PKD1L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.65638265
2cell wall macromolecule metabolic process (GO:0044036)9.26677405
3cell wall macromolecule catabolic process (GO:0016998)9.26677405
4multicellular organism reproduction (GO:0032504)8.91782536
5cilium or flagellum-dependent cell motility (GO:0001539)8.81591694
6sperm-egg recognition (GO:0035036)8.68895910
7plasma membrane fusion (GO:0045026)8.31932197
8regulation of female gonad development (GO:2000194)8.29325599
9acrosome reaction (GO:0007340)8.24263218
10regulation of DNA methylation (GO:0044030)8.10787724
11cell-cell recognition (GO:0009988)7.98346699
12regulation of acrosome reaction (GO:0060046)7.80845349
13acrosome assembly (GO:0001675)7.72304781
14binding of sperm to zona pellucida (GO:0007339)7.68994371
15motile cilium assembly (GO:0044458)7.67303023
16reproduction (GO:0000003)7.59655461
17axonemal dynein complex assembly (GO:0070286)7.35650006
18epithelial cilium movement (GO:0003351)7.24702259
19spermatid development (GO:0007286)7.08140434
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.23738780
21retinal cone cell development (GO:0046549)6.20530065
22regulation of cilium movement (GO:0003352)6.02583622
23cilium movement (GO:0003341)5.82702732
24piRNA metabolic process (GO:0034587)5.73166952
25single fertilization (GO:0007338)5.69541965
26oocyte development (GO:0048599)5.64785071
27female gamete generation (GO:0007292)5.57445180
28glycine transport (GO:0015816)5.48144582
29synaptonemal complex organization (GO:0070193)5.45555690
30microtubule depolymerization (GO:0007019)5.41186684
31male meiosis (GO:0007140)5.40384060
32synaptonemal complex assembly (GO:0007130)5.37293348
33positive regulation of histone H3-K4 methylation (GO:0051571)5.37202965
34monoubiquitinated protein deubiquitination (GO:0035520)5.12698027
35negative regulation of inclusion body assembly (GO:0090084)5.07362603
36regulation of steroid hormone secretion (GO:2000831)4.94652126
37fertilization (GO:0009566)4.84804634
38sperm capacitation (GO:0048240)4.79689771
39spermatogenesis (GO:0007283)4.78366897
40male gamete generation (GO:0048232)4.76829307
41regulation of female receptivity (GO:0045924)4.67876769
42positive regulation of uterine smooth muscle contraction (GO:0070474)4.60781298
43relaxation of smooth muscle (GO:0044557)4.60263345
44negative regulation of reproductive process (GO:2000242)4.46472694
45gamete generation (GO:0007276)4.39806314
46synapsis (GO:0007129)4.34405427
47organic cation transport (GO:0015695)4.26405958
48male meiosis I (GO:0007141)4.25139224
49chromosome condensation (GO:0030261)4.07482323
50regulation of inclusion body assembly (GO:0090083)4.06908607
51ventricular system development (GO:0021591)4.04615418
52positive regulation of catecholamine secretion (GO:0033605)4.02638530
53DNA packaging (GO:0006323)4.01771857
54cellular process involved in reproduction in multicellular organism (GO:0022412)4.01096352
55protein kinase C signaling (GO:0070528)3.96797661
56nuclear pore complex assembly (GO:0051292)3.93126184
57attachment of spindle microtubules to kinetochore (GO:0008608)3.92752088
58female mating behavior (GO:0060180)3.91646131
59germ cell development (GO:0007281)3.91599903
60negative regulation of histone methylation (GO:0031061)3.88378801
61mitotic sister chromatid cohesion (GO:0007064)3.87052315
62chromosome organization involved in meiosis (GO:0070192)3.85326999
63meiotic nuclear division (GO:0007126)3.84179401
64positive regulation of humoral immune response (GO:0002922)3.83610237
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78558171
66meiosis I (GO:0007127)3.73519707
67positive regulation of reproductive process (GO:2000243)3.64665640
68type B pancreatic cell development (GO:0003323)3.64468654
69positive regulation of gastrulation (GO:2000543)3.59172347
70L-amino acid import (GO:0043092)3.54130116
71positive regulation of gamma-delta T cell activation (GO:0046645)3.54051043
72protein localization to chromosome, centromeric region (GO:0071459)3.53287450
73negative regulation of cAMP-mediated signaling (GO:0043951)3.51408913
74calcium ion-dependent exocytosis (GO:0017156)3.49411856
75oogenesis (GO:0048477)3.47713758
76mitotic chromosome condensation (GO:0007076)3.47424456
77DNA methylation involved in gamete generation (GO:0043046)3.47005402
78regulation of cytokine production involved in inflammatory response (GO:1900015)3.46496574
79cell recognition (GO:0008037)3.44772679
80multicellular organismal reproductive process (GO:0048609)3.43825951
81centriole assembly (GO:0098534)3.41845061
82N-terminal protein amino acid acetylation (GO:0006474)3.41689197
83pore complex assembly (GO:0046931)3.41054320
84regulation of histone H3-K4 methylation (GO:0051569)3.40947654
85regulation of uterine smooth muscle contraction (GO:0070472)3.37501822
86aggressive behavior (GO:0002118)3.36648133
87phosphorelay signal transduction system (GO:0000160)3.35758041
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35598423
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35598423
90positive regulation of mitotic sister chromatid separation (GO:1901970)3.35598423
91seminiferous tubule development (GO:0072520)3.28834114
92regulation of steroid hormone biosynthetic process (GO:0090030)3.28725512
93regulation of cell maturation (GO:1903429)3.28588633
94primitive streak formation (GO:0090009)3.26796520
95positive regulation of B cell differentiation (GO:0045579)3.25857382
96genitalia morphogenesis (GO:0035112)3.24689806
97sleep (GO:0030431)3.22735717
98microtubule severing (GO:0051013)3.21490751
99nuclear pore organization (GO:0006999)3.20605748
100meiotic cell cycle (GO:0051321)3.19503592
101nucleus organization (GO:0006997)3.15613766
102regulation of meiosis (GO:0040020)3.15031734
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09933450
104single strand break repair (GO:0000012)3.08195646
105regulation of spindle checkpoint (GO:0090231)3.07930885
106spermatid nucleus differentiation (GO:0007289)3.07821237
107centriole replication (GO:0007099)3.06070123
108glycerol ether metabolic process (GO:0006662)3.05552505
109regulation of histone H3-K9 methylation (GO:0051570)3.00657792
110gene silencing by RNA (GO:0031047)3.00025622
111negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.98057488
112regulation of corticosteroid hormone secretion (GO:2000846)2.97237905
113sexual reproduction (GO:0019953)2.97210701
114regulation of microtubule-based movement (GO:0060632)2.97136910
115phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.96837997
116positive regulation of chromosome segregation (GO:0051984)2.96666015
117regulation of penile erection (GO:0060405)2.93591591
118DNA methylation (GO:0006306)2.91979296
119DNA alkylation (GO:0006305)2.91979296
120regulation of reproductive process (GO:2000241)2.90746089
121positive regulation of histone methylation (GO:0031062)2.89711680
122meiotic cell cycle process (GO:1903046)2.88808019
123negative regulation of execution phase of apoptosis (GO:1900118)2.88531537
124negative regulation of hormone biosynthetic process (GO:0032353)2.88056611
125regulation of centriole replication (GO:0046599)2.85127375
126polyamine biosynthetic process (GO:0006596)2.85089867
127negative regulation of hormone metabolic process (GO:0032351)2.84647675
128regulation of hypersensitivity (GO:0002883)2.78238012
129positive regulation of meiotic cell cycle (GO:0051446)2.78150852
130regulation of meiotic cell cycle (GO:0051445)2.78130605
131microtubule polymerization or depolymerization (GO:0031109)2.77357153
132ether metabolic process (GO:0018904)2.76114251
133regulation of histone methylation (GO:0031060)2.74922500
134histone H3-K9 demethylation (GO:0033169)2.74573357
135positive regulation of meiosis (GO:0045836)2.74089293
136detection of light stimulus involved in sensory perception (GO:0050962)2.72345608
137detection of light stimulus involved in visual perception (GO:0050908)2.72345608
138regulation of calcium ion-dependent exocytosis (GO:0017158)2.72191951
139positive regulation of endothelial cell differentiation (GO:0045603)2.72043782
140chaperone-mediated protein complex assembly (GO:0051131)2.71491631
141regulation of norepinephrine secretion (GO:0014061)2.71141783
142somite rostral/caudal axis specification (GO:0032525)2.70148393
143mitotic nuclear envelope disassembly (GO:0007077)2.69979996
144DNA replication-dependent nucleosome organization (GO:0034723)2.69853942
145DNA replication-dependent nucleosome assembly (GO:0006335)2.69853942
146regulation of meiosis I (GO:0060631)2.69793467
147multicellular organismal development (GO:0007275)2.64122985
148gene silencing (GO:0016458)2.59907929
149sister chromatid cohesion (GO:0007062)2.59680473
150regulation of gamma-delta T cell differentiation (GO:0045586)2.58346847
151regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55844926
152regulation of gamma-delta T cell activation (GO:0046643)2.54101897
153membrane disassembly (GO:0030397)2.52925984
154nuclear envelope disassembly (GO:0051081)2.52925984
155histone exchange (GO:0043486)2.50673648
156translesion synthesis (GO:0019985)2.50402484
157antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.46890831
158antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.46890831
159left/right pattern formation (GO:0060972)2.42196723
160antigen processing and presentation of endogenous antigen (GO:0019883)2.39795149
161cellular hyperosmotic response (GO:0071474)2.39310804
162regulation of B cell differentiation (GO:0045577)2.39037689
163positive thymic T cell selection (GO:0045059)2.37793054
164DNA conformation change (GO:0071103)2.37276310
165negative regulation of necroptotic process (GO:0060546)2.35936610
166chromatin silencing (GO:0006342)2.34948715
167DNA strand renaturation (GO:0000733)2.34521914
168protein localization to kinetochore (GO:0034501)2.33118690
169negative regulation of retinoic acid receptor signaling pathway (GO:0048387)15.0448963
170regulation of retinoic acid receptor signaling pathway (GO:0048385)12.6639940
171fusion of sperm to egg plasma membrane (GO:0007342)11.0958798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.85394159
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.94688146
3E2F7_22180533_ChIP-Seq_HELA_Human5.31170566
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.11857769
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26325669
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16608916
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07105249
8GBX2_23144817_ChIP-Seq_PC3_Human3.06661172
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.06393748
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.89406073
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.87354381
12ZNF274_21170338_ChIP-Seq_K562_Hela2.61640715
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55669137
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.35659739
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.25758437
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.25758437
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.25758437
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24796447
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03918944
20EZH2_22144423_ChIP-Seq_EOC_Human2.03121034
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.88835099
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.85624967
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84603844
24MYC_22102868_ChIP-Seq_BL_Human1.82527164
25MYB_26560356_Chip-Seq_TH2_Human1.82447074
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82255242
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76104083
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74198123
29SCL_19346495_ChIP-Seq_HPC-7_Human1.71710557
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69765504
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68573960
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66259867
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.65345999
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63552174
35MYB_26560356_Chip-Seq_TH1_Human1.63412597
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.63310092
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.58491504
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58444950
39IRF1_19129219_ChIP-ChIP_H3396_Human1.57881824
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57517318
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.56794590
