PKHD1L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)9.62537851
2tetrapyrrole biosynthetic process (GO:0033014)9.30379320
3erythrocyte maturation (GO:0043249)7.98713252
4porphyrin-containing compound metabolic process (GO:0006778)7.89021856
5hemoglobin metabolic process (GO:0020027)7.47315317
6heme metabolic process (GO:0042168)7.21520234
7thrombin receptor signaling pathway (GO:0070493)6.33284844
8response to methylmercury (GO:0051597)5.96584495
9low-density lipoprotein particle clearance (GO:0034383)5.76176820
10erythrocyte development (GO:0048821)5.57295393
11regulation of platelet activation (GO:0010543)5.56205329
12angiogenesis involved in wound healing (GO:0060055)5.24815525
13regulation of platelet aggregation (GO:0090330)5.24666333
14neutrophil activation involved in immune response (GO:0002283)5.22770921
15ovulation from ovarian follicle (GO:0001542)5.17871889
16negative regulation of platelet activation (GO:0010544)5.08328962
17blood coagulation, intrinsic pathway (GO:0007597)5.06359632
18tetrapyrrole metabolic process (GO:0033013)5.00825826
19platelet aggregation (GO:0070527)4.80856766
20erythrocyte differentiation (GO:0030218)4.75724412
21regulation of integrin-mediated signaling pathway (GO:2001044)4.74047737
22iron ion import (GO:0097286)4.71582046
23response to insecticide (GO:0017085)4.68864679
24positive regulation of endothelial cell differentiation (GO:0045603)4.66980666
25protein neddylation (GO:0045116)4.60673080
26response to lead ion (GO:0010288)4.59582358
27negative regulation of homotypic cell-cell adhesion (GO:0034111)4.58718694
28positive regulation of receptor recycling (GO:0001921)4.45738938
29regulation of lipoprotein metabolic process (GO:0050746)4.40689193
30thyroid hormone generation (GO:0006590)4.25983131
31gas transport (GO:0015669)4.12457721
32leukocyte migration involved in inflammatory response (GO:0002523)4.04379689
33platelet degranulation (GO:0002576)3.97587020
34regulation of integrin activation (GO:0033623)3.96495839
35fatty acid transmembrane transport (GO:1902001)3.94091085
36myeloid cell development (GO:0061515)3.91751968
37one-carbon compound transport (GO:0019755)3.89419329
38adenosine receptor signaling pathway (GO:0001973)3.89308982
39positive regulation of insulin receptor signaling pathway (GO:0046628)3.82228178
40positive regulation of cardiac muscle hypertrophy (GO:0010613)3.80871875
41positive regulation of muscle hypertrophy (GO:0014742)3.80871875
42response to arsenic-containing substance (GO:0046685)3.80525396
43negative regulation of norepinephrine secretion (GO:0010700)3.78675233
44thyroid hormone metabolic process (GO:0042403)3.77704801
45regulation of response to osmotic stress (GO:0047484)3.77627402
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.74313070
47extracellular fibril organization (GO:0043206)3.72184777
48pigment biosynthetic process (GO:0046148)3.69305917
49positive regulation of hemostasis (GO:1900048)3.63376226
50positive regulation of blood coagulation (GO:0030194)3.63376226
51embryonic hemopoiesis (GO:0035162)3.62946712
52carnitine shuttle (GO:0006853)3.62049580
53positive regulation of mast cell activation (GO:0033005)3.59124738
54ovulation (GO:0030728)3.57876388
55brown fat cell differentiation (GO:0050873)3.56999078
56positive regulation of fatty acid beta-oxidation (GO:0032000)3.56181176
57regulation of sequestering of triglyceride (GO:0010889)3.54383952
58G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.53931528
59endothelium development (GO:0003158)3.53082933
60positive regulation of cellular response to insulin stimulus (GO:1900078)3.52441347
61triglyceride catabolic process (GO:0019433)3.51702524
62regulation of endothelial cell differentiation (GO:0045601)3.50337783
63carnitine transmembrane transport (GO:1902603)3.46620009
64definitive hemopoiesis (GO:0060216)3.44914316
65fibril organization (GO:0097435)3.41977079
66valine metabolic process (GO:0006573)3.39025023
67bicarbonate transport (GO:0015701)3.35142349
68regulation of macrophage derived foam cell differentiation (GO:0010743)3.34470064
69import into cell (GO:0098657)3.34426248
70negative regulation of protein localization to cell surface (GO:2000009)3.33775143
71cytoskeletal anchoring at plasma membrane (GO:0007016)3.33449963
72platelet activation (GO:0030168)3.30478432
73positive regulation of coagulation (GO:0050820)3.29572950
74white fat cell differentiation (GO:0050872)3.29129605
75regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.29116692
76positive regulation of systemic arterial blood pressure (GO:0003084)3.28101888
77negative regulation of stress fiber assembly (GO:0051497)3.26071421
78very-low-density lipoprotein particle assembly (GO:0034379)3.25493703
79positive regulation of histone deacetylation (GO:0031065)3.24354388
80homotypic cell-cell adhesion (GO:0034109)3.22336040
81positive regulation of fatty acid oxidation (GO:0046321)3.21146344
82regulation of cholesterol storage (GO:0010885)3.21017388
83response to folic acid (GO:0051593)3.15949904
84fatty acid homeostasis (GO:0055089)3.13514773
85amino-acid betaine transport (GO:0015838)3.13466412
86carnitine transport (GO:0015879)3.13466412
87actin filament capping (GO:0051693)3.11489359
88negative regulation of granulocyte differentiation (GO:0030853)3.10499217
89regulation of female receptivity (GO:0045924)3.06926968
90platelet formation (GO:0030220)3.06532970
91acylglycerol catabolic process (GO:0046464)3.05343495
92neutral lipid catabolic process (GO:0046461)3.05343495
93embryonic retina morphogenesis in camera-type eye (GO:0060059)3.05284429
94negative regulation of heart rate (GO:0010459)3.03373291
95neutrophil activation (GO:0042119)3.03149759
96regulation of blood coagulation (GO:0030193)3.03051441
97regulation of hemostasis (GO:1900046)3.03051441
98regulation of Golgi to plasma membrane protein transport (GO:0042996)3.02840527
99regulation of homotypic cell-cell adhesion (GO:0034110)3.02027339
100positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00084713
101regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.98702668
102low-density lipoprotein particle remodeling (GO:0034374)2.98615945
103negative regulation of thymocyte apoptotic process (GO:0070244)2.97047551
104negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.96491993
105negative regulation of T-helper cell differentiation (GO:0045623)2.96491993
106DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.93831425
107fusion of sperm to egg plasma membrane (GO:0007342)2.93788619
108negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93044721
109regulation of receptor recycling (GO:0001919)2.92614315
110negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.91697421
111pigment metabolic process (GO:0042440)2.91137089
112bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90266270
113mesodermal cell differentiation (GO:0048333)2.89528696
114purinergic nucleotide receptor signaling pathway (GO:0035590)2.87929902
115positive regulation of macrophage differentiation (GO:0045651)2.86637742
116positive regulation of Rho protein signal transduction (GO:0035025)2.85064506
117fibroblast migration (GO:0010761)2.84904459
118positive regulation of macrophage cytokine production (GO:0060907)2.84131034
119cellular response to epinephrine stimulus (GO:0071872)2.83674068
120lipoxygenase pathway (GO:0019372)2.82601236
121regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81683024
122regulation of cardiac muscle hypertrophy (GO:0010611)2.81016682
123positive regulation of p38MAPK cascade (GO:1900745)2.80377517
124plasma lipoprotein particle assembly (GO:0034377)2.78955559
125relaxation of smooth muscle (GO:0044557)2.77819047
126hemidesmosome assembly (GO:0031581)2.77222743
127regulation of coagulation (GO:0050818)2.77190698
128negative regulation of viral entry into host cell (GO:0046597)2.76597471
129biotin metabolic process (GO:0006768)2.76569620
130cofactor biosynthetic process (GO:0051188)2.76239581
131growth hormone receptor signaling pathway (GO:0060396)2.75890248
132negative regulation of heart contraction (GO:0045822)2.74664996
133cellular response to dexamethasone stimulus (GO:0071549)2.73857211
134termination of G-protein coupled receptor signaling pathway (GO:0038032)2.73581088
135pathway-restricted SMAD protein phosphorylation (GO:0060389)2.72474929
136negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.72346076
137negative regulation of focal adhesion assembly (GO:0051895)2.69703663
138negative regulation of cell junction assembly (GO:1901889)2.69703663
139negative regulation of adherens junction organization (GO:1903392)2.69703663
140antibacterial humoral response (GO:0019731)2.68640668
141regulation of sarcomere organization (GO:0060297)2.68168958
142regulation of muscle hypertrophy (GO:0014743)2.67918694
143positive regulation of erythrocyte differentiation (GO:0045648)2.66906854
144regulation of MHC class II biosynthetic process (GO:0045346)2.66697049
145positive regulation of cAMP-mediated signaling (GO:0043950)2.66378213
146regulation of renal sodium excretion (GO:0035813)2.65592857
147negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.65550349
148termination of signal transduction (GO:0023021)2.65487790
149glomerular filtration (GO:0003094)2.61819983
150lysine metabolic process (GO:0006553)2.61706325
151lysine catabolic process (GO:0006554)2.61706325
152negative regulation of neural precursor cell proliferation (GO:2000178)2.59701455
153response to epinephrine (GO:0071871)2.59646583
154granulocyte activation (GO:0036230)2.58889770
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58832656
156regulation of fatty acid beta-oxidation (GO:0031998)2.58502463
157negative regulation of protein localization to plasma membrane (GO:1903077)2.58457525
158innate immune response in mucosa (GO:0002227)2.58385547
159response to dexamethasone (GO:0071548)2.58232091
160regulation of DNA endoreduplication (GO:0032875)2.58222418
161regulation of pigment cell differentiation (GO:0050932)2.57929110
162negative regulation of blood coagulation (GO:0030195)2.56971041
163negative regulation of hemostasis (GO:1900047)2.56971041
164lipid particle organization (GO:0034389)2.55832280
165phospholipid homeostasis (GO:0055091)2.55668031
166regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55595865
167megakaryocyte development (GO:0035855)2.55240205
168positive regulation of natural killer cell differentiation (GO:0032825)2.54819643
169G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.54683556
170peptide catabolic process (GO:0043171)2.54513183
171fatty acid beta-oxidation (GO:0006635)2.53630497
172cellular response to interferon-alpha (GO:0035457)2.53348728
173cGMP biosynthetic process (GO:0006182)2.52372250
174plasma lipoprotein particle clearance (GO:0034381)2.52287841
175regulation of cAMP-dependent protein kinase activity (GO:2000479)2.51906082
176renal filtration (GO:0097205)2.50977362
177positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49893376
178positive regulation of B cell mediated immunity (GO:0002714)2.49893376
179negative regulation of gluconeogenesis (GO:0045721)2.49761140
180female mating behavior (GO:0060180)2.49124041
181negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.49051066
182DNA damage response, signal transduction resulting in transcription (GO:0042772)2.48957496
183negative regulation of response to food (GO:0032096)2.48512973
184negative regulation of appetite (GO:0032099)2.48512973
185negative regulation of actin filament depolymerization (GO:0030835)2.47720046
186positive regulation of wound healing (GO:0090303)2.46594678
187regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.44748590
188cellular response to growth hormone stimulus (GO:0071378)2.44269507
189negative regulation of actin filament bundle assembly (GO:0032232)2.42319470
190antimicrobial humoral response (GO:0019730)2.40463123
191hemopoiesis (GO:0030097)2.40319065
192positive regulation of glucose import (GO:0046326)2.39200117
193protoporphyrinogen IX metabolic process (GO:0046501)15.3530000
194protoporphyrinogen IX biosynthetic process (GO:0006782)14.2531471
195porphyrin-containing compound biosynthetic process (GO:0006779)10.4163299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human7.00308844
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.39005622
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.37680912
4E2F7_22180533_ChIP-Seq_HELA_Human5.75276902
