PKHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)7.32125902
2drug transmembrane transport (GO:0006855)7.12561310
3lysine metabolic process (GO:0006553)6.65312069
4lysine catabolic process (GO:0006554)6.65312069
5regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.60852295
6cysteine metabolic process (GO:0006534)6.43842999
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.06648008
8L-phenylalanine catabolic process (GO:0006559)6.06648008
9homocysteine metabolic process (GO:0050667)5.97556929
10L-phenylalanine metabolic process (GO:0006558)5.86373035
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.86373035
12nephron tubule formation (GO:0072079)5.83206878
13drug transport (GO:0015893)5.82267514
14glyoxylate metabolic process (GO:0046487)5.71964525
15aromatic amino acid family catabolic process (GO:0009074)5.52742830
16negative regulation of metanephros development (GO:0072217)5.28844516
17organic cation transport (GO:0015695)5.21824276
18drug catabolic process (GO:0042737)5.17242302
19phosphate ion transport (GO:0006817)5.04679486
20tryptophan catabolic process (GO:0006569)5.01149516
21indole-containing compound catabolic process (GO:0042436)5.01149516
22indolalkylamine catabolic process (GO:0046218)5.01149516
23tryptophan metabolic process (GO:0006568)4.83701661
24regulation of apoptotic process involved in morphogenesis (GO:1902337)4.78520520
25negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.75953458
26aminoglycoside antibiotic metabolic process (GO:0030647)4.75042727
27response to mercury ion (GO:0046689)4.68608702
28kynurenine metabolic process (GO:0070189)4.58694571
29aspartate family amino acid catabolic process (GO:0009068)4.58184986
30serine family amino acid catabolic process (GO:0009071)4.56675819
31phosphate ion transmembrane transport (GO:0035435)4.54345821
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.54009303
33amino-acid betaine metabolic process (GO:0006577)4.52358785
34vitamin D metabolic process (GO:0042359)4.51486205
35sulfur amino acid catabolic process (GO:0000098)4.42042873
36short-chain fatty acid metabolic process (GO:0046459)4.39780414
37regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.38952261
38exogenous drug catabolic process (GO:0042738)4.38760240
39cellular modified amino acid catabolic process (GO:0042219)4.37871121
40quaternary ammonium group transport (GO:0015697)4.31448603
41tricarboxylic acid metabolic process (GO:0072350)4.25769319
42collecting duct development (GO:0072044)4.25333421
43mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.25193971
44valine metabolic process (GO:0006573)4.19541732
45actin filament depolymerization (GO:0030042)4.19196428
46regulation of nephron tubule epithelial cell differentiation (GO:0072182)4.12844741
47excretion (GO:0007588)4.11694609
48serine family amino acid metabolic process (GO:0009069)4.07218874
492-oxoglutarate metabolic process (GO:0006103)4.04612976
50regulation of bile acid biosynthetic process (GO:0070857)4.03638921
51flavonoid metabolic process (GO:0009812)4.03177264
52glutamate metabolic process (GO:0006536)4.01912806
53calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.00825304
54aromatic amino acid family metabolic process (GO:0009072)4.00207220
55glomerular visceral epithelial cell development (GO:0072015)3.99738391
56cellular glucuronidation (GO:0052695)3.97656498
57alpha-amino acid catabolic process (GO:1901606)3.92968497
58renal absorption (GO:0070293)3.91667642
59intestinal cholesterol absorption (GO:0030299)3.87215963
60branched-chain amino acid metabolic process (GO:0009081)3.84899519
61bile acid biosynthetic process (GO:0006699)3.83669966
62metanephric nephron tubule development (GO:0072234)3.81381765
63metanephric tubule development (GO:0072170)3.81381765
64cellular amino acid catabolic process (GO:0009063)3.81236105
65fatty acid beta-oxidation (GO:0006635)3.80523428
66uronic acid metabolic process (GO:0006063)3.72244990
67glucuronate metabolic process (GO:0019585)3.72244990
68regulation of complement activation (GO:0030449)3.72001671
69regulation of metanephros development (GO:0072215)3.71859547
70nephron tubule development (GO:0072080)3.71240312
71alpha-linolenic acid metabolic process (GO:0036109)3.71093557
72cellular ketone body metabolic process (GO:0046950)3.70700342
73regulation of protein activation cascade (GO:2000257)3.70699695
74metanephric nephron epithelium development (GO:0072243)3.68450251
75fatty acid oxidation (GO:0019395)3.68322713
76negative regulation of protein activation cascade (GO:2000258)3.68240134
77acetyl-CoA metabolic process (GO:0006084)3.66926810
78drug metabolic process (GO:0017144)3.66616922
79cardiovascular system development (GO:0072358)3.65620326
80negative regulation of complement activation (GO:0045916)3.61141126
81indolalkylamine metabolic process (GO:0006586)3.60418140
82lipid oxidation (GO:0034440)3.60060554
83epoxygenase P450 pathway (GO:0019373)3.59952963
84regulation of cholesterol homeostasis (GO:2000188)3.59802315
85regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.56713278
86carnitine metabolic process (GO:0009437)3.53695196
87regulation of mesenchymal cell apoptotic process (GO:2001053)3.52413753
88positive regulation of glomerulus development (GO:0090193)3.52020078
89amino-acid betaine transport (GO:0015838)3.50857841
