ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of erythrocyte differentiation (GO:0045647)	4.34043022
2	regulation of ARF GTPase activity (GO:0032312)	4.10634463
3	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	4.05538310
4	mannose metabolic process (GO:0006013)	4.04761815
5	regulation of cholesterol homeostasis (GO:2000188)	3.64049145
6	regulation of apoptotic cell clearance (GO:2000425)	3.64029283
7	insulin-like growth factor receptor signaling pathway (GO:0048009)	3.60971039
8	regulation of histone H3-K27 methylation (GO:0061085)	3.40649018
9	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.38458038
10	histone H3-K9 demethylation (GO:0033169)	3.38238267
11	positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:00360	3.27581686
12	semaphorin-plexin signaling pathway (GO:0071526)	3.26114654
13	lung epithelium development (GO:0060428)	3.17342015
14	cell-substrate junction assembly (GO:0007044)	3.12876239
15	cellular response to epidermal growth factor stimulus (GO:0071364)	3.10901123
16	regulation of ARF protein signal transduction (GO:0032012)	3.07658670
17	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	3.06649843
18	adherens junction assembly (GO:0034333)	3.06387571
19	regulation of extracellular matrix disassembly (GO:0010715)	3.05289288
20	negative regulation of fatty acid transport (GO:2000192)	3.05266898
21	cell-substrate adherens junction assembly (GO:0007045)	3.03462820
22	focal adhesion assembly (GO:0048041)	3.03462820
23	positive regulation of synapse maturation (GO:0090129)	2.95823727
24	negative regulation of cell size (GO:0045792)	2.90229307
25	atrioventricular valve morphogenesis (GO:0003181)	2.90066172
26	hemidesmosome assembly (GO:0031581)	2.86840876
27	protein carboxylation (GO:0018214)	2.82551790
28	peptidyl-glutamic acid carboxylation (GO:0017187)	2.82551790
29	embryonic process involved in female pregnancy (GO:0060136)	2.82069960
30	histone H4 deacetylation (GO:0070933)	2.81098532
31	regulation of extracellular matrix organization (GO:1903053)	2.78422215
32	response to epidermal growth factor (GO:0070849)	2.77814068
33	negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	2.77744356
34	cell-cell junction maintenance (GO:0045217)	2.74382031
35	negative regulation of myotube differentiation (GO:0010832)	2.72657188
36	positive regulation of extracellular matrix organization (GO:1903055)	2.69419536
37	basement membrane organization (GO:0071711)	2.69118455
38	activation of JUN kinase activity (GO:0007257)	2.68802280
39	planar cell polarity pathway involved in neural tube closure (GO:0090179)	2.67930693
40	neural tube development (GO:0021915)	2.67624009
41	thymic T cell selection (GO:0045061)	2.67422632
42	histone H3 deacetylation (GO:0070932)	2.62661973
43	histone lysine demethylation (GO:0070076)	2.61350873
44	protein-lipid complex assembly (GO:0065005)	2.58861980
45	cell volume homeostasis (GO:0006884)	2.57907451
46	response to muramyl dipeptide (GO:0032495)	2.57127848
47	apoptotic process involved in morphogenesis (GO:0060561)	2.55120739
48	positive regulation of histone deacetylation (GO:0031065)	2.54922891
49	cerebellar granule cell differentiation (GO:0021707)	2.54518313
50	plasma lipoprotein particle assembly (GO:0034377)	2.50956707
51	positive regulation of CREB transcription factor activity (GO:0032793)	2.49341012
52	histone H3-K36 demethylation (GO:0070544)	2.49106064
53	histone demethylation (GO:0016577)	2.47997178
54	regulation of response to osmotic stress (GO:0047484)	2.46323429
55	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.46164969
56	response to laminar fluid shear stress (GO:0034616)	2.44597867
57	regulation of synapse maturation (GO:0090128)	2.43323682
58	heart valve formation (GO:0003188)	2.41519618
59	pinocytosis (GO:0006907)	2.41418922
