PKIG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.40748002
2cardiac myofibril assembly (GO:0055003)7.11587233
3muscle filament sliding (GO:0030049)6.39695278
4actin-myosin filament sliding (GO:0033275)6.39695278
5myofibril assembly (GO:0030239)6.27728794
6cardiac muscle contraction (GO:0060048)5.75670129
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.74700101
8tricarboxylic acid cycle (GO:0006099)5.42830800
9negative regulation of potassium ion transmembrane transport (GO:1901380)5.23563051
10cardiac muscle cell development (GO:0055013)5.16211403
11heart trabecula formation (GO:0060347)5.12803451
12actin-mediated cell contraction (GO:0070252)5.10839640
13cytidine deamination (GO:0009972)5.08524810
14cytidine metabolic process (GO:0046087)5.08524810
15cytidine catabolic process (GO:0006216)5.08524810
16regulation of sarcomere organization (GO:0060297)5.02053106
17axonemal dynein complex assembly (GO:0070286)4.91963180
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.90484093
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.84667692
20regulation of relaxation of muscle (GO:1901077)4.81549634
21cardiac cell development (GO:0055006)4.79807885
22ATP synthesis coupled proton transport (GO:0015986)4.78417788
23energy coupled proton transport, down electrochemical gradient (GO:0015985)4.78417788
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.73278101
25striated muscle contraction (GO:0006941)4.68682188
26actomyosin structure organization (GO:0031032)4.66289291
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.63514923
28oxidative phosphorylation (GO:0006119)4.63262699
29cardiac muscle hypertrophy (GO:0003300)4.56575713
30plasma membrane repair (GO:0001778)4.56567906
31regulation of actin filament-based movement (GO:1903115)4.50256000
32heart process (GO:0003015)4.49920964
33heart contraction (GO:0060047)4.49920964
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.49111364
35regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.41652065
36cardiac muscle tissue morphogenesis (GO:0055008)4.36869621
37regulation of skeletal muscle contraction (GO:0014819)4.33973367
38pyrimidine ribonucleoside catabolic process (GO:0046133)4.32419366
39striated muscle hypertrophy (GO:0014897)4.29085161
40respiratory electron transport chain (GO:0022904)4.26434721
41electron transport chain (GO:0022900)4.17624725
42ventricular cardiac muscle cell action potential (GO:0086005)4.16901383
43regulation of cell communication by electrical coupling (GO:0010649)4.14144650
44calcium-mediated signaling using intracellular calcium source (GO:0035584)4.10446606
45regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.09651925
46ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.06647967
47NADH metabolic process (GO:0006734)4.03717773
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.03096185
49adult heart development (GO:0007512)4.00844731
50negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.97739204
51muscle tissue morphogenesis (GO:0060415)3.97246881
52regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.95609261
53protein neddylation (GO:0045116)3.93101620
54muscle hypertrophy (GO:0014896)3.90572721
55regulation of the force of heart contraction (GO:0002026)3.89822838
56sarcoplasmic reticulum calcium ion transport (GO:0070296)3.89061931
57regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.80490118
58regulation of striated muscle contraction (GO:0006942)3.79194951
59cilium movement (GO:0003341)3.69710864
60ventricular cardiac muscle cell development (GO:0055015)3.67188707
61regulation of membrane repolarization (GO:0060306)3.66764020
62actin filament-based movement (GO:0030048)3.65225982
63epithelial cilium movement (GO:0003351)3.62878258
64regulation of acyl-CoA biosynthetic process (GO:0050812)3.57273435
65bundle of His cell to Purkinje myocyte communication (GO:0086069)3.56270253
66endothelium development (GO:0003158)3.55430169
67cellular response to zinc ion (GO:0071294)3.54295334
68blood vessel maturation (GO:0001955)3.46296381
69extracellular fibril organization (GO:0043206)3.45115087
70ATP biosynthetic process (GO:0006754)3.43474923
71regulation of cofactor metabolic process (GO:0051193)3.41733506
72regulation of coenzyme metabolic process (GO:0051196)3.41733506
73regulation of ATPase activity (GO:0043462)3.40169460
74regulation of ATP catabolic process (GO:1903289)3.40169460
75negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.37297493
76negative regulation of calcium ion transmembrane transport (GO:1903170)3.37297493
77cardiac muscle hypertrophy in response to stress (GO:0014898)3.32563133
78muscle hypertrophy in response to stress (GO:0003299)3.32563133
79cardiac muscle adaptation (GO:0014887)3.32563133
80skeletal muscle contraction (GO:0003009)3.29610251
81regulation of integrin-mediated signaling pathway (GO:2001044)3.22233077
82left/right pattern formation (GO:0060972)3.17565551
83striated muscle cell development (GO:0055002)3.17498473
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11703069
85negative regulation of potassium ion transport (GO:0043267)3.10501019
86pattern specification involved in kidney development (GO:0061004)3.04334683
87regulation of heart rate (GO:0002027)3.04070183
88purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.03180506
89negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.02377031
90potassium ion export (GO:0071435)2.97590776
91cardiac muscle cell action potential involved in contraction (GO:0086002)2.96770529
92cell communication involved in cardiac conduction (GO:0086065)2.96494030
93purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95164574
94regulation of cardiac muscle cell contraction (GO:0086004)2.95123785
95axoneme assembly (GO:0035082)2.94252667
96motile cilium assembly (GO:0044458)2.91109568
97trabecula formation (GO:0060343)2.88656281
98negative regulation of cation channel activity (GO:2001258)2.87404475
99muscle contraction (GO:0006936)2.86491680
100regulation of cilium movement (GO:0003352)2.86432779
101cardiac muscle cell action potential (GO:0086001)2.86292296
102aerobic respiration (GO:0009060)2.85970194
103positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.85267839