90carnitine transport (GO:0015879)3.50857841
91transepithelial transport (GO:0070633)3.48663531
92serine family amino acid biosynthetic process (GO:0009070)3.47278606
93fatty acid catabolic process (GO:0009062)3.46061811
94glomerular epithelial cell development (GO:0072310)3.44039971
95omega-hydroxylase P450 pathway (GO:0097267)3.43750237
96organic acid catabolic process (GO:0016054)3.42741750
97carboxylic acid catabolic process (GO:0046395)3.42741750
98cell volume homeostasis (GO:0006884)3.41687190
99urea metabolic process (GO:0019627)3.41402457
100urea cycle (GO:0000050)3.41402457
101toxin transport (GO:1901998)3.41200807
102positive regulation of metanephros development (GO:0072216)3.39394654
103bile acid metabolic process (GO:0008206)3.37969015
104benzene-containing compound metabolic process (GO:0042537)3.37863014
105branched-chain amino acid catabolic process (GO:0009083)3.36541794
106nonribosomal peptide biosynthetic process (GO:0019184)3.36514557
107monocarboxylic acid catabolic process (GO:0072329)3.36267774
108metanephric epithelium development (GO:0072207)3.35542741
109renal tubule development (GO:0061326)3.33938250
110phosphate ion homeostasis (GO:0055062)3.27857260
111trivalent inorganic anion homeostasis (GO:0072506)3.27857260
112dicarboxylic acid biosynthetic process (GO:0043650)3.26677716
113tyrosine metabolic process (GO:0006570)3.25084467
114negative regulation of cholesterol transport (GO:0032375)3.20163831
115negative regulation of sterol transport (GO:0032372)3.20163831
116peptidyl-glutamic acid carboxylation (GO:0017187)3.19988189
117protein carboxylation (GO:0018214)3.19988189
118amine catabolic process (GO:0009310)3.19329677
119cellular biogenic amine catabolic process (GO:0042402)3.19329677
120glutathione biosynthetic process (GO:0006750)3.18933442
121nitrogen cycle metabolic process (GO:0071941)3.18742961
122regulation of stem cell maintenance (GO:2000036)3.18460704
123regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.16891114
124ketone body metabolic process (GO:1902224)3.15468460
125proline metabolic process (GO:0006560)3.13299495
126response to lead ion (GO:0010288)3.11709453
127response to phenylpropanoid (GO:0080184)3.09641216
128sphingoid metabolic process (GO:0046519)3.09458905
129peptide catabolic process (GO:0043171)3.06097061
130cell differentiation involved in metanephros development (GO:0072202)3.05264248
131nephron epithelium development (GO:0072009)3.05187007
132nephron epithelium morphogenesis (GO:0072088)3.04723141
133nephron tubule morphogenesis (GO:0072078)3.04723141
134response to growth hormone (GO:0060416)3.03695048
135biotin metabolic process (GO:0006768)3.03566523
136negative regulation of kidney development (GO:0090185)3.03406322
137response to water (GO:0009415)3.03088605
138regulation of hippo signaling (GO:0035330)3.02331581
139sodium-independent organic anion transport (GO:0043252)3.00779606
140positive regulation of catenin import into nucleus (GO:0035413)2.99084638
141coenzyme catabolic process (GO:0009109)2.98556981
142regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.98047525
143polyol transport (GO:0015791)2.96993613
144regulation of acrosome reaction (GO:0060046)2.94709666
145negative regulation of catenin import into nucleus (GO:0035414)2.94699999
146complement activation, alternative pathway (GO:0006957)2.92993983
147oxidative demethylation (GO:0070989)2.89418672
148indole-containing compound metabolic process (GO:0042430)2.88420552
149response to parathyroid hormone (GO:0071107)2.83150094
150embryonic retina morphogenesis in camera-type eye (GO:0060059)2.82711975
151xenobiotic catabolic process (GO:0042178)2.76626334
152bone remodeling (GO:0046849)2.76218414
153sphingosine metabolic process (GO:0006670)2.74305688
154positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.69154518
155endocrine hormone secretion (GO:0060986)2.65369206
156activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.64916557
157regulation of mesonephros development (GO:0061217)2.62074650
158negative regulation of humoral immune response (GO:0002921)2.58743480
159regulation of non-canonical Wnt signaling pathway (GO:2000050)2.57751685
160positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.56143389
161sulfation (GO:0051923)2.55849648
162mesonephros development (GO:0001823)2.52525012
163sodium ion homeostasis (GO:0055078)2.50980340
164lung lobe morphogenesis (GO:0060463)2.49454332

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.85254919
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.90267091
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.96554987
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.91941383
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.85994856
6NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.38271464
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.32408282
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.12769669
9GBX2_23144817_ChIP-Seq_PC3_Human3.11524376
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.73544880
11GATA1_22025678_ChIP-Seq_K562_Human2.58714282
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20811371
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.18733635
14CLOCK_20551151_ChIP-Seq_293T_Human2.06277723
15FOXA2_19822575_ChIP-Seq_HepG2_Human2.01380404
16RARG_19884340_ChIP-ChIP_MEFs_Mouse1.98519780