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54013379
43CBP_20019798_ChIP-Seq_JUKART_Human1.54013379
44FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52763828
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51979162
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51242242
47ER_23166858_ChIP-Seq_MCF-7_Human1.49337507
48SMAD4_21799915_ChIP-Seq_A2780_Human1.48717821
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48465306
50NANOG_20526341_ChIP-Seq_ESCs_Human1.47982504
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.46167503
52TCF4_23295773_ChIP-Seq_U87_Human1.44605570
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44596878
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44596878
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.44024860
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.40734362
57STAT3_23295773_ChIP-Seq_U87_Human1.38569734
58AR_25329375_ChIP-Seq_VCAP_Human1.37631879
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37623921
60EWS_26573619_Chip-Seq_HEK293_Human1.37366429
61* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.36847863
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.36260414
63* PRDM14_20953172_ChIP-Seq_ESCs_Human1.35932681
64UTX_26944678_Chip-Seq_JUKART_Human1.34296849
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33653191
66ELK4_26923725_Chip-Seq_MESODERM_Mouse1.33600472
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33579749
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33434130
69BCAT_22108803_ChIP-Seq_LS180_Human1.31180926
70P300_19829295_ChIP-Seq_ESCs_Human1.29453934
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27966684
72TCF7_22412390_ChIP-Seq_EML_Mouse1.27469784
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.27325636
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26333041
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25059078
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23911690
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21877575
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21812483
79IGF1R_20145208_ChIP-Seq_DFB_Human1.21178040
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21162362
81RUNX2_22187159_ChIP-Seq_PCA_Human1.21078323
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20839933
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.19679237
84AHR_22903824_ChIP-Seq_MCF-7_Human1.19037167
85MAF_26560356_Chip-Seq_TH1_Human1.18880797
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18538466
87TP53_22573176_ChIP-Seq_HFKS_Human1.18356139
88FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17654346
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.16254668
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.16096310
91TBL1_22424771_ChIP-Seq_293T_Human1.15815121
92GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.14433151
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14406865
94CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13895946
95FOXH1_21741376_ChIP-Seq_EPCs_Human1.13260099
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.12834028
97KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12010584
98STAT1_17558387_ChIP-Seq_HELA_Human1.11659028
99GATA3_27048872_Chip-Seq_THYMUS_Human1.11180471
100NANOG_19829295_ChIP-Seq_ESCs_Human1.11043562
101SOX2_19829295_ChIP-Seq_ESCs_Human1.11043562
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10453083
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10147235
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.10134667
105GATA3_21867929_ChIP-Seq_CD8_Mouse1.09833488
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09405695
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.08655908
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06904894
109SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06654674
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06584176
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06154842
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05308435
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03857785
114FUS_26573619_Chip-Seq_HEK293_Human1.03133382
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.01568656
116TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01311770
117* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00724297
118EP300_21415370_ChIP-Seq_HL-1_Mouse0.99364867
119NFYB_21822215_ChIP-Seq_K562_Human0.99272157
120TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98149432
121GATA3_21867929_ChIP-Seq_TH1_Mouse0.97994107
122NCOR_22424771_ChIP-Seq_293T_Human0.97640964
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97462940
124CDX2_22108803_ChIP-Seq_LS180_Human0.97125750
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96456813
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95106971
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94965356
128TCF4_22108803_ChIP-Seq_LS180_Human0.94487289
129SPI1_23547873_ChIP-Seq_NB4_Human0.94287791
130SALL4_22934838_ChIP-ChIP_CD34+_Human0.94146134
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.93836636
132RUNX1_26923725_Chip-Seq_HPCs_Mouse0.93688724
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93599943
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93435418
135CBP_21632823_ChIP-Seq_H3396_Human0.93427107
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.92999312
137SPI1_26923725_Chip-Seq_HPCs_Mouse0.92648573
138OCT1_27270436_Chip-Seq_PROSTATE_Human0.92523077
139MAF_26560356_Chip-Seq_TH2_Human0.92319888
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92257166
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92021841
142VDR_21846776_ChIP-Seq_THP-1_Human0.92015161
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91543913
144ELF1_20517297_ChIP-Seq_JURKAT_Human0.90580318
145PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90462842
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89958110
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.89551095
148P53_21459846_ChIP-Seq_SAOS-2_Human0.89400244
149VDR_22108803_ChIP-Seq_LS180_Human0.89085637
150CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88733010
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88580645
152BCOR_27268052_Chip-Seq_Bcells_Human0.88469360