104negative regulation of response to food (GO:0032096)2.85196227
105negative regulation of appetite (GO:0032099)2.85196227
106negative regulation of striated muscle cell apoptotic process (GO:0010664)2.85015479
107negative regulation of protein localization to cell surface (GO:2000009)2.84252226
108protein maturation by protein folding (GO:0022417)2.82885105
109regulation of cardiac muscle contraction (GO:0055117)2.82766030
110regulation of heart contraction (GO:0008016)2.82327926
111negative regulation of heart rate (GO:0010459)2.81635811
112muscle cell development (GO:0055001)2.80237817
113quinone biosynthetic process (GO:1901663)2.80004588
114ubiquinone biosynthetic process (GO:0006744)2.80004588
115regulation of cardioblast differentiation (GO:0051890)2.79974393
116cardiac conduction (GO:0061337)2.79826719
117response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.79607217
118axon ensheathment in central nervous system (GO:0032291)2.78888409
119central nervous system myelination (GO:0022010)2.78888409
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76935683
121positive regulation of myotube differentiation (GO:0010831)2.76269354
122cardiac chamber formation (GO:0003207)2.73113911
123ribonucleoside triphosphate biosynthetic process (GO:0009201)2.72944320
124negative regulation of cardiac muscle hypertrophy (GO:0010614)2.69661161
125cilium or flagellum-dependent cell motility (GO:0001539)2.69401345
126muscle system process (GO:0003012)2.66881783
127positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.66754494
128oxygen transport (GO:0015671)2.66643151
129platelet dense granule organization (GO:0060155)2.66120632
130ribosomal small subunit assembly (GO:0000028)2.64628068
131neuronal action potential propagation (GO:0019227)2.60824019
132cell migration involved in heart development (GO:0060973)2.60573314
133fibril organization (GO:0097435)2.55493726
134type B pancreatic cell proliferation (GO:0044342)2.53943705
135negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.45644273
136membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44878767
137response to redox state (GO:0051775)2.44742458
138intraciliary transport (GO:0042073)2.42607886
139glutathione derivative biosynthetic process (GO:1901687)2.42053373
140glutathione derivative metabolic process (GO:1901685)2.42053373
141synaptic vesicle maturation (GO:0016188)2.41401453
142dendritic spine morphogenesis (GO:0060997)2.38614438
143cell communication by electrical coupling (GO:0010644)2.38523110
144lipopolysaccharide biosynthetic process (GO:0009103)2.36963065
145lymph vessel development (GO:0001945)2.36142992
146tonic smooth muscle contraction (GO:0014820)2.35709943
147pyrimidine nucleotide catabolic process (GO:0006244)2.35247334
148deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34297746
149hydrogen peroxide catabolic process (GO:0042744)2.32600848
150chaperone-mediated protein transport (GO:0072321)2.32366309
151endocardial cushion development (GO:0003197)2.31081285
152relaxation of smooth muscle (GO:0044557)2.29765148
153erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.29606389
154L-phenylalanine catabolic process (GO:0006559)2.29606389
155arginine catabolic process (GO:0006527)2.27945530
156glutamate secretion (GO:0014047)2.24295482
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.22445863
158astrocyte differentiation (GO:0048708)2.21059606
159radial glial cell differentiation (GO:0060019)2.20424442
160protein complex biogenesis (GO:0070271)2.19075925
161blood coagulation, intrinsic pathway (GO:0007597)2.15024946
162short-term memory (GO:0007614)2.13401067
163vascular endothelial growth factor signaling pathway (GO:0038084)2.11330930
164protein heterotrimerization (GO:0070208)2.11143719
165renal tubule morphogenesis (GO:0061333)2.09899741
166deoxyribonucleotide catabolic process (GO:0009264)2.09382239
167postsynaptic membrane organization (GO:0001941)2.09121586
168auditory receptor cell differentiation (GO:0042491)2.08217241
169regulation of microtubule-based movement (GO:0060632)2.07969935
170aldehyde catabolic process (GO:0046185)2.07496510
171telencephalon development (GO:0021537)2.06663853
172prostaglandin biosynthetic process (GO:0001516)2.06085719
173prostanoid biosynthetic process (GO:0046457)2.06085719
174left/right axis specification (GO:0070986)2.05453958
175L-phenylalanine metabolic process (GO:0006558)2.04512649
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.04512649
177axon extension involved in axon guidance (GO:0048846)2.02709445
178neuron projection extension involved in neuron projection guidance (GO:1902284)2.02709445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.19894228
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.11672417
3MYC_22102868_ChIP-Seq_BL_Human3.04224025
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.00300808
5E2F7_22180533_ChIP-Seq_HELA_Human2.96784733
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.84699997
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.83092311
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.80941116
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.50282158
10EZH2_22144423_ChIP-Seq_EOC_Human2.48451991
11VDR_21846776_ChIP-Seq_THP-1_Human2.42131658
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37960300
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30693737
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29122746
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27968080
16ZNF263_19887448_ChIP-Seq_K562_Human2.17556358
17CIITA_25753668_ChIP-Seq_RAJI_Human2.16575706
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12726278
19MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.10224070
20TBX20_22080862_ChIP-Seq_HEART_Mouse2.08129927
21TBX20_22328084_ChIP-Seq_HEART_Mouse2.08129927
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07838499
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07838499
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.02425567
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.99331498
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96876395
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.96703240