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.98416943
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.90850068
19SOX2_27498859_Chip-Seq_STOMACH_Mouse1.86400278
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85214566
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.84065082
22P300_19829295_ChIP-Seq_ESCs_Human1.76465660
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75440754
24* SMAD4_21799915_ChIP-Seq_A2780_Human1.74759015
25GATA4_25053715_ChIP-Seq_YYC3_Human1.71438721
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71360568
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70364477
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68969472
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65482012
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.59412996
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59340079
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59274883
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.55405940
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53334042
35* STAT3_23295773_ChIP-Seq_U87_Human1.53054927
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.51962743
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51083219
38* HNF4A_19822575_ChIP-Seq_HepG2_Human1.51010528
39IGF1R_20145208_ChIP-Seq_DFB_Human1.50904784
40TAF15_26573619_Chip-Seq_HEK293_Human1.50884036
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50784296
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46765416
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44161405
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.43623224
45* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41784896
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40375677
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39880439
48AR_21572438_ChIP-Seq_LNCaP_Human1.38860243
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38310064
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37415740
51* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37357337
52* TCF4_23295773_ChIP-Seq_U87_Human1.37028019
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37016032
54CBP_20019798_ChIP-Seq_JUKART_Human1.37016032
55EZH2_22144423_ChIP-Seq_EOC_Human1.36950324
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36268314
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.34733570
58TP53_16413492_ChIP-PET_HCT116_Human1.32395188
59TCF4_18268006_ChIP-ChIP_LS174T_Human1.31455047
60GATA6_25053715_ChIP-Seq_YYC3_Human1.30961260
61TCF4_22108803_ChIP-Seq_LS180_Human1.30679558
62AR_25329375_ChIP-Seq_VCAP_Human1.30630678
63* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30508135
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29970916
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28978479
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28978479
67ER_23166858_ChIP-Seq_MCF-7_Human1.27922206
68* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26723439
69SOX2_20726797_ChIP-Seq_SW620_Human1.26673844
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.25557687
71TP53_18474530_ChIP-ChIP_U2OS_Human1.24642218
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24313768
73* NFE2_27457419_Chip-Seq_LIVER_Mouse1.22158029
74* FLI1_27457419_Chip-Seq_LIVER_Mouse1.21817190
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20240749
76* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19316362
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18538815
78SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17375428
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16857714
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16361408
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15273497
82ZNF274_21170338_ChIP-Seq_K562_Hela1.14621313
83FUS_26573619_Chip-Seq_HEK293_Human1.14320428
84DROSHA_22980978_ChIP-Seq_HELA_Human1.14086280
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.13408278
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13088609
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12995138
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12686944
89* EZH2_27294783_Chip-Seq_NPCs_Mouse1.12554174
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11991369
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11664723
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11332787
93* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11116679
94* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11105942
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10261812
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10261812
97AR_21909140_ChIP-Seq_LNCAP_Human1.09953134
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09892865
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09500313
100* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08977167
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.08597186
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.08596176
103SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07696837
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06958552
105KDM2B_26808549_Chip-Seq_REH_Human1.06929535
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06682403
107VDR_22108803_ChIP-Seq_LS180_Human1.04320014
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02550409