153SMRT_27268052_Chip-Seq_Bcells_Human0.87841261
154TAF15_26573619_Chip-Seq_HEK293_Human0.87419564
155KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87342770
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87240735
157E2F1_21310950_ChIP-Seq_MCF-7_Human0.87227575
158TP53_16413492_ChIP-PET_HCT116_Human0.86446244
159PHF8_20622854_ChIP-Seq_HELA_Human0.86405962
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85933052
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85892421
162SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85887211
163AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85794091
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85782897
165FLI1_21867929_ChIP-Seq_CD8_Mouse0.85564765
166RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.84934596
167HTT_18923047_ChIP-ChIP_STHdh_Human0.84902181
168SPI1_20517297_ChIP-Seq_HL60_Human0.84239676
169* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.83753939
170PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83740935
171GATA3_26560356_Chip-Seq_TH2_Human0.83647341
172SPI1_23127762_ChIP-Seq_K562_Human0.83250526
173KDM2B_26808549_Chip-Seq_REH_Human0.83047523
174PHF8_20622853_ChIP-Seq_HELA_Human0.83019861
175OCT4_20526341_ChIP-Seq_ESCs_Human0.83013346
176GATA3_26560356_Chip-Seq_TH1_Human0.82988418
177GF1_26923725_Chip-Seq_HPCs_Mouse0.82442267
178NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82419190
179HOXB7_26014856_ChIP-Seq_BT474_Human0.81956917
180VDR_24763502_ChIP-Seq_THP-1_Human0.81657059
181RXR_22108803_ChIP-Seq_LS180_Human0.81487655
182ETV1_20927104_ChIP-Seq_GIST48_Human0.80649613
183TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.79947876
184LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78813451
185TAF2_19829295_ChIP-Seq_ESCs_Human0.78694291
186BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.78505356
187GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78257710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect6.70717570
2MP0002138_abnormal_hepatobiliary_system4.60965004
3MP0008877_abnormal_DNA_methylation4.07531819
4MP0003698_abnormal_male_reproductive4.00656825
5MP0001929_abnormal_gametogenesis3.84319998
6MP0005360_urolithiasis3.65120067
7MP0008789_abnormal_olfactory_epithelium3.39346048
8MP0006292_abnormal_olfactory_placode3.38062779
9MP0002139_abnormal_hepatobiliary_system3.25374894
10MP0002653_abnormal_ependyma_morphology3.12327015
11MP0003879_abnormal_hair_cell2.85343448
12MP0005395_other_phenotype2.69724947
13MP0003111_abnormal_nucleus_morphology2.68031791
14MP0010094_abnormal_chromosome_stability2.65656436
15MP0010234_abnormal_vibrissa_follicle2.52366721
16MP0002210_abnormal_sex_determination2.49966771
17MP0005646_abnormal_pituitary_gland2.43175313
18MP0003136_yellow_coat_color2.28236415
19MP0003890_abnormal_embryonic-extraembry2.25998329
20MP0002161_abnormal_fertility/fecundity2.25266979
21MP0008057_abnormal_DNA_replication2.18928831
22MP0001800_abnormal_humoral_immune2.11623185
23MP0001145_abnormal_male_reproductive2.06464813
24MP0001835_abnormal_antigen_presentation2.03824794
25MP0005410_abnormal_fertilization10.4098686
26MP0003763_abnormal_thymus_physiology1.98567645
27MP0009840_abnormal_foam_cell1.94276927
28MP0005670_abnormal_white_adipose1.86131278
29MP0008058_abnormal_DNA_repair1.84851480
30MP0003195_calcinosis1.84821790
31MP0002398_abnormal_bone_marrow1.84385594
32MP0000685_abnormal_immune_system1.80939338
33MP0000653_abnormal_sex_gland1.80769830
34MP0010368_abnormal_lymphatic_system1.78805851
35MP0002396_abnormal_hematopoietic_system1.78760004
36MP0005387_immune_system_phenotype1.77331887
37MP0001790_abnormal_immune_system1.77331887
38MP0004808_abnormal_hematopoietic_stem1.76369851
39MP0003693_abnormal_embryo_hatching1.70932366
40MP0001986_abnormal_taste_sensitivity1.69452558
41MP0005671_abnormal_response_to1.68674042
42MP0002723_abnormal_immune_serum1.68592270
43MP0006276_abnormal_autonomic_nervous1.67019436
44MP0002452_abnormal_antigen_presenting1.65833225
45MP0002405_respiratory_system_inflammati1.61035163
46MP0003303_peritoneal_inflammation1.58988379
47MP0004381_abnormal_hair_follicle1.57812382
48MP0003077_abnormal_cell_cycle1.57782823
49MP0008004_abnormal_stomach_pH1.57096626
50MP0003656_abnormal_erythrocyte_physiolo1.56881683
51MP0008995_early_reproductive_senescence1.56862249
52MP0005000_abnormal_immune_tolerance1.55729775
53MP0002638_abnormal_pupillary_reflex1.55643534
54MP0005551_abnormal_eye_electrophysiolog1.53098871
55MP0001502_abnormal_circadian_rhythm1.51941768
56MP0002420_abnormal_adaptive_immunity1.51891504
57MP0000689_abnormal_spleen_morphology1.51854023
58MP0010030_abnormal_orbit_morphology1.49792901
59MP0001819_abnormal_immune_cell1.49600203
60MP0003252_abnormal_bile_duct1.48258068
61MP0002722_abnormal_immune_system1.48016532
62MP0000703_abnormal_thymus_morphology1.47641052
63MP0000716_abnormal_immune_system1.42861735
64MP0005085_abnormal_gallbladder_physiolo1.42429283
65MP0001545_abnormal_hematopoietic_system1.41834113
66MP0005397_hematopoietic_system_phenotyp1.41834113
67MP0005464_abnormal_platelet_physiology1.38732648
68MP0010307_abnormal_tumor_latency1.36735202
69MP0001873_stomach_inflammation1.31636046
70MP0003786_premature_aging1.29664173
71MP0003646_muscle_fatigue1.27556720
72MP0002429_abnormal_blood_cell1.26775868
73MP0000631_abnormal_neuroendocrine_gland1.25679607
74MP0001664_abnormal_digestion1.24776302
75MP0002272_abnormal_nervous_system1.24687835
76MP0003950_abnormal_plasma_membrane1.22961124
77MP0003300_gastrointestinal_ulcer1.20296159
78MP0003436_decreased_susceptibility_to1.19210417
79MP0005025_abnormal_response_to1.16543428
80MP0002419_abnormal_innate_immunity1.15007856
81MP0000427_abnormal_hair_cycle1.12068709
82MP0010678_abnormal_skin_adnexa1.11607559
83MP0009278_abnormal_bone_marrow1.09311163
84MP0009785_altered_susceptibility_to1.08995771
85MP0002160_abnormal_reproductive_system1.08924736
86MP0001501_abnormal_sleep_pattern1.07854087
87MP0005451_abnormal_body_composition1.04278184
88MP0008775_abnormal_heart_ventricle1.03901779
89MP0004142_abnormal_muscle_tone1.03608716
90MP0001984_abnormal_olfaction1.02896646
91MP0005076_abnormal_cell_differentiation1.02825393
92MP0004947_skin_inflammation1.02117677