5GATA1_19941826_ChIP-Seq_K562_Human4.49420070
6* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.95955072
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.86368121
8KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.58318708
9* GATA1_19941827_ChIP-Seq_MEL_Mouse3.35592980
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35542068
11SCL_19346495_ChIP-Seq_HPC-7_Human3.18703639
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98176695
13GATA2_19941826_ChIP-Seq_K562_Human2.84703055
14EZH2_22144423_ChIP-Seq_EOC_Human2.72179361
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.71145979
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.54237652
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47151499
18GBX2_23144817_ChIP-Seq_PC3_Human2.44175053
19CLOCK_20551151_ChIP-Seq_293T_Human2.37525759
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.36277238
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33324342
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.30495232
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.25900224
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22028145
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11693061
26* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.98332030
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92980727
28GATA1_22383799_ChIP-Seq_G1ME_Mouse1.88726430
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.87548279
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.84639609
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84512318
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78286161
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76110831
34ZNF263_19887448_ChIP-Seq_K562_Human1.74229058
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71537129
36* SPI1_23127762_ChIP-Seq_K562_Human1.64840113
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.60560234
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57393603
39AR_21909140_ChIP-Seq_LNCAP_Human1.56603668
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55561577
41NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55561577
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55290330
43RUNX_20019798_ChIP-Seq_JUKART_Human1.54151189
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54137769
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52083440
46* RXR_22158963_ChIP-Seq_LIVER_Mouse1.51472521
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51001552
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49758202
49PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48097783
50TAF15_26573619_Chip-Seq_HEK293_Human1.47085780
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46361506
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.46129507
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.44407793
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42299464
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40398702
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.36189251
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34814964
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33524508
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33011918
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32775752
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31822626
62ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29693933
63SMAD4_21799915_ChIP-Seq_A2780_Human1.29356248
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25540154
65SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24291067
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23945122
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23811118
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22734083
69NCOR1_26117541_ChIP-Seq_K562_Human1.22644022
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21500048
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18771616
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.18693868
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18269589
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17606765
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.17349910
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.17349910
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15960340
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15247171
79BCAT_22108803_ChIP-Seq_LS180_Human1.14585792
80VDR_21846776_ChIP-Seq_THP-1_Human1.13654650
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12955831
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12737783
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12365927
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.11988754
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.10770649
86MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07658238
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.06513743
88CJUN_26792858_Chip-Seq_BT549_Human1.06264519
89IGF1R_20145208_ChIP-Seq_DFB_Human1.05896693
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.05730535
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05257304
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05079023
93TP53_16413492_ChIP-PET_HCT116_Human1.05029215
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04454750
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.04447808
96FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04425969
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04302071
98HTT_18923047_ChIP-ChIP_STHdh_Human1.04190593
99LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04034506
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.03097435
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01643069
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00962176
103STAT3_23295773_ChIP-Seq_U87_Human1.00850410
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00825694
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00005480
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99833881
107FOXO3_23340844_ChIP-Seq_DLD1_Human0.99722081
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99060740
109SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98365614
110VDR_22108803_ChIP-Seq_LS180_Human0.96991938
