.33342340
89Tongue fasciculations (HP:0001308)2.32390497
90Cheilitis (HP:0100825)2.31940320
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31667659
92Congenital primary aphakia (HP:0007707)2.31617130
93Bile duct proliferation (HP:0001408)2.29011990
94Abnormal biliary tract physiology (HP:0012439)2.29011990
95Congenital hepatic fibrosis (HP:0002612)2.28865080
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.28266497
97Lissencephaly (HP:0001339)2.27823863
98Cerebellar dysplasia (HP:0007033)2.27523721
99Microvesicular hepatic steatosis (HP:0001414)2.27068367
100Selective tooth agenesis (HP:0001592)2.25195594
101Maternal diabetes (HP:0009800)2.22822968
102Nephrogenic diabetes insipidus (HP:0009806)2.22094990
103Secondary amenorrhea (HP:0000869)2.21446870
104Furrowed tongue (HP:0000221)2.21216416
105Male pseudohermaphroditism (HP:0000037)2.19956468
106Polyuria (HP:0000103)2.19361897
107Recurrent abscess formation (HP:0002722)2.19307586
108Clumsiness (HP:0002312)2.18847138
109Small intestinal stenosis (HP:0012848)2.18628998
110Duodenal stenosis (HP:0100867)2.18628998
111Abnormality of subcutaneous fat tissue (HP:0001001)2.18496300
112Absent speech (HP:0001344)2.18024613
113Glossoptosis (HP:0000162)2.17866531
114Protruding tongue (HP:0010808)2.16385395
115Stomach cancer (HP:0012126)2.15846979
116Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15743736
117Broad-based gait (HP:0002136)2.15708539
118Atrophy/Degeneration involving motor neurons (HP:0007373)2.14726803
119Anencephaly (HP:0002323)2.11951238
120Abnormality of the umbilical cord (HP:0010881)2.11321706
121Muscle fibrillation (HP:0010546)2.10811473
122Decreased circulating renin level (HP:0003351)2.09361246
123Rhabdomyosarcoma (HP:0002859)2.08335909
124Spinal muscular atrophy (HP:0007269)2.06771333
125Myelodysplasia (HP:0002863)2.06724782
126Febrile seizures (HP:0002373)2.04530510
127Premature graying of hair (HP:0002216)2.04371283
128Anorexia (HP:0002039)2.03659148
129Increased CSF lactate (HP:0002490)2.03336074
130Abnormality of chromosome stability (HP:0003220)2.02431509
131Abnormal trabecular bone morphology (HP:0100671)2.02384752
132Areflexia of lower limbs (HP:0002522)2.01672912
133Steatorrhea (HP:0002570)2.01477747
134Genital tract atresia (HP:0001827)1.99872953
135Type I transferrin isoform profile (HP:0003642)1.99348871
136Fair hair (HP:0002286)1.98905287
137Abnormality of lateral ventricle (HP:0030047)1.96218471
138Hemiparesis (HP:0001269)1.94644923
139Sparse eyelashes (HP:0000653)1.93126065
140Postaxial foot polydactyly (HP:0001830)1.92991911
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91978734
142Chorioretinal atrophy (HP:0000533)1.91719770
143Abnormality of cells of the erythroid lineage (HP:0012130)1.91661660
144Abnormality of the pons (HP:0007361)1.91582845
145Abnormality of the duodenum (HP:0002246)1.91382686
146Optic nerve hypoplasia (HP:0000609)1.91337072
147Severe muscular hypotonia (HP:0006829)1.91301368
148Joint stiffness (HP:0001387)1.90958568
149Vaginal atresia (HP:0000148)1.90808154
1503-Methylglutaconic aciduria (HP:0003535)1.90452621
151Abnormality of the motor neurons (HP:0002450)1.90412306
152Abnormal neuron morphology (HP:0012757)1.90412306
153Abnormality of the fovea (HP:0000493)1.90402871
154Hypoplasia of the pons (HP:0012110)1.89702165
155Mitochondrial inheritance (HP:0001427)1.89551743
156Retinal dysplasia (HP:0007973)1.89264944
157Sloping forehead (HP:0000340)1.89251695
158Tracheoesophageal fistula (HP:0002575)1.88462926
159Death in infancy (HP:0001522)1.88148106
160Ependymoma (HP:0002888)1.88116012
161Supernumerary spleens (HP:0009799)1.87982936
162Congenital sensorineural hearing impairment (HP:0008527)1.87708018
163Gout (HP:0001997)1.86852379
164Reduced antithrombin III activity (HP:0001976)1.84290571
165Hypoplasia of the fovea (HP:0007750)1.83390366
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.83390366
167Absent/shortened dynein arms (HP:0200106)1.83370722
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.83370722
169Fused cervical vertebrae (HP:0002949)1.82732551
170CNS hypomyelination (HP:0003429)1.81967036
171Pachygyria (HP:0001302)1.81595756
172Prominent nose (HP:0000448)1.81575689
173Abnormality of macular pigmentation (HP:0008002)1.81299771
174Acute necrotizing encephalopathy (HP:0006965)1.80299725
175Premature loss of primary teeth (HP:0006323)1.79630999
176Abnormality of glycine metabolism (HP:0010895)1.79484776
177Abnormality of serine family amino acid metabolism (HP:0010894)1.79484776
178Prolonged neonatal jaundice (HP:0006579)1.77464125
179Thyroiditis (HP:0100646)1.77271377
180Concave nail (HP:0001598)1.77228030
181Upper motor neuron abnormality (HP:0002127)1.76684944
182Tachypnea (HP:0002789)1.76223106
183Optic disc pallor (HP:0000543)1.75650121
184Squamous cell carcinoma (HP:0002860)1.75299199
185Stenosis of the external auditory canal (HP:0000402)1.74522207
186Cleft eyelid (HP:0000625)1.74373616
187Abnormal urine output (HP:0012590)1.73627031
188Increased IgM level (HP:0003496)1.72903767
189Retinitis pigmentosa (HP:0000510)1.72607988
190Ketosis (HP:0001946)1.72550700
191Aplasia/Hypoplasia of the spleen (HP:0010451)1.71324657
192Postaxial hand polydactyly (HP:0001162)1.71178545
193Acute encephalopathy (HP:0006846)1.69763081
194Thyroid-stimulating hormone excess (HP:0002925)1.68702724
195Progressive macrocephaly (HP:0004481)1.67464031
196Constricted visual fields (HP:0001133)1.67275080

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.92139649
2BUB14.57954788
3STK164.04772980
4WEE13.83609053
5IRAK33.09021596
6CDK122.92119762
7ACVR1B2.90425416
8BMPR1B2.78862606
9NME22.72016210
10EIF2AK32.69977803
11NEK22.62877373
12TTK2.54615074
13WNK32.52868579
14TLK12.37130388
15WNK42.36884445
16BCKDK2.34091215
17MAP4K22.32752906
18NUAK12.21977474
19TESK22.12900030
20EIF2AK12.09442709
21MAP4K12.05947156
22PLK12.02877961
23INSRR2.00921373
24MAP3K111.94179235
25AKT31.93798106
26MAPK131.86798584
27EPHA21.86758673
28TSSK61.79414755
29PLK41.78783809
30PIM21.77463263
31CASK1.63946956
32STK391.54588867
33CDK71.52080962
34MAPKAPK31.51225708
35ERN11.50430798
36MAP3K41.50314547
37OXSR11.48763594
38MAP2K21.43958780
39CHEK21.38046479
40DYRK31.34163027
41RPS6KB21.34048819
42BRSK21.31772900
43PAK31.28354413
44ADRBK11.26077566
45DAPK21.25962838
46ZAP701.25660350
47PIM11.25018874
48PINK11.23618816
49MATK1.19747930
50VRK11.18781859
51PIK3CA1.17363448
52AURKA1.14944600
53EIF2AK21.14929250
54AURKB1.14744271
55SCYL21.11217135
56PRKCE1.04880726
57GRK51.04736697
58TGFBR10.99813976
59MAPK150.99285641
60SRPK10.98696538
61PLK30.98476106
62TRIM280.98305834
63TIE10.98197091
64STK30.97878710
65BRAF0.97245954
66TNIK0.95852835
67PHKG10.93369125
68PHKG20.93369125
69MAP3K60.93323844
70MARK10.92800443
71GRK60.92606868
72NTRK30.92067932
73PRKCG0.89512300
74CSK0.89499545
75MARK30.87894499
76MAP3K80.87625955
77PTK2B0.86476494
78CAMKK20.86055886
79PNCK0.85844018
80BRSK10.85395147
81MUSK0.83543356
82CDK40.82505535
83PRKAA20.81685973
84ADRBK20.80200156
85ZAK0.79792775
86STK100.78982034
87PAK40.78415133
88TEC0.77026099
89NLK0.76271720
90TXK0.75939335
91LATS20.75507081
92PLK20.75245677
93FGFR20.74835673
94ARAF0.74569186
95TYK20.74409823
96MAP2K60.74095757
97ATR0.73700331
98PRKCI0.73693393
99MAP2K70.72670552
100RPS6KA40.71891857
101TRPM70.71563508
102CHEK10.68808222
103BCR0.68093489
104CAMK10.67692532
105IRAK40.67407850
106CSNK1G10.67158764
107CSNK1G20.66895965
108STK40.66067532
109MST40.63826284
110CDK20.63018407