60	response to fluid shear stress (GO:0034405)	2.40198850
61	endothelial cell chemotaxis (GO:0035767)	2.40157152
62	negative regulation of fibrinolysis (GO:0051918)	2.36156796
63	positive thymic T cell selection (GO:0045059)	2.35562116
64	low-density lipoprotein particle clearance (GO:0034383)	2.34429193
65	histone H3-K4 trimethylation (GO:0080182)	2.33602637
66	regulation of NFAT protein import into nucleus (GO:0051532)	2.31617930
67	positive regulation of Rap GTPase activity (GO:0032854)	2.31044669
68	activation of Rac GTPase activity (GO:0032863)	2.29723877
69	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.28782667
70	intestinal cholesterol absorption (GO:0030299)	2.27954601
71	stress granule assembly (GO:0034063)	2.25356919
72	stress fiber assembly (GO:0043149)	2.24902155
73	regulation of cholesterol biosynthetic process (GO:0045540)	2.24285420
74	regulation of early endosome to late endosome transport (GO:2000641)	2.23528257
75	receptor catabolic process (GO:0032801)	2.23236871
76	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.22264123
77	protein targeting to plasma membrane (GO:0072661)	2.22130157
78	cell migration in hindbrain (GO:0021535)	2.20320060
79	osteoblast development (GO:0002076)	2.17548758
80	regulation of nucleobase-containing compound transport (GO:0032239)	2.16214102
81	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	2.15693676
82	positive regulation of phagocytosis (GO:0050766)	2.14311718
83	regulation of p38MAPK cascade (GO:1900744)	2.13935815
84	proline metabolic process (GO:0006560)	2.13689898
85	regulation of somitogenesis (GO:0014807)	2.13548517
86	protein demethylation (GO:0006482)	2.09252206
87	protein dealkylation (GO:0008214)	2.09252206
88	definitive hemopoiesis (GO:0060216)	2.09131561
89	epithelial cell fate commitment (GO:0072148)	2.09116108
90	response to vitamin A (GO:0033189)	2.08982169
91	regulation of fatty acid beta-oxidation (GO:0031998)	2.08783959
92	negative regulation of osteoblast differentiation (GO:0045668)	2.08522203
93	regulation of glucose import in response to insulin stimulus (GO:2001273)	2.07916523
94	regulation of RNA export from nucleus (GO:0046831)	2.07835854
95	histone H3-K4 methylation (GO:0051568)	2.07363524
96	coronary vasculature morphogenesis (GO:0060977)	2.05931298
97	venous blood vessel morphogenesis (GO:0048845)	2.05413517
98	nephron tubule morphogenesis (GO:0072078)	2.05212042
99	nephron epithelium morphogenesis (GO:0072088)	2.05212042
100	activation of MAPKKK activity (GO:0000185)	2.05008531

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.38882305
2	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	3.21955822
3	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.06375113
4	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.95904103
5	LXR_22292898_ChIP-Seq_THP-1_Human	2.86558167
6	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.67854465
7	MYC_22102868_ChIP-Seq_BL_Human	2.62111370
8	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.57888045
9	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.56858168
10	TCF7_22412390_ChIP-Seq_EML_Mouse	2.52928826
11	KDM2B_26808549_Chip-Seq_DND41_Human	2.46141148
12	VDR_21846776_ChIP-Seq_THP-1_Human	2.43381030
13	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.37995543
14	KDM2B_26808549_Chip-Seq_K562_Human	2.34622902
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.33547815
16	DROSHA_22980978_ChIP-Seq_HELA_Human	2.21769138
17	RACK7_27058665_Chip-Seq_MCF-7_Human	2.01996007
18	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	2.00076976
19	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.97685822
20	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.96758637
21	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.92209765
22	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.87367986