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.94492961
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94465113
113FOXM1_26456572_ChIP-Seq_MCF-7_Human0.93838173
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93609651
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93254426
116AR_21572438_ChIP-Seq_LNCaP_Human0.93106806
117AHR_22903824_ChIP-Seq_MCF-7_Human0.92668705
118GF1_26923725_Chip-Seq_HPCs_Mouse0.92138898
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.91901978
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91792827
121* TCF4_23295773_ChIP-Seq_U87_Human0.90873120
122VDR_24787735_ChIP-Seq_THP-1_Human0.89723473
123BP1_19119308_ChIP-ChIP_Hs578T_Human0.89199715
124RARG_19884340_ChIP-ChIP_MEFs_Mouse0.89006249
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88858107
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.88144329
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87488133
128AR_25329375_ChIP-Seq_VCAP_Human0.87139885
129FOXA2_19822575_ChIP-Seq_HepG2_Human0.86961049
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.86155893
131* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85935303
132HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85430738
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84657631
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83596502
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83482759
136TCF7_22412390_ChIP-Seq_EML_Mouse0.83130357
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82855535
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82393904
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82393904
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82304596
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80193280
142SALL1_21062744_ChIP-ChIP_HESCs_Human0.79398350
143MAF_26560356_Chip-Seq_TH1_Human0.79358504
144SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79207940
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79100374
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77815496
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77525035
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.77385759
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76963175
150SALL4_22934838_ChIP-ChIP_CD34+_Human0.76256943
151KDM2B_26808549_Chip-Seq_K562_Human0.75697449
152SPI1_20517297_ChIP-Seq_HL60_Human0.75605944
153GATA4_25053715_ChIP-Seq_YYC3_Human0.75508016
154PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73993396
155CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73018136
156KDM2B_26808549_Chip-Seq_DND41_Human0.72995213
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72976619
158ETS1_22383799_ChIP-Seq_G1ME_Mouse0.72710254
159TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.70861651
160ESR1_21235772_ChIP-Seq_MCF-7_Human0.69753886
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68766995
162ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67633681
163KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67499932
164EGR1_19374776_ChIP-ChIP_THP-1_Human0.66666615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level8.29580631
2MP0003656_abnormal_erythrocyte_physiolo7.56089448
3MP0008004_abnormal_stomach_pH6.26703431
4MP0005670_abnormal_white_adipose3.73761215
5MP0002837_dystrophic_cardiac_calcinosis3.32450448
6MP0000465_gastrointestinal_hemorrhage3.24075196
7MP0004510_myositis3.11689991
8MP0008438_abnormal_cutaneous_collagen3.04180198
9MP0004130_abnormal_muscle_cell3.01734305
10MP0005666_abnormal_adipose_tissue2.61489706
11MP0002254_reproductive_system_inflammat2.59347666
12MP0004185_abnormal_adipocyte_glucose2.33520563
13MP0003303_peritoneal_inflammation2.32304056
14MP0008775_abnormal_heart_ventricle2.31319971
15MP0005275_abnormal_skin_tensile2.30309523
16MP0005167_abnormal_blood-brain_barrier2.13569604
17MP0004215_abnormal_myocardial_fiber2.12071571
18MP0003705_abnormal_hypodermis_morpholog2.07260523
19MP0005397_hematopoietic_system_phenotyp2.05834395
20MP0001545_abnormal_hematopoietic_system2.05834395
21MP0000230_abnormal_systemic_arterial1.95778180
22MP0005375_adipose_tissue_phenotype1.90381503
23MP0003828_pulmonary_edema1.75709725
24MP0001851_eye_inflammation1.75500990
25MP0005083_abnormal_biliary_tract1.66384522
26MP0001835_abnormal_antigen_presentation1.64409473
27MP0000249_abnormal_blood_vessel1.64270693
28MP0010368_abnormal_lymphatic_system1.61553677
29MP0004084_abnormal_cardiac_muscle1.53684974
30MP0003638_abnormal_response/metabolism_1.44177288
31MP0001533_abnormal_skeleton_physiology1.43565624
32MP0003879_abnormal_hair_cell1.43541694
33MP0003191_abnormal_cellular_cholesterol1.42121918
34MP0004272_abnormal_basement_membrane1.40726820
35MP0002166_altered_tumor_susceptibility1.38597005
36MP0000003_abnormal_adipose_tissue1.37718608
37MP0006054_spinal_hemorrhage1.37297954
38MP0009115_abnormal_fat_cell1.31139732
39MP0000685_abnormal_immune_system1.30149022
40MP0003566_abnormal_cell_adhesion1.29519462
41MP0005334_abnormal_fat_pad1.27440460
42MP0010155_abnormal_intestine_physiology1.25884056
43MP0003091_abnormal_cell_migration1.25553191
44MP0009278_abnormal_bone_marrow1.21920921
45MP0010329_abnormal_lipoprotein_level1.21743932
46MP0005385_cardiovascular_system_phenoty1.21485267
47MP0001544_abnormal_cardiovascular_syste1.21485267
48MP0010386_abnormal_urinary_bladder1.21070701
49MP0001661_extended_life_span1.20249680
50MP0000681_abnormal_thyroid_gland1.18707696
51MP0003436_decreased_susceptibility_to1.18304325
52MP0002736_abnormal_nociception_after1.18050787
53MP0002972_abnormal_cardiac_muscle1.18040838
54MP0005330_cardiomyopathy1.15996797
55MP0002998_abnormal_bone_remodeling1.15267651
56MP0005000_abnormal_immune_tolerance1.14700400
57MP0002971_abnormal_brown_adipose1.13666877
58MP0000749_muscle_degeneration1.13501391
59MP0002060_abnormal_skin_morphology1.12327926
60MP0005409_darkened_coat_color1.11347773
61MP0003111_abnormal_nucleus_morphology1.10983742
62MP0004883_abnormal_blood_vessel1.08645943
63MP0002148_abnormal_hypersensitivity_rea1.07447201
64MP0002970_abnormal_white_adipose1.06762892
65MP0000013_abnormal_adipose_tissue1.05906728
66MP0005165_increased_susceptibility_to1.05616847
67MP0002009_preneoplasia1.04663727