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96089476
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95739982
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94700589
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94573058
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93637684
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92915985
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90953904
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89591584
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.88321467
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85149422
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83546332
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.83350972
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.81025859
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.79947778
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.79194917
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.79166281
44JARID2_20064375_ChIP-Seq_MESCs_Mouse1.78682790
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78400592
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78100704
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.73443903
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69468651
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68921527
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65770336
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63955924
52GATA4_21415370_ChIP-Seq_HL-1_Mouse1.60858951
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.59634027
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.58315816
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.58226705
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.58157121
57* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57602522
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56778907
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56763307
60* SRF_21415370_ChIP-Seq_HL-1_Mouse1.53084401
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51883673
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49958148
63* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47326383
64BCL6_27268052_Chip-Seq_Bcells_Human1.46384220
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.46165580
66TCF7_22412390_ChIP-Seq_EML_Mouse1.46064546
67* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44974571
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42842711
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42674948
70MAF_26560356_Chip-Seq_TH1_Human1.42422134
71XRN2_22483619_ChIP-Seq_HELA_Human1.42075182
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41758472
73LXR_22292898_ChIP-Seq_THP-1_Human1.41065089
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41053220
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41005504
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.40403401
77KDM2B_26808549_Chip-Seq_DND41_Human1.39652103
78CTCF_27219007_Chip-Seq_Bcells_Human1.38813992
79HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36481142
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.36374023
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.35768861
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35625332
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34779865
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32897773
85DCP1A_22483619_ChIP-Seq_HELA_Human1.32696601
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32379306
87VDR_24763502_ChIP-Seq_THP-1_Human1.31725142
88BCOR_27268052_Chip-Seq_Bcells_Human1.30464512
89GATA1_22025678_ChIP-Seq_K562_Human1.29458329
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29245257
91SPI1_20517297_ChIP-Seq_HL60_Human1.28946743
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28810346
93GABP_17652178_ChIP-ChIP_JURKAT_Human1.28652908
94DROSHA_22980978_ChIP-Seq_HELA_Human1.27437831
95* SPI1_23127762_ChIP-Seq_K562_Human1.26986587
96FOXP3_21729870_ChIP-Seq_TREG_Human1.26919518
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25979787
98* UTX_26944678_Chip-Seq_JUKART_Human1.25337748
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23546231
100P68_20966046_ChIP-Seq_HELA_Human1.23214664
101RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.22425023
102TP53_20018659_ChIP-ChIP_R1E_Mouse1.22393387
103MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22290918
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.22009351
105* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21903526
106GABP_19822575_ChIP-Seq_HepG2_Human1.21624262
107SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21003163
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20997588
109SCL_19346495_ChIP-Seq_HPC-7_Human1.19604933
110CTCF_21964334_Chip-Seq_Bcells_Human1.18500564
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18349436
112MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18195968
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16342096
114TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15882278
115CTCF_26484167_Chip-Seq_Bcells_Mouse1.15079713
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14968386
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14771800
118* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14383926
119VDR_23849224_ChIP-Seq_CD4+_Human1.14217062
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.13736846
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.12498479
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.11386005
123SA1_22415368_ChIP-Seq_MEFs_Mouse1.11204662
124GBX2_23144817_ChIP-Seq_PC3_Human1.10039958
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09896767
126REST_21632747_ChIP-Seq_MESCs_Mouse1.09540970
127* MAF_26560356_Chip-Seq_TH2_Human1.08078721
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07708956
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07582009
130PHF8_20622854_ChIP-Seq_HELA_Human1.06956022
131OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06862534
132E2F1_20622854_ChIP-Seq_HELA_Human1.06709456
133CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06537389