93MP0009333_abnormal_splenocyte_physiolog1.00745750
94MP0005623_abnormal_meninges_morphology1.00550245
95MP0002163_abnormal_gland_morphology1.00473649
96MP0006082_CNS_inflammation0.99663101
97MP0002234_abnormal_pharynx_morphology0.99084796
98MP0002148_abnormal_hypersensitivity_rea0.97924358
99MP0008007_abnormal_cellular_replicative0.96317706
100MP0005174_abnormal_tail_pigmentation0.94388393
101MP0004957_abnormal_blastocyst_morpholog0.94297755
102MP0010155_abnormal_intestine_physiology0.93423352
103MP0001845_abnormal_inflammatory_respons0.90906201
104MP0002019_abnormal_tumor_incidence0.89527397
105MP0002233_abnormal_nose_morphology0.88351790
106MP0002166_altered_tumor_susceptibility0.86657553
107MP0009697_abnormal_copulation0.86394920
108MP0005647_abnormal_sex_gland0.85784810
109MP0002127_abnormal_cardiovascular_syste0.84936082
110MP0000313_abnormal_cell_death0.83484300
111MP0000465_gastrointestinal_hemorrhage0.83338640
112MP0008875_abnormal_xenobiotic_pharmacok0.78995335
113MP0000490_abnormal_crypts_of0.77966564
114MP0001853_heart_inflammation0.74515433
115MP0008961_abnormal_basal_metabolism0.73073972
116MP0002971_abnormal_brown_adipose0.72011162
117MP0003787_abnormal_imprinting0.71819339
118MP0001293_anophthalmia0.71414043
119MP0003866_abnormal_defecation0.70068665
120MP0004215_abnormal_myocardial_fiber0.70047752
121MP0000350_abnormal_cell_proliferation0.69597198
122MP0010352_gastrointestinal_tract_polyps0.68849781
123MP0005187_abnormal_penis_morphology0.68664023
124MP0001324_abnormal_eye_pigmentation0.68520769
125MP0005389_reproductive_system_phenotype0.68264778
126MP0000858_altered_metastatic_potential0.68170876
127MP0002928_abnormal_bile_duct0.66981827
128MP0001727_abnormal_embryo_implantation0.66868056
129MP0000372_irregular_coat_pigmentation0.64772300
130MP0003119_abnormal_digestive_system0.64424231
131MP0000230_abnormal_systemic_arterial0.64268369
132MP0001730_embryonic_growth_arrest0.63119947
133MP0006072_abnormal_retinal_apoptosis0.62612449
134MP0000015_abnormal_ear_pigmentation0.62596581
135MP0005310_abnormal_salivary_gland0.62003277
136MP0008469_abnormal_protein_level0.61265957
137MP0003868_abnormal_feces_composition0.61048751
138MP0002282_abnormal_trachea_morphology0.60143158
139MP0003183_abnormal_peptide_metabolism0.59150846
140MP0001765_abnormal_ion_homeostasis0.57327195
141MP0000566_synostosis0.56567956
142MP0001666_abnormal_nutrient_absorption0.56077748
143MP0005621_abnormal_cell_physiology0.55282978
144MP0002006_tumorigenesis0.54908368
145MP0000383_abnormal_hair_follicle0.54711338
146MP0005253_abnormal_eye_physiology0.54645584
147MP0002090_abnormal_vision0.53991674
148MP0002132_abnormal_respiratory_system0.53858869
149MP0002102_abnormal_ear_morphology0.53759008
150MP0001963_abnormal_hearing_physiology0.53551119
151MP0005365_abnormal_bile_salt0.52807889
152MP0001919_abnormal_reproductive_system0.52590182
153MP0003699_abnormal_female_reproductive0.52419203
154MP0001486_abnormal_startle_reflex0.51007141
155MP0003121_genomic_imprinting0.50163209
156MP0001119_abnormal_female_reproductive0.50069408
157MP0005499_abnormal_olfactory_system0.49976830
158MP0005394_taste/olfaction_phenotype0.49976830
159MP0003724_increased_susceptibility_to0.49624424
160MP0005379_endocrine/exocrine_gland_phen0.48584071
161MP0005386_behavior/neurological_phenoty0.48513040
162MP0004924_abnormal_behavior0.48513040
163MP0005075_abnormal_melanosome_morpholog0.47425408
164MP0002229_neurodegeneration0.47100038
165MP0005380_embryogenesis_phenotype0.47006045
166MP0001672_abnormal_embryogenesis/_devel0.47006045
167MP0004043_abnormal_pH_regulation0.46485913
168MP0002080_prenatal_lethality0.46363556
169MP0009046_muscle_twitch0.45676142

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.92561642
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.92561642
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.48672228
4Abnormal respiratory epithelium morphology (HP:0012253)7.07801930
5Abnormal respiratory motile cilium morphology (HP:0005938)7.07801930
6Abnormal respiratory motile cilium physiology (HP:0012261)6.47062916
7Nasal polyposis (HP:0100582)6.24025790
8Rhinitis (HP:0012384)6.00233887
9Infertility (HP:0000789)5.28658783
10Abnormal ciliary motility (HP:0012262)5.12877837
11Abnormality of the nasal mucosa (HP:0000433)4.91299642
12Chronic bronchitis (HP:0004469)4.66383036
13Bronchitis (HP:0012387)4.47292999
14Recurrent bronchitis (HP:0002837)4.34566309
15Aplasia/Hypoplasia of the fovea (HP:0008060)4.30467602
16Hypoplasia of the fovea (HP:0007750)4.30467602
17Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.29304005
18Recurrent sinusitis (HP:0011108)4.23554364
19Male infertility (HP:0003251)4.16528476
20Bronchiectasis (HP:0002110)4.14252067
21Hypophosphatemic rickets (HP:0004912)4.13660111
22Impulsivity (HP:0100710)4.09435462
23Supernumerary spleens (HP:0009799)3.94129359
24Abnormal spermatogenesis (HP:0008669)3.89680685
25Recurrent otitis media (HP:0000403)3.79553567
26Facial hemangioma (HP:0000329)3.74842338
27Anterior segment dysgenesis (HP:0007700)3.64795160
28Abnormality of the fovea (HP:0000493)3.62919533
29Osteomalacia (HP:0002749)3.62768885
30Gaze-evoked nystagmus (HP:0000640)3.56624676
31Abnormality of abdominal situs (HP:0011620)3.41789083
32Abdominal situs inversus (HP:0003363)3.41789083
33Abnormal gallbladder physiology (HP:0012438)3.26183972
34Cholecystitis (HP:0001082)3.26183972
35Chronic otitis media (HP:0000389)3.19637319
36Fair hair (HP:0002286)3.16256099
37Malnutrition (HP:0004395)3.15507267
38Attenuation of retinal blood vessels (HP:0007843)3.15389388
39Lip pit (HP:0100267)3.13317528
40Nephronophthisis (HP:0000090)2.96892543
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.95851298
42Aplasia/Hypoplasia of the tibia (HP:0005772)2.95839286
43Congenital sensorineural hearing impairment (HP:0008527)2.93268401
44Generalized aminoaciduria (HP:0002909)2.93176852
45Chronic sinusitis (HP:0011109)2.92731614
46Heterotopia (HP:0002282)2.89541189
47Median cleft lip (HP:0000161)2.87895023
48Premature ovarian failure (HP:0008209)2.76531794
49Azoospermia (HP:0000027)2.68100331
50Capillary hemangiomas (HP:0005306)2.67516236
51Intrahepatic cholestasis (HP:0001406)2.65334166
52Conjunctival telangiectasia (HP:0000524)2.62814775
