PKIB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)5.01366547
2regulation of dendritic cell antigen processing and presentation (GO:0002604)3.87408624
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.84838552
4ATP synthesis coupled proton transport (GO:0015986)3.76500611
5energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76500611
6positive regulation of antigen processing and presentation (GO:0002579)3.75071137
7growth hormone receptor signaling pathway (GO:0060396)3.73187174
8mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72830657
9G-protein coupled receptor internalization (GO:0002031)3.65831856
10water-soluble vitamin biosynthetic process (GO:0042364)3.44629347
11regulation of T-helper 1 cell differentiation (GO:0045625)3.42620142
12protein neddylation (GO:0045116)3.41546704
13regulation of antigen processing and presentation (GO:0002577)3.33639646
14dendritic cell chemotaxis (GO:0002407)3.30559292
15regulation of activation of Janus kinase activity (GO:0010533)3.28795985
16behavioral response to nicotine (GO:0035095)3.21648861
17cellular response to growth hormone stimulus (GO:0071378)3.21541411
18electron transport chain (GO:0022900)3.21247124
19respiratory electron transport chain (GO:0022904)3.19672644
20response to peptidoglycan (GO:0032494)3.08375639
21respiratory chain complex IV assembly (GO:0008535)3.07645674
22positive regulation of cellular amide metabolic process (GO:0034250)3.04918260
23dendritic cell migration (GO:0036336)3.04670735
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03894166
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03894166
26neutrophil activation (GO:0042119)3.01833775
27superoxide metabolic process (GO:0006801)3.00746057
28regulation of interleukin-1 beta secretion (GO:0050706)2.99493922
29chaperone-mediated protein transport (GO:0072321)2.98372867
30sympathetic nervous system development (GO:0048485)2.96925087
31L-fucose catabolic process (GO:0042355)2.95718430
32fucose catabolic process (GO:0019317)2.95718430
33L-fucose metabolic process (GO:0042354)2.95718430
34positive regulation of interleukin-1 beta secretion (GO:0050718)2.90896142
35positive regulation of interleukin-12 production (GO:0032735)2.90175821
36establishment of protein localization to mitochondrial membrane (GO:0090151)2.86201250
37granulocyte activation (GO:0036230)2.85235577
38detection of bacterium (GO:0016045)2.84127982
39detection of other organism (GO:0098543)2.83548506
40regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.83295830
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80333393
42response to host immune response (GO:0052572)2.80333393
43modulation by symbiont of host immune response (GO:0052553)2.79542482
44positive regulation by symbiont of host defense response (GO:0052509)2.79542482
45modulation by symbiont of host defense response (GO:0052031)2.79542482
46modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79542482
47modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79542482
48positive regulation by organism of defense response of other organism involved in symbiotic interact2.79542482
49neutrophil activation involved in immune response (GO:0002283)2.77800654
50protein complex biogenesis (GO:0070271)2.76632091
51opioid receptor signaling pathway (GO:0038003)2.75362480
52aldehyde catabolic process (GO:0046185)2.74435867
53positive regulation of type 2 immune response (GO:0002830)2.73649706
54mitochondrial respiratory chain complex assembly (GO:0033108)2.71940522
55G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71655276
56mitochondrial respiratory chain complex I assembly (GO:0032981)2.71490529
57NADH dehydrogenase complex assembly (GO:0010257)2.71490529
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71490529
59cullin deneddylation (GO:0010388)2.70594009
60DNA damage response, detection of DNA damage (GO:0042769)2.70025554
61regulation of cilium movement (GO:0003352)2.67961983
62energy homeostasis (GO:0097009)2.67703698
63positive regulation of interleukin-1 secretion (GO:0050716)2.66332271
64nonmotile primary cilium assembly (GO:0035058)2.65507418
65centriole assembly (GO:0098534)2.65203085
66monocyte chemotaxis (GO:0002548)2.64029974
67myeloid dendritic cell activation (GO:0001773)2.63988328
68positive regulation of interleukin-17 production (GO:0032740)2.62852037
69epithelial cilium movement (GO:0003351)2.62476049
70neuronal action potential propagation (GO:0019227)2.61714277
71regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58363076
72kidney morphogenesis (GO:0060993)2.57871602
73proteasome assembly (GO:0043248)2.55544672
74maturation of SSU-rRNA (GO:0030490)2.55505375
75sphingoid metabolic process (GO:0046519)2.55210608
76negative regulation of keratinocyte proliferation (GO:0010839)2.55168904
77negative regulation of homotypic cell-cell adhesion (GO:0034111)2.54928804
78regulation of platelet aggregation (GO:0090330)2.54212898
79positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52691749
80positive regulation of interleukin-10 production (GO:0032733)2.51916137
81regulation of timing of cell differentiation (GO:0048505)2.51411209
82regulation of memory T cell differentiation (GO:0043380)2.50340748
83ATP biosynthetic process (GO:0006754)2.49678875
84regulation of non-canonical Wnt signaling pathway (GO:2000050)2.48726354
85negative regulation of DNA-dependent DNA replication (GO:2000104)2.47610368
86protein-cofactor linkage (GO:0018065)2.47134386
87ubiquinone metabolic process (GO:0006743)2.46521614
88regulation of interleukin-1 secretion (GO:0050704)2.46417411
89cytochrome complex assembly (GO:0017004)2.45397946
90purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45101274
91positive regulation of respiratory burst (GO:0060267)2.45073906
92transcription elongation from RNA polymerase III promoter (GO:0006385)2.44756182
93termination of RNA polymerase III transcription (GO:0006386)2.44756182
94purinergic nucleotide receptor signaling pathway (GO:0035590)2.43897116
95CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.42685040
96T-helper cell differentiation (GO:0042093)2.42685040
97ceramide catabolic process (GO:0046514)2.42488926
98purine nucleoside triphosphate biosynthetic process (GO:0009145)2.42417956
99positive regulation of T-helper cell differentiation (GO:0045624)2.42405059
100regulation of hypersensitivity (GO:0002883)2.42354004
101positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.42250846
102hydrogen ion transmembrane transport (GO:1902600)2.42050940
103positive regulation of interleukin-1 beta production (GO:0032731)2.41413083