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05511867
135REST_18959480_ChIP-ChIP_MESCs_Mouse1.04343091
136BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01244823
137* GATA2_21666600_ChIP-Seq_HMVEC_Human1.01223551
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00826190
139* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00700303
140* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99936790
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99883829
142P300_27268052_Chip-Seq_Bcells_Human0.99785465
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99659371
144* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98519434
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.97939548
146E2F1_21310950_ChIP-Seq_MCF-7_Human0.97405652
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97307263
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97074515
149GATA1_19941826_ChIP-Seq_K562_Human0.96907472
150HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96670381
151SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92173240
152EOMES_21245162_ChIP-Seq_HESCs_Human0.90716614
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90499030
154* CTCF_20526341_ChIP-Seq_ESCs_Human0.88532607
155SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86379860
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86357411
157IGF1R_20145208_ChIP-Seq_DFB_Human0.86073654
158RNF2_27304074_Chip-Seq_NSC_Mouse0.85881412
159PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85645497
160* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83192540
161TP53_23651856_ChIP-Seq_MEFs_Mouse0.80955191
162GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80308447
163ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.80061482
164* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.78898544
165TET1_21490601_ChIP-Seq_MESCs_Mouse0.78590146
166* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.77037053
167MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74726442
168KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.74551243
169BP1_19119308_ChIP-ChIP_Hs578T_Human0.73225079
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.71705994
171PIAS1_25552417_ChIP-Seq_VCAP_Human0.71000267
172UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.70957776
173ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70773147
174SOX2_21211035_ChIP-Seq_LN229_Human0.70042718
175SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.69637711
176TP53_22127205_ChIP-Seq_IMR90_Human0.69186902
177MYC_19829295_ChIP-Seq_ESCs_Human0.68386487
178CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.68242381
179PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.67439018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.93325457
2MP0002837_dystrophic_cardiac_calcinosis5.80017144
3MP0004084_abnormal_cardiac_muscle4.94548141
4MP0000751_myopathy4.81326130
5MP0000749_muscle_degeneration4.28759487
6MP0004215_abnormal_myocardial_fiber4.26170340
7MP0004036_abnormal_muscle_relaxation3.78368456
8MP0005330_cardiomyopathy3.55092094
9MP0005503_abnormal_tendon_morphology3.38880395
10MP0008438_abnormal_cutaneous_collagen2.95216053
11MP0004087_abnormal_muscle_fiber2.88880603
12MP0002972_abnormal_cardiac_muscle2.74586976
13MP0000750_abnormal_muscle_regeneration2.74330059
14MP0008775_abnormal_heart_ventricle2.63627834
15MP0004484_altered_response_of2.58583486
16MP0003828_pulmonary_edema2.47788180
17MP0002106_abnormal_muscle_physiology2.47445347
18MP0010630_abnormal_cardiac_muscle2.45712796
19MP0001544_abnormal_cardiovascular_syste2.43892964
20MP0005385_cardiovascular_system_phenoty2.43892964
21MP0005620_abnormal_muscle_contractility2.43288086
22MP0009780_abnormal_chondrocyte_physiolo2.41821610
23MP0004859_abnormal_synaptic_plasticity2.41423030
24MP0003137_abnormal_impulse_conducting2.37565183
25MP0004272_abnormal_basement_membrane2.26329530
26MP0002653_abnormal_ependyma_morphology2.22161238
27MP0006036_abnormal_mitochondrial_physio2.19934610
28MP0002269_muscular_atrophy2.13900267
29MP0006138_congestive_heart_failure2.07395281
30MP0004510_myositis1.96170832
31MP0000759_abnormal_skeletal_muscle1.95992700
32MP0004145_abnormal_muscle_electrophysio1.94068659
33MP0004085_abnormal_heartbeat1.93260523
34MP0005369_muscle_phenotype1.91534271
35MP0003186_abnormal_redox_activity1.90013417
36MP0000747_muscle_weakness1.85832059
37MP0001958_emphysema1.85127729
38MP0004233_abnormal_muscle_weight1.82269549
39MP0003221_abnormal_cardiomyocyte_apopto1.80950051
40MP0002127_abnormal_cardiovascular_syste1.75019529
41MP0002295_abnormal_pulmonary_circulatio1.72227445
42MP0009384_cardiac_valve_regurgitation1.66312156
43MP0002638_abnormal_pupillary_reflex1.65851056
44MP0003880_abnormal_central_pattern1.65347624
45MP0008004_abnormal_stomach_pH1.62303388
46MP0001968_abnormal_touch/_nociception1.60234786
47MP0003011_delayed_dark_adaptation1.58424748
48MP0001984_abnormal_olfaction1.55878124
49MP0005167_abnormal_blood-brain_barrier1.55091217
50MP0006276_abnormal_autonomic_nervous1.53441685
51MP0001905_abnormal_dopamine_level1.48283835
52MP0001879_abnormal_lymphatic_vessel1.47458453
53MP0004130_abnormal_muscle_cell1.40623691
54MP0005275_abnormal_skin_tensile1.40073899
55MP0005084_abnormal_gallbladder_morpholo1.36144657
56MP0003567_abnormal_fetal_cardiomyocyte1.35966218
57MP0003656_abnormal_erythrocyte_physiolo1.35047688
58MP0001986_abnormal_taste_sensitivity1.33833580
59MP0010368_abnormal_lymphatic_system1.33496378
60MP0010030_abnormal_orbit_morphology1.28404728
61MP0005595_abnormal_vascular_smooth1.26854832
62MP0001970_abnormal_pain_threshold1.26123969
63MP0001542_abnormal_bone_strength1.25347517
64MP0000266_abnormal_heart_morphology1.21476312
65MP0005508_abnormal_skeleton_morphology1.20969977
66MP0005464_abnormal_platelet_physiology1.20300228
67MP0003279_aneurysm1.19661262
68MP0008789_abnormal_olfactory_epithelium1.18490872
69MP0002733_abnormal_thermal_nociception1.15513569
70MP0000372_irregular_coat_pigmentation1.15349059
71MP0003635_abnormal_synaptic_transmissio1.13320307
72MP0005646_abnormal_pituitary_gland1.13234221
73MP0000049_abnormal_middle_ear1.09918078
74MP0002572_abnormal_emotion/affect_behav1.08934419