23	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.84887738
24	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.80102910
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.77184941
26	P68_20966046_ChIP-Seq_HELA_Human	1.69514015
27	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.69457556
28	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.68903092
29	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.65547920
30	SMC4_20622854_ChIP-Seq_HELA_Human	1.62716628
31	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.62048970
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.61541332
33	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.57037417
34	CREB1_26743006_Chip-Seq_LNCaP_Human	1.55377845
35	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.53536969
36	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.51987574
37	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.50574091
38	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.48653268
39	GATA1_19941826_ChIP-Seq_K562_Human	1.46088803
40	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.43969607
41	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.43667062
42	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.43439127
43	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.43147850
44	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.41472545
45	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.41404453
46	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.41303494
47	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.40151900
48	VDR_24763502_ChIP-Seq_THP-1_Human	1.39371666
49	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.38955788
50	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.38736998
51	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.38200671
52	ZNF263_19887448_ChIP-Seq_K562_Human	1.34447270
53	CTCF_27219007_Chip-Seq_Bcells_Human	1.34249925
54	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.31244321
55	MAF_26560356_Chip-Seq_TH1_Human	1.31233529
56	NCOR1_26117541_ChIP-Seq_K562_Human	1.31182427
57	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.31082812
58	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.30427538
59	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.28073670
60	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.26704823
61	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.26141131
62	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.23658764
63	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.23572583
64	TP53_22127205_ChIP-Seq_IMR90_Human	1.22847464
65	CLOCK_20551151_ChIP-Seq_293T_Human	1.22351119
66	MAF_26560356_Chip-Seq_TH2_Human	1.22041928
67	UTX_26944678_Chip-Seq_JUKART_Human	1.21733813
68	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.17430274
69	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16832901
70	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.16653839
71	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.14857313
72	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.14805688
73	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.13809732
74	SCL_19346495_ChIP-Seq_HPC-7_Human	1.13786598
75	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.13341876
76	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.12922117
77	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.12821721
78	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.11443007
79	TP63_22573176_ChIP-Seq_HFKS_Human	1.10309319
80	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.10286484
81	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.10159421
82	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09405114
83	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.09389872
84	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.08964972