53Sensory axonal neuropathy (HP:0003390)2.60336175
54Type II lissencephaly (HP:0007260)2.60115595
55Cerebellar dysplasia (HP:0007033)2.59997640
56Short tibia (HP:0005736)2.54289588
57Lower limb hyperreflexia (HP:0002395)2.49359608
58Aplasia/Hypoplasia of the macula (HP:0008059)2.47513219
59Absent epiphyses (HP:0010577)2.46955537
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.46955537
61Hypokinesia (HP:0002375)2.44249434
62Agammaglobulinemia (HP:0004432)2.41233403
63Petechiae (HP:0000967)2.36904116
64Papillary thyroid carcinoma (HP:0002895)2.36128121
65Abnormality of the renal medulla (HP:0100957)2.29847416
66Septo-optic dysplasia (HP:0100842)2.28439846
67Decreased circulating renin level (HP:0003351)2.28193875
68Retrobulbar optic neuritis (HP:0100654)2.27797592
69Optic neuritis (HP:0100653)2.27797592
70Clubbing of toes (HP:0100760)2.27739076
71Prolonged bleeding time (HP:0003010)2.27483225
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26321102
73Tubular atrophy (HP:0000092)2.26125259
74Small epiphyses (HP:0010585)2.25978219
75Hypoplasia of the uterus (HP:0000013)2.23682796
76Aplasia/Hypoplasia affecting the retina (HP:0008061)2.23531306
77Muscle stiffness (HP:0003552)2.17571799
78Hypoglycemic coma (HP:0001325)2.15992265
79Anhidrosis (HP:0000970)2.14803611
80Enlarged penis (HP:0000040)2.14249944
81Abnormality of the ileum (HP:0001549)2.14196131
82IgM deficiency (HP:0002850)2.13192574
83Tubulointerstitial nephritis (HP:0001970)2.12468171
84Meckel diverticulum (HP:0002245)2.12315623
85Generalized hypopigmentation of hair (HP:0011358)2.11561089
86Abnormality of the renal cortex (HP:0011035)2.11357809
87Proximal tubulopathy (HP:0000114)2.11291155
88Medial flaring of the eyebrow (HP:0010747)2.11093253
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.11070280
90Squamous cell carcinoma (HP:0002860)2.08920774
91Absent thumb (HP:0009777)2.08795018
92Cellulitis (HP:0100658)2.08319218
93Bony spicule pigmentary retinopathy (HP:0007737)2.08309281
94Inflammation of the large intestine (HP:0002037)2.08300159
95Recurrent bacterial skin infections (HP:0005406)2.06875553
96Hypergonadotropic hypogonadism (HP:0000815)2.06433234
97Oligodactyly (hands) (HP:0001180)2.05526102
98Dysmetric saccades (HP:0000641)2.05231194
99Recurrent abscess formation (HP:0002722)2.04963974
100Pustule (HP:0200039)2.04497269
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04086440
102Pancreatic cysts (HP:0001737)2.03967372
103Abnormality of the fingertips (HP:0001211)2.03770721
104Clumsiness (HP:0002312)2.03320891
105Abnormality of DNA repair (HP:0003254)2.03005395
106Decreased central vision (HP:0007663)2.02154891
107Dysdiadochokinesis (HP:0002075)2.01777594
108Duplicated collecting system (HP:0000081)2.01104698
109Recurrent viral infections (HP:0004429)2.00590300
110Apathy (HP:0000741)1.99935911
111Gastrointestinal inflammation (HP:0004386)1.97432555
112Abnormality of the renal collecting system (HP:0004742)1.95766392
113Truncal obesity (HP:0001956)1.95727384
114Ectopic kidney (HP:0000086)1.92461661
115Abnormal rod and cone electroretinograms (HP:0008323)1.92049988
116Gonadal dysgenesis (HP:0000133)1.91961298
117Panhypogammaglobulinemia (HP:0003139)1.90767896
118Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.89332777
119Flattened epiphyses (HP:0003071)1.89100430
120Stomatitis (HP:0010280)1.89012694
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.88216361
122Myositis (HP:0100614)1.87638104
123Optic nerve hypoplasia (HP:0000609)1.86902420
124Metaphyseal irregularity (HP:0003025)1.85932977
125Prominent nose (HP:0000448)1.85505625
126Aplasia/hypoplasia of the uterus (HP:0008684)1.85330317
127Abnormal platelet volume (HP:0011876)1.84948143
128Chromsome breakage (HP:0040012)1.83130361
129Colitis (HP:0002583)1.82343519
130Diminished motivation (HP:0000745)1.81696179
131Photophobia (HP:0000613)1.79000108
132Absent septum pellucidum (HP:0001331)1.78170696
133Abnormality of lateral ventricle (HP:0030047)1.77598396
134Orchitis (HP:0100796)1.77390910
135Abnormal delayed hypersensitivity skin test (HP:0002963)1.76811053
136Recurrent fungal infections (HP:0002841)1.76574750
137Tubulointerstitial abnormality (HP:0001969)1.76459723
138Meningitis (HP:0001287)1.73940085
139Bell-shaped thorax (HP:0001591)1.67986510
140Abnormality of chromosome stability (HP:0003220)1.67874636
141Severe combined immunodeficiency (HP:0004430)1.66122140
142Abnormality of midbrain morphology (HP:0002418)1.66046071
143Molar tooth sign on MRI (HP:0002419)1.66046071
144T lymphocytopenia (HP:0005403)1.64577546
145Personality changes (HP:0000751)1.64504461
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.64223218
147Abnormality of T cells (HP:0002843)1.64083482
148Papilloma (HP:0012740)1.62438747
149Verrucae (HP:0200043)1.62438747
150Abnormality of T cell number (HP:0011839)1.62398893
151Sloping forehead (HP:0000340)1.61865128
152Combined immunodeficiency (HP:0005387)1.61664223
153Abnormal number of erythroid precursors (HP:0012131)1.60394299
154Type 2 muscle fiber atrophy (HP:0003554)1.59470739
155Gonadotropin excess (HP:0000837)1.59405626
156Entropion (HP:0000621)1.59382431
157Lymphopenia (HP:0001888)1.56930739
158Abnormal biliary tract physiology (HP:0012439)1.55482273
159Bile duct proliferation (HP:0001408)1.55482273
160Thyroiditis (HP:0100646)1.52976619
161Spastic tetraparesis (HP:0001285)1.52191691
162Acute myeloid leukemia (HP:0004808)1.51463397
163Increased mean platelet volume (HP:0011877)1.51077629
164Tubulointerstitial fibrosis (HP:0005576)1.50672207
165Abnormality of T cell physiology (HP:0011840)1.50583996
166Muscle fiber atrophy (HP:0100295)1.48353256
167Autoimmune thrombocytopenia (HP:0001973)1.48069649
168Congenital primary aphakia (HP:0007707)1.47417190
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.46593133
170Abnormality of the preputium (HP:0100587)1.45327904
171Poikilocytosis (HP:0004447)1.44988640
172Abnormality of the anterior horn cell (HP:0006802)1.43991302
173Degeneration of anterior horn cells (HP:0002398)1.43991302
174Choroideremia (HP:0001139)1.43124579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.54075962
2PDK45.54075962
3MAP3K95.39729300
4MAP3K134.99572256
5ARAF4.63728203
6TESK14.30266729
7PRKD33.72855874
8FRK3.49823348
9PINK13.45635036