68MP0002396_abnormal_hematopoietic_system1.04626219
69MP0010630_abnormal_cardiac_muscle1.04116095
70MP0000343_altered_response_to1.04096643
71MP0003950_abnormal_plasma_membrane1.03972421
72MP0003724_increased_susceptibility_to1.03437939
73MP0003045_fibrosis1.02064338
74MP0001790_abnormal_immune_system1.01043509
75MP0005387_immune_system_phenotype1.01043509
76MP0000609_abnormal_liver_physiology1.00884937
77MP0000751_myopathy1.00466073
78MP0002006_tumorigenesis0.99823737
79MP0006138_congestive_heart_failure0.98983206
80MP0004808_abnormal_hematopoietic_stem0.98975382
81MP0005595_abnormal_vascular_smooth0.98842693
82MP0004484_altered_response_of0.98368042
83MP0005636_abnormal_mineral_homeostasis0.97772130
84MP0010307_abnormal_tumor_latency0.97539911
85MP0005164_abnormal_response_to0.97528880
86MP0005620_abnormal_muscle_contractility0.97498986
87MP0004947_skin_inflammation0.97052948
88MP0008874_decreased_physiological_sensi0.96986883
89MP0002876_abnormal_thyroid_physiology0.95978950
90MP0005671_abnormal_response_to0.95969920
91MP0002295_abnormal_pulmonary_circulatio0.95772028
92MP0001800_abnormal_humoral_immune0.94536033
93MP0009764_decreased_sensitivity_to0.88927255
94MP0001958_emphysema0.87261134
95MP0001663_abnormal_digestive_system0.86145283
96MP0005410_abnormal_fertilization0.83625113
97MP0002723_abnormal_immune_serum0.83496862
98MP0005464_abnormal_platelet_physiology0.83431181
99MP0004087_abnormal_muscle_fiber0.82608654
100MP0002452_abnormal_antigen_presenting0.82069151
101MP0009931_abnormal_skin_appearance0.81350410
102MP0005501_abnormal_skin_physiology0.81038991
103MP0005503_abnormal_tendon_morphology0.80895762
104MP0005623_abnormal_meninges_morphology0.79627914
105MP0010094_abnormal_chromosome_stability0.79569722
106MP0005076_abnormal_cell_differentiation0.79155416
107MP0005023_abnormal_wound_healing0.78868291
108MP0002118_abnormal_lipid_homeostasis0.78402448
109MP0005084_abnormal_gallbladder_morpholo0.77944572
110MP0006036_abnormal_mitochondrial_physio0.76248364
111MP0000383_abnormal_hair_follicle0.74845926
112MP0003567_abnormal_fetal_cardiomyocyte0.74831033
113MP0009763_increased_sensitivity_to0.74461626
114MP0008995_early_reproductive_senescence0.72526491
115MP0003453_abnormal_keratinocyte_physiol0.71796722
116MP0002877_abnormal_melanocyte_morpholog0.71040733
117MP0001756_abnormal_urination0.70997255
118MP0003300_gastrointestinal_ulcer0.70524111
119MP0001664_abnormal_digestion0.70262768
120MP0002419_abnormal_innate_immunity0.70049105
121MP0003186_abnormal_redox_activity0.69340638
122MP0002139_abnormal_hepatobiliary_system0.69179878
123MP0000767_abnormal_smooth_muscle0.68268429
124MP0006276_abnormal_autonomic_nervous0.67687765
125MP0001879_abnormal_lymphatic_vessel0.67602926
126MP0001845_abnormal_inflammatory_respons0.67537768
127MP0000858_altered_metastatic_potential0.67362767
128MP0000266_abnormal_heart_morphology0.66831443
129MP0004036_abnormal_muscle_relaxation0.66528736
130MP0000689_abnormal_spleen_morphology0.65854473
131MP0009642_abnormal_blood_homeostasis0.65035853
132MP0002420_abnormal_adaptive_immunity0.64424049
133MP0000733_abnormal_muscle_development0.63583450
134MP0001727_abnormal_embryo_implantation0.63191186
135MP0002429_abnormal_blood_cell0.63159425
136MP0002127_abnormal_cardiovascular_syste0.62607716
137MP0001819_abnormal_immune_cell0.61930987
138MP0002332_abnormal_exercise_endurance0.61765804
139MP0003959_abnormal_lean_body0.60373652
140MP0009765_abnormal_xenobiotic_induced0.60289577
141MP0005390_skeleton_phenotype0.59818017
142MP0001614_abnormal_blood_vessel0.59752891
143MP0004085_abnormal_heartbeat0.59708752
144MP0002398_abnormal_bone_marrow0.59544807
145MP0002128_abnormal_blood_circulation0.59462911
146MP0000759_abnormal_skeletal_muscle0.59445694
147MP0001765_abnormal_ion_homeostasis0.59364950
148MP0002132_abnormal_respiratory_system0.58794460
149MP0002133_abnormal_respiratory_system0.57167084
150MP0005388_respiratory_system_phenotype0.57167084
151MP0009643_abnormal_urine_homeostasis0.56987441
152MP0010771_integument_phenotype0.56398083
153MP0010352_gastrointestinal_tract_polyps0.55800396
154MP0005319_abnormal_enzyme/_coenzyme0.55743373
155MP0005452_abnormal_adipose_tissue0.55721125
156MP0000598_abnormal_liver_morphology0.54168439

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)9.70591418
2Petechiae (HP:0000967)8.44707830
3Purpura (HP:0000979)7.97106270
4Hypochromic microcytic anemia (HP:0004840)7.51661456
5Acanthocytosis (HP:0001927)7.46011853
6Gingival bleeding (HP:0000225)6.82301643
7Reticulocytosis (HP:0001923)6.41164391
8Cholelithiasis (HP:0001081)5.91751038
9Impaired platelet aggregation (HP:0003540)5.44297261
10Abnormal platelet function (HP:0011869)5.44297261
11Spontaneous hematomas (HP:0007420)5.31848497
12Diaphragmatic weakness (HP:0009113)5.30157028
13Abnormal gallbladder morphology (HP:0012437)5.23337296
14Insomnia (HP:0100785)4.90732683
15Hyperlipoproteinemia (HP:0010980)4.73782109
16Abnormality of reticulocytes (HP:0004312)4.20560966
17Polycythemia (HP:0001901)4.05958483
18Hyperbilirubinemia (HP:0002904)3.99180871
19Thyroid-stimulating hormone excess (HP:0002925)3.93362020
20Paralysis (HP:0003470)3.93131706
21Right ventricular cardiomyopathy (HP:0011663)3.79974203
22Hypertriglyceridemia (HP:0002155)3.77763758
23Osteomalacia (HP:0002749)3.55508212
24Ileus (HP:0002595)3.48606287
25Microcytic anemia (HP:0001935)3.47073403
26Bruising susceptibility (HP:0000978)3.44572677
27Hypochromic anemia (HP:0001931)3.40108810
28Abnormality of the gallbladder (HP:0005264)3.39497534
29Abnormality of the common coagulation pathway (HP:0010990)3.38474848
30Conjunctival telangiectasia (HP:0000524)3.35638360
31Oligomenorrhea (HP:0000876)3.14843214
32Joint hemorrhage (HP:0005261)3.14671664
33Onycholysis (HP:0001806)3.03049073
34Acanthosis nigricans (HP:0000956)3.00246109
35Abnormality of the vasculature of the conjunctiva (HP:0008054)2.94219643
36Increased connective tissue (HP:0009025)2.90447011
37Abnormal pupillary function (HP:0007686)2.87718298
38Dyschromatopsia (HP:0007641)2.79610383
39Ventricular tachycardia (HP:0004756)2.78009298
40Cerebral aneurysm (HP:0004944)2.75077887
41Cutaneous photosensitivity (HP:0000992)2.71298709
42Nausea (HP:0002018)2.70659376