85	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.06169798
86	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.06136511
87	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.03211199
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.03004498
89	SPI1_23127762_ChIP-Seq_K562_Human	1.02999631
90	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.01432683
91	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.99106111
92	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.99106111
93	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.99006572
94	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.98769937
95	BCOR_27268052_Chip-Seq_Bcells_Human	0.98437210
96	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.95030642
97	OCT4_19829295_ChIP-Seq_ESCs_Human	0.93939750
98	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.93914197
99	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.93058030
100	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.92706397

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003705_abnormal_hypodermis_morpholog	4.39210033
2	MP0003172_abnormal_lysosome_physiology	3.87198590
3	MP0008438_abnormal_cutaneous_collagen	3.73157220
4	MP0005076_abnormal_cell_differentiation	3.23539769
5	MP0005409_darkened_coat_color	2.97884117
6	MP0002249_abnormal_larynx_morphology	2.79449008
7	MP0005360_urolithiasis	2.73304410
8	MP0003279_aneurysm	2.35958844
9	MP0001348_abnormal_lacrimal_gland	2.33946132
10	MP0000678_abnormal_parathyroid_gland	2.33046219
11	MP0001849_ear_inflammation	2.30220974
12	MP0001958_emphysema	2.29567479
13	MP0005058_abnormal_lysosome_morphology	2.28743625
14	MP0008260_abnormal_autophagy	2.14076505
15	MP0005451_abnormal_body_composition	2.09834951
16	MP0003566_abnormal_cell_adhesion	2.03607829
17	MP0000751_myopathy	2.02468270
18	MP0009384_cardiac_valve_regurgitation	1.99764248
19	MP0003091_abnormal_cell_migration	1.81851687
20	MP0000566_synostosis	1.78998344
21	MP0005275_abnormal_skin_tensile	1.78860108
22	MP0003879_abnormal_hair_cell	1.72764079
23	MP0009278_abnormal_bone_marrow	1.69943837
24	MP0002933_joint_inflammation	1.66972312
25	MP0002089_abnormal_postnatal_growth/wei	1.65013919
26	MP0004858_abnormal_nervous_system	1.63339967
27	MP0003045_fibrosis	1.56543211
28	MP0004272_abnormal_basement_membrane	1.55386189
29	MP0006138_congestive_heart_failure	1.52554431
30	MP0000003_abnormal_adipose_tissue	1.52441621
31	MP0005670_abnormal_white_adipose	1.49472727
32	MP0000767_abnormal_smooth_muscle	1.38864714
33	MP0005375_adipose_tissue_phenotype	1.37084582
34	MP0000733_abnormal_muscle_development	1.36400469
35	MP0005666_abnormal_adipose_tissue	1.35186166
36	MP0002060_abnormal_skin_morphology	1.31788715
37	MP0003436_decreased_susceptibility_to	1.31368143
38	MP0004185_abnormal_adipocyte_glucose	1.27377427
39	MP0004859_abnormal_synaptic_plasticity	1.23873705
40	MP0003453_abnormal_keratinocyte_physiol	1.22783014
41	MP0005257_abnormal_intraocular_pressure	1.22360992
42	MP0000013_abnormal_adipose_tissue	1.22360090
43	MP0001915_intracranial_hemorrhage	1.19139352
44	MP0003329_amyloid_beta_deposits	1.18248732
45	MP0005503_abnormal_tendon_morphology	1.15688182
46	MP0004381_abnormal_hair_follicle	1.14463030
47	MP0003115_abnormal_respiratory_system	1.10508797
48	MP0009840_abnormal_foam_cell	1.09878646
49	MP0005023_abnormal_wound_healing	1.09166278
50	MP0010630_abnormal_cardiac_muscle	1.06270553
51	MP0010368_abnormal_lymphatic_system	1.03869352
52	MP0003300_gastrointestinal_ulcer	1.00353745
53	MP0009780_abnormal_chondrocyte_physiolo	0.99635608
54	MP0002998_abnormal_bone_remodeling	0.99176467
55	MP0002108_abnormal_muscle_morphology	0.98528255
56	MP0004947_skin_inflammation	0.98203710
57	MP0000747_muscle_weakness	0.97745841
58	MP0001299_abnormal_eye_distance/	0.96757260