104DNA integration (GO:0015074)2.40914669
105protein deneddylation (GO:0000338)2.40701243
106cellular response to zinc ion (GO:0071294)2.39861889
107negative regulation of granulocyte differentiation (GO:0030853)2.38816876
108presynaptic membrane assembly (GO:0097105)2.37663683
109C4-dicarboxylate transport (GO:0015740)2.37018944
110myeloid dendritic cell differentiation (GO:0043011)2.36835355
111cilium movement (GO:0003341)2.35533651
112eosinophil chemotaxis (GO:0048245)2.35417064
113cellular ketone body metabolic process (GO:0046950)2.34067776
114keratinocyte development (GO:0003334)2.34022211
115microglial cell activation (GO:0001774)2.33482194
116transmission of nerve impulse (GO:0019226)2.33130447
117peptidyl-histidine modification (GO:0018202)2.32989537
118regulation of T-helper 2 cell differentiation (GO:0045628)2.32543735
119protein polyglutamylation (GO:0018095)2.31978673
120lipoxygenase pathway (GO:0019372)2.31633944
121positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.31633496
122cellular response to exogenous dsRNA (GO:0071360)2.31471465
123GTP biosynthetic process (GO:0006183)2.30605537
124intraciliary transport (GO:0042073)2.29987583
125sphingosine metabolic process (GO:0006670)2.28439873
126acrosome reaction (GO:0007340)2.28332362
127proton transport (GO:0015992)2.28218823
128positive regulation of cAMP-mediated signaling (GO:0043950)2.27155233
129axonemal dynein complex assembly (GO:0070286)2.26601016
130positive regulation of T-helper 1 type immune response (GO:0002827)2.26469609
131intestinal epithelial cell development (GO:0060576)2.26353444
132amino sugar catabolic process (GO:0046348)2.26262031
133nucleoside diphosphate catabolic process (GO:0009134)2.25719461
134ribosomal small subunit assembly (GO:0000028)2.25544606
135positive regulation of interleukin-1 production (GO:0032732)2.25082298
136interferon-gamma production (GO:0032609)2.25061195
137negative regulation of T cell mediated immunity (GO:0002710)2.24795600
138cholesterol biosynthetic process (GO:0006695)2.24468024
139regulation of centriole replication (GO:0046599)2.23711605
140somite rostral/caudal axis specification (GO:0032525)2.23684384
141diol metabolic process (GO:0034311)2.23346653
142response to muramyl dipeptide (GO:0032495)2.23337122
143ubiquinone biosynthetic process (GO:0006744)2.23045962
144auditory behavior (GO:0031223)2.23021458
145type I interferon signaling pathway (GO:0060337)2.22848499
146cellular response to type I interferon (GO:0071357)2.22848499
147presynaptic membrane organization (GO:0097090)2.22210729
148chromatin remodeling at centromere (GO:0031055)2.22028690
149negative regulation of viral genome replication (GO:0045071)2.22003182
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.21987459
151response to host (GO:0075136)2.21987459
152response to host defenses (GO:0052200)2.21987459
153positive regulation of heat generation (GO:0031652)2.21755434
154regulation of interleukin-17 production (GO:0032660)2.21700531
155calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.21618134
156lymphoid progenitor cell differentiation (GO:0002320)2.21506276
157hydrogen transport (GO:0006818)2.21501329
158regulation of mitotic spindle checkpoint (GO:1903504)2.21268324
159regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.21268324
160ribonucleoside triphosphate biosynthetic process (GO:0009201)2.20895829
161mesenchymal cell differentiation involved in kidney development (GO:0072161)2.20760326
162mesenchymal cell differentiation involved in renal system development (GO:2001012)2.20760326
163oxidative phosphorylation (GO:0006119)2.20381261
164ganglion development (GO:0061548)2.20140907
165response to type I interferon (GO:0034340)2.20116702
166cilium morphogenesis (GO:0060271)2.19461882
167positive regulation of prostaglandin secretion (GO:0032308)2.19397977
168detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.19259964
169axoneme assembly (GO:0035082)2.19161041
170positive regulation of alpha-beta T cell proliferation (GO:0046641)2.19001412
171cellular response to interleukin-15 (GO:0071350)2.18261959
172vocalization behavior (GO:0071625)2.17975304
173negative regulation of transcription regulatory region DNA binding (GO:2000678)2.17424836
174regulation of T-helper 1 type immune response (GO:0002825)2.17280449
175androgen biosynthetic process (GO:0006702)2.17022948
176preassembly of GPI anchor in ER membrane (GO:0016254)2.15752174
177nucleoside triphosphate biosynthetic process (GO:0009142)2.15523627
178sterol biosynthetic process (GO:0016126)2.15051962
179cochlea development (GO:0090102)2.13932122
180dendritic spine morphogenesis (GO:0060997)2.12317069
181epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.10775561
182short-term memory (GO:0007614)2.10449787
183mechanosensory behavior (GO:0007638)2.09143399
184protein localization to cilium (GO:0061512)2.09115721
185regulation of guanylate cyclase activity (GO:0031282)2.08215908
186quinone biosynthetic process (GO:1901663)2.07439016
187intracellular protein transmembrane import (GO:0044743)2.07301091
188negative regulation of heart rate (GO:0010459)2.06510866
189neurofilament cytoskeleton organization (GO:0060052)2.06220333
190GPI anchor metabolic process (GO:0006505)2.05804363
191tRNA processing (GO:0008033)2.03716484
192innervation (GO:0060384)2.02594348
193G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.02276215
194estrogen biosynthetic process (GO:0006703)2.02000573
195establishment of protein localization to mitochondrion (GO:0072655)2.01417976
196L-serine metabolic process (GO:0006563)2.01386175
197CENP-A containing nucleosome assembly (GO:0034080)2.00803139
198protein targeting to mitochondrion (GO:0006626)2.00252846
199ketone body metabolic process (GO:1902224)2.00092872
200isoprenoid biosynthetic process (GO:0008299)2.00014201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.19024978
2GBX2_23144817_ChIP-Seq_PC3_Human3.09871874
3EZH2_22144423_ChIP-Seq_EOC_Human2.97359074
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.93323349
5PCGF2_27294783_Chip-Seq_ESCs_Mouse2.83054893
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74297640
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.63585031
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.57593842
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56894536
10* GABP_17652178_ChIP-ChIP_JURKAT_Human2.53565160
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.48844565
12* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.44179007
13ZNF274_21170338_ChIP-Seq_K562_Hela2.42471262