10PNCK3.45129151
11MAP4K13.36681233
12PDK23.26096497
13TAOK33.03124601
14EEF2K2.68079535
15EIF2AK12.44334602
16ICK2.40386477
17ACVR1B2.33573194
18NEK62.27925263
19NEK22.21119580
20BRAF2.14191417
21MOS2.11681981
22CDC71.97571224
23BMPR1B1.84798142
24CAMK1G1.69096860
25MELK1.68720648
26CDK121.68704880
27KSR21.58614290
28MAP3K101.56037344
29STK31.55657270
30CDK91.43336041
31PLK41.41318477
32EIF2AK31.39055744
33STK101.38642453
34TXK1.36460880
35PRKCI1.36233756
36TLK11.35609066
37RAF11.32875940
38RIPK41.31056369
39MAP3K51.28774497
40MAP2K31.25834802
41DYRK31.25351931
42MET1.22022904
43MAP3K141.19901804
44MST41.15794131
45AURKA1.15243785
46SYK1.11086243
47EIF2AK21.10214995
48PTK2B1.09173628
49SIK21.09149581
50TTK1.09094208
51STK381.05401398
52ZAP701.02310363
53LATS20.98992690
54TNIK0.97171481
55KSR10.96884676
56GRK60.95053311
57TNK20.94895565
58PIM10.94279097
59BTK0.92900355
60SCYL20.92704092
61CDK70.91289050
62PDK10.87686126
63TYK20.86929158
64ADRBK20.81797830
65DYRK1B0.81375926
66CCNB10.81127275
67CDK40.79982264
68TGFBR10.79900545
69ATR0.79374496
70CHEK20.78987762
71CHEK10.76215272
72PASK0.74840242
73MARK30.74639405
74MAP3K10.72590067
75BLK0.71385247
76CSNK1G10.70179037
77BRSK10.69359914
78FES0.68879542
79PKN10.68742903
80TRIB30.68625686
81PIM20.67121559
82ITK0.66916957
83NLK0.66882921
84MAP2K60.66413232
85MYLK0.65978436
86MAPKAPK30.65948301
87AKT30.65044669
88CSF1R0.63452281
89NTRK20.63316203
90TIE10.62750309
91PRKCQ0.62639652
92TRIM280.62470454
93WEE10.62396135
94JAK10.62079273
95IRAK10.61773266
96STK240.61734753
97ATM0.60982960
98VRK10.59707261
99HCK0.58722684
100IKBKB0.58417351
101JAK30.57440005
102OBSCN0.57324860
103PRKG10.57064979
104CHUK0.56550791
105STK390.55409434
106CLK10.55086429
107TEC0.54754891
108LMTK20.51363580
109CSNK1D0.50865349
110SRPK10.48946041
111PLK10.48552685
112TBK10.47216924
113BRD40.47078084
114CSNK1G30.46645583
115STK38L0.46484804
116LCK0.45829741
117RPS6KB10.45602897
118CSK0.45141421
119LYN0.44099653
120NUAK10.44074926
121WNK40.44034634
122TRPM70.43920381
123STK40.43747702
124TSSK60.43566280
125RPS6KA50.43336485
126AURKB0.42707346
127CSNK1A1L0.42436108
128IKBKE0.41939805
129GRK10.40832131
130BRSK20.38969201
131PDPK10.38924804
132ERN10.38721994
133NTRK30.38620430
134CDK60.38602462
135MAP2K70.38078668
136CDK30.36197097
137RPS6KA40.35915507
138MAP3K40.35897850
139MAPK130.35897031
140ALK0.35662668
141WNK10.35286493
142MAP2K10.34766608
143EPHA40.34686520
144IRAK20.34171222
145ZAK0.33862288
146CDK20.32876613
147MTOR0.32814070
148RET0.30955970
149OXSR10.30129749
150PBK0.29852185
151INSRR0.29750322
152PRKAA10.29440532
153BUB10.29326554
154CDK80.28431369
155MAPK120.27328733
156CDK190.26677047
157SIK10.25674559
158MARK20.24835021
159PAK10.24260891
160NME20.24228279
161MAPKAPK20.23736255
162PLK30.23387733
163MAP3K80.22635336
164LRRK20.22178099

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.25075675
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.53208432
3Olfactory transduction_Homo sapiens_hsa047403.02962143
4Primary immunodeficiency_Homo sapiens_hsa053402.92446444
5Ovarian steroidogenesis_Homo sapiens_hsa049132.75488976
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.53786131
7B cell receptor signaling pathway_Homo sapiens_hsa046622.46857070
8Caffeine metabolism_Homo sapiens_hsa002322.43127756
9RNA transport_Homo sapiens_hsa030132.33383759
10Antigen processing and presentation_Homo sapiens_hsa046122.29524061
11Circadian rhythm_Homo sapiens_hsa047102.25227214
12Fanconi anemia pathway_Homo sapiens_hsa034602.24270480
13ABC transporters_Homo sapiens_hsa020102.16649803
14NF-kappa B signaling pathway_Homo sapiens_hsa040641.94589879
15Basal transcription factors_Homo sapiens_hsa030221.94056805
16Fatty acid biosynthesis_Homo sapiens_hsa000611.93259933
17DNA replication_Homo sapiens_hsa030301.92754011
18Phototransduction_Homo sapiens_hsa047441.89738357
19Measles_Homo sapiens_hsa051621.86356896
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84115059
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.73467229
22T cell receptor signaling pathway_Homo sapiens_hsa046601.72298271
23Hematopoietic cell lineage_Homo sapiens_hsa046401.65749263
24mRNA surveillance pathway_Homo sapiens_hsa030151.62880258
25Cell cycle_Homo sapiens_hsa041101.61716697
26Nitrogen metabolism_Homo sapiens_hsa009101.59136885
27Gap junction_Homo sapiens_hsa045401.55277553
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52863836
29Homologous recombination_Homo sapiens_hsa034401.51759275
30RNA polymerase_Homo sapiens_hsa030201.50899820
31Oocyte meiosis_Homo sapiens_hsa041141.50246001
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40212760
33Alcoholism_Homo sapiens_hsa050341.39063664
34p53 signaling pathway_Homo sapiens_hsa041151.37895671
35Legionellosis_Homo sapiens_hsa051341.34886797
36Epstein-Barr virus infection_Homo sapiens_hsa051691.33688443
37Dorso-ventral axis formation_Homo sapiens_hsa043201.32060003
38Osteoclast differentiation_Homo sapiens_hsa043801.30475736
39Non-homologous end-joining_Homo sapiens_hsa034501.27517278
40Herpes simplex infection_Homo sapiens_hsa051681.25634113
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25328685
42Glucagon signaling pathway_Homo sapiens_hsa049221.25085869
43Chemical carcinogenesis_Homo sapiens_hsa052041.23052918
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22619669
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.22181552
46Regulation of autophagy_Homo sapiens_hsa041401.21038491
47Base excision repair_Homo sapiens_hsa034101.19704223
48Systemic lupus erythematosus_Homo sapiens_hsa053221.18909024
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18838321
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18766693
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17919534
52Butanoate metabolism_Homo sapiens_hsa006501.14114119
53Serotonergic synapse_Homo sapiens_hsa047261.13755820
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.12785052
55Mismatch repair_Homo sapiens_hsa034301.12463722
56Bile secretion_Homo sapiens_hsa049761.11289351
57RNA degradation_Homo sapiens_hsa030181.10315470
58Jak-STAT signaling pathway_Homo sapiens_hsa046301.07809048
59Nucleotide excision repair_Homo sapiens_hsa034201.07696590
60Toxoplasmosis_Homo sapiens_hsa051451.06483849