59	MP0004087_abnormal_muscle_fiber	0.96702795
60	MP0000759_abnormal_skeletal_muscle	0.95853570
61	MP0008004_abnormal_stomach_pH	0.95462362
62	MP0000681_abnormal_thyroid_gland	0.94072542
63	MP0008569_lethality_at_weaning	0.92648812
64	MP0002896_abnormal_bone_mineralization	0.92065029
65	MP0005083_abnormal_biliary_tract	0.91072353
66	MP0003656_abnormal_erythrocyte_physiolo	0.90464562
67	MP0002822_catalepsy	0.89778219
68	MP0001270_distended_abdomen	0.85464370
69	MP0005377_hearing/vestibular/ear_phenot	0.85390231
70	MP0003878_abnormal_ear_physiology	0.85390231
71	MP0005621_abnormal_cell_physiology	0.85292567
72	MP0002925_abnormal_cardiovascular_devel	0.84606681
73	MP0008961_abnormal_basal_metabolism	0.82968603
74	MP0005508_abnormal_skeleton_morphology	0.80957680
75	MP0003303_peritoneal_inflammation	0.80236053
76	MP0002166_altered_tumor_susceptibility	0.80171701
77	MP0001502_abnormal_circadian_rhythm	0.79835900
78	MP0010329_abnormal_lipoprotein_level	0.79723339
79	MP0001545_abnormal_hematopoietic_system	0.78437893
80	MP0005397_hematopoietic_system_phenotyp	0.78437893
81	MP0003763_abnormal_thymus_physiology	0.77187027
82	MP0002970_abnormal_white_adipose	0.76410624
83	MP0002128_abnormal_blood_circulation	0.75981555
84	MP0004130_abnormal_muscle_cell	0.74913328
85	MP0002396_abnormal_hematopoietic_system	0.74518717
86	MP0003942_abnormal_urinary_system	0.74349641
87	MP0001851_eye_inflammation	0.74232259
88	MP0003385_abnormal_body_wall	0.74011246
89	MP0002932_abnormal_joint_morphology	0.72997275
90	MP0004036_abnormal_muscle_relaxation	0.72971687
91	MP0009115_abnormal_fat_cell	0.71070551
92	MP0001661_extended_life_span	0.70825321
93	MP0001614_abnormal_blood_vessel	0.70669342
94	MP0003283_abnormal_digestive_organ	0.70202148
95	MP0003690_abnormal_glial_cell	0.69502450
96	MP0002114_abnormal_axial_skeleton	0.69234375
97	MP0002269_muscular_atrophy	0.69205658
98	MP0009931_abnormal_skin_appearance	0.68819804
99	MP0004808_abnormal_hematopoietic_stem	0.67997258
100	MP0004084_abnormal_cardiac_muscle	0.67542859

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Obstructive sleep apnea (HP:0002870)	4.39421667
2	Cerebral aneurysm (HP:0004944)	4.20327786
3	Broad face (HP:0000283)	3.92088947
4	Protrusio acetabuli (HP:0003179)	3.65329904
5	Cervical subluxation (HP:0003308)	3.28118425
6	Deep venous thrombosis (HP:0002625)	3.22326103
7	Hyperacusis (HP:0010780)	2.94392987
8	Abnormality of the fingertips (HP:0001211)	2.88388701
9	Hemorrhage of the eye (HP:0011885)	2.81708831
10	Premature rupture of membranes (HP:0001788)	2.72594257
11	Ulnar bowing (HP:0003031)	2.70008804
12	Thin bony cortex (HP:0002753)	2.62874089
13	Biconcave vertebral bodies (HP:0004586)	2.61829070
14	Shallow orbits (HP:0000586)	2.56352934
15	Aortic regurgitation (HP:0001659)	2.48432701
16	Atrophic scars (HP:0001075)	2.48314468
17	Stridor (HP:0010307)	2.47145557
18	Aneurysm (HP:0002617)	2.47040149
19	Disproportionate tall stature (HP:0001519)	2.41351701
20	Increased connective tissue (HP:0009025)	2.39299378
21	Bronchomalacia (HP:0002780)	2.38321860
22	Dislocated radial head (HP:0003083)	2.32895191
23	Flared iliac wings (HP:0002869)	2.30951089
24	Broad palm (HP:0001169)	2.26723945
25	Mitral regurgitation (HP:0001653)	2.25589527
26	Aortic aneurysm (HP:0004942)	2.23196825
27	Mitral valve prolapse (HP:0001634)	2.20232767
28	Abnormality of the radial head (HP:0003995)	2.16908180
29	Flat acetabular roof (HP:0003180)	2.16593577
30	Joint hemorrhage (HP:0005261)	2.16482098
31	Neonatal short-limb short stature (HP:0008921)	2.14457546
32	Lymphangioma (HP:0100764)	2.12041243
33	Long eyelashes (HP:0000527)	2.11807608
34	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	2.09724785
35	Dilatation of the ascending aorta (HP:0005111)	2.08627049
36	Fragile skin (HP:0001030)	2.06005746