43Congenital sensorineural hearing impairment (HP:0008527)2.68871222
44Goiter (HP:0000853)2.65111189
45Prolonged bleeding time (HP:0003010)2.64865476
46Lipoatrophy (HP:0100578)2.62818527
47Abnormal gallbladder physiology (HP:0012438)2.62352233
48Cholecystitis (HP:0001082)2.62352233
49Increased density of long bones (HP:0006392)2.60169513
50Hepatocellular carcinoma (HP:0001402)2.56291729
51Aortic aneurysm (HP:0004942)2.42323643
52Thyroid carcinoma (HP:0002890)2.37589157
53Ventricular fibrillation (HP:0001663)2.31162005
54Hemorrhage of the eye (HP:0011885)2.29812562
55Broad metatarsal (HP:0001783)2.26204716
56Arterial thrombosis (HP:0004420)2.25681373
57Fragile skin (HP:0001030)2.24653129
58Hyperthyroidism (HP:0000836)2.23696195
59Increased serum ferritin (HP:0003281)2.23619353
60Joint swelling (HP:0001386)2.23490580
61Sudden death (HP:0001699)2.22742235
62Abnormality of complement system (HP:0005339)2.21538860
63Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.19849893
64Upper limb muscle weakness (HP:0003484)2.19371222
65Papillary thyroid carcinoma (HP:0002895)2.17821751
66Hypoalphalipoproteinemia (HP:0003233)2.16525605
67Spontaneous abortion (HP:0005268)2.11871941
68Recurrent gram-negative bacterial infections (HP:0005420)2.09392411
69Rectal prolapse (HP:0002035)2.07990644
70Hypoplasia of the iris (HP:0007676)2.07720894
71Insulin-resistant diabetes mellitus (HP:0000831)2.07395003
72Long foot (HP:0001833)2.05864830
73Atrial fibrillation (HP:0005110)2.05149849
74Abnormal auditory evoked potentials (HP:0006958)2.04385403
75Abnormality of iron homeostasis (HP:0011031)2.01720602
76Vertigo (HP:0002321)2.01654156
77Abnormality of the heme biosynthetic pathway (HP:0010472)11.1419639
78Poikilocytosis (HP:0004447)10.9139554
79Autoimmune hemolytic anemia (HP:0001890)1.98887199
80Increased mean platelet volume (HP:0011877)1.98568369
81Glomerulonephritis (HP:0000099)1.97907857
82Abnormality of macrophages (HP:0004311)1.97735157
83Xanthomatosis (HP:0000991)1.97623093
84Myocardial infarction (HP:0001658)1.96884416
85Complement deficiency (HP:0004431)1.96325447
86High pitched voice (HP:0001620)1.95059459
87Toxemia of pregnancy (HP:0100603)1.91987529
88Reduced subcutaneous adipose tissue (HP:0003758)1.89962510
89Supraventricular arrhythmia (HP:0005115)1.88559155
90Broad palm (HP:0001169)1.88004885
91Portal hypertension (HP:0001409)1.87468638
92Primary atrial arrhythmia (HP:0001692)1.87329771
93Abnormal platelet volume (HP:0011876)1.86888573
94Central scotoma (HP:0000603)1.86148566
95Abnormality of alanine metabolism (HP:0010916)1.85945529
96Hyperalaninemia (HP:0003348)1.85945529
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85945529
98Distal lower limb amyotrophy (HP:0008944)1.85856019
99Tinnitus (HP:0000360)1.85147238
100Mitral stenosis (HP:0001718)1.84749666
101Muscle fiber splitting (HP:0003555)1.83624585
102Nephritis (HP:0000123)1.82041311
103Abnormal number of erythroid precursors (HP:0012131)1.82025493
104Supraventricular tachycardia (HP:0004755)1.81608178
105Ankle contracture (HP:0006466)1.81517259
106Systemic lupus erythematosus (HP:0002725)1.81396266
107Abnormality of transition element cation homeostasis (HP:0011030)1.81356490
108Aneurysm (HP:0002617)1.78441896
109Hyponatremia (HP:0002902)1.77302873
110Bundle branch block (HP:0011710)1.76600096
111Osteolytic defects of the hand bones (HP:0009699)1.75050314
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.75050314
113Scapular winging (HP:0003691)1.72316433
114Pustule (HP:0200039)1.72080559
115Chest pain (HP:0100749)1.71644636
116Cortical dysplasia (HP:0002539)1.71569821
117Hypoglycemic coma (HP:0001325)1.71474878
118Prenatal maternal abnormality (HP:0002686)1.69203090
119Large hands (HP:0001176)1.68817268
120Hyporeflexia of lower limbs (HP:0002600)1.68789547
121Dilated cardiomyopathy (HP:0001644)1.67163261
122Duplicated collecting system (HP:0000081)1.66682054
123Short middle phalanx of the 5th finger (HP:0004220)1.66259447
124Myoglobinuria (HP:0002913)1.65628402
125Decreased central vision (HP:0007663)1.65139281
126Abnormality of the hepatic vasculature (HP:0006707)1.64988404
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.64913951
128Urticaria (HP:0001025)1.64614309
129Aortic dissection (HP:0002647)1.64483809
130Abnormality of sodium homeostasis (HP:0010931)1.62977760
131Abnormality of cells of the erythroid lineage (HP:0012130)1.62042723
132Striae distensae (HP:0001065)1.61547721
133Testicular neoplasm (HP:0010788)1.61126388
134Palpitations (HP:0001962)1.60238421
135Multiple enchondromatosis (HP:0005701)1.60208581
136Growth hormone excess (HP:0000845)1.60042559
137Hematochezia (HP:0002573)1.59156503
138Abnormality of the nasal mucosa (HP:0000433)1.59093640
139Renal tubular acidosis (HP:0001947)1.58873014
140Abnormality of lateral ventricle (HP:0030047)1.58556178
141Mitral valve prolapse (HP:0001634)1.58404457
142Childhood onset (HP:0011463)1.58277236
143Elfin facies (HP:0004428)1.58271395
144Biliary tract neoplasm (HP:0100574)1.58209019
145Difficulty running (HP:0009046)1.58190571
146Hyperacusis (HP:0010780)1.56030950
147Abnormality of the fingertips (HP:0001211)1.55782041
148Nasolacrimal duct obstruction (HP:0000579)1.55093930
149Cerebral palsy (HP:0100021)1.54922382
150Esophageal varix (HP:0002040)1.54004036
151Enlarged penis (HP:0000040)1.52308251
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.51271941
153Dilatation of the ascending aorta (HP:0005111)1.51150209
154Thrombophlebitis (HP:0004418)1.50311144
155Syncope (HP:0001279)1.50265561
156Epistaxis (HP:0000421)1.49686486
157Thrombocytosis (HP:0001894)1.46432532
158Gastrointestinal dysmotility (HP:0002579)1.45694351
159Male infertility (HP:0003251)1.45035506
160Eczematoid dermatitis (HP:0000976)1.43612903
161Increased IgM level (HP:0003496)1.41303587
162Arthropathy (HP:0003040)1.40896710
163Cerebral ischemia (HP:0002637)1.40860685
164Basal ganglia calcification (HP:0002135)1.36176739
165Abnormal ciliary motility (HP:0012262)1.35923122
166Distal lower limb muscle weakness (HP:0009053)1.35783161
167Lower limb amyotrophy (HP:0007210)1.34997269
168Arthralgia (HP:0002829)1.34491803
169Bilateral sensorineural hearing impairment (HP:0008619)1.33290033
170Episodic fever (HP:0001954)1.30688368