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41641955
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.33943235
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.33387440
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29558280
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21446203
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.18936670
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.17264077
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.10595842
22* EZH2_27294783_Chip-Seq_NPCs_Mouse2.06605940
23FUS_26573619_Chip-Seq_HEK293_Human2.02559185
24EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.01599894
25P53_22387025_ChIP-Seq_ESCs_Mouse2.01256674
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.98531246
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.97625841
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.95180953
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.95022764
30NMYC_18555785_Chip-Seq_ESCs_Mouse1.94054287
31SUZ12_18555785_Chip-Seq_ESCs_Mouse1.93448923
32STAT3_18555785_Chip-Seq_ESCs_Mouse1.91740120
33E2F1_18555785_Chip-Seq_ESCs_Mouse1.90747177
34EWS_26573619_Chip-Seq_HEK293_Human1.87339578
35EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.86236232
36IGF1R_20145208_ChIP-Seq_DFB_Human1.86054026
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.85860871
38CMYC_18555785_Chip-Seq_ESCs_Mouse1.85108266
39P300_18555785_Chip-Seq_ESCs_Mouse1.76328425
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73879803
41OCT4_18555785_Chip-Seq_ESCs_Mouse1.72834436
42RUNX1_27457419_Chip-Seq_LIVER_Mouse1.72804741
43* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72774748
44SOX2_18555785_Chip-Seq_ESCs_Mouse1.72451242
45PU1_27457419_Chip-Seq_LIVER_Mouse1.70988871
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.70212600
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68874169
48* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.67436278
49P300_19829295_ChIP-Seq_ESCs_Human1.65713462
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64315299
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64225159
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.63607959
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.62582397
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61259076
55ESRRB_18555785_Chip-Seq_ESCs_Mouse1.60712447
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60407176
57RNF2_27304074_Chip-Seq_NSC_Mouse1.60268757
58KLF4_18555785_Chip-Seq_ESCs_Mouse1.59662588
59TAF15_26573619_Chip-Seq_HEK293_Human1.59624572
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58853481
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.58405583
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56476564
63* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56294446
64* MYC_18940864_ChIP-ChIP_HL60_Human1.56131736
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.55917563
66SMAD1_18555785_Chip-Seq_ESCs_Mouse1.55602258
67CTCF_18555785_Chip-Seq_ESCs_Mouse1.55434379
68* ELK1_19687146_ChIP-ChIP_HELA_Human1.55090103
69* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54291731
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51014258
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.48868023
72* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.47978011
73* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.47309611
74* CRX_20693478_ChIP-Seq_RETINA_Mouse1.47145716
75IRF1_19129219_ChIP-ChIP_H3396_Human1.46689105
76* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45761607
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.45571310
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44917970
79HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43864645
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42134486
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39763924
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.37820703
83MYC_18555785_ChIP-Seq_MESCs_Mouse1.37430548
84VDR_22108803_ChIP-Seq_LS180_Human1.37247503
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.37230343
86* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.37142885
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36834731
88TP53_18474530_ChIP-ChIP_U2OS_Human1.36235876
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35596121
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34398257
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34168485
92TP53_22573176_ChIP-Seq_HFKS_Human1.32797923
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.31623183
94KDM2B_26808549_Chip-Seq_REH_Human1.30607146
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30282947
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29591766
97* SMAD4_21799915_ChIP-Seq_A2780_Human1.27856440
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27841162
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26692747
100* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25565395
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25107771
102* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24978546
103REST_21632747_ChIP-Seq_MESCs_Mouse1.24829516
104ER_23166858_ChIP-Seq_MCF-7_Human1.24638222
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.24097233
106SOX2_16153702_ChIP-ChIP_HESCs_Human1.22249534
107PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20438987
108VDR_23849224_ChIP-Seq_CD4+_Human1.19968412
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19559446
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19470283
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18242329
112* EZH2_27294783_Chip-Seq_ESCs_Mouse1.18230677
113EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15670646
114RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15670646
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15173799
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14742413
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14520854
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14458454
119ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.14334334
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11867312
121CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11828019
122* TTF2_22483619_ChIP-Seq_HELA_Human1.10948545
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10259505
124AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10252329
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09170185
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.09025989
127* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08648231