37	J-shaped sella turcica (HP:0002680)	2.03801298
38	Pointed chin (HP:0000307)	1.99502685
39	Abnormality of the thoracic spine (HP:0100711)	1.95497939
40	Atelectasis (HP:0100750)	1.94998804
41	Heterotopia (HP:0002282)	1.93691647
42	Thin ribs (HP:0000883)	1.92668231
43	Distal lower limb amyotrophy (HP:0008944)	1.92005344
44	Colitis (HP:0002583)	1.91785700
45	Bladder diverticulum (HP:0000015)	1.90819136
46	Vertebral arch anomaly (HP:0008438)	1.89838120
47	Distal upper limb amyotrophy (HP:0007149)	1.89236195
48	Upper limb amyotrophy (HP:0009129)	1.89236195
49	Joint laxity (HP:0001388)	1.88397039
50	Aortic dissection (HP:0002647)	1.88168842
51	Asymmetry of the thorax (HP:0001555)	1.84276430
52	Advanced eruption of teeth (HP:0006288)	1.84134698
53	Wormian bones (HP:0002645)	1.82885609
54	Mild short stature (HP:0003502)	1.82726484
55	Increased variability in muscle fiber diameter (HP:0003557)	1.81566495
56	Blue sclerae (HP:0000592)	1.81474331
57	Spinal canal stenosis (HP:0003416)	1.80059661
58	Reticulocytosis (HP:0001923)	1.79063028
59	Renovascular hypertension (HP:0100817)	1.76223512
60	Insomnia (HP:0100785)	1.75451636
61	Hypercholesterolemia (HP:0003124)	1.74832027
62	Neoplasm of the heart (HP:0100544)	1.74313987
63	Urinary glycosaminoglycan excretion (HP:0003541)	1.74185143
64	Mucopolysacchariduria (HP:0008155)	1.74185143
65	Broad metatarsal (HP:0001783)	1.73556086
66	Natal tooth (HP:0000695)	1.71059711
67	Ankyloglossia (HP:0010296)	1.70579872
68	Epiphyseal dysplasia (HP:0002656)	1.69976182
69	Joint stiffness (HP:0001387)	1.69884437
70	Narrow palate (HP:0000189)	1.69337678
71	Laryngomalacia (HP:0001601)	1.68717574
72	Nuclear cataract (HP:0100018)	1.67287542
73	Round ear (HP:0100830)	1.66685955
74	Arnold-Chiari malformation (HP:0002308)	1.65975582
75	Bowel incontinence (HP:0002607)	1.64698613
76	Mildly elevated creatine phosphokinase (HP:0008180)	1.62967577
77	Abnormality of the humeroradial joint (HP:0100744)	1.62107213
78	Onion bulb formation (HP:0003383)	1.61792557
79	Mask-like facies (HP:0000298)	1.61591522
80	Genu recurvatum (HP:0002816)	1.61126713
81	Abnormal ossification of hand bones (HP:0005921)	1.60800464
82	Premature skin wrinkling (HP:0100678)	1.60780084
83	Thoracic kyphosis (HP:0002942)	1.59830888
84	Dysmetric saccades (HP:0000641)	1.58587623
85	Supernumerary ribs (HP:0005815)	1.58582667
86	Dysostosis multiplex (HP:0000943)	1.58545142
87	Precocious puberty (HP:0000826)	1.58395926
88	Germ cell neoplasia (HP:0100728)	1.58162277
89	Hyperextensible skin (HP:0000974)	1.58103221
90	Vitreoretinal degeneration (HP:0000655)	1.57791448
91	Emphysema (HP:0002097)	1.56488283
92	Abnormality of polysaccharide metabolism (HP:0011012)	1.56385524
93	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.56385524
94	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.56385524
95	Abnormality of carpal bone ossification (HP:0006257)	1.55387447
96	Menorrhagia (HP:0000132)	1.55110612
97	Persistence of primary teeth (HP:0006335)	1.54567519
98	Hypertriglyceridemia (HP:0002155)	1.54521598
99	Abnormality of the acetabulum (HP:0003170)	1.52107083
100	Bowel diverticulosis (HP:0005222)	1.52090841

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIB3	4.24616976
2	CDK12	3.62853276
3	PRPF4B	3.08447782
4	FGFR4	3.06903815
5	ICK	2.98732973
6	SIK1	2.78792942
7	RIPK1	2.70593387
8	EEF2K	2.60213845
9	MAPK15	2.07456776
10	ERN1	1.97567860
11	MARK2	1.94836844
12	PDGFRA	1.79278277
13	SMG1	1.77635526
14	TTN	1.77502852
15	FGFR3	1.72152389
16	MAP3K7	1.68234600
17	SIK2	1.56322640
18	WNK1	1.55447677
19	DDR2	1.45393553
20	PKN2	1.42471453
21	TYRO3	1.42173679
22	MTOR	1.41509422
23	MAP3K13	1.37015329
24	CDC42BPA	1.34870360
25	MAP2K3	1.34598007
26	MAP3K6	1.28661108
27	CAMK1D	1.24844620
28	MAP3K10	1.24802998
29	RPS6KA2	1.17431177
30	BRD4	1.08188578
31	KSR2	1.08073518