109P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02209348
110* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01906173
111TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01412511
112AHR_22903824_ChIP-Seq_MCF-7_Human1.01017606
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00667509
114TBL1_22424771_ChIP-Seq_293T_Human0.99710425
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99465059
116CJUN_26792858_Chip-Seq_BT549_Human0.98804879
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98063541
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.97863670
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96244836
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.95333125
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94898410
122* TBX20_22328084_ChIP-Seq_HEART_Mouse0.94451799
123* TBX20_22080862_ChIP-Seq_HEART_Mouse0.94451799
124Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94010934
125SMAD3_21741376_ChIP-Seq_HESCs_Human0.93249866
126CDX2_22108803_ChIP-Seq_LS180_Human0.92735363
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92239266
128TP63_23658742_ChIP-Seq_EP156T_Human0.91705047
129* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91222730
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89913189
131SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89207532
132GATA2_21666600_ChIP-Seq_HMVEC_Human0.88517321
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.88085003
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.87435894
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85145323
136EGR1_19032775_ChIP-ChIP_M12_Human0.82470906
137FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79467580
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78044448
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77371414
140BCAT_22108803_ChIP-Seq_LS180_Human0.73505284
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73350344
142RXR_22108803_ChIP-Seq_LS180_Human0.73174578
143RACK7_27058665_Chip-Seq_MCF-7_Human0.72448583
144GATA2_19941826_ChIP-Seq_K562_Human0.71740714
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.69646130
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.69540176
147GATA1_19941826_ChIP-Seq_K562_Human0.68805187
148* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.68120235
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67610447
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67244375
151STAT1_17558387_ChIP-Seq_HELA_Human0.66334479
152* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66150980
153NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64984889
154CBP_21632823_ChIP-Seq_H3396_Human0.64833699
155P63_26484246_Chip-Seq_KERATINOCYTES_Human0.62313178
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.60812502
157MYC_19915707_ChIP-ChIP_AK7_Human0.57919076
158GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.57596047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.04527058
2MP0005360_urolithiasis6.69462258
3MP0005365_abnormal_bile_salt4.71403454
4MP0003195_calcinosis4.69592490
5MP0005085_abnormal_gallbladder_physiolo3.94911210
6MP0004043_abnormal_pH_regulation3.75616625
7* MP0003252_abnormal_bile_duct3.74037973
8MP0005332_abnormal_amino_acid3.69762002
9MP0004019_abnormal_vitamin_homeostasis3.63540404
10* MP0002138_abnormal_hepatobiliary_system3.51279909
11MP0008875_abnormal_xenobiotic_pharmacok3.32351656
12MP0005084_abnormal_gallbladder_morpholo3.25491868
13MP0009643_abnormal_urine_homeostasis2.96218008
14MP0001666_abnormal_nutrient_absorption2.71323454
15MP0005083_abnormal_biliary_tract2.63141567
16MP0001756_abnormal_urination2.44823887
17* MP0002928_abnormal_bile_duct2.38572899
18MP0001765_abnormal_ion_homeostasis2.31983010
19MP0003879_abnormal_hair_cell2.30527465
20MP0005636_abnormal_mineral_homeostasis2.11480343
21MP0002136_abnormal_kidney_physiology2.08814678
22MP0003806_abnormal_nucleotide_metabolis1.84961816
23MP0001958_emphysema1.82650069
24MP0010329_abnormal_lipoprotein_level1.76363621
25* MP0005220_abnormal_exocrine_pancreas1.74292219
26MP0003868_abnormal_feces_composition1.63829008
27MP0004264_abnormal_extraembryonic_tissu1.56714168
28MP0000534_abnormal_ureter_morphology1.55018270
29MP0003136_yellow_coat_color1.54564311
30MP0010234_abnormal_vibrissa_follicle1.54098002
31MP0002132_abnormal_respiratory_system1.44619983
32MP0002118_abnormal_lipid_homeostasis1.39575596
33MP0002163_abnormal_gland_morphology1.36998006
34MP0002876_abnormal_thyroid_physiology1.35493147
35MP0000538_abnormal_urinary_bladder1.33325071
36MP0005319_abnormal_enzyme/_coenzyme1.31263169
37MP0000609_abnormal_liver_physiology1.30376492
38MP0005377_hearing/vestibular/ear_phenot1.29238634
39MP0003878_abnormal_ear_physiology1.29238634
40MP0008872_abnormal_physiological_respon1.28682119
41MP0008961_abnormal_basal_metabolism1.23297291
42MP0003191_abnormal_cellular_cholesterol1.19486997
43MP0005584_abnormal_enzyme/coenzyme_acti1.19150848
44MP0003705_abnormal_hypodermis_morpholog1.12889917
45MP0004272_abnormal_basement_membrane1.12801415
46MP0003646_muscle_fatigue1.12309779
47MP0003283_abnormal_digestive_organ1.08263781
48MP0005451_abnormal_body_composition1.08135662
49MP0003186_abnormal_redox_activity1.06734698
50MP0000383_abnormal_hair_follicle1.05330673
51MP0009780_abnormal_chondrocyte_physiolo1.05077918