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08487378
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08006202
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07542718
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07340804
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07340804
133IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07103625
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06867322
135RUNX2_22187159_ChIP-Seq_PCA_Human1.06725662
136AR_25329375_ChIP-Seq_VCAP_Human1.06628106
137LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06532211
138TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06188298
139SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06151889
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06121243
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06082395
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05717936
143TCF4_22108803_ChIP-Seq_LS180_Human1.04486842
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.03766522
145FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03766522
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03402636
147NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02769689
148SOX2_19829295_ChIP-Seq_ESCs_Human1.00610220
149NANOG_19829295_ChIP-Seq_ESCs_Human1.00610220
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99583263
151* NANOG_16153702_ChIP-ChIP_HESCs_Human0.98554513
152SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97540563
153FOXP3_21729870_ChIP-Seq_TREG_Human0.97147291
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94336245
155CBP_20019798_ChIP-Seq_JUKART_Human0.94336245
156E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93765593
157REST_18959480_ChIP-ChIP_MESCs_Mouse0.93061635
158BCAT_22108803_ChIP-Seq_LS180_Human0.92723663
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91125212
160NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91000621
161HOXB7_26014856_ChIP-Seq_BT474_Human0.88556644
162* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88097801
163KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87960580
164GABP_19822575_ChIP-Seq_HepG2_Human0.87000281
165SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86336820
166* ESR1_21235772_ChIP-Seq_MCF-7_Human0.86113701
167* GATA3_21878914_ChIP-Seq_MCF-7_Human0.85516096
168FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85495886
169FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85295576
170GATA1_26923725_Chip-Seq_HPCs_Mouse0.84941783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.33432099
2MP0001188_hyperpigmentation3.28604683
3MP0001835_abnormal_antigen_presentation3.16890547
4MP0005645_abnormal_hypothalamus_physiol2.84125670
5MP0002148_abnormal_hypersensitivity_rea2.80761313
6MP0002277_abnormal_respiratory_mucosa2.61603568
7MP0002163_abnormal_gland_morphology2.55882071
8MP0003941_abnormal_skin_development2.46168197
9MP0002102_abnormal_ear_morphology2.43596256
10MP0001986_abnormal_taste_sensitivity2.36202948
11MP0003123_paternal_imprinting2.26573239
12MP0003787_abnormal_imprinting2.24373675
13MP0005387_immune_system_phenotype2.24070521
14MP0001790_abnormal_immune_system2.24070521
15MP0004381_abnormal_hair_follicle2.21391171
16MP0005379_endocrine/exocrine_gland_phen2.19433655
17MP0004147_increased_porphyrin_level2.13641444
18MP0001529_abnormal_vocalization2.12517606
19MP0005671_abnormal_response_to2.12067140
20MP0005174_abnormal_tail_pigmentation2.01765523
21MP0009379_abnormal_foot_pigmentation2.00924436
22MP0003136_yellow_coat_color2.00001403
23MP0003122_maternal_imprinting1.94379507
24MP0009785_altered_susceptibility_to1.94343896
25MP0000569_abnormal_digit_pigmentation1.94284492
26MP0000566_synostosis1.90284805
27MP0010386_abnormal_urinary_bladder1.87568727
28MP0006292_abnormal_olfactory_placode1.83424849
29MP0000685_abnormal_immune_system1.83169384
30MP0004270_analgesia1.82910465
31MP0006072_abnormal_retinal_apoptosis1.78775071
32MP0003890_abnormal_embryonic-extraembry1.72905377
33MP0000015_abnormal_ear_pigmentation1.69906738
34MP0001346_abnormal_lacrimal_gland1.66947249
35MP0002734_abnormal_mechanical_nocicepti1.66595027
36MP0005000_abnormal_immune_tolerance1.66109174
37MP0002272_abnormal_nervous_system1.63560783
38MP0002876_abnormal_thyroid_physiology1.62061913
39MP0002938_white_spotting1.61317393
40MP0005025_abnormal_response_to1.59871807
41MP0009745_abnormal_behavioral_response1.58491397
42MP0001800_abnormal_humoral_immune1.58488661
43MP0002419_abnormal_innate_immunity1.58364617
44MP0002723_abnormal_immune_serum1.56126301
45MP0003121_genomic_imprinting1.55740282
46MP0002452_abnormal_antigen_presenting1.54691833
47MP0004742_abnormal_vestibular_system1.50994750
48MP0005451_abnormal_body_composition1.49142560
49MP0002009_preneoplasia1.48860845
50MP0005171_absent_coat_pigmentation1.47689609
51MP0002638_abnormal_pupillary_reflex1.45465632
52MP0004133_heterotaxia1.45063588
53MP0005551_abnormal_eye_electrophysiolog1.44632830
54MP0000537_abnormal_urethra_morphology1.44267356
55MP0008260_abnormal_autophagy1.43844661
56MP0002751_abnormal_autonomic_nervous1.43651427
57MP0003283_abnormal_digestive_organ1.40493066
58MP0001485_abnormal_pinna_reflex1.39560788
59MP0002064_seizures1.36418266
60MP0003635_abnormal_synaptic_transmissio1.35553577
61MP0008872_abnormal_physiological_respon1.35538174
62MP0003693_abnormal_embryo_hatching1.35500261
63MP0009764_decreased_sensitivity_to1.35261653
64MP0001819_abnormal_immune_cell1.34534865
65MP0002572_abnormal_emotion/affect_behav1.33935972
66MP0003119_abnormal_digestive_system1.33730398
67MP0001984_abnormal_olfaction1.33338361
68MP0002420_abnormal_adaptive_immunity1.31080789
69MP0003011_delayed_dark_adaptation1.30533350
70MP0002735_abnormal_chemical_nociception1.30424639
71MP0000613_abnormal_salivary_gland1.29466902
72MP0002160_abnormal_reproductive_system1.27951254
73MP0002095_abnormal_skin_pigmentation1.27041111
74MP0003195_calcinosis1.27036070
75MP0003724_increased_susceptibility_to1.26916041
76MP0005423_abnormal_somatic_nervous1.25641467
77MP0003880_abnormal_central_pattern1.25274597
78MP0002184_abnormal_innervation1.25071320
79MP0003937_abnormal_limbs/digits/tail_de1.24427070
80MP0002909_abnormal_adrenal_gland1.23709205
81MP0005187_abnormal_penis_morphology1.23706946
82MP0000778_abnormal_nervous_system1.23695197
83MP0001293_anophthalmia1.23502138
84MP0008057_abnormal_DNA_replication1.23255907
85MP0004043_abnormal_pH_regulation1.22638460
86MP0003436_decreased_susceptibility_to1.22249393
87MP0003567_abnormal_fetal_cardiomyocyte1.22087522
88MP0000372_irregular_coat_pigmentation1.20954781