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05446635
62Viral carcinogenesis_Homo sapiens_hsa052031.04256372
63Influenza A_Homo sapiens_hsa051641.03683608
64Allograft rejection_Homo sapiens_hsa053301.03285741
65Inositol phosphate metabolism_Homo sapiens_hsa005621.03151457
66Pyrimidine metabolism_Homo sapiens_hsa002401.02383065
67Leishmaniasis_Homo sapiens_hsa051401.01062642
68Glycerophospholipid metabolism_Homo sapiens_hsa005640.99998411
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99005570
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98401882
71Purine metabolism_Homo sapiens_hsa002300.96324313
72Pentose phosphate pathway_Homo sapiens_hsa000300.94579870
73FoxO signaling pathway_Homo sapiens_hsa040680.92503022
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92300728
75Spliceosome_Homo sapiens_hsa030400.90741748
76Chronic myeloid leukemia_Homo sapiens_hsa052200.90451207
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.89877323
78Acute myeloid leukemia_Homo sapiens_hsa052210.89439723
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87074758
80Long-term depression_Homo sapiens_hsa047300.86886924
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86538472
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86325808
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80562078
84Apoptosis_Homo sapiens_hsa042100.79639263
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.79392376
86Graft-versus-host disease_Homo sapiens_hsa053320.79122942
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79102736
88Selenocompound metabolism_Homo sapiens_hsa004500.78478581
89Tryptophan metabolism_Homo sapiens_hsa003800.77890506
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.77009709
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76508061
92HTLV-I infection_Homo sapiens_hsa051660.74793005
93Morphine addiction_Homo sapiens_hsa050320.74785853
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74763185
95GABAergic synapse_Homo sapiens_hsa047270.73280735
96One carbon pool by folate_Homo sapiens_hsa006700.72720228
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72718898
98Pyruvate metabolism_Homo sapiens_hsa006200.71722548
99Arginine biosynthesis_Homo sapiens_hsa002200.71039381
100Retinol metabolism_Homo sapiens_hsa008300.70859525
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70465655
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70433317
103VEGF signaling pathway_Homo sapiens_hsa043700.70308332
104Sulfur relay system_Homo sapiens_hsa041220.70115724
105Propanoate metabolism_Homo sapiens_hsa006400.69996798
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68832551
107Calcium signaling pathway_Homo sapiens_hsa040200.68665524
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.67077170
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66834463
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65652771
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65645213
112Glycerolipid metabolism_Homo sapiens_hsa005610.65069077
113Arachidonic acid metabolism_Homo sapiens_hsa005900.64943910
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64661671
115* Taste transduction_Homo sapiens_hsa047420.64391295
116Circadian entrainment_Homo sapiens_hsa047130.64232691
117Nicotine addiction_Homo sapiens_hsa050330.63927588
118Amphetamine addiction_Homo sapiens_hsa050310.63744003
119Hepatitis B_Homo sapiens_hsa051610.62872937
120Viral myocarditis_Homo sapiens_hsa054160.61616304
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60849923
122Tuberculosis_Homo sapiens_hsa051520.60365482
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60225633
124beta-Alanine metabolism_Homo sapiens_hsa004100.58116924
125Oxytocin signaling pathway_Homo sapiens_hsa049210.57105775
126Platelet activation_Homo sapiens_hsa046110.57008473
127Small cell lung cancer_Homo sapiens_hsa052220.56859715
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54146162
129Insulin secretion_Homo sapiens_hsa049110.53521360
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53015434
131Arginine and proline metabolism_Homo sapiens_hsa003300.52407663
132TGF-beta signaling pathway_Homo sapiens_hsa043500.52048707
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52034027
134Mineral absorption_Homo sapiens_hsa049780.51110511
135Salivary secretion_Homo sapiens_hsa049700.50005189
136Estrogen signaling pathway_Homo sapiens_hsa049150.49972560
137Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49863409
138Linoleic acid metabolism_Homo sapiens_hsa005910.49850599
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49606259
140Asthma_Homo sapiens_hsa053100.49232594
141Histidine metabolism_Homo sapiens_hsa003400.49040569
142N-Glycan biosynthesis_Homo sapiens_hsa005100.48280364
143Long-term potentiation_Homo sapiens_hsa047200.47689967
144Type I diabetes mellitus_Homo sapiens_hsa049400.47474849
145Phagosome_Homo sapiens_hsa041450.47209991
146Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47056882
147Primary bile acid biosynthesis_Homo sapiens_hsa001200.46117989
148Malaria_Homo sapiens_hsa051440.45750210
149Cysteine and methionine metabolism_Homo sapiens_hsa002700.45393240
150TNF signaling pathway_Homo sapiens_hsa046680.42914535
151Complement and coagulation cascades_Homo sapiens_hsa046100.42633850
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41165854
153Autoimmune thyroid disease_Homo sapiens_hsa053200.41044198
154Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40766924
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40544600
156Shigellosis_Homo sapiens_hsa051310.40165232
157Pancreatic cancer_Homo sapiens_hsa052120.40068377
158Chemokine signaling pathway_Homo sapiens_hsa040620.36516697
159mTOR signaling pathway_Homo sapiens_hsa041500.36393915
160Ether lipid metabolism_Homo sapiens_hsa005650.30220945
161Glutathione metabolism_Homo sapiens_hsa004800.30109329
162cAMP signaling pathway_Homo sapiens_hsa040240.29202262
163Drug metabolism - other enzymes_Homo sapiens_hsa009830.26867673
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22297581
165Folate biosynthesis_Homo sapiens_hsa007900.22185774
166Fatty acid elongation_Homo sapiens_hsa000620.22088188

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »