PKDCC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.33803565
2Golgi transport vesicle coating (GO:0048200)5.33803565
3convergent extension (GO:0060026)4.17546670
4exocrine pancreas development (GO:0031017)4.13433841
5NADH metabolic process (GO:0006734)4.01848151
64-hydroxyproline metabolic process (GO:0019471)3.84916753
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.84912175
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83557733
9notochord development (GO:0030903)3.72338188
10positive regulation of nuclease activity (GO:0032075)3.68253206
11COPII vesicle coating (GO:0048208)3.68053827
12actin-mediated cell contraction (GO:0070252)3.47258871
13Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.47001200
14plasma membrane repair (GO:0001778)3.46995885
15positive regulation of glycogen biosynthetic process (GO:0045725)3.45592664
16type B pancreatic cell development (GO:0003323)3.44966402
17protein retention in ER lumen (GO:0006621)3.43991708
18positive regulation of hormone biosynthetic process (GO:0046886)3.43841168
19endocrine pancreas development (GO:0031018)3.36733281
20positive regulation of fatty acid beta-oxidation (GO:0032000)3.35322544
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.33558160
22L-phenylalanine metabolic process (GO:0006558)3.33558160
23regulation of nuclease activity (GO:0032069)3.33214709
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.32847567
25cardiac myofibril assembly (GO:0055003)3.29797047
26regulation of establishment of planar polarity (GO:0090175)3.29093420
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28412036
28L-phenylalanine catabolic process (GO:0006559)3.28412036
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.28092116
30non-canonical Wnt signaling pathway (GO:0035567)3.23802663
31glandular epithelial cell development (GO:0002068)3.23293252
32branching involved in salivary gland morphogenesis (GO:0060445)3.22999760
33metanephric mesenchyme development (GO:0072075)3.22392956
34endoplasmic reticulum unfolded protein response (GO:0030968)3.21113468
35lysine metabolic process (GO:0006553)3.19416458
36lysine catabolic process (GO:0006554)3.19416458
37regulation of cardioblast differentiation (GO:0051890)3.19062959
38gonadal mesoderm development (GO:0007506)3.16985357
39basement membrane organization (GO:0071711)3.14558511
40regulation of fatty acid beta-oxidation (GO:0031998)3.14478068
41sarcomere organization (GO:0045214)3.09823117
42establishment of apical/basal cell polarity (GO:0035089)3.06951713
43cellular response to unfolded protein (GO:0034620)3.06183254
44negative regulation of catenin import into nucleus (GO:0035414)3.05794263
45positive regulation of glycogen metabolic process (GO:0070875)3.05001847
46ER-nucleus signaling pathway (GO:0006984)3.01349748
47bundle of His cell to Purkinje myocyte communication (GO:0086069)2.97903604
48intestinal cholesterol absorption (GO:0030299)2.96701414
49establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.95751819
50tricarboxylic acid metabolic process (GO:0072350)2.94321107
51urea cycle (GO:0000050)2.93750107
52adherens junction assembly (GO:0034333)2.93710343
53maternal placenta development (GO:0001893)2.92997535
54kidney mesenchyme development (GO:0072074)2.91520594
55atrioventricular valve morphogenesis (GO:0003181)2.91000426
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90809269
57embryonic foregut morphogenesis (GO:0048617)2.90440450
58midgut development (GO:0007494)2.88789947
592-oxoglutarate metabolic process (GO:0006103)2.88116464
60insulin-like growth factor receptor signaling pathway (GO:0048009)2.88064769
61sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87149462
62myofibril assembly (GO:0030239)2.86835294
63positive regulation of fatty acid oxidation (GO:0046321)2.85752026
64glandular epithelial cell differentiation (GO:0002067)2.85509341
65carnitine shuttle (GO:0006853)2.84302169
66cellular response to topologically incorrect protein (GO:0035967)2.83810075
67regulation of cholesterol homeostasis (GO:2000188)2.83157001
68outer ear morphogenesis (GO:0042473)2.82855775
69muscle cell fate commitment (GO:0042693)2.82083572
70cGMP-mediated signaling (GO:0019934)2.81723514
71focal adhesion assembly (GO:0048041)2.81424663
72cell-substrate adherens junction assembly (GO:0007045)2.81424663
73creatine metabolic process (GO:0006600)2.79336270
74protein carboxylation (GO:0018214)2.78977280
75peptidyl-glutamic acid carboxylation (GO:0017187)2.78977280
76regulation of catenin import into nucleus (GO:0035412)2.77555342
77intestinal absorption (GO:0050892)2.77431139
78fatty acid transmembrane transport (GO:1902001)2.74260103
79actin filament-based movement (GO:0030048)2.74248393
80glyoxylate metabolic process (GO:0046487)2.73742930
81diacylglycerol metabolic process (GO:0046339)2.73606156
82retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72938225
83triglyceride catabolic process (GO:0019433)2.72227525
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72001908
85negative regulation of cell size (GO:0045792)2.71815487
86fatty acid homeostasis (GO:0055089)2.70894197
87organ induction (GO:0001759)2.69904826
88L-alpha-amino acid transmembrane transport (GO:1902475)2.69633195
89cardiac muscle contraction (GO:0060048)2.69616317
90alpha-linolenic acid metabolic process (GO:0036109)2.69510898
91regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.68337099
92sulfur amino acid catabolic process (GO:0000098)2.67857789
93negative regulation of potassium ion transmembrane transport (GO:1901380)2.66951159
94endothelial cell morphogenesis (GO:0001886)2.66722569
95lung vasculature development (GO:0060426)2.66328841
96negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.65152932
97neutral lipid catabolic process (GO:0046461)2.64602994
98acylglycerol catabolic process (GO:0046464)2.64602994
99regulation of fatty acid oxidation (GO:0046320)2.63585507
100urea metabolic process (GO:0019627)2.62502476
101regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.62457710
102triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.62191199
103heterochromatin organization (GO:0070828)2.62038369
104cochlea morphogenesis (GO:0090103)2.61942566
105homocysteine metabolic process (GO:0050667)2.61497992
106skeletal muscle contraction (GO:0003009)2.61181027
107polarized epithelial cell differentiation (GO:0030859)2.60215462
108epithelial cell-cell adhesion (GO:0090136)2.59711670
109muscle filament sliding (GO:0030049)2.58900686
110actin-myosin filament sliding (GO:0033275)2.58900686
111skeletal muscle fiber development (GO:0048741)2.58882886
112columnar/cuboidal epithelial cell development (GO:0002066)2.56335286
113complement activation, alternative pathway (GO:0006957)2.56103400
114striated muscle contraction (GO:0006941)2.55776031
115regulation of p38MAPK cascade (GO:1900744)2.55236134
116negative regulation of fibrinolysis (GO:0051918)2.53062925
117regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.52926222
118protein heterotrimerization (GO:0070208)2.52164653
119dorsal/ventral axis specification (GO:0009950)2.52008923
120cellular response to vitamin D (GO:0071305)2.51060774
121macroautophagy (GO:0016236)2.50746138
122cardiac muscle hypertrophy (GO:0003300)2.50457061
123vesicle coating (GO:0006901)2.50132870
124cell migration involved in sprouting angiogenesis (GO:0002042)2.49501891
125glycogen catabolic process (GO:0005980)2.49195521
126low-density lipoprotein particle clearance (GO:0034383)2.49110340
127gap junction assembly (GO:0016264)2.48815163
128lung-associated mesenchyme development (GO:0060484)2.48490454
129regulation of bile acid biosynthetic process (GO:0070857)2.48454766
130negative regulation of cell fate specification (GO:0009996)2.47942241
131paraxial mesoderm development (GO:0048339)2.47488773
132regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.46126565
133regulation of glycogen biosynthetic process (GO:0005979)2.45554192
134regulation of glucan biosynthetic process (GO:0010962)2.45554192
135glucan catabolic process (GO:0009251)2.45171169
136positive regulation of glycolytic process (GO:0045821)2.45149709
137cardiac muscle hypertrophy in response to stress (GO:0014898)2.44475693
138muscle hypertrophy in response to stress (GO:0003299)2.44475693
139cardiac muscle adaptation (GO:0014887)2.44475693
140response to unfolded protein (GO:0006986)2.42785730
141establishment of monopolar cell polarity (GO:0061162)2.42423150
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.42423150
143respiratory system process (GO:0003016)2.42223790
144positive regulation of p38MAPK cascade (GO:1900745)2.42021413
145positive regulation of hormone metabolic process (GO:0032352)2.41999022
146regulation of cell fate specification (GO:0042659)2.41740993
147regulation of skeletal muscle contraction (GO:0014819)2.41045429
148positive regulation of catenin import into nucleus (GO:0035413)2.40466656
149negative regulation of chondrocyte differentiation (GO:0032331)2.40133906
150triglyceride homeostasis (GO:0070328)2.39919158
151acylglycerol homeostasis (GO:0055090)2.39919158
152mesenchyme development (GO:0060485)2.39791114
153response to endoplasmic reticulum stress (GO:0034976)2.39180834
154growth hormone secretion (GO:0030252)2.39158961
155actomyosin structure organization (GO:0031032)2.38944338
156nitrogen cycle metabolic process (GO:0071941)2.38883691
157myoblast migration (GO:0051451)2.37867605
158positive regulation of histone deacetylation (GO:0031065)2.37735952
159striated muscle hypertrophy (GO:0014897)2.37422735
160epithelial cell fate commitment (GO:0072148)2.37135504
161coronary vasculature morphogenesis (GO:0060977)2.36677525
162aspartate family amino acid catabolic process (GO:0009068)2.36562689
163regulation of actin filament-based movement (GO:1903115)2.36470342
164embryonic skeletal joint morphogenesis (GO:0060272)2.35838489
165vascular endothelial growth factor signaling pathway (GO:0038084)2.35420442
166aromatic amino acid family catabolic process (GO:0009074)2.34669331
167peptide hormone processing (GO:0016486)2.33968309
168regulation of posttranscriptional gene silencing (GO:0060147)2.33695331
169regulation of gene silencing by miRNA (GO:0060964)2.33695331
170regulation of gene silencing by RNA (GO:0060966)2.33695331
171response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.33577729
172cardiac muscle cell development (GO:0055013)2.33526912
173embryonic retina morphogenesis in camera-type eye (GO:0060059)2.33226493
174membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32744273
175apoptotic cell clearance (GO:0043277)2.31927403
176bone trabecula formation (GO:0060346)2.31442785
177hippo signaling (GO:0035329)2.31120718
178neuron projection extension involved in neuron projection guidance (GO:1902284)2.28076158
179axon extension involved in axon guidance (GO:0048846)2.28076158
180establishment or maintenance of apical/basal cell polarity (GO:0035088)2.27277079
181establishment or maintenance of bipolar cell polarity (GO:0061245)2.27277079
182cardiac muscle tissue morphogenesis (GO:0055008)2.27249868
183bone morphogenesis (GO:0060349)2.26219641
184regulation of glucose import in response to insulin stimulus (GO:2001273)2.25605208
185generation of neurons (GO:0048699)2.25449037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.79848428
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.23113198
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15179178
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92930258
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.61581842
6CLOCK_20551151_ChIP-Seq_293T_Human3.36308676
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07146225
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.88340449
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.69262008
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.68705017
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54285805
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48378626
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.38439664
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19291236
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18805465
16ZNF263_19887448_ChIP-Seq_K562_Human2.02795461
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.99510609
18* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98083103
19LXR_22292898_ChIP-Seq_THP-1_Human1.96979791
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92259612
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.89363549
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.89363549
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86977251
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86841620
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80812778
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80812778
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.80219888
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.74118474
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73422192
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72801003
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72451481
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72451481
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72451481
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68248627
35NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66713056
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66641748
37RACK7_27058665_Chip-Seq_MCF-7_Human1.66439195
38GATA1_22025678_ChIP-Seq_K562_Human1.65698443
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65104035
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62621077
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60555804
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.60011360
43DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.59968655
44CREB1_26743006_Chip-Seq_LNCaP_Human1.58392878
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.58039366
46CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56300190
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52794418
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49340619
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48781230
50* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.48780815
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48657706
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.47387738
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45705278
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.43527832
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.42506370
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42014692
57ATF3_27146783_Chip-Seq_COLON_Human1.41984737
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.41866215
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.40224603
60* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40049631
61STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.39231346
62KDM2B_26808549_Chip-Seq_DND41_Human1.36971530
63FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35985079
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35720134
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33813543
66* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33552246
67* KDM2B_26808549_Chip-Seq_K562_Human1.32796304
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31944310
69* ISL1_27105846_Chip-Seq_CPCs_Mouse1.29889234
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28728145
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26656272
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26620682
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.26593875
74SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25768198
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25629426
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.24972310
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24943071
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.24664191
79* TET1_21451524_ChIP-Seq_MESCs_Mouse1.23846994
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23550612
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.23500555
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22463640
83* GATA6_25053715_ChIP-Seq_YYC3_Human1.22202439
84UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21573794
85TCF7_22412390_ChIP-Seq_EML_Mouse1.21548871
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21018925
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20199962
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19786224
89SMC4_20622854_ChIP-Seq_HELA_Human1.16908224
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.16358228
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16149478
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15440626
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14976143
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.14595067
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14378346
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14357092
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13596539
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13347471
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12284823
100* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12113583
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.12082366
102RING1B_27294783_Chip-Seq_ESCs_Mouse1.10415938
103OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10406600
104* RNF2_27304074_Chip-Seq_ESCs_Mouse1.10276326
105SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09729139
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09329130
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.09157585
108* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08916998
109MYC_22102868_ChIP-Seq_BL_Human1.08667066
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08316040
111CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08194642
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07421796
113P68_20966046_ChIP-Seq_HELA_Human1.07068839
114NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06694664
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05828669
116* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05819859
117FOXO3_23340844_ChIP-Seq_DLD1_Human1.04751715
118* MYC_27129775_Chip-Seq_CORNEA_Mouse1.04147671
119SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04072556
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03702894
121TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03644551
122CHD1_26751641_Chip-Seq_LNCaP_Human1.02572328
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01799796
124GATA1_19941826_ChIP-Seq_K562_Human0.99760701
125CTCF_27219007_Chip-Seq_Bcells_Human0.99608105
126HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98572567
127GATA4_25053715_ChIP-Seq_YYC3_Human0.98487374
128OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97715668
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97227045
130* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96152397
131NCOR1_26117541_ChIP-Seq_K562_Human0.95997886
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95686096
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95264680
134EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94668320
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.93671572
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.91729900
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.90731998
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.89770106
139SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89585876
140FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88933269
141HNF4A_19822575_ChIP-Seq_HepG2_Human0.86557842
142SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86466439
143TP63_22573176_ChIP-Seq_HFKS_Human0.86296074
144UBF1/2_26484160_Chip-Seq_HMECs_Human0.85760249
145NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85373483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.30979895
2MP0003705_abnormal_hypodermis_morpholog3.12491365
3MP0002837_dystrophic_cardiac_calcinosis3.07039932
4MP0002139_abnormal_hepatobiliary_system2.94816277
5MP0000566_synostosis2.44008329
6MP0005365_abnormal_bile_salt2.34946528
7MP0005085_abnormal_gallbladder_physiolo2.30297972
8MP0003195_calcinosis2.29783988
9MP0004858_abnormal_nervous_system2.27738431
10MP0003252_abnormal_bile_duct2.27399808
11MP0005360_urolithiasis2.27236359
12MP0004272_abnormal_basement_membrane2.14841633
13MP0004084_abnormal_cardiac_muscle2.12955610
14MP0002254_reproductive_system_inflammat2.08067932
15MP0008438_abnormal_cutaneous_collagen2.07791891
16MP0000751_myopathy1.98141482
17MP0003122_maternal_imprinting1.97463911
18MP0002877_abnormal_melanocyte_morpholog1.89690864
19MP0003123_paternal_imprinting1.86610833
20MP0004036_abnormal_muscle_relaxation1.84920536
21MP0006054_spinal_hemorrhage1.82304240
22MP0004145_abnormal_muscle_electrophysio1.80882546
23MP0000013_abnormal_adipose_tissue1.79421684
24MP0002909_abnormal_adrenal_gland1.79317317
25MP0001346_abnormal_lacrimal_gland1.77688898
26MP0002249_abnormal_larynx_morphology1.76928157
27MP0010368_abnormal_lymphatic_system1.74190734
28MP0001299_abnormal_eye_distance/1.73940597
29MP0000678_abnormal_parathyroid_gland1.71740828
30MP0001944_abnormal_pancreas_morphology1.65472579
31MP0010030_abnormal_orbit_morphology1.60064018
32MP0009780_abnormal_chondrocyte_physiolo1.57115994
33MP0000537_abnormal_urethra_morphology1.55159708
34MP0002234_abnormal_pharynx_morphology1.53834911
35MP0002697_abnormal_eye_size1.51681310
36MP0003941_abnormal_skin_development1.50750751
37MP0005409_darkened_coat_color1.50675323
38MP0005083_abnormal_biliary_tract1.50341235
39MP0000003_abnormal_adipose_tissue1.50270448
40MP0002693_abnormal_pancreas_physiology1.48426066
41MP0004185_abnormal_adipocyte_glucose1.47499949
42MP0005220_abnormal_exocrine_pancreas1.46000250
43MP0000749_muscle_degeneration1.45676248
44MP0004087_abnormal_muscle_fiber1.45526294
45* MP0002896_abnormal_bone_mineralization1.40428056
46MP0005503_abnormal_tendon_morphology1.38848661
47MP0001661_extended_life_span1.38711582
48MP0002269_muscular_atrophy1.38580946
49MP0003119_abnormal_digestive_system1.38280977
50MP0001666_abnormal_nutrient_absorption1.36858908
51MP0005670_abnormal_white_adipose1.36635378
52MP0002089_abnormal_postnatal_growth/wei1.33073144
53MP0004130_abnormal_muscle_cell1.32235805
54MP0002971_abnormal_brown_adipose1.32158044
55MP0000049_abnormal_middle_ear1.32125642
56MP0000462_abnormal_digestive_system1.31660197
57MP0005375_adipose_tissue_phenotype1.29570562
58MP0010329_abnormal_lipoprotein_level1.28765286
59MP0005666_abnormal_adipose_tissue1.28265264
60MP0005187_abnormal_penis_morphology1.27793044
61MP0009053_abnormal_anal_canal1.26345001
62MP0009840_abnormal_foam_cell1.25904142
63MP0009379_abnormal_foot_pigmentation1.24659934
64MP0000747_muscle_weakness1.22800971
65MP0005076_abnormal_cell_differentiation1.22493783
66MP0003385_abnormal_body_wall1.21680443
67MP0005275_abnormal_skin_tensile1.21546576
68MP0003942_abnormal_urinary_system1.21184940
69MP0010630_abnormal_cardiac_muscle1.20088798
70MP0005330_cardiomyopathy1.18841336
71MP0002078_abnormal_glucose_homeostasis1.16989702
72MP0000750_abnormal_muscle_regeneration1.16790004
73MP0005451_abnormal_body_composition1.16385034
74MP0004233_abnormal_muscle_weight1.15387652
75MP0002932_abnormal_joint_morphology1.14420263
76MP0006138_congestive_heart_failure1.11320694
77MP0004264_abnormal_extraembryonic_tissu1.10310719
78MP0005623_abnormal_meninges_morphology1.09160366
79MP0005508_abnormal_skeleton_morphology1.09096141
80MP0003300_gastrointestinal_ulcer1.06983378
81MP0005620_abnormal_muscle_contractility1.06816228
82MP0000762_abnormal_tongue_morphology1.06621447
83MP0009384_cardiac_valve_regurgitation1.06522450
84MP0005257_abnormal_intraocular_pressure1.06047674
85MP0002138_abnormal_hepatobiliary_system1.05102501
86MP0002106_abnormal_muscle_physiology1.04975905
87MP0003937_abnormal_limbs/digits/tail_de1.03833913
88MP0000759_abnormal_skeletal_muscle1.03537011
89MP0000516_abnormal_urinary_system1.03022290
90MP0005367_renal/urinary_system_phenotyp1.03022290
91MP0009250_abnormal_appendicular_skeleto1.02417059
92MP0000534_abnormal_ureter_morphology1.01971284
93MP0008961_abnormal_basal_metabolism1.00997954
94MP0010234_abnormal_vibrissa_follicle1.00807203
95MP0003806_abnormal_nucleotide_metabolis1.00784640
96* MP0002233_abnormal_nose_morphology1.00050340
97MP0000733_abnormal_muscle_development0.99164405
98MP0008875_abnormal_xenobiotic_pharmacok0.98800760
99MP0004043_abnormal_pH_regulation0.98343020
100MP0003868_abnormal_feces_composition0.97035871
101MP0002108_abnormal_muscle_morphology0.96383060
102MP0005369_muscle_phenotype0.96096797
103MP0009643_abnormal_urine_homeostasis0.95726298
104MP0002972_abnormal_cardiac_muscle0.95503444
105MP0003566_abnormal_cell_adhesion0.94517483
106MP0004215_abnormal_myocardial_fiber0.94466697
107MP0001958_emphysema0.94235670
108MP0003938_abnormal_ear_development0.92925341
109MP0001348_abnormal_lacrimal_gland0.92713274
110MP0001544_abnormal_cardiovascular_syste0.92633608
111MP0005385_cardiovascular_system_phenoty0.92633608
112* MP0009672_abnormal_birth_weight0.92332613
113* MP0002111_abnormal_tail_morphology0.92269427
114* MP0002114_abnormal_axial_skeleton0.91999809
115MP0001270_distended_abdomen0.91048555
116MP0000609_abnormal_liver_physiology0.90155891
117MP0001879_abnormal_lymphatic_vessel0.89810953
118MP0001849_ear_inflammation0.88779225
119MP0002127_abnormal_cardiovascular_syste0.87863307
120MP0003137_abnormal_impulse_conducting0.87560775
121* MP0000428_abnormal_craniofacial_morphol0.87172206
122MP0003646_muscle_fatigue0.86515140
123MP0005332_abnormal_amino_acid0.86493925
124* MP0003115_abnormal_respiratory_system0.85430167
125* MP0002116_abnormal_craniofacial_bone0.84244342
126MP0003567_abnormal_fetal_cardiomyocyte0.83584528
127MP0000432_abnormal_head_morphology0.83167678
128MP0002118_abnormal_lipid_homeostasis0.83075415
129MP0008775_abnormal_heart_ventricle0.82464651
130MP0003279_aneurysm0.81563927
131MP0002092_abnormal_eye_morphology0.80607946
132MP0001286_abnormal_eye_development0.80346664
133MP0002085_abnormal_embryonic_tissue0.77727377
134MP0003984_embryonic_growth_retardation0.77217667
135MP0000266_abnormal_heart_morphology0.75810448
136MP0003878_abnormal_ear_physiology0.74826136
137MP0005377_hearing/vestibular/ear_phenot0.74826136
138* MP0003755_abnormal_palate_morphology0.74755872
139MP0002088_abnormal_embryonic_growth/wei0.73832140
140MP0001293_anophthalmia0.73195154

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.69760011
2Hypoglycemic coma (HP:0001325)4.56292878
3Calcaneovalgus deformity (HP:0001848)4.23969377
4Ketoacidosis (HP:0001993)3.92590355
5Hyperglycemia (HP:0003074)3.83763079
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.75131300
7Hypoglycemic seizures (HP:0002173)3.73553126
8Deformed tarsal bones (HP:0008119)3.71213633
9Nemaline bodies (HP:0003798)3.67623973
10Pancreatic islet-cell hyperplasia (HP:0004510)3.60494295
11Abnormality of endocrine pancreas physiology (HP:0012093)3.55270115
12Abnormality of the pancreatic islet cells (HP:0006476)3.55270115
13Late onset (HP:0003584)3.44975320
14Abnormality of the calcaneus (HP:0008364)3.39783401
15Myopathic facies (HP:0002058)3.36420276
16Myoglobinuria (HP:0002913)3.27246069
17Type 1 muscle fiber predominance (HP:0003803)3.12415508
18Ketosis (HP:0001946)3.09200489
19Deep venous thrombosis (HP:0002625)3.07164054
20Protrusio acetabuli (HP:0003179)3.04099007
21Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.00937770
22Right ventricular cardiomyopathy (HP:0011663)2.92943894
23Exercise-induced muscle cramps (HP:0003710)2.88267151
24Intrahepatic cholestasis (HP:0001406)2.85884262
25Distal arthrogryposis (HP:0005684)2.84489331
26Insulin-resistant diabetes mellitus (HP:0000831)2.80048872
27Exercise-induced myalgia (HP:0003738)2.79819791
28Centrally nucleated skeletal muscle fibers (HP:0003687)2.78806505
29Sudden death (HP:0001699)2.75227191
30Symptomatic seizures (HP:0011145)2.75122376
31Thin ribs (HP:0000883)2.73387974
32Lymphangioma (HP:0100764)2.68789750
33Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64617763
34Increased connective tissue (HP:0009025)2.62069112
35Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61921578
36Large for gestational age (HP:0001520)2.59695316
37Ventricular tachycardia (HP:0004756)2.57566746
38Asymmetric septal hypertrophy (HP:0001670)2.51507960
39Hyporeflexia of lower limbs (HP:0002600)2.51466609
40Cerebral aneurysm (HP:0004944)2.49978905
41Renal duplication (HP:0000075)2.48400280
42Mildly elevated creatine phosphokinase (HP:0008180)2.46998705
43Xanthomatosis (HP:0000991)2.45399497
44Coronal craniosynostosis (HP:0004440)2.43068363
45Insulin resistance (HP:0000855)2.40349181
46Ulnar deviation of the wrist (HP:0003049)2.39531479
47Skin nodule (HP:0200036)2.36184498
48Subaortic stenosis (HP:0001682)2.33991567
49Abnormality of the left ventricular outflow tract (HP:0011103)2.33991567
50Broad metatarsal (HP:0001783)2.33910941
51Calf muscle hypertrophy (HP:0008981)2.30593497
52Choanal stenosis (HP:0000452)2.29511471
53Partial duplication of thumb phalanx (HP:0009944)2.27118497
54Shallow orbits (HP:0000586)2.26587872
55Abnormality of the intrinsic pathway (HP:0010989)2.24705998
56Aneurysm (HP:0002617)2.21957187
57Premature rupture of membranes (HP:0001788)2.21326355
58Increased variability in muscle fiber diameter (HP:0003557)2.21252279
59Back pain (HP:0003418)2.20453594
60Rectal prolapse (HP:0002035)2.19258766
61Muscle hypertrophy of the lower extremities (HP:0008968)2.18964354
62Abnormal pancreas size (HP:0012094)2.18872662
63Hypoplastic ischia (HP:0003175)2.17905235
64Abnormality of the common coagulation pathway (HP:0010990)2.15761263
65Muscle fiber splitting (HP:0003555)2.15041030
66Hepatoblastoma (HP:0002884)2.14770554
67Unilateral renal agenesis (HP:0000122)2.13871851
68Bladder diverticulum (HP:0000015)2.13148674
69Ulnar bowing (HP:0003031)2.12556194
70Partial duplication of the phalanx of hand (HP:0009999)2.08750854
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.08488973
72Distal lower limb amyotrophy (HP:0008944)2.08446219
73Long toe (HP:0010511)2.06843395
74Hypoalphalipoproteinemia (HP:0003233)2.05380466
75Difficulty climbing stairs (HP:0003551)2.02750425
76Turricephaly (HP:0000262)2.02380170
77Ankle contracture (HP:0006466)2.02334836
78Palpitations (HP:0001962)2.00919965
79Abnormality of the ischium (HP:0003174)2.00389570
80Neonatal short-limb short stature (HP:0008921)1.99663748
81Pterygium (HP:0001059)1.99647900
82Fragile skin (HP:0001030)1.95161055
83Vertebral compression fractures (HP:0002953)1.92827717
84Distal lower limb muscle weakness (HP:0009053)1.92812492
85Cervical subluxation (HP:0003308)1.92493502
86Mitral valve prolapse (HP:0001634)1.92410061
87Abnormality of skeletal muscle fiber size (HP:0012084)1.91806122
88Enlarged penis (HP:0000040)1.91765857
89Aortic dissection (HP:0002647)1.91393652
90Hypercortisolism (HP:0001578)1.90196670
91Abnormality of the calf musculature (HP:0001430)1.90049678
92Complement deficiency (HP:0004431)1.89852806
93Bundle branch block (HP:0011710)1.89821263
94Rimmed vacuoles (HP:0003805)1.89557061
95Hip contracture (HP:0003273)1.88473377
96Renovascular hypertension (HP:0100817)1.87578114
97Myotonia (HP:0002486)1.86699057
98Biconcave vertebral bodies (HP:0004586)1.86615750
99Neck muscle weakness (HP:0000467)1.86407796
100Rhabdomyolysis (HP:0003201)1.84592717
101Hypolipoproteinemia (HP:0010981)1.83861821
102Thin bony cortex (HP:0002753)1.83859115
103Difficulty running (HP:0009046)1.81973333
104Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80415170
105Spinal rigidity (HP:0003306)1.80131611
106Hyperacusis (HP:0010780)1.80026831
107Atrioventricular block (HP:0001678)1.79363237
108Limited hip movement (HP:0008800)1.79238007
109Hypobetalipoproteinemia (HP:0003563)1.78359219
110Dilated cardiomyopathy (HP:0001644)1.77413884
111Bulbar palsy (HP:0001283)1.75724657
112Hyperammonemia (HP:0001987)1.75259367
113Hemorrhage of the eye (HP:0011885)1.72483597
114Asymmetry of the thorax (HP:0001555)1.71986458
115Aortic aneurysm (HP:0004942)1.71817230
116EMG: myopathic abnormalities (HP:0003458)1.71728959
117Abnormality of the middle phalanges of the toes (HP:0010183)1.71339492
118Broad palm (HP:0001169)1.71245782
119Limb-girdle muscle atrophy (HP:0003797)1.70999013
120Abnormal gallbladder morphology (HP:0012437)1.70800618
121Exostoses (HP:0100777)1.70461633
122Muscle stiffness (HP:0003552)1.70439794
123Lipoatrophy (HP:0100578)1.70168148
124Abdominal distention (HP:0003270)1.69895102
125Epidermoid cyst (HP:0200040)1.69701053
126Vertebral clefting (HP:0008428)1.69688699
127Metaphyseal cupping (HP:0003021)1.69554533
128Abnormal cartilage morphology (HP:0002763)1.68973886
129Abnormality of the 4th metacarpal (HP:0010012)1.68525586
130Infantile muscular hypotonia (HP:0008947)1.68158099
131Flat acetabular roof (HP:0003180)1.67666116
132Blue sclerae (HP:0000592)1.66986755
133Arnold-Chiari malformation (HP:0002308)1.66618528
134Malignant hyperthermia (HP:0002047)1.66471113
135Bell-shaped thorax (HP:0001591)1.66170710
136Ectopia lentis (HP:0001083)1.65819754
137Hypokalemia (HP:0002900)1.64375105
138Cholelithiasis (HP:0001081)1.64238717
139Elfin facies (HP:0004428)1.63974421
140Lower limb amyotrophy (HP:0007210)1.63614015
141Breech presentation (HP:0001623)1.63496182
142Disproportionate tall stature (HP:0001519)1.63274876
143Vitreoretinal degeneration (HP:0000655)1.63007698
144Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62866202
145Short 4th metacarpal (HP:0010044)1.62866202
146Muscle fiber inclusion bodies (HP:0100299)1.62802937
147Gout (HP:0001997)1.62209937
148Progressive muscle weakness (HP:0003323)1.61949810
149Absent phalangeal crease (HP:0006109)1.61044105
150Adducted thumb (HP:0001181)1.60907531
151Preaxial foot polydactyly (HP:0001841)1.60756373
152Soft skin (HP:0000977)1.60295777
153Preauricular pit (HP:0004467)1.59956896
154Bronchomalacia (HP:0002780)1.59606819
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59449089
156Round ear (HP:0100830)1.59213654
157Protuberant abdomen (HP:0001538)1.58080159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.88751195
2PKN23.63815380
3MAP3K103.35843523
4TTN3.25164799
5INSRR3.16142965
6PTK62.72669264
7ERN12.68803721
8PDGFRA2.68308705
9LATS12.61856447
10PDK22.45499808
11PASK2.44019246
12RIPK12.11195961
13BCKDK2.02006933
14TYRO31.98988186
15SIK11.93031146
16EPHB21.87583329
17PRKD31.80883284
18SMG11.78266741
19FLT31.65868364
20TAOK31.65170931
21FGFR41.54322292
22PTK21.44167086
23MET1.36032138
24EPHA31.35955967
25TIE11.32810427
26OBSCN1.31943613
27LMTK21.31865863
28WNK41.29172415
29DDR21.26594924
30PHKG11.23392934
31PHKG21.23392934
32SCYL21.23279608
33ICK1.15734131
34MAPK151.14794468
35FRK1.14663304
36MTOR1.14437000
37MAP2K31.12689103
38EPHA41.09355739
39PRPF4B1.07339369
40PAK41.05124773
41MAP2K21.04868363
42LATS21.04863048
43MOS1.03483549
44HIPK21.02960148
45MAPK121.02830386
46MAP3K11.02508880
47CDC42BPA1.00000342
48PIK3CG0.99607701
49DMPK0.99122392
50FER0.98696510
51DYRK1B0.96347804
52MAP3K20.94889814
53NEK90.94389907
54MAP3K30.92255891
55MST1R0.85555494
56MYLK0.84545020
57ILK0.83307592
58RET0.81899378
59PAK20.80087358
60TGFBR10.80052250
61NEK10.79177274
62MAP3K70.79092798
63EEF2K0.77932424
64MKNK10.77630514
65PAK30.76041926
66PDGFRB0.75464414
67MUSK0.75050008
68LRRK20.75005978
69STK38L0.74955261
70AKT20.72796150
71PRKD10.70996818
72EPHB10.70862387
73MAPK70.69928847
74PRKG20.69604000
75ERBB20.68770536
76MARK20.65978459
77KDR0.65960754
78FGFR10.65946843
79CAMK10.65356545
80PRKAA10.62599897
81TGFBR20.58982454
82PRKCH0.57362894
83PDK30.56580882
84PDK40.56580882
85RPS6KL10.55823883
86RPS6KC10.55823883
87CDK190.55771256
88CDC70.55323534
89GSK3A0.53899854
90MAP3K60.52907431
91JAK20.52880198
92BMX0.52830735
93TTK0.52612338
94CDK60.52273274
95PDPK10.51858987
96PRKAA20.51683946
97MAP2K40.49645366
98UHMK10.48823446
99ROCK10.48361428
100STK30.47358183
101CAMK40.46534420
102NME10.46283192
103MKNK20.46267548
104RPS6KB20.45885581
105FGFR30.45507761
106KSR20.44816603
107MAP2K10.44518109
108STK110.43463561
109MAP3K80.43299276
110CAMK1D0.43102891
111ALK0.42736675
112FGFR20.41897575
113PIK3CA0.41861307
114STK240.41468539
115CAMK1G0.41222238
116WNK10.40820498
117EPHA20.40655712
118MAPK110.40345646
119NEK20.39675216
120CDK11A0.39551217
121WNK30.38488198
122ERBB40.38230858
123TLK10.38185241
124TESK10.36473538
125NTRK10.35979817
126CDK150.35496648
127CDK120.35470765
128CDK40.35441971
129RPS6KA60.34582513
130MAPK100.34085342
131BRD40.33753780
132CDK70.33717287
133MAPK40.31958368
134RPS6KA20.31167157
135PRKACG0.30973933
136GSK3B0.30813365
137PRKD20.30520976
138DAPK30.29943122
139RPS6KA10.29704967
140TRPM70.29473863

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.15420729
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14319466
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49991338
4Fatty acid degradation_Homo sapiens_hsa000712.41306823
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.37794568
6Tryptophan metabolism_Homo sapiens_hsa003802.25417805
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24438707
8Nitrogen metabolism_Homo sapiens_hsa009102.23055750
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20329458
10Arginine biosynthesis_Homo sapiens_hsa002202.17344544
11Selenocompound metabolism_Homo sapiens_hsa004502.08099624
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.04722980
13Sulfur metabolism_Homo sapiens_hsa009201.97069640
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91656581
15Fat digestion and absorption_Homo sapiens_hsa049751.85552608
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73822885
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68404010
18Propanoate metabolism_Homo sapiens_hsa006401.67486313
19Lysine degradation_Homo sapiens_hsa003101.57672857
20Butanoate metabolism_Homo sapiens_hsa006501.57624164
21Starch and sucrose metabolism_Homo sapiens_hsa005001.51945762
22Fatty acid metabolism_Homo sapiens_hsa012121.51369525
23Insulin resistance_Homo sapiens_hsa049311.49282319
24PPAR signaling pathway_Homo sapiens_hsa033201.41110057
25Renin-angiotensin system_Homo sapiens_hsa046141.39987694
26Fructose and mannose metabolism_Homo sapiens_hsa000511.39215394
27Type II diabetes mellitus_Homo sapiens_hsa049301.37944644
28Protein digestion and absorption_Homo sapiens_hsa049741.36594318
29Complement and coagulation cascades_Homo sapiens_hsa046101.35968364
30Vitamin digestion and absorption_Homo sapiens_hsa049771.35881139
31Carbon metabolism_Homo sapiens_hsa012001.28664294
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.25303921
33Phenylalanine metabolism_Homo sapiens_hsa003601.24428156
34Glucagon signaling pathway_Homo sapiens_hsa049221.20989542
35Pyruvate metabolism_Homo sapiens_hsa006201.18870749