89MP0002557_abnormal_social/conspecific_i1.20388012
90MP0005409_darkened_coat_color1.19299685
91MP0005253_abnormal_eye_physiology1.18483023
92MP0000647_abnormal_sebaceous_gland1.18202525
93MP0004510_myositis1.17346007
94MP0000579_abnormal_nail_morphology1.17240910
95MP0000383_abnormal_hair_follicle1.16786159
96MP0006276_abnormal_autonomic_nervous1.16693179
97MP0000427_abnormal_hair_cycle1.15559802
98MP0002063_abnormal_learning/memory/cond1.14913223
99MP0002653_abnormal_ependyma_morphology1.14324395
100MP0005310_abnormal_salivary_gland1.13093808
101MP0009046_muscle_twitch1.11793252
102MP0000631_abnormal_neuroendocrine_gland1.11373064
103MP0001348_abnormal_lacrimal_gland1.10286272
104MP0005410_abnormal_fertilization1.09852159
105MP0003718_maternal_effect1.09173068
106MP0006035_abnormal_mitochondrial_morpho1.08422953
107MP0001970_abnormal_pain_threshold1.04807757
108MP0002090_abnormal_vision1.01309788
109MP0001727_abnormal_embryo_implantation1.01171606
110MP0000490_abnormal_crypts_of1.00981223
111MP0004885_abnormal_endolymph1.00183756
112MP0001486_abnormal_startle_reflex1.00158001
113MP0005646_abnormal_pituitary_gland1.00004189
114MP0000538_abnormal_urinary_bladder0.99377115
115MP0001968_abnormal_touch/_nociception0.98912074
116MP0002822_catalepsy0.98815109
117MP0008875_abnormal_xenobiotic_pharmacok0.98233664
118MP0000026_abnormal_inner_ear0.97856237
119MP0002006_tumorigenesis0.97365304
120MP0005394_taste/olfaction_phenotype0.96800207
121MP0005499_abnormal_olfactory_system0.96800207
122MP0001440_abnormal_grooming_behavior0.96537496
123MP0001502_abnormal_circadian_rhythm0.94572139
124MP0003183_abnormal_peptide_metabolism0.94296600
125MP0002837_dystrophic_cardiac_calcinosis0.93998597
126MP0004924_abnormal_behavior0.93860694
127MP0005386_behavior/neurological_phenoty0.93860694
128MP0005075_abnormal_melanosome_morpholog0.93163118
129MP0010234_abnormal_vibrissa_follicle0.92538228
130MP0005085_abnormal_gallbladder_physiolo0.91164401
131MP0004859_abnormal_synaptic_plasticity0.90767825
132MP0008058_abnormal_DNA_repair0.90612154
133MP0001919_abnormal_reproductive_system0.89799726
134MP0004957_abnormal_blastocyst_morpholog0.88370540
135MP0002928_abnormal_bile_duct0.86429608
136MP0008877_abnormal_DNA_methylation0.85666245
137MP0002752_abnormal_somatic_nervous0.85261313
138MP0005389_reproductive_system_phenotype0.84903535
139MP0005670_abnormal_white_adipose0.84425968
140MP0000955_abnormal_spinal_cord0.84262191
141MP0006082_CNS_inflammation0.83892908
142MP0000716_abnormal_immune_system0.83748353
143MP0004782_abnormal_surfactant_physiolog0.83140690
144MP0008004_abnormal_stomach_pH0.83044783
145MP0002229_neurodegeneration0.82192770
146MP0002098_abnormal_vibrissa_morphology0.81889343
147MP0002733_abnormal_thermal_nociception0.80497522
148MP0002882_abnormal_neuron_morphology0.80321024
149MP0004215_abnormal_myocardial_fiber0.80260918
150MP0001873_stomach_inflammation0.79568144
151MP0003763_abnormal_thymus_physiology0.79542353
152MP0004142_abnormal_muscle_tone0.79400105
153MP0000049_abnormal_middle_ear0.79312587
154MP0000470_abnormal_stomach_morphology0.78958799
155MP0004019_abnormal_vitamin_homeostasis0.78765603
156MP0001501_abnormal_sleep_pattern0.78692137
157MP0008789_abnormal_olfactory_epithelium0.78374654
158MP0002693_abnormal_pancreas_physiology0.77776796
159MP0010155_abnormal_intestine_physiology0.76631105
160MP0002405_respiratory_system_inflammati0.76209799
161MP0002166_altered_tumor_susceptibility0.75551141
162MP0005464_abnormal_platelet_physiology0.73860816
163MP0001186_pigmentation_phenotype0.73347771
164MP0002254_reproductive_system_inflammat0.72017846
165MP0008995_early_reproductive_senescence0.71079644
166MP0001845_abnormal_inflammatory_respons0.70357260
167MP0005647_abnormal_sex_gland0.69902271
168MP0002736_abnormal_nociception_after0.69794487
169MP0001963_abnormal_hearing_physiology0.69184580
170MP0003303_peritoneal_inflammation0.67965579
171MP0002067_abnormal_sensory_capabilities0.67079033
172MP0002398_abnormal_bone_marrow0.66825761
173MP0002998_abnormal_bone_remodeling0.66101459

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.67437696
2Chromsome breakage (HP:0040012)5.00984137
3Optic neuritis (HP:0100653)3.91851961
4Retrobulbar optic neuritis (HP:0100654)3.91851961
5Prostate neoplasm (HP:0100787)3.66008845
6Febrile seizures (HP:0002373)3.31024576
7Absent/shortened dynein arms (HP:0200106)3.28363973
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.28363973
9Duplicated collecting system (HP:0000081)3.24212117
10Recurrent abscess formation (HP:0002722)3.17780650
11Upper limb muscle weakness (HP:0003484)3.13349153
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.09842979
13Orchitis (HP:0100796)3.08657975
14Eczematoid dermatitis (HP:0000976)3.04023863
15Abnormal ciliary motility (HP:0012262)3.03758631
16Acute necrotizing encephalopathy (HP:0006965)3.02108909
17Recurrent bacterial skin infections (HP:0005406)2.96554287
18Abnormality of the renal collecting system (HP:0004742)2.91210536
19Acute encephalopathy (HP:0006846)2.89696113
20Myokymia (HP:0002411)2.85993803
21Myositis (HP:0100614)2.81646083
22Pancreatic cysts (HP:0001737)2.76236669
23Decreased central vision (HP:0007663)2.73779779
24Pancreatic fibrosis (HP:0100732)2.68148298
25Abnormal respiratory motile cilium morphology (HP:0005938)2.65083969
26Abnormal respiratory epithelium morphology (HP:0012253)2.65083969
27Abnormal mitochondria in muscle tissue (HP:0008316)2.65020002
28Chronic mucocutaneous candidiasis (HP:0002728)2.62656517
29Recurrent cutaneous fungal infections (HP:0011370)2.62656517
30Chronic obstructive pulmonary disease (HP:0006510)2.62456256
31Obstructive lung disease (HP:0006536)2.62456256
32Congenital sensorineural hearing impairment (HP:0008527)2.62193505
33Progressive macrocephaly (HP:0004481)2.61191577
34Abnormal respiratory motile cilium physiology (HP:0012261)2.60922491
35Clubbing of toes (HP:0100760)2.57900312
36Increased IgM level (HP:0003496)2.57199205
37Mitochondrial inheritance (HP:0001427)2.55316731
38Hyperglycinemia (HP:0002154)2.55290957
39Increased CSF lactate (HP:0002490)2.54481187
40Parakeratosis (HP:0001036)2.54093740
41Abnormality of the preputium (HP:0100587)2.53209086
42Limb dystonia (HP:0002451)2.46822748
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.45754379
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.45472996
45Stomatitis (HP:0010280)2.45307708
46Congenital stationary night blindness (HP:0007642)2.42282999
47Abnormality of DNA repair (HP:0003254)2.39843248
48Hypothermia (HP:0002045)2.37955469
49Gait imbalance (HP:0002141)2.36029212