171Difficulty walking (HP:0002355)1.30454151
172Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.30209352
173Hepatosplenomegaly (HP:0001433)1.29059404
174Cerebral hemorrhage (HP:0001342)1.28770941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.51681381
2RIPK44.26022572
3MST43.85303410
4TRIB33.29882849
5TEC3.20250126
6ZAK3.14374395
7EIF2AK12.98344069
8STK42.93368231
9BMX2.91991610
10CAMK1G2.89926001
11TLK12.80700362
12PKN22.53721926
13PIK3CG2.52554754
14TTN2.51275342
15EEF2K2.50592639
16CDK122.42418506
17LMTK22.39738221
18BTK2.38427390
19TAOK32.35402391
20SIK12.20422344
21TIE12.18192228
22TGFBR22.03189408
23EPHA31.96564660
24BMPR21.92136416
25CSF1R1.73278809
26CDK91.70494162
27STK101.62394946
28TRPM71.61309611
29ZAP701.60667775
30GRK51.57571237
31STK241.53860790
32RIPK11.49771773
33PDK41.43131723
34PDK31.43131723
35RPS6KB21.41192842
36VRK11.40975118
37FES1.40554088
38HCK1.40049712
39BLK1.32859763
40MAP3K101.32772488
41PRKAA21.31919553
42FER1.30237452
43BCKDK1.30213073
44CDK61.28327456
45NLK1.26192663
46ITK1.24588693
47CDC71.23066130
48ACVR1B1.22315713
49IRAK11.17839246
50RPS6KA51.17798349
51INSRR1.14141911
52JAK21.13429061
53LATS11.13113445
54CSK1.12643733
55PRKAA11.11941656
56MAPK111.09372283
57STK31.08668295
58FGR1.08475857
59FLT31.08118757
60DAPK31.06309605
61PIK3CA1.06185292
62NEK91.02125496
63CDK41.00058507
64SGK20.99192786
65MAP2K30.98956132
66LRRK20.96726405
67MAP3K50.95524938
68EIF2AK20.91398034
69MAP3K80.91155504
70MAPK120.90211398
71FGFR30.88718058
72JAK10.87174243
73MAPKAPK30.86953597
74PDPK10.86599347
75AKT30.86145178
76ERBB20.85095369
77LYN0.84591532
78PIM10.82738439
79DDR20.82017772
80AURKB0.80666020
81PDGFRA0.80591991
82ADRBK10.80119903
83ADRBK20.79785110
84MYLK0.79573570
85GRK60.78676210
86PTK2B0.78340929
87EPHB10.78018471
88MST1R0.77958475
89PNCK0.77629087
90RET0.76383340
91IKBKB0.76343758
92JAK30.76320611
93SCYL20.75957293
94FGFR20.75371708
95TTK0.74917313
96MAP2K10.74666787
97NEK20.72662327
98TYK20.72315129
99CDC42BPA0.72241785
100MELK0.71998248
101PAK10.71720134
102MAP3K60.71537320
103FGFR40.70925375
104EPHB20.70467696
105MTOR0.70105615
106SGK30.66623213
107PAK20.65623038
108BRD40.65225359
109WNK10.64995080
110DMPK0.64361860
111KDR0.63859738
112BRSK10.63443294
113TNK20.61537835
114MAPKAPK50.60121189
115BMPR1B0.57751363
116OBSCN0.56216501
117DYRK30.55106036
118FRK0.54199752
119MAP3K30.53610485
120MARK30.51536730
121ROCK10.49972333
122LCK0.49309194
123PRKACG0.49003222
124PHKG10.48145608
125PHKG20.48145608
126KIT0.45379383
127PRKG10.45327800
128TNIK0.45043872
129STK38L0.44344673
130PLK20.43594895
131NME20.43512212
132CAMK10.41749575
133IKBKE0.41404904
134PKN10.40325759
135TXK0.40072344
136CHEK20.40013967
137PRKCH0.39891874
138DAPK20.39837364
139MAP3K70.39287057
140ATM0.39266093
141ERN10.38445842
142PDGFRB0.38106923
143SGK2230.37662961
144SGK4940.37662961
145PIM20.37437658
146CAMKK20.36869772
147MET0.35838872
148GRK70.35830547
149NUAK10.35725635
150FYN0.35171991
151IGF1R0.34248526
152PTK60.34180506
153PRKD10.33573977
154PDK10.33141519
155TGFBR10.32061360
156SGK10.31167562
157SYK0.31167545
158MAPK70.30912510
159MAPKAPK20.30395208
160ILK0.30251408
161PDK20.30179955
162HIPK20.29956796

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.80330720
2Systemic lupus erythematosus_Homo sapiens_hsa053225.63961566
3Vitamin B6 metabolism_Homo sapiens_hsa007504.12262328
4Fatty acid biosynthesis_Homo sapiens_hsa000612.97971959
5Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.89539348
6Propanoate metabolism_Homo sapiens_hsa006402.67321151
7Alcoholism_Homo sapiens_hsa050342.55807276
8PPAR signaling pathway_Homo sapiens_hsa033202.37360035
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20302398
10Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.07639088
11ABC transporters_Homo sapiens_hsa020102.05044503
12Fatty acid degradation_Homo sapiens_hsa000712.01297257
13Vascular smooth muscle contraction_Homo sapiens_hsa042702.00347648
14Fatty acid metabolism_Homo sapiens_hsa012121.91589586
15ECM-receptor interaction_Homo sapiens_hsa045121.88784022
16Caffeine metabolism_Homo sapiens_hsa002321.80858644
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76352629
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73665862
19Pyruvate metabolism_Homo sapiens_hsa006201.65959803
20Adipocytokine signaling pathway_Homo sapiens_hsa049201.65448591
21Small cell lung cancer_Homo sapiens_hsa052221.64921601
22AMPK signaling pathway_Homo sapiens_hsa041521.60980807
23Hematopoietic cell lineage_Homo sapiens_hsa046401.54644760
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.54158820
25Arachidonic acid metabolism_Homo sapiens_hsa005901.53000895
26Malaria_Homo sapiens_hsa051441.50939962
27Gap junction_Homo sapiens_hsa045401.50272172
28Viral carcinogenesis_Homo sapiens_hsa052031.43175852
29Chemokine signaling pathway_Homo sapiens_hsa040621.36126678
30B cell receptor signaling pathway_Homo sapiens_hsa046621.35120640
31Autoimmune thyroid disease_Homo sapiens_hsa053201.34273078
32Serotonergic synapse_Homo sapiens_hsa047261.33138977
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30449023
34Glycerolipid metabolism_Homo sapiens_hsa005611.27805959
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.24447170
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24117130
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.22426283
38Insulin resistance_Homo sapiens_hsa049311.20503168
39beta-Alanine metabolism_Homo sapiens_hsa004101.17163222
40Focal adhesion_Homo sapiens_hsa045101.01455591
41Pancreatic secretion_Homo sapiens_hsa049721.00849378
42Lysine degradation_Homo sapiens_hsa003100.99553337
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99170893
44Complement and coagulation cascades_Homo sapiens_hsa046100.96936773
45Insulin signaling pathway_Homo sapiens_hsa049100.96671570
46Thyroid hormone synthesis_Homo sapiens_hsa049180.96103280
47Rap1 signaling pathway_Homo sapiens_hsa040150.93270897
48Fat digestion and absorption_Homo sapiens_hsa049750.92856411
49Choline metabolism in cancer_Homo sapiens_hsa052310.92769032
50Cell cycle_Homo sapiens_hsa041100.92598709
51Carbon metabolism_Homo sapiens_hsa012000.92484241
52Dilated cardiomyopathy_Homo sapiens_hsa054140.92312864
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.90554290