36Dilated cardiomyopathy_Homo sapiens_hsa054141.16922756
37Bile secretion_Homo sapiens_hsa049761.15425051
38Pentose phosphate pathway_Homo sapiens_hsa000301.13406733
39Wnt signaling pathway_Homo sapiens_hsa043101.13180427
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12300481
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11462054
42Insulin secretion_Homo sapiens_hsa049111.08163011
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07281844
44Histidine metabolism_Homo sapiens_hsa003401.06473041
45Basal cell carcinoma_Homo sapiens_hsa052171.02080545
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01717077
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01532097
48Cardiac muscle contraction_Homo sapiens_hsa042600.99623032
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98518656
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98492609
51ECM-receptor interaction_Homo sapiens_hsa045120.96264241
52Biosynthesis of amino acids_Homo sapiens_hsa012300.96187087
53Fatty acid biosynthesis_Homo sapiens_hsa000610.93421709
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92891923
55Hedgehog signaling pathway_Homo sapiens_hsa043400.90830513
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89850963
57beta-Alanine metabolism_Homo sapiens_hsa004100.88762266
58Focal adhesion_Homo sapiens_hsa045100.88396490
59TGF-beta signaling pathway_Homo sapiens_hsa043500.86683714
60Bladder cancer_Homo sapiens_hsa052190.85423716
61ABC transporters_Homo sapiens_hsa020100.85363875
62Protein export_Homo sapiens_hsa030600.84229708
63Insulin signaling pathway_Homo sapiens_hsa049100.84164239
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81867437
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80262887
66Arginine and proline metabolism_Homo sapiens_hsa003300.79564301
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.79156788
68AMPK signaling pathway_Homo sapiens_hsa041520.78030367
69Tyrosine metabolism_Homo sapiens_hsa003500.77289800
70Adherens junction_Homo sapiens_hsa045200.76681928
71Axon guidance_Homo sapiens_hsa043600.75496473
72Peroxisome_Homo sapiens_hsa041460.74311204
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.71142180
74Other glycan degradation_Homo sapiens_hsa005110.70920651
75Renin secretion_Homo sapiens_hsa049240.69689856
76Vitamin B6 metabolism_Homo sapiens_hsa007500.69069170
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.68726471
78MicroRNAs in cancer_Homo sapiens_hsa052060.67791364
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.67128881
80Galactose metabolism_Homo sapiens_hsa000520.67057166
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66591833
82Proteoglycans in cancer_Homo sapiens_hsa052050.65942457
83Pancreatic secretion_Homo sapiens_hsa049720.65751577
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65305981
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.65287672
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.63469360
87Folate biosynthesis_Homo sapiens_hsa007900.60462997
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.59618975
89Sulfur relay system_Homo sapiens_hsa041220.59338174
90Amoebiasis_Homo sapiens_hsa051460.58649960
91Chemical carcinogenesis_Homo sapiens_hsa052040.58425779
92Tight junction_Homo sapiens_hsa045300.58324041
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57698223
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57076654
95Prion diseases_Homo sapiens_hsa050200.56836021
96Hippo signaling pathway_Homo sapiens_hsa043900.55601280
97Endometrial cancer_Homo sapiens_hsa052130.55090301
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53965143
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53897244
100Pathways in cancer_Homo sapiens_hsa052000.52604418
101mTOR signaling pathway_Homo sapiens_hsa041500.50647174
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48883807
103Retinol metabolism_Homo sapiens_hsa008300.48785802
104Caffeine metabolism_Homo sapiens_hsa002320.47629427
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47447776
106Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45188542
107Thyroid cancer_Homo sapiens_hsa052160.44436883
108GnRH signaling pathway_Homo sapiens_hsa049120.44167765
109Gap junction_Homo sapiens_hsa045400.44084544
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41607891
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41270769
112Mineral absorption_Homo sapiens_hsa049780.40623612
113One carbon pool by folate_Homo sapiens_hsa006700.39749125
114Thyroid hormone synthesis_Homo sapiens_hsa049180.38821597
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38610107
116Glioma_Homo sapiens_hsa052140.37519655
117Estrogen signaling pathway_Homo sapiens_hsa049150.37515773
118Chronic myeloid leukemia_Homo sapiens_hsa052200.37124890
119Glycerolipid metabolism_Homo sapiens_hsa005610.36843979
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36424395
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36383098
122Notch signaling pathway_Homo sapiens_hsa043300.36365706
123Small cell lung cancer_Homo sapiens_hsa052220.36260211
124Ovarian steroidogenesis_Homo sapiens_hsa049130.35921434
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34704031
126N-Glycan biosynthesis_Homo sapiens_hsa005100.33951527
127Melanogenesis_Homo sapiens_hsa049160.33910203
128Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33656287
129Circadian rhythm_Homo sapiens_hsa047100.33407525
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.31420049

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