50Mediastinal lymphadenopathy (HP:0100721)2.35789123
51Increased hepatocellular lipid droplets (HP:0006565)2.35463742
52Meningitis (HP:0001287)2.33633637
53Molar tooth sign on MRI (HP:0002419)2.33226837
54Abnormality of midbrain morphology (HP:0002418)2.33226837
55Recurrent pneumonia (HP:0006532)2.32535132
56Recurrent fungal infections (HP:0002841)2.32488772
57Hyperglycinuria (HP:0003108)2.32185161
58Lipid accumulation in hepatocytes (HP:0006561)2.31752842
59Vasculitis (HP:0002633)2.31373901
60Abnormality of the labia minora (HP:0012880)2.30723571
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.30414799
62Hypoglycemic coma (HP:0001325)2.29445413
63Basal ganglia calcification (HP:0002135)2.28254025
64Decreased circulating renin level (HP:0003351)2.28091505
65White forelock (HP:0002211)2.27671797
66Focal motor seizures (HP:0011153)2.25284851
67Septo-optic dysplasia (HP:0100842)2.23411501
68Absent rod-and cone-mediated responses on ERG (HP:0007688)2.23048557
69Congenital primary aphakia (HP:0007707)2.22856833
70Abnormality of the prostate (HP:0008775)2.22577906
71Rhinitis (HP:0012384)2.22340760
72Hepatic necrosis (HP:0002605)2.22329401
73Anhidrosis (HP:0000970)2.21648837
74Type II lissencephaly (HP:0007260)2.21503406
75Alveolar cell carcinoma (HP:0006519)2.20631901
76Chronic bronchitis (HP:0004469)2.20011747
77Genital tract atresia (HP:0001827)2.17560603
78Vaginal atresia (HP:0000148)2.15080437
79Abnormality of glycine metabolism (HP:0010895)2.14078067
80Abnormality of serine family amino acid metabolism (HP:0010894)2.14078067
81Recurrent skin infections (HP:0001581)2.13931020
82Concave nail (HP:0001598)2.13822672
83Reticulocytopenia (HP:0001896)2.13344184
84Cerebral edema (HP:0002181)2.13091946
85Lip pit (HP:0100267)2.12946090
86Keratoconjunctivitis sicca (HP:0001097)2.12414597
87Aplasia cutis congenita (HP:0001057)2.11304659
88Gingivitis (HP:0000230)2.11226821
89Patchy hypopigmentation of hair (HP:0011365)2.11117078
90Encephalitis (HP:0002383)2.10000972
91Agammaglobulinemia (HP:0004432)2.09953359
92Nephrogenic diabetes insipidus (HP:0009806)2.09368845
93Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.08987364
94Decreased activity of mitochondrial respiratory chain (HP:0008972)2.08987364
95Hepatocellular necrosis (HP:0001404)2.06850779
96Renal cortical cysts (HP:0000803)2.06787173
97Abnormality of alanine metabolism (HP:0010916)2.05742066
98Hyperalaninemia (HP:0003348)2.05742066
99Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05742066
1003-Methylglutaconic aciduria (HP:0003535)2.05542125
101Meckel diverticulum (HP:0002245)2.05128674
102Distal lower limb muscle weakness (HP:0009053)2.04348051
103Hyperinsulinemic hypoglycemia (HP:0000825)2.04243095
104Poor suck (HP:0002033)1.99538242
105Keratoconjunctivitis (HP:0001096)1.99449119
106Colon cancer (HP:0003003)1.99033173
107Ectopic kidney (HP:0000086)1.98141245
108Sclerocornea (HP:0000647)1.97920880
109Abnormality of renin-angiotensin system (HP:0000847)1.97721961
110Abnormality of calcium-phosphate metabolism (HP:0100530)1.96843335
111Hyperphosphatemia (HP:0002905)1.96619943
112Duplication of thumb phalanx (HP:0009942)1.95782656
113Abnormality of the ileum (HP:0001549)1.93739176
114Abnormality of macrophages (HP:0004311)1.93419955
115Recurrent gram-negative bacterial infections (HP:0005420)1.93123807
116Bifid tongue (HP:0010297)1.91726687
117Large for gestational age (HP:0001520)1.91589101
118Recurrent sinusitis (HP:0011108)1.91295759
119Bilateral microphthalmos (HP:0007633)1.90808727
120Optic nerve hypoplasia (HP:0000609)1.90653340
121Recurrent lower respiratory tract infections (HP:0002783)1.90637890
122Methylmalonic acidemia (HP:0002912)1.90050560
123Mesomelia (HP:0003027)1.89969972
124Atonic seizures (HP:0010819)1.89876255
125Hyperactive renin-angiotensin system (HP:0000841)1.89519312
126Abnormality of serum amino acid levels (HP:0003112)1.88574626
127Breast carcinoma (HP:0003002)1.87940129
128Tubulointerstitial nephritis (HP:0001970)1.87402924
129Xerostomia (HP:0000217)1.87011155
130Neoplasm of the tracheobronchial system (HP:0100552)1.85935683
131Abnormality of the renal cortex (HP:0011035)1.85818488
132Medial flaring of the eyebrow (HP:0010747)1.85607973
133Hypoglycemic seizures (HP:0002173)1.85246036
134Glycosuria (HP:0003076)1.85181683
135Abnormality of urine glucose concentration (HP:0011016)1.85181683
136Intestinal atresia (HP:0011100)1.83809786
137Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82599317
138Occipital encephalocele (HP:0002085)1.82461249
139Panhypogammaglobulinemia (HP:0003139)1.81913845
140Premature loss of primary teeth (HP:0006323)1.81804120
141Lactic acidosis (HP:0003128)1.81698268
142Increased serum lactate (HP:0002151)1.80186559
143True hermaphroditism (HP:0010459)1.79970022
144Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79732227
145Aplasia/hypoplasia of the uterus (HP:0008684)1.79619923
146Attenuation of retinal blood vessels (HP:0007843)1.79141749
147Lethargy (HP:0001254)1.78899853
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.78687716
149Pulmonary infiltrates (HP:0002113)1.78502326
150Retinal dysplasia (HP:0007973)1.78261910
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77777027
152Hypomagnesemia (HP:0002917)1.77740590
153Nephronophthisis (HP:0000090)1.76935665
154Polyphagia (HP:0002591)1.76008679
155Abnormality of magnesium homeostasis (HP:0004921)1.75500580
156Cheilitis (HP:0100825)1.75450095
157Elevated erythrocyte sedimentation rate (HP:0003565)1.75389276
158Chronic sinusitis (HP:0011109)1.74881543
159Anencephaly (HP:0002323)1.74543970
160Abnormality of chromosome stability (HP:0003220)1.74024042
161Male pseudohermaphroditism (HP:0000037)1.73528526
162Chronic diarrhea (HP:0002028)1.72869592
163Abnormality of the renal medulla (HP:0100957)1.70728221
164Renal Fanconi syndrome (HP:0001994)1.70275622
165Absent eyebrow (HP:0002223)1.70131860
166Lower limb amyotrophy (HP:0007210)1.69250266
167Distal lower limb amyotrophy (HP:0008944)1.68931153
168Leukodystrophy (HP:0002415)1.68928447
169Hypoplasia of the fovea (HP:0007750)1.67289987
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.67289987
171Broad-based gait (HP:0002136)1.67287357
172Hyperphosphaturia (HP:0003109)1.67137195
173Osteomalacia (HP:0002749)1.66299141
174Gangrene (HP:0100758)1.65784543
175Specific learning disability (HP:0001328)1.65672922
176Abnormality of the pons (HP:0007361)1.65668515
177Dialeptic seizures (HP:0011146)1.63953654
178Aplasia/Hypoplasia of the sacrum (HP:0008517)1.63610106
179Anophthalmia (HP:0000528)1.63035956
180Methylmalonic aciduria (HP:0012120)1.62475319
181Focal seizures (HP:0007359)1.62420531
182Optic disc pallor (HP:0000543)1.61489893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.95459022
2MAP3K143.56736541
3IRAK33.56733389
4IRAK42.98237831
5EIF2AK22.80487259
6BLK2.47151719
7STK162.38994664
8TRIM282.33383434
9TSSK62.28171663
10TXK2.26921731
11ACVR1B2.20383183
12GRK12.20051779
13ZAK2.16863156
14WNK32.14289152
15IKBKB2.14145777
16BMPR22.13159401
17IRAK12.05128707
18TNIK2.02381517
19ADRBK22.02308065
20TAOK31.99839242
21RIPK41.89887716
22WNK41.82622994
23STK391.79068048
24SIK31.75445373
25INSRR1.73140741
26MAP4K21.71573178
27IRAK21.62177717
28MAP3K41.60288003
29YES11.55138230
30OXSR11.52258999
31PIK3CG1.50732306
32BMPR1B1.50457198
33TTK1.45130339
34IKBKE1.45025451
35TEC1.44753160
36JAK11.42673082
37FGFR21.39010163
38GRK71.36355993
39CSNK1G21.36340574
40DYRK21.34665644
41PNCK1.33816508
42PLK31.32739292
43NUAK11.31890495
44CSNK1G31.29865868
45EPHA31.29050995
46CHUK1.28541163
47MUSK1.28169276
48DAPK21.27162386
49MINK11.27154196
50CSNK1G11.24892374
51NTRK31.23908368
52PINK11.21085262
53TBK11.18876370
54PKN11.18772415
55JAK31.18582692
56NME11.15704532
57MAP3K131.12453317
58PRPF4B1.11519846
59MKNK11.09381299
60EPHA41.08309512
61NEK61.05727417
62KIT1.05241923
63PDK21.04999131
64BUB11.04183690
65CAMKK21.03748769
66NLK1.02700254
67MAP2K71.02565970
68WEE11.02161724
69PRKCG1.02070782
70MAP3K91.01437657
71CDK31.00217446
72TYK20.98027327
73MARK10.96594042
74BCKDK0.96319031
75STK38L0.95807018
76RPS6KA40.94400686
77TNK20.93855295
78VRK20.93596501
79PLK10.89755443
80SYK0.89321039
81CLK10.87672231
82PAK30.86758620
83CDC70.86449794
84PRKCE0.86094298
85EPHA20.84035624
86SIK20.82925617
87NEK90.82328720
88DYRK30.81099990
89NTRK20.81079002
90PHKG20.80438038
91PHKG10.80438038
92NEK10.78476461
93BRSK20.78027785
94LIMK10.76752931
95CSNK1A1L0.76665470
96PRKCI0.76567578
97PASK0.76348523
98MST40.75712708
99LYN0.74917497
100CDK190.73544775
101MKNK20.73384636
102MAP4K10.70748379
103MAPK130.69955024
104FES0.69489927
105EIF2AK30.69486040
106BCR0.67786777
107PRKCQ0.66768157
108TRPM70.66145150
109FRK0.65972420
110EIF2AK10.65770950
111SGK20.64993513
112HCK0.64403716
113PIM20.64036365
114MST1R0.62429302
115CSNK1A10.62323532
116CAMK2D0.60818280
117NME20.57581488
118CSNK1E0.57035254
119STK240.56409891
120PBK0.54998752
121BRD40.54986829
122PIM10.54404701
123SCYL20.54145453
124LCK0.54008272
125TLK10.53535462
126VRK10.52539472
127CAMKK10.51119095
128CDK90.50557195
129PRKG20.50307838
130MAP2K20.50252131
131MAPK150.50161060
132BTK0.49750076
133MAP2K60.49616078
134CHEK20.49293725
135PLK40.48829189
136PIK3CA0.48003681
137PKN20.45906949
138ERBB30.45598388
139EPHB20.45046673
140ABL10.44802648
141DAPK10.44544065
142RPS6KA50.44257013
143CSNK2A10.44112245
144PRKCD0.43154922
145PRKD20.42673448
146CSNK2A20.42376010
147CSF1R0.42211182
148TESK10.42162855
149ADRBK10.40660276
150CAMK10.40038105
151CSK0.39994367
152SRPK10.39831675
153CAMK2A0.38761219
154CAMK2G0.38510813
155STK40.38175434
156MATK0.37545087
157CSNK1D0.37277839
158DYRK1A0.36559898
159STK110.35517017
160SGK10.33855190
161PLK20.33424852
162MAP3K120.31178196
163PRKACA0.30333520
164FLT30.28556680
165AKT10.28024854
166PRKG10.27004091
167MAPK70.26819180
168HIPK20.25436185
169ATR0.25242483

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.09047066
2Allograft rejection_Homo sapiens_hsa053302.76067879
3Parkinsons disease_Homo sapiens_hsa050122.56672568
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53903043
5Graft-versus-host disease_Homo sapiens_hsa053322.50547114
6Protein export_Homo sapiens_hsa030602.44551073
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.37083863
8Autoimmune thyroid disease_Homo sapiens_hsa053202.21581331
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.13782834
10Nitrogen metabolism_Homo sapiens_hsa009102.13619290
11Ribosome_Homo sapiens_hsa030102.06598976
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06131866
13Huntingtons disease_Homo sapiens_hsa050162.00828827
14Steroid biosynthesis_Homo sapiens_hsa001001.91795865
15Alzheimers disease_Homo sapiens_hsa050101.79257729
16Butanoate metabolism_Homo sapiens_hsa006501.76705143
17Primary immunodeficiency_Homo sapiens_hsa053401.76028106
18Proteasome_Homo sapiens_hsa030501.75360756
19Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.72156120
20Type I diabetes mellitus_Homo sapiens_hsa049401.70280002
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69598271
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68965233
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65710705
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62871922
25Phototransduction_Homo sapiens_hsa047441.59044746
26Measles_Homo sapiens_hsa051621.58250862
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57773862
28Nicotine addiction_Homo sapiens_hsa050331.56823302
29Cardiac muscle contraction_Homo sapiens_hsa042601.55877402
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55473904
31Rheumatoid arthritis_Homo sapiens_hsa053231.53965787
32Fanconi anemia pathway_Homo sapiens_hsa034601.51552003
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.51034082
34Leishmaniasis_Homo sapiens_hsa051401.49410998
35Propanoate metabolism_Homo sapiens_hsa006401.49369258
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.48071407
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47136435
38RNA polymerase_Homo sapiens_hsa030201.43444119
39Sphingolipid metabolism_Homo sapiens_hsa006001.41654876
40Morphine addiction_Homo sapiens_hsa050321.40564266
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40043814
42Sulfur metabolism_Homo sapiens_hsa009201.38971552
43Taste transduction_Homo sapiens_hsa047421.35342027
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34956653
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33839048
46Asthma_Homo sapiens_hsa053101.33615134
47Hematopoietic cell lineage_Homo sapiens_hsa046401.33335602
48Arachidonic acid metabolism_Homo sapiens_hsa005901.32814825
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30835823
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29046909
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28550600
52Fatty acid elongation_Homo sapiens_hsa000621.27101714
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26433247
54Vitamin B6 metabolism_Homo sapiens_hsa007501.25771557
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23125210
56Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23088638
57TNF signaling pathway_Homo sapiens_hsa046681.22634397
58Chemokine signaling pathway_Homo sapiens_hsa040621.21155587
59Serotonergic synapse_Homo sapiens_hsa047261.18946438