111KIT0.60832057
112PRKCQ0.59456102
113GRK10.58024914
114GRK70.57468474
115MAPKAPK50.57270474
116ICK0.57269445
117ALK0.56481458
118BLK0.55851226
119DYRK20.55669277
120CAMK2A0.55331691
121PKN10.55195690
122ERBB30.55124272
123CSNK2A10.54759317
124NEK10.54719357
125ITK0.54670656
126IKBKB0.54632791
127CHUK0.53483461
128STK380.52451184
129MTOR0.50772886
130IRAK10.50709836
131OBSCN0.50136596
132PRKACA0.49275878
133MYLK0.48577664
134MAP3K90.48288494
135CSNK1G30.47333334
136MAP3K70.47252584
137CSNK2A20.46500598
138CDC70.45719028
139STK110.45644577
140ATM0.45058944
141RPS6KA50.44796866
142FER0.42857269
143EPHA40.41859625
144MKNK20.41107686
145PAK10.41094301
146TYRO30.41091207
147TAOK30.40903476
148SGK20.40503599
149MAP2K10.40355795
150TNK20.40309165
151CSNK1A1L0.40277725
152TESK10.39708224
153STK38L0.39365009
154FLT30.38140297
155FGR0.37906320
156NME10.37121411
157CDK10.36693699
158DYRK1A0.36550563
159PRKG10.36307419
160PIK3CG0.35751492
161CSNK1D0.35311872
162DAPK10.35121003
163BMX0.34750569
164PRKCA0.34174343
165IGF1R0.33571713
166ABL20.33411219
167CDK30.32303410
168PRKCZ0.32213883
169PRKAA10.32189774
170NTRK20.31724959
171MKNK10.31012484
172CSNK1E0.30974750
173CSNK1A10.30628731
174PDK30.29769041
175PDK40.29769041
176TAOK10.29630210
177PDK20.29261919

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.96402913
2Vitamin B6 metabolism_Homo sapiens_hsa007503.85092074
3RNA polymerase_Homo sapiens_hsa030203.41685926
4DNA replication_Homo sapiens_hsa030302.97530562
5Phototransduction_Homo sapiens_hsa047442.79943473
6RNA transport_Homo sapiens_hsa030132.78901507
7Folate biosynthesis_Homo sapiens_hsa007902.77814488
8Proteasome_Homo sapiens_hsa030502.63400318
9Mismatch repair_Homo sapiens_hsa034302.62719386
10Butanoate metabolism_Homo sapiens_hsa006502.54904589
11Pancreatic secretion_Homo sapiens_hsa049722.48928253
12Ribosome_Homo sapiens_hsa030102.36419427
13Nitrogen metabolism_Homo sapiens_hsa009102.26204781
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.25012242
15Tryptophan metabolism_Homo sapiens_hsa003802.23101675
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20365401
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18426993
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11349096
19Homologous recombination_Homo sapiens_hsa034402.11203033
20One carbon pool by folate_Homo sapiens_hsa006702.02691912
21Pyrimidine metabolism_Homo sapiens_hsa002402.01267580
22Nicotine addiction_Homo sapiens_hsa050332.01178726
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00768336
24Base excision repair_Homo sapiens_hsa034101.99415565
25Cell cycle_Homo sapiens_hsa041101.97314543
26Fanconi anemia pathway_Homo sapiens_hsa034601.93374569
27Ether lipid metabolism_Homo sapiens_hsa005651.83937889
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83423840
29Spliceosome_Homo sapiens_hsa030401.83422823
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83177636
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80369260
32ABC transporters_Homo sapiens_hsa020101.71703601
33p53 signaling pathway_Homo sapiens_hsa041151.71691338
34Fat digestion and absorption_Homo sapiens_hsa049751.70952274
35Nucleotide excision repair_Homo sapiens_hsa034201.70576862
36Oxidative phosphorylation_Homo sapiens_hsa001901.68522889
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.66975391
38Propanoate metabolism_Homo sapiens_hsa006401.64726391
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.63963198
40Fructose and mannose metabolism_Homo sapiens_hsa000511.61873628
41Protein digestion and absorption_Homo sapiens_hsa049741.60716913
42Caffeine metabolism_Homo sapiens_hsa002321.60476209
43Basal transcription factors_Homo sapiens_hsa030221.57574291