32	MAP4K1	1.06848882
33	PRKD2	1.01189380
34	TNK2	0.98012518
35	RET	0.97168138
36	CAMK1G	0.94586998
37	PDPK1	0.94041561
38	HIPK2	0.92954025
39	PRKD3	0.92385431
40	RPS6KL1	0.91545591
41	RPS6KC1	0.91545591
42	ZAP70	0.90993495
43	PDGFRB	0.90603547
44	WNK4	0.89945993
45	NTRK3	0.89902087
46	CAMKK1	0.88707977
47	RIPK4	0.86515931
48	DYRK1B	0.85740200
49	BMX	0.84278077
50	MAPK11	0.84193035
51	NME1	0.83193095
52	PTK6	0.83092517
53	MST1R	0.82017727
54	MAPK12	0.81571676
55	ERBB2	0.77751501
56	EPHB1	0.77485514
57	MAP3K1	0.76728902
58	MAPK7	0.75070538
59	MAP2K6	0.73375966
60	RPS6KA6	0.72407504
61	SGK3	0.70049421
62	PRKAA2	0.69979327
63	PDK1	0.69789394
64	BLK	0.69785859
65	PRKCH	0.68584887
66	STK38	0.67118603
67	MAP3K14	0.60945720
68	MAP2K2	0.60786111
69	PRKAA1	0.60354187
70	JAK1	0.59232053
71	NTRK1	0.58498519
72	FGFR2	0.57304502
73	CAMK4	0.57118149
74	MAP3K2	0.54266142
75	TRPM7	0.54143961
76	ITK	0.51238360
77	SGK494	0.50422517
78	SGK223	0.50422517
79	FES	0.50225905
80	MAPK10	0.49425860
81	MAPK8	0.48871801
82	MAP3K3	0.47977757
83	TBK1	0.47776481
84	TYK2	0.47675512
85	PTK2	0.45565752
86	CDK4	0.45537840
87	TAOK2	0.45423259
88	TAOK1	0.44594524
89	CHUK	0.43951143
90	LATS2	0.43094716
91	MAP3K11	0.42216636
92	MAPK1	0.42078350
93	SGK2	0.41565461
94	JAK3	0.41147903
95	MAPK3	0.40907841
96	AKT3	0.40715195
97	HCK	0.40151112
98	SGK1	0.40095500
99	NTRK2	0.39604157
100	MET	0.38559477

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Other glycan degradation_Homo sapiens_hsa00511	2.57259808
2	Notch signaling pathway_Homo sapiens_hsa04330	2.10561901
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.88150451
4	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.81454709
5	Acute myeloid leukemia_Homo sapiens_hsa05221	1.72652014
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.67670297
7	VEGF signaling pathway_Homo sapiens_hsa04370	1.60479720
8	Non-small cell lung cancer_Homo sapiens_hsa05223	1.57063220
9	ECM-receptor interaction_Homo sapiens_hsa04512	1.56192253
10	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.50078434
11	mTOR signaling pathway_Homo sapiens_hsa04150	1.47993842
12	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.41777869
13	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.41757359
14	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.41267776
15	GnRH signaling pathway_Homo sapiens_hsa04912	1.37500110
16	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.36675287
17	Long-term potentiation_Homo sapiens_hsa04720	1.35326717
18	Focal adhesion_Homo sapiens_hsa04510	1.35112404
19	Choline metabolism in cancer_Homo sapiens_hsa05231	1.34984562
20	ErbB signaling pathway_Homo sapiens_hsa04012	1.34048322
21	Glioma_Homo sapiens_hsa05214	1.30494906
22	Lysine degradation_Homo sapiens_hsa00310	1.26143605
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.24735977
24	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.24016961
25	Insulin signaling pathway_Homo sapiens_hsa04910	1.19571058
26	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.17398182
27	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.16672408
28	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.15608612
29	ABC transporters_Homo sapiens_hsa02010	1.14490052
30	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.14261561
31	Pancreatic cancer_Homo sapiens_hsa05212	1.11256252
32	Estrogen signaling pathway_Homo sapiens_hsa04915	1.11127156
33	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.10316622
34	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.08391579
35	Endometrial cancer_Homo sapiens_hsa05213	1.07989208
36	Insulin resistance_Homo sapiens_hsa04931	1.07901500
37	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.07110069
38	Bladder cancer_Homo sapiens_hsa05219	1.05318479
39	Renal cell carcinoma_Homo sapiens_hsa05211	1.05241746