75MP0006035_abnormal_mitochondrial_morpho1.07344124
76MP0000343_altered_response_to1.06288810
77MP0002272_abnormal_nervous_system1.05430200
78MP0005410_abnormal_fertilization1.05258435
79MP0005257_abnormal_intraocular_pressure1.04585092
80MP0003693_abnormal_embryo_hatching1.04290489
81MP0009745_abnormal_behavioral_response1.03892603
82MP0002735_abnormal_chemical_nociception1.01896034
83MP0004147_increased_porphyrin_level1.00557106
84MP0002734_abnormal_mechanical_nocicepti0.99421655
85MP0004133_heterotaxia0.97525404
86MP0004808_abnormal_hematopoietic_stem0.96658424
87MP0005499_abnormal_olfactory_system0.95594318
88MP0005394_taste/olfaction_phenotype0.95594318
89MP0006054_spinal_hemorrhage0.95008780
90MP0002332_abnormal_exercise_endurance0.93654670
91MP0009379_abnormal_foot_pigmentation0.92920634
92MP0000465_gastrointestinal_hemorrhage0.90740624
93MP0010386_abnormal_urinary_bladder0.90688652
94MP0002063_abnormal_learning/memory/cond0.90613847
95MP0005551_abnormal_eye_electrophysiolog0.90002268
96MP0000013_abnormal_adipose_tissue0.89418217
97MP0002234_abnormal_pharynx_morphology0.88197042
98MP0004858_abnormal_nervous_system0.87563519
99MP0002396_abnormal_hematopoietic_system0.84509481
100MP0001529_abnormal_vocalization0.84298108
101MP0002876_abnormal_thyroid_physiology0.84029603
102MP0003077_abnormal_cell_cycle0.83929686
103MP0000767_abnormal_smooth_muscle0.83350717
104MP0005165_increased_susceptibility_to0.83099807
105MP0009697_abnormal_copulation0.82251932
106MP0009046_muscle_twitch0.81685211
107MP0002064_seizures0.81190091
108MP0003111_abnormal_nucleus_morphology0.79248211
109MP0002557_abnormal_social/conspecific_i0.78666650
110MP0001299_abnormal_eye_distance/0.78281222
111MP0002128_abnormal_blood_circulation0.78096635
112MP0005670_abnormal_white_adipose0.75726591
113MP0000778_abnormal_nervous_system0.75125261
114MP0003942_abnormal_urinary_system0.74673317
115MP0003787_abnormal_imprinting0.74538938
116MP0003122_maternal_imprinting0.73811167
117MP0001545_abnormal_hematopoietic_system0.73241918
118MP0005397_hematopoietic_system_phenotyp0.73241918
119MP0001486_abnormal_startle_reflex0.72943420
120MP0010094_abnormal_chromosome_stability0.70868436
121MP0003950_abnormal_plasma_membrane0.70763021
122MP0000230_abnormal_systemic_arterial0.70629574
123MP0001756_abnormal_urination0.70593502
124MP0001800_abnormal_humoral_immune0.70213649
125MP0005423_abnormal_somatic_nervous0.69442677
126MP0000733_abnormal_muscle_development0.69354466
127MP0001835_abnormal_antigen_presentation0.68840064
128MP0005623_abnormal_meninges_morphology0.68182917
129MP0005666_abnormal_adipose_tissue0.65905633
130MP0002398_abnormal_bone_marrow0.64969955
131MP0003984_embryonic_growth_retardation0.64254838
132MP0003879_abnormal_hair_cell0.62268914
133MP0005266_abnormal_metabolism0.61660322
134MP0002088_abnormal_embryonic_growth/wei0.59847338
135MP0000689_abnormal_spleen_morphology0.59772121
136MP0004957_abnormal_blastocyst_morpholog0.59503969
137MP0005387_immune_system_phenotype0.56766600
138MP0001790_abnormal_immune_system0.56766600
139MP0002909_abnormal_adrenal_gland0.56285538
140MP0002925_abnormal_cardiovascular_devel0.54038935
141MP0005375_adipose_tissue_phenotype0.54021610
142MP0000003_abnormal_adipose_tissue0.53705040
143MP0002722_abnormal_immune_system0.53372058
144MP0009278_abnormal_bone_marrow0.52571344
145MP0002452_abnormal_antigen_presenting0.51458815
146MP0002429_abnormal_blood_cell0.51272534
147MP0001853_heart_inflammation0.50993254
148MP0000313_abnormal_cell_death0.50964498
149MP0008877_abnormal_DNA_methylation0.50598451
150MP0003303_peritoneal_inflammation0.50491901
151MP0001730_embryonic_growth_arrest0.50081576
152MP0005451_abnormal_body_composition0.49299389
153MP0001784_abnormal_fluid_regulation0.49076849
154MP0002108_abnormal_muscle_morphology0.47753317
155MP0000716_abnormal_immune_system0.46626252
156MP0000685_abnormal_immune_system0.46251002
157MP0003123_paternal_imprinting0.45928585
158MP0001727_abnormal_embryo_implantation0.43158835
159MP0001672_abnormal_embryogenesis/_devel0.42836140
160MP0005380_embryogenesis_phenotype0.42836140
161MP0002736_abnormal_nociception_after0.42036102
162MP0000249_abnormal_blood_vessel0.41604418
163MP0001697_abnormal_embryo_size0.41590049

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.76953379
2Ventricular tachycardia (HP:0004756)5.33858214
3Calf muscle hypertrophy (HP:0008981)5.30884380
4Exercise-induced myalgia (HP:0003738)5.07883186
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.07867887
6Atrial fibrillation (HP:0005110)5.01330850
7Exercise-induced muscle cramps (HP:0003710)4.95057524
8Abnormal ciliary motility (HP:0012262)4.92717520
9Abnormal respiratory epithelium morphology (HP:0012253)4.90261943
10Abnormal respiratory motile cilium morphology (HP:0005938)4.90261943
11Abnormal respiratory motile cilium physiology (HP:0012261)4.79418935
12Muscle hypertrophy of the lower extremities (HP:0008968)4.77318061
13Primary atrial arrhythmia (HP:0001692)4.75478108
14Supraventricular tachycardia (HP:0004755)4.69583579
15Muscle fiber splitting (HP:0003555)4.64498720
16Lipoatrophy (HP:0100578)4.63267581
17Abnormality of the calf musculature (HP:0001430)4.58911829
18Supraventricular arrhythmia (HP:0005115)4.58793712
19Abnormality of the left ventricular outflow tract (HP:0011103)4.57449866
20Subaortic stenosis (HP:0001682)4.57449866
21Absent/shortened dynein arms (HP:0200106)4.22014297
22Dynein arm defect of respiratory motile cilia (HP:0012255)4.22014297
23Rhinitis (HP:0012384)4.07520360
24Bundle branch block (HP:0011710)3.93459619
25Palpitations (HP:0001962)3.86045934
26Myoglobinuria (HP:0002913)3.81367519
27EMG: myopathic abnormalities (HP:0003458)3.79230064
28Syncope (HP:0001279)3.76928458
29Dilated cardiomyopathy (HP:0001644)3.76822030
30Ventricular fibrillation (HP:0001663)3.73219694
31Asymmetric septal hypertrophy (HP:0001670)3.62756782
32Prolonged QT interval (HP:0001657)3.53931225
33Myokymia (HP:0002411)3.45419636
34Abnormal mitochondria in muscle tissue (HP:0008316)3.32324531
35Difficulty climbing stairs (HP:0003551)3.32101938
36Ventricular arrhythmia (HP:0004308)3.30788673
37Acute necrotizing encephalopathy (HP:0006965)3.28577104