44Regulation of autophagy_Homo sapiens_hsa041401.51934827
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50574278
46Taste transduction_Homo sapiens_hsa047421.47428561
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.43513493
48Olfactory transduction_Homo sapiens_hsa047401.42866748
49Other glycan degradation_Homo sapiens_hsa005111.38162663
50Morphine addiction_Homo sapiens_hsa050321.35308236
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31539888
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.31153727
53Epstein-Barr virus infection_Homo sapiens_hsa051691.27414116
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22919657
55Sulfur relay system_Homo sapiens_hsa041221.19619098
56Chemical carcinogenesis_Homo sapiens_hsa052041.19043662
57Ovarian steroidogenesis_Homo sapiens_hsa049131.18804823
58Histidine metabolism_Homo sapiens_hsa003401.17988395
59Retinol metabolism_Homo sapiens_hsa008301.17717780
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17004406
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16910208
62Parkinsons disease_Homo sapiens_hsa050121.16837505
63Peroxisome_Homo sapiens_hsa041461.14345600
64beta-Alanine metabolism_Homo sapiens_hsa004101.11935691
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.10970354
66Arginine and proline metabolism_Homo sapiens_hsa003301.10408821
67Lysosome_Homo sapiens_hsa041421.10048044
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.09423390
69Biosynthesis of amino acids_Homo sapiens_hsa012301.08912301
70Arachidonic acid metabolism_Homo sapiens_hsa005901.07656220
71Purine metabolism_Homo sapiens_hsa002301.07335377
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05475014
73RNA degradation_Homo sapiens_hsa030181.04049923
74Linoleic acid metabolism_Homo sapiens_hsa005911.03673878
75Vitamin digestion and absorption_Homo sapiens_hsa049771.02077088
76Insulin secretion_Homo sapiens_hsa049111.01521003
77Circadian entrainment_Homo sapiens_hsa047131.00397700
78Non-homologous end-joining_Homo sapiens_hsa034501.00007863
79mRNA surveillance pathway_Homo sapiens_hsa030150.99522661
80Circadian rhythm_Homo sapiens_hsa047100.99057269
81Pentose phosphate pathway_Homo sapiens_hsa000300.98427585
82GABAergic synapse_Homo sapiens_hsa047270.95392536
83Serotonergic synapse_Homo sapiens_hsa047260.94496987
84Glycerolipid metabolism_Homo sapiens_hsa005610.94140878
85Glutamatergic synapse_Homo sapiens_hsa047240.93848485
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89160740
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88024635
88Cardiac muscle contraction_Homo sapiens_hsa042600.87487516
89Fatty acid degradation_Homo sapiens_hsa000710.85615996
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85434597
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80805234
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.77866875
93Salivary secretion_Homo sapiens_hsa049700.77540945
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74853704
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74644673
96Calcium signaling pathway_Homo sapiens_hsa040200.74460482
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71724340
98Alzheimers disease_Homo sapiens_hsa050100.71088048
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71002184
100Protein export_Homo sapiens_hsa030600.70651288
101Glutathione metabolism_Homo sapiens_hsa004800.70550341
102Oocyte meiosis_Homo sapiens_hsa041140.70099988
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68304110
104Legionellosis_Homo sapiens_hsa051340.67834733
105Renin-angiotensin system_Homo sapiens_hsa046140.66945214
106Apoptosis_Homo sapiens_hsa042100.66636189
107mTOR signaling pathway_Homo sapiens_hsa041500.66467844
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.66455272