40	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.04364372
41	MicroRNAs in cancer_Homo sapiens_hsa05206	0.99941015
42	Prolactin signaling pathway_Homo sapiens_hsa04917	0.97589887
43	Complement and coagulation cascades_Homo sapiens_hsa04610	0.97588925
44	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.96876558
45	AMPK signaling pathway_Homo sapiens_hsa04152	0.93420602
46	Small cell lung cancer_Homo sapiens_hsa05222	0.91547028
47	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.91444492
48	Amoebiasis_Homo sapiens_hsa05146	0.91410128
49	Type II diabetes mellitus_Homo sapiens_hsa04930	0.91149366
50	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.91045362
51	Prion diseases_Homo sapiens_hsa05020	0.90711325
52	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.90366302
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.88968150
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.87326366
55	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.87231890
56	Proteoglycans in cancer_Homo sapiens_hsa05205	0.86843795
57	MAPK signaling pathway_Homo sapiens_hsa04010	0.86340126
58	Prostate cancer_Homo sapiens_hsa05215	0.85529072
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.84663947
60	Platelet activation_Homo sapiens_hsa04611	0.80454993
61	Osteoclast differentiation_Homo sapiens_hsa04380	0.77818840
62	TNF signaling pathway_Homo sapiens_hsa04668	0.76933605
63	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.74060378
64	Adherens junction_Homo sapiens_hsa04520	0.72906094
65	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.72344626
66	Glucagon signaling pathway_Homo sapiens_hsa04922	0.71280666
67	Toxoplasmosis_Homo sapiens_hsa05145	0.70671330
68	Gastric acid secretion_Homo sapiens_hsa04971	0.70174657
69	Melanogenesis_Homo sapiens_hsa04916	0.70091067
70	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69803564
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.69482717
72	FoxO signaling pathway_Homo sapiens_hsa04068	0.69006182
73	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.68037492
74	Hepatitis B_Homo sapiens_hsa05161	0.68008566
75	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.68007479
76	Rap1 signaling pathway_Homo sapiens_hsa04015	0.67696905
77	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.67361190
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.67229212
79	Protein digestion and absorption_Homo sapiens_hsa04974	0.67227410
80	Colorectal cancer_Homo sapiens_hsa05210	0.67133099
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.67092417
82	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.63252758
83	Cholinergic synapse_Homo sapiens_hsa04725	0.61992864
84	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.61251717
85	Bile secretion_Homo sapiens_hsa04976	0.61075941
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.60747485
87	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.58580616
88	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.57652507
89	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.57625235
90	Axon guidance_Homo sapiens_hsa04360	0.57362937
91	Endocytosis_Homo sapiens_hsa04144	0.57043850
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55083248
93	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.54949266
94	Thyroid cancer_Homo sapiens_hsa05216	0.53672087
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.53370651
96	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.52024358
97	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.51705183
98	Renin secretion_Homo sapiens_hsa04924	0.51701520
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.51619100
100	Hepatitis C_Homo sapiens_hsa05160	0.51592836

PKD1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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