38Hyporeflexia of lower limbs (HP:0002600)3.28539511
39Rhabdomyolysis (HP:0003201)3.26653980
40Agammaglobulinemia (HP:0004432)3.22854560
41Myotonia (HP:0002486)3.21262327
42Heart block (HP:0012722)3.18816100
43Right ventricular cardiomyopathy (HP:0011663)3.17882867
44Aortic aneurysm (HP:0004942)3.14811027
45Difficulty running (HP:0009046)3.12283764
46Atrioventricular block (HP:0001678)3.11795839
47Increased connective tissue (HP:0009025)3.10276603
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.09469246
49Abnormal atrioventricular conduction (HP:0005150)3.05451866
50Protrusio acetabuli (HP:0003179)3.01502096
51Hepatic necrosis (HP:0002605)2.99075169
52Muscle fiber inclusion bodies (HP:0100299)2.98794348
53Papilloma (HP:0012740)2.96033160
54Verrucae (HP:0200043)2.96033160
55Hepatocellular necrosis (HP:0001404)2.91698761
56Polyphagia (HP:0002591)2.88971768
57Mitochondrial inheritance (HP:0001427)2.87996265
58Abnormal EKG (HP:0003115)2.87168067
59Atelectasis (HP:0100750)2.77506747
60Progressive macrocephaly (HP:0004481)2.74471663
61Left ventricular hypertrophy (HP:0001712)2.73348880
62Type 1 muscle fiber predominance (HP:0003803)2.71085295
63Conjunctival hamartoma (HP:0100780)2.69191902
64Increased CSF lactate (HP:0002490)2.65671465
65Nemaline bodies (HP:0003798)2.64404247
66Purpura (HP:0000979)2.64067064
67Pancreatic fibrosis (HP:0100732)2.62534016
68Acute encephalopathy (HP:0006846)2.61979788
69Cellulitis (HP:0100658)2.59542505
70Facial diplegia (HP:0001349)2.56259666
71Occipital encephalocele (HP:0002085)2.55804929
72Exercise intolerance (HP:0003546)2.55470791
73Testicular atrophy (HP:0000029)2.54403004
74Increased muscle lipid content (HP:0009058)2.49960821
75Limb-girdle muscle atrophy (HP:0003797)2.47136208
76Prolonged bleeding time (HP:0003010)2.45828329
77Abnormality of the nasal mucosa (HP:0000433)2.44044256
78Increased intramyocellular lipid droplets (HP:0012240)2.40662773
79Ragged-red muscle fibers (HP:0003200)2.39384402
80Premature rupture of membranes (HP:0001788)2.36113518
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34734255
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34734255
83True hermaphroditism (HP:0010459)2.33766140
84Areflexia of lower limbs (HP:0002522)2.33465843
85Abnormal eating behavior (HP:0100738)2.33198670
86Neck muscle weakness (HP:0000467)2.33013499
87Menorrhagia (HP:0000132)2.32672862
88Chronic bronchitis (HP:0004469)2.31642220
89Medial flaring of the eyebrow (HP:0010747)2.30186800
90Abnormality of dentin (HP:0010299)2.30184765
91Lactic acidosis (HP:0003128)2.28942977
92Torticollis (HP:0000473)2.26605357
93Molar tooth sign on MRI (HP:0002419)2.26360454
94Abnormality of midbrain morphology (HP:0002418)2.26360454
95Craniofacial dystonia (HP:0012179)2.26220039
96Abnormality of skeletal muscle fiber size (HP:0012084)2.25202064
97Focal dystonia (HP:0004373)2.23202674
98Generalized muscle weakness (HP:0003324)2.20151845
99Spinal rigidity (HP:0003306)2.19873988
100Respiratory failure (HP:0002878)2.17679056
101Hypoplastic left heart (HP:0004383)2.17139833
102Palmoplantar keratoderma (HP:0000982)2.14854487
103Pancreatic cysts (HP:0001737)2.13662882
104Increased variability in muscle fiber diameter (HP:0003557)2.12224805
105Muscle stiffness (HP:0003552)2.10824607
106Follicular hyperkeratosis (HP:0007502)2.10373495
107Nephronophthisis (HP:0000090)2.09325932
108Vascular tortuosity (HP:0004948)2.09078563
109Gait imbalance (HP:0002141)2.08912530
110Distal lower limb amyotrophy (HP:0008944)2.07773289
111Polycythemia (HP:0001901)2.07330963
112Chronic sinusitis (HP:0011109)2.05988262
113Petechiae (HP:0000967)2.05481069
114Gastrointestinal stroma tumor (HP:0100723)2.04005671
115Recurrent bronchitis (HP:0002837)2.03627456
116Progressive muscle weakness (HP:0003323)2.03065141
117Pulmonary artery stenosis (HP:0004415)2.02463085
118Cerebral palsy (HP:0100021)1.99251759
119Bronchiectasis (HP:0002110)1.98435866
120Neuroendocrine neoplasm (HP:0100634)1.98355873
121Aortic dissection (HP:0002647)1.98138159
122Multiple enchondromatosis (HP:0005701)1.98103276
123Cystic liver disease (HP:0006706)1.97762486
124Hyperthyroidism (HP:0000836)1.97493123
125Colitis (HP:0002583)1.96976558
126Myopathic facies (HP:0002058)1.96647869
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.96505307
128Distal lower limb muscle weakness (HP:0009053)1.95021034
129Increased serum lactate (HP:0002151)1.94924341
130Gowers sign (HP:0003391)1.94788911
131Pheochromocytoma (HP:0002666)1.94158180
132Weak cry (HP:0001612)1.94056642
133Easy fatigability (HP:0003388)1.93063010
134Neoplasm of the adrenal gland (HP:0100631)1.92757381
135Congenital primary aphakia (HP:0007707)1.89232937
136Hypoplastic heart (HP:0001961)1.89120353
137Lipid accumulation in hepatocytes (HP:0006561)1.88713879
138Cerebral edema (HP:0002181)1.88562794
139Dicarboxylic aciduria (HP:0003215)1.88310568
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88310568
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.87414701
142Diaphragmatic weakness (HP:0009113)1.86466162
143Delayed CNS myelination (HP:0002188)1.86329398
144Infertility (HP:0000789)1.85419192
145Mesangial abnormality (HP:0001966)1.85323841
146Infantile muscular hypotonia (HP:0008947)1.84770696
147Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84590881
148EMG: neuropathic changes (HP:0003445)1.84016720
149Congenital malformation of the right heart (HP:0011723)1.83991791
150Hand muscle atrophy (HP:0009130)1.81910896
151Hypoventilation (HP:0002791)1.80211982
152Increased mean platelet volume (HP:0011877)1.78472648
153Soft skin (HP:0000977)1.78350395
154Coronal craniosynostosis (HP:0004440)1.75121727
155Lymphangioma (HP:0100764)1.74139521
156Nasal polyposis (HP:0100582)1.72888192
157Congenital hepatic fibrosis (HP:0002612)1.70157549
158Nephrogenic diabetes insipidus (HP:0009806)1.68837807
159Hydroureter (HP:0000072)1.68691341
160Renal Fanconi syndrome (HP:0001994)1.67697887
161Wrist flexion contracture (HP:0001239)1.66664741
162Ankle contracture (HP:0006466)1.65629152
163Abnormality of the pulmonary veins (HP:0011718)1.64286509
164Focal motor seizures (HP:0011153)1.64047349
165Aplasia/Hypoplasia of the spleen (HP:0010451)1.63766168