60Linoleic acid metabolism_Homo sapiens_hsa005911.18937583
61Osteoclast differentiation_Homo sapiens_hsa043801.15723997
62Fat digestion and absorption_Homo sapiens_hsa049751.14954566
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13855920
64Caffeine metabolism_Homo sapiens_hsa002321.13620614
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10648592
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.10325426
67Other glycan degradation_Homo sapiens_hsa005111.08979499
68Arginine and proline metabolism_Homo sapiens_hsa003301.08515334
69Selenocompound metabolism_Homo sapiens_hsa004501.08336386
70Herpes simplex infection_Homo sapiens_hsa051681.07720573
71Olfactory transduction_Homo sapiens_hsa047401.07327126
72Influenza A_Homo sapiens_hsa051641.06497232
73Tryptophan metabolism_Homo sapiens_hsa003801.06335134
74Pyruvate metabolism_Homo sapiens_hsa006201.05660107
75Ether lipid metabolism_Homo sapiens_hsa005651.04887635
76Malaria_Homo sapiens_hsa051441.04729692
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04203632
78Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01280467
79Basal transcription factors_Homo sapiens_hsa030220.99289631
80RNA degradation_Homo sapiens_hsa030180.98131255
81Tuberculosis_Homo sapiens_hsa051520.97395616
82Peroxisome_Homo sapiens_hsa041460.97026720
83Synaptic vesicle cycle_Homo sapiens_hsa047210.96485478
84Sulfur relay system_Homo sapiens_hsa041220.95104024
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93560939
86Collecting duct acid secretion_Homo sapiens_hsa049660.93504817
87Chemical carcinogenesis_Homo sapiens_hsa052040.93499863
88Pertussis_Homo sapiens_hsa051330.92939014
89Glutathione metabolism_Homo sapiens_hsa004800.91465022
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91464127
91Mineral absorption_Homo sapiens_hsa049780.90136026
92African trypanosomiasis_Homo sapiens_hsa051430.89974706
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89902207
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88722334
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87540486
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87350932
97Folate biosynthesis_Homo sapiens_hsa007900.86968634
98Ovarian steroidogenesis_Homo sapiens_hsa049130.86682366
99RNA transport_Homo sapiens_hsa030130.86070529
100Inositol phosphate metabolism_Homo sapiens_hsa005620.85713749
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.85581492
102Mismatch repair_Homo sapiens_hsa034300.85035892
103Homologous recombination_Homo sapiens_hsa034400.84595188
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84298005
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83697822
106Calcium signaling pathway_Homo sapiens_hsa040200.82253097
107Glutamatergic synapse_Homo sapiens_hsa047240.81875680
108Metabolic pathways_Homo sapiens_hsa011000.81839971
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81706385
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81695762
111Retinol metabolism_Homo sapiens_hsa008300.80852484
112Fatty acid metabolism_Homo sapiens_hsa012120.80617179
113One carbon pool by folate_Homo sapiens_hsa006700.79967171
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78726700
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78562707
116Toxoplasmosis_Homo sapiens_hsa051450.77997615
117B cell receptor signaling pathway_Homo sapiens_hsa046620.77844251
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.77330885
119Prolactin signaling pathway_Homo sapiens_hsa049170.76924481
120Phagosome_Homo sapiens_hsa041450.76662136
121beta-Alanine metabolism_Homo sapiens_hsa004100.76592815
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74821901
123Type II diabetes mellitus_Homo sapiens_hsa049300.72531811
124Fatty acid degradation_Homo sapiens_hsa000710.70512783
125Pyrimidine metabolism_Homo sapiens_hsa002400.70195286
126Purine metabolism_Homo sapiens_hsa002300.69630323
127Renin secretion_Homo sapiens_hsa049240.68136290
128Circadian entrainment_Homo sapiens_hsa047130.66617216
129Base excision repair_Homo sapiens_hsa034100.65659653
130Dopaminergic synapse_Homo sapiens_hsa047280.65614828
131Regulation of autophagy_Homo sapiens_hsa041400.65392301
132ABC transporters_Homo sapiens_hsa020100.65284704
133Non-homologous end-joining_Homo sapiens_hsa034500.65022399
134Spliceosome_Homo sapiens_hsa030400.64646905
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62683333
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62433060
137Histidine metabolism_Homo sapiens_hsa003400.61817669
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59974652
139Cocaine addiction_Homo sapiens_hsa050300.59963290
140Apoptosis_Homo sapiens_hsa042100.59790605
141Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58229640
142cAMP signaling pathway_Homo sapiens_hsa040240.55601308
143Hepatitis C_Homo sapiens_hsa051600.55092372
144Long-term depression_Homo sapiens_hsa047300.54638304
145T cell receptor signaling pathway_Homo sapiens_hsa046600.53614618
146Arginine biosynthesis_Homo sapiens_hsa002200.53465639
147Cholinergic synapse_Homo sapiens_hsa047250.53374710
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.52893568
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52650723
150Vitamin digestion and absorption_Homo sapiens_hsa049770.51339662
151Insulin secretion_Homo sapiens_hsa049110.48655037
152Staphylococcus aureus infection_Homo sapiens_hsa051500.48571104
153DNA replication_Homo sapiens_hsa030300.48192087
154Viral myocarditis_Homo sapiens_hsa054160.47905617
155Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46930367
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46772589
157Steroid hormone biosynthesis_Homo sapiens_hsa001400.45893449
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45598971
159Legionellosis_Homo sapiens_hsa051340.44282358
160Maturity onset diabetes of the young_Homo sapiens_hsa049500.43256342
161Hepatitis B_Homo sapiens_hsa051610.40996792
162Salivary secretion_Homo sapiens_hsa049700.40432527
163Ras signaling pathway_Homo sapiens_hsa040140.39964649
164Platelet activation_Homo sapiens_hsa046110.38094190
165Salmonella infection_Homo sapiens_hsa051320.37509924
166p53 signaling pathway_Homo sapiens_hsa041150.37267494
167GABAergic synapse_Homo sapiens_hsa047270.35370539
168Amphetamine addiction_Homo sapiens_hsa050310.35357129
169Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35211949
170Vibrio cholerae infection_Homo sapiens_hsa051100.34425132
171Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34415515
172Axon guidance_Homo sapiens_hsa043600.34279834

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