52* MP0002168_other_aberrant_phenotype1.05001852
53MP0005058_abnormal_lysosome_morphology1.02265322
54MP0001661_extended_life_span1.01806944
55MP0001764_abnormal_homeostasis0.99481531
56MP0003959_abnormal_lean_body0.97773418
57MP0005410_abnormal_fertilization0.96527203
58MP0005379_endocrine/exocrine_gland_phen0.95773336
59MP0002837_dystrophic_cardiac_calcinosis0.95682749
60MP0002896_abnormal_bone_mineralization0.91836467
61MP0005670_abnormal_white_adipose0.89650210
62MP0000462_abnormal_digestive_system0.87573225
63MP0010368_abnormal_lymphatic_system0.87485936
64* MP0002135_abnormal_kidney_morphology0.87069154
65MP0005171_absent_coat_pigmentation0.85117680
66MP0001501_abnormal_sleep_pattern0.85110278
67MP0003890_abnormal_embryonic-extraembry0.84035126
68* MP0001944_abnormal_pancreas_morphology0.83244496
69MP0003950_abnormal_plasma_membrane0.82362271
70MP0009384_cardiac_valve_regurgitation0.81862002
71MP0003638_abnormal_response/metabolism_0.80287734
72MP0002078_abnormal_glucose_homeostasis0.80118761
73MP0005408_hypopigmentation0.79018235
74* MP0003943_abnormal_hepatobiliary_system0.78938437
75* MP0000598_abnormal_liver_morphology0.78866838
76MP0000230_abnormal_systemic_arterial0.75078710
77MP0009642_abnormal_blood_homeostasis0.73727176
78MP0010386_abnormal_urinary_bladder0.72453842
79MP0001485_abnormal_pinna_reflex0.70435993
80MP0002796_impaired_skin_barrier0.70082933
81MP0002277_abnormal_respiratory_mucosa0.69579519
82MP0003183_abnormal_peptide_metabolism0.67385392
83* MP0003300_gastrointestinal_ulcer0.67349410
84MP0009764_decreased_sensitivity_to0.66492040
85MP0005666_abnormal_adipose_tissue0.65917051
86MP0005535_abnormal_body_temperature0.65819801
87MP0009840_abnormal_foam_cell0.64051009
88MP0000566_synostosis0.63327925
89MP0005647_abnormal_sex_gland0.60762890
90* MP0005395_other_phenotype0.60576176
91MP0003941_abnormal_skin_development0.59187300
92MP0003953_abnormal_hormone_level0.54967922
93MP0004885_abnormal_endolymph0.54004430
94MP0008057_abnormal_DNA_replication0.53548522
95MP0001984_abnormal_olfaction0.52222891
96MP0000013_abnormal_adipose_tissue0.50932196
97MP0006276_abnormal_autonomic_nervous0.50701539
98MP0008469_abnormal_protein_level0.49402116
99MP0005165_increased_susceptibility_to0.48952384
100* MP0003045_fibrosis0.48748077
101MP0006036_abnormal_mitochondrial_physio0.48180855
102MP0000026_abnormal_inner_ear0.48040311
103MP0005375_adipose_tissue_phenotype0.47580375
104MP0001486_abnormal_startle_reflex0.45369607
105MP0003938_abnormal_ear_development0.45249030
106MP0001963_abnormal_hearing_physiology0.44558724
107MP0002089_abnormal_postnatal_growth/wei0.44215923
108MP0003566_abnormal_cell_adhesion0.43623237
109MP0000427_abnormal_hair_cycle0.43463542
110MP0008004_abnormal_stomach_pH0.43372229
111MP0002693_abnormal_pancreas_physiology0.43155404
112MP0002295_abnormal_pulmonary_circulatio0.42744361
113MP0005501_abnormal_skin_physiology0.42301794
114MP0002069_abnormal_eating/drinking_beha0.42115109
115MP0009703_decreased_birth_body0.41726163
116MP0002098_abnormal_vibrissa_morphology0.41661258
117MP0001270_distended_abdomen0.40384039
118MP0003172_abnormal_lysosome_physiology0.40190478
119MP0000003_abnormal_adipose_tissue0.39381048
120MP0001346_abnormal_lacrimal_gland0.38957713
121MP0000613_abnormal_salivary_gland0.38943519
122MP0006054_spinal_hemorrhage0.38813149
123MP0005275_abnormal_skin_tensile0.38666090
124MP0004133_heterotaxia0.38089990
125MP0005646_abnormal_pituitary_gland0.37605665
126MP0009672_abnormal_birth_weight0.37389119
127MP0010678_abnormal_skin_adnexa0.36950515
128MP0000631_abnormal_neuroendocrine_gland0.36362127
129MP0004085_abnormal_heartbeat0.35514898
130MP0002254_reproductive_system_inflammat0.35194029
131MP0004233_abnormal_muscle_weight0.35120215
132MP0001664_abnormal_digestion0.34127272
133MP0005334_abnormal_fat_pad0.34056262
134MP0009763_increased_sensitivity_to0.33699067
135MP0005595_abnormal_vascular_smooth0.33138648
136MP0002971_abnormal_brown_adipose0.33057272
137MP0002108_abnormal_muscle_morphology0.31568431
138MP0002697_abnormal_eye_size0.30726626

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)7.68442156
2Increased circulating renin level (HP:0000848)6.48283426
3Hypokalemic alkalosis (HP:0001949)6.08064987
4Metabolic alkalosis (HP:0200114)5.89126559
5Hyperactive renin-angiotensin system (HP:0000841)5.62392695
6Hypomagnesemia (HP:0002917)5.48091447
7Polyuria (HP:0000103)5.20235422
8Abnormality of chloride homeostasis (HP:0011422)5.17635424
9Abnormal urine output (HP:0012590)5.02586697
10Increased purine levels (HP:0004368)4.97897881
11Hyperuricemia (HP:0002149)4.97897881
12Abnormality of renal excretion (HP:0011036)4.83955404
13Proximal tubulopathy (HP:0000114)4.70052349
14Abnormality of purine metabolism (HP:0004352)4.61980136
15Abnormality of glutamine family amino acid metabolism (HP:0010902)4.52395039
16Abnormality of magnesium homeostasis (HP:0004921)4.47821110
17Alkalosis (HP:0001948)4.34926154
18Hyperglycinuria (HP:0003108)4.26223633
19Tetany (HP:0001281)4.21748286
20Polydipsia (HP:0001959)4.10432591
21Abnormal drinking behavior (HP:0030082)4.10432591
22Ketoacidosis (HP:0001993)3.98513047
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.96672355
24Renal salt wasting (HP:0000127)3.91056481
25Abnormality of renin-angiotensin system (HP:0000847)3.87968702
26Hyperaldosteronism (HP:0000859)3.79524215