109Notch signaling pathway_Homo sapiens_hsa043300.65161153
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64575638
111Fatty acid metabolism_Homo sapiens_hsa012120.63037693
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62278437
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.62257473
114Dorso-ventral axis formation_Homo sapiens_hsa043200.62249991
115Fatty acid biosynthesis_Homo sapiens_hsa000610.62182940
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60255619
117Influenza A_Homo sapiens_hsa051640.59604554
118Herpes simplex infection_Homo sapiens_hsa051680.59548786
119Collecting duct acid secretion_Homo sapiens_hsa049660.59396623
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.58589904
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.58289337
122Viral carcinogenesis_Homo sapiens_hsa052030.57669851
123Antigen processing and presentation_Homo sapiens_hsa046120.55151517
124Type I diabetes mellitus_Homo sapiens_hsa049400.54139981
125Galactose metabolism_Homo sapiens_hsa000520.53231216
126Asthma_Homo sapiens_hsa053100.51808027
127Sulfur metabolism_Homo sapiens_hsa009200.51651883
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.49988092
129Mineral absorption_Homo sapiens_hsa049780.49734016
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49699031
131Fatty acid elongation_Homo sapiens_hsa000620.47119187
132Dopaminergic synapse_Homo sapiens_hsa047280.45735240
133Tyrosine metabolism_Homo sapiens_hsa003500.43940552
134Steroid biosynthesis_Homo sapiens_hsa001000.42648324
135Graft-versus-host disease_Homo sapiens_hsa053320.41820955
136Metabolic pathways_Homo sapiens_hsa011000.40875875
137Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39863776
138Inositol phosphate metabolism_Homo sapiens_hsa005620.38745515
139Long-term depression_Homo sapiens_hsa047300.38032435
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36773200
141Selenocompound metabolism_Homo sapiens_hsa004500.35846106
142PPAR signaling pathway_Homo sapiens_hsa033200.34582055
143cAMP signaling pathway_Homo sapiens_hsa040240.33900126
144Renin secretion_Homo sapiens_hsa049240.33889532
145Measles_Homo sapiens_hsa051620.33738039
146Oxytocin signaling pathway_Homo sapiens_hsa049210.33465317
147Allograft rejection_Homo sapiens_hsa053300.32274912
148Autoimmune thyroid disease_Homo sapiens_hsa053200.31497984
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30920899
150RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28930132
151Leishmaniasis_Homo sapiens_hsa051400.28252309
152Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27728522
153Hematopoietic cell lineage_Homo sapiens_hsa046400.27683449
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27235160
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25797957
156NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25526975
157Small cell lung cancer_Homo sapiens_hsa052220.25516286
158Primary immunodeficiency_Homo sapiens_hsa053400.24649552
159Tuberculosis_Homo sapiens_hsa051520.20350792
160Huntingtons disease_Homo sapiens_hsa050160.19812955
161Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.19677075
162HTLV-I infection_Homo sapiens_hsa051660.19461060
163Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18961397
164Staphylococcus aureus infection_Homo sapiens_hsa051500.18510220
165Shigellosis_Homo sapiens_hsa051310.17429990
166Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16600367
167HIF-1 signaling pathway_Homo sapiens_hsa040660.16061497
168Phagosome_Homo sapiens_hsa041450.15937184
169MicroRNAs in cancer_Homo sapiens_hsa052060.15011914
170Acute myeloid leukemia_Homo sapiens_hsa052210.12195136

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