166Hyperlipoproteinemia (HP:0010980)1.61054356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.01439317
2TTN3.74832883
3TRIB33.49653290
4PDK33.15972376
5PDK43.15972376
6OBSCN3.09864557
7MYLK3.08303331
8PKN22.95241938
9LMTK22.62118203
10PHKG12.51824726
11PHKG22.51824726
12MUSK2.39681231
13LIMK12.35083225
14EPHB22.33398115
15VRK22.16799976
16MAP4K12.07622203
17NEK12.03136964
18PDK21.97604200
19DMPK1.96295372
20STK241.91987813
21TIE11.89912213
22CCNB11.88932315
23MST41.86572609
24GRK51.75508844
25MAP4K21.70919338
26NME21.68704395
27GRK11.64056791
28MAPK151.60567781
29MARK11.59821913
30ABL21.57987661
31TESK21.57819227
32DYRK21.53275811
33ILK1.52455758
34MAPK121.50743331
35PTK2B1.48416348
36EPHA41.47122375
37NTRK21.46101112
38ARAF1.44260743
39MAP2K31.43162377
40BUB11.42889360
41EIF2AK11.39941654
42STK41.36493181
43EPHA31.32740269
44PINK11.32610710
45BCKDK1.29921036
46PLK21.28433768
47ERN11.27941539
48MAP2K71.27822547
49MINK11.26752592
50NME11.26380900
51NEK21.26141949
52STK391.25942079
53ADRBK11.24607801
54INSRR1.23940388
55EEF2K1.23612128
56ZAK1.21876698
57NTRK11.19734787
58CAMK2G1.16689724
59PRKD31.15316516
60DDR21.14397012
61MAP3K111.13291629
62PAK61.09522326
63KDR1.05065486
64MAPK131.04692803
65PAK21.03202448
66NTRK30.99616322
67SYK0.98884848
68DAPK20.97600842
69CAMK2A0.93870826
70TLK10.92251667
71BRSK10.91239291
72LRRK20.89879340
73BRAF0.89472771
74GRK60.89362467
75RIPK40.89197296
76PIM20.88421472
77DAPK30.88036150
78NUAK10.86653961
79TAOK10.86274538
80PKN10.85298221
81ADRBK20.85147537
82MAPK110.83816589
83PRKD10.80576037
84CAMK2B0.80518844
85MAPKAPK30.80404374
86TGFBR20.77827205
87RPS6KA40.76267886
88MAP3K50.75772515
89DAPK10.75428474
90BMPR1B0.74041525
91CDC42BPA0.73290415
92PRKCE0.73017145
93PTK20.68920884
94CAMK10.67650305
95CSNK1G20.66703777
96ROCK20.66475036
97CSNK1G30.66461463
98BLK0.66399756
99KIT0.66060680
100FER0.64199118
101DYRK30.64114727
102PRKCG0.62812146
103CDK50.61261725
104MAP3K120.59861932
105RPS6KC10.59300070
106RPS6KL10.59300070
107BCR0.58353808
108CSF1R0.57699324
109BMX0.56900314
110MARK30.55695370
111RPS6KA60.55378691
112PRKG20.54879593
113PRKACA0.54844441
114CDK40.54278548
115FES0.53959384
116PRKD20.53701222
117PIK3CA0.52713835
118WNK40.52558866
119CDK80.50567257
120PDK10.50526608
121CSNK1G10.50355853
122MOS0.49611250
123ROCK10.48460141
124CDK140.48142020
125VRK10.47699241
126DYRK1B0.47664222
127CAMK40.46672711
128MARK20.46268145
129RAF10.46159916
130TESK10.44814609
131CDK190.44758481
132SCYL20.44288786
133PRKAA10.44070025
134AKT20.43979578
135TBK10.43411539
136MAP3K70.43407077
137STK110.42537418
138CDC70.42459247
139CAMK2D0.42346425
140MAPKAPK50.42320430
141PRKG10.40680662
142CAMKK10.40091810
143PRKCA0.40051740
144RIPK10.39828012
145WEE10.39222839
146MAP2K60.38972257
147PRKCD0.38608103
148STK38L0.38346227
149WNK30.38135130
150MAP3K30.37300102
151PRKACG0.36306722
152PDPK10.35401654
153GRK70.34816202
154AURKB0.34291200
155STK160.33830870
156BTK0.31555626
157MAP2K10.30234257
158PAK10.28774846
159MAPKAPK20.27577160
160PAK30.25511604
161EIF2AK30.24980785
162MAP3K80.24957547
163CAMKK20.24075854
164MAPK40.23674554

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.04228098
2Cardiac muscle contraction_Homo sapiens_hsa042604.33224653
3Parkinsons disease_Homo sapiens_hsa050123.90557114
4Oxidative phosphorylation_Homo sapiens_hsa001903.62582126
5Dilated cardiomyopathy_Homo sapiens_hsa054142.94249678
6Huntingtons disease_Homo sapiens_hsa050162.86320316
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.86128986
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70304334
9Alzheimers disease_Homo sapiens_hsa050102.69744942
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36943090
11Ribosome_Homo sapiens_hsa030102.14920380
12DNA replication_Homo sapiens_hsa030302.13936430
13Sulfur relay system_Homo sapiens_hsa041221.98928569
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90106650
15Fatty acid elongation_Homo sapiens_hsa000621.86910187
16ECM-receptor interaction_Homo sapiens_hsa045121.86324716
17Carbon metabolism_Homo sapiens_hsa012001.83060631
18Proteasome_Homo sapiens_hsa030501.79104247
19Base excision repair_Homo sapiens_hsa034101.75621607
20B cell receptor signaling pathway_Homo sapiens_hsa046621.72427503
21Tyrosine metabolism_Homo sapiens_hsa003501.71832535
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64457512
23Glutathione metabolism_Homo sapiens_hsa004801.57846043
24Propanoate metabolism_Homo sapiens_hsa006401.52634608
25Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.48867685
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44370360
27Mismatch repair_Homo sapiens_hsa034301.43768618
28Viral myocarditis_Homo sapiens_hsa054161.40428005
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40270479
30Peroxisome_Homo sapiens_hsa041461.38010760
31Pyruvate metabolism_Homo sapiens_hsa006201.34873373
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33581626
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28394103
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27422267
35Chemical carcinogenesis_Homo sapiens_hsa052041.26183883
36Synaptic vesicle cycle_Homo sapiens_hsa047211.25792998
37Primary immunodeficiency_Homo sapiens_hsa053401.24292764
38GABAergic synapse_Homo sapiens_hsa047271.22606066
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22452487
40Phototransduction_Homo sapiens_hsa047441.20739046
41Arginine and proline metabolism_Homo sapiens_hsa003301.20626432
42Sulfur metabolism_Homo sapiens_hsa009201.18342400
43Olfactory transduction_Homo sapiens_hsa047401.18173889
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16888804
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13903626
46Phenylalanine metabolism_Homo sapiens_hsa003601.13045655
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07434210
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.07214646
49Morphine addiction_Homo sapiens_hsa050321.07108420
50Butanoate metabolism_Homo sapiens_hsa006501.01091048
51HIF-1 signaling pathway_Homo sapiens_hsa040661.00273105
52Salivary secretion_Homo sapiens_hsa049700.98636212
53Collecting duct acid secretion_Homo sapiens_hsa049660.98435521
54beta-Alanine metabolism_Homo sapiens_hsa004100.98237319