54Nitrogen metabolism_Homo sapiens_hsa009100.90324843
55Long-term depression_Homo sapiens_hsa047300.87498383
56Phagosome_Homo sapiens_hsa041450.85446329
57Dorso-ventral axis formation_Homo sapiens_hsa043200.85351851
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84292060
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82729610
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82013597
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81981083
62Endocytosis_Homo sapiens_hsa041440.81875989
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80619660
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80448513
65T cell receptor signaling pathway_Homo sapiens_hsa046600.79076977
66Chronic myeloid leukemia_Homo sapiens_hsa052200.79017085
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78143155
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77897136
69Protein digestion and absorption_Homo sapiens_hsa049740.77204934
70Tryptophan metabolism_Homo sapiens_hsa003800.75778061
71Platelet activation_Homo sapiens_hsa046110.74728140
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73655289
73Toxoplasmosis_Homo sapiens_hsa051450.73023278
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72994286
75Endometrial cancer_Homo sapiens_hsa052130.71928092
76Staphylococcus aureus infection_Homo sapiens_hsa051500.71839355
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71642347
78Gastric acid secretion_Homo sapiens_hsa049710.71632855
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71283972
80Linoleic acid metabolism_Homo sapiens_hsa005910.70213634
81Ovarian steroidogenesis_Homo sapiens_hsa049130.69809072
82Viral myocarditis_Homo sapiens_hsa054160.68364246
83Circadian entrainment_Homo sapiens_hsa047130.67852480
84Calcium signaling pathway_Homo sapiens_hsa040200.67639852
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67546062
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67544009
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66857048
88Shigellosis_Homo sapiens_hsa051310.66351728
89Ras signaling pathway_Homo sapiens_hsa040140.65694255
90Renal cell carcinoma_Homo sapiens_hsa052110.65247147
91Glucagon signaling pathway_Homo sapiens_hsa049220.63935235
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62661548
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.62466652
94Herpes simplex infection_Homo sapiens_hsa051680.60439005
95Oxytocin signaling pathway_Homo sapiens_hsa049210.60105155
96Graft-versus-host disease_Homo sapiens_hsa053320.59303853
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59188518
98Proteoglycans in cancer_Homo sapiens_hsa052050.58550392
99Olfactory transduction_Homo sapiens_hsa047400.58538454
100Amoebiasis_Homo sapiens_hsa051460.58031176
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57194744
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.57082629
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56226846
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55994226
105VEGF signaling pathway_Homo sapiens_hsa043700.55669298
106Non-small cell lung cancer_Homo sapiens_hsa052230.55486179
107Glioma_Homo sapiens_hsa052140.54859049
108Asthma_Homo sapiens_hsa053100.54858468
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54825890
110Type II diabetes mellitus_Homo sapiens_hsa049300.53093174
111Morphine addiction_Homo sapiens_hsa050320.52651503
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52455631
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.51011273
114Pancreatic cancer_Homo sapiens_hsa052120.50749523
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.50353087
116Selenocompound metabolism_Homo sapiens_hsa004500.49856394
117TNF signaling pathway_Homo sapiens_hsa046680.48726468
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48280838
119Apoptosis_Homo sapiens_hsa042100.48053862
120Phenylalanine metabolism_Homo sapiens_hsa003600.47640690
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47225718
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.46883216
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46224040
124Measles_Homo sapiens_hsa051620.46030598
125Renin-angiotensin system_Homo sapiens_hsa046140.44509225
126Allograft rejection_Homo sapiens_hsa053300.44106692
127p53 signaling pathway_Homo sapiens_hsa041150.44077049
128Pertussis_Homo sapiens_hsa051330.43654946
129MAPK signaling pathway_Homo sapiens_hsa040100.43009001
130Antigen processing and presentation_Homo sapiens_hsa046120.42015169
131Hepatitis B_Homo sapiens_hsa051610.41502523
132DNA replication_Homo sapiens_hsa030300.40227517
133FoxO signaling pathway_Homo sapiens_hsa040680.39908709
134HTLV-I infection_Homo sapiens_hsa051660.37807496
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36888977
136MicroRNAs in cancer_Homo sapiens_hsa052060.35490665
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35418323
138Tyrosine metabolism_Homo sapiens_hsa003500.34815805
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.34520228
140HIF-1 signaling pathway_Homo sapiens_hsa040660.33022492
141Pentose phosphate pathway_Homo sapiens_hsa000300.32185562
142Influenza A_Homo sapiens_hsa051640.32139614
143Renin secretion_Homo sapiens_hsa049240.31546900
144Bladder cancer_Homo sapiens_hsa052190.31359808
145Sulfur relay system_Homo sapiens_hsa041220.29250771
146mTOR signaling pathway_Homo sapiens_hsa041500.28797382
147Arginine biosynthesis_Homo sapiens_hsa002200.28495354
148Hepatitis C_Homo sapiens_hsa051600.26698231
149Osteoclast differentiation_Homo sapiens_hsa043800.26139309
150Glutathione metabolism_Homo sapiens_hsa004800.24535462
151Acute myeloid leukemia_Homo sapiens_hsa052210.23198079
152Peroxisome_Homo sapiens_hsa041460.22816365
153Melanoma_Homo sapiens_hsa052180.21253063
154Notch signaling pathway_Homo sapiens_hsa043300.21102988
155Adherens junction_Homo sapiens_hsa045200.20806498
156Central carbon metabolism in cancer_Homo sapiens_hsa052300.19835034
157Leishmaniasis_Homo sapiens_hsa051400.19804401
158Pathways in cancer_Homo sapiens_hsa052000.19620632
159Prostate cancer_Homo sapiens_hsa052150.19427961
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18067694

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