27Ketosis (HP:0001946)3.71159281
28Abnormality of glycine metabolism (HP:0010895)3.62193930
29Abnormality of serine family amino acid metabolism (HP:0010894)3.62193930
30Abnormality of nucleobase metabolism (HP:0010932)3.60564064
31Abnormality of urine glucose concentration (HP:0011016)3.49093981
32Glycosuria (HP:0003076)3.49093981
33Intrahepatic cholestasis (HP:0001406)3.41081495
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.38928906
35Hypokalemia (HP:0002900)3.31357121
36Generalized aminoaciduria (HP:0002909)3.25026690
37Adrenal overactivity (HP:0002717)3.19866235
38Abnormality of monocarboxylic acid metabolism (HP:0010996)3.18113154
39Hypoglycemic coma (HP:0001325)3.11582845
40Xanthomatosis (HP:0000991)3.07453995
41Hyperglycinemia (HP:0002154)3.04263720
42Abnormality of fatty-acid metabolism (HP:0004359)3.04262036
43Abnormality of sulfur amino acid metabolism (HP:0004339)3.04096990
44Renal tubular acidosis (HP:0001947)3.03168786
45Hypercalciuria (HP:0002150)3.01791276
46Hyperammonemia (HP:0001987)2.97383299
47Late onset (HP:0003584)2.95752221
48Vascular calcification (HP:0004934)2.82004407
49Cardiovascular calcification (HP:0011915)2.79537715
50Deep venous thrombosis (HP:0002625)2.75744340
51Abnormality of potassium homeostasis (HP:0011042)2.73889111
52Nephrolithiasis (HP:0000787)2.64649370
53Abnormality of proline metabolism (HP:0010907)2.60111149
54Hydroxyprolinuria (HP:0003080)2.60111149
55Delayed CNS myelination (HP:0002188)2.53605779
56Bicornuate uterus (HP:0000813)2.50655623
57Nephrocalcinosis (HP:0000121)2.50190511
58Rickets (HP:0002748)2.47796072
59Hyperphosphaturia (HP:0003109)2.46703868
60Glomerulosclerosis (HP:0000096)2.46589606
61Fat malabsorption (HP:0002630)2.42057392
62Abnormal pancreas size (HP:0012094)2.38965564
63Abnormal enzyme/coenzyme activity (HP:0012379)2.35648921
64Hypophosphatemia (HP:0002148)2.32962506
65Ileus (HP:0002595)2.31855257
66Abnormal urine phosphate concentration (HP:0012599)2.28332638
67Exocrine pancreatic insufficiency (HP:0001738)2.23563158
68Confusion (HP:0001289)2.23079075
69Abnormality of alkaline phosphatase activity (HP:0004379)2.21388828
70Conjugated hyperbilirubinemia (HP:0002908)2.19744161
71Hypoglycemic seizures (HP:0002173)2.19479014
72Metabolic acidosis (HP:0001942)2.17346689
73Focal segmental glomerulosclerosis (HP:0000097)2.16308782
74Malnutrition (HP:0004395)2.14592336
75Unilateral renal agenesis (HP:0000122)2.13913578
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13298432
77Dicarboxylic aciduria (HP:0003215)2.13298432
78* Dehydration (HP:0001944)2.12603943
79Hepatocellular carcinoma (HP:0001402)2.11351316
80Amelogenesis imperfecta (HP:0000705)2.11295898
81* Facial shape deformation (HP:0011334)2.10123963
82* Potter facies (HP:0002009)2.10123963
83Hypothermia (HP:0002045)2.08587612
84Decreased circulating renin level (HP:0003351)2.06634440
85Hypotension (HP:0002615)2.05345789
86* Enlarged kidneys (HP:0000105)2.02032377
87Hyperinsulinemic hypoglycemia (HP:0000825)2.01713218
88Widely patent fontanelles and sutures (HP:0004492)2.01489521
89Symptomatic seizures (HP:0011145)1.99946929
90Thin bony cortex (HP:0002753)1.99602388
91Tubular atrophy (HP:0000092)1.98267130
92Vomiting (HP:0002013)1.98265757
93Chondrocalcinosis (HP:0000934)1.97674139
94Joint hemorrhage (HP:0005261)1.96389435
95Rectal prolapse (HP:0002035)1.95964332
96Abnormality of the common coagulation pathway (HP:0010990)1.93761062
97Sensorimotor neuropathy (HP:0007141)1.92140532
98Lethargy (HP:0001254)1.91708202
99Lymphangioma (HP:0100764)1.91032717
100Abnormality of serum amino acid levels (HP:0003112)1.90465728
101Prolonged partial thromboplastin time (HP:0003645)1.88318461
102Vacuolated lymphocytes (HP:0001922)1.87163483
103Irritability (HP:0000737)1.87030890
104Generalized muscle weakness (HP:0003324)1.85732973
105Abnormality of Sharpey fibers (HP:0100685)1.85700763
106Abnormality of macular pigmentation (HP:0008002)1.85089418
107Large eyes (HP:0001090)1.84346629
108Complement deficiency (HP:0004431)1.84249146
109Stage 5 chronic kidney disease (HP:0003774)1.83962300
110Steatorrhea (HP:0002570)1.83721537
111Abnormality of sodium homeostasis (HP:0010931)1.81559370
112Delayed epiphyseal ossification (HP:0002663)1.80981092
113Mitral stenosis (HP:0001718)1.79302630
114Hyponatremia (HP:0002902)1.77392139
115Bilateral sensorineural hearing impairment (HP:0008619)1.77168077
116Spastic diplegia (HP:0001264)1.76693850
117Hyperkalemia (HP:0002153)1.75361484
118Thyroid-stimulating hormone excess (HP:0002925)1.72991740
119Male infertility (HP:0003251)1.55012369
120Fair hair (HP:0002286)1.54086982
121Glomerulonephritis (HP:0000099)1.51287262
122Abnormality of complement system (HP:0005339)1.47802970
123* Abnormality of the renal medulla (HP:0100957)1.45372125
124Hypoplastic labia majora (HP:0000059)1.42503770
125Abnormality of the labia majora (HP:0012881)1.39384537
126Osteomalacia (HP:0002749)1.39317657
127Visceral angiomatosis (HP:0100761)1.38854704
128Nephritis (HP:0000123)1.38486643
129Hypophosphatemic rickets (HP:0004912)1.32752313
130Hemangiomatosis (HP:0007461)1.31271630
131Chorioretinal atrophy (HP:0000533)1.27920746
132Congenital sensorineural hearing impairment (HP:0008527)1.27605973
133Popliteal pterygium (HP:0009756)1.27465466
134Nephrogenic diabetes insipidus (HP:0009806)1.23568986
135Impaired platelet aggregation (HP:0003540)1.23194901
136Abnormal platelet function (HP:0011869)1.23194901
137Hypoplasia of the uterus (HP:0000013)1.22780962
138Abnormal biliary tract morphology (HP:0012440)1.19082604
139Renal hypoplasia (HP:0000089)1.18585797
140Abnormality of the dental pulp (HP:0006479)1.15923529
141Taurodontia (HP:0000679)1.15358970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK37.66787475
2WNK46.57286751
3OXSR15.67645656
4STK393.14871765
5BCKDK3.02612214
6INSRR2.67683280
7FRK2.40015856
8STK38L2.29533329
9FGFR42.20847039
10LATS12.00735304
11MAPK151.97901684
12MST1R1.92482418
13ERN11.61342571
14SGK2231.49777570
15SGK4941.49777570
16SIK11.47538582
17TAOK31.45751139
18PTK61.39731469
19ERBB41.36224502
20BMPR1B1.35616339
21PTK21.26600267
22SGK31.24103655
23PIK3CG1.22991652
24WNK11.22148938
25LATS21.21499085
26DYRK1B1.21419927
27SGK21.14124291
28NLK1.12393834
29MST41.11689460
30ACVR1B1.11246668
31EPHB11.11207820
32RIPK11.10827921
33FGFR21.05776025
34EPHA21.03082985
35STK380.96488424
36PDK40.92910461
37PDK30.92910461
38MET0.90465705
39MAP3K20.90361917
40FER0.89825371
41GSK3A0.89269518
42LRRK20.88765342
43MAP3K70.86755831
44TRIB30.76508073
45PRKAA20.75826743
46TGFBR20.75811068
47NEK90.72980690
48TNIK0.72439558
49PAK40.70703632
50CAMK1D0.67042248
51NTRK30.66872619
52TIE10.66839860
53PRKAA10.63734843
54PDGFRA0.62865587
55MELK0.62728825
56PDK20.59721224
57MAPK110.59454829
58AKT30.59156858
59PIK3CA0.58995086
60LMTK20.58921319
61PAK30.58411768
62PRKD20.58036767
63MAP3K30.56343684
64PRKD30.54279886
65ERBB20.54184403
66GRK10.53769506
67ADRBK20.53265825
68CAMK1G0.51961673
69STK100.51957213
70MAP4K20.51296614
71MTOR0.51209691
72PRKCZ0.50790774
73FGFR30.49028202
74SGK10.45597919
75PRKCI0.44992657
76JAK20.44461975
77STK30.43932595
78STK240.42162362
79TGFBR10.41542942
80ABL20.39819979
81PINK10.39238881
82NTRK10.38759234
83DDR20.38681850
84TTN0.38572784
85BCR0.37951792
86MAP3K140.37782705
87PKN20.35546621
88BRD40.34164113
89PRKCH0.34062267
90PDPK10.33504672
91EIF2AK30.32499796
92MAP2K20.31766935
93EPHB20.31514376
94TRPM70.30710338
95CSK0.29064210
96CSNK1A10.28977562
97MAP2K10.28771449
98DAPK20.26760840
99BMX0.26746656
100CSNK1A1L0.26387225
101IRAK30.26316265
102PRKACG0.26314567
103NEK10.26163554
104IGF1R0.26056464
105FGFR10.26048635
106PRKACA0.23767607
107JAK10.23628388
108CHUK0.22939424
109PASK0.22536267
110BRSK20.22451537
111PRKG10.21842763
112CASK0.21365626
113KDR0.21303617
114CSNK1G10.21104784
115ROCK10.20385936
116NUAK10.19660275
117SCYL20.19361926
118MARK20.19230947
119ADRBK10.19183358
120PDGFRB0.18348120
121INSR0.18144838
122NME10.17686661
123MYLK0.17569957
124PRKCA0.17422194
125ABL10.17081822
126PRKG20.15659574
127EGFR0.15548524
128ZAK0.14927835
129PRKCQ0.14922907
130MAPKAPK30.14815558
131PRKCE0.14796030
132MKNK20.14434106
133PRKCG0.14281180
134MAP3K40.13899215
135PRKACB0.13177812
136PRKD10.13108236
137CSNK1D0.12449042
138TNK20.12095394
139STK110.11102003
140PDK10.10998028
141RPS6KA30.10913609
142KIT0.10878409
143PRKCB0.08753258
144IKBKB0.08109471
145EPHA30.07898162
146MAPK10.07334243

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12693449
2Nitrogen metabolism_Homo sapiens_hsa009102.90234387
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83205547
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.82873841
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.75843177
6Butanoate metabolism_Homo sapiens_hsa006502.74352226
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68439226
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.61447323
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.55213566
10Tryptophan metabolism_Homo sapiens_hsa003802.54393627
11Fatty acid degradation_Homo sapiens_hsa000712.50052342
12Propanoate metabolism_Homo sapiens_hsa006402.48488610
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38032026
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24091147
15Arginine biosynthesis_Homo sapiens_hsa002202.21516889
16Peroxisome_Homo sapiens_hsa041462.20570251
17Cyanoamino acid metabolism_Homo sapiens_hsa004602.19702973
18Vitamin digestion and absorption_Homo sapiens_hsa049772.11958037
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07170616
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06371398
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02598845
22Bile secretion_Homo sapiens_hsa049761.84753105
23Sulfur metabolism_Homo sapiens_hsa009201.81056601
24Fatty acid metabolism_Homo sapiens_hsa012121.79458790
25Pyruvate metabolism_Homo sapiens_hsa006201.72588583
26beta-Alanine metabolism_Homo sapiens_hsa004101.70227231
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.69496377
28Protein digestion and absorption_Homo sapiens_hsa049741.64882071
29PPAR signaling pathway_Homo sapiens_hsa033201.58737188
30Selenocompound metabolism_Homo sapiens_hsa004501.56305023
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56209677
32Histidine metabolism_Homo sapiens_hsa003401.45850179
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.42954351
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37977541
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37643933
36Complement and coagulation cascades_Homo sapiens_hsa046101.35460614
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35311118
38Starch and sucrose metabolism_Homo sapiens_hsa005001.35157113