55Pyrimidine metabolism_Homo sapiens_hsa002400.96929003
56Cocaine addiction_Homo sapiens_hsa050300.95139915
57Glucagon signaling pathway_Homo sapiens_hsa049220.95058824
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94904127
59Purine metabolism_Homo sapiens_hsa002300.92518142
60Hedgehog signaling pathway_Homo sapiens_hsa043400.92080268
61Serotonergic synapse_Homo sapiens_hsa047260.90720427
62Fatty acid degradation_Homo sapiens_hsa000710.90128367
63Homologous recombination_Homo sapiens_hsa034400.90068891
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88102975
65RNA polymerase_Homo sapiens_hsa030200.85842182
66Arachidonic acid metabolism_Homo sapiens_hsa005900.83919140
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83765390
68Calcium signaling pathway_Homo sapiens_hsa040200.83705791
69Dopaminergic synapse_Homo sapiens_hsa047280.80369517
70Oxytocin signaling pathway_Homo sapiens_hsa049210.79988585
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79884953
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78077573
73Protein digestion and absorption_Homo sapiens_hsa049740.77213982
74Glutamatergic synapse_Homo sapiens_hsa047240.77043791
75Cell cycle_Homo sapiens_hsa041100.76735946
76Nucleotide excision repair_Homo sapiens_hsa034200.76713794
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.75266788
78Fatty acid metabolism_Homo sapiens_hsa012120.74484198
79Biosynthesis of amino acids_Homo sapiens_hsa012300.74482344
80Insulin signaling pathway_Homo sapiens_hsa049100.72214401
81Regulation of autophagy_Homo sapiens_hsa041400.72013346
82Pentose phosphate pathway_Homo sapiens_hsa000300.71852745
83Vibrio cholerae infection_Homo sapiens_hsa051100.71101759
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70512234
85Spliceosome_Homo sapiens_hsa030400.69743041
86PPAR signaling pathway_Homo sapiens_hsa033200.69147989
87Nicotine addiction_Homo sapiens_hsa050330.66867011
88Oocyte meiosis_Homo sapiens_hsa041140.66387374
89Axon guidance_Homo sapiens_hsa043600.66318803
90Basal cell carcinoma_Homo sapiens_hsa052170.64687489
91Protein export_Homo sapiens_hsa030600.62669233
92Complement and coagulation cascades_Homo sapiens_hsa046100.62510996
93Pancreatic secretion_Homo sapiens_hsa049720.61025230
94Metabolic pathways_Homo sapiens_hsa011000.60583540
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.60459164
96Retinol metabolism_Homo sapiens_hsa008300.60062941
97Melanogenesis_Homo sapiens_hsa049160.59455971
98Fructose and mannose metabolism_Homo sapiens_hsa000510.59002149
99VEGF signaling pathway_Homo sapiens_hsa043700.58344041
100Folate biosynthesis_Homo sapiens_hsa007900.57249625
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56618924
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56237569
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56126739
104Nitrogen metabolism_Homo sapiens_hsa009100.55797983
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53826492
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53285956
107Insulin resistance_Homo sapiens_hsa049310.52561219
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52108476
109Tryptophan metabolism_Homo sapiens_hsa003800.52001996
110Circadian entrainment_Homo sapiens_hsa047130.50663866
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50565388
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50270640
113RNA transport_Homo sapiens_hsa030130.50238249
114RNA degradation_Homo sapiens_hsa030180.48923029
115Ovarian steroidogenesis_Homo sapiens_hsa049130.48795605
116Epstein-Barr virus infection_Homo sapiens_hsa051690.48100570
117Insulin secretion_Homo sapiens_hsa049110.45568864
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45056548
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.44445259
120Non-small cell lung cancer_Homo sapiens_hsa052230.43800018
121Osteoclast differentiation_Homo sapiens_hsa043800.43074470
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43012241
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.42138736
124Renin secretion_Homo sapiens_hsa049240.39816599
125Long-term potentiation_Homo sapiens_hsa047200.37619415
126Gastric acid secretion_Homo sapiens_hsa049710.37385904
127Galactose metabolism_Homo sapiens_hsa000520.36502775
128AMPK signaling pathway_Homo sapiens_hsa041520.36469195
129HTLV-I infection_Homo sapiens_hsa051660.36412739
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35673893
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35460713
132Glioma_Homo sapiens_hsa052140.35372266
133Platelet activation_Homo sapiens_hsa046110.35012056
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34966327
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34741433
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33833094
137GnRH signaling pathway_Homo sapiens_hsa049120.32491030
138Tight junction_Homo sapiens_hsa045300.30768241
139cAMP signaling pathway_Homo sapiens_hsa040240.30433457
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30165255
141Chronic myeloid leukemia_Homo sapiens_hsa052200.29949923
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28665860
143Acute myeloid leukemia_Homo sapiens_hsa052210.28376580
144FoxO signaling pathway_Homo sapiens_hsa040680.27458665
145Focal adhesion_Homo sapiens_hsa045100.27450591
146Gap junction_Homo sapiens_hsa045400.27021792
147Salmonella infection_Homo sapiens_hsa051320.26533688
148mRNA surveillance pathway_Homo sapiens_hsa030150.26268531
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.25904254
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24314744
151Systemic lupus erythematosus_Homo sapiens_hsa053220.23364814
152Apoptosis_Homo sapiens_hsa042100.21519671
153Amphetamine addiction_Homo sapiens_hsa050310.20771767
154Cholinergic synapse_Homo sapiens_hsa047250.19737123
155Neurotrophin signaling pathway_Homo sapiens_hsa047220.19268184
156MAPK signaling pathway_Homo sapiens_hsa040100.18780282
157Fanconi anemia pathway_Homo sapiens_hsa034600.18662518
158Renin-angiotensin system_Homo sapiens_hsa046140.18625998
159Tuberculosis_Homo sapiens_hsa051520.18386979
160Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17903630

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