39Lysine degradation_Homo sapiens_hsa003101.31295948
40Carbon metabolism_Homo sapiens_hsa012001.23081572
41Fat digestion and absorption_Homo sapiens_hsa049751.22712688
42ABC transporters_Homo sapiens_hsa020101.19091338
43Phenylalanine metabolism_Homo sapiens_hsa003601.18613432
44Chemical carcinogenesis_Homo sapiens_hsa052041.17255695
45Glycerolipid metabolism_Homo sapiens_hsa005611.15466797
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13484443
47Dorso-ventral axis formation_Homo sapiens_hsa043201.13313704
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.08485237
49Arginine and proline metabolism_Homo sapiens_hsa003301.07874334
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06292563
51Folate biosynthesis_Homo sapiens_hsa007901.04891732
52Glutathione metabolism_Homo sapiens_hsa004801.03007156
53Circadian rhythm_Homo sapiens_hsa047101.02128512
54Steroid biosynthesis_Homo sapiens_hsa001001.00228075
55Biosynthesis of amino acids_Homo sapiens_hsa012300.97318389
56Pancreatic secretion_Homo sapiens_hsa049720.92349089
57Retinol metabolism_Homo sapiens_hsa008300.88427094
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.86401525
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.85298337
60Fatty acid elongation_Homo sapiens_hsa000620.83445266
61Tyrosine metabolism_Homo sapiens_hsa003500.78308166
62Mineral absorption_Homo sapiens_hsa049780.74184398
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73859739
64Renin-angiotensin system_Homo sapiens_hsa046140.72629848
65Collecting duct acid secretion_Homo sapiens_hsa049660.70218556
66Phototransduction_Homo sapiens_hsa047440.70069455
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67385571
68Other glycan degradation_Homo sapiens_hsa005110.65984953
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64450647
70Caffeine metabolism_Homo sapiens_hsa002320.60099037
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58335502
72Ether lipid metabolism_Homo sapiens_hsa005650.55620006
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53088113
74Staphylococcus aureus infection_Homo sapiens_hsa051500.53069008
75Ovarian steroidogenesis_Homo sapiens_hsa049130.50381155
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45760449
77Thyroid hormone synthesis_Homo sapiens_hsa049180.44997288
78Hepatitis C_Homo sapiens_hsa051600.43837094
79Taste transduction_Homo sapiens_hsa047420.42893275
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41463694
81Metabolic pathways_Homo sapiens_hsa011000.40565964
82TGF-beta signaling pathway_Homo sapiens_hsa043500.40550931
83Serotonergic synapse_Homo sapiens_hsa047260.39349613
84Pentose phosphate pathway_Homo sapiens_hsa000300.38643154
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38532709
86ECM-receptor interaction_Homo sapiens_hsa045120.37016217
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36544798
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.35911960
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.34775391
90Insulin resistance_Homo sapiens_hsa049310.33891880
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33119147
92Lysosome_Homo sapiens_hsa041420.32826254
93Salivary secretion_Homo sapiens_hsa049700.27896262
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.27290487
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26740256
96Nicotine addiction_Homo sapiens_hsa050330.26091738
97Bladder cancer_Homo sapiens_hsa052190.25543580
98Fructose and mannose metabolism_Homo sapiens_hsa000510.24055459
99N-Glycan biosynthesis_Homo sapiens_hsa005100.23862806
100Insulin secretion_Homo sapiens_hsa049110.23209011
101cAMP signaling pathway_Homo sapiens_hsa040240.21217375
102Melanoma_Homo sapiens_hsa052180.20778597
103Renin secretion_Homo sapiens_hsa049240.20723552
104One carbon pool by folate_Homo sapiens_hsa006700.20527829
105FoxO signaling pathway_Homo sapiens_hsa040680.20271984
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19606325
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17111791
108Glucagon signaling pathway_Homo sapiens_hsa049220.16673218
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.16614907
110Inositol phosphate metabolism_Homo sapiens_hsa005620.16297559
111Sulfur relay system_Homo sapiens_hsa041220.16183787
112GABAergic synapse_Homo sapiens_hsa047270.15168781
113Type II diabetes mellitus_Homo sapiens_hsa049300.14911415
114Prostate cancer_Homo sapiens_hsa052150.14459181
115Calcium signaling pathway_Homo sapiens_hsa040200.13772779
116AMPK signaling pathway_Homo sapiens_hsa041520.10263662
117Gastric acid secretion_Homo sapiens_hsa049710.10229724
118Adherens junction_Homo sapiens_hsa045200.09781452
119Focal adhesion_Homo sapiens_hsa045100.09643471
120Tight junction_Homo sapiens_hsa045300.09231430
121Choline metabolism in cancer_Homo sapiens_hsa052310.04417170
122Arachidonic acid metabolism_Homo sapiens_hsa005900.04299139
123Galactose metabolism_Homo sapiens_hsa000520.02404432
124Fatty acid biosynthesis_Homo sapiens_hsa000610.02161717
125Amoebiasis_Homo sapiens_hsa051460.01594704
126Sphingolipid metabolism_Homo sapiens_hsa006000.01053508
127Vitamin B6 metabolism_Homo sapiens_hsa007500.00747238
128Linoleic acid metabolism_Homo sapiens_hsa00591-0.0041256
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0029604

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